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1

Silivanova, E. A., P. A. Shumilova, and M. A. Levchenko. "Activities of detoxifying enzymes in adults of houseflies Musca domestica L. selected with chlorfenapyr." Biomics 12, no. 4 (2020): 492–503. http://dx.doi.org/10.31301/2221-6197.bmcs.2020-43.

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In insects, biochemical mechanisms of insecticide resistance base on increasing of activities of main detoxyfying enzymes – monooxygenases, nonspesific esterases, and glutathion-S-transferases. Currently, the progress of resistance development and the degree of contributing enzymes to resistance in insects have been studied for certain insecticides. The goal of this study was to assess activities of monooxygenase, carboxylesterase, glutathione-S-transferase, and alkaline phosphatase in females and males housefly Musca domestica in the second, fourth, sixth, eighth and tenth generations of the
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2

Ito, Mika, Satoshi Shuto, Yoshihiro Ito, and Hiroshi Abe. "Development of Molecular Probe Targeting on Glutathion Transferase." Journal of Synthetic Organic Chemistry, Japan 72, no. 7 (2014): 822–31. http://dx.doi.org/10.5059/yukigoseikyokaishi.72.822.

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3

Tison, F., C. Coutelle, P. Henry, and A. Cassaigne. "Glutathion s-transferase (class ?) phenotype in Parkinson's disease." Movement Disorders 9, no. 1 (1994): 117–18. http://dx.doi.org/10.1002/mds.870090128.

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4

Borkar, Dipali B., and Vishal L. Bagde. "Role of Glutathion-S-Transferase in Imparting Resistance in Plutella Xylostella (L.) Against Flubendiamide." Indian Journal of Applied Research 3, no. 9 (2011): 7–8. http://dx.doi.org/10.15373/2249555x/sept2013/3.

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5

Su, Fengxi, Xiaoqu Hu, Weijuan Jia, Chang Gong, Erwei Song та Peter Hamar. "Glutathion s transferase π indicates chemotherapy resistance in breast cancer". Journal of Surgical Research 113, № 1 (2003): 102–8. http://dx.doi.org/10.1016/s0022-4804(03)00200-2.

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6

Kopylchuk, Halyna, and Ivanna Nykolaichuk. "Basic components of glutathion system in rat erythrocytes under conditions of toxic damage on the background of an alimental protein lack." Biolohichni systemy 12, no. 1 (2020): 31–38. http://dx.doi.org/10.31861/biosystems2020.01.031.

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The article is devoted to the study of the main components of the glutathione system under conditions of toxic damage against the background of nutritional protein deficiency: the content of reduced and oxidized glutathione with the determination of the GSH/GSSG ratio, the activity of glutathione-dependent enzymes – glutathione peroxidase, glutathione transferase, glutathione reductase, and glucose-6-phosphate dehydrogenase. The concentration of reduced glutathione in the erythrocyte hemolysate was studied using Elman's reagent after deproteinization of the samples. Glutathione transferase act
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7

Park, Hyeyoung, and Youn-Kyoo Choung. "Degradation of Antibiotics (Tetracycline, Sulfathiazole, Ampicillin) Using Enzymes of Glutathion S-Transferase." Human and Ecological Risk Assessment: An International Journal 13, no. 5 (2007): 1147–55. http://dx.doi.org/10.1080/10807030701506223.

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8

Verbeeck, MAE, P. Marx, EFM Wouters, SjSc Wagenaar, and FBJM Thunnissen. "Increased gene expression of glutathion-S-transferase-pi in human lung carcinomas." Cancer Genetics and Cytogenetics 77, no. 2 (1994): 173. http://dx.doi.org/10.1016/0165-4608(94)90328-x.

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9

Zamora, Zullyt B., Aluet Borrego, Orlay Y. López та ін. "Effects of Ozone Oxidative Preconditioning on TNF-αRelease and Antioxidant-Prooxidant Intracellular Balance in Mice During Endotoxic Shock". Mediators of Inflammation 2005, № 1 (2005): 16–22. http://dx.doi.org/10.1155/mi.2005.16.

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Ozone oxidative preconditioning is a prophylactic approach, which favors the antioxidant-prooxidant balance for preservation of cell redox state by the increase of antioxidant endogenous systems in both in vivo and in vitro experimental models. Our aim is to analyze the effect of ozone oxidative preconditioning on serum TNF-αlevels and as a modulator of oxidative stress on hepatic tissue in entodoxic shock model (mice treated with lipopolysaccharide (LPS)). Ozone/oxygen gaseous mixture which was administered intraperitoneally (0.2,0.4, and1.2mg/kg) once daily for five days before LPS (0.1mg/kg
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10

LAWAL-ARE, Aderonke Omolara, Rasheed Olatunji MORUF, Sarah Oyeyinka OLUSEYE-ARE, and Tajudeen Opeyemi ISOLA. "Antioxidant Defense System Alternations in Four Crab Species as a Bio-Indicator of Environmental Contamination." Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Veterinary Medicine 76, no. 1 (2019): 73. http://dx.doi.org/10.15835/buasvmcn-vm:2019.0001.

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The ecological health status of aquatic environment is a determinant for the survival and growth of organisms within such niche. An investigative study was carried out on four crab species – Cardiosoma armatum, Goniopsis pelli, Callinectes amnicola, Portunus validusinhabiting contaminated sites in Lagos Lagoon- exploring their anti-oxidant defense mechanism in the light of heavy metal concentration in the crab tissues. Amongst the measured heavy metals, cadmium level proved to be significantly highest (P<0.05) with range concentration of 0.42±0.12mg/kg (G. pelli)- 0.79±0.06 mg/kg (C. armatu
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11

Afifi, Mohamed, Omar A. Almaghrabi, and Naif Mohammed Kadasa. "Ameliorative Effect of Zinc Oxide Nanoparticles on Antioxidants and Sperm Characteristics in Streptozotocin-Induced Diabetic Rat Testes." BioMed Research International 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/153573.

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The present study investigated the impact of zinc oxide nanoparticles (ZnONPs) on the oxidative status and sperm characteristics in diabetic rat testicular tissue. Forty male albino rats were used in this study; 10 of them served as a control and 30 rats were injected with a single dose (100 mg/kg) of streptozotocin intraperitoneally. They were subdivided into diabetic, diabetic + ZnONPs (10 mg/kg B.W.), and diabetic and cotreated with ZnONPs + insulin groups. The sperm count and motility were assessed. The activity and mRNA expression of superoxide dismutase (SOD), catalase (CAT), glutathione
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12

Yang, Mon-Yuan, Tung-Wei Hung, Chau-Jong Wang, and Tsui-Hwa Tseng. "Inhibitory Effect of Nelumbo nucifera Leaf Extract on 2-Acetylaminofluorene-induced Hepatocarcinogenesis Through Enhancing Antioxidative Potential and Alleviating Inflammation in Rats." Antioxidants 8, no. 9 (2019): 329. http://dx.doi.org/10.3390/antiox8090329.

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Leaf extract of Nelumbo nucifera (NLE) has been demonstrated to possess anti-atherosclerosis, improve alcohol-induced steatohepatitis, prevent high-fat diet-induced obesity, and inhibit the proliferation and metastasis of human breast cancer cells. This study determines the chemopreventive role of NLE against 2-acetylaminofluorene (AAF)-induced hepatocellular carcinoma (HCC) in rats. AAF was used to induce hepatocarcinogenesis in rats through genetic and nongenetic effects. After administration for 12 weeks, NLE (0.5–2%) supplementation orally inhibited AAF (0.03%)-induced hepatic fibrosis whi
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13

Nurkhasanah, Laela Hayu Nurani, and Zainur Rahman Hakim. "Effect of rosella (Hibiscus sabdariffa L) extract on glutathione-S-transferase activity in rats." Tropical Journal of Pharmaceutical Research 16, no. 10 (2017): 2411–16. http://dx.doi.org/10.4314/tjpr.v16i10.14.

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Purpose: To determine the effect of rosella (Hibiscus sabdariffa L) extract on glutathione-S-trasferase (GST) activity and its hepatoprotective effect.Methods: A total of 25 rats were divided randomly into 5 groups (5 rats per group). Group I served as the baseline, group II was the negative control group, while groups III, IV and V were treated with rosella extract at doses of 10, 50 and 100 mg /kg /day, respectively for 35 days. On day 36, the animals were given a single dose of dimethyl benz(a)anthracene (DMBA) orally. After one week, blood was taken from the sinus orbitalis for measurement
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14

Neefjes, Veronica M., Chris T. Evelo, Leo Baars, and Carlos E. Blanco. "Glutathion-S-transferase as marker of oxidative stress in sick and healthy premature infants. † 985." Pediatric Research 41 (April 1997): 167. http://dx.doi.org/10.1203/00006450-199704001-01004.

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15

Komiya, Yasuhiro, Hiromasa Tsukino, Hiroyuki Nakao, Yoshiki Kuroda, Hirohisa Imai, and Takahiko Katoh. "Human glutathion S-transferase A1 polymorphism and susceptibility to urothelial cancer in the Japanese population." Cancer Letters 221, no. 1 (2005): 55–59. http://dx.doi.org/10.1016/j.canlet.2004.10.042.

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16

Movafagh, A., F. Maleki, S. G. Mohammadzadeh, and S. Fadaei. "Association of glutathion S-transferase and chromosomal aberrations as a means to determine occupational exposure." International Congress Series 1276 (February 2005): 197–98. http://dx.doi.org/10.1016/j.ics.2004.12.011.

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17

Zaets, Iryna, Sergij Kramarev, and Natalia Kozyrovska. "Inoculation with a bacterial consortium alleviates the effect of cadmium overdose in soybean plants." Open Life Sciences 5, no. 4 (2010): 481–90. http://dx.doi.org/10.2478/s11535-010-0025-1.

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AbstractInoculating plants that have inefficient antioxidant systems with plant-associated bacteria allows them to overcome heavy metal intoxication. We monitored protein oxidation, the activity of plant defense system enzymes, and the phenolics content in soybean (Glycine max L.) during a prolonged exposure to cadmium (Cd). The assistance of the bacterial consortium reduced the bioavailability of Cd in a soil containing 10 times the metal’s Standard Maximum Value (SMV). This reduced the accumulation of Cd in the soybeans’ roots and seeds. At 100 SMV, bacterial inoculation resulted in increase
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18

CHINAMI, MASANOBU, and MASAHISA SHINGU. "Construction of an Expression Vector for Human Papillomavirus Type 16 E7-Glutathion S Transferase Fusion Protein." Kurume Medical Journal 39, no. 1 (1992): 9–12. http://dx.doi.org/10.2739/kurumemedj.39.9.

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19

Jahnke, V., R. Strange, Chr Matthias, and A. A. Fryer. "Erste Ergebnisse über Glutathion-S-Transferase GSTM1 und GSTT1 Genotypen und die genetische Prädisposition beim Larynxkarzinom*." Laryngo-Rhino-Otologie 74, no. 11 (1995): 691–94. http://dx.doi.org/10.1055/s-2007-997826.

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20

Matthias, C., V. Jahnke, A. Fryer, and R. C. Strange. "Einfluss von Glutathion S-Transferase und Cytochrom P450 Genpolymorphismen auf das Verhalten von Kopf-Hals-Karzinomen." Laryngo-Rhino-Otologie 81, no. 06 (2002): 406–12. http://dx.doi.org/10.1055/s-2002-32208.

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21

Vyushina, A. V., A. V. Pritvorova, O. G. Semenova, and N. E. Ordyan. "The effect of prenatal stress on antioxidant glutathion-assosiated enzymes activity in subcellular fractions of rat's liver." Biomeditsinskaya Khimiya 67, no. 4 (2021): 347–51. http://dx.doi.org/10.18097/pbmc20216704347.

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The activity of glutathione-associated antioxidant enzymes in subcellular fractions (cytosolic, mitochondrial, and cell nucleus fractions) was investigated in the liver of adult male Wistar rats born after prenatal stress was. Two groups of animals were studied in the experiment: (1) control group included — animals was born by intact mothers, and (2) prenatal stress group included animals whose mothers were subjected to immobilization stress in high-light conditions from the 15th to the 19th day of pregnancy. The activity of glutathione peroxidase (EC 1.11.1.9) in prenatally stressed animals
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22

Weimin, Yang, Zeng Xiaoyong, Chen Chunlian, Chen Zhong та Du Guanghui. "Correlative expression of glutathion S-Transferase-π and multidrug resistance associated protein in bladder transitional cell carcinoma". Journal of Tongji Medical University 20, № 4 (2000): 311–14. http://dx.doi.org/10.1007/bf02888188.

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23

Беляева, Elena Belyaeva, Ершова, and Oksana Ershova. "Polymorphism of gene glutathion-s-transferase Pi in teenagers from Buryat ethnic group living in the irkutsk region." Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук 1, no. 5 (2016): 165–69. http://dx.doi.org/10.12737/23418.

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Human glutathione-S-transferases play an important role in phase II detoxification process. But poly-morphism in the GSTP1 gene has not been studied in certain populations.Aim: to determine the distribution of allele and genotype frequencies of GSTP1 gene in teenagers from Buryat ethnic group.Materials and methods. Blood samples were obtained from 55 teenagers from Buryat ethnic group. There were 28 males and 27 females with an age of 14.05±0.99 years over the range of 13 to 16. DNA was isolated from blood samples. The polymerase chain reaction was used to amplify A313G and C341T markers of th
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24

Tsikas, Dimitrios, Kay Kohlhaw, and Gorig Brunner. "Funktionen und Anwendung von Glutathion S-Transferase und Epoxid-Hydratase in einem enzymatischen Hohlfaser-Reaktor zur extrakorporalen Entgiftung." Chemie Ingenieur Technik 63, no. 11 (1991): 1150–51. http://dx.doi.org/10.1002/cite.330631126.

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25

Cakir, Tayfun, and Seyho Yucetas. "Comparison of glutathion-s-transferase A-4 expression values between lumbar spinal canal stenosis and lumbar discal hernia patients." Annals of Medical Research 26, no. 12 (2019): 2887. http://dx.doi.org/10.5455/annalsmedres.2019.09.534.

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26

Németh, Zs K., M. Abonyi, T. Tóth, Z. Bori, and P. Nagy. "The efficacy of alpha-glutathion-S-transferase determination asamarker of hepatic injury in asymptomatic HCV carriers,alcoholicsand drug abusers." Journal of Hepatology 32 (2000): 189. http://dx.doi.org/10.1016/s0168-8278(00)81050-8.

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27

Akgul, S. U., F. S. Oguz, Y. Çalişkan, et al. "The Effect of Glutathion S-Transferase Polymoprhisms and Anti-GSST1 Antibodies on Allograft Functions in Recipients of Renal Transplant." Transplantation Proceedings 44, no. 6 (2012): 1679–84. http://dx.doi.org/10.1016/j.transproceed.2012.04.004.

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28

Danielson, U. H., and B. Mannervik. "Paradoxical inhibition of rat glutathione transferase 4-4 by indomethacin explained by substrate-inhibitor-enzyme complexes in a random-order sequential mechanism." Biochemical Journal 250, no. 3 (1988): 705–11. http://dx.doi.org/10.1042/bj2500705.

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Under standard assay conditions, with 1-chloro-2,4-dinitrobenzene (CDNB) as electrophilic substrate, rat glutathione transferase 4-4 is strongly inhibited (I50 = 1 microM) by indomethacin. No other glutathione transferase investigated is significantly inhibited by micromolar concentrations of indomethacin. Paradoxically, the strong inhibition of glutathione transferase 4-4 was dependent on high (millimolar) concentrations of CDNB; at low concentrations of this substrate or with other substrates the effect of indomethacin on the enzyme was similar to the moderate inhibition noted for other glut
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Stockman, P. K., G. J. Beckett та J. D. Hayes. "Identification of a basic hybrid glutathione S-transferase from human liver. Glutathione S-transferase δ is composed of two distinct subunits (B1 and B2)". Biochemical Journal 227, № 2 (1985): 457–65. http://dx.doi.org/10.1042/bj2270457.

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The purification of a hybrid glutathione S-transferase (B1 B2) from human liver is described. This enzyme has an isoelectric point of 8.75 and the B1 and B2 subunits are distinguishable immunologically and are ionically distinct. Hybridization experiments demonstrated that B1 B1 and B2 B2 could be resolved by CM-cellulose chromatography and have pI values of 8.9 and 8.4 respectively. Transferase B1 B2, and the two homodimers from which it is formed, are electrophoretically and immunochemically distinct from the neutral enzyme (transferase mu) and two acidic enzymes (transferases rho and lambda
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Alin, P., H. Jensson, E. Cederlund, H. Jörnvall, and B. Mannervik. "Cytosolic glutathione transferases from rat liver. Primary structure of class alpha glutathione transferase 8-8 and characterization of low-abundance class Mu glutathione transferases." Biochemical Journal 261, no. 2 (1989): 531–39. http://dx.doi.org/10.1042/bj2610531.

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Six GSH transferases with neutral/acidic isoelectric points were purified from the cytosol fraction of rat liver. Four transferases are class Mu enzymes related to the previously characterized GSH transferases 3-3, 4-4 and 6-6, as judged by structural and enzymic properties. Two additional GSH transferases are distinguished by high specific activities with 4-hydroxyalk-2-enals, toxic products of lipid peroxidation. The most abundant of these two enzymes, GSH transferase 8-8, a class Alpha enzyme, has earlier been identified in rat lung and kidney. The amino acid sequence of subunit 8 was deter
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Özkan-Yılmaz, Ferbal, Arzu Özlüer-Hunt, Mehmet Berköz, and Metin Yıldırım. "Investigation of Glutathion S-Transferase, Adenosine deaminase, Paraoxonase Activities in Liver of Oncorhynchus mykiss Fed with Nucleotide-Yeast Supplemented Diet." Natural and Engineering Sciences 3, no. 3 (2018): 300–310. http://dx.doi.org/10.28978/nesciences.468960.

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32

Grubisa, Ivana, Petar Otasevic, Nebojsa Despotovic, Velimir Dedic, Jelena Milasin, and Nada Vucinic. "Genetic polymorphism of glutathion S-transferase P1 (GSTP1) Ile105Val and susceptibility to atherogenesis in patients with type 2 diabetes mellitus." Genetika 45, no. 1 (2013): 227–36. http://dx.doi.org/10.2298/gensr1301227g.

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One of the characteristics of type 2 diabetes mellitus (T2DM) is the state of persistent oxidative stress (OS) that has been implicated in the pathogenesis of diseases such is atherosclerosis mainly through chronic hyperglycemia that stimulates production of reactive oxygen species (ROS) and increases OS. Glutathione S-transferase P1 (GSTP1) is a member of the cytosolic GST superfamily. It plays an important role in neutralizing OS as an enzyme. Also, it participates in regulation of stress signaling and protects cells against apoptosis via its noncatalytic ligand-binding activity. GSTP1 Ile10
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33

Danielson, U. H., H. Esterbauer, and B. Mannervik. "Structure-activity relationships of 4-hydroxyalkenals in the conjugation catalysed by mammalian glutathione transferases." Biochemical Journal 247, no. 3 (1987): 707–13. http://dx.doi.org/10.1042/bj2470707.

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The substrate specificities of 15 cytosolic glutathione transferases from rat, mouse and man have been explored by use of a homologous series of 4-hydroxyalkenals, extending from 4-hydroxypentenal to 4-hydroxypentadecenal. Rat glutathione transferase 8-8 is exceptionally active with the whole range of 4-hydroxyalkenals, from C5 to C15. Rat transferase 1-1, although more than 10-fold less efficient than transferase 8-8, is the second most active transferase with the longest chain length substrates. Other enzyme forms showing high activities with these substrates are rat transferase 4-4 and huma
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34

Peters, W. H. M., H. M. J. Roelofs, F. M. Nagengast, and J. H. M. van Tongeren. "Human intestinal glutathione S-transferases." Biochemical Journal 257, no. 2 (1989): 471–76. http://dx.doi.org/10.1042/bj2570471.

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Cytosolic glutathione S-transferases were purified from the epithelial cells of human small and large intestine. These preparations were characterized with regard to specific activities, subunit and isoenzyme composition. Isoenzyme composition and specific activity showed little variation from proximal to distal small intestine. Specific activities of hepatic and intestinal enzymes from the same patient were comparable. Hepatic enzymes were mainly composed of 25 kDa subunits. Transferases from small intestine contained 24 and 25 kDa subunits, in variable amounts. Colon enzymes were composed of
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Hasni, Dita, Kamal B. Siregar, and Hadyanto Lim. "The influence of glutathion S-transferase P-1 polymorphism A313G rs1695 on the susceptibility to cyclophosphamide hematologic toxicity in Indonesian patients." Medical Journal of Indonesia 25, no. 2 (2016): 118–26. http://dx.doi.org/10.13181/mji.v25i2.1308.

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Background: Chemotherapy often causes side effects such as hematologic toxicity. The degree of toxicity is often associated with genetic polymorphism. This study aims to determine the influence of GSTP1 A313G polymorphism, an enzyme responsible for detoxifying cyclophosphamid, on incidence and severity of cyclophosphamid hematologic toxicity.Methods: 91 Indonesian females diagnosed with breast cancer at Haji Adam Malik Central General Hospital, Medan, receiving cyclophosphamide, doxorubicin/epirubicin and 5-FU were included in this retrospective cohort study. DNA was extracted from peripheral
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Schön, M. R., N. Akkoc, W. Heil та ін. "Die Bestimmung der α-Glutathion-S-Transferase-Konzentration zur Beurteilung hepatozellulärer Ischämieschäden im Vergleich zu GOT, GPT und LDH im Lebertransplantationsmodell." LaboratoriumsMedizin 23, № 4 (1999): 218–27. http://dx.doi.org/10.1515/labm.1999.23.4.218.

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Ilyinskikh, N. N., E. N. Ilyinskikh, A. M. Subbotin, and V. N. Nekrasov. "Teratozoospermia and karyopathological abnormalities of blood cells in human granulocytic anaplasmosis depending on polymorphism of GSTM1 gene of glutathion-S-transferase." Problemy reproduktsii 24, no. 5 (2018): 101. http://dx.doi.org/10.17116/repro201824051101.

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Kurz, M. A., T. D. Boyer, R. Whalen, T. E. Peterson, and D. G. Harrison. "Nitroglycerin metabolism in vascular tissue: role of glutathione S-transferases and relationship between NO. and NO2– formation." Biochemical Journal 292, no. 2 (1993): 545–50. http://dx.doi.org/10.1042/bj2920545.

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Nitroglycerin is a commonly employed pharmacological agent which produces vasodilatation by release of nitric oxide (NO.). The mechanism by which nitroglycerin releases NO. remains undefined. Recently, glutathione S-transferases have been implicated as important contributors to this process. They are known to release NO2- from nitroglycerin, but have not been shown to release NO.. The present studies were designed to examine the role of endogenous glutathione S-transferases in this metabolic process. Homogenates of dog carotid artery were incubated anaerobically with nitroglycerin, and NO. and
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Meyer, D. J., E. Lalor, B. Coles, et al. "Single-step purification and h.p.l.c. analysis of glutathione transferase 8–8 in rat tissues." Biochemical Journal 260, no. 3 (1989): 785–88. http://dx.doi.org/10.1042/bj2600785.

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GSSG selectively elutes two GSH transferases from a mixture of rat GSH transferases bound to a GSH-agarose affinity matrix. One is a form of GSH transferase 1-1 and the other is shown to be GSH transferase 8-8. By using tissues that lack this form of GSH transferase 1-1 (e.g. lung), GSH transferase 8-8 may thus be purified from cytosol in a single step. Quantitative analysis of the tissue distribution of GSH transferase 8-8 was obtained by h.p.l.c.
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Syafitri, Syafitri. "PENGARUH PEMBERIAN Curcuma xanthoriza Roxb TERHADAP PERBAIKAN KERUSAKAN SEL HEPAR." Jurnal Ilmu Kedokteran dan Kesehatan 6, no. 3 (2019): 236–41. http://dx.doi.org/10.33024/jikk.v6i3.2192.

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Hepatitis kronis merupakan salah satu masalah besar yang dihadapi dunia termasuk di Indonesia. Hepatitis kronis dapat berkembang menjadi progresif yang menjadi awal terjadinya sirosis hati dan akhirnya kanker hati pada 20-30 % kasus. Hepatitis secara patofisiologi akan menyebabkan kerusakan sel pada hati. Hepatoprotektor adalah suatu senyawa obat yang dapat memberikan perlindungan pada hati dari kerusakan yang ditimbulkan oleh racun, obat, dan lain-lain. Temulawak diteliti dapat berperan sebagai hepatoprotektor. Temulawak adalah salah satu tanaman herbal yang dapat dijadikan alternatif pengoba
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Schecter, Robyn L., Moulay A. Alaoui-Jamali, and Gerald Batist. "Glutathione S-transferase in chemotherapy resistance and in carcinogenesis." Biochemistry and Cell Biology 70, no. 5 (1992): 349–53. http://dx.doi.org/10.1139/o92-054.

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Cytosolic glutathione S-transferases are composed of two monomeric subunits. These monomers are the products of different gene families designated alpha, mu, and pi. Dimerization yields either homodimeric or heterodimeric holoenzymes within the same family. The members of this complex group of proteins have been linked to the detoxification of environmental chemicals and carcinogens, and have been shown to be overexpressed in normal and tumor cells following exposure to cytotoxic drugs. They also are overexpressed in carcinogen-induced rat liver preneoplastic nodules in rat liver. In all of th
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42

Tan, K. H., D. J. Meyer, N. Gillies, and B. Ketterer. "Detoxification of DNA hydroperoxide by glutathione transferases and the purification and characterization of glutathione transferases of the rat liver nucleus." Biochemical Journal 254, no. 3 (1988): 841–45. http://dx.doi.org/10.1042/bj2540841.

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DNA peroxidized by exposure to ionizing radiation in the presence of oxygen is a substrate for the Se-independent GSH peroxidase activity of several GSH transferases, GSH transferases 5-5, 3-3 and 4-4 being the most active in the rat liver soluble supernatant fraction (500, 35 and 20 nmol/min per mg of protein respectively) and GSH transferases mu and pi the most active, so far found, in the human liver soluble supernatant fraction (80 and 10 nmol/min per mg respectively). Although the GSH transferase content of the rat nucleus was found to be much lower than that of the soluble supernatant, n
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43

Bier, Henning, and Uwe Gamer. "ln-vitro-Untersuchungen an zehn Kopf-Hals-Karzinomlinien zur Abhängigkeit der Chemosensitivität vom Glutathiongehalt und von der Aktivität der Glutathion-S-Transferase." Oto-Rhino-Laryngologia Nova 4, no. 5-6 (1994): 273–77. http://dx.doi.org/10.1159/000313138.

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44

Chianale, Jose, Ana M. Wielandt та Valeska Vollrath. "Co-induction of multispecific organic anion transporter, Г-glutamylcysteine synthetase and glutathion-S-transferase genes by phenolic antioxidants in the mouse liver". Gastroenterology 118, № 4 (2000): A999. http://dx.doi.org/10.1016/s0016-5085(00)86148-x.

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45

Tahir, M. K., N. Ozer, and B. Mannervik. "Isoenzymes of glutathione transferase in rat small intestine." Biochemical Journal 253, no. 3 (1988): 759–64. http://dx.doi.org/10.1042/bj2530759.

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The major glutathione transferases in the rat small-intestine cytosol were isolated and characterized. The enzymes active with 1-chloro-2,4-dinitrobenzene as second substrate were almost quantitatively recovered after affinity chromatography on immobilized S-hexylglutathione. The different basic forms of glutathione transferase, which account for 90% of the activity, were resolved by chromatofocusing. Fractions containing enzymes with lower isoelectric points were not further resolved. The isolated fractions were characterized by their elution position in chromatofocusing, apparent subunit Mr,
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46

Paret, Aurelie, Delphine Rolland, Vincent Ribrag, Bertrand Coiffier, and Catherine Thieblemont. "Inhibition of GSTpi Activity Increases the Sensitivity of MCL Cell Lines to Cisplatin, Cytarabin and Bortezomib, but Not Doxorubicin." Blood 106, no. 11 (2005): 2806. http://dx.doi.org/10.1182/blood.v106.11.2806.2806.

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Abstract Preliminary data suggest drug resistance plays a major role in mantle cell lymphoma (MCL) and is linked to the aberrant expression of molecules such as Glutathion S-Transferase pi (GST pi) that catalyzes the nuclear conjugation of a broad variety of reactive electrophiles to the glutathion. We investigated in vitro the effect of the inhibition of GSTpi activity on the chemosensitivity of MCL cell lines by inhibiting the nuclear transport of GSTpi with Agaricus bisporus leptine (ABL). Methods. Four MCL cell lines (Granta, NCEB, REC and UPN1) were analyzed for GSTP1 transcript expressio
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47

Del Boccio, G., C. Di Ilio, P. Alin, H. Jörnvall, and B. Mannervik. "Identification of a novel glutathione transferase in human skin homologous with class alpha glutathione transferase 2-2 in the rat." Biochemical Journal 244, no. 1 (1987): 21–25. http://dx.doi.org/10.1042/bj2440021.

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Six forms of glutathione transferase with pI values of 4.6, 5.9, 6.8, 7.1, 8.5 and 9.9 have been isolated from the cytosol fraction of normal skin from three human subjects. The three most abundant enzymes were an acidic Class Pi transferase (pI 4.6; apparent subunit Mr 23,000), a basic Class Alpha transferase (pI 8.5; apparent subunit Mr 24,000) and an even more basic glutathione transferase of Class Alpha (pI 9.9; apparent subunit Mr 26,500). The last enzyme, which was previously unknown, accounts for 10-20% of the glutathione transferase in human skin. The novel transferase showed greater s
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48

Brophy, P. M., C. Southan, and J. Barrett. "Glutathione transferases in the tapeworm Moniezia expansa." Biochemical Journal 262, no. 3 (1989): 939–46. http://dx.doi.org/10.1042/bj2620939.

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Four forms of GSH transferase were resolved from Moniezia expansa cytosol by GSH-Sepharose affinity chromatography and chromatofocusing in the range pH 6-4, and the presence of isoenzymes was further suggested by analytical isoelectric focusing. The four GSH transferase forms in the cestode showed no clear biochemical relationship to any one mammalian GSH transferase family. The N-terminal of the major GSH transferase form showed sequence homology with the Mu and Alpha family GSH transferases. The major GSH transferase appeared to bind a number of commercially available anthelmintics but did n
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49

Çelık, Veysel Kenan, Zeynep Deniz Şahın, İsmail Sari, and Sevtap Bakir. "Comparison of Oxidant/Antioxidant, Detoxification Systems in Various Tissue Homogenates and Mitochondria of Rats with Diabetes Induced by Streptozocin." Experimental Diabetes Research 2012 (2012): 1–5. http://dx.doi.org/10.1155/2012/386831.

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Objective. Oxidative stress is considered to be the main factor in the development of diabetic complications and tissue injury. our objective was to investigate and compare the oxidant/antioxidant conditions and detoxification mechanisms of the liver, lung, kidney, cardiac tissues, and mitochondria of rats with diabetes induced by streptozocin (STZ).Methods. Rats with diabetes induced by streptozocin were anesthetized by administering 90 mg/kg ketamine hydrochloride and 3 mg/kg xylazine hydrochloride. Thoracic cavities were incised open; liver, lung, kidney, and cardiac tissues were removed an
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Gervas, Polina, Natalia Smetannikova, Maria Vasilieva, et al. "P2-008: Influence of common glutathion-S-transferase and DNA repair variant alleles on p53 function: relation to lung cancer risk and progression." Journal of Thoracic Oncology 2, no. 8 (2007): S484—S485. http://dx.doi.org/10.1097/01.jto.0000283450.55572.61.

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