Relevant bibliographies by topics / Glutathion-S-transferase [GST]

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Glutathion-S-transferase [GST]'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Glutathion-S-transferase [GST]"

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Nurkhasanah, Laela Hayu Nurani, and Zainur Rahman Hakim. "Effect of rosella (Hibiscus sabdariffa L) extract on glutathione-S-transferase activity in rats." Tropical Journal of Pharmaceutical Research 16, no. 10 (2017): 2411–16. http://dx.doi.org/10.4314/tjpr.v16i10.14.

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Purpose: To determine the effect of rosella (Hibiscus sabdariffa L) extract on glutathione-S-trasferase (GST) activity and its hepatoprotective effect.Methods: A total of 25 rats were divided randomly into 5 groups (5 rats per group). Group I served as the baseline, group II was the negative control group, while groups III, IV and V were treated with rosella extract at doses of 10, 50 and 100 mg /kg /day, respectively for 35 days. On day 36, the animals were given a single dose of dimethyl benz(a)anthracene (DMBA) orally. After one week, blood was taken from the sinus orbitalis for measurement
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Afifi, Mohamed, Omar A. Almaghrabi, and Naif Mohammed Kadasa. "Ameliorative Effect of Zinc Oxide Nanoparticles on Antioxidants and Sperm Characteristics in Streptozotocin-Induced Diabetic Rat Testes." BioMed Research International 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/153573.

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The present study investigated the impact of zinc oxide nanoparticles (ZnONPs) on the oxidative status and sperm characteristics in diabetic rat testicular tissue. Forty male albino rats were used in this study; 10 of them served as a control and 30 rats were injected with a single dose (100 mg/kg) of streptozotocin intraperitoneally. They were subdivided into diabetic, diabetic + ZnONPs (10 mg/kg B.W.), and diabetic and cotreated with ZnONPs + insulin groups. The sperm count and motility were assessed. The activity and mRNA expression of superoxide dismutase (SOD), catalase (CAT), glutathione
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Grubisa, Ivana, Petar Otasevic, Nebojsa Despotovic, Velimir Dedic, Jelena Milasin, and Nada Vucinic. "Genetic polymorphism of glutathion S-transferase P1 (GSTP1) Ile105Val and susceptibility to atherogenesis in patients with type 2 diabetes mellitus." Genetika 45, no. 1 (2013): 227–36. http://dx.doi.org/10.2298/gensr1301227g.

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One of the characteristics of type 2 diabetes mellitus (T2DM) is the state of persistent oxidative stress (OS) that has been implicated in the pathogenesis of diseases such is atherosclerosis mainly through chronic hyperglycemia that stimulates production of reactive oxygen species (ROS) and increases OS. Glutathione S-transferase P1 (GSTP1) is a member of the cytosolic GST superfamily. It plays an important role in neutralizing OS as an enzyme. Also, it participates in regulation of stress signaling and protects cells against apoptosis via its noncatalytic ligand-binding activity. GSTP1 Ile10
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Syafitri, Syafitri. "PENGARUH PEMBERIAN Curcuma xanthoriza Roxb TERHADAP PERBAIKAN KERUSAKAN SEL HEPAR." Jurnal Ilmu Kedokteran dan Kesehatan 6, no. 3 (2019): 236–41. http://dx.doi.org/10.33024/jikk.v6i3.2192.

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Hepatitis kronis merupakan salah satu masalah besar yang dihadapi dunia termasuk di Indonesia. Hepatitis kronis dapat berkembang menjadi progresif yang menjadi awal terjadinya sirosis hati dan akhirnya kanker hati pada 20-30 % kasus. Hepatitis secara patofisiologi akan menyebabkan kerusakan sel pada hati. Hepatoprotektor adalah suatu senyawa obat yang dapat memberikan perlindungan pada hati dari kerusakan yang ditimbulkan oleh racun, obat, dan lain-lain. Temulawak diteliti dapat berperan sebagai hepatoprotektor. Temulawak adalah salah satu tanaman herbal yang dapat dijadikan alternatif pengoba
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Yang, Mon-Yuan, Tung-Wei Hung, Chau-Jong Wang, and Tsui-Hwa Tseng. "Inhibitory Effect of Nelumbo nucifera Leaf Extract on 2-Acetylaminofluorene-induced Hepatocarcinogenesis Through Enhancing Antioxidative Potential and Alleviating Inflammation in Rats." Antioxidants 8, no. 9 (2019): 329. http://dx.doi.org/10.3390/antiox8090329.

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Leaf extract of Nelumbo nucifera (NLE) has been demonstrated to possess anti-atherosclerosis, improve alcohol-induced steatohepatitis, prevent high-fat diet-induced obesity, and inhibit the proliferation and metastasis of human breast cancer cells. This study determines the chemopreventive role of NLE against 2-acetylaminofluorene (AAF)-induced hepatocellular carcinoma (HCC) in rats. AAF was used to induce hepatocarcinogenesis in rats through genetic and nongenetic effects. After administration for 12 weeks, NLE (0.5–2%) supplementation orally inhibited AAF (0.03%)-induced hepatic fibrosis whi
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Çelık, Veysel Kenan, Zeynep Deniz Şahın, İsmail Sari, and Sevtap Bakir. "Comparison of Oxidant/Antioxidant, Detoxification Systems in Various Tissue Homogenates and Mitochondria of Rats with Diabetes Induced by Streptozocin." Experimental Diabetes Research 2012 (2012): 1–5. http://dx.doi.org/10.1155/2012/386831.

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Objective. Oxidative stress is considered to be the main factor in the development of diabetic complications and tissue injury. our objective was to investigate and compare the oxidant/antioxidant conditions and detoxification mechanisms of the liver, lung, kidney, cardiac tissues, and mitochondria of rats with diabetes induced by streptozocin (STZ).Methods. Rats with diabetes induced by streptozocin were anesthetized by administering 90 mg/kg ketamine hydrochloride and 3 mg/kg xylazine hydrochloride. Thoracic cavities were incised open; liver, lung, kidney, and cardiac tissues were removed an
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Paret, Aurelie, Delphine Rolland, Vincent Ribrag, Bertrand Coiffier, and Catherine Thieblemont. "Inhibition of GSTpi Activity Increases the Sensitivity of MCL Cell Lines to Cisplatin, Cytarabin and Bortezomib, but Not Doxorubicin." Blood 106, no. 11 (2005): 2806. http://dx.doi.org/10.1182/blood.v106.11.2806.2806.

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Abstract Preliminary data suggest drug resistance plays a major role in mantle cell lymphoma (MCL) and is linked to the aberrant expression of molecules such as Glutathion S-Transferase pi (GST pi) that catalyzes the nuclear conjugation of a broad variety of reactive electrophiles to the glutathion. We investigated in vitro the effect of the inhibition of GSTpi activity on the chemosensitivity of MCL cell lines by inhibiting the nuclear transport of GSTpi with Agaricus bisporus leptine (ABL). Methods. Four MCL cell lines (Granta, NCEB, REC and UPN1) were analyzed for GSTP1 transcript expressio
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Oda, Atsushi, Hans D. Ochs, Brian J. Druker, et al. "Collagen Induces Tyrosine Phosphorylation of Wiskott-Aldrich Syndrome Protein in Human Platelets." Blood 92, no. 6 (1998): 1852–58. http://dx.doi.org/10.1182/blood.v92.6.1852.

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Abstract Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT) are caused by mutations of the WAS protein (WASP) gene. All hematopoietic stem cell-derived lineages, including platelets, express WASP. Platelets from WAS patients are smaller than their normal counterparts and defects in platelet aggregation and actin polymerization have been reported. To determine if WASP is important for normal platelet function, we examined its role in signal transduction. We found that collagen but not thrombopoietin or thrombin induces a rapid and robust increase in tyrosine phosphorylation of p
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Oda, Atsushi, Hans D. Ochs, Brian J. Druker, et al. "Collagen Induces Tyrosine Phosphorylation of Wiskott-Aldrich Syndrome Protein in Human Platelets." Blood 92, no. 6 (1998): 1852–58. http://dx.doi.org/10.1182/blood.v92.6.1852.418k36_1852_1858.

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Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT) are caused by mutations of the WAS protein (WASP) gene. All hematopoietic stem cell-derived lineages, including platelets, express WASP. Platelets from WAS patients are smaller than their normal counterparts and defects in platelet aggregation and actin polymerization have been reported. To determine if WASP is important for normal platelet function, we examined its role in signal transduction. We found that collagen but not thrombopoietin or thrombin induces a rapid and robust increase in tyrosine phosphorylation of platelet-a
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10

Schön, M. R., N. Akkoc, W. Heil та ін. "Die Bestimmung der α-Glutathion-S-Transferase-Konzentration zur Beurteilung hepatozellulärer Ischämieschäden im Vergleich zu GOT, GPT und LDH im Lebertransplantationsmodell." LaboratoriumsMedizin 23, № 4 (1999): 218–27. http://dx.doi.org/10.1515/labm.1999.23.4.218.

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Dissertations / Theses on the topic "Glutathion-S-transferase [GST]"

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Flamant, Cyril. "Mucoviscidose et système oxydant / anti-oxydant : étude de gènes modificateurs." Paris 6, 2005. http://www.theses.fr/2005PA066297.

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Ivanoff, Nathalie. "Liposomes multilamellaires vecteurs de l'antigene rsm28 gst (schistosoma mansoni 28 kda glutathion s-transferase recombinante ) pour une vaccination par voie muqueuse." Lille 2, 1996. http://www.theses.fr/1996LIL2T008.

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OULDELHKIM, MOSTAFA. "Role eventuel de la glutathion-s-transferase type placentaire (gst-p) pendant l'hepatocancerogenese chimique : etude in vivo et en culture de cellules." Paris 7, 1990. http://www.theses.fr/1990PA077075.

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Depuis une vingtaine d'annees, de nombreux travaux ont demontre le role du phenobarbital (pb) comme promoteur dans le processus de cancerogenese hepatique in vivo. Le pb ainsi utilise provoque des modifications phenotypiques spectaculaires au niveau du foie de rat. La gst-p qui est une isoenzyme (sous-unite 7) des glutathion-s-transferases totales, a ete impliquee dans le processus d'hepatocancerogenese. L'expression de ce nouveau marqueur nous a semble interessante pour apprehender les mecanismes cellulaires et moleculaires de l'hepatocancerogenese chimique. A titre de reference, nous avons c
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4

Landais, Florence. "Les glutathion s-transférases : étude de la GST mu chez les sujets sains et chez les alcooliques cirrhotiques." Bordeaux 2, 1990. http://www.theses.fr/1990BOR23023.

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Zorman, Sarah. "Nouveau regard sur la signalisation AMPK : multiples fonctions de nouveaux interacteurs." Phd thesis, Université de Grenoble, 2013. http://tel.archives-ouvertes.fr/tel-00877237.

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La protéine kinase activée par AMP (AMPK) est un senseur et régulateur central de l'état énergétique cellulaire, mais ces voies de signalisation ne sont pour le moment que partiellement comprises. Deux criblages non-biaisés pour la recherche de partenaires d'interaction et de substrats d'AMPK ont précédemment été réalisés dans le laboratoire. Ces derniers ont permis l'identification de plusieurs candidats (protéines), mais leur rôle fonctionnel et physiologique n'était pas encore établi. Ici nous avons caractérisé la fonction de la relation entre AMPK et quatre partenaires d'interaction : glut
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