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Journal articles on the topic 'Glomerular filtration analysis'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

Riegel, JA. "Analysis of fluid dynamics in perfused glomeruli of the hagfish eptatretus stouti (Lockington)." Journal of Experimental Biology 201, no. 22 (1998): 3097–104. http://dx.doi.org/10.1242/jeb.201.22.3097.

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The capillary tuft of glomeruli of the hagfish mesonephros contains both 'low'-pressure and 'high'-pressure glomerular vessels (LPGVs and HPGVs). The existence of the HPGV raised the possibility that pressure filtration could occur in the hagfish kidney when the blood pressure was sufficiently high. Therefore, measurements of glomerular capillary pressure were made in HPGVs and LPGVs whilst single glomeruli were perfused with hagfish Ringer's solution that contained the colloid Ficoll 70. Calculations of the effective colloid osmotic pressure in perfused capillaries were made; these showed tha

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2

Arendshorst, W. J., and C. W. Gottschalk. "Glomerular ultrafiltration dynamics: historical perspective." American Journal of Physiology-Renal Physiology 248, no. 2 (1985): F163—F174. http://dx.doi.org/10.1152/ajprenal.1985.248.2.f163.

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Our knowledge of the structure and function of the renal glomerulus is reviewed in a historical context. The glomerular corpuscles were first described by Malpighi in 1666. Subsequent injection studies led to conflicting claims concerning a glomerular-tubular connection. This connection was accepted only after the convincing demonstration of the anatomical relationship essentially as we now know it by Bowman in 1842. Ludwig was the first to propose that the mechanism of separation of fluid in the glomeruli was by ultrafiltration. Estimates of the ultrafiltration forces in mammals led to confli

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3

Dong, Jianghu J., Liangliang Wang, Jagbir Gill, and Jiguo Cao. "Functional principal component analysis of glomerular filtration rate curves after kidney transplant." Statistical Methods in Medical Research 27, no. 12 (2017): 3785–96. http://dx.doi.org/10.1177/0962280217712088.

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This article is motivated by some longitudinal clinical data of kidney transplant recipients, where kidney function progression is recorded as the estimated glomerular filtration rates at multiple time points post kidney transplantation. We propose to use the functional principal component analysis method to explore the major source of variations of glomerular filtration rate curves. We find that the estimated functional principal component scores can be used to cluster glomerular filtration rate curves. Ordering functional principal component scores can detect abnormal glomerular filtration r

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Squarer, A., K. V. Lemley, S. Ambalavanan, et al. "Mechanisms of progressive glomerular injury in membranous nephropathy." Journal of the American Society of Nephrology 9, no. 8 (1998): 1389–98. http://dx.doi.org/10.1681/asn.v981389.

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Glomerular function and structure were serially evaluated in 15 patients with membranous nephropathy who exhibited relapsing nephrosis and chronic depression of GFR. GFR declined from 56+/-8 (mean+/-SEM) at onset to 31+/-4 ml/min per 1.73 m2 after a 2- to 5-yr period of observation (P < 0.05). An analysis of filtration dynamics suggested persistent elevation of net ultrafiltration pressure. To examine a possible role for declining intrinsic glomerular filtration capacity as the basis for the observed hypofiltration, glomeruli in the baseline and a repeat biopsy (performed after a median of

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Drummond, I. A., A. Majumdar, H. Hentschel, et al. "Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function." Development 125, no. 23 (1998): 4655–67. http://dx.doi.org/10.1242/dev.125.23.4655.

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The zebrafish pronephric kidney provides a simplified model of nephron development and epithelial cell differentiation which is amenable to genetic analysis. The pronephros consists of two nephrons with fused glomeruli and paired pronephric tubules and ducts. Nephron formation occurs after the differentiation of the pronephric duct with both the glomeruli and tubules being derived from a nephron primordium. Fluorescent dextran injection experiments demonstrate that vascularization of the zebrafish pronephros and the onset of glomerular filtration occurs between 40 and 48 hpf. We isolated fifte

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Anderson, W. P., D. Alcorn, A. I. Gilchrist, J. M. Whiting, and G. B. Ryan. "Glomerular actions of ANG II during reduction of renal artery pressure: a morphometric analysis." American Journal of Physiology-Renal Physiology 256, no. 6 (1989): F1021—F1026. http://dx.doi.org/10.1152/ajprenal.1989.256.6.f1021.

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The glomeruli of kidneys subjected to reduced perfusion pressure were examined morphometrically. The left renal artery was narrowed for 30 min in anesthetized dogs with (n = 6) or without (n = 7) converting-enzyme inhibition (captopril). The kidneys were then rapidly fixed by glutaraldehyde perfusion at high flow rate. In a comparison of glomeruli of kidneys subjected to pressure reduction in captopril-treated and untreated dogs, there was significantly greater mesangial contraction in the latter, but morphometric analysis revealed no significant differences in the glomerular surface area avai

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7

Scharschmidt, L. A., J. G. Douglas, and M. J. Dunn. "Angiotensin II and eicosanoids in the control of glomerular size in the rat and human." American Journal of Physiology-Renal Physiology 250, no. 2 (1986): F348—F356. http://dx.doi.org/10.1152/ajprenal.1986.250.2.f348.

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We examined the possibility that glomerular prostaglandin E2 (PGE2) regulates the action of angiotensin II (ANG II) on mesangial contraction and filtration surface area. Using isolated rat glomeruli we indirectly assessed mesangial contraction and filtration surface area through measurements of glomerular planar surface area (GPSA) by image-analysis microscopy. ANG II reduced GPSA by approximately 20% in human and rat glomeruli, with threshold concentrations of 1 X 10(-13) M and maximum effect at 5 X 10(-11) M ANG II. Inhibition of glomerular PG synthesis with indomethacin or meclofenamate pot

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8

Uchio-Yamada, Kozue, Keiko Yasuda, Yoko Monobe, Ken-ichi Akagi, Osamu Suzuki, and Noboru Manabe. "Tensin2 is important for podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier." American Journal of Physiology-Renal Physiology 318, no. 6 (2020): F1520—F1530. http://dx.doi.org/10.1152/ajprenal.00055.2020.

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Tensin2 (Tns2), an integrin-linked protein, is enriched in podocytes within the glomerulus. Previous studies have revealed that Tns2-deficient mice exhibit defects of the glomerular basement membrane (GBM) soon after birth in a strain-dependent manner. However, the mechanisms for the onset of defects caused by Tns2 deficiency remains unidentified. Here, we aimed to determine the role of Tns2 using newborn Tns2-deficient mice and murine primary podocytes. Ultrastructural analysis revealed that developing glomeruli during postnatal nephrogenesis exhibited abnormal GBM processing due to ectopic l

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9

Myers, B. D., and L. Newton. "Cyclosporine-induced chronic nephropathy: an obliterative microvascular renal injury." Journal of the American Society of Nephrology 2, no. 2 (1991): S45. http://dx.doi.org/10.1681/asn.v22s45.

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Physiologic and morphologic techniques have been used to study kidneys of 200 cardiac transplant recipients treated with either low- or high-dose cyclosporine. After 12 months, both low- (4.6 +/- 0.4) and high-dose cyclosporine (6.3 +/- 0.3 mg/kg/24 h; P less than 0.01) were associated with depression of glomerular filtration rate below values in a third group of 100 recipients never exposed to cyclosporine by 40 to 47%. Determination of renovascular pressures and flows as well as analysis of transglomerular sieving of dextrans revealed renal vascular resistance in cyclosporine-treated recipie

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10

Hladunewich, M. A., R. A. Lafayette, G. C. Derby, et al. "The dynamics of glomerular filtration in the puerperium." American Journal of Physiology-Renal Physiology 286, no. 3 (2004): F496—F503. http://dx.doi.org/10.1152/ajprenal.00194.2003.

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We evaluated the glomerular filtration rate (GFR) during the second postpartum week in 22 healthy women who had completed an uncomplicated pregnancy. We used physiological techniques to measure GFR, renal plasma flow, and oncotic pressure and computed a value for the two-kidney ultrafiltration coefficient ( Kf). We compared these findings with those in pregnant women previously studied on the first postpartum day as well as nongravid women of reproductive age. Healthy female transplant donors of reproductive age permitted the morphometric analysis of glomeruli and computation of the single-nep

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11

Murphy, M. J., S. C. Brown, N. B. Clark, and J. Q. Feng. "Compartmental analysis and glomerular filtration in chick embryos." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 261, no. 6 (1991): R1478—R1483. http://dx.doi.org/10.1152/ajpregu.1991.261.6.r1478.

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We have developed microtechniques that allow the determination of compartmental fluid distribution and glomerular filtration rate in chick embryos during three significant developmental periods: phase 1, the developmental period when the mesonephros alone is functioning; phase 2, periods of simultaneous meso/metanephric kidney function; and phase 3, the period during late development when the metanephros completely replaces the degenerated mesonephros. Water content of tissues is greater in younger embryos (89.4 +/- 0.2%, day 10) compared with older animals (78.3 +/- 0.5%, day 18). Although al

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12

Drumond, M. C., and W. M. Deen. "Analysis of pulsatile pressures and flows in glomerular filtration." American Journal of Physiology-Renal Physiology 261, no. 3 (1991): F409—F419. http://dx.doi.org/10.1152/ajprenal.1991.261.3.f409.

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Previous mathematical models of glomerular filtration have ignored the pulsatility of the glomerular capillary pressure, using only steady-state equations and time-averaged pressures and flows. Because the actual pressure pulses are rapid and of large amplitude and because the governing equations are nonlinear, it is questionable whether the effects of the pressure pulses average out in the manner that has been assumed. We have developed a model that includes sinusoidal variations in the glomerular transcapillary hydraulic pressure (delta P) and the afferent arteriolar plasma flow rate over ea

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Pagtalunan, M. E., R. Rasch, H. G. Rennke, and T. W. Meyer. "Morphometric analysis of effects of angiotensin II on glomerular structure in rats." American Journal of Physiology-Renal Physiology 268, no. 1 (1995): F82—F88. http://dx.doi.org/10.1152/ajprenal.1995.268.1.f82.

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Micropuncture and morphometric studies related the effects of angiotensin II (ANG II) on glomerular function and structure. Compared with control animals, rats receiving an intrarenal infusion of ANG II at 40 ng.kg-1.min-1 exhibited a marked reduction in the glomerular ultrafiltration coefficient (Kf) (0.84 +/- 0.13 vs. 1.43 +/- 0.05 microliters.s-1.mmHg-1, ANG II vs. control), which caused a decrease in glomerular filtration rate (GFR) (1.04 +/- 0.11 vs. 1.27 +/- 0.11 ml/min) despite an increase in glomerular transcapillary hydraulic pressure difference (46 +/- 1 vs. 40 +/- 1 mmHg). Morphomet

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14

Mottl, Amy K., Suma Vupputuri, Shelley A. Cole, et al. "Linkage analysis of glomerular filtration rate in American Indians." Kidney International 74, no. 9 (2008): 1185–91. http://dx.doi.org/10.1038/ki.2008.410.

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15

Guasch, A., R. K. Sibley, P. Huie, and B. D. Myers. "Extent and course of glomerular injury in human membranous glomerulopathy." American Journal of Physiology-Renal Physiology 263, no. 6 (1992): F1034—F1043. http://dx.doi.org/10.1152/ajprenal.1992.263.6.f1034.

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Glomerular permselectivity and dynamics were evaluated serially in 14 nephrotic patients with membranous glomerulopathy (MG). Analysis of transglomerular dextran sieving, before and again after proteinuria remitted, revealed persistent depression by 60-80% of glomerular pore density and the two-kidney ultrafiltration coefficient, Kf. The glomerular filtration rate was lowered by half on each occasion. Morphometric examination of glomeruli in a second group of 16 nephrotic patients with MG revealed a low prevalence of glomerulosclerosis (5 +/- 3%) and a twofold increase in filtration surface du

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16

Rahmawati, Febtarini. "Aspek Laboratorium Gagal Ginjal Kronik." Jurnal Ilmiah Kedokteran Wijaya Kusuma 6, no. 1 (2018): 14. http://dx.doi.org/10.30742/jikw.v6i1.323.

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Chronic renal disease is a disorder of renal function or structure that lasts for more than three months, accompanied by a decrease in glomerular filtration rate. Decreasing of renal function monitoring is performed by measuring glomerular filtration rate, determining blood urea, creatinine, creatinine clearance, electrolytes, uric acid, blood gas analysis and tubular function. The Recent method for measuring glomerular filtration rate using inulin clearance, however, is not efficient. Further measurements of creatinine glomerular filtration rate were developed. Measurements of urea, creatinin

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17

Detsika, Maria G., Vasiliki Lygirou, Vassileios Frantzis, et al. "Effect of Heme Oxygenase-1 Deficiency on Glomerular Proteomics." American Journal of Nephrology 43, no. 6 (2016): 441–50. http://dx.doi.org/10.1159/000446859.

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Background: The cytoprotective effect of heme oxygenase (HO)-1 in various forms of renal glomerular injury is established. However, little is known on the role of HO-1 in preserving glomerular structural/functional integrity in the absence of injury. The present study addressed this question in HO-1-deficient rats. Methods: HO-1-deficient rats were generated using zinc finger nuclease-mediated HO-1 gene (Hmox1) disruption and studied. Glomeruli were isolated from HO-1-deficient (Hmox1-/-) rats and their wild type (WT) littermates for proteomic analysis. Results: Glomerular lesions were charact

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18

Guasch, A., H. Hashimoto, R. K. Sibley, W. M. Deen, and B. D. Myers. "Glomerular dysfunction in nephrotic humans with minimal changes or focal glomerulosclerosis." American Journal of Physiology-Renal Physiology 260, no. 5 (1991): F728—F737. http://dx.doi.org/10.1152/ajprenal.1991.260.5.f728.

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Fractional clearances (theta) of uncharged dextrans (radii 28-60 A) were used to characterize glomerular dysfunction in 34 nephrotic humans with either minimal-change nephropathy (MCN) or focal, segmental glomerulosclerosis (FSGS). A theoretical analysis of theta of dextran with a heteroporous membrane model revealed a similar alteration, more marked in FSGS than MCN. The number of restrictive pores perforating the major membrane component was reduced in parallel with the prevailing glomerular filtration rate (GFR). Parallel shuntlike pores in the remaining membrane component were more promine

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A. Molitoris, Bruce, Daniel J. Meier, Exing Wang, Ruben M. Sandoval, Erinn Sheridan, and James S. Strickland. "Quantifying Glomerular Filtration Rates: Kidney Function Analysis Method and Apparatus." Recent Patents on Biomarkerse 2, no. 3 (2012): 209–18. http://dx.doi.org/10.2174/2210309011202030209.

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20

Lee, M., J. L. Saver, K. H. Chang, H. W. Liao, S. C. Chang, and B. Ovbiagele. "Low glomerular filtration rate and risk of stroke: meta-analysis." BMJ 341, sep30 1 (2010): c4249. http://dx.doi.org/10.1136/bmj.c4249.

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21

Mineev, V. N., A. A. Kuzmina, and T. M. Lalaeva. "Apelin/APJ signal system and glomerular filtration rate in various variants of bronchial asthma." Nephrology (Saint-Petersburg) 24, no. 4 (2020): 55–60. http://dx.doi.org/10.36485/1561-6274-2020-24-4-55-60.

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INTRODUCTION. We have previously postulated the similarity of molecular pathogenetic mechanisms in bronchial asthma (BA) and chronic kidney disease (CKD). Understanding these mechanisms in such a comorbidity pathology is of interest to the clinicians. In recent years, the attention of BA pathogenesis researchers has attracted low-investigated adipokine – apelin. On the other hand, apelin is considered as a renoprotective adipokine that can prevent the progression of CKD. THE AIM of the study is to identify the relationship between apelin/APJ signaling system and glomerular filtration rate in d

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Chang, Chia-Jung, Pi-Chao Wang, Tzou-Chi Huang, and Akiyoshi Taniguchi. "Change in Renal Glomerular Collagens and Glomerular Filtration Barrier-Related Proteins in a Dextran Sulfate Sodium-Induced Colitis Mouse Model." International Journal of Molecular Sciences 20, no. 6 (2019): 1458. http://dx.doi.org/10.3390/ijms20061458.

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Renal disease is not rare among patients with inflammatory bowel disease (IBD) and is gaining interest as a target of research. However, related changes in glomerular structural have rarely been investigated. This study was aimed at clarifying the changes in collagens and glomerular filtration barrier (GFB)-related proteins of glomeruli in a dextran sulfate sodium (DSS)-induced colitis mouse model. Acute colitis was induced by administering 3.5% DSS in Slc:ICR strain mice for eight days. Histological changes to glomeruli were examined by periodic acid-Schiff (PAS) and Masson’s trichrome staini

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Asmar, Ali, Lene Simonsen, Meena Asmar, et al. "Glucagon-like peptide-1 does not have acute effects on central or renal hemodynamics in patients with type 2 diabetes without nephropathy." American Journal of Physiology-Endocrinology and Metabolism 310, no. 9 (2016): E744—E753. http://dx.doi.org/10.1152/ajpendo.00518.2015.

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During acute administration of native glucagon-like peptide-1 (GLP-1), we previously demonstrated central hemodynamic effects in healthy males, whereas renal hemodynamics, despite renal uptake of GLP-1 in excess of glomerular filtration, was unaffected. In the present study, we studied hemodynamic effects of GLP-1 in patients with type 2 diabetes under fixed sodium intake. During a 3-h infusion of GLP-1 (1.5 pmol·kg−1·min−1) or saline, intra-arterial blood pressure and heart rate were measured continuously, concomitantly with cardiac output estimated by pulse contour analysis. Renal plasma flo

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Serudji, Joserizal, and Rizanda Machmud. "PERBANDINGAN KEJADIAN PENINGKATAN TEKANAN DARAH PADA TRIMESTER II BERDASARKAN LAJU FILTRASI GLOMERULUS (LFG)." JOURNAL OBGIN EMAS 3, no. 1 (2019): 15–26. http://dx.doi.org/10.25077/aoj.3.1.15-26.2019.

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During normal pregnancy, glomerolus filtration rate (GFR) is increased so that the concentration of urea and creatinine decreased. With the onset of hypertension in pregnancy, renal perfusion and glomerular filtration decreases, the greater of decline showed more severe illness. This was an observational analytic study with Cohort design and performed in Obgyn Department of M. Djamil Hospital Padang, general district hospital in Batusangkar and Achmad Mukhtar, Private Practice Midwife in Batusangkar from June-December 2014. 100 samples of first trimester of pregnancy, each subject were examine

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Syutkin, V. E., A. A. Salienko, O. D. Olisov, S. V. Zhuravel, and M. S. Novruzbekov. "The effect of early everolimus administration on the renal function while reducing the dosage of calcineurin inhibitors in liver transplant recipients in a long-term follow-up." Transplantologiya. The Russian Journal of Transplantation 13, no. 2 (2021): 121–29. http://dx.doi.org/10.23873/2074-0506-2021-13-2-121-129.

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Introduction. The lifelong use of calcineurin inhibitors in liver transplant recipients leads to an increased incidence of chronic kidney disease.Objective. To compare the changes in glomerular filtration rate over five years in liver transplant recipients between those on everolimus with a reduced exposure to calcineurin inhibitors and those on standard doses of calcineurin inhibitors.Material and methods. Fourteen liver transplant recipient switched to everolimus with a minimization of calcineurin inhibitors exposure in the first months after liver transplantation from February 2009 to Febru

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Deng, Aihua, and Scott C. Thomson. "Renal NMDA receptors independently stimulate proximal reabsorption and glomerular filtration." American Journal of Physiology-Renal Physiology 296, no. 5 (2009): F976—F982. http://dx.doi.org/10.1152/ajprenal.90391.2008.

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N-methyl-d-aspartate receptors (NMDA) are expressed in the kidney, where little is known of their functional role. Several series of micropuncture experiments were performed in hydropenic rats using the NMDA channel blocker, MK801, and the NMDA coagonist, l-glycine, to probe NMDA for effects on single-nephron glomerular filtration rate (SNGFR) and proximal reabsorption ( Jprox). During intravenous infusion of MK801 or l-glycine, Henle's loop was perfused to manipulate SNGFR via tubuloglomerular feedback (TGF), thereby facilitating analysis of glomerulotubular balance. To confirm local actions

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Satchell, Simon C., Steve J. Harper, John E. Tooke, Dontscho Kerjaschki, Moin A. Saleem, and Peter W. Mathieson. "Human Podocytes Express Angiopoietin 1, a Potential Regulator of Glomerular Vascular Endothelial Growth Factor." Journal of the American Society of Nephrology 13, no. 2 (2002): 544–50. http://dx.doi.org/10.1681/asn.v132544.

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ABSTRACT. Vascular endothelial growth factor (VEGF) is abundantly expressed by podocytes, but its role in glomeruli is unknown. Angiopoietins are endothelial cell growth factors that function in concert with VEGF but have not previously been observed in human glomeruli. Angiopoietin 1 (Ang1) acts via the endothelial receptor Tie2 to promote maturation and stabilization of blood vessels, resisting angiogenesis and opposing some actions of VEGF. Ang1, Ang2, Tie2, and VEGF expression in normal human renal cortex was examined with immunofluorescence and immunohistochemical analyses. High-power, mu

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Pedersen, M. Mau, J. Sandahl Christiansen, E. B. Pedersen, and C. E. Mogensen. "Determinants of intra-individual variation in kidney function in normoalbuminuric insulin-dependent diabetic patients: importance of atrial natriuretic peptide and glycaemic control." Clinical Science 83, no. 4 (1992): 445–51. http://dx.doi.org/10.1042/cs0830445.

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1. In order to investigate the modulation of kidney function in insulin-dependent diabetes mellitus, intra-individual variation in glomerular filtration rate, renal plasma flow, urinary albumin excretion rate and mean arterial blood pressure was assessed in 22 normoalbuminuric patients [age 31 ± 8 years, duration of diabetes 9 ± 5 years, mean arterial blood pressure 90 ± 5 mmHg (means ± sd), urinary albumin excretion rate 5.4 × / ÷ 1.6 μg/min]. The variation in these parameters was calculated from the results of two clearance studies (continuous infusion of [125I]-iothalamate and 131I-hippuran

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Austin, S. M., J. S. Lieberman, L. D. Newton, M. Mejia, W. A. Peters, and B. D. Myers. "Slope of serial glomerular filtration rate and the progression of diabetic glomerular disease." Journal of the American Society of Nephrology 3, no. 7 (1993): 1358–70. http://dx.doi.org/10.1681/asn.v371358.

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Glomerular function was evaluated longitudinally over a 24- to 48-month period in 18 patients with diabetic glomerular disease (DGD) manifested by proteinuria. GFR was determined by iothalamate clearance at 4-month intervals. The patients were divided into two groups: Group 1 (N = 9) had subnephrotic proteinuria and an initially normal GFR of 91 +/- 8 mL/min. Group 2 (N = 9) had nephrotic-range proteinuria, and initial GFR was reduced to 53 +/- 5 mL/min. Serial GFR fluctuated over time in Group 1, but no trend towards hypofiltration was evident. In contrast, GFR declined linearly in Group 2 at

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Ferro, Charles J., James Hodson, Jason Moore, et al. "Bayesian Analysis of Glomerular Filtration Rate Trajectories in Kidney Transplant Recipients." Transplantation 99, no. 3 (2015): 533–39. http://dx.doi.org/10.1097/tp.0000000000000377.

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Myers, B. D., A. Chagnac, H. Golbetz, L. Newton, S. Strober, and R. K. Sibley. "Extent of glomerular injury in active and resolving lupus nephritis: a theoretical analysis." American Journal of Physiology-Renal Physiology 260, no. 5 (1991): F717—F727. http://dx.doi.org/10.1152/ajprenal.1991.260.5.f717.

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Patients with diffuse, proliferative lupus nephritis (DPLN) were subjected to differential solute clearances (n = 22) and serial renal biopsy (n = 11) before and again after 6-12 mo of immunosuppressive therapy. Glomerular sieving of dextrans of graded size was analyzed with a heteroporous membrane model. This revealed active DPLN to be associated with 1) a reduction of overall pore density accompanied by a 53% depression of glomerular filtration rate (GFR), and 2) appearance of a subset of large, nondiscriminatory pores, which accounted for the observed nephrotic level of proteinuria. Morphom

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LAFAYETTE, RICHARD A., TAHIRA MALIK, MAURICE DRUZIN, GERALDINE DERBY, and BRYAN D. MYERS. "The Dynamics of Glomerular Filtration after Caesarean Section." Journal of the American Society of Nephrology 10, no. 7 (1999): 1561–65. http://dx.doi.org/10.1681/asn.v1071561.

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Abstract. The objective of this study was to determine whether the glomerular hyperfiltration of pregnancy is maintained even after Caesarean section and, if so, to define the responsible hemodynamics. The dynamics of glomerular filtration were evaluated in 12 healthy women who had just completed an uncomplicated pregnancy and were delivered by Caesarean section. Age-matched but non-gravid female volunteers (n = 22) served as control subjects. GFR in postpartum women was elevated above control values by 41%; 149 ± 10 versus 106 ± 3 ml/min per 1.73 m2, respectively (P < 0.001). In contrast,

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Lundqvist, S., S. O. Hietala, C. Berglund, and K. Karp. "Simultaneous Urography and Determination of Glomerular Filtration Rate." Acta Radiologica 35, no. 4 (1994): 391–95. http://dx.doi.org/10.1177/028418519403500415.

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The total plasma clearance of iohexol at urography and 51Cr-EDTA was compared in 31 patients with di- or tetraparesis. A reference 51Cr-EDTA clearance was also performed 24 hours prior to the urography. The GFR was calculated from one, 2 or 4 plasma samples collected 180, 210, 240 and 270 min after the injection. An X-ray fluorescence analyzer was used for the analysis of iohexol in plasma as well as the contrast medium clearance calculations. It was shown that single or multiple sample clearance of iohexol and 51Cr-EDTA were equivalent methods for measurement of the GFR. The GFR was not affec

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Koehler, Sybille, Alexander Kuczkowski, Lucas Kuehne, et al. "Proteome Analysis of Isolated Podocytes Reveals Stress Responses in Glomerular Sclerosis." Journal of the American Society of Nephrology 31, no. 3 (2020): 544–59. http://dx.doi.org/10.1681/asn.2019030312.

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BackgroundUnderstanding podocyte-specific responses to injury at a systems level is difficult because injury leads to podocyte loss or an increase of extracellular matrix, altering glomerular cellular composition. Finding a window into early podocyte injury might help identify molecular pathways involved in the podocyte stress response.MethodsWe developed an approach to apply proteome analysis to very small samples of purified podocyte fractions. To examine podocytes in early disease states in FSGS mouse models, we used podocyte fractions isolated from individual mice after chemical induction

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Buckheit, J. B., R. A. Olshen, K. Blouch, and B. D. Myers. "Modeling of progressive glomerular injury in humans with lupus nephritis." American Journal of Physiology-Renal Physiology 273, no. 1 (1997): F158—F169. http://dx.doi.org/10.1152/ajprenal.1997.273.1.f158.

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We studied glomerular function longitudinally for 36-120 mo in 21 patients undergoing treatment for diffuse, proliferative lupus nephritis. We determined glomerular filtration rate (GFR) and glomerular oncotic pressure (IIGC) and computed the two-kidney ultrafiltration coefficient (Kf) at 6- to 12-mo intervals. The relationships and cross talk among the three variables over time were then analyzed by eigenfunction regression and canonical correlations. We also performed a morphometric analysis of serial biopsies and computed single-nephron Kf in patent glomeruli at baseline and after 36-94 mo

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Nishad, Rajkishor, Prajakta Meshram, Ashish Kumar Singh, G. Bhanuprakash Reddy, and Anil Kumar Pasupulati. "Activation of Notch1 signaling in podocytes by glucose-derived AGEs contributes to proteinuria." BMJ Open Diabetes Research & Care 8, no. 1 (2020): e001203. http://dx.doi.org/10.1136/bmjdrc-2020-001203.

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IntroductionAdvanced glycation end-products (AGEs) are implicated in the pathogenesis of diabetic nephropathy (DN). Previous studies have shown that AGEs contribute to glomerulosclerosis and proteinuria. Podocytes, terminally differentiated epithelial cells of the glomerulus and the critical component of the glomerular filtration barrier, express the receptor for AGEs (RAGE). Podocytes are susceptible to severe injury during DN. In this study, we investigated the mechanism by which AGEs contribute to podocyte injury.Research design and methodsGlucose-derived AGEs were prepared in vitro. Reacti

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Verma, Neena, Chandra Shekhar Lal, Vidyanand Rabidas, et al. "Microalbuminuria and Glomerular Filtration Rate in Paediatric Visceral Leishmaniasis." BioMed Research International 2013 (2013): 1–4. http://dx.doi.org/10.1155/2013/498918.

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Visceral leishmaniasis, caused byLeishmania donovani, is a serious form of leishmaniasis and fatal if untreated. Nearly half of the VL cases are children. There are very few studies of renal function in pediatric visceral leishmaniasis. The aim of this study was to evaluate renal dysfunction by studying glomerular filtration rate (GFR), microalbuminuria, and microscopic examination of urine. Laboratory analysis was performed on blood and urine samples of 40 parasitologically confirmed pediatric VL cases. Laboratory data of urine examination showed albuminuria in 10% (4/40), white blood cells i

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Wu, Jingyang, Jin Geng, Limin Liu, Weiping Teng, Lei Liu, and Lei Chen. "The Relationship between Estimated Glomerular Filtration Rate and Diabetic Retinopathy." Journal of Ophthalmology 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/326209.

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Diabetic retinopathy (DR) is the leading cause of visual impairment and blindness in working-aged people. Several studies have suggested that glomerular filtration rate (GFR) was correlated with DR. This is a hospital-based study and the aim of it was to examine the relationship between the GFR and DR in patients with type 2 diabetes mellitus (T2DM). We used CKD-EPI equation to estimate GFR and SPSS 19.0 and EmpowerStats software to assess their relationship. Among the 1613 participants (aged 54.75 ± 12.19 years), 550 (34.1%) patients suffered from DR. The multivariate analysis revealed that t

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Remuzzi, A., B. M. Brenner, V. Pata, et al. "Three-dimensional reconstructed glomerular capillary network: blood flow distribution and local filtration." American Journal of Physiology-Renal Physiology 263, no. 3 (1992): F562—F572. http://dx.doi.org/10.1152/ajprenal.1992.263.3.f562.

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We developed a mathematical model to simulate blood flow and filtration in individual capillary segments of a glomerular network reconstructed from a normal Munich-Wistar (MW) rat. Three-dimensional geometric reconstruction was obtained by semithin serial sections (1 micron) of one glomerulus after perfusion fixation of kidney. Photomicrographs of each section were digitized and processed, using a computer-based image-analysis system, to derive the topological organization of the capillary network and mean diameter and length of individual capillary segments. Blood flow rate in capillary segme

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Hanke, Nils, Lynne Staggs, Patricia Schroder, et al. "“Zebrafishing” for Novel Genes Relevant to the Glomerular Filtration Barrier." BioMed Research International 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/658270.

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Data for genes relevant to glomerular filtration barrier function or proteinuria is continually increasing in an era of microarrays, genome-wide association studies, and quantitative trait locus analysis. Researchers are limited by published literature searches to select the most relevant genes to investigate. High-throughput cell cultures and otherin vitrosystems ultimately need to demonstrate proof in anin vivomodel. Generating mammalian models for the genes of interest is costly and time intensive, and yields only a small number of test subjects. These models also have many pitfalls such as

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Chen, Sheng-Pyng, Chi-Rong Li, Huan-Cheng Chang, Yu-Ling Li, and Hsiang-Chu Pai. "Relationship Between Metabolic Syndrome Severity and Kidney Function as Related to Gender: A Population-Based Longitudinal Study." Clinical Nursing Research 29, no. 6 (2018): 355–62. http://dx.doi.org/10.1177/1054773818773385.

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The purpose of this study was to explore the relationship between the metabolic syndrome severity Z-score and kidney function by gender. We also examined the estimated glomerular filtration rate in relation to other known risk factors. The study used was a population-based prospective longitudinal research design. A total of 4,838 participants (2,683 females and 2,155 males) included individuals aged >30 years who were undergoing a health examination from 2006 to 2014 in Pingzhen City, Taiwan. In the initial generalized estimated equation model analysis, which included the covariates of age

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Remuzzi, A., C. Battaglia, L. Rossi, C. Zoja, and G. Remuzzi. "Glomerular size selectivity in nephrotic rats exposed to diets with different protein content." American Journal of Physiology-Renal Physiology 253, no. 2 (1987): F318—F327. http://dx.doi.org/10.1152/ajprenal.1987.253.2.f318.

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Glomerular size-selective properties in animals made nephrotic by adriamycin (ADR) injection and fed standard (20% protein) or high-protein (35% protein) diets were investigated using dextran fractional clearances. To interpret filtration and dextran-sieving data, a theoretical approach previously developed for analysis of experimental data in healthy and nephrotic humans was used. Four types of hypothetical pore-radius distributions were compared in order to establish the best tool for describing membrane pore structure in normal and nephrotic rats. This analysis revealed that a spread distri

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Jerebtsova, Marina, Namita Kumari, Yuri Obuhkov, and Sergei Nekhai. "Adenoviral E4 Gene Stimulates Secretion of Pigmental Epithelium Derived Factor (PEDF) that Maintains Long-term Survival of Human Glomerulus-derived Endothelial Cells." Molecular & Cellular Proteomics 11, no. 11 (2012): 1378–88. http://dx.doi.org/10.1074/mcp.m112.020313.

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Renal glomerular endothelial cells are specialized cells with an important role in physiological filtration and glomerular disease. However, maintenance of human primary endothelial cells requires stimulation with serum and growth factors that often results in modification of the cells properties. Previously, expression of early adenovirus region E4 was shown to help maintaining long-term survival of human endothelial cells in serum free media without addition of growth factors. In the current study, we showed that media conditioned with human epithelial cells stably transfected with Ad E4 reg

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Chagnac, Avry, Talia Weinstein, Asher Korzets, Edward Ramadan, Judith Hirsch, and Uzi Gafter. "Glomerular hemodynamics in severe obesity." American Journal of Physiology-Renal Physiology 278, no. 5 (2000): F817—F822. http://dx.doi.org/10.1152/ajprenal.2000.278.5.f817.

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Differential solute clearances were used to characterize glomerular function in 12 nondiabetic subjects with severe obesity (body mass index >38). Nine healthy subjects served as the control group. In the obese group, glomerular filtration rate (GFR) and renal plasma flow (RPF) exceeded the control value by 51 and 31%, respectively. Consequently, filtration fraction increased. The augmented RPF suggested a state of renal vasodilatation involving, mainly or solely, the afferent arteriole. Albumin excretion rate and fractional albumin clearance increased by 89 and 78%, respectively. Oral gluc

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Corbett, Mark, Ana Duarte, Alexis Llewellyn, et al. "Point-of-care creatinine tests to assess kidney function for outpatients requiring contrast-enhanced CT imaging: systematic reviews and economic evaluation." Health Technology Assessment 24, no. 39 (2020): 1–248. http://dx.doi.org/10.3310/hta24390.

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Background Patients with low estimated glomerular filtration rates may be at higher risk of post-contrast acute kidney injury following contrast-enhanced computed tomography imaging. Point-of-care devices allow rapid measurement of estimated glomerular filtration rates for patients referred without a recent estimated glomerular filtration rate result. Objectives To assess the clinical effectiveness and cost-effectiveness of point-of-care creatinine tests for outpatients without a recent estimated glomerular filtration rate measurement who need contrast-enhanced computed tomography imaging. Met

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Faridz, Siska Monika, Syuhada Syuhada, and Akhmad Kheru. "KORELASI KADAR HEMOGLOBIN DENGAN LAJU FILTRASI GLOMERULUS PADA PASIEN GAGAL GINJAL KRONIK STADIUM 3 DAN 4." Jurnal Kebidanan Malahayati 7, no. 3 (2021): 489–94. http://dx.doi.org/10.33024/jkm.v7i3.4113.

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Background Chronic kidney disease was one of the 18 causes of death in 2010. Anemia is a complication of CKD that often occurs even earlier than other complications. Renal dysfunction results in reduced creatinine filtration ability and an increase in serum creatinine.Purpose of this study was to determine the correlation between hemoglobin levels and glomerular filtration rate in patients with stage 3 and 4 chronic kidney failure at Abdul Moeloek Hospital in Bandar Lampung in 2020.Methods This type of research is quantitative with retrospective analytical methods. The research was conducted a

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AMADOR, Victoria Araujo Ganzaroli, Ana Tereza Vaz de Sousa FREITAS, Alessandra Vitorino NAGHETTINI, Edna Regina Silva PEREIRA, and Maria do Rosário Gondim PEIXOTO. "Anthropometric measurements and markers of renal function in adults and older adults." Revista de Nutrição 29, no. 2 (2016): 199–209. http://dx.doi.org/10.1590/1678-98652016000200005.

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Objective: To determine whether anthropometric indicators are associated with markers of renal function in adults and older adults. Methods: This cross-sectional study included 279 adults and older adults attending eight primary healthcare units in eastern Goiânia, Góias. Sociodemographic, lifestyle, and clinical data were collected using a standard questionnaire. Body mass index was categorized as overweight (≥25 kg/m²) or non-overweight. Waist circumference was classified as normal or high; chronic kidney disease was defined as a glomerular filtration rate below 60 mL/minutes/1.73 m²; micro/

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Herman, William H., Steven N. Emancipator, R. L. Patrick Rhoten, and Michael S. Simonson. "Vascular and glomerular expression of endothelin-1 in normal human kidney." American Journal of Physiology-Renal Physiology 275, no. 1 (1998): F8—F17. http://dx.doi.org/10.1152/ajprenal.1998.275.1.f8.

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To understand better the function of endothelin-1 (ET-1) in renal physiology, we examined vascular and glomerular expression of ET-1 in normal human kidney and in lupus nephritis. Immunohistochemical analysis revealed that renal endothelium of glomeruli, arteries, veins, and capillaries expressed ET-1. Endothelial cells were the principal source of glomerular ET-1; positive immunostaining was detected only rarely in mesangial cells and vascular smooth muscle cells from normal kidney. However, mesangial staining for ET-1 was elevated in patients with lupus nephritis, suggesting that under certa

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Gu, Liubao, Liji Huang, Haidi Wu, Qinglin Lou, and Rongwen Bian. "Serum uric acid to creatinine ratio: A predictor of incident chronic kidney disease in type 2 diabetes mellitus patients with preserved kidney function." Diabetes and Vascular Disease Research 14, no. 3 (2017): 221–25. http://dx.doi.org/10.1177/1479164116680318.

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Background: Serum uric acid has shown to be a predictor of renal disease progression in most but not all studies. This study aims to test whether renal function-normalized serum uric acid is superior to serum uric acid as the predictor of incident chronic kidney disease in type 2 diabetes mellitus patients. Methods: In this study, 1339 type 2 diabetes mellitus patients with estimated glomerular filtration rate ⩾60 mL/min/1.73 m2 and normouricemia were included. Renal function-normalized serum uric acid was calculated using serum uric acid/creatinine. Cox regression analysis was used to estimat

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Low, Serena, Xiao Zhang, Jiexun Wang, et al. "Long-term prospective observation suggests that glomerular hyperfiltration is associated with rapid decline in renal filtration function: A multiethnic study." Diabetes and Vascular Disease Research 15, no. 5 (2018): 417–23. http://dx.doi.org/10.1177/1479164118776465.

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Aim: Glomerular hyperfiltration usually occurs early in development of kidney complications in diabetes. To understand hyperfiltration as a marker of renal disease progression in type 2 diabetes mellitus, we aimed to examine association between glomerular hyperfiltration (estimated glomerular filtration rate ⩾ 120 mL/min/1.73 m2) and rapid renal decline (annual estimated glomerular filtration rate loss ⩾ 3 mL/min/1.73 m2). Methods: This was a prospective cohort comprising 1014 patients with type 2 diabetes mellitus attending a Diabetes Centre of a regional hospital in 2002–2014. A separate pro

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