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Journal articles on the topic 'GlucoCEST'

Author: Grafiati

Published: 7 July 2024

Last updated: 31 July 2025

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1

Jin, Tao, Hunter Mehrens, Kristy S. Hendrich, and Seong-Gi Kim. "Mapping Brain Glucose Uptake with Chemical Exchange-Sensitive Spin-Lock Magnetic Resonance Imaging." Journal of Cerebral Blood Flow & Metabolism 34, no. 8 (2014): 1402–10. http://dx.doi.org/10.1038/jcbfm.2014.97.

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Uptake of administered D-glucose (Glc) or 2-deoxy-D-glucose (2DG) has been indirectly mapped through the chemical exchange (CE) between glucose hydroxyl and water protons using CE-dependent saturation transfer (glucoCEST) magnetic resonance imaging (MRI). We propose an alternative technique—on-resonance CE-sensitive spin-lock (CESL) MRI—to enhance responses to glucose changes. Phantom data and simulations suggest higher sensitivity for this ‘glucoCESL’ technique (versus glucoCEST) in the intermediate CE regime relevant to glucose. Simulations of CESL signals also show insensitivity to B0-fluct

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2

Bender, Benjamin, Kai Herz, Anagha Deshmane, et al. "GLINT: GlucoCEST in neoplastic tumors at 3 T—clinical results of GlucoCEST in gliomas." Magnetic Resonance Materials in Physics, Biology and Medicine 35, no. 1 (2021): 77–85. http://dx.doi.org/10.1007/s10334-021-00982-5.

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Abstract Objective Clinical relevance of dynamic glucose enhanced (DGE) chemical exchange saturation transfer (CEST) imaging has mostly been demonstrated at ultra-high field (UHF) due to low effect size. Results of a cohort study at clinical field strength are shown herein. Materials and methods Motion and field inhomogeneity corrected T1ρ‐based DGE (DGE⍴) images were acquired before, during and after a d-glucose injection with 6.3 s temporal resolution to detect accumulation in the brain. Six glioma patients with clear blood–brain barrier (BBB) leakage, two glioma patients with suspected BBB

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3

Kim, Mina, Afroditi Eleftheriou, Luca Ravotto, et al. "What do we know about dynamic glucose-enhanced (DGE) MRI and how close is it to the clinics? Horizon 2020 GLINT consortium report." Magnetic Resonance Materials in Physics, Biology and Medicine 35, no. 1 (2022): 87–104. http://dx.doi.org/10.1007/s10334-021-00994-1.

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AbstractCancer is one of the most devastating diseases that the world is currently facing, accounting for 10 million deaths in 2020 (WHO). In the last two decades, advanced medical imaging has played an ever more important role in the early detection of the disease, as it increases the chances of survival and the potential for full recovery. To date, dynamic glucose-enhanced (DGE) MRI using glucose-based chemical exchange saturation transfer (glucoCEST) has demonstrated the sensitivity to detect both d-glucose and glucose analogs, such as 3-oxy-methyl-d-glucose (3OMG) uptake in tumors. As one

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4

Kim, Mina, Francisco Torrealdea, Sola Adeleke, et al. "Challenges in glucoCEST MR body imaging at 3 Tesla." Quantitative Imaging in Medicine and Surgery 9, no. 10 (2019): 1628–40. http://dx.doi.org/10.21037/qims.2019.10.05.

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5

Nasrallah, Fatima A., Guilhem Pagès, Philip W. Kuchel, Xavier Golay, and Kai-Hsiang Chuang. "Imaging Brain Deoxyglucose Uptake and Metabolism by Glucocest MRI." Journal of Cerebral Blood Flow & Metabolism 33, no. 8 (2013): 1270–78. http://dx.doi.org/10.1038/jcbfm.2013.79.

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2-Deoxy-D-glucose (2DG) is a known surrogate molecule that is useful for inferring glucose uptake and metabolism. Although 13C-labeled 2DG can be detected by nuclear magnetic resonance (NMR), its low sensitivity for detection prohibits imaging to be performed. Using chemical exchange saturation transfer (CEST) as a signal-amplification mechanism, 2DG and the phosphorylated 2DG-6-phosphate (2DG6P) can be indirectly detected in 1H magnetic resonance imaging (MRI). We showed that the CEST signal changed with 2DG concentration, and was reduced by suppressing cerebral metabolism with increased gene

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6

Kentrup, Dominik, Annika Busch, Helga Pawelski, Eberhard Schlatter, Verena Hoerr, and Stefan Reuter. "SP772NON-INVASIVE DETECTION OF ACUTE RENAL ALLOGRAFT REJECTION THROUGH GLUCOCEST MRI." Nephrology Dialysis Transplantation 30, suppl_3 (2015): iii632. http://dx.doi.org/10.1093/ndt/gfv201.05.

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7

Colgan, Niall, Matthew Donoghue, Zdzislaw Zuchora, Brendan Tuohy, and Wil van der Putten. "Investigation of GlucoCEST as novel clinical MR biomarker of glucose metabolism." Physica Medica 32, no. 7 (2016): 959. http://dx.doi.org/10.1016/j.ejmp.2016.05.048.

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8

Xu, Xiang, Jiadi Xu, Kannie W. Y. Chan, et al. "GlucoCEST imaging with on-resonance variable delay multiple pulse (onVDMP) MRI." Magnetic Resonance in Medicine 81, no. 1 (2018): 47–56. http://dx.doi.org/10.1002/mrm.27364.

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9

Kentrup, Dominik, Philipp Bovenkamp, Annika Busch, et al. "GlucoCEST magnetic resonance imaging in vivo may be diagnostic of acute renal allograft rejection." Kidney International 92, no. 3 (2017): 757–64. http://dx.doi.org/10.1016/j.kint.2017.04.015.

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10

Xu, Xiang, Jiadi Xu, Linda Knutsson, et al. "The effect of the mTOR inhibitor rapamycin on glucoCEST signal in a preclinical model of glioblastoma." Magnetic Resonance in Medicine 81, no. 6 (2019): 3798–807. http://dx.doi.org/10.1002/mrm.27683.

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11

Xu, Xiang, Akansha Ashvani Sehgal, Nirbhay N. Yadav, et al. "d ‐glucose weighted chemical exchange saturation transfer (glucoCEST)‐based dynamic glucose enhanced (DGE) MRI at 3T: early experience in healthy volunteers and brain tumor patients." Magnetic Resonance in Medicine 84, no. 1 (2019): 247–62. http://dx.doi.org/10.1002/mrm.28124.

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12

Pudrith, Charles, Timothy T. K. Jung, You Hyun Kim, et al. "SP338 – Treatment of LPS-induced otitis media with various glucocort." Otolaryngology - Head and Neck Surgery 141, no. 3 (2009): P199. http://dx.doi.org/10.1016/j.otohns.2009.06.638.

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13

Mulyanti, Budi, Lilik Hasanah, Tommi Hariyadi, et al. "The Influence of Glucose Concentration to Resonant Wavelength Shift of Polymer-Based Microring Resonators." Advanced Materials Research 1112 (July 2015): 32–36. http://dx.doi.org/10.4028/www.scientific.net/amr.1112.32.

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Microring resonators (MRRs) is a compact and multi-functioned device which is mainly characterized by free spectral range (FSR) and quality factor (Q-factor). In this paper, the influence of glucose concentration to the resonant wavelength shift of MRRs is presented. The calculation was carried out using semi-numerical method for different values of FSR and Q-factor. The parameters used in the calculation including incident wavelength, ring radii of circular waveguide, gap sizes between circular and straight waveguides, the dimension of both waveguides, and refractive index of polymer, SiO2 an

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14

AKAGIĆ, Asima, Amila VRANAC, Fuad GAŠI, et al. "Sugars, acids and polyphenols profile of commercial and traditional apple cultivars for processing." Acta agriculturae Slovenica 113, no. 2 (2019): 239. http://dx.doi.org/10.14720/aas.2019.113.2.5.

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Three commercial apple cultivars ('Jonagold', 'Granny Smith' and 'Idared') and the local apple cultivar ('Prijedorska Zelenika') from Bosnia and Herzegovina were analysed by HPLC-MS for the content of phenolic compounds in peel and pulp as well content of individual sugars and organic acids. Catechin, (-)-epicatechin, chlorogenic acid, caffeic acid, quercetin 3-<em>O</em>-xyloside, quercetin 3-<em>O</em>-arabinoside, quercetin 3-<em>O</em>-rhamnoside, quercetin 3-<em>O</em>-rutinoside, quercetin 3-<em>O</em>-galactoside and quercetin

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15

Henny, Kasmawati* Ruslin Sunandar Ihsan Hasnawati Suryani Brigita Anugrah Pertama Sinar Ayu Farida. "ANTIDIABETIC ACTIVITY OF ETHANOL EXTRACT OF SONI LEAVES (DILLENIA CELEBICA HOOGLAND.) ON BLOOD GLUCOSE LEVELS AND PANCREATIC HISTOLOGY OF MALE WISTAR RATS GLUCOSE-INDUCED." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 07 (2019): 13649–59. https://doi.org/10.5281/zenodo.3346991.

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<strong><em>Objective:</em></strong><em> Determine the potential, effectiveness and histology of pancreatic organs of wistar male rats with type II diabetes after glucose induction by giving ethanol extract of soni leaves </em><em>(</em><em>Dillenia</em> <em>celebica</em> <em>Hoogland</em><em>.)</em><em>. </em> <strong><em>Method:</em></strong><em> Experimental with pre-post test randomized control group design. One-Way Anova Statistics to see a decrease and percent decrease in blood glucose levels. The histology of the pancreatic organs is based the number of endocrine cells the islet of Lang

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16

Jesus Magueta, S., A. L. Costa, G. Simões, A. I. Gomes, C. Madaíl Grego, and P. Garrido. "Hormones and Psychosis: The Role of Estrogen in Schizophrenia." European Psychiatry 67, S1 (2024): S175—S176. http://dx.doi.org/10.1192/j.eurpsy.2024.386.

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IntroductionSchizophrenia is a complex psychiatric disorder in which biological sex differences, have been extensively documented and researched. What is less well described, is what motivates these differences. Of the various proposed and explored reasons, estrogen appears to be one that has maintained some interest and promise. An increase in symptoms of schizophrenia has been observed to correspond with decreasing levels of estrogen in menopausal women, this, allied to the later symptom onset, culminated in the interest in this hormone and its role in psychotic illness.ObjectivesThe authors

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17

Chen, Peidong, Zhiwei Shen, Qianqian Wang, et al. "Reduced Cerebral Glucose Uptake in an Alzheimer’s Rat Model With Glucose-Weighted Chemical Exchange Saturation Transfer Imaging." Frontiers in Aging Neuroscience 13 (March 17, 2021). http://dx.doi.org/10.3389/fnagi.2021.618690.

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A correlation between the abnormal cerebral glucose metabolism and the progression of Alzheimer’s disease (AD) has been found in previous studies, suggesting that glucose alterations may be used to predict the histopathological diagnosis in AD. In this study, we investigated the dynamic changes of cerebral glucose uptake in vivo using MR glucose chemical exchange saturation transfer (glucoCEST) imaging in a rat model of AD with an intracerebroventricular (i.c.v) injection of amyloid Aβ-protein (25–35), confirmed by Morris water maze and Nissl staining. In total, 6 rats in the AD group and 6 ra

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18

Schache, Daniel, Ajay Peddi, Ali Nahardani, Cornelius Faber, and Verena Hoerr. "Corrections for Rabi oscillations in cardiac chemical exchange saturation transfer MRI under the influence of very short preparation pulses." NMR in Biomedicine, December 19, 2023. http://dx.doi.org/10.1002/nbm.5081.

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AbstractVery short chemical exchange saturation transfer (CEST) pulses are beneficial in cardiac continuous wave (cw) CEST MRI, especially in small animals because of their rapid heartbeat; however, they result in signal modulations caused by Rabi oscillations. Therefore, we implemented two different filter techniques, DOwnsampling by SEparation of CEST spectrum into two parts (DOSE) and time domain (TD)‐based filtering, to correct for these signal corruptions, allowing a reliable quantification of glucose‐weighted CEST (glucoCEST) MRI contrast. In our study, cw CEST measurements were performe

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19

Meng, Nan, Zhun Huang, Han Jiang, et al. "Glucose chemical exchange saturation transfer MRI for predicting the histological grade of rectal cancer: a comparative study with amide proton transfer-weighted and diffusion-weighted imaging." Insights into Imaging 15, no. 1 (2024). http://dx.doi.org/10.1186/s13244-024-01828-z.

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Abstract Background To evaluate the utility of glucose chemical exchange saturation transfer (glucoCEST) MRI with non-contrast injection in predicting the histological grade of rectal cancer. Methods This prospective analysis included 60 patients with preoperative rectal cancer who underwent pelvic glucoCEST, amide proton transfer-weighted imaging (APTWI), and diffusion-weighted imaging (DWI). In total, 21 low-grade and 39 high-grade cases were confirmed by postoperative pathology. The MTRasym (1.2 ppm), MTRasym (3.5 ppm), and apparent diffusion coefficient (ADC) values of lesions between the

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20

"Glucose chemical exchange saturation transfer (glucoCEST) to image enhanced glucose uptake in tumor tissues." Science-Business eXchange 6, no. 30 (2013): 809. http://dx.doi.org/10.1038/scibx.2013.809.

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21

Wu, Yulun, Sophie H. A. E. Derks, Tobias C. Wood, et al. "Improved postprocessing of dynamic glucose-enhanced CEST MRI for imaging brain metastases at 3 T." European Radiology Experimental 7, no. 1 (2023). http://dx.doi.org/10.1186/s41747-023-00390-5.

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Abstract Background Dynamic glucose-enhanced (DGE) chemical exchange saturation transfer (CEST) has the potential to characterize glucose metabolism in brain metastases. Since the effect size of DGE CEST is small at 3 T (< 1%), measurements of signal-to-noise ratios are challenging. To improve DGE detection, we developed an acquisition pipeline and extended image analysis for DGE CEST on a hybrid 3-T positron emission tomography/magnetic resonance imaging system. Methods This cross-sectional study was conducted after local ethical approval. Static Z-spectra (from -100 to 100 ppm) were acqui

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22

Zaiss, Moritz, Annasofia Anemone, Steffen Goerke, et al. "Quantification of hydroxyl exchange of D‐Glucose at physiological conditions for optimization of glucoCEST MRI at 3, 7 and 9.4 Tesla." NMR in Biomedicine 32, no. 9 (2019). http://dx.doi.org/10.1002/nbm.4113.

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23

"Arterial Input Functions and Tissue Response Curves in Dynamic Glucose-Enhanced (DGE) Imaging: Comparison Between glucoCEST and Blood Glucose Sampling in Humans." Tomography 4, no. 4 (2018): 164–71. http://dx.doi.org/10.18383/j.tom.2018.00025.

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24

Capozza, Martina, Annasofia Anemone, Chetan Dhakan, et al. "GlucoCEST MRI for the Evaluation Response to Chemotherapeutic and Metabolic Treatments in a Murine Triple-Negative Breast Cancer: A Comparison with[18F]F-FDG-PET." Molecular Imaging and Biology, August 12, 2021. http://dx.doi.org/10.1007/s11307-021-01637-6.

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25

Dickie, Ben R., Tao Jin, Ping Wang, et al. "Quantitative kinetic modelling and mapping of cerebral glucose transport and metabolism using glucoCESL MRI." Journal of Cerebral Blood Flow & Metabolism, June 23, 2022, 0271678X2211088. http://dx.doi.org/10.1177/0271678x221108841.

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Chemical-exchange spin-lock (CESL) MRI can map regional uptake and utilisation of glucose in the brain at high spatial resolution (i.e sub 0.2 mm3 voxels). We propose two quantitative kinetic models to describe glucose-induced changes in tissue R1ρ and apply them to glucoCESL MRI data acquired in tumour-bearing and healthy rats. When assuming glucose transport is saturable, the maximal transport capacity ( Tmax) measured in normal tissue was 3.2 ± 0.6 µmol/min/mL, the half saturation constant ( Kt) was 8.8 ± 2.2 mM, the metabolic rate of glucose consumption ( MRglc) was 0.21 ± 0.13 µmol/min/mL

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26

Vifta, Rissa, Wilantika Wilantika, and Yustisia Dian Advistasari. "STUDI IN VITRO POTENSI ANTIOKSIDAN DAN AKTIFITAS ANTIDIABETES FRAKSI ETIL ASETAT BUAH PARIJOTO (Medinilla speciosa B.)." Jurnal Tumbuhan Obat Indonesia 12, no. 2 (2019). http://dx.doi.org/10.22435/jtoi.v12i2.1160.

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ABSTRACT Parijoto fruit (Medinilla speciosa B) contains the flavonoid which is one of the phenolic groups compounnd. Flavonoids has biological activities as anti free radical and antionxidants. The aim of this research was to evaluate the potency of ethyl acetat fraction of M.speciosa B. Extract as an antioxidants and antidiabetic. Evaluation of antioxidants activity was carried out by in vitro assay using the ABTS method (2.2 azinobis (3-ethylbenzotiazolin) -6-sulfonic acid), while the antidiabetic assay was carried out using the Nelson-Somogyi method. Research begins with the process o

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