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Relevant bibliographies by topics / Glomerular filtration analysis

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Academic literature on the topic 'Glomerular filtration analysis'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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Journal articles on the topic "Glomerular filtration analysis"

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Riegel, JA. "Analysis of fluid dynamics in perfused glomeruli of the hagfish eptatretus stouti (Lockington)." Journal of Experimental Biology 201, no. 22 (1998): 3097–104. http://dx.doi.org/10.1242/jeb.201.22.3097.

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The capillary tuft of glomeruli of the hagfish mesonephros contains both 'low'-pressure and 'high'-pressure glomerular vessels (LPGVs and HPGVs). The existence of the HPGV raised the possibility that pressure filtration could occur in the hagfish kidney when the blood pressure was sufficiently high. Therefore, measurements of glomerular capillary pressure were made in HPGVs and LPGVs whilst single glomeruli were perfused with hagfish Ringer's solution that contained the colloid Ficoll 70. Calculations of the effective colloid osmotic pressure in perfused capillaries were made; these showed tha

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Arendshorst, W. J., and C. W. Gottschalk. "Glomerular ultrafiltration dynamics: historical perspective." American Journal of Physiology-Renal Physiology 248, no. 2 (1985): F163—F174. http://dx.doi.org/10.1152/ajprenal.1985.248.2.f163.

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Our knowledge of the structure and function of the renal glomerulus is reviewed in a historical context. The glomerular corpuscles were first described by Malpighi in 1666. Subsequent injection studies led to conflicting claims concerning a glomerular-tubular connection. This connection was accepted only after the convincing demonstration of the anatomical relationship essentially as we now know it by Bowman in 1842. Ludwig was the first to propose that the mechanism of separation of fluid in the glomeruli was by ultrafiltration. Estimates of the ultrafiltration forces in mammals led to confli

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Dong, Jianghu J., Liangliang Wang, Jagbir Gill, and Jiguo Cao. "Functional principal component analysis of glomerular filtration rate curves after kidney transplant." Statistical Methods in Medical Research 27, no. 12 (2017): 3785–96. http://dx.doi.org/10.1177/0962280217712088.

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This article is motivated by some longitudinal clinical data of kidney transplant recipients, where kidney function progression is recorded as the estimated glomerular filtration rates at multiple time points post kidney transplantation. We propose to use the functional principal component analysis method to explore the major source of variations of glomerular filtration rate curves. We find that the estimated functional principal component scores can be used to cluster glomerular filtration rate curves. Ordering functional principal component scores can detect abnormal glomerular filtration r

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Squarer, A., K. V. Lemley, S. Ambalavanan, et al. "Mechanisms of progressive glomerular injury in membranous nephropathy." Journal of the American Society of Nephrology 9, no. 8 (1998): 1389–98. http://dx.doi.org/10.1681/asn.v981389.

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Glomerular function and structure were serially evaluated in 15 patients with membranous nephropathy who exhibited relapsing nephrosis and chronic depression of GFR. GFR declined from 56+/-8 (mean+/-SEM) at onset to 31+/-4 ml/min per 1.73 m2 after a 2- to 5-yr period of observation (P < 0.05). An analysis of filtration dynamics suggested persistent elevation of net ultrafiltration pressure. To examine a possible role for declining intrinsic glomerular filtration capacity as the basis for the observed hypofiltration, glomeruli in the baseline and a repeat biopsy (performed after a median of

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Drummond, I. A., A. Majumdar, H. Hentschel, et al. "Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function." Development 125, no. 23 (1998): 4655–67. http://dx.doi.org/10.1242/dev.125.23.4655.

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The zebrafish pronephric kidney provides a simplified model of nephron development and epithelial cell differentiation which is amenable to genetic analysis. The pronephros consists of two nephrons with fused glomeruli and paired pronephric tubules and ducts. Nephron formation occurs after the differentiation of the pronephric duct with both the glomeruli and tubules being derived from a nephron primordium. Fluorescent dextran injection experiments demonstrate that vascularization of the zebrafish pronephros and the onset of glomerular filtration occurs between 40 and 48 hpf. We isolated fifte

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Anderson, W. P., D. Alcorn, A. I. Gilchrist, J. M. Whiting, and G. B. Ryan. "Glomerular actions of ANG II during reduction of renal artery pressure: a morphometric analysis." American Journal of Physiology-Renal Physiology 256, no. 6 (1989): F1021—F1026. http://dx.doi.org/10.1152/ajprenal.1989.256.6.f1021.

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The glomeruli of kidneys subjected to reduced perfusion pressure were examined morphometrically. The left renal artery was narrowed for 30 min in anesthetized dogs with (n = 6) or without (n = 7) converting-enzyme inhibition (captopril). The kidneys were then rapidly fixed by glutaraldehyde perfusion at high flow rate. In a comparison of glomeruli of kidneys subjected to pressure reduction in captopril-treated and untreated dogs, there was significantly greater mesangial contraction in the latter, but morphometric analysis revealed no significant differences in the glomerular surface area avai

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Scharschmidt, L. A., J. G. Douglas, and M. J. Dunn. "Angiotensin II and eicosanoids in the control of glomerular size in the rat and human." American Journal of Physiology-Renal Physiology 250, no. 2 (1986): F348—F356. http://dx.doi.org/10.1152/ajprenal.1986.250.2.f348.

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We examined the possibility that glomerular prostaglandin E2 (PGE2) regulates the action of angiotensin II (ANG II) on mesangial contraction and filtration surface area. Using isolated rat glomeruli we indirectly assessed mesangial contraction and filtration surface area through measurements of glomerular planar surface area (GPSA) by image-analysis microscopy. ANG II reduced GPSA by approximately 20% in human and rat glomeruli, with threshold concentrations of 1 X 10(-13) M and maximum effect at 5 X 10(-11) M ANG II. Inhibition of glomerular PG synthesis with indomethacin or meclofenamate pot

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Uchio-Yamada, Kozue, Keiko Yasuda, Yoko Monobe, Ken-ichi Akagi, Osamu Suzuki, and Noboru Manabe. "Tensin2 is important for podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier." American Journal of Physiology-Renal Physiology 318, no. 6 (2020): F1520—F1530. http://dx.doi.org/10.1152/ajprenal.00055.2020.

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Tensin2 (Tns2), an integrin-linked protein, is enriched in podocytes within the glomerulus. Previous studies have revealed that Tns2-deficient mice exhibit defects of the glomerular basement membrane (GBM) soon after birth in a strain-dependent manner. However, the mechanisms for the onset of defects caused by Tns2 deficiency remains unidentified. Here, we aimed to determine the role of Tns2 using newborn Tns2-deficient mice and murine primary podocytes. Ultrastructural analysis revealed that developing glomeruli during postnatal nephrogenesis exhibited abnormal GBM processing due to ectopic l

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Myers, B. D., and L. Newton. "Cyclosporine-induced chronic nephropathy: an obliterative microvascular renal injury." Journal of the American Society of Nephrology 2, no. 2 (1991): S45. http://dx.doi.org/10.1681/asn.v22s45.

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Physiologic and morphologic techniques have been used to study kidneys of 200 cardiac transplant recipients treated with either low- or high-dose cyclosporine. After 12 months, both low- (4.6 +/- 0.4) and high-dose cyclosporine (6.3 +/- 0.3 mg/kg/24 h; P less than 0.01) were associated with depression of glomerular filtration rate below values in a third group of 100 recipients never exposed to cyclosporine by 40 to 47%. Determination of renovascular pressures and flows as well as analysis of transglomerular sieving of dextrans revealed renal vascular resistance in cyclosporine-treated recipie

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Hladunewich, M. A., R. A. Lafayette, G. C. Derby, et al. "The dynamics of glomerular filtration in the puerperium." American Journal of Physiology-Renal Physiology 286, no. 3 (2004): F496—F503. http://dx.doi.org/10.1152/ajprenal.00194.2003.

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We evaluated the glomerular filtration rate (GFR) during the second postpartum week in 22 healthy women who had completed an uncomplicated pregnancy. We used physiological techniques to measure GFR, renal plasma flow, and oncotic pressure and computed a value for the two-kidney ultrafiltration coefficient ( Kf). We compared these findings with those in pregnant women previously studied on the first postpartum day as well as nongravid women of reproductive age. Healthy female transplant donors of reproductive age permitted the morphometric analysis of glomeruli and computation of the single-nep

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Dissertations / Theses on the topic "Glomerular filtration analysis"

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Walton, H. A. "The effect of structural modifications on the permeation properties of renal basement membrane." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382711.

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Roberts, Mark. "Assessment of glomerular dynamics in human pregnancy using theoretical analysis and dextran sieving coefficients." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336811.

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Akbari, Ayub. "Change in Referral Patterns to Nephrologists after Estimated Glomerular Filtration Rate (eGFR) Reporting: An interrupted time series analysis." Thesis, University of Ottawa (Canada), 2011. http://hdl.handle.net/10393/28785.

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Objectives: To update a Cochrane review of interventions to improve outpatient referral and to assess changes in referrals to nephrologists after initiating automatic estimated glomerular filtration rate (eGFR) reporting. Methods: Systematic review using standardized Cochrane methods. Before and after study with interrupted time series analysis using data from retrospective chart review on referrals from family medicine to nephrology. Results: Review added one new study and removed one for total of 17 studies. Referrals improved with education and structured referral sheets. Of 2766 eligible r

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Coelho, Fernanda Oliveira. "Efeitos renais da exposição crônica a nicotina em camundongos com deficiência de Klotho." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-09112015-124235/.

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A nicotina é o principal componente do tabaco e dos cigarros eletrônicos. A exposição crônica a nicotina, em quantidades semelhantes às atingidas pelo tabagismo humano, é responsável por piora da lesão renal aguda e da doença renal crônica. O gene klotho, predominantemente expresso no rim, foi descoberto após uma mutação insercional, com o surgimento de um fenótipo semelhante ao envelhecimento humano nos camundongos homozigotos para esse transgene. A proteína Klotho transmembrana tem ação de co-receptor do fator de crescimento fibroblástico 23 (FGF-23) e sua forma secretada atua em diversas vi

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Steinbruckner-Gaildraud, Ingrid. "Un nouveau marqueur d'évaluation de la filtration glomérulaire : la cystatine C sérique." Bordeaux 2, 2000. http://www.theses.fr/2000BOR2P040.

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Books on the topic "Glomerular filtration analysis"

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Virginia. Department of Medical Assistance Services. Estimated glomerular filtration rate reporting among clinical laboratory providers: Report of the Virginia Department of Medical Assistance Services to the Governor and the General Assembly of Virginia. Commonwealth of Virginia, 2007.

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Hall, Andrew, and Shamima Rahman. Mitochondrial diseases and the kidney. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0340.

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Mitochondrial disease can affect any organ in the body including the kidney. As increasing numbers of patients with mitochondrial disease are either surviving beyond childhood or being diagnosed in adulthood, it is important for all nephrologists to have some understanding of the common renal complications that can occur in these individuals. Mitochondrial proteins are encoded by either mitochondrial or nuclear DNA (mtDNA and nDNA, respectively); therefore, disease causing mutations may be inherited maternally (mtDNA) or autosomally (nDNA), or can arise spontaneously. The commonest renal pheno

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Goligorsky, Michael S., Julien Maizel, Radovan Vasko, May M. Rabadi, and Brian B. Ratliff. Pathophysiology of acute kidney injury. Edited by Norbert Lameire. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0221.

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In the intricate maze of proposed mechanisms, modifiers, modulators, and sensitizers for acute kidney injury (AKI) and diverse causes inducing it, this chapter focuses on several common and undisputable strands which do exist.Structurally, the loss of the brush border, desquamation of tubular epithelial cells, and obstruction of the tubular lumen are commonly observed, albeit to various degrees. These morphologic hallmarks of AKI are accompanied by functional defects, most consistently reflected in the decreased glomerular filtration rate and variable degree of reduction in renal blood flow, a

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Book chapters on the topic "Glomerular filtration analysis"

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Pedersen, Michael, Pietro Irrera, Walter Dastrù, et al. "Dynamic Contrast Enhancement (DCE) MRI–Derived Renal Perfusion and Filtration: Basic Concepts." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-0978-1_12.

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AbstractDynamic contrast-enhanced (DCE) MRI monitors the transit of contrast agents, typically gadolinium chelates, through the intrarenal regions, the renal cortex, the medulla, and the collecting system. In this way, DCE-MRI reveals the renal uptake and excretion of the contrast agent. An optimal DCE-MRI acquisition protocol involves finding a good compromise between whole-kidney coverage (i.e., 3D imaging), spatial and temporal resolution, and contrast resolution. By analyzing the enhancement of the renal tissues as a function of time, one can determine indirect measures of clinically important single-kidney parameters as the renal blood flow, glomerular filtration rate, and intrarenal blood volumes. Gadolinium-containing contrast agents may be nephrotoxic in patients suffering from severe renal dysfunction, but otherwise DCE-MRI is clearly useful for diagnosis of renal functions and for assessing treatment response and posttransplant rejection.Here we introduce the concept of renal DCE-MRI, describe the existing methods, and provide an overview of preclinical DCE-MRI applications to illustrate the utility of this technique to measure renal perfusion and glomerular filtration rate in animal models.This publication is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction is complemented by two separate publications describing the experimental procedure and data analysis.

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Irrera, Pietro, Lorena Consolino, Walter Dastrù, Michael Pedersen, Frank G. Zöllner, and Dario Livio Longo. "Dynamic Contrast Enhanced (DCE) MRI-Derived Renal Perfusion and Filtration: Experimental Protocol." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-0978-1_25.

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AbstractDynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can provide a noninvasive way for assessing renal functional information following the administration of a small molecular weight gadolinium-based contrast agent. This method may be useful for investigating renal perfusion and glomerular filtration rates of rodents in vivo under various experimental (patho)physiological conditions. Here we describe a step-by-step protocol for DCE-MRI studies in small animals providing practical notes on acquisition parameters, sequences, T1 mapping approaches and procedures.This chapters is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This experimental protocol chapter is complemented by two separate chapters describing the basic concept and data analysis.

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Ku, Min-Chi, María A. Fernández-Seara, Frank Kober, and Thoralf Niendorf. "Noninvasive Renal Perfusion Measurement Using Arterial Spin Labeling (ASL) MRI: Basic Concept." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-0978-1_13.

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AbstractThe kidney is a complex organ involved in the excretion of metabolic products as well as the regulation of body fluids, osmolarity, and homeostatic status. These functions are influenced in large part by alterations in the regional distribution of blood flow between the renal cortex and medulla. Renal perfusion is therefore a key determinant of glomerular filtration. Therefore the quantification of regional renal perfusion could provide important insights into renal function and renal (patho)physiology. Arterial spin labeling (ASL) based perfusion MRI techniques, can offer a noninvasive and reproducible way of measuring renal perfusion in animal models. This chapter addresses the basic concept of ASL-MRI.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by two separate chapters describing the experimental procedure and data analysis.

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Longo, Dario Livio, Pietro Irrera, Lorena Consolino, Phillip Zhe Sun, and Michael T. McMahon. "Renal pH Imaging Using Chemical Exchange Saturation Transfer (CEST) MRI: Basic Concept." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-0978-1_14.

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AbstractMagnetic Resonance Imaging (MRI) has been actively explored in the last several decades for assessing renal function by providing several physiological information, including glomerular filtration rate, renal plasma flow, tissue oxygenation and water diffusion. Within MRI, the developing field of chemical exchange saturation transfer (CEST) has potential to provide further functional information for diagnosing kidney diseases. Both endogenous produced molecules as well as exogenously administered CEST agents have been exploited for providing functional information related to kidney diseases in preclinical studies. In particular, CEST MRI has been exploited for assessing the acid-base homeostasis in the kidney and for monitoring pH changes in several disease models. This review summarizes several CEST MRI procedures for assessing kidney functionality and pH, for monitoring renal pH changes in different kidney injury models and for evaluating renal allograft rejection.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by two separate chapters describing the experimental procedure and data analysis.

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Jerome, Neil Peter, Anna Caroli, and Alexandra Ljimani. "Renal Diffusion-Weighted Imaging (DWI) for Apparent Diffusion Coefficient (ADC), Intravoxel Incoherent Motion (IVIM), and Diffusion Tensor Imaging (DTI): Basic Concepts." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-0978-1_11.

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AbstractThe specialized function of the kidney is reflected in its unique structure, characterized by juxtaposition of disorganized and ordered elements, including renal glomerula, capillaries, and tubules. The key role of the kidney in blood filtration, and changes in filtration rate and blood flow associated with pathological conditions, make it possible to investigate kidney function using the motion of water molecules in renal tissue. Diffusion-weighted imaging (DWI) is a versatile modality that sensitizes observable signal to water motion, and can inform on the complexity of the tissue microstructure. Several DWI acquisition strategies are available, as are different analysis strategies, and models that attempt to capture not only simple diffusion effects, but also perfusion, compartmentalization, and anisotropy. This chapter introduces the basic concepts of DWI alongside common acquisition schemes and models, and gives an overview of specific DWI applications for animal models of renal disease.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by two separate chapters describing the experimental procedure and data analysis.

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Srivastava, Devesh Kumar, and Pradeep Kumar Tiwari. "Chronic Kidney Disease Prediction Using Data Mining Algorithms." In Handbook of Research on Disease Prediction Through Data Analytics and Machine Learning. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-2742-9.ch006.

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In today's contemporary world, it is important to know about the odds of having a disease because of changing living standards of the population overall in the continent. The disease on which the authors are working is chronic kidney disease. Once the person gets chronic kidney disease (CKD), his working capability decreases along with other adverse effects. It is possible to get rid of diseases like CKD with new methodologies that will help us to predict the stage of kidney disease at an early stage. Under big data analytics, data may be structured, unstructured, quasi- or semi-structured. The CKD detected and predicted by applying classification models: support vector machine (SVM), K-nearest neighbor (KNN), and logistic regression algorithm. It helps in predicting the likelihood of occurrence of disease on various different features. The two algorithms KNN and SVM are compared to find the algorithm that gives better accuracy. Further regression technique has been used to detect the disease based on, which the stages are classified by using GFR (glomerular filtration rate) formula.

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Conference papers on the topic "Glomerular filtration analysis"

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De Senneville, B. Denis, P. Desbarats, M. Ries, C. T. W. Moonen, and N. Grenier. "Automatic Region Tracking for MR Glomerular Filtration Rate Analysis." In 2006 International Conference on Image Processing. IEEE, 2006. http://dx.doi.org/10.1109/icip.2006.312999.

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Rafeeque, Ameena, and Mohammed Fasihul Alam. "The effect of Renin Angiotensin System Blockers versus Calcium Channel Blockers on Progression towards Hypertensive Chronic Kidney Disease: A comprehensive systematic review based on Randomized Controlled Trials." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0162.

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Background: Decline in estimated Glomerular filtration rate (eGFR) is associated with further progression of chronic kidney disease. Evidence suggests that Renin Angiotensin System blockers (RAS), which can be angiotensin-receptor blockers (ARBs) or Angiotensin converting enzymes Inhibitors (ACEIs), have reno- protective effect, but results are variable. Similarly, effects of Calcium channel blockers (CCBs) are shown to have a role in protecting renal function but differ across studies. Hence, the relative effect of ARBs or ACEIs as well as CCBs, and their administration as monotherapy, remain

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