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Journal articles on the topic 'Gliomi'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Laigle-Donadey, F., and A. Duran-Peña. "Gliomi del tronco cerebrale dell’adulto." EMC - Neurologia 19, no. 2 (2019): 1–13. http://dx.doi.org/10.1016/s1634-7072(19)42022-9.

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2

Turazzi, S. "Principi di chirurgia dei gliomi." Rivista di Neuroradiologia 16, no. 1_suppl (2003): 181–82. http://dx.doi.org/10.1177/19714009030160s171.

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3

Darlix, A., V. Rigau, and H. Duffau. "Neoformazioni intracraniche: gliomi di grado II." EMC - Neurologia 20, no. 4 (2020): 1–14. http://dx.doi.org/10.1016/s1634-7072(20)44227-8.

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4

Roux, A., and J. Pallud. "Gravidanza e gliomi diffusi di basso grado." EMC - Neurologia 18, no. 1 (2018): 1–8. http://dx.doi.org/10.1016/s1634-7072(17)87847-8.

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5

Bradač, G. B., A. Riva, S. Sales, and G. Stura. "Chemioterapia arteriosa nel trattamento dei gliomi maligni." Rivista di Neuroradiologia 7, no. 1_suppl (1994): 193–95. http://dx.doi.org/10.1177/19714009940070s139.

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Smaltino, F., R. Ruggiero, F. Fortunato, O. Catalano, and A. Frusciante. "La radiochirurgia stereotassica dei gliomi ad alto grado." Rivista di Neuroradiologia 7, no. 1_suppl (1994): 263–68. http://dx.doi.org/10.1177/19714009940070s151.

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7

Scerrati, M., P. Montemaggi, R. Roselli, M. Iacoangeli, A. Pompucci, and G. F. Rossi. "La brachiterapia interstiziale nel trattamento dei gliomi cerebrali." Rivista di Neuroradiologia 7, no. 1_suppl (1994): 275–76. http://dx.doi.org/10.1177/19714009940070s153.

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8

Piana, C., U. Pasquini, F. Menichelli, M. De Nicola, F. Bevilacqua, and U. Salvolini. "Chemioterapia endoarteriosa con ACNU (Nimustin) nei gliomi cerebrali maligni." Rivista di Neuroradiologia 5, no. 4_suppl (1992): 83–89. http://dx.doi.org/10.1177/19714009920050s410.

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Piana, C., U. Pasquini, F. Menichelli, M. De Nicola, and F. Bevilacqua. "Chemioterapia endoarteriosa con ACNU (Nimustin) nei gliomi cerebrali maligni." Rivista di Neuroradiologia 7, no. 1_suppl (1994): 189–91. http://dx.doi.org/10.1177/19714009940070s138.

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10

Ruggiero, G., A. Bacci, and R. Ricci. "Identificazione della natura istologica deigliomi cerebrali con tomografia computerizzata." Rivista di Neuroradiologia 2, no. 3 (1989): 267–71. http://dx.doi.org/10.1177/197140098900200308.

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Gli autori si propongono di verificare l'utilità rispettiva della biopsia e della radiologia per identificare il grado di malignità dei gliomi cerebrali. L'esame critico della letteratura dimostra che la biopsia effettuata su materiale chirurgico è più affidabile di quella sterotassica, ma che comunque essa non è esente da errori tecnici o diagnostici e da pericoli. La TC è utile e non inferiore, anzi non raramente superiore, alla RM. In una ricerca personale condotta su 123 casi verificati istologicamente, la TC, riesaminata dallo stesso neuroradiologo senza conoscenza della diagnosi, senza e

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11

Olaofe, O. O., B. A. Adewara, C. C. Okongwu, and E. E. Ewoye. "Case report: A case report of optic nerve glioma in a 5-year-old African girl." Research Journal of Health Sciences 12, no. 1 (2024): 82–87. http://dx.doi.org/10.4314/rejhs.v12i1.10.

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Background: Optic nerve gliomas are rare tumors that constitute less than 5% of all pediatric central nervous system tumors. Case Presentation: We present the case of a 5-year-old girl with complaints of progressive protrusion of the right eye and poor vision of 3 years duration who was referred to the ophthalmologist. Ophthalmological evaluation of the right eye revealed tearing, no perception of light, inferior dystopia, severe proptosis, and a firm non-tender orbital mass palpable posterior to the eyeball. The cranial CT-scan was suggestive of a right optic nerve glioma. Histology sho

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12

Piana, C., U. Pasquini, M. De Nicola, et al. "Chemioterapia endo-arteriosa con ACNU (Nimustin) nei gliomi cerebrali maligni." Rivista di Neuroradiologia 3, no. 2 (1990): 153–63. http://dx.doi.org/10.1177/197140099000300202.

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13

Brada , G. B., A. Riva, R. Soffietti, G. Stura, and D. Schiffer. "Chemioterapia arteriosa selettiva con BCNU nelle recidive dei gliomi maligni." Neuroradiology Journal 5, no. 1 (1992): 107–13. http://dx.doi.org/10.1177/197140099200500113.

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14

Rudà, R., C. Mocellini, R. Soffietti, et al. "Trattamento delle recidive di gliomi maligni con radioterapia stereotassica: Risultati preliminari." Rivista di Neuroradiologia 7, no. 1_suppl (1994): 279–80. http://dx.doi.org/10.1177/19714009940070s155.

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15

Jenko, Urša, Milica Stefanović, Barbara Faganel Kotnik, and Lidija Kitanovski. "GLIOMI NIZKEGA GRADUSA PRI OTROCIH IN ZDRAVLJENJE Z INHIBITORJI MEK – PRIKAZ PRIMERA." Slovenska pediatrija, revija pediatrov Slovenije in specialistov šolske ter visokošolske medicine Slovenije 30, no. 3 (2023): 131–36. http://dx.doi.org/10.38031/slovpediatr-2023-3-03.

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16

Colombo, F., A. Benedetti, P. Dettori, et al. "Radiochirurgia con acceleratore lineare: 5 anni di esperienza clinica." Rivista di Neuroradiologia 1, no. 1 (1988): 17–35. http://dx.doi.org/10.1177/197140098800100104.

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Gli autori utilizzano una tecnica di radiochirurgia con acceleratore lineare dal 1982. La tecnica è basata su irradiazioni multiple ad archi intersecantisi focalizzate stereotassicamente su un bersaglio. Dopo che una valutazione meccanica e dosimetrica ha dimostrato la validità della procedura, la tecnica è stata impiegata su un gruppo selezionato di pazienti. Dal novembre 1982 al marzo 1988 sono stati trattati 155 casi. Tra loro 72 erano affetti da malformazioni arterovenose cerebrali, 16 da gliomi a bassa malignità, 8 da neurinoma dell'acustico, 8 da meningiomi e 11 da tumori maligni radiose

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17

Munari, C., D. Hoffmann, P. P. Quarato, et al. "Biopsie seriate stereotassiche e correlazioni con TC ed RM nei gliomi a lento accrescimento." Rivista di Neuroradiologia 7, no. 1_suppl (1994): 75–82. http://dx.doi.org/10.1177/19714009940070s114.

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18

Floris, R., G. L. Sergiacomi, E. Squillaci, et al. "Il ruolo della risonanza magnetica nella diagnosi delle neurofibromatosi." Rivista di Neuroradiologia 5, no. 1_suppl (1992): 101–4. http://dx.doi.org/10.1177/19714009920050s120.

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Gli autori prendono in considerazione il ruolo diagnostico della risonanza magnetica nella diagnostica delle neurofibromatosi, su una casistica di 13 osservazioni, di cui 9 casi di NF1 e 4 NF2. Lo studio è stato eseguito mediante sistemi RM superconduttivi da 0,5 e 1,5 Tesla, osservando un pattern di aspetti polimorfo comprendente nelle NF1 lesioni multiple insieme in T1 (6 casi), iperintense in T1 (2 casi), sempre iperintense in T2; inoltre si sono riscontrati gliomi delle vie ottiche (3 casi), xantogranulomatosi dei plessi corioidei e neurinomi multipli cervicodorsali. Nelle NF2 si sono inve

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19

Delin, Sanja, Katarina Bošnjak Nađ, Mladen Harapin, Zoran Sessa, and Zlatko Juratovac. "Idiopatski spasmus nutans." Paediatria Croatica 57, no. 2 (2013): 177–82. http://dx.doi.org/10.13112/pc.690.

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Spasmus nutans rijedak je idiopatski poremećaj koji se javlja u dojenčadi i male djece (najčešće između 4.-12. mjeseca života) i spontano prolazi nakon nekoliko mjeseci ili godina. Spasmus nutans uključuje klinički trijas: torticolis, klimanje glavom i nistagmus koji jeobično unilateralan, horizontalan, velike brzine i niske amplitude. Isti simptomi mogu biti udruženi i s ozbiljnim okularnimporemećajima poput strabizma, refrakcijskih anomalija, ambliopije, infantilnog idiopatskog nistagmusa, retinalnih bolesti (albinizam, akromatopsija, kongenitalno stacionarno noćno sljepilo) ili intrakranijs

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20

Piovan, E., A. Beltramello, M. C. Spiller, et al. "Tumori della regione pineale. È possibile una distinzione sulla base dell'iconografia?" Rivista di Neuroradiologia 2, no. 1 (1989): 43–53. http://dx.doi.org/10.1177/197140098900200105.

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Gli autori prendono in considerazione il valore degli esami neuroradiologici nella diagnosi delle lesioni espansive della regione pineale. I dati riportati in letteratura vengono confrontati con l'esperienza personale (15 casi) per trarre possibili considerazioni significative per la diagnosi di oncotipo. La prima distinzione va fatta tra le lesioni intrinseche della pineale e quelle delle strutture ad essa circostanti. Inquadrando il caso con considerazioni sul sesso del paziente, la sua età, la frequenza relativa dei vari istotipi tumorali e i segni neuroradiologici rilevati con TC e RM, è p

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21

Xia, He-chun, Zhan-feng Niu, Hui Ma, et al. "Deregulated Expression of the Per1 and Per2 in Human Gliomas." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 37, no. 3 (2010): 365–70. http://dx.doi.org/10.1017/s031716710001026x.

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Background:Growing evidence shows that the deregulation of the circadian clock plays an important role in the development of malignant tumors, including gliomas. However, the molecular mechanisms of genes controlling circadian rhythm in glioma cells have not been explored.Methods:Using reverse transcription polymerase chain reaction and immunohistochemistry techniques, we examined the expression of two important clock genes, Per1 and Per2, in 33 gliomas.Results:In this study, out of 33 gliomas, 28 were Per1-positive, and 23 were Per2-positive. The expression levels of Per1 and Per2 in glioma c

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22

Kim, Junhyung, Min Woo Park, Young Joon Park, et al. "miR-542-3p Contributes to the HK2-Mediated High Glycolytic Phenotype in Human Glioma Cells." Genes 12, no. 5 (2021): 633. http://dx.doi.org/10.3390/genes12050633.

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(1) Background: The elevation of glucose metabolism is linked to high-grade gliomas such as glioblastoma multiforme (GBM). The high glycolytic phenotype is associated with cellular proliferation and resistance to treatment with chemotherapeutic agents in GBM. MicroRNA-542-3p (miR-542-3p) has been implicated in several tumors including gliomas. However, the role of miR-542-3p in glucose metabolism in human gliomas remains unclear; (2) Methods: We measured the levels of cellular proliferation in human glioma cells. We measured the glycolytic activity in miR-542-3p knockdown and over-expressed hu

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23

Kim, Junhyung, Min Woo Park, Ju Won Ahn, et al. "TAMI-47. MIR-542-3P CONTRIBUTES TO THE HK2-MEDIATED HIGH GLYCOLYTIC PHENOTYPE IN HUMAN GLIOMA CELLS." Neuro-Oncology 23, Supplement_6 (2021): vi208. http://dx.doi.org/10.1093/neuonc/noab196.830.

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Abstract BACKGROUND The elevation of glucose metabolism is linked to high-grade gliomas such as glioblastoma multiforme (GBM). The high glycolytic phenotype is associated with cellular proliferation and resistance to treatment with chemotherapeutic agents in GBM. MicroRNA-542-3p (miR-542-3p) has been implicated in several tumors including gliomas. However, the role of miR-542-3p in glucose metabolism in human gliomas remains unclear. METHODS We measured the levels of cellular proliferation in human glioma cells. We measured the glycolytic activity in miR-542-3p knockdown and over-expressed hum

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24

Wang, Y. "P02.06.B CROSSTALK BETWEEN GLIOMA AND MYELOID SHAPES DISTINCT TUMOR MICROENVIRONMENT IN SPINAL CORD, BRAIN STEM AND CEREBRUM." Neuro-Oncology 26, Supplement_5 (2024): v35. http://dx.doi.org/10.1093/neuonc/noae144.109.

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Abstract BACKGROUND Occurring in the cerebrum, brainstem, and spinal cord, glioma are the most common primary malignant tumors in the central nervous system. Currently, there is a increasing understanding of the microenvironment of cerebral gliomas and brainstem gliomas, and clinical trials of immunotherapy for them are also ongoing. However, research on the microenvironment of spinal cord glioma is still lacking, Their immunotherapy potential deserve further exploration. MATERIAL AND METHODS We performed single-cell sequencing of fresh tissues from 8 cases of spinal cord DMG. Through integrat

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Comba, Andrea, Patrick J. Dunn, Anna E. Argento, et al. "Fyn tyrosine kinase, a downstream target of receptor tyrosine kinases, modulates antiglioma immune responses." Neuro-Oncology 22, no. 6 (2020): 806–18. http://dx.doi.org/10.1093/neuonc/noaa006.

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Abstract Background High-grade gliomas are aggressive and immunosuppressive brain tumors. Molecular mechanisms that regulate the inhibitory immune tumor microenvironment (TME) and glioma progression remain poorly understood. Fyn tyrosine kinase is a downstream target of the oncogenic receptor tyrosine kinase pathway and is overexpressed in human gliomas. Fyn’s role in vivo in glioma growth remains unknown. We investigated whether Fyn regulates glioma initiation, growth and invasion. Methods We evaluated the role of Fyn using genetically engineered mouse glioma models (GEMMs). We also generated

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26

Ikeno, Yuji. "Ethylnitrosourea-induced gliomas: a song in the attic?" Aging Pathobiology and Therapeutics 5, no. 2 (2023): 48–51. http://dx.doi.org/10.31491/apt.2023.06.111.

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It is essential to seek the underlying molecular mechanisms of glioma development, and critical to discover interventions that reduce the incidence and attenuate the growth of gliomas using a well-established in vivo experimental model because glioma is clinically one of the most difficult malignant tumors to treat. Ethylnitrosourea (ENU)-induced glioma in the rat has been extensively utilized as an experimental brain tumor model since the mid-1960s, however, the scientific value of ENU-induced glioma has been underappreciated mainly due to the recent development of transgenic mouse glioma mod

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Gisina, Alisa, Irina Kholodenko, Yan Kim, Maxim Abakumov, Alexey Lupatov, and Konstantin Yarygin. "Glioma Stem Cells: Novel Data Obtained by Single-Cell Sequencing." International Journal of Molecular Sciences 23, no. 22 (2022): 14224. http://dx.doi.org/10.3390/ijms232214224.

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Glioma is the most common type of primary CNS tumor, composed of cells that resemble normal glial cells. Recent genetic studies have provided insight into the inter-tumoral heterogeneity of gliomas, resulting in the updated 2021 WHO classification of gliomas. Thorough understanding of inter-tumoral heterogeneity has already improved the prognosis and treatment outcomes of some types of gliomas. Currently, the challenge for researchers is to study the intratumoral cell heterogeneity of newly defined glioma subtypes. Cancer stem cells (CSCs) present in gliomas and many other tumors are an exampl

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Amin, Samirkumar, Kevin Anderson, Beth Bourdreau, et al. "GENE-57. COMPARATIVE MOLECULAR LIFE HISTORY OF SPONTANEOUS CANINE AND HUMAN GLIOMA." Neuro-Oncology 21, Supplement_6 (2019): vi110. http://dx.doi.org/10.1093/neuonc/noz175.459.

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Abstract Diffuse gliomas are the commonest of malignant brain tumors with high-grade tumors carrying dismal prognosis. Preclinical models have proven themselves as poor predictors of clinical efficacy, attributed to the lack of a comparable tumor microenvironment. Comparative genomics of canine and human gliomas provide an attractive alternative modality to identify conserved drivers and underlying mutational processes of glioma as well as evaluate life history tradeoffs related to tissue context and aging that can shape type and relative timing of drivers in gliomagenesis. We performed a comp

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McClellan, Brandon, Ali Dabaja, Kaushik Banerjee, et al. "IMMU-19. MUTANT ISOCITRATE DEHYDROGENASE 1 IN GLIOMA CAUSES A REDUCTION IN ADENOSINERGIC PATHWAY SIGNALING WITHIN THE TUMOR MICROENVIRONMENT." Neuro-Oncology 25, Supplement_5 (2023): v145. http://dx.doi.org/10.1093/neuonc/noad179.0551.

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Abstract Glioma is one of the most aggressive cancers and represents approximately 80% of malignant brain tumors. The majority of CNS World Health Organization (WHO) grades 2-3 gliomas and a subset of high-grade gliomas (CNS WHO grade 4) harbor mutated isocitrate dehydrogenase 1 (IDH1R132H; mIDH1). Mutant IDH1 results in the accumulation of 2-hydroxyglutarate (2HG) which elicits profound changes in the glioma transcriptome/biology. Consequently, mIDH1 glioma patients have a significantly increased median survival compared to wildtype IDH1 patients. Recent data from our lab showed that mIDH1 gl

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Yu, Di, Qiuhui Xuan, Chaoqi Zhang, et al. "Metabolic Alterations Related to Glioma Grading Based on Metabolomics and Lipidomics Analyses." Metabolites 10, no. 12 (2020): 478. http://dx.doi.org/10.3390/metabo10120478.

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Gliomas are the most aggressive phenotypes of brain tumors and are classified into four grades according to the malignancy degree by the World Health Organization. Metabolic profiling can provide an overview of metabolic reprogramming at a specific stage of tumor initiation and development. Studies about metabolic alterations related to different grades of gliomas are helpful to understand the molecular mechanism for progression of glioma. In the current study, metabolomics and lipidomics analyses based on chromatography-mass spectrometry were performed on different grades of glioma tissues. D

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31

Barron, Tara, Belgin Yalçın, Aaron Mochizuki, et al. "CNSC-01. GABAERGIC NEURON-TO-GLIOMA SYNAPSES IN DIFFUSE MIDLINE GLIOMAS." Neuro-Oncology 25, Supplement_1 (2023): i11. http://dx.doi.org/10.1093/neuonc/noad073.044.

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Abstract High-grade gliomas include clinically and molecularly distinct subtypes that stratify by anatomical location into diffuse midline gliomas (DMG) such as diffuse intrinsic pontine glioma (DIPG) and hemispheric high-grade gliomas. Neuronal activity drives high-grade glioma progression both through paracrine signaling and direct neuron-to-glioma synapses. Glutamatergic, AMPA receptor-dependent synapses between neurons and malignant glioma cells have been demonstrated in both pediatric and adult high-grade gliomas, but neuron-to-glioma synapses mediated by other neurotransmitters remain la

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32

Jiang, Chongming, Evelien Schaafsma, Yanding Zhao, Thinh Nguyen, Kenneth Zhu, and Chao Cheng. "Abstract LB528: A microglia associated gene signature predicts survival risk in glioma patients." Cancer Research 82, no. 12_Supplement (2022): LB528. http://dx.doi.org/10.1158/1538-7445.am2022-lb528.

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Abstract Background: Gliomas are common tumors that affect the brain and spinal cord. A complex tumor microenvironment is one of the leading reasons for a poor prognosis in glioma patients. Microglia, as part of the immune microenvironment of gliomas, may facilitate glioma growth and invasion. However, the correlation between the microglia abundance and glioma prognosis has not been clarified. Method: Our goal was to examine the relationship between microglia abundance and glioma prognosis. We analyzed the single-cell RNA sequences of human and mouse glioma cells to identify microglia marker g

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Sánchez, Manuel Lisardo, Arturo Mangas, and Rafael Coveñas. "Glioma and Peptidergic Systems: Oncogenic and Anticancer Peptides." International Journal of Molecular Sciences 25, no. 14 (2024): 7990. http://dx.doi.org/10.3390/ijms25147990.

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Glioma cells overexpress different peptide receptors that are useful for research, diagnosis, management, and treatment of the disease. Oncogenic peptides favor the proliferation, migration, and invasion of glioma cells, as well as angiogenesis, whereas anticancer peptides exert antiproliferative, antimigration, and anti-angiogenic effects against gliomas. Other peptides exert a dual effect on gliomas, that is, both proliferative and antiproliferative actions. Peptidergic systems are therapeutic targets, as peptide receptor antagonists/peptides or peptide receptor agonists can be administered

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Jaraíz-Rodríguez, Myriam, Rocío Talaverón, Laura García-Vicente, et al. "Connexin43 peptide, TAT-Cx43266–283, selectively targets glioma cells, impairs malignant growth, and enhances survival in mouse models in vivo." Neuro-Oncology 22, no. 4 (2019): 493–504. http://dx.doi.org/10.1093/neuonc/noz243.

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Abstract Background Malignant gliomas are the most frequent primary brain tumors and remain among the most incurable cancers. Although the role of the gap junction protein, connexin43 (Cx43), has been deeply investigated in malignant gliomas, no compounds have been reported with the ability to recapitulate the tumor suppressor properties of this protein in in vivo glioma models. Methods TAT-Cx43266–283 a cell-penetrating peptide which mimics the effect of Cx43 on c-Src inhibition, was studied in orthotopic immunocompetent and immunosuppressed models of glioma. The effects of this peptide in br

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Nguyen, Hoang Dong, Phedias Diamandis, Michelle S. Scott, and Maxime Richer. "Deciphering of Adult Glioma Vulnerabilities through Expression Pattern Analysis of GABA, Glutamate and Calcium Neurotransmitter Genes." Journal of Personalized Medicine 12, no. 4 (2022): 633. http://dx.doi.org/10.3390/jpm12040633.

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Adult infiltrating gliomas are highly aggressive tumors of the central nervous system with a dismal prognosis despite intensive multimodal therapy (chemotherapy and/or radiotherapy). In this study, we studied the expression, methylation and interacting miRNA profiles of GABA-, glutamate- and calcium-related genes in 661 adult infiltrating gliomas available through the TCGA database. Neurotransmitter-based unsupervised clustering identified three established glioma molecular subgroups that parallel major World Health Organization glioma subclasses (IDH-wildtype astrocytomas, IDH-mutant astrocyt

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Tedeschi, G., N. Lundbom, R. Raman, et al. "L'aumento del segnale di colina coincide con la trasformazione maligna dei gliomi cerebrali: Studio longitidinale con imaging di spettroscopia protonica in risonanza magnetica." Rivista di Neuroradiologia 10, no. 2_suppl (1997): 18–19. http://dx.doi.org/10.1177/19714009970100s205.

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We tested the hypothesis that proton magnetic resonance spectroscopic imaging (1H-MRSI) can be used as a supportive diagnostic tool to differentiate clinically stable brain tumors from those progressing as a result of either low-to-high grade malignant transformation or of post-therapeutic recurrence. Twenty-seven patients with histologically verified cerebral gliomas were studied repeatedly with 1H-MRSI over a period of 3.5 years. At the time of each 1H-MRSI study, clinical examination, MRI, positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG), and biopsy findings (when availa

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Chen, Houminji, Ming Li, Yanwu Guo, et al. "Immune response in glioma’s microenvironment." Innovative Surgical Sciences 5, no. 3-4 (2020): 115–25. http://dx.doi.org/10.1515/iss-2019-0001.

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Abstract Objectives Glioma is the most common tumor of the central nervous system. In this review, we outline the immunobiological factors that interact with glioma cells and tumor microenvironment (TME), providing more potential targets for clinical inhibition of glioma development and more directions for glioma treatment. Content Recent studies have shown that glioma cells secrete a variety of immune regulatory factors and interact with immune cells such as microglial cells, peripheral macrophages, myeloid-derived suppressor cells (MDSCs), and T lymphocytes in the TME. In particular, microgl

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Gupta, Pravesh, Minghao Dang, Krishna Bojja, et al. "IMMU-35. TRANSCRIPTIONALLY DEFINED IMMUNE CONTEXTURE IN HUMAN GLIOMAS AT SINGLE-CELL RESOLUTION." Neuro-Oncology 22, Supplement_2 (2020): ii112. http://dx.doi.org/10.1093/neuonc/noaa215.465.

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Abstract The brain tumor immune microenvironment (TIME) continuously evolves during glioma progression and a comprehensive understanding of the glioma-centric immune cell repertoire beyond a priori cell types and/or states is uncharted. Consequently, we performed single-cell RNA-sequencing on ~123,000 tumor-derived immune cells from 17-pathologically stratified, IDH (isocitrate dehydrogenase)-differential primary, recurrent human gliomas, and non-glioma brains. Our analysis delineated predominant 34-myeloid cell clusters (~75%) over 28-lymphoid cell clusters (~25%) reflecting enormous heteroge

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Sears, Thomas, Michael Drumm, Wenxia Wang, and Craig Horbinski. "EXTH-28. ISOCITRATE DEHYDROGENASE MUTATIONS PREDICT SENSITIVITY TO HISTONE DEACETYLASE INHIBITION AND ENHANCED HISTONE ACETYLATION DYNAMICS ONLY IN THE CONTEXT OF GLIOMA." Neuro-Oncology 25, Supplement_5 (2023): v229—v230. http://dx.doi.org/10.1093/neuonc/noad179.0881.

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Abstract Isocitrate dehydrogenase 1/2 mutations (IDHmut) define a subtype of glioma with profound epigenetic dysregulation through genomic hypermethylation. IDHmut gliomas are incurable and fatal, demonstrating new treatments are needed. These mutations are common in other solid tumors, including chondrosarcoma (CS) and intrahepatic cholangiocarcinoma (ICC). Histone deacetylase (HDAC) enzymes compose a class of epigenetic drug targets utilized clinically to treat cancer, but their potential against IDHmut gliomas has not been extensively studied. We previously showed that IDHmut glioma culture

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K Petritsch, Claudia, Lulu Xing, and Brandon Bui. "TMOD-05. GLIOMA-ASSOCIATED OLIGODENDROCYTE PROGENITOR CELLS’ DYNAMIC PATTERNS SUGGEST FUNCTIONAL ADAPTATIONS DURING GLIOMA PROGRESSION IN A UNIQUE MOUSE MODEL." Neuro-Oncology 26, Supplement_8 (2024): viii319—viii320. http://dx.doi.org/10.1093/neuonc/noae165.1269.

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Abstract Gliomas account for more than one-third of brain tumors in children, with high fatality rate despite aggressive adjuvant treatment. Two-thirds of survivors suffer from health conditions due to the toxicity of conventional therapies. Notably, gliomas with the BRAFV600E mutation, occurring in ~20% of all glioma cases, are difficult to treat and have a high risk for progression, especially when combined with CDKN2A deletion. The mechanisms for glioma progression remain unclear and unraveling them could lead to therapies that inhibit glioma progression, preventing high-grade gliomas. Obje

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Fritah, S., A. Cano-Galiano, R. Toth, et al. "P02.18.B INTEGRATIVE OMICS ANALYSIS OF IDH1 MUTANT GLIOMA PATIENTS REVEALS ALTERATIONS IN BUTYRATE METABOLISM." Neuro-Oncology 25, Supplement_2 (2023): ii33—ii34. http://dx.doi.org/10.1093/neuonc/noad137.103.

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Abstract BACKGROUND Mutations in isocitrate dehydrogenase (IDH) 1 or 2 define glioma classification and determine the biology of these tumors. Although IDH is an essential enzyme in the cellular metabolism, powerful genome-wide analyses focus mostly at the genetic and epigenetic levels, while differences between distinct glioma entities at the proteomics, metabolomics, and functional levels are still poorly understood. Here, we provide an integrative multi-omics analysis of glioma patients to reveal metabolomic vulnerabilities of gliomas stratified by IDH mutation. MATERIAL AND METHODS We perf

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Zhao, Shiguang. "BIOM-63. DIAGNOSIS AND PROGNOSTIC SIGNIFICANCE OF CIRCULATING miR-2276-5p IN PLASMA OF GLIOMA PATIENTS." Neuro-Oncology 22, Supplement_2 (2020): ii15. http://dx.doi.org/10.1093/neuonc/noaa215.060.

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Abstract Circulating microRNAs (miRNAs) in plasma have the potential to become diagnostic and prognostic biomarkers for various cancers. This study hopes to use plasma circulating miRNAs as biomarkers for diagnosis and prognosis of glioma patients. METHOD: In this study, the plasma circulating miRNAs of 124 patients with glioma and 36 controls was collected to detect the relative expression of miR-2276-5p, and the specificity and sensitivity of the diagnosis were verified by ROC curve. The follow-up survival status was analyzed by cox regression analysis. RESULT: In the GSE 139031 database, it

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Wirth, Thomas, Farizan Ahmad, Agnieszka Pacholska, Haritha Samaranayake, and Seppo Ylä-Herttuala. "The Syngeneic BT4C Rat Malignant Glioma is a Valuable Model to study Myelomonocytic cells in Tumors." Cancer Growth and Metastasis 5 (January 2012): CGM.S9314. http://dx.doi.org/10.4137/cgm.s9314.

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Background The impact of infiltrating macrophages on tumor progression in malignant gliomas has been studied extensively. However, there is a lack of animal models for studying the role of infiltrating macrophages in malignant gliomas. Material and methods: The BT4C rat malignant glioma model was characterized by immunohistochemical analysis of inflammatory cell types associated with the tumors. Results BT4C malignant gliomas are highly vascularized tumors with an infiltrative behavior. BT4C gliomas demonstrated a high infiltration rate of macrophages. Particularly, a CD68/VEGFR-1 positive sub

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Gao, Huasong, Bin Yu, Yaohua Yan, et al. "Correlation of expression levels of ANXA2, PGAM1, and CALR with glioma grade and prognosis." Journal of Neurosurgery 118, no. 4 (2013): 846–53. http://dx.doi.org/10.3171/2012.9.jns112134.

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Object Biomarkers for the diagnosis and prognosis of gliomas are lacking. To elucidate new diagnostic and prognostic targets, a routine method is used to evaluate differences between the protein profile of normal and tumor cells. The object of the current study was to investigate novel differentially expressed proteins and their roles in gliomas. Methods Differences in the protein profile were compared using 2D polyacrylamide gel electrophoresis using C6 glioma cells and rat astrocytes. The mRNA and protein expression of ANXA2, PGAM1, and CALR were analyzed in glioma tissues and normal brain t

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Rao, Aparna, Xiaoran Zhang, Christopher Deibert, Paola Sette, Paola Grandi, and Nduka Amankulor. "IDH Mutant Gliomas Escape Natural Killer Cell Immune Surveillance by Downregulation of NKG2D Ligand Expression." Journal of Immunology 196, no. 1_Supplement (2016): 142.11. http://dx.doi.org/10.4049/jimmunol.196.supp.142.11.

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Abstract Background Diffuse gliomas are fatal primary brain tumors that are poorly immunogenic. The basis for insufficient anti-tumor immunity in diffuse gliomas is not understood. Mutations in isocitrate dehydrogenases (IDH1 and IDH2) promote diffuse glioma formation through epigenetic reprogramming of a number of genes, including immune-related genes. Here, we identify epigenetic dysregulation of natural killer (NK) cell ligand genes as significant contributors to immune escape in glioma. Methods We analyzed the TCGA database for immune gene expression patterns in IDH mutant or wild-type gli

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Pedersen, L. K. "P05.02.A 18F-FACBC PET/MRI in diagnostic assessment of gliomas." Neuro-Oncology 24, Supplement_2 (2022): ii36. http://dx.doi.org/10.1093/neuonc/noac174.121.

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Abstract Background and Theory MRI and histopathological tissue sampling are routinely done as part of the diagnostic work-up of patients with glioma. MRI provides anatomical images with high resolution and excellent soft-tissue contrast. But this modality has limitations in identifying tumor grade, true tumor extension and differentiate viable tumor tissue from treatment induced changes. PET can provide quantitative information of cellular activity and metabolism, and may therefore have additional value compared to MRI alone. Objective The aim of this study was to find the sensitivity of [18F

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Martynov, B. V., V. Ye Parfenov, D. V. Svistov, et al. "Influence of type and volume of surgical resection on postoperative period in patients with gliomas." Bulletin of Siberian Medicine 7, no. 5-1 (2008): 231–35. http://dx.doi.org/10.20538/1682-0363-2008-5-1-231-235.

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283 patients with gliomas were included in this study. Age, sex, neurological status and Karnovsky performance were analyzed before and after surgery, also tumor location, type and volume of surgical resection, postoperative complications were considered. Volume of tumor resection did not depend on glioma localization, excluding deep located tumors, in which case stereotactic cryotomy was performed (p < 0,01). In cases of stereotactic cryotomy postoperative neurological deficit worsening was noted in 12,5%, in patients with open biopsy and partial resection — 10,9%, and in case of total or

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Sun, Jin-Zhang, Jin-Hao Zhang, Jia-Bo Li, et al. "MXRA5 Is a Novel Immune-Related Biomarker That Predicts Poor Prognosis in Glioma." Disease Markers 2021 (June 9, 2021): 1–13. http://dx.doi.org/10.1155/2021/6680883.

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Background. Glioma is the most common primary intracranial tumor and is associated with poor prognosis. Identifying effective biomarkers for glioma is particularly important. MXRA5, a secreted glycoprotein, is involved in cell adhesion and extracellular matrix remodeling and has been reported to be expressed in many cancers. However, the role and mechanism of action of MXRA5 in gliomas remain unclear. This study was aimed at investigating the role of MXRA5 at the transcriptome level and its clinical prognostic value. Methods. In this study, RNA microarray data of 301 glioma patients from the C

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Nagashima, Yoshitaka, Yusuke Nishimura, Fumiharu Ohka, et al. "Driver Genetic Mutations in Spinal Cord Gliomas Direct the Degree of Functional Impairment in Tumor-Associated Spinal Cord Injury." Cells 10, no. 10 (2021): 2525. http://dx.doi.org/10.3390/cells10102525.

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Genetic analysis in glioma has been developed recently. Spinal cord glioma is less common than intracranial glioma. Thus, the clinical significance of genetic mutations in spinal cord gliomas remains unclear. Furthermore, because the spinal cord is an important communication channel between the brain and the rest of the body, increased attention should be paid to its functional prognosis. In this study, we investigated the functional prognosis and driver genetic mutations in eight patients with spinal cord gliomas (World Health Organization grade I, three cases; grade II, two cases; grade III/

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Kwikima, Ugumba. "GLIOMA-04 BRIDGING THE GAP ON ADULT GLIOMA IMAGING, DIAGNOSIS AND FOLLOW UP IN SUB-SAHARAN AFRICA." Neuro-Oncology Advances 5, Supplement_4 (2023): iv1. http://dx.doi.org/10.1093/noajnl/vdad121.003.

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Abstract Cerebral Gliomas are the most common and devastating primary brain tumors. Prior to 2016 WHO CNS tumor classification update, the grading of gliomas, mainly relied on histological features, including cellularity, nuclear atypia, mitotic activity, vascularity, and necrosis, observed on light microscopy with the aid of immunohistochemistry. A number of studies confirmed that diffuse gliomas demonstrates different growth pattern, clinical behavior, and prognostication based on their genomic alterations, these findings necessitated incorporation of molecular subtypes in glioma classificat

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