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Relevant bibliographies by topics / Glioblastoma – therapy / Dissertations / Theses

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Dissertations / Theses on the topic 'Glioblastoma – therapy'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

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1

Setua, Sonali. "Development of targeted nanomedicine for glioblastoma therapy." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708268.

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2

Kegelman, Timothy P. "MDA-9/Syntenin: From Glioblastoma Pathogenesis to Targeted Therapy." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/4676.

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The most common malignant glioma, glioblastoma multiforme (GBM), remains an intractable tumor despite advances in therapy. Its proclivity to infiltrate surrounding brain tissue contributes greatly to its treatment failure and the grim prognosis of patients. Radiation is a staple in modern therapeutic regimens, though cells surviving radiation become more aggressive and invasive. Consequently, it is imperative to define further the cellular mechanisms that control GBM invasion and identify promising novel therapeutic targets. Melanoma differentiation associated gene-9 (MDA-9/Syntenin) is a high

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3

Gao, Yi. "Development of a novel hTERTC27 based cancer : gene therapy /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557790.

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4

Frixa, Christophe. "Boronated tetraphenylporphyrins for use in boron neutron capture therapy of cancer." Thesis, University of Bath, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268747.

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5

Heywood, Richard Martyn. "NG2/CSPG4 promotes progression of glioblastoma multiforme by enhancing proliferation and resistance to therapy." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.707912.

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6

Gao, Yi, and 高毅. "Development of a novel hTERTC27 based cancer: gene therapy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557790.

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7

Pikhartova-Martinkova, Eva. "Combination of ellipticine chemotherapy and alpha5beta1 integrin-targeted therapy in human glioblastoma." Strasbourg, 2010. https://publication-theses.unistra.fr/restreint/theses_doctorat/2010/PIKHARTOVA-MARTINKOVA_Eva_2010.pdf.

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Les glioblastomes sont des tumeurs cérébrales agressives pour lesquelles les thérapies classiques se révèlent souvent inefficaces. Les intégrines peuvent aussi réguler l’angiogénèse, l’embryogenèse, la prolifération, la différentiation, la migration et la survie. Nous avons proposé l`intégrine α5β1 comme un cible thérapeutique pour les glioblastomes, comme elle est surexprimée dans les gliomes en fonction du grade tumoral et comme les travaux récents l`indiquent ayant un rôle central dans un réseau fonctionnel de la cellule tumoral. Les deux lignées cellulaires de glioblastome testés (U87MG et

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8

Haseley, Amy M. "The Effect of the Tumor Microenvironment on Oncolytic Virus Therapy for Glioblastoma." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1350413344.

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9

Skog, Johan. "The quest for new improved adenovirus gene therapy vectors against glioma tumours." Doctoral thesis, Umeå : Umeå University, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-624.

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10

Agliardi, Giulia. "Development of a Chimeric Antigen Receptor (CAR)-based T cell therapy for glioblastoma." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10025011/.

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High grade gliomas are aggressive brain tumours for which treatment is highly challenging due to the location within the central nervous system (CNS), which may reduce access of cytotoxic chemotherapy, and their infiltrative growth, which precludes complete surgical resection. Current treatment includes surgical removal – wherever possible - followed by radiotherapy and chemotherapy. However, recurrence is common, resulting in a survival of only 12 to 15 months after diagnosis. This highlights the need for new therapies. Chimeric antigen receptors (CARs) are synthetic molecules which combine t

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11

Angara, Kartik Prasad. "CXCR2 Expressing Tumor Cells Drive Vascular Mimicry in Anti-angiogenic Therapy Resistant Glioblastoma." Thesis, Augusta University, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10839522.

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<p> Glioblastoma (GBM) is a hypervascular and hypoxic neoplasia of the central nervous system with an extremely high rate of mortality. Owing to its hypervascularity, anti-angiogenic therapies (AAT) have been used as an adjuvant to the traditional surgical resection, chemotherapy, and radiation to normalize blood vessels, control abnormal vasculatures and prevent recurrence. The benefits of AAT have been transient and the tumors were shown to relapse faster and demonstrated particularly high rates of AAT-induced therapy resistance due to activation of alternative neovascularization mechanisms.

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12

Thomas, Sean Casey. "A Developed and Characterized Orthotopic Rat Glioblastoma Multiforme Model." Thesis, Virginia Tech, 2020. http://hdl.handle.net/10919/100772.

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This thesis project serves to fill experimental gaps needed to advance the goal of performing pre-clinical trials using an orthotopic rat glioblastoma model to evaluate the efficacy of high-frequency electroporation (H-FIRE) and QUAD-CTX tumor receptor-targeted cytotoxic conjugate therapies, individually and in combination, in selectively and thoroughly treating glioblastoma multiforme. In order to achieve this, an appropriate model must be developed and characterized. I have transduced F98 rat glioma cells to express red-shifted firefly luciferase, which will facilitate longitudinal tumor mon

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13

Wu, W., J. L. Klockow, S. Mohanty, et al. "Theranostic nanoparticles enhance the response of glioblastomas to radiation." ivyspring, 2019. http://hdl.handle.net/10454/17326.

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Yes<br>Despite considerable progress with our understanding of glioblastoma multiforme (GBM) and the precise delivery of radiotherapy, the prognosis for GBM patients is still unfavorable with tumor recurrence due to radioresistance being a major concern. We recently developed a cross-linked iron oxide nanoparticle conjugated to azademethylcolchicine (CLIO-ICT) to target and eradicate a subpopulation of quiescent cells, glioblastoma initiating cells (GICs), which could be a reason for radioresistance and tumor relapse. The purpose of our study was to investigate if CLIO-ICT has an additive

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14

Cartiaux, Benjamin. "Etude de l'effet radio-sensibilisant de nanotubes de carbone dans le modèle de glioblastome canin spontané, en vue d'un développement chez l'Homme." Thesis, Toulouse 3, 2020. http://www.theses.fr/2020TOU30133.

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Les gliomes représentent les tumeurs primaires les plus fréquentes du système nerveux central avec le pronostic le plus mauvais, malgré une prise en charge précoce associée à un traitement agressif et multimodal. De nouvelles thérapies sont donc à l'étude afin d'améliorer la médiane de survie des patients. Parmi ces pistes de recherche, l'optimisation de la radiothérapie (RT) du glioblastome (GBM) est un enjeu majeur. Dans ce contexte, l'utilisation de nanotubes de carbone (NTC) est prometteuse : en plus d'être potentiellement radio-sensibilisants, les NTC contenant du gadolinium (Gd) peuvent

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15

Mooney, Marie R. "Precision Medicine Approaches to Integrating Genomics with Cancer Therapy| Applications in Glioblastoma and Lymphoma." Thesis, Van Andel Research Institute, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10275288.

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<p> The word "cancer" rarely stands alone, usually prefaced with its anatomical location: lung cancer, prostate cancer, brain cancer. With the advancement of high-throughput omics approaches, specific oncogenic events are reorganizing the landscape of cancer classification, at once creating commonalities between cancers arising in diverse anatomical locations and dividing organ-centric classifications of cancer into a multitude of subtypes. The term "precision medicine" postulates that these new, data-driven groupings based on molecular characterization are the key to making rational therapeut

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16

Eagles, Lawrence. "Metformin as a potential therapy for malignant astrocytoma." Thesis, University of Wolverhampton, 2018. http://hdl.handle.net/2436/621724.

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Background Glioblastoma Multiforme (GBM) is the most commonly occurring tumour of the central nervous system (CNS). Currently GBM is considered an incurable malignancy with patients experiencing abysmal life expectancies. Lack of progress in the discovery of novel treatments has led to the repurposing of existing licenced medication as a possible alternative option. Metformin is from the biguanide family of drugs and is the most common medication used in the treatment of type 2 diabetes. Clinical studies have reported that, in type 2 diabetic patients, metformin might reduce cancer incidence a

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17

Adamski, Vivian [Verfasser]. "Analysis of chemotherapeutic-induced tumor dormancy in Glioblastoma Multiforme and alternative therapy approaches / Vivian Adamski." Kiel : Universitätsbibliothek Kiel, 2019. http://d-nb.info/1197612467/34.

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18

Rogers, William. "Profiling and targeting HOX-PBX dimers in adult and paediatric glioblastoma as a novel therapy." Thesis, University of Surrey, 2018. http://epubs.surrey.ac.uk/849922/.

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HOX genes encode a family of transcription factors that play an essential role in embryonic patterning during foetal development. These genes are reported to be aberrantly expressed in numerous cancers, including glioblastoma (GBM). Previous research indicates that HOX genes are overexpressed in GBM tumours compared to normal human astrocytes (NHA). Three Amino Acid Loop Extension Homeobox (TALE) proteins act as important co-factors for HOX proteins, modulating their binding affinities to genomic targets. TALE members Pre-B-cell leukaemia homeobox (PBX) 1-4, bind anterior HOX proteins, facilit

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19

Silva, Emanoel Pedro de Oliveira. "Estudos fotofísicos e fotobiológicos de sistemas de liberação contendo o fármaco fotossensível cloro-ftalocianina de alumínio para aplicação em terapia fotodinâmica." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/60/60137/tde-21102016-112503/.

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A terapia fotodinâmica (TFD) tem se apresentado nos últimos anos como uma alternativa para o tratamento de tumores cutâneos, viscerais e sistêmicos, demonstrando resultados promissores, tanto em estudos in vitro como in vivo. Trata-se de uma técnica simples e não invasiva. A terapia consiste na excitação de um fármaco fotossensibilizante por uma fonte de luz visível que depois de absorvida pela molécula, leva a produção espécies reativas de oxigênio (EROs) em presença do oxigênio molecular por uma sequencia de reações fotoquímicas. Nesse trabalho propõe-se a preparação, caracterização e detrem

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20

Shi, Minghan. "Convection-enhanced delivery of platinum drugs and their liposomal formulations plus radiation therapy in glioblastoma treatment." Thèse, Université de Sherbrooke, 2016. http://hdl.handle.net/11143/8786.

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Abstract : Glioblastoma is the most common and aggressive brain cancer in adults. The current standard-of-care treatment includes surgical resection, radiation therapy with concomitant and adjuvant temozolomide (TMZ) chemotherapy. However, the addition of TMZ to radiation therapy only increased the median survival time (MeST) by 2.5 months. This limited improvement is partially attributable to the low accumulation of chemotherapeutic drugs in the brain tumor due to the blood-brain barrier (BBB). Thus, new delivery methods such as intra-arterial, BBB disruption and convection-enhanced delivery

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21

Arias, Ramos Nuria. "Towards improvement of preclinical glioblastoma management: detection, therapy and assessment of response using magnetic resonance techniques." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/667287.

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El Glioblastoma (GB) es el tumor primario agresivo más común, con mal pronóstico y sin cura actualmente. Aunque se aplique tratamiento agresivo (quimioterapia con Temozolamida, TMZ, y radioterapia) generalmente hay recidiva. Esta tesis se ha centrado en la mejora del diagnóstico, seguimiento de la respuesta a terapia y manejo del GB con técnicas de resonancia magnética (RM) (Imagen por Resonancia Magnética/IRM e Imagen Espectroscópica por Resonancia Magnética/IERM), utilizando el modelo preclínico de GB GL261. Los agentes de contraste (AC) utilizados para diagnóstico de GB están basados en Ga

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22

Langer, Julia. "Metabolic profiling of ASS1 negative and ASS1 positive glioblastoma subtypes to identify novel targets for therapy." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/47973.

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Glioblastoma multiforme (GBM) are the most common and most malignant brain tumours. Despite treatment advances, average survival remains unacceptably low with 15-months, hence novel therapies are desperately needed. Cellular metabolism plays a central role in cancers. Sensitivity towards arginine-deprivation via pegylated arginine deaminase (ADI-PEG20) therapy has been identified in GBM, arresting proliferation in methylated arginino-succinate-synthetase-1 (ASS1M) and not unmethylated ASS1 (ASS1U) GBM cells. Advances of biochemical techniques and analysis have facilitated therapeutic target id

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23

Kühnle, Matthias. "Experimental therapy and detection of glioblastoma : investigation of nanoparticles, ABCG2 modulators and optical imaging of intracerebral xenografts." kostenfrei, 2010. http://epub.uni-regensburg.de/13008/.

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24

Volmar, Marie Nhery Murielle [Verfasser], and Rainer [Akademischer Betreuer] Glaß. "Cannabidiol for glioblastoma therapy : models, molecular pathways, and predictive markers / Marie Nhery Murielle Volmar ; Betreuer: Rainer Glaß." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1214593313/34.

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25

Meisen, Walter Hans. "Improving Oncolytic Viral Therapy for Primary and Metastatic Tumors in the Brain." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429187113.

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26

Hasslacher, Sebastian [Verfasser]. "In vitro effect of ionizing radiation on primary glioblastoma cells as a basis for multitarget therapy / Sebastian Hasslacher." Ulm : Universität Ulm, 2020. http://d-nb.info/1205001751/34.

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27

Peters, Tanja [Verfasser]. "Development and in vitro testing of liposomal gadolinium-formulations for neutron capture therapy of glioblastoma multiforme / Tanja Peters." Mainz : Universitätsbibliothek Mainz, 2013. http://d-nb.info/1043939555/34.

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28

Ivey, Jill Winters. "Investigating the Applications of Electroporation Therapy for Targeted Treatment of Glioblastoma Multiforme Based on Malignant Properties of Cells." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/78806.

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Glioblastoma multiforme (GBM) is the most common and lethal primary brain cancer with an average survival time of 15 months. GBM is considered incurable with even the most aggressive multimodal therapies and is characterized by near universal recurrence. Irreversible electroporation (IRE) is a cellular ablation method currently being investigated as a therapy for a variety of cancers. Application of IRE involves insertion of electrodes into tissue to deliver pulsed electric fields (PEFs), which destabilize the cell membrane past the point of recovery, thereby inducing cell death. While this tr

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29

Guhasarkar, Dwijit. "A Walk on the Fine Line Between Reward and Risk: AAV-IFNβ Gene Therapy for Glioblastoma: A Dissertation". eScholarship@UMMS, 2007. http://escholarship.umassmed.edu/gsbs_diss/843.

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Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor. The current standard-of-care treatment including surgery, radiation and temozolomide (TMZ) chemotherapy does not prolong the survival satisfactorily. Here we have tested the feasibility, efficacy and safety of a potential gene therapy approach using AAV as gene delivery vehicle for treatment of GBM. Interferon-beta (IFNβ) is a cytokine molecule also having pleiotropic anticancerous properties. Previously it has been shown by our group that AAV mediated local (intracranial) gene delivery of human IFNβ (hIFNβ) c

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Guhasarkar, Dwijit. "A Walk on the Fine Line Between Reward and Risk: AAV-IFNβ Gene Therapy for Glioblastoma: A Dissertation". eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/843.

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Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor. The current standard-of-care treatment including surgery, radiation and temozolomide (TMZ) chemotherapy does not prolong the survival satisfactorily. Here we have tested the feasibility, efficacy and safety of a potential gene therapy approach using AAV as gene delivery vehicle for treatment of GBM. Interferon-beta (IFNβ) is a cytokine molecule also having pleiotropic anticancerous properties. Previously it has been shown by our group that AAV mediated local (intracranial) gene delivery of human IFNβ (hIFNβ) c

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31

Krasheninnikova, Maria Alieva. "Adipose tissue mesenchymal stromal cells as therapeutic vehicles against glioblastoma." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/97086.

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Lately adipose tissue mesenchymal stem cells (hAMSCs) have emerged as cellular vehicles for therapy of solid tumors, due to their ease of isolation and manipulation, and wound/tumor homing capacity. HAMSCs have been successfully used in suicide gene therapy, employing the prodrug activating system based on Herpes simplex virus type I thymidine kinase (HSV-TK)/ganciclovir (GCV). In the current study we demonstrate an effective model of glioblastoma therapy based on the use of genetically modified hAMSCs and in vivo monitoring of tumor and therapeutic cells. Due to the capacity of photons to pa

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Mucha, Birte [Verfasser], and Ulrich [Akademischer Betreuer] Hahn. "Magnetically induced directed Cell Migration as a new Approach for Therapy of Glioblastoma multiforme / Birte Mucha. Betreuer: Ulrich Hahn." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2012. http://d-nb.info/1020931280/34.

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33

Ferrer, Font Laura. "Tuning response to therapy in preclinical GL261 glioblastoma through CK2 targeting and temozolomide metronomic approaches: non-invasive assessment with MRI and MRSI-based molecular imaging strategies." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/402400.

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El treball descrit en aquesta tesi fa referència al tractaments de glioblastomes (GBM) GL261 preclínics que creixen en ratolins C57BL/6, també al seguiment no invasiu de la resposta a la teràpia, usant tècniques de ressonància magnètica (RM). El model immunocompetent GL261 GBM s’indueix per injecció estereotàctica de cèl·lules GL261 a l’estriat de ratolins WT C57BL/6. Tres agents terapèutics s’han provat en aquest model: el CX-4945®, inhibidor de la proteïna kinasa II (CK2), i dos agents alquilants d’administració oral usats habitualment en pràctica clínica pel tractament de GBM: la temozolami

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Villamañán, de Santiago Lucía. "Unraveling CK2 inhibition and temozolomide contribution to therapy response in preclinical GL261 glioblastoma: immune system implications and magnetic resonance based nosological imaging." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/666881.

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El glioblastoma (GB) es el tumor primario más común en adultos. Debido a su mal prognóstico, es urgente encontrar mejoras en su tratamiento. El objetivo de esta tesis es estudiar el efecto de inhibidores de CK2 y del agente alquilante Temozolamida (TMZ) a la respuesta a terapia en el modelo de GB preclínico GL261 utilizando tanto métodos in vitro (línea celular GL261) como in vivo (ratones GL261 con tumores). La enzima CK2 es un tetrámero compuesto por dos subunidades catalíticas (α/ α') y dos subunidades reguladoras (β). En esta tesis, se describe el contenido diferencial de la subunidad CK2

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Li, Min [Verfasser], and Rainer [Akademischer Betreuer] Glaß. "Studies on the two secretory peptides Apelin and Humanin to target the tumor microenvironment for glioblastoma therapy / Min Li ; Betreuer: Rainer Glaß." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/121195725X/34.

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Paula, Leonardo Barcelos de. "Efeitos da Nanoemulsão de Ftalocianina Cloro-Alumínio na Regulação da Via do Fator de Crescimento Epidermal em Glioblastoma e Meduloblastoma." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-22052015-155141/.

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O glioblastoma multiforme (GBM) pode desenvolver-se rapidamente sem evidências clínicas, radiológicas ou morfológicas de um tumor precursor menos maligno. Entretanto, um novo tumor pode desenvolver-se a partir de células gliais normais ou de suas precursoras, sendo chamado de GBM primário. Já meduloblastoma é um tumor embrionário maligno do cerebelo, cuja incidência ocorre preferencialmente em crianças de até 7 anos. Os tumores de cérebro se diferem entre si em nível molecular. A amplificação do gene EGFR (Receptor do Fator de Crescimento Epidermal) com consequente elevação da expressão do rec

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Mihaliak, Alicia M. "Clinically Relevant Doses of Chemotherapy Drugs Selectively and Reversibly Block Glioblastoma Neurosphere Proliferation in vitro: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/492.

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My thesis research began with a project in which we were trying to determine the function of embryonic stem cell (ESC)-specific miRNAs. Using luciferase constructs containing miRNA binding sites, luciferase expression was inhibited by endogenous miRNAs in ESCs, and by exogenous miRNAs in HeLa cells. Inhibition of luciferase expression by miRNAs was inhibited in HeLa cells using 2’O-methyl-oligonucleotides. In ESCs, 2’O-methyl-oligonucleotides were only effective in partially inhibiting miR290 function. Partial inhibition of miR290 did not result in any obvious phenotypic changes in mESCs. Late

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Toussaint, Magali. "Thérapies par rayonnements appliquées au cas du glioblastome : intérêt du suivi par spectroscopie et imagerie de diffusion par résonance magnétique : vers une thérapie bimodale." Thesis, Université de Lorraine, 2016. http://www.theses.fr/2016LORR0188/document.

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Les limitations rencontrées aujourd'hui dans le traitement du glioblastome (GBM) concernent notamment la qualité de l'exérèse dont dépend le pronostic et le manque de contrôle local de la croissance tumorale, sachant que les récidives apparaissent dans plus de 80% des cas dans le volume cible de radiothérapie. Dans ce contexte, la thérapie photodynamique interstitielle (iPDT) se présente comme un outil complémentaire prometteur qui permettrait d'améliorer le contrôle local de la tumeur. La première partie de ce travail de thèse a porté sur le suivi longitudinal par Imagerie par Résonance Magné

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Schoenfeld, Joshua David. "The role of redox-active iron metabolism in the selective toxicity of pharmacological ascorbate in cancer therapy." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6273.

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Pharmacological ascorbate, intravenous administration of high-dose vitamin C aimed at peak plasma concentrations ~ 20 mM, has recently re-emerged, after a controversial history, as a potential anti-cancer agent in combination with standard-of-care radiation and chemotherapy-based regimens. The anti-cancer effects of ascorbate are hypothesized to involve the auto-oxidation or metal-catalyzed oxidation of ascorbate to generate H2O2, and preclinical in vitro and in vivo studies in a variety of disease sites demonstrate the efficacy of adjuvant ascorbate. Furthermore, phase I clinical trials in pa

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Tavallai, Seyedmehrad. "Lapatinib and Sorafenib Kill GBM Tumor Cells in a Greater than Additive Manner." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3234.

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Glioblastoma multiforme (GBM) is the most common and malignant brain tumor in adults, affecting thousands of people worldwide every year, with a life expectancy, post diagnosis of 12 months. Surgery, radiotherapy and chemotherapy together, result in an overall mean survival not exceeding 15 months. Targeted therapeutic agents sorafenib, an oral multi kinase inhibitor, and lapatinib, an epidermal growth factor receptor (EGFR) inhibitor, used in combination have been shown to kill GBM cells be through inhibition of major growth mediating signaling pathways that are frequently over expressed in g

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Tabouret, Emeline. "Glioblastome et angiogenèse : profils évolutifs, interaction avec l'invasivité et implications thérapeutiques." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM5012/document.

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Les glioblastomes sont les tumeurs primitives cérébrales les plus agressives de l’adulte. Elles sont caractérisées par une importante néo-angiogenèse, conduisant au développement des anti-VEGF chez ces patients. L’objectif de cette thèse était d’identifier de potentiels marqueurs prédictifs de l’activité du bevacizumab et d’analyser le profil évolutif des facteurs de l’angiogenèse. En situation de récidive d’un gliome de haut grade, si aucun facteur clinique ne semble permettre d’identifier un sous-groupe de patients bénéficiant particulièrement du bevacizumab, les taux plasmatiques avant trai

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Ngwabyt, Bikeye Sandra-Nadia. "Etude par ARN interférence de l’expression du gène ASPM dans les cellules souches tumorales des gliomes de haut grade." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA11T030/document.

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Les gliomes sont les tumeurs cérébrales primitives les plus fréquentes de l’adulte. Le glioblastome (grade IV) en est la forme la plus agressive, caractérisé par sa résistance aux traitements actuels (chirurgie, chimiothérapie et radiothérapie). La mortalité de cette pathologie est quasi constante (survie médiane de 15 mois), ce qui justifie l’importance de découvrir de nouvelles cibles thérapeutiques. Le challenge est d'arriver à identifier des marqueurs spécifiques pour proposer un schéma thérapeutique alignant des stratégies de thérapies ciblées qui vont améliorer la prise en charge cliniqu

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Pietschmann, Sophie. "Charakteristika, Therapie und Prognose von Patienten mit metastasierten WHO Grad IV Gliomen - Eine Metaanalyse individueller Patientendaten." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-216728.

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Da hochgradige Gliome nur eine geringe Tendenz zur Metastasierung aufweisen, beschränkte sich das klinische Wissen über diesen seltenen Krankheitsverlauf bisher im Wesentlichen auf die Erkenntnisse aus Einzelfallberichten und kleineren Fallserien. Eine detaillierte Analyse der beschriebenen Fälle war bisher nicht verfügbar. Die vorliegende Arbeit stellt eine systematische Auswertung der wissenschaftlichen Literatur über Patienten mit metastasierten Glioblastomen oder Gliosarkomen dar. Unser Ziel war es, sämtliche Publikationen zu berücksichtigen, welche bis April 2013 veröffentlicht worden si

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Davanzo, Nathalia Nossi. "Desenvolvimento de nanopartículas proteicas polimerizadas para veiculação de fotoativos aplicáveis ao tratamento de câncer do sistema nervoso central." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/59/59138/tde-23012017-163848/.

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Glioblastoma multiforme (GBM) é o tipo mais comum e agressivo de tumor cerebral em adultos. O tempo de vida do paciente diagnosticado com GBM é, em média, 14 meses, apesar dos tratamentos convencionais, como a radioterapia, neurocirurgia e quimioterapia. A terapia fotodinâmica (TFD), juntamente com a nanotecnologia, são tratamentos alternativos e promissores para o combate do câncer do sistema nervoso central. Sendo assim, foi desenvolvido e avaliado nanopartículas de soro albumina humano (PAM), para veiculação controlada de fotoativos (AlClPc e curcumina) aplicáveis no tratamento fotodinâmico

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Hardcastle, Jayson James. "Vstat120 modulates inhibits oncolytic viral therapy induced angiogenesis and innate pro-inflamatory response, augmenting oncolytic viral thereapy of glioblastom multiforme." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1305920551.

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Kratzsch, Tobias [Verfasser]. "Die zielgerichtete Therapie des Glioblastoma multiforme : Präklinische experimentelle Studien zur Wirksamkeit neuer Tyrosinkinase-Inhibitoren sowie epigenetisch wirksamer Substanzen an unterschiedlichen Glioblastom-Mausmodellen / Tobias Kratzsch." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://d-nb.info/1079524525/34.

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Clark, Aaron J. "The Expression and Function of Wilms' Tumor 1 in Malignant Glioma." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/1665.

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Beyer, Stefanie. "Charakteristika, Therapie und Outcome von Patienten mit spinalem Glioblastom oder Gliosarkom - Ein systematischer Review." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-209213.

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Gliome stellen mit 30-40 % die häufigsten intrakraniellen Tumoren dar. Darunter ist das Glioblastom, auch als Glioblastoma multiforme bezeichnet, mit ca. 50 % am stärksten vertreten und macht somit allein etwa 20 % aller Hirntumoren aus (Russell und Rubinstein 1989). Neben einer Metastasierung über den Liquor können diese Tumoren auch sehr selten als primäre Neubildung im Rückenmark vorkommen. Ebenso ist dort die Entwicklung eines sekundären Glioblastoms aus dem fortschreitenden Wachstum eines niedriggradigen Astrozytoms heraus möglich (Sure et al. 1997). Aufgrund ihres diffus infiltrativen Wa

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Linz, Ute. "Ein neues Therapieschema für Glioblastoma multiforme Ergebnis einer Analyse heutiger Behandlungskonzepte sowie der Biologie und Genetik des Tumors /." Jülich : Forschungszentrum Jülich, Zentralbibliothek, 2003. http://deposit.d-nb.de/cgi-bin/dokserv?idn=969263147.

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Brünner, Jeanette [Verfasser]. "Antiangiogene Therapie in Kombination mit Temozolomid beim experimentellen MGMT-methylierten Glioblastom / Jeanette Brünner." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1042940363/34.

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