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Journal articles on the topic 'Glomus cell'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 February 2022

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1

Neufeld, Meir, Jacob Pe'er, Eliezer Rosenman, and Moshe Lazar. "Intraorbital Glomus Cell Tumor." American Journal of Ophthalmology 117, no. 4 (1994): 539–41. http://dx.doi.org/10.1016/s0002-9394(14)70022-4.

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2

M, Neufeld, Pe??er J, Rosenman E, and Lazar M. "Intraorbital Glomus Cell Tumor." Journal of Neuro-Ophthalmology 14, no. 4 (1994): 222. http://dx.doi.org/10.1097/00041327-199412000-00037.

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3

Boyacioglu, Hatice, Nagihan Koc, Nihal Avcu, and Ozay Gokoz. "Glomus Tumour of the Lip Mimicking Squamous Cell Carcinoma - A Rare Case Report." Journal of Evolution of Medical and Dental Sciences 10, no. 9 (2021): 649–51. http://dx.doi.org/10.14260/jemds/2021/138.

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Glomus tumour is a rare soft tissue neoplasm arising from glomus body, which is in an arteriovenous anastomosis located particularly in the dermis. This tumour occurs most commonly in hands and feet, and is seldom found in other sites. The purpose of this report is to describe an unusual case of glomus tumour in the lip. A 17-year-old woman with a firm, painless and ulcerated lump in her lower lip was admitted to our clinic. Excisional biopsy was performed, and histopathological analysis revealed the lesion to be a subtype of glomus tumour called as a glomangioma. Most glomus tumours are benig

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4

Roy, Arijit, Jinqing Li, Abu-Bakr Al-Mehdi, Anil Mokashi та Sukhamay Lahiri. "Effect of acute hypoxia on glomus cell E mand ψm as measured by fluorescence imaging". Journal of Applied Physiology 93, № 6 (2002): 1987–98. http://dx.doi.org/10.1152/japplphysiol.00725.2001.

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We have reinvestigated the hypothesis of the relative importance of glomus cell plasma and mitochondrial membrane potentials ( E m and ψm, respectively) in acute hypoxia by a noninvasive fluorescence microimaging technique using the voltage-sensitive dyes bis-oxonol and JC-1, respectively. Short-term (24 h)-cultured rat glomus cells and cultured PC-12 cells were used for the study. Glomus cell E m depolarization was indirectly confirmed by an increase in bis-oxonol (an anionic probe) fluorescence due to a graded increase in extracellular K+. Fluorescence responses of glomus cell E m to acute h

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5

Saxe, Stephen J., Hans E. Grossniklaus, Ted H. Wojno, Gary L. Hertzler, Milton Boniuk, and Ramon L. Font. "Glomus Cell Tumor of the Eyelid." Ophthalmology 100, no. 1 (1993): 139–43. http://dx.doi.org/10.1016/s0161-6420(93)31710-0.

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6

Pribila, Jonathan T. "Glomus Cell Tumor of the Orbit." Archives of Ophthalmology 128, no. 1 (2010): 144. http://dx.doi.org/10.1001/archophthalmol.2009.359.

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7

Zhou, Ting, Ming-Shan Chien, Safa Kaleem, and Hiroaki Matsunami. "Single cell transcriptome analysis of mouse carotid body glomus cells." Journal of Physiology 594, no. 15 (2016): 4225–51. http://dx.doi.org/10.1113/jp271936.

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8

Liao, Zhiwei, Chao Chen, Bingjin Wang, and Cao Yang. "Minimally invasive resection of a glomus tumor of the thoracic spine: a case report and literature review." Journal of International Medical Research 47, no. 6 (2019): 2746–53. http://dx.doi.org/10.1177/0300060519847340.

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Objective Spinal involvement of glomus tumors is extremely rare. We herein present a case of a spinal glomus tumor and reviewed the literature to identify the most effective surgical treatment of spinal glomus tumors. Methods A 48-year-old man presented with a huge paravertebral space-occupying lesion. In this report, we present the diagnostic process and surgical procedure in this case and review the literature of glomus tumors with spine involvement. Results We suspected a primary diagnosis of neurilemmoma based on the imaging results; however, the postoperative pathologic examination confir

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9

PHILIPOV, Stanislav, Ivan MASLARSKI, Mariya KOLEVA-IVANOVA, and Dorian DIKOV. "Glomus coccygeum in pilonidal sinus surgical specimens: report of two rare cases with special reference to SOX10 expression." Anatomy 14, no. 3 (2020): 216–19. http://dx.doi.org/10.2399/ana.20.792465.

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We report two new cases of glomus coccygeum in pilonidal sinus excision specimens. The positive expression of glomus coccygeum cells for SOX10 is used for the first time. SOX10 is a useful immunohistochemical marker for identifying this microanatomical structure, confirming the diagnosis and may help the differential diagnosis. The glomus coccygeum cells are probably neural crest-derived from multipotent Schwann cell precursors.

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10

Li, Yu-Long, Hong Zheng, Yanfeng Ding, and Harold D. Schultz. "Expression of Neuronal Nitric Oxide Synthase in Rabbit Carotid Body Glomus Cells Regulates Large-Conductance Ca2+-Activated Potassium Currents." Journal of Neurophysiology 103, no. 6 (2010): 3027–33. http://dx.doi.org/10.1152/jn.01138.2009.

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Our previous studies show that a decrease in endogenous nitric oxide (NO) is involved in the blunted outward K+ currents in carotid body (CB) glomus cells from chronic heart failure (CHF) rabbits. In the present study, we measured the effects of the neuronal nitric oxide synthase (nNOS) transgene on the K+ currents in CB glomus cells from pacing-induced CHF rabbits. Using single-cell real-time RT-PCR and immunofluorescent techniques, we found that nNOS mRNA and protein are expressed in the rabbit CB glomus cells and CHF decreased the expression of nNOS mRNA and protein in CB glomus cells. Afte

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11

Boileau, M. A., J. C. Grotta, A. Borit, et al. "Metastatic Renal Cell Carcinoma Simulating Glomus Jugulare Tumor." Journal of Urology 139, no. 4 (1988): 877. http://dx.doi.org/10.1016/s0022-5347(17)42669-3.

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12

Ekambar Eshwara Reddy, C., Naresh K. Panda, Gilbert Pragachi, Kusum Joshi, and J. Rajiv Bapuraj. "Petro-occipital Giant Cell Tumour Mimicking Glomus Jugulare." Journal of Otolaryngology 34, no. 05 (2005): 359. http://dx.doi.org/10.2310/7070.2005.34512.

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13

Eyzaguirre, C., Y. Hayashida, and L. Monti-Bloch. "Effects of denervation on the glomus cell membrane." Brain Research 524, no. 1 (1990): 164–70. http://dx.doi.org/10.1016/0006-8993(90)90508-9.

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14

Overholt, Jeffrey L., and Nanduri R. Prabhakar. "Ca2+ Current in Rabbit Carotid Body Glomus Cells Is Conducted by Multiple Types of High-Voltage–Activated Ca2+ Channels." Journal of Neurophysiology 78, no. 5 (1997): 2467–74. http://dx.doi.org/10.1152/jn.1997.78.5.2467.

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Overholt, Jeffrey L. and Nanduri R. Prabhakar. Ca2+ current in rabbit carotid body glomus cells is conducted by multiple types of high-voltage–activated Ca2+ channels. J. Neurophysiol. 78: 2467–2474, 1997. Carotid bodies are sensory organs that detect changes in arterial oxygen. Glomus cells are presumed to be the initial sites for sensory transduction, and Ca2+-dependent neurotransmitter release from glomus cells is believed to be an obligatory step in this response. Some information exists on the Ca2+ channels in rat glomus cells. However, relatively little is known about the types of Ca2+ c

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15

Dagur, Gautam, Kelly Warren, Yimei Miao, Navjot Singh, Yiji Suh, and Sardar A. Khan. "Unusual Glomus Tumor of the Penis." Current Urology 9, no. 3 (2015): 113–18. http://dx.doi.org/10.1159/000442864.

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Introduction: Glomus tumors are benign neoplasms commonly found in subungual regions of the extremities and rarely located in the penis. Misdiagnosis of glomus tumors is common; therefore, symptoms and clinical presentations should be reviewed. Objective: The primary objective of this review article is to emphasize the pathogenesis, pathology, clinical presentation, symptoms, diagnosis, and treatment methods of glomus tumors in order to better identify and manage the condition. Materials and Methods: Research was conducted using PubMed/Medline. The inclusion criteria required glomus tumor to b

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16

Cheng, P. M., and D. F. Donnelly. "Relationship between changes of glomus cell current and neural response of rat carotid body." Journal of Neurophysiology 74, no. 5 (1995): 2077–86. http://dx.doi.org/10.1152/jn.1995.74.5.2077.

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1. Mature rat carotid bodies were harvested and sinus nerve activity was recorded in vitro during superfusion with Ringer saline. Membrane currents of glomus cells were simultaneously recorded using conventional whole cell or perforated-patch whole cell recording. Presumptive glomus cells were identified by the presence of a rapidly activated, voltage-dependent outward current above a threshold of -20 mV. 2. Outward current of presumptive glomus cells was inhibited by tetraethylammonium chloride (TEA) (20 mM) and by verapamil (5-10 microM), consistent with previous studies in which isolated gl

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17

Graadt van Roggen, Joekes, Welvaart, and M van Krieken. "Unusual presentation of multiple subcutaneous glomus tumours of the lower limb with extensive glomus cell hyperplasia." Histopathology 34, no. 5 (1999): 474–75. http://dx.doi.org/10.1046/j.1365-2559.1999.0676c.x.

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18

Stea, A., and C. A. Nurse. "Chloride channels in cultured glomus cells of the rat carotid body." American Journal of Physiology-Cell Physiology 257, no. 2 (1989): C174—C181. http://dx.doi.org/10.1152/ajpcell.1989.257.2.c174.

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As part of our investigations on the chemosensory mechanisms in the rat carotid body, we are studying the physiology of the parenchymal glomus cells by the patch-clamp technique. Here we characterize a large-conductance chloride channel (approximately 296 pS) with random open and closed kinetics in inside-out patches of cultured glomus cells. The open-state probability (Po; mean = 0.61) was hardly affected by membrane potential (-50 to +50 mV) and cytoplasmic calcium (0-1 mM). Similarly, the channel did not appear to be regulated by cytoplasmic nucleotides (1 mM) or pH (6.5-8). Ion-substitutio

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Bishop, Tammie, та Peter J. Ratcliffe. "Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4". Science Signaling 13, № 615 (2020): eaba1302. http://dx.doi.org/10.1126/scisignal.aba1302.

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The mechanistic basis of the marked oxygen sensitivity of glomus cells in the carotid body has long puzzled physiologists. In this issue of Science Signaling, Moreno-Domínguez et al. show the critical importance of high levels of hypoxia-inducible factor, HIF2α/EPAS1, and the nuclear-encoded mitochondrial cytochrome c oxidase subunit, COX4I2, in glomus cell sensitivity to hypoxia.

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20

Błaszkowski, Janusz, Tadeusz Madej, and Mariusz Tadych. "Glomus rubiforme, an arbuscular mycorrhizal fungus new to the mycota of Poland." Acta Mycologica 33, no. 2 (2014): 255–63. http://dx.doi.org/10.5586/am.1998.021.

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<i>Glomus rubiforme</i> is described and illustrated. as well as its occurrence in Poland and in the world is presented. <i>Glomus rubiforme</i> forms pale yellow to light brown spores arranged in blackberry-like sporocarps. The spores develop from a centrally positioned, inflated, thick-walled cell. The spore wall consists of two layers: a sloughing, hyaline outer layer adherent to a coloured, laminated layer. <i>Glomus rubiforme</i> is a new arbuscular mycorrhizal fungus to the mycota of Poland.

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21

Hempleman, S. C. "Increased calcium current in carotid body glomus cells following in vivo acclimatization to chronic hypoxia." Journal of Neurophysiology 76, no. 3 (1996): 1880–86. http://dx.doi.org/10.1152/jn.1996.76.3.1880.

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1. Rat pups were gestated and born in normoxia (inspired O2 pressure 149 mmHg) or chronic hypoxia (insured O2 pressure 80 mmHg) to test whether chronic hypoxia alters carotid body glomus cell calcium currents. Carotid bodies were removed from 5- to 8-day-old-pups under halothane anesthesia, at which time blood hematocrits averaged 52 +/- 1% (mean +/- SE) in the chronically hypoxic pups and 36 +/- 1% in the normoxic pups (P < 0.05). Glomus cells were then enzymatically isolated from the carotid bodies, and calcium currents were recorded with whole cell patch clamp. 2. Compared with normoxic

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22

Ortega-Sáenz, Patricia, Konstantin L. Levitsky, María T. Marcos-Almaraz, Victoria Bonilla-Henao, Alberto Pascual, and José López-Barneo. "Carotid body chemosensory responses in mice deficient of TASK channels." Journal of General Physiology 135, no. 4 (2010): 379–92. http://dx.doi.org/10.1085/jgp.200910302.

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Background K+ channels of the TASK family are believed to participate in sensory transduction by chemoreceptor (glomus) cells of the carotid body (CB). However, studies on the systemic CB-mediated ventilatory response to hypoxia and hypercapnia in TASK1- and/or TASK3-deficient mice have yielded conflicting results. We have characterized the glomus cell phenotype of TASK-null mice and studied the responses of individual cells to hypoxia and other chemical stimuli. CB morphology and glomus cell size were normal in wild-type as well as in TASK1−/− or double TASK1/3−/− mice. Patch-clamped TASK1/3-

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23

Overholt, Jeffrey L., Eckhard Ficker, Tianen Yang, Hashim Shams, Gary R. Bright, and Nanduri R. Prabhakar. "HERG-Like Potassium Current Regulates the Resting Membrane Potential in Glomus Cells of the Rabbit Carotid Body." Journal of Neurophysiology 83, no. 3 (2000): 1150–57. http://dx.doi.org/10.1152/jn.2000.83.3.1150.

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Direct evidence for a specific K+ channel underlying the resting membrane potential in glomus cells of the carotid body has been absent. The product of the human ether-a-go-go–related gene (HERG) produces inward rectifier currents that are known to contribute to the resting membrane potential in other neuronal cells. The goal of the present study was to determine whether carotid body glomus cells express HERG-like K+ current, and if so, to determine whether a HERG-like current regulates the resting membrane potential. Freshly dissociated rabbit glomus cells under whole cell voltage clamp exhib

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24

Conte, Alessandro, Emma Scurrell, and Stephen J. Baines. "Glomus cell tumour on the head of a cat." Journal of Feline Medicine and Surgery Open Reports 4, no. 2 (2018): 205511691880103. http://dx.doi.org/10.1177/2055116918801033.

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Case summary A solitary, sessile, non-ulcerated, freely mobile cutaneous mass approximately 1 cm in diameter on the left temporal region of a 7-year-old neutered female cat was examined. A fine-needle aspirate and wedge biopsy were performed by the referring veterinary surgeon and indicated a neoplasm of uncertain cell lineage. On histopathological examination, the deep dermis contained a discrete, non-encapsulated and vascular neoplasm with morphological and immunophenotypical features typical of a glomus cell tumour. Neoplastic cells were immunopositive for vimentin, muscle actin and smooth

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25

Koske, R. E. "Glomus aggregatum Emended: A Distinct Taxon in the Glomus fasciculatum Complex." Mycologia 77, no. 4 (1985): 619. http://dx.doi.org/10.2307/3793360.

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Koske, R. E. "Glomus Aggregatum Emended: A Distinct Taxon in the Glomus Fasciculatum Complex." Mycologia 77, no. 4 (1985): 619–30. http://dx.doi.org/10.1080/00275514.1985.12025147.

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27

KUSAKABE, Tatsumi. "The occurrence of melanosomes in the newt glomus cell." Archives of Histology and Cytology 54, no. 1 (1991): 81–87. http://dx.doi.org/10.1679/aohc.54.81.

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28

Carroll, John L., and Insook Kim. "Postnatal development of carotid body glomus cell O2 sensitivity." Respiratory Physiology & Neurobiology 149, no. 1-3 (2005): 201–15. http://dx.doi.org/10.1016/j.resp.2005.04.009.

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29

LEVER, L. R., and P. J. A. HOLT. "Multiple glomus cell tumours-treatment by infra-red coagulation." Clinical and Experimental Dermatology 17, no. 1 (1992): 34–35. http://dx.doi.org/10.1111/j.1365-2230.1992.tb02530.x.

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30

Hockman, Dorit, Igor Adameyko, Marketa Kaucka, et al. "Striking parallels between carotid body glomus cell and adrenal chromaffin cell development." Developmental Biology 444 (December 2018): S308—S324. http://dx.doi.org/10.1016/j.ydbio.2018.05.016.

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31

Sobrino, Verónica, Aida Platero-Luengo, Valentina Annese, et al. "Neurotransmitter Modulation of Carotid Body Germinal Niche." International Journal of Molecular Sciences 21, no. 21 (2020): 8231. http://dx.doi.org/10.3390/ijms21218231.

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The carotid body (CB), a neural-crest-derived organ and the main arterial chemoreceptor in mammals, is composed of clusters of cells called glomeruli. Each glomerulus contains neuron-like, O2-sensing glomus cells, which are innervated by sensory fibers of the petrosal ganglion and are located in close contact with a dense network of fenestrated capillaries. In response to hypoxia, glomus cells release transmitters to activate afferent fibers impinging on the respiratory and autonomic centers to induce hyperventilation and sympathetic activation. Glomus cells are embraced by interdigitating pro

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32

Mokashi, A., D. Ray, F. Botre, M. Katayama, S. Osanai, and S. Lahiri. "Effect of hypoxia on intracellular pH of glomus cells cultured from cat and rat carotid bodies." Journal of Applied Physiology 78, no. 5 (1995): 1875–81. http://dx.doi.org/10.1152/jappl.1995.78.5.1875.

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To test the hypothesis that hypoxia may induce cellular acidification during chemotransduction in the carotid body, we compared the effects of hypoxia and of extracellular acidosis on intracellular pH (pHi) of glomus cells cultured from rat and cat carotid bodies. The cells were prepared and cultured for 2–7 days. The plated cells were loaded with a pH-sensitive fluorescent probe, SNARF-1-acetoxymethyl ester, and were placed in a closed chamber and superfused. The effects of lowering PO2 and pH in the superfusion medium containing CO2-HCO3- buffer on the glomus cell pHi were measured at 37 deg

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33

Wang, Nan, Andy K. Lee, Lei Yan, Michael R. Simpson, Amy Tse, and Frederick W. Tse. "Granule matrix property and rapid “kiss-and-run” exocytosis contribute to the different kinetics of catecholamine release from carotid glomus and adrenal chromaffin cells at matched quantal size." Canadian Journal of Physiology and Pharmacology 90, no. 6 (2012): 791–801. http://dx.doi.org/10.1139/y2012-040.

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Catecholamine-containing small dense core granules (SDCGs, vesicular diameter of ∼100 nm) are prominent in carotid glomus (chemosensory) cells and some neurons, but the release kinetics from individual SDCGs has not been studied in detail. In this study, we compared the amperometric signals from glomus cells with those from adrenal chromaffin cells, which also secrete catecholamine but via large dense core granules (LDCGs, vesicular diameter of ∼200–250 nm). When exocytosis was triggered by whole-cell dialysis (which raised the concentration of intracellular Ca2+ ([Ca2+]i) to ∼0.5 µmol/L), the

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34

Sterni, L. M., O. S. Bamford, S. M. Tomares, M. H. Montrose, and J. L. Carroll. "Developmental changes in intracellular Ca2+ response of carotid chemoreceptor cells to hypoxia." American Journal of Physiology-Lung Cellular and Molecular Physiology 268, no. 5 (1995): L801—L808. http://dx.doi.org/10.1152/ajplung.1995.268.5.l801.

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The carotid chemoreceptor response to hypoxia is weak just after birth and increases during postnatal development. The mechanisms underlying chemoreceptor maturation are unknown. We tested the hypothesis that carotid chemoreceptor maturation occurs at the glomus cell level by measuring intracellular calcium ([Ca2+]i) mobilization in response to hypoxia, anoxia, and NaCN in freshly dissociated cells from newborn vs. adult rabbit carotid bodies. Cells were loaded with fura 2 and superfused at 37 degrees C with balanced salt solution equilibrated with 5% CO2. [Ca2+]i mobilization in response to 3

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35

Smith, George S., and N. C. Schenck. "Two New Dimorphic Species in the Endogonaceae: Glomus Ambisporum and Glomus Heterosporum." Mycologia 77, no. 4 (1985): 566–74. http://dx.doi.org/10.1080/00275514.1985.12025142.

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AL-QATTAN, M. M., and H. M. CLARKE. "An Isolated Granular Cell Tumour of the Thumb Pulp Clinically Mimicking a Glomus Tumour." Journal of Hand Surgery 19, no. 4 (1994): 420–21. http://dx.doi.org/10.1016/0266-7681(94)90201-1.

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A rare case of an isolated granular cell tumour of the thumb pulp clinically mimicking a glomus tumour is described. The rationale behind performing oestrogen receptor staining for granular cell tumours is discussed.

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Donnelly, David F. "Developmental aspects of oxygen sensing by the carotid body." Journal of Applied Physiology 88, no. 6 (2000): 2296–301. http://dx.doi.org/10.1152/jappl.2000.88.6.2296.

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The carotid body chemoreceptors, the major hypoxia sensory organs for the respiratory system, undergo a significant increase in their hypoxia responsiveness in the postnatal period. This is manifest by a higher level of afferent nerve activity for a given level of arterial oxygen tension. The mechanism for the enhanced sensitivity is unresolved, but most work has focused on the glomus cell, a secretory cell apposed to the afferent nerve ending and believed to be the site of hypoxia transduction. The glomus cell secretory response to hypoxia increases postnatally, and this is correlated with an

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Di Giulio, C., P. G. Data, and S. Lahiri. "Chronic cobalt causes hypertrophy of glomus cells in the rat carotid body." American Journal of Physiology-Cell Physiology 261, no. 1 (1991): C102—C105. http://dx.doi.org/10.1152/ajpcell.1991.261.1.c102.

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We tested the hypothesis that chronic cobalt administration would induce carotid body cellular response along with polycythemia as found in chronic hypoxia if common oxygen-sensitive mechanisms were involved in the two instances. Morphometric studies were performed on carotid bodies in male rats that were chronically treated with cobalt chloride (0.17 mumol/kg, ip, daily for 6 wk) and in control rats that received blank saline injections. The rats were anesthetized, blood samples were collected for hematocrit, and the carotid bodies were surgically exposed and were perfused and superfused with

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Schwaber, Mitchell K., Gerald S. Gussack, and Wanda Kirkpatrick. "The Role of Radiation Therapy in the Management of Catecholamine-Secreting Glomus Tumors." Otolaryngology–Head and Neck Surgery 98, no. 2 (1988): 150–54. http://dx.doi.org/10.1177/019459988809800209.

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The major source of controversy that surrounds the use of radiation for glomus tumors is the finding of persistent chief cells years after completion of the treatment. Questions have been raised as to the viability of the irradiated chief cell and its capacity to proliferate. The radiotherapists consider a stable glomus tumor a radiation “cure,” whereas skull base surgeons are fearful that these lesions will continue to slowly grow and cause problems 20 to 30 years later. We have recently managed a patient who was not a candidate for surgery, with a catecholamine-secreting glomus jugulare tumo

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Wasicko, M. J., G. E. Breitwieser, I. Kim, and J. L. Carroll. "Postnatal development of carotid body glomus cell response to hypoxia." Respiratory Physiology & Neurobiology 154, no. 3 (2006): 356–71. http://dx.doi.org/10.1016/j.resp.2006.01.003.

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41

Sherpa, A. K., K. H. Albertine, D. G. Penney, B. Thompkins, and S. Lahiri. "Chronic CO exposure stimulates erythropoiesis but not glomus cell growth." Journal of Applied Physiology 67, no. 4 (1989): 1383–87. http://dx.doi.org/10.1152/jappl.1989.67.4.1383.

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The effect of chronic CO exposure, which stimulates erythropoietin production and erythropoiesis, was studied on carotid body cells in the rat. The hypothesis to be tested was that chronic CO inhalation would stimulate cellular hypertrophy and hyperplasia of carotid body if it caused local tissue hypoxia as in chronic hypoxia. The failure of an appropriate response would indicate a lack of a specific local effect on carotid body tissue PO2 presumably because of its unusually high tissue blood flow. Six young male rats were exposed to 0.4–0.5 Torr (0.05–0.07%) inspired PCO in air for 22 days. C

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42

Seo, Jeong Ho, Ho Seong Lee, Sang Woo Kim, Jae Jung Jeong, and Young Rak Choi. "Subungual Glomus Cell Proliferation in the Toe: A Case Report." Journal of Foot and Ankle Surgery 53, no. 5 (2014): 628–30. http://dx.doi.org/10.1053/j.jfas.2014.03.004.

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43

Pusztaszeri, Marc. "Glomus tumor of kidney: differential diagnosis from juxtaglomerular cell tumor." Human Pathology 43, no. 4 (2012): 616. http://dx.doi.org/10.1016/j.humpath.2011.12.009.

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44

Pandit, Jaideep J., Nicky Huskens, Peadar B. O’Donohoe, Philip J. Turner, and Keith J. Buckler. "Competitive Interactions between Halothane and Isoflurane at the Carotid Body and TASK Channels." Anesthesiology 133, no. 5 (2020): 1046–59. http://dx.doi.org/10.1097/aln.0000000000003520.

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Background The degree to which different volatile anesthetics depress carotid body hypoxic response relates to their ability to activate TASK potassium channels. Most commonly, volatile anesthetic pairs act additively at their molecular targets. We examined whether this applied to carotid body TASK channels. Methods We studied halothane and isoflurane effects on hypoxia-evoked rise in intracellular calcium (Ca2+i, using the indicator Indo-1) in isolated neonatal rat glomus cells, and TASK single-channel activity (patch clamping) in native glomus cells and HEK293 cell line cells transiently exp

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Moreno-Domínguez, Alejandro, Patricia Ortega-Sáenz, Lin Gao та ін. "Acute O2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors". Science Signaling 13, № 615 (2019): eaay9452. http://dx.doi.org/10.1126/scisignal.aay9452.

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Acute cardiorespiratory responses to O2 deficiency are essential for physiological homeostasis. The prototypical acute O2-sensing organ is the carotid body, which contains glomus cells expressing K+ channels whose inhibition by hypoxia leads to transmitter release and activation of nerve fibers terminating in the brainstem respiratory center. The mechanism by which changes in O2 tension modulate ion channels has remained elusive. Glomus cells express genes encoding HIF2α (Epas1) and atypical mitochondrial subunits at high levels, and mitochondrial NADH and reactive oxygen species (ROS) accumul

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Wilding, T. J., B. Cheng, and A. Roos. "pH regulation in adult rat carotid body glomus cells. Importance of extracellular pH, sodium, and potassium." Journal of General Physiology 100, no. 4 (1992): 593–608. http://dx.doi.org/10.1085/jgp.100.4.593.

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The course of intracellular pH (pHi) was followed in superfused (36 degrees C) single glomus (type I) cells of the freshly dissociated adult rat carotid body. The cells had been loaded with the pH-sensitive fluorescent dye 2',7'-(2-carboxyethyl)-5 (and -6)-carboxyfluorescein. The high K(+)-nigericin method was used for calibration. The pHi of the glomus cell at pHo 7.40, without CO2, was 7.23 +/- 0.02 (n = 70); in 5% CO2/25 mM HCO3-, pHi was 7.18 +/- 0.08 (n = 9). The pHi was very sensitive to changes in pHo. Without CO2, delta pHi/delta pHo was 0.85 (pHo 6.20-8.00; 32 cells), while in CO2/HCO

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Wu, Chi-Guang, and David M. Sylvia. "Spore Ontogeny of Glomus globiferum." Mycologia 85, no. 2 (1993): 317. http://dx.doi.org/10.2307/3760465.

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Makarenko, Vladislav V., Gias U. Ahmmed, Ying-Jie Peng, et al. "CaV3.2 T-type Ca2+ channels mediate the augmented calcium influx in carotid body glomus cells by chronic intermittent hypoxia." Journal of Neurophysiology 115, no. 1 (2016): 345–54. http://dx.doi.org/10.1152/jn.00775.2015.

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Chronic intermittent hypoxia (CIH) is a hallmark manifestation of sleep apnea. A heightened carotid body activity and the resulting chemosensory reflex mediate increased sympathetic nerve activity by CIH. However, the mechanisms underlying heightened carotid body activity by CIH are not known. An elevation of intracellular calcium ion concentration ([Ca2+]i) in glomus cells, the primary oxygen-sensing cells, is an essential step for carotid body activation by hypoxia. In the present study, we examined the effects of CIH on the glomus cell [Ca2+]i response to hypoxia and assessed the underlying

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Piruat, José I., C. Oscar Pintado, Patricia Ortega-Sáenz, Marta Roche, and José López-Barneo. "The Mitochondrial SDHD Gene Is Required for Early Embryogenesis, and Its Partial Deficiency Results in Persistent Carotid Body Glomus Cell Activation with Full Responsiveness to Hypoxia." Molecular and Cellular Biology 24, no. 24 (2004): 10933–40. http://dx.doi.org/10.1128/mcb.24.24.10933-10940.2004.

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ABSTRACT The SDHD gene encodes one of the two membrane-anchoring proteins of the succinate dehydrogenase (complex II) of the mitochondrial electron transport chain. This gene has recently been proposed to be involved in oxygen sensing because mutations that cause loss of its function produce hereditary familiar paraganglioma, a tumor of the carotid body (CB), the main arterial chemoreceptor that senses oxygen levels in the blood. Here, we report the generation of a SDHD knockout mouse, which to our knowledge is the first mammalian model lacking a protein of the electron transport chain. Homozy

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Chow, Louis Tsun Cheung, Michael Ho Ming Chan, and Simon Kwok Chuen Wong. "Functional Ulnar Nerve Paraganglioma: First Documented Occurrence in the Extremity With Hitherto Undescribed Associated Extensive Glomus Cell Hyperplasia and Tumorlet Formation." International Journal of Surgical Pathology 26, no. 1 (2017): 64–72. http://dx.doi.org/10.1177/1066896917720750.

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Extra-adrenal paraganglioma has never been described in the extremities. A 34-year-old woman complained of an enlarging mass in the right forearm for 18 months. Imaging showed a circumscribed vascular tumor attached to the ulnar nerve; biopsy revealed features of paraganglioma. The resected tumor consisted of zellballen pattern of chief cells staining positively for chromogranin with surrounding S100-positive sustentacular cells. The chief cells contained many neurosecretory granules and mitochondria, whereas the sustentacular cells contained a large amount of rough endoplasmic reticulum and s

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