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Dissertations / Theses on the topic 'Gliomas'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Lilja, Åsa. "Psychoneurooncology psychological dynamics in glioma patients /." Lund : Dept. of Psychology, Lund University, 1992. http://books.google.com/books?id=SnZrAAAAMAAJ.

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2

Sadeghi-Meibodi, Niloufar. "Image-based biomarkers for the invivo evaluation of human brain gliomas." Doctoral thesis, Universite Libre de Bruxelles, 2010. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209991.

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Gliomas constitute 36% of all primary brain tumors and 81% of all primary malignant brain tumors. The overall prognosis in patients with gliomas depends mainly on the location and histologic grade of the tumor.<p>The World Health Organization classification of gliomas is the primary basis for guiding therapy and assessing overall prognosis in gliomas. This classification system, based on histological features, often falls short of predicting therapeutic response of individual tumors within the same histological grade. Yet, it still remains the grading method for both research and clinical pros
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3

Nanda, Dharminderkoemar. "Gene therapy for gliomas." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/13140.

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4

Noreen, Razia. "FTIR imaging of collagens in gliomas." Thesis, Bordeaux 1, 2011. http://www.theses.fr/2011BOR14316/document.

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Le gliome est le type le plus agressif et mortel de tumeur cérébrale. Ces tumeurs se caractérisent par la présence conjointe de phénotypes solides (de bas grade, moins invasif, hautement vascularisé) et diffus (haut grade, très envahissant et diffus) des glioblastomes multiformes. Les collagènes sont des composants majeurs de la MEC des cellules tumorales des gliomes, et sont également présents dans la membrane basale des vaisseaux sanguins, mais avec une composition différente entre vasculatures saine et tumorale. L'abondance et la typologie des collagènes dans la MEC des cellules tumorales e
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5

Alentorn, Agusti. "Caractérisation génomique et génétique des gliomes diffus de bas grade de l’adulte." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T011.

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La caractérisation moléculaire multidimensionnelle des tumeurs et des tumeurs gliales en particulier est une étape importante pour l’identification de biomarqueurs (diagnostique, pronostique, théranostique et/ou de prédisposition), pour l’identification de cibles thérapeutiques et pour une meilleure compréhension de l’oncogénèse moléculaire.Nos travaux ont permis de confirmer et de consolider certaines données de la littérature comme par exemple : (i) la valeur pronostique favorable de la codélétion 1p/19q, (ii) la valeur pronostique favorable de la mutation IDH, (iii) le caractère mutuellemen
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6

Fu, Peng. "Membrane Hsp70 expression in gliomas." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-149571.

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7

Horst, Maarten ter. "Gene therapy of malignant gliomas." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/10864.

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8

Lau, Cara Jean. "Gene therapy for malignant gliomas." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18478.

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Gliomas are the most common primary brain tumours found in adults. The median survival of patients diagnosed with the most malignant form, glioblastoma multiforme (GBM), is 9-12 months and has changed little over the years despite advances in medical technology. Gene therapy may offer new solutions to treat this resistant disease. Hence, we tested three different gene therapy strategies. In our first study, we tested the efficacy of targeted therapy to correct common aberrations found in gliomas including amplification/mutation of receptor tyrosine kinases (RTK) and loss of PTEN, which result
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9

Bergthold, Guillaume. "Genomic Profiling of Pediatric Low-Grade Gliomas." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA11T053/document.

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Les gliomes de bas-grade représentent la tumeur cérébrale la plus fréquente chez l’enfant. Elles sont caractérisées par un large spectre de sous-types tumoraux, très hétérogènes. Leur définition actuelle est principalement basée sur des critères histologiques ce qui représente une limite importante car ces classifications souffrent d’un manque de précision. Les progrès récents de la génomique nous permettent d’approfondir considérablement les connaissances sur la biologie de ces tumeurs afin d’enrichir leur classification actuelle. Ce travail présente une analyse approfondie des altérations gé
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10

Gulati, Sasha. "Surgical Resection of High-Grade Gliomas." Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for laboratoriemedisin, barne- og kvinnesykdommer, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-16444.

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Reseksjon av høygradige gliomer Høygradige gliomer er den vanligste formen for primær hjernesvulst. Glioblastomer (Verdens Helseorganisasjon grad IV) og anaplastiske astrocytomer (Verdens Helseorganisasjon grad III) utgjør mellom 70 og 85 % av høygradige gliomer. Høygradige gliomer er assosiert med både høy morbiditet og mortalitet. Nærmest alle pasienter med høygradige gliomer opplever tilbakefall og dør som følge av sykdommen. Til tross for kirurgi, strålebehandling og cellegift, er median overlevelse for pasienter med glioblastom fremdeles under 12 måneder. For pasienter med anaplastisk ast
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11

陳淑儀 and Shuk-yee Annie Chan. "Expression of angiogenic regulators in gliomas." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31222274.

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The Best M.Phil Thesis in the Faculties of Dentistry, Engineering, Medicine and Science (University of Hong Kong), Li Ka Shing Prize,1997-1999<br>published_or_final_version<br>Pathology<br>Master<br>Master of Philosophy
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12

Patel, Hemant. "Boron-10 uptake in experimental gliomas." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266375.

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13

Yu, Jennifer. "Bioinformatics Analysis of Vasorin in Gliomas." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1484927314447688.

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14

Chan, Shuk-yee Annie. "Expression of angiogenic regulators in gliomas /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21451497.

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15

Alvarez, Robinson Franco. "Dinâmica de gliomas e possíveis tratamentos." reponame:Repositório Institucional da UFABC, 2016.

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Orientador: Prof. Dr. Roberto Venegeroles Nascimento<br>Dissertação (mestrado) - Universidade Federal do ABC, Programa de Pós-Graduação em Física, 2016.<br>Neste trabalho se estudaram aspectos básicos relacionados com a dinâmica de células cancerígenas do tipo B-Linfoma BCL1 e de gliomas fazendo ênfases neste último caso. O trabalho se iniciou revisando alguns modelos populacionais do câncer inspirados nos trabalhos de Lotka e Volterra o qual oferecem uma descrição muito simples da interação entre o câncer (presa) e o sistema imunológico (caçador). Posteriormente é revisado um modelo global es
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16

Carminati, Patricia de Oliveira. "Respostas celulares aos danos causados pelo antitumoral cisplatina em linhagens de fibroblastos humanos normais (MRC-5) e astrocítica (U343 MG-a)." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-21082007-103139/.

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Uma variedade de agentes antitumorais é capaz de induzir danos no material genético e estimular respostas como o bloqueio do ciclo celular, reparo do DNA ou apoptose. A resposta inicial das células é o bloqueio no ciclo em uma tentativa de reparar o dano, no entanto, se esse dano for muito extenso ou comprometer o metabolismo celular, uma cascata de sinalização aciona mecanismos alternativos que inibem a proliferação das células e acionam vias de morte. Os astrocitomas malignos são os tumores cerebrais mais comuns que afetam o sistema nervoso central, compreendendo mais de 60% dos tumores cere
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17

Zielger, David Women's &amp Children's Health Faculty of Medicine UNSW. "Targeting anti-apoptotic mechanisms in malignant gliomas." Awarded by:University of New South Wales. Women's & Children's Health, 2009. http://handle.unsw.edu.au/1959.4/43713.

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Novel strategies for the treatment of malignant gliomas are urgently needed. They are characterised by an inherent resistance to both chemo- and radiotherapeutics resulting in unrelenting tumour progression. While the exact mechanisms of treatment resistance remain undefined, it is now recognized that multiple components within the apoptotic pathway are heavily dysregulated in glioma cells and that the over-expression of anti-apoptotic proteins in patient samples correlates with inferior patient survival. The Inhibitor of Apoptosis Proteins (lAPs) represent the final molecular blockade prevent
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18

Zlatescu, Magdalena C. "Molecular determinants of chemotherapeutic response in gliomas." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq30854.pdf.

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19

Mulholland, Paul James. "Genetic aberrations in high-grade astrocytic gliomas." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430754.

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20

Abel, Peter. "Characterisation of cytokine secretion in malignant gliomas." Thesis, University of Central Lancashire, 2017. http://clok.uclan.ac.uk/23092/.

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Cytokines are proteins produced by cells of the immune system. The working hypothesis of the thesis is to show that the lymphocytes and glial cells in Glioblastoma Multiformae patients have an altered pattern of secretion of cytokines compared with low-grade and non-cancerous patients. Lymphocyte subset analysis was performed using flow cytometry. Serum specimens taken from both high and low grade glioma patients were analysed with samples taken from control patients with no history of cancer. Cerebro-spinal fluid was analysed from high-grade glioma patients. Comparisons of high grade pre-surg
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21

Fedrigo, Carlos Alexandre. "Inibição da via PI3K-Akt em gliomas." Pontifícia Universidade Católica do Rio Grande do Sul, 2012. http://hdl.handle.net/10923/4518.

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Made available in DSpace on 2013-08-07T19:05:17Z (GMT). No. of bitstreams: 1 000439149-Texto+Completo-0.pdf: 1490829 bytes, checksum: bd616615ee5265db0a960d6f77c8581d (MD5) Previous issue date: 2012<br>Glioblastoma multiforme (GMB) is the most malignant and common type of all astrocytic tumours. Current standard treatment for GBM patients involves maximum surgical resection of the tumour, followed by radiotherapy and chemotherapy, usually containing the alkylating agent Temozolomide (TMZ). Despite this aggressive combination therapy, the survival rate of GBM patients is still low. This work
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22

Janczar, Karolina. "The mitochondrial translocator protein in human gliomas." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5877.

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The translocator protein (TSPO) is an 18 kDa molecule spanning the outer mitochondrial membrane. Structural predictions, reported physical interactions and experimental data from diverse models suggest that TSPO is involved in apoptosis, proliferation and steroidogenesis. TSPO is up-regulated in several human cancers and its high levels are frequently associated with advanced disease and poor outcome. TSPO was shown to be up-regulated in astrocytomas and this was correlated with high tumour grade and shorter patient survival. Here it is confirmed that TSPO is highly expressed in astrocytomas a
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23

Visani, Michela <1984&gt. "MicroRNAs expression analysis in high grade gliomas." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5525/1/Visani_Michela_tesi.pdf.

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Several biomarkers had been proposed as useful parameters to better define the prognosis or to delineate new target therapy strategies for glioblastoma (GBM) patients. MicroRNAs could represent interesting molecules, for their role in tumorigenesis and cancer progression and for their specific tissue expression. Although many studies have tried to identify a specific microRNAs signature for glioblastoma, by now an exhaustive GBM microRNAs profile is far to be well defined. In this work we set up a real-time qPCR, based on LNA primers, to investigate the expression of 19 microRNAs in brain tum
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Visani, Michela <1984&gt. "MicroRNAs expression analysis in high grade gliomas." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5525/.

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Several biomarkers had been proposed as useful parameters to better define the prognosis or to delineate new target therapy strategies for glioblastoma (GBM) patients. MicroRNAs could represent interesting molecules, for their role in tumorigenesis and cancer progression and for their specific tissue expression. Although many studies have tried to identify a specific microRNAs signature for glioblastoma, by now an exhaustive GBM microRNAs profile is far to be well defined. In this work we set up a real-time qPCR, based on LNA primers, to investigate the expression of 19 microRNAs in brain tum
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Bruyère, Céline. "Caractérisation du rôle des chémokines de type CXCL dans le comportement biologique de deux types de cancers naturellement résistants à l'apoptose, le cancer de l'oesophage et le gliome." Doctoral thesis, Universite Libre de Bruxelles, 2011. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209819.

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Le glioblastome qui correspond au stade de malignité le plus élevé des gliomes est associé à un très mauvais pronostic car il envahit le parenchyme cérébral de manière diffuse, ce qui rend son exérèse complète généralement impossible, et il résiste aux traitements conventionnels en raison de sa résistance intrinsèque aux stimuli pro-apoptotiques. Le cancer de l’œsophage est également un cancer très agressif car invasif et résistant également aux stimuli pro-apoptotiques. <p>Les chémokines sont des cytokines chémotactiques responsables de la migration des leucocytes et exprimées en réponse à de
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26

Etxaniz, Ulazia Olatz. "Investigación de las mutaciones de los genes de IDH1 y 2 en los gliomas de bajo grado." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/405523.

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El maneig dels gliomes de baix grau es basa en les característiques clíniques i radiològiques, incloent la classificació pronostica de Pignatti, que classifica als pacients com de baix o d'alt risc de recaiguda . Per determinar si les dades moleculars poden definir d’ una forma mes sensible el pronòstic dels pacient, hem examinat diverses alteracions moleculars en una cohort de 58 pacients. Hem registrat les dades clíniques i radiològiques que permeten obtenir la classificació pronòstica segons els criteris de Pignatti, i hem dut a terme l’estudi de les mutacions de IDH, les muta
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27

Soldatelli, Jéssica Silveira. "Efeitos da combinação de temozolomida e ditelureto de difenila em linhagens celulares de glioblastoma." reponame:Repositório Institucional da UCS, 2018. https://repositorio.ucs.br/11338/4064.

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Os gliomas representam mais de 70% dos tumores cerebrais primários. Os glioblastomas multiformes são gliomas malignos caracterizados por baixa incidência, mas altas taxas de mortalidade. Apesar da responsividade inicial ao tratamento padrão realizado com o quimioterápico alquilante temozolomida (TMZ), poucos foram os avanços para o prognóstico dos pacientes nos últimos 10 anos. Isso deve-se ao fato desses tumores serem raramente passíveis de ressecção cirúrgica e apresentarem alta taxa de recorrência. Além disso, a eficácia de seu tratamento encontra barreiras como efeitos colaterais indesejáv
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28

Montemor, José Paulo. "Uso do paclitaxel como potencializador da radioterapia em gliomas malignos cerebrais." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/17/17137/tde-29012007-214427/.

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O tratamento dos gliomas malignos cerebrais é um dos grandes desafios da medicina atualmente, pois, apesar do grande avanço no conhecimento destes tumores, o prognóstico de vida dos portadores desta doença é muito ruim. Foram estudados retrospectivamente 61 pacientes com diagnóstico de glioblastoma multiforme ou astrocitoma anaplásico, no período de 1998 a 2002, com o objetivo de avaliar o uso do Paclitaxel como potencializador do tratamento radioterápico destes tumores. Todos os pacientes foram tratados inicialmente com cirurgia para retirada ampla do volume tumoral (mínimo de 80%) seguido de
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29

Kenney-Herbert, Emma Mary. "Molecular and cellular characterisation of human glioblastoma tumour-initiating cell lines." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608958.

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Anjos, Marcos Antonio dos. "Efeito da derrota social sobre a progressão do glioma C6 inoculado no cérebro de ratos." Florianópolis, SC, 2002. http://repositorio.ufsc.br/xmlui/handle/123456789/83562.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.<br>Made available in DSpace on 2012-10-20T01:09:47Z (GMT). No. of bitstreams: 0<br>Neste estudo foi avaliado o efeito da derrota social sobre a progressão tumoral de células de glioma C6 inoculadas no cérebro de ratos. Os animais foram divididos em 4 grupos: inoculados com salina (grupo S, controle), inoculados com glioma C6 (grupo I), inoculados com glioma e depois submetidos a dupla derrota social (grupo I/D) e derrotados e depois inoculados com glioma (
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Hesselager, Göran. "A Short Thesis about Growth Factors in Gliomas." Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3445.

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<p>Glioblastoma multiforme (GBM) is the most common form of primary brain tumor in humans. Its aggressive and infiltrative growth into the brain, and, at best, only partial sensitivity to radiotherapy and chemotherapy, renders it extremely difficult to treat and survival remains dismal. </p><p>Growth factors, such as platelet-derived growth factor (PDGF) and epidermal growth factor (EGF), and their corresponding receptors are seen in glioma tissue, suggesting the presence of autocrine stimulatory loops. <i>PDGFB</i> and a mutated EGF receptor were also identified as cellular homologues of two
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Groft, Lori Lynne. "Tissue inhibitors of metalloproteinases in human malignant gliomas." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0018/MQ48004.pdf.

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Hesselager, Göran. "A short thesis about growth factors in gliomas /." Uppsala : Acta Universitatis Upsaliensis Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3445.

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Bhatia, Prateek. "Identification and characterization of transporters in human gliomas." Thesis, University of Sunderland, 2013. http://sure.sunderland.ac.uk/4691/.

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Functional overexpression of the ATP binding cassette (ABC) transporters at the cell surface is thought to be responsible for clinical multidrug resistance (MDR) in tumours of the brain. Inhibition of ABC transporters by existing inhibitors has proven to be inconclusive. This research program hypothesized an alternative location for the ABC transporters in glioblastoma cells and also proposed to develop stationary phases for the identification of ABC transporters inhibitors. Expression profile investigation of P-glycoprotein (PGP), multidrug resistant protein 1 (MRP1), multidrug resistant prot
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Rababa`h, Qasim. "Perfusion MRI of gliomas - comparison of analysis methods." Thesis, Örebro universitet, Institutionen för hälsovetenskap och medicin, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-37302.

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Ellison, David William. "Cell proliferation, cell death, and differentiation in gliomas." Thesis, University of Southampton, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295912.

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Malley, Deborah Sarah. "A study of DNA methylation in adult gliomas." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610148.

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Kenning, Lawrence. "The prognostic value of advanced MR in gliomas." Thesis, University of Hull, 2014. http://hydra.hull.ac.uk/resources/hull:10865.

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This work examines the prognostic value of advanced MR at selected time points during the early stages of treatment in glioma patients. In this thesis, serial imaging of glioma patients was conducted using diffusion tensor imaging (DTI), dynamic contrast enhanced (DCE) and dynamic susceptibility contrast (DSC) MRI. A methodology for the processing and registration of multiparametric MRI was developed in order to simultaneously sample whole tumour measurements of multiple MR parameters with the same volume of interest. Differences between glioma grades were investigated using functional MR para
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Marra, Joana Spaggiari. "Sobrevida após radioterapia para gliomas de alto grau." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17159/tde-04012017-143005/.

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Sobrevida após radioterapia em pacientes com glioma de alto grau Introdução: Gliomas de alto grau são os principais tumores primários do sistema nervoso central em adultos, cujo prognóstico permanece invariavelmente ruim, mesmo com a terapia atual: cirurgia e quimioirradiação. Na radioterapia utiliza-se de técnicas conformacionais (3DRT) e de intensidade modulada do feixe (IMRT). Objetivos: Avaliar a sobrevida dos pacientes tratados na instituição e os fatores que influenciam os resultados. Métodos: Análise retrospectiva dos tratamentos terapêuticos de pacientes diagnosticados com gliomas de a
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Fedrigo, Carlos Alexandre. "Inibi??o da via PI3K-Akt em gliomas." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2012. http://tede2.pucrs.br/tede2/handle/tede/1696.

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Made available in DSpace on 2015-04-14T13:35:33Z (GMT). No. of bitstreams: 1 439149.pdf: 1490829 bytes, checksum: bd616615ee5265db0a960d6f77c8581d (MD5) Previous issue date: 2012-05-29<br>Glioblastoma multiforme (GMB) is the most malignant and common type of all astrocytic tumours. Current standard treatment for GBM patients involves maximum surgical resection of the tumour, followed by radiotherapy and chemotherapy, usually containing the alkylating agent Temozolomide (TMZ). Despite this aggressive combination therapy, the survival rate of GBM patients is still low. This work consisted in i
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Tehranipour, Pegah. "Treatment outcomes on malignant gliomas using oncolytic viruses." Thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-412395.

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Purpose: The objective of this thesis is to evaluate clinical studies that have used oncolytic viruses as treatment and to compare their treatment-outcomes on patients with malignant glioma. Method: This thesis is a systematic literature review where PubMed has been used as the database for data collection. Two searches were done using the search phrases oncolytic virus AND Glioma and oncolytic virus AND brain tumor. Several of the articles showed up multiple times in different searches. After having applied the inclusion criteria, ten of the seventeen articles were removed. Remaining were sev
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Tzeng, Jone-Jiun. "Immunobiological and immunotherapeutic aspects of transplantable rat gliomas /." The Ohio State University, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487683756124386.

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Su, Zhangjie. "Translocator protein expression and microglial activation in gliomas." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/translocator-protein-expression-and-microglial-activation-in-gliomas(c3c60fb7-433f-4209-bf5e-d2741e1cf9e4).html.

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Background: Gliomas are the most frequent primary brain tumours in adults with two main histological subtypes: astrocytoma and oligodendroglioma. Translocator protein (TSPO) is a pro-inflammatory molecule over-expressed predominantly in activated microglia under pathological conditions. In astrocytoma samples, TSPO has also been found to be up-regulated and correlated with the malignancy of the tumours. [11C]-(R)PK11195 is a selective radioligand for the TSPO widely applied in clinical PET studies. We used [11C]-(R)PK11195 PET to investigate in vivo cerebral TSPO expression and microglial acti
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ALESSANDRINI, FRANCESCO. "Targeting high grade gliomas in murine preclinical models." Doctoral thesis, Università degli studi di Genova, 2018. http://hdl.handle.net/11567/929621.

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Broggi, M. A. "FLUORESCEIN-GUIDED SURGERY FOR RESECTION OF MALIGNANT GLIOMAS." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/233145.

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Introduction: Fluorescein is widely used as a fluorescent tracer for many applications. Its capability to accumulate in cerebral areas with blood-brain barrier damage makes it an ideal dye for intraoperative visualization of high-grade gliomas (HGG). This study presents a new fluorescein-guided technique to remove HGG with a dedicated filter on the surgical microscope (FLUOGLIO trial). Methods: The FLUOGLIO study is a prospective phase II-trial to evaluate safety and obtain initial indications about efficacy of fluorescein-guided surgery for HGG. Since September 2011, 24 patients (age ra
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46

Laurenge-Leprince, Alice. "Impact of D-2HG on the Tumor Microenvironment of IDH-mutated Gliomas." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL096.

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Contexte : Les gliomes diffus sont les tumeurs primitives malignes du système nerveux central les plus fréquentes. Certains présentent une mutation du gène codant pour l'isocitrate déshydrogénase 1 ou 2 (IDH) qui leur confère la néo-activité de transformer l'alpha-cétoglutarate (α-KG) produit par l'enzyme non mutée en D-2hydroxyglutarate (D-2HG). L'accumulation de cet oncométabolite entraîne l'inhibition compétitive des dioxygénases dépendantes de l'α-KG, incluant la famille TET (Ten Eleven Translocase) des ADN hydroxylases, et les JmjC/KMDs histone déméthylases, qui conduit elle-même à l'hype
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Ribom, Dan. "In Search of Prognostic Factors in Grade 2 Gliomas." Doctoral thesis, Uppsala University, Neurology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2789.

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<p>Grade 2 gliomas are malignant brain tumours affecting otherwise healthy adults. Although the long-term prognosis is poor, many patients are well and may have a high quality of life for several years. There is, however, a large variability in the natural course of the disease which makes it essential to identify patients who might benefit from early surgery or radio-therapy. The aim of the present thesis was to define new and clinically useful prognostic markers that may assist in the initial treatment decision and in patient follow-up.</p><p>A retrospective study of 189 patients with glioma
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Agarwal, Abhiruchi. "Nanocarrier mediated therapies for the gliomas of the brain." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/39468.

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Existing methods of treating glioma are not effective for eradicating the disease. Therefore, new and innovative methods of treatment alone or in combination with existing therapies are necessary. Delivery of therapeutic agents through delivery carriers such as liposomes diminishes the harmful effects of the agent in healthy tissues and allows increased accumulation in the tumor. In addition, targeted chemotherapy using liposomes provides the opportunity for further increase in drug accumulation in tumor. However, the current targeting strategies suffer accelerated plasma clearance and are not
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Baltuch, Gordon Hirsh. "Protein kinase C and growth regulation in malignant gliomas." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28984.

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Malignant gliomas represent over 50% of the tumours which originate within the central nervous system. Current treatment modalities are in large part unsuccessful, and less than 10% of patients with high grade glioblastomas survive beyond 2 years. Understanding the cause of the rapid growth rate of malignant gliomas would be useful in devising new therapeutic strategies to treat this disorder. Previous work from this laboratory suggested that the enzyme protein kinase C (PKC) was a critical regulator of the hyperproliferative state of glioma cells. The results presented in this thesis demonstr
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Lazow, Margot A. "Characterizing Temporal Genomic Heterogeneity in Pediatric Low-Grade Gliomas." University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1623166967779353.

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