Relevant bibliographies by topics / Glutamic acid – Receptors – Effect of drugs on

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Academic literature on the topic 'Glutamic acid – Receptors – Effect of drugs on'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 February 2022

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Journal articles on the topic "Glutamic acid – Receptors – Effect of drugs on"

1

KANIA, BOGDAN FELIKS, URSZULA BRACHA, GRZEGORZ LONC, and TOMASZ WOJNAR. "Significance of metabotropic glutamate receptor antagonists in experimental neuropathic pain in animals." Medycyna Weterynaryjna 76, no. 10 (2020): 6460–2020. http://dx.doi.org/10.21521/mw.6460.

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Neuropathic pain is a serious therapeutic problem. Current therapy is often ineffective, and the available drugs have serious side effects. For these reasons, the search for alternative therapeutic solutions is underway. Recent research on metabotropic receptors for glutamic acid (mGluR) gives great hope for the development of a new type of drug in the treatment of neuropathic pain. Particularly promising are antagonists of mGluR group I receptors. There are many studies demonstrating the efficacy of non-competitive mGlu1 and mGlu5 receptor antagonists in animal models of neuropathic pain. The
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Takeuchi, Koji, and Kenji Nagahama. "Animal Model of Acid-Reflux Esophagitis: Pathogenic Roles of Acid/Pepsin, Prostaglandins, and Amino Acids." BioMed Research International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/532594.

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Esophagitis was induced in rats within 3 h by ligating both the pylorus and transitional region between the forestomach and glandular portion under ether anesthesia. This esophageal injury was prevented by the administration of acid suppressants and antipepsin drug and aggravated by exogenous pepsin. Damage was also aggravated by pretreatment with indomethacin and the selective COX-1 but not COX-2 inhibitor, whereas PGE2showed a biphasic effect depending on the dose; a protection at low doses, and an aggravation at high doses, with both being mediated by EP1 receptors. Various amino acids also
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Aldughaim, Mohammed S., Fatimah Alsaffar, and Michael D. Barker. "Coupling of a Novel TIMP3 Peptide to Carboxypeptidase G2 for Pro-Drug Activation at the Tumour Site." Molecules 26, no. 3 (2021): 625. http://dx.doi.org/10.3390/molecules26030625.

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Broad-spectrum cytotoxic drugs have been used in cancer therapy for decades. However, their lack of specificity to cancer cells often results in serious side-effects, limiting efficacy. For this reason, antibodies have been used to attempt to specifically target cytotoxic drugs to tumours. One such approach is antibody-directed enzyme prodrug therapy (ADEPT) which uses a tumour-directed monoclonal antibody, coupled to an enzyme, to convert a systemically administered non-toxic prodrug into a toxic one only at the tumour site. Among the main drawbacks of ADEPT is the immunogenicity of the antib
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Conti, Paola, Marco De Amici, Giovanni Grazioso, et al. "Synthesis, Binding Affinity at Glutamic Acid Receptors, Neuroprotective Effects, and Molecular Modeling Investigation of Novel Dihydroisoxazole Amino Acids†." Journal of Medicinal Chemistry 48, no. 20 (2005): 6315–25. http://dx.doi.org/10.1021/jm0504499.

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Hirabara, Sandro Massao, Renata Gorjao, Adriana Cristina Levada-Pires, et al. "Host cell glutamine metabolism as a potential antiviral target." Clinical Science 135, no. 2 (2021): 305–25. http://dx.doi.org/10.1042/cs20201042.

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Abstract A virus minimally contains a nucleic acid genome packaged by a protein coat. The genome and capsid together are known as the nucleocapsid, which has an envelope containing a lipid bilayer (mainly phospholipids) originating from host cell membranes. The viral envelope has transmembrane proteins that are usually glycoproteins. The proteins in the envelope bind to host cell receptors, promoting membrane fusion and viral entry into the cell. Virus-infected host cells exhibit marked increases in glutamine utilization and metabolism. Glutamine metabolism generates ATP and precursors for the
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Pozdniakova, N. V., N. V. Gorokhovets, N. V. Gukasova, A. V. Bereznikova, and E. S. Severin. "New Protein Vector ApE1 for Targeted Delivery of Anticancer Drugs." Journal of Biomedicine and Biotechnology 2012 (2012): 1–5. http://dx.doi.org/10.1155/2012/469756.

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A new chimeric geneApE1encoding the receptor-binding domain of the humanalpha-fetoprotein fused to a sequence of 22 glutamic acid residues was constructed. A new bacterial producer strainE. coliSHExT7 ApE1 was selected for ApE1 production in a soluble state. A simplified method was developed to purify ApE1 from bacterial biomass. It was shown that the new vector protein selectively interacts with AFP receptors on the tumor cell surface and can be efficiently accumulated in tumor cells. In addition, ApE1 was shown to be stable in storage and during its chemical modification. An increased number
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Pangalos, M. N., A. L. Malizia, P. T. Francis, et al. "Effect of Psychotropic Drugs on Excitatory Amino Acids in Patients Undergoing Psychosurgery for Depression." British Journal of Psychiatry 160, no. 5 (1992): 638–42. http://dx.doi.org/10.1192/bjp.160.5.638.

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Samples of ventricular CSF were taken from 52 consecutive patients admitted for psychosurgery for intractable depression. Concentrations of asparagine, aspartate, glutamine, glutamic acid, and serine were determined. Glutamate and aspartate concentrations, implicated in excitotoxic brain damage, were not affected by various types of psychotropic drug treatment. Serine, a modulator of glutamate responses, was significantly elevated in samples from subjects receiving antidepressants. These subjects responded poorly to the operation. Psychotropic drugs are unlikely to be neurotoxic. Nevertheless,
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Aizawa, Sayaka, Takafumi Sakai та Ichiro Sakata. "Glutamine and glutamic acid enhance thyroid-stimulating hormone β subunit mRNA expression in the rat pars tuberalis". Journal of Endocrinology 212, № 3 (2012): 383–94. http://dx.doi.org/10.1530/joe-11-0388.

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Thyroid-stimulating hormone (TSH)-producing cells of the pars tuberalis (PT) display distinct characteristics that differ from those of the pars distalis (PD). The mRNA expression ofTSHβandαGSUin PT has a circadian rhythm and is inhibited by melatonin via melatonin receptor type 1; however, the detailed regulatory mechanism forTSHβexpression in the PT remains unclear. To identify the factors that affect PT, a microarray analysis was performed on laser-captured PT tissue to screen for genes coding for receptors that are abundantly expressed in the PT. In the PT, we found high expression of theK
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Meadus, WJ, R. MacInnis, and ME Dugan. "Prolonged dietary treatment with conjugated linoleic acid stimulates porcine muscle peroxisome proliferator activated receptor gamma and glutamine-fructose aminotransferase gene expression in vivo." Journal of Molecular Endocrinology 28, no. 2 (2002): 79–86. http://dx.doi.org/10.1677/jme.0.0280079.

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Peroxisome proliferator activated receptors (PPARs) represent a family of DNA binding proteins that are activated by a variety of dietary and endogenous fatty acids. The PPAR proteins are expressed throughout the body and are the target of a variety of lipidaemic and insulin sensitizing drugs. Conjugated linoleic acid (CLA) is a collective name for octadecadienoic acid isomers with conjugated double bonds, which can also act as ligands for some of the PPAR family. To gain better understanding of the long-term effects of PPAR activation, CLA was fed at 11 g/kg of feed for 45 days to castrated m
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Szpręgiel, Izabela, Danuta Wrońska, Michał Kmiecik, Sylwia Pałka, and Bogdan F. Kania. "Glutamic Acid Decarboxylase Concentration Changes in Response to Stress and Altered Availability of Glutamic Acid in Rabbit (Oryctolagus cuniculus) Brain Limbic Structures." Animals 11, no. 2 (2021): 455. http://dx.doi.org/10.3390/ani11020455.

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Glutamic acid decarboxylase (GAD) is an enzyme that catalyses the formation of γ-aminobutyric acid (GABA), the most important inhibitory neurotransmitter, from glutamic acid (Glu), which is considered the most important excitatory transmitter in the central and peripheral nervous systems. GAD is a key enzyme that provides a balance between Glu and GABA concentration. Hence, it can be assumed that if the GAD executes the synthesis of GABA from Glu, it is important in the stress response, and thus also in triggering the emotional states of the body that accompany stress. The aim of the study was
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Dissertations / Theses on the topic "Glutamic acid – Receptors – Effect of drugs on"

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Choi, Fiona Yeuk-Lun. "The effects of (RS)-MCPG on amphetamine-induced sensitization in neonatal rats." CSUSB ScholarWorks, 2006. https://scholarworks.lib.csusb.edu/etd-project/3181.

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The purpose of the study was to investigate the role of metabotropic glutamate receptors (mGluR) in the ontogeny of amphetamine-induced behavioral sensitization. Eleven-day-old rat pups were given five daily bilateral infusions of the mGluR antagonist, (RS)-methyl-4-carboxyphenylglycine (MCPG) followed by a systemic injection of amphetamine and locomotor activity was measured. It was hypothesized that rats receving amphetamine pretreatment and an amphetamine challenge would exhibit a significant increase in activity, indicating short-term behavioral sensitization. As predicted, repeated amphet
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2

Chawla, Aarti R. "CaMKII regulation of astrocytic glutamate uptake." Diss., 2016. http://hdl.handle.net/1805/10605.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Glutamate clearance by astrocytes is an essential part of physiological excitatory neurotransmission. Failure to adapt or maintain low levels of glutamate in the central nervous system is associated with multiple acute and chronic neurodegenerative diseases. The primary excitatory amino acid transporters (EAATs) in human astrocytes are EAAT1 and EAAT2 (GLAST and GLT-1 respectively in rodents). While the inhibition of a ubiquitously-expressed serine/threonine protein kinase, the calcium/calmodulindependent kinase (CaMKII) result
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Windisch, Kyle Allyson. "Role of group II metabotropic glutamate receptor subtype 2 (MGluR2) in appetitive and consummatory aspects of ethanol reinforcement." Thesis, 2014. http://hdl.handle.net/1805/6434.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Background: Group II metabotropic glutamate receptors (mGluR2/3) are predominately presynaptically located Gi/o coupled receptors that are highly expressed in the cortex, nucleus accumbens, amygdala, and hippocampus. Previous studies suggest that group II mGluRs are involved in regulating ethanol (EtOH) consumption and seeking following extinction (Backstrom and Hyytia, 2005; Kufahl, et al., 2011). The sipper tube model, which allows for procedural separation of seeking and consumption, was used to further clarify the role of mGluR2/
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Books on the topic "Glutamic acid – Receptors – Effect of drugs on"

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Turesson, Jenny. Oxygen chemoreflexes in fish with emphasis on Glutamatergic control mechanisms in the Medulla. Göteborg University, 2006.

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2

P, Ottersen O., Langmoen Iver Arne, and Gjerstad L, eds. The glutamate synapse as a therapeutical target: Molecular organization and pathology of the glutamate synapse. Elsevier, 1998.

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Direct and allosteric control of glutamate receptors. CRC Press, 1994.

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4

P, Ascher, Choi D. W, and Christen Yves, eds. Glutamate, cell death, and memory. Springer-Verlag, 1991.

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5

Dalip J.S. Sirinathsinghji (Editor) and Ray G. Hill (Editor), eds. NMDA antagonists as potential analgesic drugs (Progress in Inflammation Research). Birkhäuser Basel, 2002.

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(Editor), Bita Moghaddam, and Marina E. Wolf (Editor), eds. Glutamate and Disorders of Cognition and Motivation (Annals of the New York Academy of Sciences). New York Academy of Sciences, 2004.

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7

1955-, Hansson Elisabeth, Olsson Torsten 1937-, and Rönnbäck Lars, eds. On astrocytes and glutamate neurotransmission: New waves in brain information processing. Landes Bioscience, 1997.

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8

Stone, Trevor W. CNS Neurotransmitters and Neuromodulators: Glutamate. CRC, 1995.

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Stone, Trevor W. CNS Neurotransmitters and Neuromodulators: Dopamine. CRC-Press, 1996.

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Stone, Trevor W. CNS Neurotransmitters and Neuromodulators: Neuroactive Steroids (CNS Neurotransmitters & Neuromodulators). CRC, 1996.

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Book chapters on the topic "Glutamic acid – Receptors – Effect of drugs on"

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Parada-Turska, Jolanta, and Waldemar A. Turski. "Excitatory amino acid antagonists and memory: Effect of drugs acting at N- methyl-D-aspartate receptors in learning and memory tasks." In Amino Acids. Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-011-2262-7_90.

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