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Dissertations / Theses on the topic 'Glutation transferasa'

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Published: 4 June 2021

Last updated: 6 February 2022

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1

Zavala, Figueroa Patricio. "Glutatión transferasa M2-2 previene los efectos tóxicos de aminocromo en una línea celular de astrocitos humanos (U373MG)." Tesis, Universidad de Chile, 2008. http://repositorio.uchile.cl/handle/2250/133756.

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Memoria para optar al Titulo Profesional de Médico Veterinario<br>El objetivo de este trabajo fue demostrar que la glutatión transferasa M2-2 humana (GST M2-2), protege a los astrocitos de los efectos tóxicos del aminocromo, ya que en estudios in vitro utilizando la enzima recombinante, se demostró que esta enzima conjuga aminocromo con glutation reducido (GSH), formando un metabolito resistente a agentes oxidativos biológicos, bloqueando de esta forma los efectos neurotoxicos generados por aminocromo. GST M2-2 está presente en la sustancia nigra y en astrocitos. Para demostrar la f

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2

Lafuente, Amàlia 1952. "Estudi dels tioèters urinaris. Noves aplicacions." Doctoral thesis, Universitat de Barcelona, 1986. http://hdl.handle.net/10803/698.

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No sabem quin nom serà emprat en la posteritat per a caracteritzar la nostra era però amb tota seguretat se la podria nomenar l'Era química, tal és el nombre de molècules sintetitzades per l'home que impregnen l'ambient que ens envolta en la nostra vida diària. Per això el nostre concepte de civilització moderna és inconcebible sense un entorn químic superimpost a l'entorn natural. Si la vida humana és millor gràcies a les nostres creacions químiques, o bé serà destruïda per elles, avui més que mai és una qüestió sense resposta (E. Pellegrino, 1976). Amb aquestes declaracions de Pellegrino, es

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3

Corrigall, Anne Vint. "Human glutathione S-transferases : characterization, tissue distribution and kinetic studies." Doctoral thesis, University of Cape Town, 1988. http://hdl.handle.net/11427/27205.

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In this study the purification of human basic and near-neutral liver, and human basic and acidic lung glutathione S-transferases (GSH S-T) was undertaken. Purification of the basic and near-neutral GSH S-T was achieved using a combination of affinity chromatography, chromatofocusing and immunoaffinity chromatography. Affinity and ion exchange chromatography were employed in the purification of the basic and acidic lung forms. The purified proteins had similar physicochemical characteristics to the GSH S-T purified by others. The binding of 1-chloro-2,4-dinitrobenzene (CDNB) to the 3 classes of

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4

Goold, Richard David. "The glutathione S-transferases : kinetics, binding and inhibition." Doctoral thesis, University of Cape Town, 1989. http://hdl.handle.net/11427/27175.

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The glutathione S-transferases are a group of enzymes which catalyse the conjugation of reduced glutathione with a variety of electrophilic molecules, and they are therefore thought to play a major role in drug biotransformation and the detoxification of xenobiotics. The cytosolic GSH S-transferase isoenzymes of rat, man and mouse have been assigned to three groups, Alpha, Mu and Pi, based on N-terrninal amino acid sequences, substrate specificities, immunological cross-reactivity and sensitivities to inhibitors. The kinetic mechanism of the GSH S-transferases is controversial, due to the obse

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5

Petit, Elise. "Etude des Glutathion Transférases : caractérisation de la classe Kappa et rôle de ces enzymes dans l'hépatotoxicité des Thiopurines." Rennes 1, 2007. http://www.theses.fr/2007REN1B072.

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Les Glutathion Tranférases (GST) constituent un système multienzymatique de détoxication. Elles sont impliquées dans la prévention , le développement des tumeurs et dans la réponse aux anticancéreux. Pendant ma thèse , je me suis intéressée à la GST de classe Kappa. Sa caractérisation nous a permis de mettre en évidence sa présence dans les mitochondries et les peroxysomes. Cette localisation particulière suggère que le GST Kappa pourrait avoir un rôle lié aux fonctions cellulaires de ces deux organites. Les GST étant en outre impliquées dans des phénomènes de résistance à des anticancéreux, j

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6

Guelfi, Andréa. "Bioinformática estrutural aplicada à evolução das glutationas transferases." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-04052006-161903/.

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As glutationas transferases compõem uma superfamíla de proteínas que atuam na fase II do sistema de desintoxicação das células. Participam principalmente através do processo de conjugação da glutationa com moléculas hidrofóbicas e eletrofílicas, como por exemplo os herbicidas. No entanto, outras funções foram descritas como a tolerância ao estresse oxidativo, inseticidas, antibióticos microbianos, transporte de produtos secundários tóxicos, sinalização da célula durante as respostas ao estresse e fenômenos de resistência envolvendo agentes de quimioterapia contra o câncer. Nesta tese procurou

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7

Cardoso, Filho Cassio 1974. "Influencia dos polimorfismos dosalelos Mu 1 (GSTM1) e Theta 1 (GSTT1) do sistema da glutatina S-transferase na susceptibilidade ao cander de mama esporadico." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311115.

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Orientador: Maria Salete Costa Gurgel<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-09T01:46:42Z (GMT). No. of bitstreams: 1 CardosoFilho_Cassio_M.pdf: 1571004 bytes, checksum: 252da74a9dd5114a82f05ed36b7face1 (MD5) Previous issue date: 2007<br>Resumo: Introdução: As deleções dos genes GSTM1 e GSTT1 têm sido associadas ao aumento do risco de várias neoplasias, porém não há consenso sobre suas influências no câncer de mama. Objetivo: Avaliar a ocorrência das deleções homozigóticas dos GSTM1 e GSTT1 em mulher

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8

Loterio, Guaracini Aparecida. "Os Genes Codificadores de Glutationa S-transferases na Abelha Apis mellifera: Expressão, Regulação e Função Durante e Após a Metamorfose." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-19012012-155709/.

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Em insetos, as enzimas glutationa S-transferases (GSTs) são conhecidas pela capacidade de degradar inseticidas, pesticidas e outros compostos químicos, naturais ou não naturais, estranhos ao organismo, podendo também promover o transporte intracelular de hormônios, metabólitos, e atuar na proteção celular contra o estresse oxidativo. Além disto, a função de uma GST tem sido associada ao processo de sequestro, pelo corpo gorduroso, de um tipo de proteína (hexamerinas) estocada na hemolinfa larval para ser utilizada como fonte de aminoácidos durante a metamorfose. Os objetivos deste trabalho con

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9

Giralt, Batista Montserrat. "Estudi del sistema glutatio/glutatio s-transferasa en glandula sebacia humana." Universitat Rovira i Virgili, 1992. http://www.tesisenxarxa.net.

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10

Franco, Ricardo Laier. "Expressão tumoral da glutationa S-transferase Pi e sobrevida global e livre de doença em mulheres com carcinoma de mama." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311112.

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Orientador: Maria Salete Costa Gurgel<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-11T12:25:32Z (GMT). No. of bitstreams: 1 Franco_RicardoLaier_M.pdf: 1204778 bytes, checksum: 4a5d4c7eb9039f14fc0392b4e8d9abb5 (MD5) Previous issue date: 2008<br>Resumo: Introdução: A glutationa S-transferase (GST) é um sistema enzimático localizado no citosol celular e é responsável pela eliminação de toxinas. Estudos realizados in vitro mostraram que a presença deste sistema nas células do carcinoma de mama pode promover a

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11

Nieslanik, Brenda Sue. "A structure-function analysis of the C-terminus in glutathione S-transferase A1-1 /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/8163.

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12

Lyon, Robert Patrick. "Enzymology at the dimer interface of cytosolic glutathione S-transferases /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/8165.

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13

Bastos, Frederico Freire. "Melatonina, isoenzimas de glutationa S-transferases e estresse oxidante em pacu Piaractus mesopotamicus (Holmberg, 1887)." Universidade do Estado do Rio de Janeiro, 2010. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2991.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>O oxigênio é fundamental para os vertebrados. No entanto, variações dos níveis de oxigênio na água podem provocar estresse oxidante em peixes porque privação de oxigênio seguida de reoxigenação forma espécies reativas de oxigênio (ERO) em células. Níveis intracelulares de ERO aumentados favorecem que moléculas de proteínas, fosfolipídios e ácidos nucleicos sofram alterações, vindo a prejudicar muitas funções celulares. No Pantanal, habitat do pacu, o nível de oxigênio varia circadianamente na água das lagoas rasas que acabam isol

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14

Di, Ilio C. "Studies on bacterial glutathione transferase." Thesis, Cranfield University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333472.

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15

Rodrigues, Nathalia de Campos. "Estudos estruturais do domínio GTPase isolado da septina humana SEPT4 e estrutura cristalográfica da Glutationa -S- Transferase de Xylella fastidiosa." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-05122008-152844/.

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As septinas constituem uma conservada família de proteínas de ligação a nucleotídeos de guanina e formação de heterofilamentos. Em mamíferos, tais proteínas estão envolvidas em uma variedade de processos celulares tais como citocinese, exocitose e tráfego de vesículas. A SEPT4 tem sido identificada em depósitos filamentosos e inclusões citoplasmáticas em Alzheimer e doença de Parkinson, respectivamente. A SEPT4 é a única proteína em associação com proteínas aberrantes em depósitos em ambos os tipos de doenças Assim, estudos adicionais de propriedades bioquímicas estruturais e funções fisiológi

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16

Dalton, K. G. "Glutathione transferase isoenzymes in rat hepatocarcinogenesis." Thesis, University of Bradford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379829.

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17

Troughton, P. R. "Isoenzymes of rat glutathione S-transferase." Thesis, University of Bradford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371503.

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18

Tamaki, Hisanori. "Studies on Yeast Glutathione S-Transferase." Kyoto University, 1991. http://hdl.handle.net/2433/168776.

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本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>農学博士<br>甲第4688号<br>農博第649号<br>新制||農||585(附属図書館)<br>学位論文||H3||N2261(農学部図書室)<br>UT51-91-C106<br>京都大学大学院農学研究科食品工学専攻<br>(主査)教授栃倉辰六郎, 教授木村光, 教授佐々木隆造<br>学位規則第5条第1項該当

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19

Honma, Helen Naemi 1971. "Influencia dos polimorfismos nos genes CYP1A1*2A, GSTM1, GSTT1 e GSTP1*B na susceptibilidade ao cancer de pulmão." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310260.

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Orientadores: Lair Zambon, Carmen Silvia Passos Lima<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-09T12:57:06Z (GMT). No. of bitstreams: 1 Honma_HelenNaemi_M.pdf: 6073042 bytes, checksum: 8de4d548610b680b2101397d10fc9e52 (MD5) Previous issue date: 2007<br>Resumo: A citocromo P- 450 1A1 (CYP1A1) é uma importante enzima do metabolismo carcinogênico, em virtude da regulação polimórfica, a CYP1A1 é um marcador genético promissor para susceptibilidade de certas malignidades, particularmente o câncer de pulmão (

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20

Búfalo, Natássia Elena 1981. "Estudo da relação entre o perfil genetico de diferentes sistemas de defesa contra xenobioticos nas doenças neoplasica e auto-imune da tiroide." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310276.

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Orientador: Laura Sterian Ward<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-10T20:51:35Z (GMT). No. of bitstreams: 1 Bufalo_NatassiaElena_M.pdf: 3282180 bytes, checksum: 0aa23171bc5ca7c18ed18eb22b3a23d2 (MD5) Previous issue date: 2007<br>Resumo: Tanto a doença de Graves como o câncer da tiróide são doenças de etiologia multifatorial e envolvem uma interação entre meio ambiente e fatores genéticos de predisposição. O ábito e fumar é um fator de risco reconhecido para o desenvolvimento da doença de Graves,

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21

Giralt, Batista Montserrat. "Estudi del sistema glutatió/glutatió s-transferasa en glandula sebacia humana." Doctoral thesis, Universitat Rovira i Virgili, 1992. http://hdl.handle.net/10803/8851.

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22

Lu, Weiya Douglas. "Photophysical consequences from interactions of glutathione S-transferases with the photodynamic sensitizer hypericin /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/8638.

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23

Saudrais, Élodie. "Mécanismes de neuroprotection liés au glutathion dans la barrière sang - liquide céphalorachidien choroïdienne au cours du développement périnatal." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1026/document.

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Plus de 50 % des handicaps neurodéveloppementaux sont dus à une exposition périnatale à des stress toxiques ou oxydants. Comprendre comment le cerveau est protégé au cours du développement périnatal et pourquoi ses mécanismes de défense sont dépassés lorsque l’enfant est soumis à un stress important est donc crucial. La barrière sang – liquide céphalorachidien (LCR), localisée au niveau des plexus choroïdes, présente une capacité de détoxification élevée et pourrait donc avoir un rôle prépondérant dans la protection du cerveau au stade périnatal. Nous avons étudié la capacité de plusieurs enzy

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24

Rinck, Júnior José Augusto 1974. "Influência dos polimorfismos dos genes Mu 1 (GSTM1), Theta 1 (GSTT1), XPD Asp312Asn e XPD Lys751Gln na susceptibilidade ao melanoma cutâneo." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308608.

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Orientador: Carmen Silvia Passos Lima<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-26T16:24:35Z (GMT). No. of bitstreams: 1 RinckJunior_JoseAugusto_D.pdf: 4925898 bytes, checksum: cf6e78a6e4ad84c7bbe48d34d75fdae6 (MD5) Previous issue date: 2015<br>Resumo: As glutationa S-transferases (GSTs) são enzimas detoxificantes. Os genes GSTM1 e GSTT1 são polimórficos e quando deletados perdem a expressão enzimática. As proteínas codificadas pelos genes XPD são responsáveis pelo reparo de lesões do DNA causadas pela luz so

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25

Svensson, Richard. "The kinetic mechanism of microsomal glutathione transferase 1 (MGST1) /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-574-3/.

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26

Ibarra, Catherine A. "The functional role of Phe-10 and the anomalous Tyr-9 pKa in glutathione S-transferase A1-1 /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/8186.

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27

Ahmad, Laziana. "Characterisation of glutathione transferase from Arabidopsis thaliana." Thesis, University of York, 2017. http://etheses.whiterose.ac.uk/17477/.

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Glutathione transferases (GSTs) are soluble enzymes with activity towards a wide range of xenobiotic and endogenous compounds. The Arabidopsis genome encoded 54 GSTs, which have been classified into eight classes including Tau and Phi. Members of these Tau and Phi clades are strongly upregulated in response to abiotic stresses such as xenobiotics and biotic stresses including pathogen attack. The most characterised activity of GSTs is the transfer of glutathione to an electrophilic centre to form a polar glutathionylated conjugate. However, increasing number of research demonstrated a non-cata

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28

Evelo, Christoffel Theodorus Anthonius. "Toxicological stress indicators in human red blood cells changes in glutathione and glutathione S-transferase as biological markers for electrophilic and oxidative stress /." [Maastricht : Maastricht : Rijksuniversiteit Limburg] ; University Library, Maastricht University [Host], 1995. http://arno.unimaas.nl/show.cgi?fid=6632.

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29

Eklund, Birgitta I. "Role of Multiple Glutathione Transferases in Bioactivation of Thiopurine Prodrugs : Studies of Human Soluble Glutathione Transferases from Alpha, Kappa, Mu, Omega, Pi, Theta, and Zeta Classes." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7102.

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Mendes, Josiane Enevina. "Docking de herbicidas na glutationa transferase tau4-4 de soja (Glycine max)." Universidade Federal de São Carlos, 2011. https://repositorio.ufscar.br/handle/ufscar/6974.

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Made available in DSpace on 2016-08-17T18:39:37Z (GMT). No. of bitstreams: 1 3640.pdf: 5869617 bytes, checksum: 4643e7ab6ff128afd74bd3d51d8588f3 (MD5) Previous issue date: 2011-03-30<br>Financiadora de Estudos e Projetos<br>This study, based on molecular docking, describes the search for the most favorable conformations when complexes between herbicides, used in soybean cultivation, and an enzyme involved in the detoxification process are formed and based on these results some guidelines for the developing of new compounds are proposed. The glutathione transferase Tau, GmGSTU4-4, from soybea

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Frare, Ariane Bocaletto. "INVESTIGAÇÃO DOS POLIMORFISMOS GSTM1 E GSTT1 EM MULHERES COM ENDOMETRIOSE." Pontifícia Universidade Católica de Goiás, 2011. http://localhost:8080/tede/handle/tede/2337.

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Made available in DSpace on 2016-08-10T10:38:29Z (GMT). No. of bitstreams: 1 Ariane Bocaletto Frare.pdf: 1200781 bytes, checksum: 8bd7ce42ea14c46d6e84c7f5311b07ca (MD5) Previous issue date: 2011-06-16<br>Endometriosis is a benign gynecological pathology dependent on estrogen, which affects 10% of women of reproductive age, it is characterized by the presence of endometrial tissue outside the uterine cavity. Its etiology remains unknown, thus an increasing number of researches have been conducted in the search for associations between endometriosis and alterations or polymorphisms in candidat

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Silva, Constanza Thaise Xavier. "ANÁLISE DO POLIMORFISMO DA GLUTATIONA STRANSFERASE M1 E T1 EM PACIENTES PORTADORES DE GLAUCOMA PRIMÁRIO DE ÂNGULO ABERTO." Pontifícia Universidade Católica de Goiás, 2012. http://localhost:8080/tede/handle/tede/2349.

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Made available in DSpace on 2016-08-10T10:38:34Z (GMT). No. of bitstreams: 1 CONSTANZA THAISE XAVIER SILVA.pdf: 856711 bytes, checksum: aa9a8d8094cd18595af6092fc0d17683 (MD5) Previous issue date: 2012-03-12<br>Glaucoma refers to a group of eye diseases that gradually evolve being characterized by typical damage to the optic nerve with consequent changes in vision. The most common type is the primary open angle glaucoma (POAG) corresponding to approximately 60% of cases. The ocular epithelia expressed genes encoding the enzymes Glutathione STransferase (GST). The GST is present in various ocu

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Dixit, Vaishali S. "Inactivation of glutathione s transferase zeta by dichloroacetic acid." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0010021.

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Thesis (Ph. D.)--University of Florida, 2005.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 98 pages. Includes Vita. Includes bibliographical references.

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Dixon, David Peter. "Glutathione transferases in maize (Zea mays)." Thesis, Durham University, 1998. http://etheses.dur.ac.uk/4788/.

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The glutathione transferases (GSTs) of maize have been the most studied GSTs in plants, however much is still not known about these enzymes. In the course of the current study six GST subunits (Zm GSTs I, II and III, which have been reported previously, and Zm GSTs V, VI and VII, which have not been previously reported) have been identified in the dimers Zm GST I-I, I-II, I-III, V-V, V-VI and V-VII. Maize GSTs are known to be important in herbicide detoxification and the purified maize enzymes were each found to have differing activities toward a number of herbicides, and also a range of other

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35

Hayes, Peter C. "Glutathione S-transferases in the pancreas." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/19832.

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Glutathione S-transferase (GST) is an important xenobiotic metabolising enzyme which has been extensively studied in the liver. In the first part of this study immunohistochemistry was used to identify the presence and histological localisation of different GST isoenzymes in various gastrointestinal tract tissues in the human in health and disease. GSTP was found throughout the gastrointestinal and biliary tract whilst the position and quantity of other isoenzymes varied locally. Increased expression of GSTP was observed in cholangiocarcinoma and colonic adenocarcinoma, but not hepatocellular

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36

Holm, Peter. "Structural and functional studies of microsomal glutathione transferase 1 /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-264-0/.

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37

Turková, Lucie. "Porovnání sekvenčních variant genů pro biotransformační enzymy u různých typů karcinomů." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2017. http://www.nusl.cz/ntk/nusl-295694.

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Xenobiotic biotransformation process and its capacity is crucial for xenobiotic chemicals elimination that may cause damage toward cell structures. The effectiveness of the enzymes included in this process depends on the gene variants that encodes them. The aim of this work was to compare certain polymorphisms of selected genes between cases and control groups. Studied polymorphisms were null genotypes of the glutathione S-transferase gene M1 and T1 and the insertion of TA dinucleotide in the promotor region of UDP-glucuronosyl transferase 1A1. The number of cases group was six included patien

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38

AUDAN, ALAIN. "Status de l'acetyl- et de la glutathion-transferases chez les porteurs d'adenomes colo-rectaux : etude preliminaire." Nantes, 1994. http://www.theses.fr/1994NANT204M.

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39

Tea, Borany. "Rôle du système glutathion-glutathion-s-transférases dans la chimiothérapie anticancéreuse." Paris 5, 1997. http://www.theses.fr/1997PA05P079.

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Pincinato, Eder de Carvalho 1974. "Polimorfismos em genes do sistema da glutationa-S-transferase de detoxificação celular na farmacogenética da cisplatina associada à radioterapia em portadores de carcinoma de células escamosas de cabeça e pescoço." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308607.

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Orientador: Carmen Silvia Passos Lima<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-27T18:37:49Z (GMT). No. of bitstreams: 1 Pincinato_EderdeCarvalho_D.pdf: 3229024 bytes, checksum: a92cc669d0c70abe36aab0ff261da986 (MD5) Previous issue date: 2015<br>Resumo: A cisplatina (CDDP) associada à radioterapia (RT) é utilizada no tratamento de portadores de carcinoma de células escamosas de cabeça e pescoço (CCECP). A resposta ao tratamento bem como seus efeitos colaterais variam de indivíduo para indivíduo e tal fato pod

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Lima, Brena de Lourdes Aguiar. "Caracterização molecular das enzimas glutationa stransferase (genes gstt1, gstm1 e gstp1) em pacientes com malária por plasmodium vivax." Universidade Federal do Amazonas, 2013. http://tede.ufam.edu.br/handle/tede/2576.

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Made available in DSpace on 2015-04-11T13:54:30Z (GMT). No. of bitstreams: 1 Brena de Lourdes Aguiar Lima.pdf: 1248497 bytes, checksum: d14922a8c86943653012f0ea3e3818cf (MD5) Previous issue date: 2013-04-08<br>CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Plasmodium vivax threatens ~40% of the world s population, with a wide spectrum of asymptomatic to severe clinical manifestations. Glutathione S-transferase (GST) gene polymorphisms have been shown to influence their ability to reduce oxidative stress. Using molecular tools we identified and compared GSTM1, GSTT1

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Júnior, Evandro Antônio Bentes de Oliveira. "Alpha Glutationa S Transferase: marcador de lesão hepática em pacientes com hepatite pelo vírus C?" Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-19032007-101313/.

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INTRODUÇÃO E OBJETIVOS: A a-Glutathiona-S-transferase (aGST) vem sendo proposta como um marcador sensível e não-invasivo de lesão hepática em pacientes com Hepatite pelo vírus C. Avaliamos neste trabalho como a (aGST) se correlaciona com características bioquímicas e histológicas em pacientes com HCV. MATERIAL E MÉTODOS: Realizamos a determinação da concentração plasmática das aGST, alanina aminotransferase (ALT), aspartato aminotransferase (AST) e gama-glutamyltransferase (gGT) em 114 pacientes com HCV, dos quais 97 foram submetidos à biópsia hepática em até 6 meses da realização dos testes b

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Al-Suwaidan, I. A. "Heterocyclic compounds as novel substrates for glutathione transferase." Thesis, University of Bradford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378114.

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Bakker, Jila. "Glutathione s-transferase PI regulation in heptatocellular carcinoma." Available to US Hopkins community, 2002. http://wwwlib.umi.com/dissertations/dlnow/3068115.

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McLellan, Lesley I. "Cytosolic and microsomal isoenzymes of glutathione S-transferase." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/19129.

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Sun, Tie-Hua. "Microsomal glutathione transferase : studies on the kinetic mechanism, species variety, binding properties and substrate measurement /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3726-5/.

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McHugh, Thomas Erik. "Metabolism of aflatoxin epoxide by glutathione S-transferase : new insights into GST function /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/8446.

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Ralat, Luis A. "Insights into the multiple functions of glutathione S-transferase P1-1 characterization of its several ligand sites and examination of its interaction with 1-cysteine peroxiredoxin /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 263 p, 2008. http://proquest.umi.com/pqdweb?did=1679675771&sid=8&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Grundy, Nicholas Matthew. "Protein S-thiolation and oxidative stress in plants." Thesis, Durham University, 2002. http://etheses.dur.ac.uk/3950/.

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The tripeptides glutathione (GSH; γglutamyl-cysteinyl-glycine) and homoglutathione (hGSH; γglutamyl-cysteinyl-β-alanine) are abundant cytosolic tripeptides in legumes. The reactive cysteinyl sulphydryl group enables GSH or hGSH to act as the major cellular redox buffer through the formation of disulphides with other GSH/hGSH molecules. GSH can also form disulphides with cysteinyl groups within proteins, which is termed 5-thiolation, a reversible modification, protecting proteins from irreversible inactivation of thiol residues, as well as being important in regulating protein activity. Followi

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Thumser, Alfred Ernst Adolf. "The glutathione S-transferases : inhibition, activation, binding and kinetics." Thesis, University of Cape Town, 1990. http://hdl.handle.net/11427/28958.

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