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Journal articles on the topic 'Glutaral – Physiological effect'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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1

Jeffrey, R. F., T. M. MacDonald та M. R. Lee. "A comparison of the renal actions of γ-l-glutamyl-l-dopa and γ-l-glutamyl-l-tyrosine in normal man". Clinical Science 74, № 1 (1988): 37–40. http://dx.doi.org/10.1042/cs0740037.

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1. The renal responses to the dipeptides γ-l-glutamyl-l-dopa (gludopa) and γ-l-glutamyl-l-tyrosine (glutyrosine) were compared when given intravenously in six normal male volunteers. 2. Gludopa is natriuretic and diuretic at a dose of 25 μg min−1 kg−1. At the same dose, glutyrosine had no effect on the volume or sodium content of the urine. 3. There was a 400-600-fold increase in urine dopamine output after gludopa; there was no conversion of glutyrosine to dopamine. 4. Gludopa significantly inhibited plasma renin activity, whereas with glutyrosine there was a non-significant increase. 5. Glud

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McKinney, R. A. "Physiological roles of spine motility: development, plasticity and disorders." Biochemical Society Transactions 33, no. 6 (2005): 1299–302. http://dx.doi.org/10.1042/bst0331299.

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The vast majority of excitatory connections in the hippocampus are made on dendritic spines. Both dendritic spines and molecules within the membrane are able to move, but the physiological role of these movements is unclear. In the developing brain, spines show highly dynamic behaviour thought to facilitate new synaptic connections. Dynamic movements also occur in adults but the role of this movement is unclear. We have studied the effects of the most important excitatory neurotransmitter, glutamat, and found receptor activation to enhance movement of molecules within the spine membrane. This

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Yassin, Maged M., and Mohammed S. Al-Najjar. "Hepatic and Renal Toxicity of Methamidophos in Male Domestic Rabbits: Physiological Aspect." Recent Advances in Biology and Medicine 6 (2020): 1. http://dx.doi.org/10.18639/rabm.2020.980000.

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Toxicity studies of methamidophos on the physiological aspects of mammalian organs are limited in the literature. This study aimed to assess hepatic and renal functions in response to a sublethal dose of methamidophos in male domestic rabbits. A daily dose of 1/10 LD50 methamidophos was given orally to rabbits for 6 weeks. Control animals were given distilled water. Blood samples were collected and analyzed weekly. Serum glucose and bilirubin were increased upon methamidophos intake versus control, with the significant change commenced from the second and fifth weeks, respectively. In general,

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Hervé, Mireille, Audrey Boniface, Stanislav Gobec, Didier Blanot та Dominique Mengin-Lecreulx. "Biochemical Characterization and Physiological Properties of Escherichia coli UDP-N-Acetylmuramate:l-Alanyl-γ-d-Glutamyl-meso- Diaminopimelate Ligase". Journal of Bacteriology 189, № 11 (2007): 3987–95. http://dx.doi.org/10.1128/jb.00087-07.

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ABSTRACT The UDP-N-acetylmuramate:l-alanyl-γ-d-glutamyl-meso-diaminopimelate ligase (murein peptide ligase [Mpl]) is known to be a recycling enzyme allowing reincorporation into peptidoglycan (murein) of the tripeptide l-alanyl-γ-d-glutamyl-meso-diaminopimelate released during the maturation and constant remodeling of this bacterial cell wall polymer that occur during cell growth and division. Mpl adds this peptide to UDP-N-acetylmuramic acid, thereby providing an economical additional source of UDP-MurNAc-tripeptide available for de novo peptidoglycan biosynthesis. The Mpl enzyme from Escheri

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Obeng-Gyasi, Emmanuel. "Cumulative Effects of Low-Level Lead Exposure and Chronic Physiological Stress on Hepatic Dysfunction—A Preliminary Study." Medical Sciences 8, no. 3 (2020): 30. http://dx.doi.org/10.3390/medsci8030030.

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Chronic physiological stress and hepatic injury were explored in this cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) 2007–2010. Lead exposure was measured using Blood Lead Levels (BLL), which were divided into quartiles of exposure based on the distribution within the database. Allostatic load (AL), a variable representing chronic physiological stress, was operationalized using ten clinical markers. The geometric mean values for markers of liver injury of interest (a) Aspartate Aminotransferase (AST), (b) Alanine Aminotransferase (ALT), (c)

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Hirota, Yoshihisa, and Yoshitomo Suhara. "New Aspects of Vitamin K Research with Synthetic Ligands: Transcriptional Activity via SXR and Neural Differentiation Activity." International Journal of Molecular Sciences 20, no. 12 (2019): 3006. http://dx.doi.org/10.3390/ijms20123006.

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Vitamin K is classified into three homologs depending on the side-chain structure, with 2-methyl-1,4-naphthoqumone as the basic skeleton. These homologs are vitamin K1 (phylloquinone: PK), derived from plants with a phythyl side chain; vitamin K2 (menaquinone-n: MK-n), derived from intestinal bacteria with an isoprene side chain; and vitamin K3 (menadione: MD), a synthetic product without a side chain. Vitamin K homologs have physiological effects, including in blood coagulation and in osteogenic activity via γ-glutamyl carboxylase and are used clinically. Recent studies have revealed that vit

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Amaral, Ana Lucia, Ederlan Souza Ferreira, Maraiza Aparecida Silva, Valdir Augusto Neves, and Aureluce Demonte. "The Vicilin protein (Vigna radiata L.) of mung bean as a functional food." Nutrition & Food Science 47, no. 6 (2017): 907–16. http://dx.doi.org/10.1108/nfs-05-2017-0089.

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Purpose The hypocholesterolemic activity of legume vicilins and the structural homology among mung bean, soybean and adzuki bean vicilins (8S) suggest that this protein may play a role in lipid metabolism. Thus, in the present study, the authors aim to isolate the mung bean vicilin and assess its in vitro effect on 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG CoAr), the enzyme responsible for endogenous cholesterol synthesis. Design/methodology/approach Chromatographic and electrophoretic characterization identified the molecular mass and polypeptide composition of mung bean vicilin. The hyd

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dos Santos Lacerda, Denise, Mariana Garbin de Almeida, Cláudia Teixeira, et al. "Biochemical and Physiological Parameters in Rats Fed with High-Fat Diet: The Protective Effect of Chronic Treatment with Purple Grape Juice (Bordo Variety)." Beverages 4, no. 4 (2018): 100. http://dx.doi.org/10.3390/beverages4040100.

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High-fat-diet (HFD) has been related to metabolic and cardiovascular diseases. Consumption of grapes and their byproducts containing phenolic compounds has been reported due to the benefits they produce for human health. The purpose of this study was to investigate the antioxidant and protective effect of chronic intake of purple grape juice on certain biochemical and physiological changes promoted by the consumption of HFD. Forty male rats were randomly divided into four groups to receive standard or HFD diet and/or conventional (CGJ) or organic grape juice (OGJ) for three months. Dietary int

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Gandra, Jefferson Rodrigues, Jose Esler de Freitas Junior, Milton Maturna Filho, Rafael Villela Barletta, Lenita Camargo Verdurico, and Francisco Palma Rennó. "Soybean oil and calcium salts of fatty acids as fat sources for Holstein dairy cows in transition period." Revista Brasileira de Saúde e Produção Animal 15, no. 1 (2014): 83–93. http://dx.doi.org/10.1590/s1519-99402014000100012.

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This study aimed to evaluate the effects of using different lipid sources in diets for dairy cows during the transition period and early lactation on productive performance and physiological parameters in Holstein cows. The cows were fed with the following diets: 1) control; 2) Refined soybean oil; 3) Calcium salts of unsaturated fatty acids (Megalac-E). Diets were formulated to meet the nutritional requirements of cows during the pre-partum and postpartum period. The experimental diets affected the dry matter intake, body weight, body condition score, and energy balance in the postpartum peri

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Murphy, Christopher, Evelyne Deplazes, Charles G. Cranfield, and Alvaro Garcia. "The Role of Structure and Biophysical Properties in the Pleiotropic Effects of Statins." International Journal of Molecular Sciences 21, no. 22 (2020): 8745. http://dx.doi.org/10.3390/ijms21228745.

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Statins are a class of drugs used to lower low-density lipoprotein cholesterol and are amongst the most prescribed medications worldwide. Most statins work as a competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGR), but statin intolerance from pleiotropic effects have been proposed to arise from non-specific binding due to poor enzyme-ligand sensitivity. Yet, research into the physicochemical properties of statins, and their interactions with off-target sites, has not progressed much over the past few decades. Here, we present a concise perspective on the role of sta

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Shand, J. H., D. W. West, and D. J. Flint. "Effects of growth hormone on cholesterol metabolism in the lactating rat mammary gland." Journal of Endocrinology 152, no. 3 (1997): 447–54. http://dx.doi.org/10.1677/joe.0.1520447.

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Lactating rats were treated for 48 h with bromocriptine (to inhibit prolactin release) or bromocriptine together with an antiserum to rat GH. Animals given the combined treatment were also supplemented concurrently with bovine GH (bGH) or human insulin-like growth factor-I (hIGF-I). The effects of these treatments on the activities of 3-methyl-3-glutaryl-CoA reductase (HMG-CoA reductase), acyl-CoA:cholesterol acyltransferase (ACAT) and neutral cholesteryl ester hydrolase (CEH) and on the microsomal concentrations of non-esterified and esterified cholesterol were measured. Lack of prolactin dec

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12

BOUMAN, Lena, Josiane SANCÉAU, Dany ROUILLARD та Brigitte BAUVOIS. "γ-Glutamyl transpeptidase expression in Ewing's sarcoma cells:up-regulation by interferons". Biochemical Journal 364, № 3 (2002): 719–24. http://dx.doi.org/10.1042/bj20011854.

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The genetic hallmark of Ewing's sarcoma family of tumours (ET) is the presence of the translocation t(11;22)(q24;q12), which creates the ET fusion gene, leading to cellular transformation. Five human γ-glutamyl transpeptidase (γ-GT) genes are located near the chromosomal translocation in ET. γ-GT is a major enzyme involved in glutathione homoeostasis. Five human cell lines representative of primary or metastatic tumours were investigated to study whether γ-GT alterations could occur at the chromosomal breaks and rearrangements in ET. As shown by enzymic assays and FACS analyses, all ET cell li

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13

Pascual Alonso, Isel, Laura Rivera Méndez, Mario E. Valdés-Tresanco, et al. "Biochemical evidences for M1-, M17- and M18-like aminopeptidases in marine invertebrates from Cuban coastline." Zeitschrift für Naturforschung C 75, no. 11-12 (2020): 397–407. http://dx.doi.org/10.1515/znc-2019-0169.

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AbstractMetallo-aminopeptidases (mAPs) control many physiological processes. They are classified in different families according to structural similarities. Neutral mAPs catalyze the cleavage of neutral amino acids from the N-terminus of proteins or peptide substrates; they need one or two metallic cofactors in their active site. Information about marine invertebrate’s neutral mAPs properties is scarce; available data are mainly derived from genomics and cDNA studies. The goal of this work was to characterize the biochemical properties of the neutral APs activities in eight Cuban marine invert

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14

Agius, L. "Control of glucokinase translocation in rat hepatocytes by sorbitol and the cytosolic redox state." Biochemical Journal 298, no. 1 (1994): 237–43. http://dx.doi.org/10.1042/bj2980237.

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In rat hepatocytes cultured in 5 mM glucose, glucokinase activity is present predominantly in a bound state, and during permeabilization of the cells with digitonin in the presence of Mg2+ less than 20% of glucokinase activity is released. However, incubation of hepatocytes with a higher [glucose] [concn. giving half-maximal activation (A50) 15 mM] or with fructose (A50 50 microM) causes translocation of glucokinase from its Mg(2+)-dependent binding site to an alternative site [Agius and Peak (1993) Biochem. J. 296, 785-796]. A comparison of various substrates showed that sorbitol (A50 8 micro

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15

Rahmah, Windya Nazmatur. "Review: Pengaruh Pemberian Ekstrak Propoelix terhadap Morfologi Motilitas dan Jumlah Sel Spermatozoa Tikus Wistar Jantan yang Diinduksi oleh Monosodium Glutamat." Borneo Journal of Medical Laboratory Technology 3, no. 1 (2020): 197–201. http://dx.doi.org/10.33084/bjmlt.v3i1.1910.

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Giving MSG can reduce the morphological quality, motility, and count of spermatozoa. Propoelix extract as an antioxidant is evidently capable of a non-enzymatic radical scavenger. This research aims at evaluating the effect of propoelix extract administration on sperm quality of MSG-induced male Wistar rats. Employing the post the only control group design, 18 rats aged 3 months were divided into 3 random groups, weighing ±250 gram. Propoelix extract was given orally for 21 days and on 22 days, cauda epididymis until the ampulla of vas deferens was cut in a glass jar that has been given 0,5 cc

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16

Cruz, Rebecca Espírito Santo da, Fernando Melo Rocha, Cassius Vinícius Barbosa Sena, et al. "Effects of age and sex on blood biochemistry of dorper lambs." Semina: Ciências Agrárias 38, no. 5 (2017): 3085. http://dx.doi.org/10.5433/1679-0359.2017v38n5p3085.

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The purpose of this study was to evaluate the physiological variations and influence of age group and sex on biochemical variables of 32 male and female Dorper sheep at the age of 15 to 121 days. Four blood samples were collected from each animal, at monthly intervals, totaling 128 samples. Biochemical variables determined in each sample were total protein (TP), albumin (ALB), globulin (GLB), albumin/globulin ratio (A/G), glucose (GLU), triglycerides (TG), total cholesterol (tCHOL), high density cholesterol carrying lipoproteins (HDL-C), low density cholesterol carrying lipoproteins (LDL-C), v

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Premi, Michele, Matteo Mezzetti, Giulia Ferronato, et al. "Changes of Plasma Analytes Reflecting Metabolic Adaptation to the Different Stages of the Lactation Cycle in Healthy Multiparous Holstein Dairy Cows Raised in High-Welfare Conditions." Animals 11, no. 6 (2021): 1714. http://dx.doi.org/10.3390/ani11061714.

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Here, we tested the changes occurring in several plasma analytes during different stages of the lactation cycle of high welfare raised multiparous Holstein cows, and provided reference intervals (RI) for plasma analytes concentrations. Eleven high-welfare farms (HWF) located in Northern Italy were selected and their herds used to recruit 361 clinically healthy cows undergoing the dry (from −30 to −10 days from real calving; DFC), the postpartum (from 3 to 7 DFC), the early lactation (from 28 to 45 DFC) and the late lactation phases (from 160 to 305 DFC). Cows affected by subclinical diseases (

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18

Sakr, Hussein F., Fahaid H. Al-Hashem, Waffaa M. Hassab El-Naby, et al. "Preventive roles of swimming exercise and pioglitazone treatment on hepatic dysfunction in a rat model of metabolic syndrome." Canadian Journal of Physiology and Pharmacology 92, no. 2 (2014): 162–70. http://dx.doi.org/10.1139/cjpp-2013-0043.

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Pioglitazone (Pio) and swimming exercise (SE) are insulin sensitisers. This investigation was suggested because of the significant side effects associated with Pio treatment in metabolic syndrome (MetS). This study was, therefore, designed to investigate the preventive role of Pio treatment and SE in terms of efficiency and pathological changes in MetS in a rat model. Sixty male Sprague–Dawley rats were distributed equally among 6 groups: (i) control group (C), (ii) exercised control group (C+E), (iii) Pio-treated control group (C+Pio), (iv) group with MetS, (v) group with MetS treated with Pi

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Duncan, Alan J., and John A. Milne. "Effects of oral administration of brassica secondary metabolites, allyl cyanide, allyl isothiocyanate and dimethyl disulphide, on the voluntary food intake and metabolism of sheep." British Journal of Nutrition 70, no. 2 (1993): 631–45. http://dx.doi.org/10.1079/bjn19930154.

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Glucosinolates, such as sinigrin, and S-methyl cysteine sulphoxide (SMCO), which are found in forage brassica species have been implicated in the low intakes observed among lambs consuming such diets. To test both the individual and interactive effects of these compounds in sheep, all combinations of the sinigrin breakdown products, allyl cyanide (ACN) and allyl isothiocyanate (AITC; 10 mmol/d), and the SMCO metabolite dimethyl disulphide (DMDS; 25 mmol/d) were orally administered twice daily for 5 weeks to forty sheep offered dried grass pelletsad lib. As well as measuring voluntary food inta

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McCormack, J. G. "Characterization of the effects of Ca2+ on the intramitochondrial Ca2+-sensitive enzymes from rat liver and within intact rat liver mitochondria." Biochemical Journal 231, no. 3 (1985): 581–95. http://dx.doi.org/10.1042/bj2310581.

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The regulatory properties of the Ca2+-sensitive intramitochondrial enzymes (pyruvate dehydrogenase phosphate phosphatase, NAD+-isocitrate dehydrogenase and 2-oxoglutarate dehydrogenase) in extracts of rat liver mitochondria appeared to be essentially similar to those described previously for other mammalian tissues. In particular, the enzymes were activated severalfold by Ca2+, with half-maximal effects at about 1 microM-Ca2+ (K0.5 value). In intact rat liver mitochondria incubated in a KCl-based medium containing 2-oxoglutarate and malate, the amount of active, non-phosphorylated, pyruvate de

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Ruvini, Liyanage, Naoto Hashimoto, Kyu-Ho Han, et al. "Some bovine proteins behave as dietary fibres and reduce serum lipids in rats." British Journal of Nutrition 97, no. 5 (2007): 898–905. http://dx.doi.org/10.1017/s0007114507665209.

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We examined the physiological importance of bovine dietary proteins in rats fed diets prepared from bovine Achilles' tendons and arteries. Rats were fed for 4 weeks, with a 20 % casein diet (CON), in comparison with two diets containing 15 % casein and 5 % of either bovine Achilles' tendon (AC) or artery (AR) protein preparations. The serum total cholesterol concentration and non-HDL-cholesterol level in the AR-fed group were significantly lower (P < 0·05) than those in the CON-fed group at the end of the 4-week feeding period. The hepatic mRNA were measured, and the hydroxyl methyl glutary

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Le, Thu H., Michael I. Oliverio, Hyung-Suk Kim та ін. "A γGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice". Physiological Genomics 18, № 3 (2004): 290–98. http://dx.doi.org/10.1152/physiolgenomics.00120.2003.

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To understand the physiological role of angiotensin type 1 (AT1) receptors in the proximal tubule of the kidney, we generated a transgenic mouse line in which the major murine AT1 receptor isoform, AT1A, was expressed under the control of the P1 portion of the γ-glutamyl transpeptidase (γGT) promoter. In transgenic mice, this promoter has been shown to confer cell-specific expression in epithelial cells of the renal proximal tubule. To avoid random integration of multiple copies of the transgene, we used gene targeting to produce mice with a single-copy transgene insertion at the hypoxanthine

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Seok, Jin Kyung, Eun-Hee Hong, Gabsik Yang, et al. "Oxidized Phospholipids in Tumor Microenvironment Stimulate Tumor Metastasis via Regulation of Autophagy." Cells 10, no. 3 (2021): 558. http://dx.doi.org/10.3390/cells10030558.

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Oxidized phospholipids are well known to play physiological and pathological roles in regulating cellular homeostasis and disease progression. However, their role in cancer metastasis has not been entirely understood. In this study, effects of oxidized phosphatidylcholines such as 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC) on epithelial-mesenchymal transition (EMT) and autophagy were determined in cancer cells by immunoblotting and confocal analysis. Metastasis was analyzed by a scratch wound assay and a transwell migration/invasion assay. The concentrations of POVPC and

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Schmidt, Ana Paula, Joana Piagetti Noschang, Nathaly Ana Carpinelli, et al. "Evaluation of biochemical profile and rumen fluid parameters of sheep supplemented with Saccharomyces cerevisiae and subjected to an abrupt diet change." Semina: Ciências Agrárias 41, no. 6supl2 (2020): 3311–22. http://dx.doi.org/10.5433/1679-0359.2020v41n6supl2p3311.

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This study examines rumen-fluid parameters and the biochemical profile of feedlot sheep supplemented with a commercial product composed of yeast culture and enzymatically hydrolyzed yeast during an abrupt change of diet. Eight sheep at 30 months of age, with an average weight of 40.2 ± 3.4 kg, were housed in individual stalls where they received the same diet twice daily, which was formulated according to the National Research Council [NRC] (2007). The animals were divided into two groups, namely, supplemented with Saccharomyces cerevisiae (SG, n = 4) and control (CG, n = 4). The experiment co

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Whitfield, John B., Lucía Colodro-Conde, Paul R. H. J. Timmers, Peter K. Joshi, Grant W. Montgomery, and Nicholas G. Martin. "Comparison of Familial, Polygenic and Biochemical Predictors of Mortality." Twin Research and Human Genetics 23, no. 6 (2020): 307–15. http://dx.doi.org/10.1017/thg.2020.89.

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AbstractMortality risk is known to be associated with many physiological or biochemical risk factors, and polygenic risk scores (PRSs) may offer an additional or alternative approach to risk stratification. We have compared the predictive value of common biochemical tests, PRSs and information on parental survival in a cohort of twins and their families. Common biochemical test results were available for up to 13,365 apparently healthy men and women, aged 17−93 years (mean 49.0, standard deviation [SD] 13.7) at blood collection. PRSs for longevity were available for 14,169 study participants a

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R.K. Singh, Anil Kumar. "CCl Induced Hepatotoxicity and It's Recovery by Leaves and Seed Extract of 4Cassia Fistula." Universities' Journal of Phytochemistry and Ayurvedic Heights 2, no. 29 (2020): 50–56. http://dx.doi.org/10.51129/ujpah-2020-29-2(8).

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Abstract-Fabaceae (Caesalpiniaceae)IntroductionIndia is one of the richest countries among the world in resources of medicinal plants in various sytems 1,2like Ayurveda, Siddha, Unani, etc. The treatment of patients with these medicinal plants is increasing 3from previous to till dates. The all medicinal plants contain several biochemical or chemical active substances that show a definite physiological action on human or animal body while applying as -The present communication is based on herb, namely, Cassia fistula. belonging to family for the prevention of intoxication induced with a sublet

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NICHOLAS, Ben, Peter SMETHURST, Elisabetta VERDERIO, Richard JONES, and Martin GRIFFIN. "Cross-linking of cellular proteins by tissue transglutaminase during necrotic cell death: a mechanism for maintaining tissue integrity." Biochemical Journal 371, no. 2 (2003): 413–22. http://dx.doi.org/10.1042/bj20021949.

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Tissue transglutaminase (tTG) is a Ca2+-dependent enzyme which cross-links proteins via ε(γ-glutamyl)lysine bridges. There is increasing evidence that tTG is involved in wound repair and tissue stabilization, as well as in physiological mechanisms leading to cell death. To investigate the role of this enzyme in tissue wounding leading to loss of Ca2+ homoeostasis, we initially used a model involving electroporation to reproduce cell wounding under controlled conditions. Two cell models were used whereby tTG expression is regulated either by antisense silencing in ECV 304 cells or by using tran

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Мавзютов, А. Р., Р. Р. Гарафутдинов, А. Р. Габдрахманова, И. М. Салахов, and И. Д. Тупиев. "Effect of Sinorhizobium meliloti lipopolysaccharide on blood cell composition in experiment." ZHurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia», no. 3() (June 27, 2019): 20–28. http://dx.doi.org/10.25557/0031-2991.2019.03.20-28.

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Липолисахариды (ЛПС, эндотоксины) грамотрицательных бактерий обладают выраженной биологической активностью, в том числе терапевтической, однако для S. meliloti таких данных нет. Цель работы - экспериментальное изучение гемопоэтической активности 4 фракций липополисахаридов, выделенных из S. meliloti, при индуцированном иммунодефиците у мышей. Методика. Сформировано 7 групп лабораторных мышей (по 10 особей в каждой): 1-я группа - интактные (контроль 1), 2-я - 7-я группа - мыши с иммунодефицитным состоянием, индуцированным однократным внутрибрюшинным введением циклофосфамида. Через 1 сут после м

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Park, Chan B., Sun Bok Lee, and Dewey D. Y. Ryu. "l-Pyroglutamate Spontaneously Formed from l-Glutamate Inhibits Growth of the Hyperthermophilic Archaeon Sulfolobus solfataricus." Applied and Environmental Microbiology 67, no. 8 (2001): 3650–54. http://dx.doi.org/10.1128/aem.67.8.3650-3654.2001.

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ABSTRACT Identification of physiological and environmental factors that limit efficient growth of hyperthermophiles is important for practical application of these organisms to the production of useful enzymes or metabolites. During fed-batch cultivation of Sulfolobus solfataricus in medium containing l-glutamate, we observed formation of l-pyroglutamic acid (PGA). PGA formed spontaneously from l-glutamate under culture conditions (78°C and pH 3.0), and the PGA formation rate was much higher at an acidic or alkaline pH than at neutral pH. It was also found that PGA is a potent inhibitor of S.

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Lisbôa, Júlio Augusto Naylor, Tiago Torrecillas Sturion, Mayara Cardoso dos Anjos, and Karina Keller Marques da Costa Flaiban. "Passive Transfer of Immunity and Serum Proteinogram during the First 35 Days of Age in Nelore Calves Conceived Naturally or Through In Vitro Fertilization." Acta Scientiae Veterinariae 44, no. 1 (2018): 7. http://dx.doi.org/10.22456/1679-9216.81297.

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Background: Some reports indicate that calves produced by in vitro fertilization (IVF) may have excessive birth weights, increasing the rates of dystocia. Prolonged labor can cause the birth of lethargic calves that slowly ingest colostrum; this may compromise the intestinal absorption of immunoglobulins. Although the number of beef calves produced by IVF is high in Brazil, there have been few physiological studies examining the neonatal period in such cases. The aim of this study was to evaluate the passive transfer of immunity, and characterize the variation in serum protein concentrations,

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Hammen, T., H. Stefan, and B. Tomandl. "The role of clinicalin vivo1H–MR spectroscopy in the evaluation of epilepsies." Spectroscopy 16, no. 3-4 (2002): 297–306. http://dx.doi.org/10.1155/2002/842843.

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1H–MRS which is a noninvasive method in detecting various brain metabolites containing N–acetylaspartat (NAA), cholin (Cho), creatin (Cr) GABA and glutamat has become a diagnostic tool for assessing a number of diseases of the central nervous system particularly including epilepsies and brain tumours. 1H–MRS plays an increasing role in the evaluation of epilepsies and their treatment schedules today. NAA is accepted as a marker of neuronal/axonal density and viability. It’s detailed physiological role is yet unknown. A loss or decrease of NAA is seen in diseases which are associated with loss

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Montoya Navarrete, Ana Luisa, Teódulo Quezada Tristán, Samuel Lozano Santillán, et al. "Effect of age, sex, and body size on the blood biochemistry and physiological constants of dogs from 4 wk. to > 52 wk. of age." BMC Veterinary Research 17, no. 1 (2021). http://dx.doi.org/10.1186/s12917-021-02976-w.

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Abstract Background Blood biochemistry and reference intervals help to differentiate between healthy and ill dogs as well as to provide information for the prognosis, evaluation, and monitoring; however, these intervals are often obtained from adult animals. It is essential to understand that puppies and adults are physiologically different, which justifies the need to obtain age-specific biochemical reference intervals. The aim of this research was to assess the potential effect of age, sex, body size, and their interaction on routine biochemical analytes and physiological constants (body tem

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Hao, Zhenyu, Dayun Jin, Xuejie Chen, Leon J. Schurgers, Darrel W. Stafford, and Jian-Ke Tie. "Gamma-glutamyl carboxylase mutations differentially affect the biological function of vitamin K-dependent proteins." Blood, August 12, 2020. http://dx.doi.org/10.1182/blood.2020006329.

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Gamma-glutamyl carboxylase (GGCX) is an integral membrane protein that catalyzes posttranslational carboxylation of a number of vitamin K-dependent (VKD) proteins involved in a wide variety of physiological processes, including blood coagulation, vascular calcification, and bone metabolism. Naturally occurring GGCX mutations are associated with multiple distinct clinical phenotypes. However, the genotype-phenotype correlation of GGCX remains elusive. Here, we systematically examined the effect of all naturally occurring GGCX mutations on the carboxylation of three structure-function distinct V

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Erdoğan, Ramazan. "Investigation of the Effects of Volleyball Training on Athletes' Liver Enzymes and Muscle Damage Markers." Journal of Pharmaceutical Research International, March 6, 2021, 1–6. http://dx.doi.org/10.9734/jpri/2021/v33i831207.

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Aims: It is seen that regular exercises cause physiological changes in the organism. The effects of such a training are not known especially on liver enzymes and muscle damages. In this regard, this study aimed to determine the effects of long-term volleyball training on athletes’ indicators of liver enzymes and muscle damages. Methodology: 20 male volunteer athletes in volleyball branch participated in the study. In the study, a 12-week training program was applied to the athletes four days a week, and one day intended for conditioning training in each week. Blood samples were received

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Riquelme, José Belarmino, Victoria Matilde Cazanga, Cristina Judith Palma, Linda Krissy Castillo, and Rubén Pérez. "CLINICAL AND HEMATOLOGICAL CHANGES IN SHEEP INDUCED BY Escherichia coli LIPOPOLYSACCHARIDE." Arquivos de Ciências Veterinárias e Zoologia da UNIPAR 21, no. 2 (2018). http://dx.doi.org/10.25110/arqvet.v21i2.2018.6532.

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Organic response to infection is characterized by a systemic reaction known as acute phase response (APR). In order to know the effect of the administration of Escherichia coli lipopolysaccharide (LPS) on physiological, hematological and biochemical variables, 10 sheep weighing 45 ± 5 kg were divided in two groups: Experimental group treated with 3 doses of 1 μg.kg-1 LPS and control group treated with saline solution (SS) at the same frequency as experimental group. Body temperature (BT°), heart rate (HR) and respiratory rate (RR) were monitored. Blood samples for hemogram and enzyme activity

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Di Majo, Danila, Gabriella Schiera, Valentina Contrò, et al. "Biochemical adaptations in middle-distance runners: an assessment of blood and anthropometric parameters." Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale 87, no. 2 (2014). http://dx.doi.org/10.4081/jbr.2014.4713.

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In order to understand the mechanism underlying the physiological adaptation of purely aerobic workout, we investigated the effect of 2 months of training on nine males (17-22 year-old) middle distance running agonistic athletes. Blood sample was collected in the morning to analyze: hematological parameters, lipid profile, liver function enzymes [glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, gamma-glutamyl transferase (γ-GT)] and skeletal and myocardial markers of muscle damage [creatin kinase (CK) and creatin kinase MB (CK-MB)]. Endurance training, as it implies high o

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Sun, Liting, Lu Chen, Yanwen Jiang, et al. "Metabolomic profiling of ovary in mice treated with FSH using ultra performance liquid chromatography/mass spectrometry." Bioscience Reports 38, no. 6 (2018). http://dx.doi.org/10.1042/bsr20180965.

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The growth and development of follicles are a very complex physiological process that is regulated by endocrine, autocrine and paracrine mechanisms. The effect of small molecules in follicular microenvironment on follicular growth and development has not been clearly analyzed. In the present study, the metabolic changes in ovaries of FSH-stimulated mice were investigated. Metabolomic profiling of ovary stimulated by FSH were analyzed by ultra-performance liquid chromatography/mass spectrometry and characterized by principal components analysis and orthogonal partial least squares discriminant

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Trimboli, Francesca, Ippolito De Amicis, Antonio Di Loria, Carlotta Ceniti, and Augusto Carluccio. "Reference Ranges for Hematological and Biochemical Profile of Martina Franca Donkeys." Frontiers in Veterinary Science 7 (December 18, 2020). http://dx.doi.org/10.3389/fvets.2020.602984.

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The Martina Franca donkey (MFd) is one of the largest Italian donkey breeds, considered as endangered breed. To support the conservation strategies, knowledge about the physiologic hematological parameters of MFds is needed. The aims of the study were to determine reference value for hematological and major serum parameters in a population of healthy MFds and to estimate the influence of age on these parameters. Eighty-one clinically healthy MFds (17 males and 64 females) in different ages were enrolled: group A (foals, n° 16, animals &lt; 1 year old) group B (young animals, n° 36, from 1

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