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Dissertations / Theses on the topic 'Glutamate and aspartate'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Fisch, Florian A. "Catalytic plasticity of the aspartate/glutamate racemase superfamily." Thesis, University of York, 2009. http://etheses.whiterose.ac.uk/799/.

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The bacterial and archaeal Asp/Glu racemase enzyme superfamily contains a variety of catalytic functions that have great potential for use in industrial biocatalysis. Members of this superfamily include aspartate racemases (AspRs), glutamate racemases (GluRs), hydantoin racemases (HydRs), arylmalonate decarboxylases (AMDs) and maleate cis-trans isomerases (MIs). Despite their catalytic diversity, all characterised members share the same protein fold, catalytic cysteine residues and reaction intermediate. Attempts to exploit this evolutionary flexibility for new processes have had limited succe

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2

Crawford, Martin. "Neurotransmitter interactions within the rat neostratum." Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280360.

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3

Yassin, Maged M. I. "N-methyl-D-aspartate, anoxia and glutamate antagonists in mammalian brain." Thesis, Queen's University Belfast, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241524.

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4

Thangaratnarajah, Chancievan. "The structural and functional characterisation of the mitochondrial aspartate-glutamate carriers." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708769.

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5

Tofighy, Azita. "N-methyl-d-aspartate receptor desensitisation and anoxia in rat olfactory cortex." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361309.

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6

Dean, Jonathan Lewis. "The roles of aspartate and arginine in the active site of glutamate dehydrogenase." Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388695.

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7

Williams, Helen. "The transport and cardioprotective action of glutamate and aspartate in isolated ventricular myocytes." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299276.

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8

Hulme, Julie Anne. "Ultrastructural and immunocytochemical studies of the glutamate/aspartate transporter, GLAST, and its relationship to glutamate handling in the mammalian cochlea." Thesis, Keele University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401057.

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9

Hobbs, Catherine M. "The functional expression of N-methyl-D-aspartate glutamate-type receptors by megakaryocytes and platelets." Thesis, University of Bath, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527791.

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This study investigated the role of NMDARs in the differentiation of MEG-01 cells and in the activation of human platelets. This investigation demonstrated that the NR1, NR2D and NR3 subunit proteins are expressed in human platelets, with the NR1 subunit also expressed in MEG-01 cells. The NR2A subunit protein was not detectable in either MEG-01 cells or human platelets. PMA-induced differentiation of MEG-01 cells did not appear to stimulate changes in expression of any of the subunit proteins tested. Using assays to measure the changes in [Ca2+]i and ATP secretion, it was determined that dono

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10

Bright, Nieka L. "Glutamate Receptor, Ionotropic N-methyl-D-aspartate 2B Polymorphisms and Concussive Recovery in Athletes." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/216565.

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Kinesiology<br>Ph.D.<br>Athletes vary in their ability to recover from concussions. Following a concussion, a pathophysiological cascade of events transpires, rendering symptoms. One such event, the indiscriminate release of the excitatory neurotransmitter glutamate, may result in hyperactivation of glutamate receptors (e.g., N-methyl-D-aspartate receptors [NMDARs]) and self-propagate a state of neurotoxicity that may be enhanced via the concomitant release of Ca2+, particularly through NMDARs containing the NR2B subunit. Genetic variation in regulatory regions of the glutamate receptor, ionot

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11

Mozley, L. S. "A neurochemical investigation into the role of aspartate and glutamate as neurotransmitters in thalamic efferents of the rat." Thesis, University of Bristol, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234826.

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12

Thompson, Gareth Andrew. "Neurochemical and electrophysiological studies of sulphur-containing analogues of glutamate and aspartate in the rat central nervous system." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261366.

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13

Etchepare, Laetitia. "Role of glutamate N-Methyl-D-Aspartate receptor surface trafficking in the firing pattern of midbrain dopaminergic neurons." Thesis, Bordeaux, 2017. http://www.theses.fr/2017BORD0849/document.

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Les neurones dopaminergiques (DA) mésencéphaliques jouent un rôle prépondérant dans de nombreuses fonctions cérébrales telles que la motivation, mais ils sont également impliques dans l’émergence de pathologies telles que la maladie de Parkinson et l’addiction aux drogues. Ces processus ayant en commun de modifier l’activité de décharge des neurones DA mésencéphaliques, il est d’une importance primordiale de comprendre les mécanismes sous-tendant cette activité. Parmi les différents canaux ioniques et récepteurs impliques dans la génération de l’activité de décharge des neurones DA, les récept

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14

Nguyen, Khoa Thuy Diem. "Energy metabolism in the brain and rapid distribution of glutamate transporter GLAST in astrocytes." University of Sydney, 2008. http://hdl.handle.net/2123/3996.

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Doctor of Philosophy (Medicine)<br>Glutamate transporters play a role in removing extracellular excitatory neurotransmitter, L-glutamate into the cells. The rate of the uptake depends on the density of the transporters at the membrane. Some studies claimed that glutamate transporters could transit between the cytoplasm and the membrane on a time-scale of minutes. The present study examined the distribution of glutamate transporter GLAST predominantly expressed in rat cortical cultured astrocytes between the membrane and the cytoplasm by using deconvolution microscopy and then analyzing the

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15

Martel, Marc-Andre´. "Role of the NR2 subunit composition and intracellular C-terminal domain in N-methy-D-aspartate receptor signalling." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4228.

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N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ionotropic receptors. When activated, NMDARs let extracellular sodium and calcium ions enter neurons. This calcium influx, depending on its duration, intensity and the presence of nearby signalling proteins can signal to synaptic plasticity. Additionally, physiological NMDAR activity promotes pro-survival cascades and gene transcription, whereas both lack of activation and overactivation of these receptors trigger pro-death signals. Several neurodegenerative pathologies such as stroke/ischemia and Alzheimer’s disease are thought to in

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16

Boukroute, Azzouz. "Étude physicochimique et immunologique des glutamate oxaloacétate transaminases de l'ascomycète sphaérostilbe repens." Nancy 1, 1988. http://www.theses.fr/1988NAN10023.

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La glutamate oxaloacétate transaminase (GOT) catalyse la réaction suivante : aspartate + a-cétoglutarate. Chez Sphaerostilbe repens, la GOT est constituée de deux isoformes. La première (GOT1) est localisée dans la matrice mitochondriale, la deuxième isoforme (GOT2) est cytosolique. Les deux isoformes de la GOT ont été purifiées à homogénéité et leurs propriétés physicochimiques ont été étudiées. L'étude immunologique de deux isoformes montre que les anticorps dirigés contre la GOT mitichondriale ne reconnaissent pas la GOT cytosolique. La richesse des thalles en GOT1 a été analysée par test E

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17

Richards, Dannette Shanon. "CHARACTERIZATION OF EXCITATORY AMINO ACID NEUROTRANSMITTERS AT MOTONEURON SYNAPSES CONTACTING RENSHAW CELLS." Wright State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1260896604.

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18

Axerio-Cilies, Peter. "Discovery of a selective GluN2A-containing N-methyl-d-aspartate glutamate receptor positive modulator as a novel post-stroke neuroprotective therapy." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/59498.

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N-methyl-d-aspartate glutamate receptors (NMDARs) are fundamental to many normal brain functions such as cognition and memory; however, NMDAR over-activation can cause neuronal death as a result of excitotoxicity. Although the mechanisms underlying these paradoxical roles of NMDARs remain unclear, accumulating evidence from both in-vitro and in-vivo studies suggested that GluN1/GluN2B-NMDAR subtypes mediated signaling may contribute cell death, while GluN1/GluN2A-NMDARs signaling promote pro-survival outcomes. Employing an extensive drug discovery pipeline process, we identified and characteri

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19

Yongtao, Zhang, and Zhang Yongtao. "Synthesis and structural characterization of silver (I)-(D-, L- and DL-) aspartate and silver (I)-(D- and L-) glutamate coordination polymers." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/626799.

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Chiral assemblies of metal atoms linked by organic ligands are attracting considerable attention for their unique structural aesthetics and interesting properties. In order to explore the novel helical supramolecular of silver with amino acid complexes and develop the potential applications of them, the silver nitrate and two types of amino acid (L-, D- and DL-) aspartic acid and (L- and D-) glutamic acid are used to generate chiral silver(I) coordination polymers. In this work, five coordination polymers, {[Ag3(D-Asp)2(NO3)]}n. nH2O (1), {[Ag3(L-Asp)2(NO3)]}n. nH2O (2), {[Ag4(DL-Asp)2(NO3)2]}

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20

CARTOUX, LAURENCE. "Application des methodes biochimiques a la chimie organique : utilisation de proteases pour la synthese de peptides contenant les residus aspartate et glutamate." Clermont-Ferrand 2, 1989. http://www.theses.fr/1989CLF21194.

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Dans la premiere partie les principes de base de la catalyse enzymatique en synthese peptidique sont exposes. Ensuite, les resultats de la litterature concernant les serines proteases, les thiol proteases et les metalloproteases sont resumes. La deuxieme partie presente les resultats obtenus. Parmi les metalloproteases la thermolysine a surtout ete etudiee. Les resultats montrent que seule la phenylalanine peut etre couplee a l'acide aspartique. La phenylalanine joue alors un role d'activateur de la thermolysine. Le greffage d'un residu phenylalanine sur la thermolysine conduit a une enzyme mo

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21

Okada, Mikiko. "Blockade of the N-methyl-D-aspartate-type glutamate receptor in the animal : Target for neuroprotection in head trauma and brain ischemia." Kyoto University, 1998. http://hdl.handle.net/2433/182421.

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22

Vunck, Sarah A. "A COMPARISON OF THE DISCRIMINATIVE STIMULUS PROPERTIES OF THE ATYPICAL ANTIPSYCHOTIC CLOZAPINE AND THE GLUTAMATE AGONIST N-METHYL D-ASPARTATE IN C57BL/6 MICE." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1691.

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The glutamate system dysfunctions present in schizophrenia raise new questions about possible glutamatergic actions of the atypical antipsychotic clozapine. While clozapine has been shown to partially substitute for the discriminative stimulus of the glutamate agonist N-methyl D-aspartate (NMDA) in rats, NMDA discrimination has not previously been established in mice. The present study was designed to explore the possible role of NMDA activity in clozapine’s discriminative stimulus. Two groups of C57BL/6 mice were trained to discriminate either 2.5 mg/kg CLZ from vehicle or 30 mg/kg NMDA from

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23

Ghomeshi, Hooman Reza. "The effects of exogenous L-aspartate and L-glutamate during ischemia-reperfusion for cardiac surgery, a magnetic resonance study in isolated pig hearts." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0013/MQ32920.pdf.

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24

Passerat, Nelly. "Catalyse enzymatique en synthese organique : utilisation de la glutamate oxaloacetate aminotransferase pour la production d'analogues des acides aspartique et glutamique." Clermont-Ferrand 2, 1987. http://www.theses.fr/1987CLF2S879.

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Nous nous sommes proposes de synthetiser par voie enzymatique 2 acides amines particuliers: l'acide hydroxyaspartique et l'acide hydroxyglutamique. Les syntheses sont catalysees par la glutamate oxaloacetate transaminase (got) du coeur de porc (enzyme purifiee accessible dans le commerce). Nous avons utilise la got immobilisee de facon covalente sur un support insoluble selon la methode de a. Pollack, g. Whitesides (43). L'enzyme immobilisee presente environ 40% de son activite initiale et possede une bonne stabilite. Apres chaque synthese le gel contenant l'enzyme isole peut etre reutilise de

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25

Anaparti, Vidyanand. "Role of N-methyl-D-aspartate receptors in the regulation of human airway smooth muscle function and airway responsiveness." American Physiological Society, 2015. http://hdl.handle.net/1993/30657.

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Increased airway smooth muscle (ASM) mass contributes to airway hyperresponsiveness (AHR) in asthma and is orchestrated by growth factors, cytokines and chemokines. Airway contractile responses are influenced by neuromediators, such as acetylcholine, and glutamate released by parasympathetic and sympathetic airway nerves. Hyperactivity of these neural elements, termed neurogenic inflammation, is linked with hypercontractility and AHR. Glutamate is a non-essential amino acid derivative, and its physiological role is traditionally considered with respect to its being the primary excitatory neuro

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26

Nilsson, Linda K. "Glutamatergic mechanisms in schizophrenia: role of endogenous kynurenic acid /." Stockholm : Dept. of Physiology and Pharmacology, Karolinska institutet, 2005. http://diss.kib.ki.se/2005/91-7140-538-0/.

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27

Sims-Robinson, Catrina Suppiramaniam Vishnu. "Differential modulation of glutamatergic synaptic transmission by polysialic acid." Auburn, Ala, 2007. http://hdl.handle.net/10415/1352.

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28

Bharadwaj, Rahul. "Regulation of Higher Order Chromatin at GRIN2B and GAD1 Genetic Loci in Human and Mouse Brain: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/651.

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Little is known about higher order chromatin structures in the human brain and their function in transcription regulation. We employed chromosome conformation capture (3C) to analyze chromatin architecture within 700 Kb surrounding the transcription start site (TSS) of the NMDA receptor and schizophrenia susceptibility gene, GRIN2B, in human and mouse cerebral cortex. Remarkably, both species showed a higher interaction between the TSS and an intronic sequence, enriched for (KRAB) Krueppel associated Box domain binding sites and selectively targeted by the (H3K9) histone 3 lysine 9 specific me

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Bharadwaj, Rahul. "Regulation of Higher Order Chromatin at GRIN2B and GAD1 Genetic Loci in Human and Mouse Brain: A Dissertation." eScholarship@UMMS, 2002. http://escholarship.umassmed.edu/gsbs_diss/651.

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Little is known about higher order chromatin structures in the human brain and their function in transcription regulation. We employed chromosome conformation capture (3C) to analyze chromatin architecture within 700 Kb surrounding the transcription start site (TSS) of the NMDA receptor and schizophrenia susceptibility gene, GRIN2B, in human and mouse cerebral cortex. Remarkably, both species showed a higher interaction between the TSS and an intronic sequence, enriched for (KRAB) Krueppel associated Box domain binding sites and selectively targeted by the (H3K9) histone 3 lysine 9 specific me

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30

Rafiki, Bassera Amina. "Les récepteurs au glutamate de type NMDA : étude de leur expression au cours du développement et dans deux modèles animaux d'épilepsie ; étude des relations structure/fonction et des interactions avec les protéines à domaines PDZ." Paris 11, 1999. http://www.theses.fr/1999PA11T029.

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Le Glutamate est le principal neurotransmetteur excitateur dans le SNC. Ses effets sont médiés par sa liaison à une famille de récepteurs membranaires. Parmi ces récepteurs, ceux de type NMDA jouent un rôle important dans le développement neuronal et dans les processus d'apprentissage et de mémorisation du fait de leur perméabilité au Ca2+. Ces récepteurs sont également impliqués dans diverses neuropathologies notamment dans les lésions neuronales associées à l'épilepsie. Nous avons étudié la régulation de l'expression des sous unités NR1 et NR2 du récepteur NMDA au cours du développement neur

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31

Boudet, Nathalie. "Analyse de l'évolution du génome d'Arabidopsis thaliana par l'étude de familles de gènes." Paris 7, 2002. http://www.theses.fr/2002PA077033.

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32

Grégoire, Muriel Hautefeuille Michel. "Kétamine, neuropsychopharmacologie, usages et mésusages." Créteil : Université de Paris-Val-de-Marne, 2005. http://doxa.scd.univ-paris12.fr:80/theses/th0233900.pdf.

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33

Kalinine, Eduardo. "Efeitos do decanoato de nandrolona na homeostasia glutamatérgica e no comportamento agressivo." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/112063.

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Nos últimos anos, houve um aumento significativo no uso abusivo dos Esteróides Anabólicos Andrógenos (EAAs). Um dos efeitos comportamentais mais marcantes da administração crônica de EAAs como o Decanoato de Nandrolona (DN) é a indução do comportamento agressivo exacerbado. Atualmente o sistema glutamatérgico tem sido associado ao comportamento agressivo induzido pelos EAAs, principalmente no que se refere à modulação dos receptores N-Methyl-D-Aspartato NMDA (NMDAr). Nós investigamos os efeitos centrais e periféricos da administração do DN ao longo do tempo (4, 11 e 19 dias consecutivos de adm

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34

Morgan, Megan Jayne. "Identification of molecular-genetic determinants of quality traits of tomato fruit." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:662d8b1e-70cf-44fb-9ed3-46dcacc39bad.

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Tomato is an important food crop and a model for fleshy fruit development. The process of fruit ripening involves changes in chemical composition and in particular the accumulation of sugars, organic, amino acids and carotenes. The research described in this thesis aimed to identify key regulatory aspects associated with the accumulation of the major acids in tomato fruit by analysis of introgression lines resulting from a cross between a cultivated variety, Solanum lycopersicum, and a wild progenitor species, Solanum pennellii. Line 2-5 showed increases in citrate, malate, aspartate and gluta

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35

Saliba, Layal. "Etude de la transmission glutamatergique et des effets de l'ozone dans le noyau du tractus solitaire de rat adulte." Aix-Marseille 2, 2009. http://www.theses.fr/2009AIX20722.

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Ce travail s'inscrit dans le cadre de l'étude des mécanismes d'intégration de l'information viscérale en réponse à des perturbations environnementales. La première partie de nos résultats suggère que les neurones du noyau du tractus solitaire (NTS) pourraient utiliser un mode de neurotransmission différent en fonction de leur lieu de projection. Dans les neurones impliqués dans la genèse des réflexes vitaux comme la respiration, l'absence majoritaire de courant iA et une transmission synaptique s'appuyant essentiellement sur les récepteurs AMPA avec des récepteurs NMDA peu accessibles, permett

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36

Mony, Laetitia. "Modulateurs allostériques des récepteurs NMDA contenant la sous-unité GluN2B : sites de liaison et mécanismes d'action." Paris 5, 2010. http://www.theses.fr/2010PA05S005.

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Les récepteurs NMDA (rNMDA) forment une classe de récepteurs-canaux membranaires activés par le glutamate, le principal neurotransmetteur excitateur du cerveau des Vertébrés. Ils jouent un rôle prépondérant dans l'initiation de différentes formes de plasticité synaptique mais sont également impliqués dans diverses pathologies comme les ischémies cérébrales, les douleurs chroniques ou la schizophrénie. Les composés régulant l'activité des rNMDA ont donc un fort intérêt thérapeutique. De façon remarquable, les rNMDA possèdent de nombreux sites modulateurs extracellulaires pouvant lier des ions o

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37

Loureiro, Camila Marcelino. "Quantificação sérica das subunidades NR1 e NR2 do receptor N-Metil-D-Aspartato em primeiro episódio de transtorno mental com manifestações psicóticas." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17138/tde-10012017-094940/.

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Introdução: Os receptores ionotrópicos do glutamato, como o N-metil-D-Aspartato (NMDA), estão envolvidos em desordens psiquiátricas. NMDARs são complexos heteroméricos que incorporam tres diferentes subunidades: NR1, NR2 e NR3. Objetivos: quantificar os níveis plasmáticos das subunidades NR1 e NR2 NMDAR em pacientes em primeiro episódio psicótico (PEP), em comparação com os irmãos e controles saudáveis. Métodos: Este é um estudo transversal de PEP na região de Ribeirão Preto, Brasil, sendo o grupo controle composto por indivíduos saudáveis, pareados por idade, sexo e mesma área de abrangência

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Schulz, Christian [Verfasser], and Dirk [Akademischer Betreuer] Gründemann. "SLC22A13 katalysiert den unidirektionalen Efflux von Aspartat und Glutamat / Christian Schulz. Gutachter: Dirk Gründemann." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2015. http://d-nb.info/1069199524/34.

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39

Peineau, Stéphane. "La somatostatine dans la modulation de la transmission synaptique glutamatergique : un inhibiteur dépendant de l'activité ?" Paris 6, 2002. http://www.theses.fr/2002PA066289.

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Oliveira, Alanny Bahia de. "Envolvimento do receptor NMDA de glutamato na ansiedade experimental induzida pela pilocarpina." reponame:Repositório Institucional da UFSC, 2014. https://repositorio.ufsc.br/xmlui/handle/123456789/129339.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2014.<br>Made available in DSpace on 2015-02-05T20:58:29Z (GMT). No. of bitstreams: 1 327702.pdf: 2174850 bytes, checksum: d91a97be57c43c41d3fa9c447b791113 (MD5) Previous issue date: 2014<br>A ansiedade é vista pela ciência moderna como um conjunto de comportamentos, com respostas endócrinas e fisiológicas, que objetivam proteger o indivíduo de possíveis ameaças. Um teste amplamente utilizado na pesquisa da ansiedade é o labirinto em cruz e

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Cattani, Adriano Augusto Giaquinto [UNIFESP]. "Crises paroxísticas recorrentes em ratos por inibição do transporte de glutamato durante o desenvolvimento." Universidade Federal de São Paulo (UNIFESP), 2009. http://repositorio.unifesp.br/handle/11600/9282.

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Made available in DSpace on 2015-07-22T20:49:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-08-26<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Institut National de la Santé et de la Recherche Médicale (INSERM)<br>Fédération pour la Recherche sur le Cerveau (FRC)<br>Ligue Française Contre l'Épilepsie (LFCE)<br>Foi mostrado anteriormente que os transportadores de glutamato controlam eficientemente atividade de rede no cérebro imaturo de roedores prevenindo a geração de crises. Em particular, inibição de transportadores de glutamato pelo DL-TBOA produz u

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42

Rodolphi, Marcelo Salimen. "Efeitos da nandrolona e da ceftriaxona na homeostasia glutamatérgica : uma busca por mecanismos interativos entre astrócitos e neurônios envolvidos no comportamento agressivo." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/157966.

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Os esteroides anabolizantes androgênicos (EAA) como o decanoato de nandrolona (ND) são hormônios sintéticos derivados da testosterona. Sabe-se que um dos efeitos mais marcantes da administração abusiva destes esteroides é o aumento do comportamento agressivo. Evidências indicam que altas doses de EAA alteram a morfologia e causam hiperativação de sinapses glutamatérgicas, o que se correlaciona com um fenótipo agressivo exacerbado. Fisiologicamente o glutamato é considerado o principal neurotransmissor excitatório no cérebro de mamíferos, entretanto, em níveis elevados, pode causar hiperexcitab

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43

Liu, Pingyang. "Biochemical studies of enzymes in insect cuticle hardening." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/50528.

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In insects, the cuticle provides protection against physical injury and water loss, rigidness for muscle attachment and mechanical support, and flexibility in inter-segmental and joint areas for mobility. As most insects undergo metamorphosis, they need to shred off old cuticle and synthesize new cuticle to fit the body shape and size throughout their life cycles. The newly formed cuticle, mainly composed of cuticular proteins, chitin, and sclerotizing reagents, needs to be hardened through the crosslinks between cuticular proteins and sclerotizing reagents. This dissertation concerns the bioc

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Landim, Ricardo Cesar Giorgetti 1986. "Utilização da fMRS para o estudo da variação de N-acetil-aspartato e N-acetil-aspartil-glutamato durante a ativação cerebral." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/277856.

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Orientador: Gabriela Castellano<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Física Gleb Wataghin<br>Made available in DSpace on 2018-08-21T20:54:35Z (GMT). No. of bitstreams: 1 Landim_RicardoCesarGiorgetti_M.pdf: 17116375 bytes, checksum: 1ddc2a2b2cc8da480f9f40a006e4144a (MD5) Previous issue date: 2013<br>Resumo: As variações metabólicas que ocorrem no cérebro subjacentes á ativação neuronal ainda estão longe de ser bem compreendidas e, portanto, constituem objeto de estudo de grande interesse por parte da comunidade cientifica da área. Uma forma de estudar es

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Mekki, Sofiane. "Synthèse de nouveaux dérivés de l'acide β-hydroxyaspartique β-Substitués : inhibiteurs du transport du glutamate dans le Système Nerveux Central (SNC)". Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20079/document.

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Nos travaux ont porté sur la mise au point de synthèse de nouveaux dérivés β-substitués β-hydroxy aspartates : Inhibiteurs du transport du glutamate dans le système nerveux centrale (SNC). Ces analogues d'aspartates ont été caractérisés par différentes méthodes spectroscopiques (RMN-1H, RMN-13C et HRMS) et leur pureté énantiomérique a été confirmée par analyses HPLC chirale et des mesures de pouvoir rotatoire. Ce manuscrit est organisé en trois chapitres : la première partie présente un point bibliographique sur le système glutamatergique dans le SNC, en rappelant les différents récepteurs et

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Villegas, Bruguera Eulalia Balbina. "Estudio autorradiográfico de las alteraciones de los receptores N-metil-D-aspartato (NMDA) del glutamato en el sistema nervioso central en consumidores crónicos de alcohol." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/401871.

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INTRODUCCIÓN Los mecanismos celulares y moleculares a través de los cuales produce sus efectos son, por ahora, mal conocidos. En los últimos años se está valorando con gran interés la interacción existente entre el etanol y el glutamato. Se han realizado múltiples experimentos con animales de laboratorio que han demostrado que el etanol es un potente inhibidor de la acción del glutamato sobre los receptores NDMA, surgiendo la hipótesis de que la relación etanol-NDMA condiciona parte de los efectos lesivos del tóxico sobre el sistema nervioso central (SNC). OBJETIVOS 1.- Estudiar, medi

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Waltermann, Katharina Monika [Verfasser], Matthias [Akademischer Betreuer] Fischer, M. [Akademischer Betreuer] Buerke, and R. A. [Akademischer Betreuer] Herbst. "Vergleich der N-Methyl-D-Aspartat-Rezeptor-Antagonisten MK-801, AP-5 und D-Glutamat bei humanen Keratinozyten / Katharina Monika Waltermann. Betreuer: Matthias Fischer ; M. Buerke ; R. A. Herbst." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2010. http://d-nb.info/1025054903/34.

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Morillo, Cazorla Margarita. "Ésteres alquílicos de los ácidos poli(gama-glutámico) y poli(beta-aspártico): síntesis, estructura y propiedades." Doctoral thesis, Universitat Politècnica de Catalunya, 2002. http://hdl.handle.net/10803/6427.

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Se han obtenido y caracterizado una serie de poli(a-n-alquil g-glutamato)s (PAAG-n) con n³12 y de poli(a-n-alquil b,L-aspartato)s (PAALA-n), mediante transesterificación con n-alcoholes y se ha estudiado la influencia que ejerce el grupo lateral sobre la estructura y propiedades de estos polímeros. <br/><br/>Los polímeros se han caracterizado mediante FTIR, RMN de 1H y 13C y análisis elemental. La composición enantiomérica se ha determinado midiendo rotaciones específicas de los polímeros hidrolizados y/o mediante HPLC. Los pesos moleculares se han evaluado por viscosimetría y/o SEC/LS. La car

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Faure, Michel. "Étude de la structure et de l'expression des gènes de biosynthèse des pyrimidines chez Dictyostelium discoideum." Paris 11, 1987. http://www.theses.fr/1987PA112313.

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Dans cette thèse nous apportons une contribution à l'étude de la structure des gènes de biosynthèse des pyrimidines chez Dictyostelium discoideum et nous analysons leur expression sous différentes conditions. Sur l'un des plasmides portant le gène DdPYB4 obtenus par complémentation de la mutation ura1 de levure nous avons découvert une partie d'un nouveau gène. Afin d'identifier ce gène nous avons cloné la partie manquante et séquencé deux régions représentant 65% de la séquence codante estimée à 7,2 kb. Les activités enzymatiques codées par ce gène ont été identifiées par les analogies de séq

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Milenkovic, Marija. "Developmental Consequences of N-methyl-D-aspartate Receptor Hypofunction." Thesis, 2011. http://hdl.handle.net/1807/31342.

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NMDA receptor signaling is required for proper synapse formation, maintenance, plasticity and function. Dysregulation of the NMDA receptor has been implicated in pathophysiology of schizophrenia, which has an adult onset of symptoms. NMDA receptor deficient mice were utilized to assess the developmental consequences of NMDA receptor hypofunction. Locomotor activity was elevated throughout development; however, deficits in social interaction and working memory only manifest in adulthood and did not progress with age. Age-dependent deficits in neuron synapse biology were also detected; posts

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