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Relevant bibliographies by topics / GLP-1 analogues

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Academic literature on the topic 'GLP-1 analogues'

Author: Grafiati

Published: 4 June 2021

Last updated: 31 January 2023

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Journal articles on the topic "GLP-1 analogues"

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Macaulay, D. "Are GLP-1 analogues affordable?" BMJ 342, mar08 3 (2011): d1482. http://dx.doi.org/10.1136/bmj.d1482.

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Korbut, Anton Ivanovich, and Vadim Valerievich Klimontov. "Incretin-based therapy: renal effects." Diabetes mellitus 19, no. 1 (2016): 53–63. http://dx.doi.org/10.14341/dm7727.

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Glucagon like peptide-1 (GLP-1) analogues and dipeptidyl peptidase-4 (DPP-4) inhibitors are new classes of hypoglycemic agents with numerous pleiotropic effects. The review summarises data about the influence of GLP-1 analogues and DPP-4 inhibitors on structural and functional changes in diabetic kidneys. Growing evidence indicates that the kidney is one of the loci of the effects and degradation of GLP-1. The potency of the effects of GLP-1 in diabetic kidneys can be reduced by decrease in GLP-1 receptor expression or enhancement of GLP-1 degradation. In experimental models of diabetic nephro

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Dharmaraj, B. "A brief review on newer Glucagon like Peptide-1 analogues." International Journal of Preclinical and Clinical Research 1, no. 1 (2020): 26–34. http://dx.doi.org/10.51131/ijpccr/v1i1.7.

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GLP-1 (Glucagon like Peptide-1) receptor agonists have been shown to be effective in the treatment of type 2 diabetes mellitus (T2DM). Although the first GLP-1 receptor agonist, Exenatide, was approved in the year 2000, other agents with a longer duration of action that do not require twice-daily dosing are now being developed. Indeed, Liraglutide, a once-daily GLP-1 receptor agonist, was approved in 2010, a once-weekly extended-release formulation of Exenatide (Exenatide ER) was approved in 2011 and now more recently Semaglutide, an oral GLP 1 receptor agonist was approved for medical use in

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Green, BD, VA Gault, MH Mooney, et al. "Novel dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1(7-36)amide have preserved biological activities in vitro conferring improved glucose-lowering action in vivo." Journal of Molecular Endocrinology 31, no. 3 (2003): 529–40. http://dx.doi.org/10.1677/jme.0.0310529.

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Although the incretin hormone glucagon-like peptide-1 (GLP-1) is a potent stimulator of insulin release, its rapid degradation in vivo by the enzyme dipeptidyl peptidase IV (DPP IV) greatly limits its potential for treatment of type 2 diabetes. Here, we report two novel Ala(8)-substituted analogues of GLP-1, (Abu(8))GLP-1 and (Val(8))GLP-1 which were completely resistant to inactivation by DPP IV or human plasma. (Abu(8))GLP-1 and (Val(8))GLP-1 exhibited moderate affinities (IC(50): 4.76 and 81.1 nM, respectively) for the human GLP-1 receptor compared with native GLP-1 (IC(50): 0.37 nM). (Abu(

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Green, BD, MH Mooney, VA Gault, et al. "N-terminal His(7)-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity." Journal of Endocrinology 180, no. 3 (2004): 379–88. http://dx.doi.org/10.1677/joe.0.1800379.

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Glucagon-like peptide-1(7-36)amide (GLP-1) possesses several unique and beneficial effects for the potential treatment of type 2 diabetes. However, the rapid inactivation of GLP-1 by dipeptidyl peptidase IV (DPP IV) results in a short half-life in vivo (less than 2 min) hindering therapeutic development. In the present study, a novel His(7)-modified analogue of GLP-1, N-pyroglutamyl-GLP-1, as well as N-acetyl-GLP-1 were synthesised and tested for DPP IV stability and biological activity. Incubation of GLP-1 with either DPP IV or human plasma resulted in rapid degradation of native GLP-1 to GLP

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Liu, Hongbin, Anthony E. Dear, Lotte B. Knudsen, and Richard W. Simpson. "A long-acting glucagon-like peptide-1 analogue attenuates induction of plasminogen activator inhibitor type-1 and vascular adhesion molecules." Journal of Endocrinology 201, no. 1 (2009): 59–66. http://dx.doi.org/10.1677/joe-08-0468.

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Glucagon-like peptide-1 (GLP-1) administration attenuates endothelial cell dysfunction in diabetic patients and inhibits tumour necrosis factor α (TNF)-mediated plasminogen activator inhibitor type-1 (PAI-1) induction in human vascular endothelial cells. The short half-life of GLP-1 mediated via degradation by the enzyme dipeptidyl peptidase 4 mandates the clinical use of long-acting GLP-1 analogues. The effects of a long-acting GLP-1 analogue on PAI-1 and vascular adhesion molecule expression in vascular endothelial cells are unknown. In this report, we demonstrate for the first time that the

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Carydias, Elisabeth, Andoneta Tasho, Chara Kani, Flora Bacopoulou, Charikleia Stefanaki, and Sophia L. Markantonis. "Systematic Review and Meta-Analysis of the Efficacy and Safety of Metformin and GLP-1 Analogues in Children and Adolescents with Diabetes Mellitus Type 2." Children 9, no. 10 (2022): 1572. http://dx.doi.org/10.3390/children9101572.

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Diabetes mellitus type 2 (DMT2) is one of the most frequent glucose metabolism disorders, in which serum glucose concentrations are increased. In most cases, changes in lifestyle and diet are considered as the first step in addressing its therapy. If changes in lifestyle and diet fail, drugs, such as metformin, must be added. Lately, apart from metformin or insulin, the FDA has approved the use of glucagon-like peptide-1 (GLP-1) analogues for children and adolescents. Little is known about their efficacy and safety at this young age. The main aim of this systematic review/meta-analysis was to

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Yudkin, J. S., R. Lehman, and H. M. Krumholz. "Use of GLP-1 analogues needs great caution." BMJ 342, mar08 3 (2011): d1478. http://dx.doi.org/10.1136/bmj.d1478.

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Brom, Maarten, Lieke Joosten, Wim J. G. Oyen, Martin Gotthardt, and Otto C. Boerman. "Radiolabelled GLP-1 analogues forin vivotargeting of insulinomas." Contrast Media & Molecular Imaging 7, no. 2 (2012): 160–66. http://dx.doi.org/10.1002/cmmi.475.

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Su, Yunfang, Zijuan Zhang, Hao Li, et al. "A GLP-2 Analogue Protects SH-SY5Y and Neuro-2a Cells Against Mitochondrial Damage, Autophagy Impairments and Apoptosis in a Parkinson Model." Drug Research 71, no. 01 (2020): 43–50. http://dx.doi.org/10.1055/a-1266-3263.

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AbstractGlucagon-like peptide-2 (GLP-2) is a peptide hormone that belongs to the glucagon-derived peptide family. We have previously shown that analogues of the sister hormone Glucagon-like peptide-1 (GLP-1) showed neuroprotective effects. Here we investigated the effect of a GLP-2 agonist in a cell model of Parkinsonʼs disease (PD) created by treating SH-SY5Y or Neuro-2a cells with 1-Methyl-4-phenyl-pyridine ion (MPP+). Cell viability and cell cytotoxicity was detected by MTT and LDH assays, respectively. The protein expression levels of mitochondrial, autophagy and apoptotic biomarkers inclu

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Dissertations / Theses on the topic "GLP-1 analogues"

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Lavery, Kerry Susan. "The role and therapeutic potential of GLP-1 analogues as a treatment for type 2 diabetes." Thesis, University of Ulster, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494366.

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Varin, Elodie. "Identification de nouvelles stratégies thérapeutiques renforçant le rôle des analogues du GLP-1 pour préserver et/ou restaurer la masse fonctionnelle β pancréatique". Thesis, Montpellier 1, 2013. http://www.theses.fr/2013MON1T015.

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Les cellules β pancréatiques synthétisent et sécrètent l'insuline, seule hormone hypoglycémiante de l'organisme. Dans le cas du diabète de type 2, du diabète de type 1 et suite à une greffe d'îlots de Langherans, on observe une diminution drastique de cette masse fonctionnelle β. L'hyperglycémie chronique et la libération de cytokines proinflammatoires jouent un rôle cytotoxique prépondérant dans ces phénomènes. Dans le but de préserver ou de restaurer cette masse fonctionnelle β chez les patients diabétiques, notre objectif était d'identifier des outils permettant de protéger des effets délét

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Gleizes, Céline. "Mécanismes et contrôle de la réaction inflammatoire précoce au cours de la greffe d'îlots pancréatiques dans un modèle de lignée de cellules bêta de rat : rôle et modulation de la libération des microparticules." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ082/document.

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La greffe d’îlots pancréatiques est caractérisée par une réponse inflammatoire et procoagulante précoce, connue sous le nom d’IBMIR (Instant Blood Mediated Inflammatory Reaction). Les microparticules (MPs) porteuses de facteur tissulaire (TF) sont le témoin d’un important remodelage membranaire et constituent des acteurs centraux dans la dissémination du stress de l’IBMIR. Nous avons exploré l’effet d’un stress inflammatoire sur la survie et la fonction de la cellule β dans un modèle de communication cellulaire médiée par les MPs. La modulation pharmacologique par les analogues du GLP-1 a été

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Parthsarathy, Vadivel. "Effects of GLP-1 analogue, liraglutide on inflammation, stem cell proliferation, differentiation and cognition in mouse brain." Thesis, Ulster University, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.674740.

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Alzheimer's disease (AD) is the most common form of dementia in the elderly and is characterized as a 'progressive neurodegenerative disorder' with neuronal amyloid deposition and impaired cognitive function. Impaired insulin signaling is one of the many similarities between AD and type 2 diabetes. Currently no effective treatment is on the market for AD and hence novel therapeutic strategies are needed. In this study, effects of GLP-l analogue, liraglutide on neuroinflammation, stem cell proliferation, differentiation and cognition were investigated. Chronic treatment of liraglutide enhanced

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Bellman, Susan Marie. "The effectiveness of GLP-1 analogues compared to DPP-4 inhibitors for beta cell function and diabetes related complications among adults with type 2 diabetes: a systematic review and meta-analysis." Thesis, 2016. http://hdl.handle.net/2440/99884.

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Continued loss of beta cell function is responsible for progressive deterioration of plasma glucose control and complications characteristic of type 2 diabetes. Two classes of incretin-based antihyperglycaemic agents, dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon-like peptide-1(GLP-1) analogues, have shown favourable effects on beta cell function. The aim of this systematic review was to provide a comprehensive synthesis of randomised clinical studies comparing the effectiveness of GLP-1 analogues to DPP-4 inhibitors in improving beta cell function and managing diabetes related compli

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Tsai, Shan-KO, та 蔡善格. "Protective Effects of GLP-1 Analogue (Liraglutide) Against Amyloid β-induced Neurotoxicity". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/xm4zwj.

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碩士<br>中山醫學大學<br>醫學研究所<br>104<br>Alzheimer’s disease (AD) is the most common neurodegenerative disease in the elder population, occupying the highest proportion among all types of dementia. As far as we know, there are two important pathological characteristics in AD patients’ brains including amyloid β (Aβ) and neurofibrillary tangles, that cause great numbers of neuronal cell death leading to shrinkage in affected brain regions resulting in deficits in neuronal function. However, the clinical drugs used on AD patients can’t decrease the neurotoxicity of Aβ but only to relief the clinical symp

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Gonçalves, Andreia Fernandes Dâmaso. "Can DPP-IV Inhibitors or GLP-1 Analogs be Tomorrow’s Therapy for Diabetic Retinopathy?" Doctoral thesis, 2016. http://hdl.handle.net/10316/30614.

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Tese de doutoramento em Engenharia Biomédica, apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra<br>A retinopatia diabética é uma das complicações associadas à diabetes e uma das principais causas de perda de visão na população em idade ativa em todo o mundo. No entanto, os tratamentos disponíveis para esta doença são escassos, invasivos, não eficazes para todos os doentes, apresentam alguns riscos adversos e são normalmente administrados nas fases tardias da retinopatia diabética, quando a visão já se encontra significativamente comprometida. Desta forma, novas estrat

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Tai, Hung-Ju, and 戴弘儒. "(1) Concise Synthesis of Ganglioside Hp-s1 Neu5Ac alpha(2 → 6)Glc alpha(1 → 1)Cer Analogue (2) Preparation of Sphingosine Derivative." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/13551681510024635165.

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碩士<br>國立中興大學<br>化學系所<br>103<br>The synthesis of the ganglioside Hp-s1 analogue by changing the stereochemistry at C-1 position of glucosyl moiety is presented. In order to explore the exact stereochemical role of C-1 position of glucosyl moiety, we synthesized ganglioside analogue having alpha-alpha/alpha-beta configuration from non-reducing to reducing end. The characteristic sequence of the glycolipid part was efficiently assembled by coupling of a highly active benzyl protected glucosyl donor and a phytosphingosine derived acceptor with good -stereoselectivity. The corresponding glycolipid

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Trinh, Nguyen Trieu. "Small molecule inhibitors of the hedgehog signalling pathway as cancer suppressing agents." Thesis, 2016. http://hdl.handle.net/1959.13/1337980.

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Research Doctorate - Doctor of Philosophy (PhD)<br>The HSP plays a pivotal role in the spatial and temporal regulation of cell proliferation and differentiation. Conversely aberrant Hh signalling is involved in Gorlin syndrome, basal cell carcinoma (the most common cancer in the world), and more than one third of all human medulloblastoma cases. In all of these cases, it is believed that deregulated Hh signalling leads to increased cell proliferation and tumour formation. Inhibition of the Hedgehog Signalling Pathway, is a recently validated anti-cancer drug target, with vismodegib (GDC-0449,

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Book chapters on the topic "GLP-1 analogues"

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Gallwitz, Baptist. "Anorexigenic Effects of GLP-1 and Its Analogues." In Handbook of Experimental Pharmacology. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-24716-3_8.

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Knudsen, Lotte B. "Liraglutide, a GLP-1 Analogue to Treat Diabetes." In Analogue-Based Drug Discovery II. Wiley-VCH Verlag GmbH & Co. KGaA, 2010. http://dx.doi.org/10.1002/9783527630035.ch14.

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Maselli, Daniel B., and Michael Camilleri. "Effects of GLP-1 and Its Analogs on Gastric Physiology in Diabetes Mellitus and Obesity." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2020. http://dx.doi.org/10.1007/5584_2020_496.

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Kalra, Sanjay, and Ravi Ghanghas. "GLP-1 Analogues: Monotherapy." In Incretin Based Therapies. Jaypee Brothers Medical Publishers (P) Ltd., 2013. http://dx.doi.org/10.5005/jp/books/11892_5.

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Kalra, Sanjay. "GLP-1 Analogues: An Overview." In Incretin Based Therapies. Jaypee Brothers Medical Publishers (P) Ltd., 2013. http://dx.doi.org/10.5005/jp/books/11892_4.

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Raparti, Girish, and Vageesh Ayyar. "GLP-1 Analogues: Combination Therapy." In Incretin Based Therapies. Jaypee Brothers Medical Publishers (P) Ltd., 2013. http://dx.doi.org/10.5005/jp/books/11892_6.

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Gupta, Vishal. "GLP-1 Analogues and Insulin Combination." In Incretin Based Therapies. Jaypee Brothers Medical Publishers (P) Ltd., 2013. http://dx.doi.org/10.5005/jp/books/11892_7.

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Sivasubramanian, Sakthivel. "GLP-1 Analogues vs. DPP-4 Inhibitors." In Incretin Based Therapies. Jaypee Brothers Medical Publishers (P) Ltd., 2013. http://dx.doi.org/10.5005/jp/books/11892_16.

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Kalra, Sanjay, and Suyog Jain. "Choosing a GLP-1 Analogue." In Incretin Based Therapies. Jaypee Brothers Medical Publishers (P) Ltd., 2013. http://dx.doi.org/10.5005/jp/books/11892_17.

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Diz-Chaves, Yolanda, Salvador Herrera-Pérez, Lucas C. González-Matías, and Federico Mallo. "Effects of Glucagon-like peptide 1 (GLP-1) analogs in the hippocampus." In Vitamins and Hormones. Elsevier, 2022. http://dx.doi.org/10.1016/bs.vh.2021.12.005.

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Conference papers on the topic "GLP-1 analogues"

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Hunter, Robert, Andrew Carpenter, Erin Swiger, et al. "Discovery of Novel and Long Acting GLP-1 Analogs." In The 24th American Peptide Symposium. Prompt Scientific Publishing, 2015. http://dx.doi.org/10.17952/24aps.2015.197.

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Ismail, Ruba, and Ildikó Csóka. "Potential of polymeric and Lipid based nanocarriers for oral GLP-1 analogue delivery." In II. Symposium of Young Researchers on Pharmaceutical Technology,Biotechnology and Regulatory Science. Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 2020. http://dx.doi.org/10.14232/syrptbrs.2020.op9.

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Watchorn, D. C., J. Meurling, G. Nolan, et al. "Inflammatory Mediators in an Asthmatic Population on GLP-1 Analogue Therapy for Weight Management." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1424.

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King, A., C. Arnaud, G. Vial, et al. "The effect of the GLP-1 analogue Liraglutide on intermittent hypoxia-induced systemic insulin resistance in vivo." In ERS International Congress 2022 abstracts. European Respiratory Society, 2022. http://dx.doi.org/10.1183/13993003.congress-2022.2182.

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Suttie, W. J., A. Cheung, and M. G. Wood. "ENZYMOLOGY OF THE VITAMIN K-DEPENDENT CARBOXYLASE: CURRENT STATUS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643991.

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The vitamin K-dependent microsomal carboxylase converts glutamyl residues in precursor proteins to γ-carboxyglutamyl (Gla) residues in completed proteins. The enzyme activity is present in significant activities in most non-skeletal tissues but has been studied most extensively in rat and bovine liver. Early studies of the enzyme utilized bound precursors of vitamin K-dependent clotting factors as substrates for the enzyme and demonstrated that the enzyme requires the reduced form of vitamin K (vitamin KH2), O2, and CO2. Subsequent investigations have taken advantage of the observation that th

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Muftuoglu, Sevda. "The Relationship Between Serum S100B Levels And Microglial Activation In Rat Hipocampus After Lithium-pilocarpine Induced Status Epilepticus And The Effect Of Liraglutide, A GLP-1 Analogue On These Changes." In 15th International Congress of Histochemistry and Cytochemistry. LookUs Scientific, 2017. http://dx.doi.org/10.5505/2017ichc.pp-219.

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Reports on the topic "GLP-1 analogues"

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Luan, Sisi, Wenke Cheng, Chenglong Wang, Hongjian Gong, and Jianbo Zhou. Impact of glucagon-like peptide 1 analogs on cognitive function among patients with type 2 diabetes mellitus. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.6.0015.

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Review question / Objective: Diabetes is an independent risk factor for cognitive impairment. Little is known regarding the neuroprotective effects of glucagon-like peptide 1 (GLP-1) analogs on type 2 diabetes mellitus (T2DM).Here, the study aim to assess the impact of GLP-1 on general cognition function among patients with T2DM. Eligibility criteria: Inclusion criteria were as follows: (1) an original article was recently published in English, (2) the population included subjects diagnosed with diabetes at baseline, (3) GLP-1 analogs is a single formulation rather than a fixed dose combinatio

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