Academic literature on the topic 'Global 2000 Study (U.S.)'

AbstractA new Swiss glacier inventory is to be compiled from satellite data for the year 2000. The study presented here describes two major tasks: an accuracy assessment of different methods for glacier classification with Landsat Thematic Mapper (TM) data and a digital elevation model (DEM); the geographical information system (GIS)-based methods for automatic extraction of individual glaciers from classified satellite data and the computation of three-dimensional glacier parameters (such as minimum, maximum and median elevation or slope and orientation) by fusion with a DEM. First results obtained by these methods are presented in Part II of this paper (Kääb and others, 2002). Thresholding of a ratio image from TM4 and TM5 reveals the best-suited glacier map. The computation of glacier parameters in a GIS environment is efficient and suitable for worldwide application. The methods developed contribute to the U. S. Geological Survey-led Global Land Ice Measurements from Space (GLIMS) project which is currently compiling a global inventory of land ice masses within the framework of global glacier monitoring (Haeberli and others, 2000).

This study demonstrated that a simple mechanical model of global tongue movement in parallel sagittal planes could be used to quantify tongue motion during speech. The goal was to represent simply the differences in 2D tongue surface shapes and positions during speech movements and in subphonemic speech events such as coarticulation and left-to-right asymmetries. The study used tagged Magnetic Resonance Images to capture motion of the tongue during speech. Measurements were made in three sagittal planes (left, midline, right) during movement from consonants (/k/, /s/) to vowels (/i/, /a/, /u/). MR image-sequences were collected during the C-to-V movement. The image-sequence had seven time-phases (frames), each 56 ms in duration. A global model was used to represent the surface motion. The motions were decomposed into translation, rotation, homogeneous stretch, and in-plane shear. The largest C-to-V shape deformation was from /k/ to/a/. It was composed primarily of vertical compression, horizontal expansion, and downward translation. Coarticulatory effects included a trade-off in which tongue shape accommodation was used to reduce the distance traveled between the C and V. Left-to-right motion asymmetries may have increased rate of motion by reducing the amount of mass to be moved.

Background:Distinguishing primary NPSLE (neuropsychiatric systemic lupus erythematosus) from secondary causes remains challenging (1). Attribution models were developed in order to aim clinicians in correct classification of NPSLE cases (2).Objectives:To investigate the prevalence of primary NPSLE manifestations assigned with Italian model of attribution (2).Methods:We retrospectively assessed clinical details of 164 patients with SLE classified with 2012 SLICC (Systemic Lupus International Collaborating Clinics) classification criteria, 21 were excluded due to incomplete information. Data was gathered with a questionnaire comprising demographics, medical history, laboratory results (concentrations of antibodies against double stranded DNA – anti-dsDNA, complement components C3 and C4), disease activity measured with Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and Physician Global Assessment (PGA) and damage determined with SLICC/ACR (American College of Rheumatology) Damage Index (SDI). Neuropsychiatric manifestations were categorized in accordance with 1999 ACR glossary and attribution of manifestations was performed with the use of Italian model with the score ≥7 out of 10 points enabling assignment to primary NPSLE group (2). Statistical analysis was conducted with Statistica v.13.3 using Mann-Whitney U, chi-square and Fisher exact test.Results:We encountered 155 NP manifestations in our cohort and 52 (34%) were attributed to SLE. Characteristics of the study groups are presented in Table 1. Exact manifestations and their attribution rates are presented on Graph 1. Patients with attributable NPSLE were younger, had earlier disease onset, presented higher disease activity, lower damage accrual without taking NP damage into account and more often had increased anti-dsDNA serum concentration.Table 1.Demographic and laboratory characteristics with disease activity and damage of the study groups, N(%) or mean(±SD).CharacteristicPatients with attributed NPSLE manifestationsPatients without attributed NPSLE manifestationsPatients34 (23.8%)109 (76.2%)Sex, female30 (88.2%)102 (93.6%)Age (years)37.6 (±11.7)44.3 (±13.9)*Age of disease onset (years)32.5 (±11.4)37.6 (±12.6)*Disease duration (years)5.1 (±4.1)6.8 (±5.6)SLEDAI-2K29.2 (±10.7)12.2 (±8.1)*patients with clinically active disease (defined as SLEDAI-2K≥6 in clinical manifestations)34 (100%)93 (85.3%)*SLEDAI-2K without NP manifestations14.8 (±8.4)11.0 (±6.7)*PGA2.1 (±1.0)1.2 (±1.0)*SDI0.5 (±0.8)0.7 (±1.1)SDI without NP damage0.3 (±0.6)0.7 (±1.1)*low C3/C4 complement component concentration in serum21 (61.8%)55 (50.4%)elevated anti-dsDNA autoantibody concentration in serum27 (79.4%)55 (50.4%)*NPSLE – neuropsychiatric systemic lupus erythematosus, SLEDAI-2K – Systemic Lupus Erythematosus Disease Activity Index version 2000, PGA – physician global assessment, SDI – SLICC/ACR (Systemic Lupus International Collaborating Clinics/American College of Rheumatology) Damage Index*p<0,05, Mann-Whitney U, χ2or Fisher’s exact test, as appropriateConclusion:Primary NP manifestations in patients with SLE occur mainly in young patients with high disease activity. Cerebrovascular disease, seizures, psychosis and cranial neuropathy are most frequent primary NPSLE manifestations.References:[1]The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes. Arthritis Rheum. 1999;42(4):599–608.[2]Bortoluzzi A, Scirè CA, Bombardieri S, Caniatti L, Conti F, De Vita S, et al. Development and validation of a new algorithm for attribution of neuropsychiatric events in systemic lupus erythematosus. Rheumatol Oxf Engl. 2015;54(5):891–8.Disclosure of Interests:None declared

Abstract Abstract 2986 Poster Board II-962 Introduction: The protein C pathway is believed to be a crucial regulator of coagulation. Similar to the adult population, it is of utmost importance in pediatric patients to maintain the balance between pro- and anticoagulatory signals (Petaja and Manco-Johnson 2003). Cancer patients have been shown to have cancer and cancer-therapy associated pathologies of the protein C pathway. (Nijziel, van Oerle et al. 2003; Woodley-Cook, Shin et al. 2006). A test evaluating the response of the protein C pathway after activation of endogenous protein C has been shown to be a sensitive tool to screen for protein C deficiency and APC resistance whereas protein S deficiency is detected less reliably (Toulon, Halbmeyer et al. 2000). This is in line with findings suggesting that any pathology of this assay is related to an increased risk of VTE, independent of the pathology related to the abnormality of the test result (Toulon, Perez et al. 2007). Similarly, patients with idiopathic pregnancy loss were found to have a pathological response independent of the pathology related (Sarig, Lanir et al. 2002). Methods: We therefore evaluated the influence of different variables on the results of the global protein C assay (Pro C Global on a BCS analyzer, Siemens, Marburg, Germany) in 431 children enrolled into the Thrombotect study. The Thrombotect study is a prospective, randomized trial evaluating unfractionated heparin vs low molecular weight heparin vs antithrombin replacement for prevention of thromboembolism in children undergoing asparaginase containing chemotherapy for acute lymphoblasic leukaemia within the BFM protocol. A multivariate linear regression analysis on results obtained before treatment was performed (MedCalc 10.0.1). Results: To date (as of 8/09), 720 children have been randomized in the Thrombotect trial. At the time, we had complete data for laboratory evaluation available for 431 children on day 0 of the treatment protocol. Free protein S, IgG antibodies against cardiolipin or phosphatidlyserine, dRVVT, fibrinogen, the presence of F II G20210A, homocystein concentration, Lp(a) concentration and PAI-1 activity had no predictive value towards the protein C pathway assay result in this multivariate analysis. In contrast, the protein C pathway activity was expectedly shown to be dependent on the presence of the F V Leiden mutation (p<0.0001), protein C activity (p<0.0001) and F VIIIc (p=0.0001). Unexpectedly, the protein C pathway activity was also dependent on antithrombin activity (p=0.0166), F XIIc (p=0.0137) and IgM (but not IgG) antibodies against cardiolipin (p=0.0304) and phosphatidylserine (p=0.0006) in this multivariate analysis. Importantly, the association between protein C pathway activity and the “unexpected” predictors were independent of whether or not the results were in the reference range or not (median [95% CI] antithrombin activity 0.95 [0.93-0.97], median F XIIc 0.94 [0.90-0.98], median ACL IgM 2 [2-3] U/ml, median APS IgM 2 [2-3] U/ml). Conclusions: The protein C pathway is believed to be a crucial regulatory element of haemostasis. Our results from a large cohort (n = 431) of children with ALL and thus at risk for thromboembolism indicate that the protein C pathway is -expectedly (such as F V Leiden mutation, protein C activity, F VIIIc) and unexpectedly (such as antithrombin activity and the concentration of antiphospholipid IgM antibodies) - interdependent with many other variables of the coagulation system. These data provide evidence that the protein C pathway ex vivo in children with ALL is targeted by various elements of other haemostasis pathways in a significant manner in multivariate analysis. Disclosures: No relevant conflicts of interest to declare.

This study sought to characterize the relationship among voluntary rate modification, vocal tract acoustic output, and perceptual impressions of speech for individuals with idiopathic Parkinson disease (PD). Healthy control speakers were studied for comparison purposes. Four research questions were addressed: (1) How is rate modification evidenced in acoustic measures of segmental and global timing? (2) What is the impact of rate modification on measures of acoustic working space for select vowels and consonants? (3) What is the impact of rate modification on perceptual impressions of severity? (4) Are rate-induced changes in measures of acoustic working space related to perceptual impressions of severity? Speakers read the Farm Passage at habitual, slow, and fast rates. The vowels /i/, /æ/, /u/, and /a/ and the fricatives /s/ and /∫/ were of interest. Acoustic measures included articulatory rate, segment durations, vowel formant frequencies, and first moment coefficients. Measures of acoustic working space for vowels and fricatives also were derived. The results indicated that temporal acoustic measures changed in the expected direction across rate conditions, with a tendency toward slightly faster rates for the PD group. In addition, the relative rate change for the Fast and Slow conditions compared to the Habitual condition was similar across groups. Rate did not strongly affect measures of acoustic working space for the PD group as a whole, but there was a tendency for slower rates to be associated with larger measures of acoustic working space. Finally, there was not a strong relationship between perceived severity and measures of acoustic working space across the rate continuum for either group. Rather, the relationship between perceived severity and measures of acoustic working space was such that the PD group exhibited smaller measures of acoustic working space and more severe perceptual estimates than the control speakers, irrespective of rate condition.

The achievement of family well - being is an aspiration of all families including families of migrant workers, to achieve the well - being of one of the ways that the families of migrant workers with the departure of the wife work as domestic servants in various countries. The purpose of this study was to analyze social capital, economic coping, sress symptom’s husband and family subjektive well - being of women migrant workers. This research use cross sectional studies. The location was chosen purposively in Tanggeung Village, Pagermaneuh Village, Margaluyu Village, Karangtengah Village, Tanggeung District and Pasirdalam Village Kadupandak District, Cianjur, West Java, Indonesia. Seventy five families were selected purposively among the families of women migrant workers. The finding indicates that social capital is in the moderate category, the coping economy is in the moderate category, the sress symptom’s husband is in the low category and the family well-being is in the low category. Finding in this study family subjective well-being is influenced by income per capita, sress symptom’s husband and economic coping.
 Keywords: economic coping, family subjective well-being, social capital, stress symptom
 
 Abstrak
 Kesejahteraan keluarga merupakan sesuatu yang ingin dicapai seluruh keluarga, termasuk keluarga Tenaga Kerja Wanita (TKW), untuk mencapai kesejahteraan tersebut salah satu cara yang dilakukan oleh keluarga TKW adalah mengirim istri sebagai pembantu rumah tangga di berbagai negara. Tujuan dari penelitian ini adalah untuk menganalisis modal sosial, coping ekonomi, gejala stres suami, dan kesejahteraan subjektif keluarga TKW. Penelitian ini menggunakan cross sectional studies. Lokasi dipilih dengan metode purposive di Provinsi Jawa Barat, Kabupaten Cianjur, Kecamatan Tanggeung, Desa Pagermaneuh, Desa Marguluyu, Desa Karangtengah, Desa Tanggeung, Kecamatan Kadupandak, Desa Pasirdalam. Jumlah sampel sebanyak 75 keluarga TKW dengan metode purposive sampling. Penelitian ini menemukan modal sosial berada pada kategori sedang, coping ekonomi berada pada kategori sedang, gelaja stres suami berada pada kategori rendah, dan kesejahteraan subjektif berada pada kategori rendah. Penelitian ini juga menemukan kesejahteraan keluarga berpengaruh terhadap pendapatan perkapita, gelaja stres suami, dan coping ekonomi.
 Kata kunci : coping ekonomi, gejala stres, kesejahteraan subjektif, modal sosial.
 
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AbstractThe non-local equation$$ u_t=(u^3u_x)_x+\frac{\lambda f(u)}{(\int_{-1}^1f(u)\,\rd x)^{2}} $$is considered, subject to some initial and Dirichlet boundary conditions. Here $f$ is taken to be either $\exp(-s^4)$ or $H(1-s)$ with $H$ the Heaviside function, which are both decreasing. It is found that there exists a critical value $\lambda^*=2$, so that for $\lambda>\lambda^{*}$ there is no stationary solution and $u$ ‘blows up’ (in some sense). If $0\lt\lambda\lt\lambda^{*}$, there is a unique stationary solution which is asymptotically stable and the solution of the IBVP is global in time.AMS 2000 Mathematics subject classification: Primary 35B30; 35B35; 35B40; 35K20; 35K55; 35K99

AbstractIn this work, the behaviour of solutions for the Dirichlet problem of the non-local equation$$ u_t=\varDelta(\kappa(u))+\frac{\lambda f(u)}{(\int_{\varOmega}f(u)\,\mathrm{d}x)^p},\quad \varOmega\subset\mathbb{R}^N,\quad N=1,2, $$is studied, mainly for the case where $f(s)=\mathrm{e}^{\kappa(s)}$. More precisely, the interplay of exponent $p$ of the non-local term and spatial dimension $N$ is investigated with regard to the existence and non-existence of solutions of the associated steady-state problem as well as the global existence and finite-time blow-up of the time-dependent solutions $u(x,t)$. The asymptotic stability of the steady-state solutions is also studied.AMS 2000 Mathematics subject classification: Primary 35K60. Secondary 35B40

AbstractWe study a three parameter deformation $\mathcal{U}_{abc}$ of $\mathcal{U}(\mathfrak{sl}_2)$ introduced by Le Bruyn in 1995. Working over an arbitrary algebraically closed field of characteristic zero, we determine the centres, the finite-dimensional irreducible representations, and, when the parameter $a$ is not a non-trivial root of unity, the prime ideals of those $\mathcal{U}_{abc}$, with $ac\neq0$, which are conformal as ambiskew polynomial rings.AMS 2000 Mathematics subject classification: Primary 16W35; 17B37. Secondary 16S36; 16S80

The case for global risk diversification has been built on correlations between the U.S. and international stock markets. Now that we witness how tightly the world stock markets are correlated, especially after the global financial crisis of 2008-2009, does it still make sense to diversify globally? Can the investments in global equity portfolios be protected in todays volatile markets? These questions have preoccupied a growing number of portfolio managers in recent years, as well as many of us who invest in stock markets. Since gold/silver and bonds tend to move inversely with the stock markets, a hedging strategy of combining them with stock portfolios should protect the equity investments during global market downturns. The study explores the risk-return profiles of various global portfolios and provides insights about the extent to which the U.S. investors need to allocate their investments in Asia/Pacific, European stock markets, and across other investment vehicles, such as gold/silver and bonds. The findings from this research have practical implications for both investors and portfolio managers interested in going global.

Scholars have identified community colleges as ideal institutions to facilitate global justice through their involvement in internationalization activities such as study abroad. This chapter explores the meaning of humanism as it relates to study abroad at the community college. Using Andreotti, Stein, Pashby, and Nicolson's Paradigms of Discourse, the chapter describes the ways in which humanism can be defined in a variety of ways based on one's own goals. The chapter also grounds a rationale for study abroad at the community college within critical humanism by applying Young's Social Connections Model. Finally, the chapter applies the critical humanist rationale to begin to question the relationship between community college study abroad initiatives: Who is included in the community mission? Whose cultures come to be understood from involvement in study abroad? How are U. S. cultures represented by study abroad?

The persistently large income gap between the Developed Countries (DCs) of the North and relatively Less Developed and Developing Countries (LDDCs) of the South is one of the most notable features of the international community over the last few decades. Such large disparities in income are paralleled by huge gaps in other non-monetary indicators of well being. Different research works in this field have indicated that the average annual growth rate of per capita income in LDDCs has been faster compared to that in DCs particularly since early 1990s indicating a sign of convergence in the growth process. However, the absolute gap between the DCs and LDDCs in terms of per capita GNP has widened over years. In this chapter, an attempt has been made to indicate the pattern of ß-convergence and s- convergence in income growth between DCs and LDDCs during 1960-2012. The study observes that there remains a definite indication of ß and s convergence in the growth rate of real PCI across different groups of nations particularly during the period 2000-2013.

Scholars have identified community colleges as ideal institutions to facilitate global justice through their involvement in internationalization activities such as study abroad. This chapter explores the meaning of humanism as it relates to study abroad at the community college. Using Andreotti, Stein, Pashby, and Nicolson's Paradigms of Discourse, the chapter describes the ways in which humanism can be defined in a variety of ways based on one's own goals. The chapter also grounds a rationale for study abroad at the community college within critical humanism by applying Young's Social Connections Model. Finally, the chapter applies the critical humanist rationale to begin to question the relationship between community college study abroad initiatives: Who is included in the community mission? Whose cultures come to be understood from involvement in study abroad? How are U. S. cultures represented by study abroad?

This study of La Salada, renamed by Cuartel’s residents as the “poor people’s shopping mall,” was founded in the early 1990’s at the height of neoliberalism by several dozen undocumented Bolivian immigrants and Argentine street hawkers in a pauperized, stigmatized and disenfranchised district near the city of Buenos Aires. By the early 2000’s, La Salada occupied a central place in public life in Cuartel and beyond; the European Union described it as “emblematic of counterfeit markets,” among the ten worst of its kind. In studying this market and the network of satellite ‘Saladitas’ that have proliferated in hundreds of neighborhoods across the country, my aim is to analyze the way the structural poor and recently impoverished middle class transformed themselves into citizens and have contributed to the emergence of a new form of life: plebeian democracy. In dialogue with Partha Chatterjee's work on 'governmentalized populations' in the global south, my discussion highlights some of the particular and distinctive features of plebeianism in contemporary Buenos Aires and its implications for the future of democratic life across the global south.

Coarse typological studies on urban program and density defined by various urban energy conversion technologies in Singapore. Zhongming Shi1,2, Shanshan Hsieh1,2,3, Bhargava Krishna Sreepathi1,2, Jimeno A. Fonseca1,2, François Maréchal1,3, Arno Schlueter1,2 1 Future Cities Laboratory, Singapore-ETH Centre, 1 Create Way, CREATE Tower, 138602 Singapore 2 Architecture and Building Systems, Institute of Technology in Architecture, ETH Zurich, John-von-Neumann-Weg 9, CH-8093 Zurich, Switzerland 3 Industrial Process and Energy Systems Engineering Group, Ecole Polytechnique Federale de Lausanne, Lausanne 1015, Switzerland E-mail: shi@arch.ethz.ch, nils.schueler@epfl.ch, hsieh@arch.ethz.ch, sebastien.cajot@epfl.ch, fonseca@arch.ethz.ch, francois.marechal@epfl.ch, schlueter@arch.ethz.ch Keywords: Urban typology, urban form, energy technology, urban program, density Conference topics and scale: Efficient use of resources in sustainable cities Cities consume about three quarters of global primary energy. Compared to the beginning of the Twentieth Century, the urban area is expected to triple by 2030. The future urban energy performance is substantially influenced by how the urban area is planned, designed, and built. New energy technologies have enabled new possibilities of the urban form. For example, a district cooling system can free the building rooftops for more architectural design options, like an infinity pool or a sky garden. Vice versa, to maximize the energy performance, some new energy technologies enforce some specific requirements on the urban forms, like the urban form and density. We apply a Mixed Integer Linear Programming (MILP) formulation to identify the optimal allocation of energy demand density and energy systems (e.g. district cooling network) subject to resource availability and energy (or environmental) performance targets (e.g. renewable share). The optimized energy demand density can be translated into urban program combinations and density ranges and gradients. To build the model, we survey the prevailing energy conversion technologies and their costs. Based on the local standards of Singapore, we derive the energy profiles and demand densities of buildings with different programs. We adopt a real case study in Singapore to test the target energy technologies. Adjacent to the existing central business district, the site, currently a container terminal, has an area around 1,000 hectares. Upon the relocation of the terminal in 10 years, the energy technologies, the density, and the program of the site have a variety of possibilities. This paper builds a series of coarse urban typologies in terms of urban program and density when adopting different urban energy conversion technologies in Singapore. Furthermore, the general density and the density gradient may vary when the size of these energy infrastructures alters. In an integrated urban design process involving energy considerations, the urban designer can refer these urban typologies for rules on the general density, the density gradient, and the urban program combination based on the selected energy technologies. On the other way, these urban typologies can also help on the selection of energy technologies to accommodate the target urban density and program. References (100 words) Ratti, C., Baker, N., and Steemers, K. (2005). Energy consumption and urban texture. Energy Build. 37, 762–776. Salat, S. (2009). Energy loads, CO2 emissions and building stocks: morphologies, typologies, energy systems and behaviour. Build. Res. Inf. 37, 598–609. Seto, K.C., Güneralp, B., and Hutyra, L.R. (2012). Global forecasts of urban expansion to 2030 and direct impacts on biodiversity and carbon pools. Proc. Natl. Acad. Sci. U. S. A. 109, 16083–16088. UN-Habitat (2012). Energy. [Online]. Available: http://unhabitat.org/urban-themes/energy. [Accessed:08-Nov-2016].

A patient with acquired variant von Willebrand's disease was given an infusion of 2000 units of high purity porcine factor VIII (Hyate). Quantitative factor VIII parameters were assessed following infusion and human factor VIII multimers were analysed by radioimmunoelectrophoresis and autoradiography. We have previously described the patient to have acquired von Willebrand's disease due to a circulating inhibitor to the factor VIII complex (B. J. Haematol-, 54,233,1983). Prior to infusion plasma from the patient contained factor VIIIC, RRCo, and vWFAg at less than 10 u/dl- Plasma factor VIII multimers showed an abnormal pattern with no high molecular weight bands present despite a normal triplet structure in the low molecular weight forms. After the infusion of porcine factor VIII concentrate a large increase in the levels of plasma VIIIC was detected with a disappearance half-life of 3.5 hours. A specific non-crossreacting immunoradiometric assay (IRMA) showed that plasma levels of porcine vWFAg did not rise significantly after the infusion. Despite this, human vWFAg levels were notably elevated at 1 hour (40 u/dl by Laurell) and 2 hours (30 u/dl by IRMA) post infusion. Similarly, ristocetin induced platelet aggregation and plasma RRCo levels showed significant elevations , 2 hours after the infusion. Factor VIII multimers assessed on plasma samples taken over a similar time period revealed the transient appearance of a normal compliment of human factor VIII multimeric forms 2 hours after the infusion of porcine factor VIII concentrate. This study indicates that the abnormal pattern of factor VIII multimeric bands present in inhibitor-related variant acquired von Willebrand's disease can be transiently normalised by infused porcine factor VIII concentrate. Whether this represents antibody displacement or de novo synthesis is yet to be determined.

Plasminogen activators (PA) are thought to play a role in the invasive and metastatic properties of many types of cancer cells. Though, discrepancies in correlations between fibrinolytic activity and metastatic potential of malignant cells have been described.In this study, we evaluated both tissue type (tPA) and urokinase type (UK) cellular PA activities in different mononuclear cell types : normal T and B human peripheral lymphocytes, B cells from patients with chronic lymphocytic leukemia (CLL), human blood monocytes, alveolar macrophages, U 937, RAJI and JM cell 1ines.Mononuclear cells were isolated by Ficoll-hypaque gradients and monocytes by plastic adhesion. T and B cells were separated by a rosetting technique using sheep red blood cells. Cellular extracts were prepared by 0.5 % Triton X 100 buffer treatment followed by sonication and centrifugation 10 ' at 2000 g. PA assays were performed on the supernatants.UK-type PA was evaluated by a liquid-phase assay in presence of human plasminogen (Kabi) and chromogenic substrate S 2251 (Kabi).tPA was determinated using a solid-phase fibrin activity assay which involves an affinity separation step and thus allows selective detection of tPA.In both cases, results were reported in international units by reference to standard curves of UK (Choay) or tPA (Kabi).In all cell types tested, PA detected was essentially urokinase-type. Highest PA activity was found in U 937 cells (0.7 IU/5×l06 cells). In normal blood lymphocytes, mean PA activity was 0.08 IU/5×l06 cells. Examination of lymphocytes from patients with CLL revealed a marked decrease in UK activity as compared to normals (< 0.01 IU/5×106 cells in more than 50 % cases).The function of PA in normal lymphocyte physiology and the potential pathogenic role of diminished PA in CLL lymphocytes remains to be investigated.

The answer of why Russia is not affected from today’s global crisis, considerably, is crucial. Since 1990, Russia has been liberalizing its markets rapidly, has decreased implementations which are deterrent for open market significantly until these days. By 2000’s Russia, has entered to a new term in which economic profit and instrument depending on energy sources are commented as basic priorities and instruments at foreign policy. In this study Russia’s free market applications with this new era are dealt with and results of these applications are found out with the framework of 2008 global crisis.

In spatial, social and cultural pluralism, the questions of human intentionality and socio-spatial emergence remain central to social theory (Portugali 2000, p.142). The correlation between individual preferences, values and intentions, and actual behaviour and actions, is subject to Portugali’s theory of self-organisation (2000). Compared to Gidden’s structuralism, which focuses on society and groups, the point of departure for Portugali (2000) are individuals and their personal choices. The key feature in how complex systems `self-organise', is that they `interpret', the information that comes from the environment (Portugali 2006). The current study explores the urban environment formerly inhabited, and largely constructed, by Jews in two central Polish districts: Mazovia and Lodz, before the tragedy of the Holocaust. While the Jewish presence lasted from the 11th century until the outbreak of World War II, the most intensive development took place in the 19th century, together with the civilisation changes introduced by industrialisation. Embracing the everyday habits of Jewish citizens endows the neighbourhood structures they once inhabited with long gone meanings, the information layer which once helped organise everyday life. The main thesis reveals that Jewish communities in pre-war Poland represented an example of a self-organising society, one which could be considered a prototype of contemporary postmodern cultural complexity. The mapping of this complexity at the scale of a neighbourhood is a challenge, a method for which is addressed in the current paper. The above considerations are in line with the empirical studies of the relations between Jews and Poles, especially in large cities, where more complex socio-cultural processes could have occurred. References: Eco, U. (1997) ‘Function and Sign: The Semiotics of Architecture’, in Leich, N. (ed.) Rethinking Architecture: A reader in cultural theory (Routledge Taylor & Francis Group, London) 182–202. Hillier, B. and Hanson, J. (2003) The Social Logic of Space (Cambridge University Press, Cambridge). Marshall, S. (2009) Cities, Design and Evolution (Routledge, Abingdon, New York). Portugali, J. (2000) Self-Organization and the City, (Springer-Verlag, Berlin Heidelberg). Portugali, J. (2006) ‘Complexity theory as a link between space and place’, Environment and Planning A 38(4) 647–664.

Abstract Granular composite formulations involving metal/metal [1,2] (intermetallic) reactions have been investigated for a number of applications. Interfaces between metallic particles have been attributed particular importance due to their ability to form localized hotspots, where the local temperature of the granular composite may significantly exceed the global temperature, leading to a localized reaction initiation that may initiate a global reaction.3 Understanding of the response of metal/metal granular composites to mechanical loading can be greatly facilitated by mesoscale modeling in which the underlying composite structure of the components is clearly resolved. For the Al/Ni composite discussed in this study, this involves explicitly resolving Al and Ni particles and intermetallic (Al/Al, Ni/Ni and Al/Ni) interfaces. In this work we utilize an idealized but realistic model for an Al/Ni composite using EOS, constitutive and interfacial models informed by molecular dynamics (MD) simulations. The Al/Ni microstructures are subjected to uniaxial compressive loading up to 30 GPa, shock loading up to 70 GPa (2000 m/s) and impact loading at 2000 m/s, and the mechanical and thermal response of the composite are analyzed.

Abstract Human’s motion and its mechanisms had become interesting in the last years, where the medecine’s field search for rehabilitation methods for handicapped persons. Other fields, like sport sciences, professional or military world, search to distinguish profiles and ways to train them with specific purposes. Besides, recent findings in neuroscience try to describe these mechanisms from an organic point of view. Until now, different researchs had given a model about control motor that describes how the union between the senses’s information allows adaptable movements. One of this sense is the proprioception, the sense which has a quite big factor in the orientation and position of the body, its members and joints. For this reason, research for new strategies to explore proprioception and improve the theories of human motion could be done by three different vias. At first, the sense is analysed in a case-study where three groups of persons are compared in a controlled enviroment with three experimental tasks. The subjects belong to each group by the kind of sport they do: sedentary, normal sportsmen (e.g. athletics, swimming) and martial sportmen (e.g. karate, judo). They are compared thinking about the following hypothesis: “Martial Sportmen have a better proprioception than of the other groups’s subjects: It could be due to the type of exercises they do in their sports as empirically, a contact sportsman shows significantly superior motor skills to the members of the other two groups. The second via are records from encephalogram (EEG) while the experimental tasks are doing. These records are analised a posteriori with a set of processing algorithms to extract characteristics about brain’s activity of the proprioception and motion control. Finally , the study tries to integrate graphic tools to make easy to understand final scientific results which allow us to explore the brain activity of the subjects through easy interfaces (e.g. space-time events, activity intensity, connectivity, specific neural netwoks or anormal activity). In the future, this application could be a complement to assist doctors, researchers, sports center specialists and anyone who must improve the health and movements of handicapped persons. Keywords: proprioception, EEG, assesment, rehabilitation.References: Röijezon, U., Clark, N.C., Treleaven, J. (2015). Proprioception in musculoskeletal rehabilitation. Part 1: Basic science and principles of assessment and clinical interventions. ManualTher.10.1016/j.math.2015.01.008. Röijezon, U., Clark, N.C., Treleaven, J. (2015). Proprioception in musculoskeletal rehabilitation. Part 2: Clinical assessment and intervention. Manual Ther.10.1016/j.math.2015.01.009. Roren, A., Mayoux-Benhamou, M.A., Fayad, F., Poiraudeau, S., Lantz, D., Revel, M. (2008). Comparison of visual and ultrasound based techniques to measure head repositioning in healthy and neck-pain subjects. Manual Ther. 10.1016/j.math.2008.03.002. Hillier, S., Immink, M., Thewlis, D. (2015). Assessing Proprioception: A Systematic Review of Possibilities. Neurorehab. Neural Repair. 29(10) 933–949. Hooper, T.L., James, C.R., Brismée, J.M., Rogers, T.J., Gilbert, K.K., Browne, K.L, Sizer, P.S. (2016). Dynamic Balance as Measured by the Y-Balance Test Is Reduced in Individuals with low Back Pain: A Cross-Sectional Comparative Study. Phys. Ther. Sport,10.1016/j.ptsp.2016.04.006. Zemková, G., Stefániková, G., Muyor, J.M. (2016). Load release balance test under unstable conditions effectivelydiscriminates between physically active and sedentary young adults. Glave, A.P., Didier, J.J., Weatherwax, J., Browning, S.J., Fiaud, Vanessa. (2014). Testing Postural Stability: Are the Star Excursion Balance Test and Biodex Balance System Limits of Stability Tests Consistent? Gait Posture. 43(2016) 225-227. Han, Jian., Waddington, G., Adams, R., Anson, J., Liu, Y. (2014). Assessing proprioception: A critical review of methods. J. Sport Health Sci.10.1016/j.jshs.2014.10.004. Hosp, S., Bottoni, G., Heinrich, D., Kofler, P., Hasler, M., Nachbauer, W. (2014). A pilot study of the effect of Kinesiology tape on knee proprioception after physical activity in healthy women. J. Sci. Med. Sport. 18 (2015) 709-713. Mima, T., Terada, K., Ikeda, A., Fukuyama, H., Takigawa, T., Kimura, J., Shibasaki, H. (1996). Afferent mechanism of cortical myoclonus studied by proprioception-related SEPs. Clin. Neurophysiol. 104 (1997) 51-59. Myers, J.B., Lephart, S.M. (2000). The Role of the Sensorimotor System in the Athletic Shoulder. J. Athl.Training.35 (3) 351-363. Rossi, S., della Volpe, R., Ginannesch, F., Ulivelli, M., Bartalini, S., Spidalieri, R., Rossi, A. (2003). Early somatosensory processing during tonic muscle pain in humans: relation to loss of proprioception and motor 'defensive' strategies. Clin. Neurophysiol. 10.1016/S1388-2457(03)00073-7. Chaudhary, U., Birbaumer, N., Curado, M.R. (2014). Brain-Machine Interface (BMI) in paralysis. Ann. Phys. Rehabil. Med.10.1016/j.rehab.2014.11.002. Delorme, A., Makeig, S. (2003). EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. J. Neurosci. Meth.10.1016/j.jneumeth.2003.10.009. Morup, M., Hansen, L.K., Arnfred, S.M. (2006). ERPWAVELAB: A toolbox for multi-channel analysis of time-frequency transformed event related potentials. J. Neurosci. Meth.10.1016/j.jneumeth.2003.11.008. Kaminski, M., Blinowska, K., Szelenberger, W. (1996). Topographic analysis of coherence and propagation of EEG activity during sleep and wakefulness. Clin. 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Koessler, L., Maillard, L., Benhadid, A., Vignal, J.P., Felblinger, J., Vespignani, H., Braun, M. (2009). Automated cortical projection of EEG: Anatomical correlation via the international 10-10 system. Neuroimage. 10.1016/j.neuroimage.2009.02.006. Jurcak, V., Tsuzuki, Daisuke., Dan, I. (2007). 10/20, 10/10, and 10/5 systems revisited: Their validity as relativehead-surface-based positioning systems. Neuroimage. 10.1016/j.neuroimage.2006.09.024. Chuang, L.Y., Huang, C.J., Hung, T.M. (2013). The differences in frontal midline theta power between successful and unsuccessful basketball free throws of elite basketball players. Int. J. Psychophysiology.10.1016/j.ijpsycho.2013.10.002. Wang, C.H., Tsai, C.L., Tu, K.C., Muggleton, N.G., Juan, C.H., Liang, W.K. (2014). Modulation of brain oscillations during fundamental visuo-spatialprocessing: A comparison between female collegiate badmintonplayers and sedentary controls. Psychol. Sport Exerc. 10.1016/j.psychsport.2014.10.003. 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Since the beginning of 1980's advancements in studies on competitiveness and clustering in global scale have also affected the manufacturing sector in Turkey at the beginning of 2000's. In several debates, it has been strongly emphasized that measurement of both competitiveness and clustering in regional level is a necessity for analyze and implementation processes. This study aims to investigate clustering tendency of footwear manufacturers and to analyze competition power of firms in Konya province in Turkey. For this purpose, footwear industry in the province is analyzed by Porter’s Diamond Model. In addition to Porter’s Model, effect of government factor was included in the analysis. Furthermore, a SWOT analyze was performed through workshops with manufacturers. In regard to competitiveness analysis of footwear industry in Konya, it is shown that the industry has an intermediate competition power. According to analysis, physical conditions of the industry is favorable in context of factor requirements, while lack of human resources is seen as a serious problem in labor-intensive sectors. Also, knowledge spillovers depending upon density and availability in conventional relationships are regarded as an important advantage.

Contemporary processes of urbanization have outpaced the traditional notion of city. Connectivity has become a distinctive characteristic of urban spaces, so that networked cities don’t rely anymore on continuous urbanized areas, but on connections that rarely leave a direct spatial footprint. The new spatial structure of urban areas include greater inter-penetration of built-up and open spaces, and the emergence of urban enclaves, which can be spatially isolated despite being functionally connected to a city. In order to study these enclaves and their impact on urban form, a sample of 47 Spanish functional urban areas was examined, ranging from 36,000 to 6.0 million inhabitants. Land use polygons provided by SIOSE were grouped into three main categories (residential, non-residential and urban infrastructure) and cross-matched with functional urban areas defined by AUDES (an iterative method than combines morphological and functional criteria) in order to calculate compactness proximity index, gross and net density. Factors that influence urban compactness were identified: most northern and some coastal urban areas display a low compactness which can be attributed to orographic conditions; bigger cities tend to display high compactness, but smaller ones display a great diversity of values, from the highest to the lowest. A further analysis of small and intermediate cities helped to identify two complementary mechanisms of urban growth, spatial expansion of core areas and functional integration of peripheral nuclei, whose ocurrence in different proportions can explain the variation of compactness in the studied sample. References Angel, S.; Parent, J.; Civco, D. L. (2012) ‘The fragmentation of urban landscapes: global evidence of a key attribute of the spatial structure of cities, 1990-2000’, Environment and Urbanization, 24 (1), 249-283. Ascher, F. (1995) Métapolis ou l'avenir des villes. (Paris: Éditions Odile Jacob.) Dupuy, G. (1991) L'urbanisme des réseaux, théories et méthodes. (Paris: Armand Colin.) Harvey, D. (1996) ‘Cities or urbanization?’, City 1 (2): 38-61. IGN (2007) SIOSE, Sistema de Información sobre Ocupación del Suelo (http://www.siose.es/), accessed 31 Jan. 2017. Ruiz, F. (2011) AUDES, Áreas Urbanas de España (http://alarcos.esi.uclm.es/per/fruiz/audes/), accessed 31 Jan. 2017.