Journal articles: 'Glues'

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Mamoňová, Miroslava, Dávid Ciglian, and Ladislav Reinprecht. "SEM Analysis of Glued Joints of Thermally Modified Wood Bonded with PUR and PVAc Glues." Materials 15, no. 18 (September 16, 2022): 6440. http://dx.doi.org/10.3390/ma15186440.

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This study deals with the scanning electron microscopy (SEM) analyses of the phase interfaces in the glued joints between Norway spruce wood elements thermally modified at 160, 180, 200, and 220 °C/4 h and polyurethane (PUR) and polyvinyl acetate (PVAc) glues with the aim of evaluating various anatomical influences of wood on the quality of joints. Due to cracked regions created in the surface of spruce wood at severe thermal modifications, the penetration depth of glues doubled from 140 to 241 μm for PUR glue, and from 100 to 200 μm for PVAc glue. The thickness of glue lines in joints was apparently higher for PVAc glue, mainly in earlywood regions; however, in joints from thermally modified (TM) woods it increased more apparently for PUR glue from 16.6 to 44.4 μm, probably in connection with formation of micro-bubbles in its structure. The SEM analyses corresponded well with the previous knowledge about lower shear strength of glued joints formed from the more intensively TM spruce elements and mentioned types of glues.

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Laiveniece, Laura, and Andris Morozovs. "Impact of Water on Rheological Behavior of Polyurethane Glues." Rural Sustainability Research 35, no. 330 (June 1, 2016): 7–18. http://dx.doi.org/10.1515/plua-2016-0002.

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Abstract Gluing of wood with great moisture content has challenge of water interaction with glue to give unwanted changes in glue properties and formed bond-line. Rheological measurements of polyurethane glues are sufficiently effective method to understand the polymer curing process and viscoelastic properties. Gel formation point is important parameter for a glue from the point of its application. When glue reaches the gel formation point, its viscosity drastically increases so that it could not properly wet the wood and it can result in poor bonds. One-component moisture curing polyurethane glues require water molecules for the polyadditional reaction. When water is involved in the curing reaction, it reacts with the isocyanate groups of glue and can lead to the formation of excessive carbon dioxide and thus can lead to glue penetration out of bond-line, additional backpressure. The dynamic viscoelastic parameters such as complex dynamic viscosity (ή), phase angle (δ), elastic storage modulus (G”), the viscous loss modulus (G”) of two kinds of polyurethane glues depending on added water amount (from 0.9% to 10.0%) at a constant frequency and deformation (oscillation mode) were determined using rheometer. The aim of the present study was to investigate impact of added water on rheological behavior of polyurethane glues. At the end of this study it was concluded that tested glues indicated various behavior depending on chemical composition and added water content. Gel formation point is higher in case of GlueI. However, gel formation time was higher in case of GlueII and was not dependent on added water content. Gel formation time was faster for GlueII. Nevertheless, faster formed gel is stronger than longer formed gel of GlueI.

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Isaev, A. Yu, E. V. Rubtsova, E. V. Kotova, and M. N. Sutyagin. "RESEARCH OF PROPERTIES OF GLUES AND GLUE BINDING, MADE WITH USE OF MODERN DOMESTIC COMPONENT BASE." Proceedings of VIAM, no. 3 (2021): 58–67. http://dx.doi.org/10.18577/2307-6046-2021-0-3-58-67.

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Properties of epoxy glues of cold curing VK-9 and VKV-9, the components received with use which are let out by modern producers, depending on the filler used in their structure are considered. Tests of glued joints on VK-9 glue in wider interval of temperatures are carried out. Properties of VK-36 glue and its updating’s on the basis of components let out now are shown. Properties of glue binding brands VSK-14-1, VSK-14-2, VSK-14-4, VSK-14-4m and VSK-14-4k received, under production conditions by VIAM Federal State Unitary Enterprise are given. It is shown that on the properties they completely meet the requirements of existing normative documentation.

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Li, Yongjiang, Lei Xiao, Zian Wang, Kejie Chen, Chundong Xue, Miao Yu, Yu Wang, Fanyi Kong, Kun Liu, and Kairong Qin. "Raman Spectroscopic Characterization of Polymerization Kinetics of Cyanoacrylate Embolic Glues for Vascular Embolization." Polymers 13, no. 19 (September 30, 2021): 3362. http://dx.doi.org/10.3390/polym13193362.

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Endovascular glue embolization is a minimally invasive technique used to selectively reduce or block the blood supply to specific targeted vessels. Cyanoacrylate glues, mixed with radiopaque iodized oil, have been widely used for vascular embolization owing to their rapid polymerization rate, good penetration ability and low tissue toxicity. Nevertheless, in clinical practice, the selection of the glue–oil proportion and the manual injection process of mixtures are mostly based on empirical knowledge of operators, as the crucial physicochemical effect of polymerization kinetics has rarely been quantitatively investigated. In this study, the Raman spectroscopy is used for studying the polymerization kinetics of n-butyl-cyanoacrylate-based glues mixed with an iodized oil. To simulate the polymerization process during embolization, glue–oil mixtures upon contact with a protein ionic solution mimicking blood plasma are manually constructed and their polymerization kinetics are systematically characterized by Raman spectroscopy. The results demonstrate the feasibility of Raman spectroscopy in the characterization of polymerization kinetics of cyanoacrylate-based embolic glues. The polymerization process of cyanoacrylate-based mixtures consists of a fast polymerization phase followed by a slow phase. The propagation velocity and polymerization time primarily depend on the glue concentrations. The commonly used 50% mixture polymerizes 1 mm over ∼21.8 s, while it takes ∼51 min to extend to 5 mm. The results provide essential information for interventional radiologists to help them understand the polymerization kinetics of embolic glues and thus regulate the polymerization rate for effective embolization.

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Devaud, Yannick R., Senta Stäuble, Ueli Moehrlen, Miriam Weisskopf, Ladina Vonzun, Roland Zimmermann, Martin Ehrbar, and Nicole Ochsenbein-Kölble. "Minimally Invasive Precise Application of Bioadhesives to Prevent IPPROM on a Pregnant Sheep Model." Fetal Diagnosis and Therapy 48, no. 11-12 (2021): 785–93. http://dx.doi.org/10.1159/000519910.

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Introduction: Iatrogenic preterm premature rupture of the membrane remains the Achille’s heel of fetoscopy. The aim of this study was to show in vivo feasibility of fetal membrane (FM) defect sealing by the application of tissue glues with umbrella-shaped receptors. Methods: First, we adapted our previously described ex vivo strategy and evaluated the adhesion strength of different tissue glues, Histoacryl® and Glubran2®, by bonding polytetrafluoroethylene or silicone encapsulated nitinol glue receptor to human FM. Then, we exposed pregnant sheep uterus through a laparotomy and placed a 10-French trocar into the amniotic cavity through which the umbrella-shaped glue receptor (n = 9) was inserted and fixated onto the FM with the tissue glues (n = 8). The tightness of the sealed defects was assessed 4 h post-surgery. Results: Both tissue glues tested resulted in adhesion of the glue receptors to the FM ex vivo. In vivo, all glue receptors opened in the amniotic cavity (n = 9) and all successfully placed glue receptors sealed the FM defect (n = 8). Four hours post-surgery, 2 treatment sites showed minimal leakage whereas the negative control without glue (n = 1) showed substantial leakage. Discussion: This in vivo study confirms that fetoscopically induced FM defects can be sealed by the application of tissue adhesives.

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Zhang, Yujia, Jessica Bates, Benoit Gourdet, Louise Birch, Philip Addis, Roland Hjerpe, and Allan M. Jordan. "Abstract 3429: Beyond cereblon IMIDs - biophysics-based discovery of novel molecular glue chemotypes." Cancer Research 83, no. 7_Supplement (April 4, 2023): 3429. http://dx.doi.org/10.1158/1538-7445.am2023-3429.

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Abstract Molecular glue degraders are compact, low molecular weight molecules that can efficiently induce specific and potent degradation of a target protein. This class of degraders function by inducing interactions between a target of interest and a ubiquitin-ligase, either by stabilization of weak pre-existing interactions, or by generation of entirely novel interactions. These molecules offer significant opportunity beyond heterobifunctional degraders such as PROTACs, not least in terms of improved molecular properties. However, beyond the IMID molecular glues, typified by thalidomide, pomalidomide and lenalidomide, novel molecular glue chemotypes remain scarce. To address this need, we have developed biophysics-based molecular glue screening platform, exploiting our internal, high quality fragment library and proximity-based screening platforms to rapidly identify promising new molecular glues for further optimization. A potential advantage of utilizing cell-free biophysical systems is the opportunity to select both the target and the desired ligase, opening up for development of degraders that capitalize upon differential expression of ligases in different tissues. As proof of concept, we have applied this platform to find new molecular glues to degrade CK1α. This Ser/Thr kinase has been found to be over-expressed in metastatic colorectal cancer, and this over-expression correlates with poor overall survival. The kinase has also been implicated as an oncogenic driver in tumors such as B-Cell lymphomas and non-Hodgkin lymphomas, suggesting a potential therapeutic application for novel CK1α molecular glues. Utilizing known IMID-derived molecular glues between CK1α and CRBN as benchmark controls, we identified several non-IMID derived chemotypes as tentative stabilizers of the CRBN/CK1α interaction. Further studies on these novel candidate degrader templates are now underway. Citation Format: Yujia Zhang, Jessica Bates, Benoit Gourdet, Louise Birch, Philip Addis, Roland Hjerpe, Allan M. Jordan. Beyond cereblon IMIDs - biophysics-based discovery of novel molecular glue chemotypes [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3429.

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Rule, Kirrily C., Richard A. Mole, and Dehong Yu. "Which glue to choose? A neutron scattering study of various adhesive materials and their effect on background scattering." Journal of Applied Crystallography 51, no. 6 (November 22, 2018): 1766–72. http://dx.doi.org/10.1107/s1600576718014930.

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The background scattering from numerous frequently used sample adhesives has been investigated to determine the background contribution of these glues when used for inelastic neutron scattering measurements. Starting with a bare Cu sheet, different glues have been trialled, such as GE varnish, CYTOP solution, Teflon tape, Fomblin oil and two-component epoxy glue. Measurements were collected using the PELICAN cold-neutron time-of-flight spectrometer at ANSTO, which is capable of collecting data over a wide range of Q–ω space simultaneously. The results indicate that those glues containing hydrogen give much higher background signals, while those that do not contain hydrogen have a much smaller impact on the background signal. This was observed for both elastic and inelastic neutron scattering.

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Yildrim, Mehmet Nuri, Abdurrahman Karaman, and Mustafa Zor. "Bending Characteristics of Laminated Wood Composites Made of Poplar Wood and GFRP." Drvna industrija 72, no. 1 (February 11, 2021): 3–11. http://dx.doi.org/10.5552/drvind.2021.1913.

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In this study, 4 layers of 5 mm thick slats obtained by sawing method from poplar wood were used. Plain woven GRFP with low density and grammage of 100 g/m2 (Type 1) and plain woven GRFP with high density and grammage of 200 g/m2 (Type 2) were placed and glued between each layer. Polyvinyl acetate (PVAc-D4), Polyurethane (PU) and dual-component Epoxy (L285-resin and H285-hardener) adhesives were used for gluing the layers. Strength values (bending and modulus of elasticity) between the obtained layers were investigated. As a result of the study, it was determined that epoxy glue has higher strength than polyurethane and polyvinyl acetate glues; Type 2 plain woven fabric has higher strength than Type 1 plain woven fabric; and parallel load to the glue line results in higher performance than perpendicular load to the glue line.

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Argoud, R., and J. Muller. "Effect of stress from the glue on single-crystal X-ray intensities at high or low temperatures." Journal of Applied Crystallography 22, no. 4 (August 1, 1989): 378–80. http://dx.doi.org/10.1107/s0021889889004206.

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For high- or low-temperature single-crystal X-ray data collection, the glues used to bind crystals to silica rods may induce strong modifications of the intensities. When an yttrium iron garnet (YIG) crystal was cooled, reflections which were equivalent at room temperature became different. This is explained by strong stresses of the glue on the crystal which lead to an anisotropic modification of the secondary extinction. At low temperatures, `glues' such as beeswax or paraffin do not exert stresses.

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Mirzaei, Yalda, Kerstin Hagemeister, Martina Hüffel, Timo Schwandt, René H. Tolba, and Julia Steitz. "A Novel In Vitro Method to Assess the Microbial Barrier Function of Tissue Adhesives Using Bioluminescence Imaging Technique." BioMed Research International 2022 (January 10, 2022): 1–10. http://dx.doi.org/10.1155/2022/3483238.

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Background. Tissue glues can minimize treatment invasiveness, mitigate the risk of infection, and reduce surgery time; ergo, they have been developed and used in surgical procedures as wound closure devices beside sutures, staples, and metallic grafts. Regardless of their structure or function, tissue glues should show an acceptable microbial barrier function before being used in humans. This study proposes a novel in vitro method using Escherichia coli Lux and bioluminescence imaging technique to assess the microbial barrier function of tissue glues. Different volumes and concentrations of E. coli Lux were applied to precured or cured polyurethane-based tissue glue placed on agar plates. Plates were cultured for 1 h, 24 h, 48 h, and 72 h with bioluminescence signal measurement subsequently. Herein, protocol established a volume of 5 μL of a 1 : 100 dilution of E. coli Lux containing around 2 × 10 7 CFU/mL as optimal for testing polyurethane-based tissue glue. Measurement of OD600nm, determination of CFU/mL, and correlation with the bioluminescence measurement in p/s unit resulted in a good correlation between CFU/mL and p/s and demonstrated good reproducibility of our method. In addition, this in vitro method could show that the tested polyurethane-based tissue glue can provide a reasonable barrier against the microbial penetration and act as a bacterial barrier for up to 48 h with no penetration and up to 72 h with a low level of penetration through the material. Overall, we have established a novel, sensitive, and reproducible in vitro method using the bioluminescence imaging technique for testing the microbial barrier function of new tissue glues.

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Temnikova, Elena Yu, Alexey A. Lapin, and Alexander R. Bogomolov. "The optimal composition of reagents for producing aluminosilicate glue based on fly ash of thermal power plants." EPJ Web of Conferences 196 (2019): 00014. http://dx.doi.org/10.1051/epjconf/201919600014.

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The work is devoted to the processing of fly ash wastes obtained from coal combustion. Based on the non-magnetic fraction of fly ash (its particle size of 0-50 μm), an aluminosilicate glue or liquid glass as a cementing component has been obtained. It was represented by a number of silicate modules (SiO2/Me2O molar ratios): 2, 2.5 and 3 (for three different formulations). The shear deformation tests for glued plates with glues of various silicate modules have been carried out. The shear stresses for the samples with silicate modules of 2.0, 2.5, 3.0 were equal to 48, 66 and 34 kPa, respectively. These results suggest that during the production of aluminosilicate glue, the silicate module of 2.5 is more favored for providing the strongest bond between ceramic tiles.

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de Lima, Douglas Mateus, Humberto Correia Lima Júnior, and Iálysson da Silva Medeiros. "Physical and mechanical properties of glued laminated bamboo." BioResources 18, no. 2 (April 3, 2023): 3522–39. http://dx.doi.org/10.15376/biores.18.2.3522-3539.

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Certain bamboo species have mechanical properties that are compatible with construction material. Despite this, their low shear strength, the presence of nodes in their culms, and their circular geometry inhibit the expansion of the use of this material as construction material. One technique that can solve these problems is glued laminated bamboo (GLB). Based on such findings, this paper aims to evaluate the physical and mechanical properties of glued laminated bamboo of the Dendrocalamus giganteus species. Two glues were used: resorcinol-formaldehyde (PRF) and polyvinyl acetate (PVAc). The following physical and mechanical characterization tests were performed on glued laminated bamboo: water absorption, density, compression parallel to fiber direction, tension parallel to fiber direction, shear parallel to the glue layer, shear parallel to fiber direction, and bending. The results, analyzed using statistical models, showed that the GLB has physical and mechanical properties comparable to those of hardwoods.

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Tarasenko, O. M., and V. I. Zaborovskyi. "Application of Biological Glue in Orthopedics and Traumatology." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 6, no. 5 (October 27, 2021): 51–55. http://dx.doi.org/10.26693/jmbs06.05.051.

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The purpose of the study was to investigate the method of osteosynthesis using glues. Materials and methods. The simplest and most effective method in the treatment of traumatological patients is a plaster fixing bandage of different variations. This is a conservative type of treatment. Also, a very common method in the treatment of orthopedic and traumatological patients is the surgical method. Modern high-tech methods of osteosynthesis require a thorough preoperative examination of the patient, conducting a 3D tomographic examination for intra-articular fractures, clear planning of the course of surgical intervention, electro optical probing techniques during the operation, the availability of tool kits for installing retainers, the ability to choose a retainer intraoperative in the size range. An orthopedic-traumatologist and the entire operating team need appropriate training. All operational fixation methods must provide adequate stability to maintain axis length and rotation. Results and discussion. In the world practice, biological glues are used in such areas as abdominal surgery, neuro- and cardiac surgery, plastic and pediatric surgery, orthopedics and traumatology. Cyanocrylate glues have undergone extensive experimental clinical testing. Positive characteristics of cyanoacrylate glues are the ability to glue living tissues in a humid environment, polymerization rate, autosterility, bactericidal, absence of histotoxicity, hemostatic effect. Another glue in the review is sulfacrylate. It can be used in patients of any age, starting from newborns, regardless of the pathogenesis of the disease. Venaseal glue, used by many authors to treat fistulas of the gastrointestinal tract. Widely used fibrin glues, such as Evicel, are used to achieve hemostasis and sealing in surgery, for example, in vascular operations, kidney resection and neurosurgical interventions, in the surgical treatment of distal hypospadias in children. BioGlue glue is designed to seal surgical sutures, thereby preventing fluids (exudate, lymph, urine, gastric juice) and / or air from leaking through them. It is also used in liver surgery. At the moment, the use of bone cement is the most common auxiliary method for surgical interventions. But its side effects are very clear. Bone cement can cause the patient to die on the operating table or, in the postoperative period, in intensive care. This is due to an immediate or rapid allergic reaction. This situation is dangerous for humans. Biological glues are not so toxic and do not cause such allergic reactions Conclusion. The search for new materials and techniques for consolidating bone fragments is one of the most important problems of modern medical science, namely orthopedics and traumatology. Substances that are included in the biological glue must be bioinert, contain elements of strength (for holding fragments), looseness of the structure (for germination of capillaries between fragments), natural antibiotic (for antibiotic prevention), activators of hematopoiesis processes (for the fastest callus), organic and inorganic substances (for the building material of bone tissue). Therefore, the desire to improve treatment and improve its results, in particular in orthopedics and traumatology, is the key to the development of modern medicine

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Dayyoub, Tarek, Aleksey Maksimkin, Fedor Senatov, Sergey Kaloshkin, Natalia Anisimova, and Mikhail Kiselevskiy. "A New Approach Based on Glued Multi-Ultra High Molecular Weight Polyethylene Forms to Fabricate Bone Replacement Products." Polymers 12, no. 11 (October 30, 2020): 2545. http://dx.doi.org/10.3390/polym12112545.

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Three types of glue based on thiol-ene reaction, polyvinyl alcohol (PVA)/cellulose, and phenol formaldehyde were prepared and applied on modified ultra-high molecular weight polyethylene (UHMWPE) samples grafted by cellulose. In comparison with unmodified UHMWPE samples, T-peel tests on the modified and grafted UHMWPE films showed an increase in the peel strength values for the glues based on thiol-ene reaction, PVA/cellulose, and phenol formaldehyde by 40, 29, and 41 times, respectively. The maximum peel strength value of 0.62 Kg/cm was obtained for the glue based on phenol formaldehyde. Mechanical tests for the cylindrical multi-UHMWPE forms samples, made of porous UHMWPE as a trabecular layer and an armored layer (cortical layer) that consists of bulk and UHMWPE films, indicated an improvement in the mechanical properties of these samples for all glue types, as a result of the UHMWPE films existence and the increase in the number of their layers. The maximum compressive yield strength and compressive modulus values for the armored layer (bulk and six layers of the UHMWPE films using the glue based on thiol-ene reaction) were 44.1 MPa (an increase of 17%) and 1130 MPa (an increase of 36%), respectively, in comparison with one armored layer of bulk UHMWPE. A hemocompatibility test carried out on these glues clarified that the modified UHMWPE grafted by cellulose with glues based on PVA/cellulose and thiol-ene reaction were classified as biocompatible materials. These multi-UHMWPE forms composites can be considered a promising development for joint reconstruction.

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Munjal, Manish, Shubham Munjal, Saloni Sharma, Vineeta Arora, Hardeep Kaur, Deeksha Chawla, Loveleen Sandhu, Dhruv Gupta, and Ruchika Gill. "‘Glues’-the basics and practical applicability in oto-rhino-laryngology and head neck surgery: a review." International Journal of Otorhinolaryngology and Head and Neck Surgery 8, no. 10 (September 26, 2022): 865. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20222452.

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Glues or tissue adhesives have attained a foothold in the arena of otorhinolaryngology.and skull base-head neck surgery. At the sites inaccessible to time tested suture application, they facilitate tissue synthesis and local haemostasis, excellent adhesion, elastic consistency, tissue compatibility, and ability to disintegrate and thereby get completely absorbed with time are the properties of an ideal glue tympanoplasty, ossiculoplasty. CSF leak repair are the widely used applications of this suture less modality. Biological and synthetic glues have been developed. The former being the fibrin glues (1940) and the latter, the cyanoacrylates (1960). Moreover in addition to adequate wound closure, a secure fixation of skin grafts, transplants and implants is vital for the success of a surgical intervention. At these crucial sites, tissue adhesives are the preferred option.

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Inghilleri, Giovanni, and Francesco Mercuriali. "Surgical Glues." Transfusion Alternatives in Transfusion Medicine 4, s2 (April 2002): 36–37. http://dx.doi.org/10.1111/j.1778-428x.2002.tb00269.x.

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Bachtiar, Erik V., Gaspard Clerc, Andreas J. Brunner, Michael Kaliske, and Peter Niemz. "Static and dynamic tensile shear test of glued lap wooden joint with four different types of adhesives." Holzforschung 71, no. 5 (May 1, 2017): 391–96. http://dx.doi.org/10.1515/hf-2016-0154.

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Abstract Investigations of quasi-static and fatigue failure in glued wooden joints subjected to tensile shear loading are presented. Lap joints of beech wood (Fagus sylvatica L.) connected with four different types of adhesives, i.e. polyurethane (PUR), melamine urea formaldehyde (MUF), bone glue and fish glue, were experimentally tested until the specimens failed. The average shear strengths obtained from the quasi-static test ranged from 12.2 to 13.4 MPa. These results do not indicate any influence of the different adhesive types. The influence of the adhesives is only visible from the results of the fatigue tests, which were carried out under different stress excitation levels between 45% and 75% of the shear strength. Specimens bound with ductile adhesive (PUR) showed a slightly higher number of cycles to failure (Nf) at low-stress levels and lower Nf at high-stress levels in comparison to more brittle adhesives (MUF, fish glue). In general, the performances of animal glues and MUF were similar in both quasi-static and fatigue loading under dry conditions.

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Schwarzenbrunner, Ronald, Marius Catalin Barbu, Alexander Petutschnigg, and Eugenia Mariana Tudor. "Water-Resistant Casein-Based Adhesives for Veneer Bonding in Biodegradable Ski Cores." Polymers 12, no. 8 (August 5, 2020): 1745. http://dx.doi.org/10.3390/polym12081745.

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The aim of this study is to investigate the performance of casein-based adhesives for the bonding of ash (Fraxinus spp.) veneers for the manufacture of biodegradable skis. Different formulations containing casein powder, water, lime, sodium silicate, and various glue amounts were tested for shear strength after water storage, modulus of rupture and modulus of elasticity, water absorption, and thickness swelling. Two other classic wood adhesives, namely epoxy and polyvinyl acetate (PVAc) type D4 were used as control. The highest efficiency of both mechanical and physical properties was recorded for the samples glued with caseins and an increased amount of lime. There was also an affinity between casein adhesive distribution and physical and mechanical plywood performance. Moreover, the developed casein-based glues were also used to bond the plywood for ski cores and tested in real-life winter conditions.

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Andreev, Vladimir I., and Robert A. Turusov. "Thermal Strength of Adhesion Bond." Applied Mechanics and Materials 670-671 (October 2014): 153–57. http://dx.doi.org/10.4028/www.scientific.net/amm.670-671.153.

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The article considers the one-dimensional problem of the destruction of the simplest model of adhesively engage consisting generally of the many plates, which are substrates (what are glued) and adhesives (glues). The ability of the model to resist to thermal impact without fracturing here conventionally called the thermal strength. The problem is solved in the elastic formulation.

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Valentini, Luca, Maria Rachele Ceccarini, Raquel Verdejo, Gianluca Tondi, and Tommaso Beccari. "Stretchable, Bio-Compatible, Antioxidant and Self-Powering Adhesives from Soluble Silk Fibroin and Vegetal Polyphenols Exfoliated Graphite." Nanomaterials 11, no. 9 (September 10, 2021): 2352. http://dx.doi.org/10.3390/nano11092352.

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The development of bio-glues is still a challenging task, regarding adhesion on wet surfaces; often, high performance and adaption to complex geometries need to be combined in one material. Here, we report biocompatible adhesives obtained by blending regenerated silk (RS) with a soluble plant-derived polyphenol (i.e., chestnut tannin) that was also used to exfoliate graphite to obtain graphene-based RS/tannin (G-RS/T) composites. The resultant G-RS/T hybrid material exhibited outstanding stretchability (i.e., 400%) and high shear strength (i.e., 180 kPa), superior to that of commercial bio-glues, and showed sealant properties for tissue approximation. Moreover, we showed how such nanocomposites exhibit electromechanical properties that could potentially be used for the realization of green and eco-friendly piezoelectric devices. Finally, we demonstrate the in vitro glue’s biocompatibility and anti-oxidant properties that enable their utilization in clinical applications.

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Stagon, Stephen, Alex Knapp, Paul Elliott, and Hanchen Huang. "Metallic Glue for Ambient Environments Making Strides." AM&P Technical Articles 174, no. 1 (January 1, 2016): 22–25. http://dx.doi.org/10.31399/asm.amp.2016-01.p022.

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Abstract Advancements in nanoscience are making it possible to metallically glue two solids together at room temperature, in air, and under a small amount of mechanical pressure. Metallic glues can serve as excellent conductors for heat dissipation and electrical current in electronic devices and also as leak-resistant seals for vacuum environments.

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Zolkiewski, Sławomir. "Testing of Fibreglass-Metal Laminates in Epoxy Warp Connected by Means of the Adhesive Layer." Solid State Phenomena 199 (March 2013): 599–604. http://dx.doi.org/10.4028/www.scientific.net/ssp.199.599.

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The fibre-metal laminate specimens were connected with steel plates by means of the glue joints. The influence of the type of connection on composite mechanical properties (displacement vs. force characteristics) was analyzed. The glue joint between the laminate and the steel plate guarantees even distribution of the displacement during tests. The method of connecting laminates by means of glue joints leads to the connection with the smallest overall dimensions and weight. In the initial research the samples connected by means of different glues were tested.

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Tabélé, Clémence, Marc Montana, Christophe Curti, Thierry Terme, Pascal Rathelot, Sophie Gensollen, and Patrice Vanelle. "Organic Glues or Fibrin Glues from Pooled Plasma: Efficacy, Safety and Potential as Scaffold Delivery Systems." Journal of Pharmacy & Pharmaceutical Sciences 15, no. 1 (January 20, 2012): 124. http://dx.doi.org/10.18433/j39k5h.

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Since 1976, fibrin glues have been attracting medical interest, spreading from their initial use as a hemostatic agent in cardiovascular surgery to other fields of surgery. Studies have compared the efficacy of fibrin glues vs sutures in surgery. However, few comparisons have been made of the efficacy and safety of the different fibrin glues commercially available. Recently, fibrin glues have been tested as a scaffold delivery system for various substances inside the body (drugs, growth factors, stem cells). The infectious risk (viruses, new germs) of this blood-derived product was also studied in assays on viral inactivation methods. The development of autologous fibrin glues offers a solution to the problem of infectious risk. This review examines the current state of knowledge on the efficacy, safety and future potential of fibrin glues. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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McConnell, John. "Gases and glues." Lancet 341, no. 8860 (June 1993): 1589–90. http://dx.doi.org/10.1016/0140-6736(93)90717-u.

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Popov, Viktor, Olga Dornyak, Andrei Latinin, and Elena Lushnikova. "CREATING DURABLE WOOD GLUE STRUCTURES BASED ON PHYSICOMODIFIED ADHESIVES." Voronezh Scientific-Technical Bulletin 4, no. 4 (January 25, 2021): 70–75. http://dx.doi.org/10.34220/2311-8873-2021-4-4-70-75.

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In the past few decades, gluing technologies have been widely used in woodworking, which significantly expand the range of new products. Bonding of products with adhesives is used in the manufacture of furniture, parquet, load-bearing and enclosing structures, door and window blocks, prefabricated houses and many other products. The main criteria for the quality of glued wood joints is the cohesive and adhesive strength of the glued joint. To date, a number of technologies have been developed to improve the strength of glued wood joints. In order to increase the strength of the adhesive bond of wood, technologists propose methods of variation by such factors as temperature, pressure during curing of the adhesive joint, the purity of the surface treatment of substrates, and the thickness of the adhesive layer. A large amount of work and substantial financial costs are spent on creating new brands of adhesives. However, the requirements for glued timber products are not solved by the proposed gluing technologies and new brands of glues. First of all, this concerns the widely used glue wood structures (CDC), as a rule, operating in difficult conditions with high mechanical loads. To solve the problem of increasing the reliability of glue wood structures, instead of domestic imported, but more expensive adhesives are often used. To a certain extent, the creation of more high-strength adhesive joints has recently also been solved by the use of methods for modifying domestic adhesives exposed to irradiation with magnetic and electric fields, as well as ultrasound.

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Shettigar, Manoj P. "Tissue Adhesives in Ophthalmology." UP Journal of Ophthalmology 11, no. 01 (April 5, 2023): 3–7. http://dx.doi.org/10.56692/upjo.2023110102.

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Tissue glue is increasingly becoming a material of choice as an adjuvant to surgical wound closure in ophthalmology. Various types of glues have been unique in terms of their advantages and limitations and so are used in different indications. However, acceptance of these adhesives by clinicians promises this to be a standard procedure for surgical wound closure.

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Rittschof, Daniel, Tara Essock-Burns, Gary Dickinson, S. Zmina, and N. Alberman. "Natural glues and fouling management by interfering with glue curing." Journal of Agricultural and Marine Sciences [JAMS] 20 (January 1, 2015): 34. http://dx.doi.org/10.24200/jams.vol20iss0pp34-39.

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Multidisciplinary approaches and modern technology provide insights to glue curing that are stimulatingand controversial. Our team applies classic and modern theory and techniques to the study of barnacle glue. Techniques include physical measures, bacteriology, behavior, physiology, biochemistry, microscopy, spectroscopy, tomography, tandem mass spectrometry, molecular biology and proteomics. Theory is grounded in evolution and previous literature. Here, we use data from these techniques to support the hypothesis that barnacle glue curing is similar toblood clotting and propose a model for how glue cures. Similar to blood clotting, barnacle glue curing involves enzymatic activation of precursors and rearrangement of structural molecules to form a crosslinked material. Barnacle larval settlement, bacteriology and biochemical data show glue contains large amounts of small peptides. Their role in glue curing has been overlooked. The peptides comprise 15 to 30% of partially cured glue. Because they have little secondary structure, the peptides can associate with binding domains on the substrate and interface with the larger, well-described structural proteins known in barnacle glue. Enzymes participate in curing of barnacle glue. Siloxanes impact glue-curing enzymes. They potentiate trypsin activity and inhibit transglutaminase activity. Changing enzymeactivity impacts how glue cures. Disrupting the curing process of biological glues is central to effective cleaning strategies for fouling management. Thus silicones that interfere with enzyme activity have potential as additives in easy cleansurfaces. The environmental impacts of organosilicones that are generated by biological processes need to be addressed

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Arum, C., I. O. Olofintuyi, and O. O. Ekundayo. "Glulam beams: Performance of PVA and PUR adhesives on bending strengths of locally selected Nigerian timber species." Nigerian Journal of Technology 40, no. 3 (October 20, 2021): 363–70. http://dx.doi.org/10.4314/njt.v40i3.2.

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The applicability of structural timber to construction is due to its desirable qualities such as lightweight, aesthetics and eco-friendliness. However, continuous use of timber for structural purposes comes with the challenge posed by the anisotropic nature of various timber species. Advanced societies have developed and modified their sawn timber species in form of glue-laminated structural members such as beams, columns, joist etc. Nigeria timber species are yet to be fully explored along glued-laminated beams production. This paper assesses the suitability of three selected Nigerian timber species namely; Gmelina Arborea (ML), Terminalia superba (AF) and Pycnanthus angolensis (AK) for production of glued-laminated (glulam) beams. They are locally known respectively as Melina (ML), Afara (AF) and Akomu (AK). The applicability and glue-ability of the glues and their ultimate effect on the flexural strength were investigated through the use of two different types of glue components namely; polyvinyl acetate (PVA) and polyurethane (PUR) glue. The physical properties of the timber species such as moisture content (MC) and densities were determined using BS EN 408. The beams produced which are 1680mm by 150mm by 120mm in dimension were subjected to two points loading system to determine their flexural strengths and failure loads in accordance with ASTM D-198. The flexural strengths results indicated that Pycnanthus angolensis offered most resistance to bending loads with an average flexural strength value of 16.04N/mm2 when PUR glue was used and 13.04N/mm2 when PVA glue was used. The ANOVA result showed that glue types have significant effect on the flexural strength at confidence level of 95%. It was concluded that Pycnanthus angolensis is most suitable for structural applications. PUR is considered the better glue in terms of strength and glue-ability while PVA glue is considered better in terms of workability and applicability based on almost perfect glue line integrity achieved.

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Teasley, Sarah. "Sticky Solutions." Historical Studies in the Natural Sciences 53, no. 3 (June 1, 2023): 278–307. http://dx.doi.org/10.1525/hsns.2023.53.3.278.

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This article explores the agency of animal materiality, class, and context in shaping social values within wood research and manufacturing communities in mid-twentieth-century Japan, with a focus on animal glues (nikawa 膠) in relation to other adhesives. It relates the materiality and affordances of adhesives to their value within multiple technosocial contexts, in which glues made from mammalian skin, bones, and hooves remained the predominant adhesive within wood product manufacturing microenterprises but were being replaced by casein-, soybean-, and carbon-based adhesives in academic and corporate laboratories. Working primarily from research reports and consultation records compiled by industrial research institutes embedded within small-scale manufacturing communities, the article proposes that the materiality of animal glues and the larger assemblage of materials-energy-environment-tools-skill-knowledge present in, between, and around labs and workshops both rendered that materiality highly evident to human users and prompted them to value nikawa in highly divergent ways, depending on class and context. The affordances of animal-based glues, alongside those of plant- and carbon-based glues and other substances used with them in manufacturing, led different social groups to value them differently. The result was a bifurcation of value between adjacent but separate social groups, with workshop owners preferring to use animal glues, even as technical advisors labored to dissolve small workshop owners’ attachment or adherence to animal glues, and to prompt them to adopt newer, more “modern” adhesives as part of industrial rationalization and modernization. This paper is part of a special issue entitled “Making Animal Materials in Time,” edited by Laurence Douny and Lisa Onaga.

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Atar, İlkay, and Fatih Mengeloğlu. "The Effect of Type of Reinforcement, Type of Glue and Reinforcement Place on Mechanical and Physical Properties of LVL." Drvna industrija 75, no. 2 (June 15, 2024): 237–48. http://dx.doi.org/10.5552/drvind.2024.0144.

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This study investigated the effect of the reinforcement type, glue type, and reinforcement placement on the mechanical and physical properties of LVL. In the study, the glues used were phenol- formaldehyde (FF), epoxy (EX), and polyurethane (PU), while reinforcement materials used were glass fiber, basalt, jute, and cotton fabric. The following three reinforcement combinations were applied: the first was on the bottom surface, the second was on the first adhesive line at the bottom, and the third was on both the bottom and the first adhesive line at the bottom. As part of the study, researchers manufactured 9-layer laminated veneer lumber (LVL) using alder veneers for the surface, and poplar veneers for the middle layers. They produced a total of 39 different combinations of LVL. The mechanical and physical properties of the produced samples were determined. According to the test results, bending strength (BS), modulus of elasticity (MOE), oven-dry specific gravity, and equilibrium moisture content of samples were higher with FF than with other glues. While the samples with EX glue provided the lowest values in water absorption and thickness swelling tests, glass fiber-reinforced samples provided the highest mechanical values. In addition, the samples having reinforcement on the bottom surface provided higher BS and MOE values.

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Panov, Nikolai Gennadievich, Sergey Borisovich Vasilyev, and Gennady Nikolaevich Kolesnikov. "Influence of Shungite Modificator on Technological Properties of Polymeric Glue Based on Urea-Formaldehyde Resin." Materials Science Forum 992 (May 2020): 434–38. http://dx.doi.org/10.4028/www.scientific.net/msf.992.434.

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Previously it has been experimentally established that modification of polymeric glue on the basis of urea-formaldehyde resin by adding shungite powder leads to improvement of physical-mechanical properties of wood-particle boards. The goal of the investigation was to establish the influence of the shungite powder, consisting of particles in the size from 50 to 100 nanometers, on such technological properties of glue, as duration of gelatinization and viscosity. It was established: the shortest duration of gelatinization for glues was achieved with shungite addition of 10%; the lowest viscosity depends on the composition of the glue and was achieved with shungite addition from 5 to 10%.

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MILLAR, JOCELYN G. "POISONS, SPRAYS, AND GLUES." BioScience 56, no. 9 (2006): 774. http://dx.doi.org/10.1641/0006-3568(2006)56[774:psag]2.0.co;2.

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Geiger, Thomas M., Sabine C. Schäfer, Johannes K. Dreizler, Michael Walz, and Felix Hausch. "Clues to molecular glues." Current Research in Chemical Biology 2 (2022): 100018. http://dx.doi.org/10.1016/j.crchbi.2021.100018.

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GRIFFIN, Martin, Rita CASADIO, and Carlo M. BERGAMINI. "Transglutaminases: Nature’s biological glues." Biochemical Journal 368, no. 2 (December 1, 2002): 377–96. http://dx.doi.org/10.1042/bj20021234.

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Transglutaminases (Tgases) are a widely distributed group of enzymes that catalyse the post-translational modification of proteins by the formation of isopeptide bonds. This occurs either through protein cross-linking via ∊-(γ-glutamyl)lysine bonds or through incorporation of primary amines at selected peptide-bound glutamine residues. The cross-linked products, often of high molecular mass, are highly resistant to mechanical challenge and proteolytic degradation, and their accumulation is found in a number of tissues and processes where such properties are important, including skin, hair, blood clotting and wound healing. However, deregulation of enzyme activity generally associated with major disruptions in cellular homoeostatic mechanisms has resulted in these enzymes contributing to a number of human diseases, including chronic neurodegeneration, neoplastic diseases, autoimmune diseases, diseases involving progressive tissue fibrosis and diseases related to the epidermis of the skin. In the present review we detail the structural and regulatory features important in mammalian Tgases, with particular focus on the ubiquitous type 2 tissue enzyme. Physiological roles and substrates are discussed with a view to increasing and understanding the pathogenesis of the diseases associated with transglutaminases. Moreover the ability of these enzymes to modify proteins and act as biological glues has not gone unnoticed by the commercial sector. As a consequence, we have included some of the present and future biotechnological applications of this increasingly important group of enzymes.

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MacGillivray, Thomas E. "Fibrin Sealants and Glues." Journal of Cardiac Surgery 18, no. 6 (November 2003): 480–85. http://dx.doi.org/10.1046/j.0886-0440.2003.02073.x.

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36

den Besten, Willem, and J. Russell Lipford. "Prospecting for molecular glues." Nature Chemical Biology 16, no. 11 (August 3, 2020): 1157–58. http://dx.doi.org/10.1038/s41589-020-0620-z.

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Mogaki, Rina, Kou Okuro, and Takuzo Aida. "Molecular glues for manipulating enzymes: trypsin inhibition by benzamidine-conjugated molecular glues." Chemical Science 6, no. 5 (2015): 2802–5. http://dx.doi.org/10.1039/c5sc00524h.

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Basu, Samir, Corrado P. Marini, F. Gregory Bauman, Djamshid Shirazian, Peter Damiani, Robert Robertazzi, Israel J. Jacobowitz, Anthony Acinapura, and Joseph N. Cunningham. "Comparative study of biological glues: cryoprecipitate glue, two-component fibrin sealant, and “French” glue." Annals of Thoracic Surgery 60, no. 5 (November 1995): 1255–62. http://dx.doi.org/10.1016/0003-4975(95)00599-g.

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Swathi Krishna, K. V., L. S. Uma Maheswari, and G. Rajeswari. "Surgical glue- a promising technology for wound healing." International Journal of Research in Pharmaceutical Sciences and Technology 1, no. 1 (May 23, 2018): 9–11. http://dx.doi.org/10.33974/ijrpst.v1i1.18.

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Wound closure is one of the important steps of surgical dressing and suturing is the most commonly used method of wound closure. The process of suturing takes very long time for surgery and increases the patient’s risk of anesthesia awareness. Skin glues are a safe and effective method to close selected wounds. They are also cost-effective and help prevent infection. Ideally, wounds should be less than 4 cm, not contaminated or infected and have skin edges that are not under tension. Wounds should be closed within 12 hours. Novel methods of wound closure have been introduced to address these issues, most notably cyanoacrylate tissue glues. The evidence would suggest that the use of cyanoacrylate tissue glue is associated with a reduction in closure time and costs. On a daily basis, dermasurgeons are facing different kinds of wounds that have to be closed. With a plethora of skin closure materials currently available, choosing a solution that combines excellent and rapid cosmetic results with practicality and cost-effectiveness is preferred.

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Kowaluk, Grzegorz, and Anita Wronka. "Bonding of sawmill birch wood with selected biopolymer-based glues." Annals of WULS, Forestry and Wood Technology 109 (March 31, 2020): 32–36. http://dx.doi.org/10.5604/01.3001.0014.3092.

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Bonding of sawmill birch wood with selected biopolymer-based glues. The aim of the research was to determine the shear strength and in-wood damage share of birch lamellas with the surface shaped by rotary saw cutting and bonded with the use of selected biopolymers, such as gelatine, caseine, gluten and polyvinyl acetate (PVAc), as a reference bonding material. The results show that the highest shear strength was achieved in case of PVAc glue used as a binder. From the tested group of biopolymers, a gelatine/acetic acid mixture gave the highest strength.

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Li, Yan, Yi Jia, Xiao-Lin Wang, Hai Shang, and Yu Tian. "Protein-Targeted Degradation Agents Based on Natural Products." Pharmaceuticals 16, no. 1 (December 28, 2022): 46. http://dx.doi.org/10.3390/ph16010046.

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Natural products are an important source of drug lead compounds, and natural products with significant biological activity are constantly being discovered and used in clinical practice. At present, natural products play an important role in the targeted therapy of cancer, cardiovascular and cerebrovascular diseases, nervous system diseases, and autoimmune diseases. Meanwhile, in recent years, the rise of protein-targeted degradation technologies, such as proteolysis-targeting chimeras (PROTACs) and molecular glues, has provided a new solution for drug resistance caused by clinical molecular-targeting drugs. It is noteworthy that natural products and their derivatives, as important components of PROTACs and molecular glues, play an important role in the development of protein-targeting drugs. Hence, this review summarized the protein-targeted degradation agents based on natural products, such as PROTACs and molecular glues. More natural products with the potential to be used in the development of PROTACs and molecular glues as targeted protein degradation agents are still being investigated.

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Szewczak, Andrzej. "Impact of epoxy resin modification on their strength parameters." Budownictwo i Architektura 18, no. 4 (March 20, 2020): 041–50. http://dx.doi.org/10.35784/bud-arch.727.

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Modifications of polymer composites are one of the fastest developing fields of technology. Research is focused on two directions: obtaining new composites or modifying existing materials. The first group of tests uses methods for preparing new chemical formulas of polymers containing, as the main structural element: carbon (organic polymers) or silicon (inorganic polymers). In the second group, the research consists in seeking methods to modify the properties of polymers. In building construction, among the others types, the glues (adhesive polymers) are used. They are exerted to connect materials with different physical andmechanical properties. Under the influence of the factor initiating the crosslinking reaction (hardener or temperature), the polymers obtain a solid form. The strength of the glued joint depends on the initial parameters of the glue resin and the target substrate of its application.The glued surface is usually the weakest element in this connection in terms of the possibility of damage due to the effects of loads, therefore methods to improve the strength parameters of adhesives are sought. The study presents the results of own research on methods of modification of a selected epoxy resin used in the technique as a glue. In order to ensure effective mixing of the adhesive with the fillers, ultrasound energy was used. After the resin had hardened, tests were carried out to determine the hardness and tensile strength of the obtained composites. Based on the results, SEM analysis and observation of the effect of ultrasound, the phenomena affecting the changes in the above mechanical properties were explained.

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Tousi, Ehsan Taghizadeh, Rokiah Hashim, Sabar Bauk, Mohamad Suhaimi Jaafar, Amer Mahmoud Al-Jarrah, Hamid Kardani, Ali Mohammad Hamdan Abu Arra, and Khalid Saleh Ali Aldroobi. "A Study of the Properties of Animal-Based Wood Glue." Advanced Materials Research 935 (May 2014): 133–37. http://dx.doi.org/10.4028/www.scientific.net/amr.935.133.

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In this study, the green animal-based, which has been prepared by prolonged boiling of the inedible connective tissues of domesticated ungulates, was investigated for adhesive properties. The viscosity of green animal-based wood adhesive was measured and compared with that of urea-formaldehyde (UF) and phenol-formaldehyde (PF) which are widely used synthetic glues in the wood industry. Also, the crude protein, crude fat, crude fiber, nitrogen free extract (NFE) that represents carbohydrate, and ash as the organic components of green animal-based glue was measured. According to the results, the green animal-based wood glue was found suitable to be used in wood industry.

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Rana, Sandeep, Jayapal Reddy Mallareddy, Sarbjit Singh, Lidia Boghean, and Amarnath Natarajan. "Inhibitors, PROTACs and Molecular Glues as Diverse Therapeutic Modalities to Target Cyclin-Dependent Kinase." Cancers 13, no. 21 (November 2, 2021): 5506. http://dx.doi.org/10.3390/cancers13215506.

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The cyclin-dependent kinase (CDK) family of proteins play prominent roles in transcription, mRNA processing, and cell cycle regulation, making them attractive cancer targets. Palbociclib was the first FDA-approved CDK inhibitor that non-selectively targets the ATP binding sites of CDK4 and CDK6. In this review, we will briefly inventory CDK inhibitors that are either part of over 30 active clinical trials or recruiting patients. The lack of selectivity among CDKs and dose-limiting toxicities are major challenges associated with the development of CDK inhibitors. Proteolysis Targeting Chimeras (PROTACs) and Molecular Glues have emerged as alternative therapeutic modalities to target proteins. PROTACs and Molecular glues utilize the cellular protein degradation machinery to destroy the target protein. PROTACs are heterobifunctional molecules that form a ternary complex with the target protein and E3-ligase by making two distinct small molecule–protein interactions. On the other hand, Molecular glues function by converting the target protein into a “neo-substrate” for an E3 ligase. Unlike small molecule inhibitors, preclinical studies with CDK targeted PROTACs have exhibited improved CDK selectivity. Moreover, the efficacy of PROTACs and molecular glues are not tied to the dose of these molecular entities but to the formation of the ternary complex. Here, we provide an overview of PROTACs and molecular glues that modulate CDK function as emerging therapeutic modalities.

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Guhan, Samantha, Si-Liang Peng, Hrag Janbatian, Stephanie Saadeh, Stephen Greenstein, Faisal Al Bahrani, Ali Fadlallah, Tsai-Chu Yeh, and Samir A. Melki. "Surgical adhesives in ophthalmology: history and current trends." British Journal of Ophthalmology 102, no. 10 (March 26, 2018): 1328–35. http://dx.doi.org/10.1136/bjophthalmol-2017-311643.

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Tissue adhesives are gaining popularity in ophthalmology, as they could potentially reduce the complications associated with current surgical methods. An ideal tissue adhesive should have superior tensile strength, be non-toxic and anti-inflammatory, improve efficiency and be cost-effective. Both synthetic and biological glues are available. The primary synthetic glues include cyanoacrylate and the recently introduced polyethylene glycol (PEG) derivatives, while most biological glues are composed of fibrin. Cyanoacrylate has a high tensile strength, but rapidly polymerises upon contact with any fluid and has been associated with histotoxicity. Fibrin induces less toxic and inflammatory reactions, and its polymerisation time can be controlled. Tensile strength studies have shown that fibrin is not as strong as cyanoacrylate. While more research is needed, PEG variants currently appear to have the most promise. These glues are non-toxic, strong and time-effective. Through MEDLINE and internet searches, this paper presents a systematic review of the current applications of surgical adhesives to corneal, glaucoma, retinal, cataract and strabismus surgeries. Our review suggests that surgical adhesives have promise to reduce problems in current ophthalmic surgical procedures.

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Liu, Yuan, Mads Larsen, Bo Lin, Irene A. Cardenal, Jason R. Kennerdell, Toren Finkel, and Bill B. Chen. "Abstract 6070: Identification of a molecular glue degrader that engages a cancer-specific E3 ligase." Cancer Research 84, no. 6_Supplement (March 22, 2024): 6070. http://dx.doi.org/10.1158/1538-7445.am2024-6070.

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Abstract To date, most successful molecular glues have leveraged ubiquitously expressed E3 ligases, most notably Cereblon in the case of the thalidomide derivatives. However, a number of specific E3 ligases are highly over-expressed in certain tumors. Compounds that engage such tumor-specific E3 ligases might provide a unique opportunity to develop molecular glues with higher therapeutic indexes. One such tumor-specific E3 ligase is FBXO5, a member of the F-box family of E3 ligases. Expression analysis suggests this E3 ligase is highly expressed in a wide array of tumor tissues when compared to the corresponding normal tissue, and that within a given tumor type, higher FBXO5 expression correlates with advanced tumor stage and worse disease-free survival. Here, we describe a small molecule (MW~400 Daltons) that uses FBXO5 to function as a molecular glue degrader. This compound, CL-200, exerts cytotoxicity in the nanomolar range across a number of diverse tumor types. The cytotoxicity of CL-200 is abrogated when FBXO5 is knockdown using siRNA. We have further determined that CL-200 induces the FBXO5-dependent proteasomal degradation of at least two critical neosubstrates. One identified neosubstrate is the p150 isoform of ADAR1, an enzyme that catalyzes the posttranscriptional conversion of adenosine to inosine in double-stranded RNA (dsRNA). Evidence suggests that ADAR1p150 is the isoform that confers oncogenic and immune modulating effects in many tumors. Another neosubstrate targeted by CL-200 is c-myc, a critical transcription factor linked to a wide array of tumors. Of note, both p150 ADAR1 or c-myc have been viewed as difficult-to-drug if not undruggable targets. As such, these data suggests that CL-200 functions as a novel molecular glue degrader that engages the cancer-specific E3 ligase FBXO5 to degrade both p150 ADAR1 and c-myc. Structural alteration of CL-200 suggest that chemical modifications can be made that retain the engagement with FBXO5 while altering the neosubstrate profile. Together, these results demonstrate the possibility of leveraging cancer-specific E3 ligases to develop novel molecular glues. Citation Format: Yuan Liu, Mads Larsen, Bo Lin, Irene A. Cardenal, Jason R. Kennerdell, Toren Finkel, Bill B. Chen. Identification of a molecular glue degrader that engages a cancer-specific E3 ligase [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 6070.

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Dasiewicz, Julia, and Anita Wronka. "Influence of the use of chestnut starch as a binder filler in plywood technology." Annals of WULS, Forestry and Wood Technology 122 (June 30, 2023): 137–48. http://dx.doi.org/10.5604/01.3001.0053.9126.

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: Influence of the use of chestnut starch as a binder filler in plywood technology. Fillers play a crucial role in the production of plywood glues, providing enhanced performance and stability to the end product. Plywood, being a composite material, requires fillers to improve its mechanical properties, adhesion, and overall quality. One common filler used in plywood glues is calcium carbonate. It acts as a bulking agent, increasing the volume and density of the adhesive mixture while reducing production costs. Calcium carbonate also enhances the glue's viscosity, ensuring proper bonding and uniform application during the plywood manufacturing process. Another widely used filler is rye or wheat flour, which consists of finely ground grains. The flour not only improves the adhesive's viscosity but also contributes to the overall strength and stability of the plywood. It helps to prevent warping and enhances dimensional stability, making the final product more durable. Additionally, other fillers like talc or clay minerals may be incorporated into the glues to improve their adhesive properties and increase moisture resistance. Chestnut starch is a type of vegetable flour made by grinding edible chestnuts into a powder. It has a different texture and properties than traditional wheat or rye flour. When used as a binder filler in plywood technology, it can be biodegradable and environment-friendly. In the study, there were produced five types of plywood with 0, 1, 5, 10, and 20 parts by weight chestnut flour and one reference. All samples were produced in laboratory conditions and the selected mechanical and physical properties of the produced boards were studied. The mechanical properties of the boards increased with the addition of chestnut flour. In some tests, the results even met the highest requirements of European standards for plywood. According to this finding, a well-chosen addition of chestnut flour could be positively considered in plywood production.

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Macdougall, I. C., C. Isles, J. S. Oliver, J. C. Clark, and W. G. S. Spilg. "Fatal Outcome following Inhalation of Tipp-Ex." Scottish Medical Journal 32, no. 2 (April 1987): 55. http://dx.doi.org/10.1177/003693308703200213.

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Recent measures to combat glue sniffing1,2 have led to a decrease in the availability of toluene-based glues. As a result, abuse of other more accessible solvents appears to have increased. Of particular concern are the halogenated hydrocarbons which are more likely to cause fatal cardiac arrhythmias than toluene3. We wish to report three cases presenting within a period of six months where death occurred following inhalation of Tipp-Ex, a seemingly innocuous preparation of 1,1,1-trichloroethane which is widely available in offices and schools.

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Della Sala, Francesca, Birgitte Mølholm Malle, Luigi Ambrosio, and Assunta Borzacchiello. "Fermentation-Derived Albumin-Based Hydrogels for Tissue Adhesion Applications." Polymers 15, no. 11 (May 31, 2023): 2530. http://dx.doi.org/10.3390/polym15112530.

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Currently, most of the clinically available surgical glues and sealants lack elasticity, good adhesion and biocompatibility properties. Hydrogels as tissue adhesives have received extensive attention for their tissue-mimicking features. Here, a novel surgical glue hydrogel based on a fermentation-derived human albumin (rAlb) and biocompatible crosslinker for tissue-sealant applications has been developed. In order to reduce the risks of viral transmission diseases and an immune response, Animal-Free Recombinant Human Albumin from the saccharomyces yeast strain was used. A more biocompatible crosslinking agent, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), was used and compared with glutaraldehyde (GA). The design of crosslinked albumin-based adhesive gels was optimized by varying the albumin concentration, the mass ratio between albumin and the crosslinking agent as well as the crosslinker type. Tissue sealants were characterized in terms of mechanical (tensile and shear), adhesive and in vitro biocompatibility properties. The results indicated that the mechanical and adhesive properties improved as the albumin concentration increased and the mass ratio between albumin and crosslinker decreased. Moreover, the EDC-crosslinked albumin gels have better biocompatibility properties than GA-crosslinked glues.

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Schreiber, Stuart L. "The Rise of Molecular Glues." Cell 184, no. 1 (January 2021): 3–9. http://dx.doi.org/10.1016/j.cell.2020.12.020.

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Journal articles on the topic 'Glues'

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