Academic literature on the topic 'Gly-Pro'

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Journal articles on the topic "Gly-Pro"

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GUANTIERI, V., A. M. TAMBURRO, D. CABROL, H. BROCH, and D. VASILESCU. "Conformational studies on polypeptide models of collagen. Poly(Gly-Pro-Val), poly(Gly-Pro-Met), poly(Gly-Val-Pro) and poly(Gly-Met-Pro)." International Journal of Peptide and Protein Research 29, no. 2 (2009): 216–30. http://dx.doi.org/10.1111/j.1399-3011.1987.tb02248.x.

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Шевченко, Константин Валерьевич, Татьяна Владимировна Вьюнова, Людмила Александровна Андреева, Игорь Юлианович Нагаев, Валерий Павлович Шевченко та Николай Федорович Мясоедов. "Протеолиз Pro-Gly-Pro-Leu в гиппокампе, мозжечке и коре мозга крыс при интраназальном введении". Химико-фармацевтический журнал 49, № 2 (2015): 12–17. http://dx.doi.org/10.30906/0023-1134-2015-49-2-12-17.

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Показано, что при интраназальном введении тетрапептида Pro-Gly-Pro-Leu его концентрация, а также концентрация его метаболитов (Gly-Pro-Leu, Pro-Gly-Pro, Gly-Pro и Pro-Gly) в разных отделах мозга — гиппокампе, мозжечке и коре мозга крыс — зависит от времени. Максимальное содержание меченного тритием Pro-Gly-Pro-Leu и продуктов его деградации в мозге крыс наблюдается через 40 мин и составляет 0,07 % от количества исходно введенного. Максимальная концентрация Pro-Gly-Pro-Leu в мозжечке составила 2,37 пмоль/г, в гиппокампе — 1,93 пмоль/г, в коре мозга — 0,67 пмоль/г. Распределение в этих отделах м
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Younes, M. E., S. Abdel Rahman, and A. Hattaba. "Synthesis of elastin-like peptides using the liquid phase method." Collection of Czechoslovak Chemical Communications 52, no. 5 (1987): 1352–55. http://dx.doi.org/10.1135/cccc19871352.

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Elastin-like peptides were synthesized by the liquid-phase method using poly(ethylene glycol) monomethyl ether (PEGM) (m.w. 5 000) as solubilizing support which provides an alternative possibility for conformational studies and spectroscopic measurements in solution. The following sequences were synthesized: Boc-Ala-Pro-Gly-Val-APEGM, Boc-Ala-Pro-Gly-Val-Gly-Val-APEGM, Boc-Ala-Pro-Gly-Val-Ala-Pro-Gly-Val-Gly-Val-APEGM, Boc-Ala-Pro-Gly-Val-Gly-Val-Ala-Pro-Gly-Val-Gly-Val-APEGM.
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Okuyama, Kenji, Tatsuya Kawaguchi, Masaki Shimura, Keiichi Noguchi, Kazunori Mizuno, and Hans Peter Bächinger. "Crystal structure of the collagen model peptide (Pro-Pro-Gly)4-Hyp-Asp-Gly-(Pro-Pro-Gly)4at 1.0 Å resolution." Biopolymers 99, no. 7 (2013): 436–47. http://dx.doi.org/10.1002/bip.22198.

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Jiravanichanun, Nattha, Chizuru Hongo, Guanghan Wu, et al. "Unexpected Puckering of Hydroxyproline in the Guest Triplets, Hyp-Pro-Gly and Pro-alloHyp-Gly Sandwiched between Pro-Pro-Gly Sequence." ChemBioChem 6, no. 7 (2005): 1184–87. http://dx.doi.org/10.1002/cbic.200500055.

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Shevchenko, K. V., I. Yu Nagaev, L. A. Andreeva, V. P. Shevchenko, and N. F. Myasoedov. "Stability of prolin-containing peptides in biological media." Biomeditsinskaya Khimiya 65, no. 3 (2019): 180–201. http://dx.doi.org/10.18097/pbmc20196503180.

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New data on peptide drugs have been summarized; their high stability is due to both the introduction of Pro-Gly-Pro in various amino acid sequences and the modification of the glyproline fragment itself. Pro-Gly-Pro-Leu, ACTH(6-9)Pro-Gly-Pro, 5-oxo-Pro-Arg-Pro and 5-oxo-Pro-His-Pro-NH2 were used as proline-containing peptides. Tritiated peptides were obtained: Pro-Gly-Pro-Leu with specific radioactivity of 135 Ci/mmol, ACTH(6-9)Pro-Gly-Pro – 26 Ci/mmol, 5-oxo-Pro-Arg-Pro – 60 Ci/mmol and 5-oxo-Pro-His-Pro-NH2 – 75 Ci/mmol. The concentration of Pro-Gly-Pro-Leu, ACTH(6-9)Pro-Gly-Pro, 5-oxo-Pro-A
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ROTH, W., and E. HEIDEMANN. "TRIPLE HELIX COIL TRANSITION OF A BLOCKPOLYMER WITH THE SEQUENCE BOC-(GLY-PRO-PRO)5-(GLY-PRO-LEU)5-(GLY-PRO-PRO)5-NH2." International Journal of Peptide and Protein Research 17, no. 5 (2009): 527–30. http://dx.doi.org/10.1111/j.1399-3011.1981.tb02024.x.

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Shevchenko, V. P., L. A. Andreeva, I. Yu Nagaev, and N. F. Myasoedov. "Peptide derivatives of some physiologically active substances." Доклады Академии наук 487, no. 1 (2019): 41–44. http://dx.doi.org/10.31857/s0869-5652487141-44.

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The synthesis of Boc-Gly-Pro-Dox, Boc-Gly-Pro-DOPA, Boc-Gly-Pro-Srt and their deuterated analogs was carried out. It was shown that these condensations proceed with side reactions, which could be minimized by optimizing the conditions for the synthesis. The most universal approach to the synthesis of Boc-Gly-Pro-Dox, Boc-Gly-Pro-DOPA, Boc-Gly-Pro-Srt and their deuterated analogs is condensation of Boc-Gly-Pro or Boc-Gly-[2H]Pro with amino groups of dopamine, serotonin and doxorubicin. It was found that for the introduction of hydrogen isotopes in ΔPro, it is advisable to hydrogenate its aqueou
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Liao, Wenzhen, Longjian Gu, Yamei Zheng, et al. "Analysis of the quantitative structure–activity relationship of glutathione-derived peptides based on different free radical scavenging systems." MedChemComm 7, no. 11 (2016): 2083–93. http://dx.doi.org/10.1039/c6md00006a.

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In the present study, eleven glutathione-derived peptides, including Glu-Cys-His, Pro-Leu-Gly, Pro-Cys-Gly, Phe-Lys-Leu, Leu-His-Gly, Lys-Leu-Glu, Lys-Val-His, Tyr-Glu-Gly, Tyr-His-Leu, Gly-Glu-Leu and Gly-Pro-Glu, were designed.
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Шевченко, Константин Валерьевич, Игорь Юлианович Нагаев, Людмила Александровна Андреева, Валерий Павлович Шевченко та Николай Федорович Мясоедов. "Перспективы использования интраназального введения для доставки нейропептидов в головной мозг". Химико-фармацевтический журнал 53, № 2 (2019): 3–15. http://dx.doi.org/10.30906/0023-1134-2019-53-2-3-15.

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Преимуществами интраназального метода введения (ИМВ) лекарственных препаратов является неинвазивность, безболезненность, простота и удобство применения. Показаны основные подходы, связанные с решением задач по эффективной доставке в мозг пептидов через слизистую носа с учетом особенности анатомии и физиологии носовой полости. ИМВ позволяет обойти гематоэнцефалический барьер, но сталкивается с проблемой протеолиза пептидов под действием компонентов слизи обонятельного эпителия — с ферментативным барьером. В качестве реперных пептидов для экспериментов in vivo использовали Pro-Gly-Pro, Pro-Gly-P
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Dissertations / Theses on the topic "Gly-Pro"

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Barbosa, Breno Ferreira. "Ação antinociceptiva do Cyclo(Gly-Pro) sobre a dor orofacial em roedores." Universidade Federal de Sergipe, 2014. https://ri.ufs.br/handle/riufs/5888.

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Cyclo(Gly-Pro)(CGP) is a dipeptide that can be extracted from the fungus Rhizoctonia sp. or synthesized. The Rhizoctonia is a derived the kingdom Fungi, whose representatives inhabiting endophytic soil organisms of various vegetables genre. Among the plants possessing this fungus, deserves mastic-red (Schinus terebinthifolius Raddi) which is popularly used for different purposes, including inflammation. Thus, the aim of this study was to evaluate the possible antinocicetivo action on orofacial pain of Cyclo(Gly-Pro) in rodents. To this end, 90 male Swiss mice (25 to 35g) with 2 to 3 mont
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Collis, Antonia Bryony Kay. "Molecular dynamics simulations of aqueous glutamate and the gly-pro-glu (GPE) tripeptide." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5757.

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Biomolecular systems, in particular those involving proteins and their constituents, have been the focus of much research in the last century. The relationship between experiment, development of models and simulation has enabled vast improvements in our knowledge of subjects such as protein folding and the processes by which key biomolecules affect the human body. In particular, vital information can be obtained from understanding the building blocks of polypeptides and proteins involved in these processes. This work focuses on simulating two such building blocks; glutamate, the salt of the pr
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Craven, Cyril John. "The mechanism of maturation of insulin-like growth factor-1." Thesis, Queensland University of Technology, 1999. https://eprints.qut.edu.au/37030/7/37030_Digitised%20Thesis.pdf.

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This study, to elucidate the role of des(1-3)IGF-I in the maturation of IGF-I,used two strategies. The first was to detect the presence of enzymes in tissues, which would act on IGF-I to produce des(1-3)IGF-I, and the second was to detect the potential products of such enzymic activity, namely Gly-Pro-Glu(GPE), Gly-Pro(GP) and des(l- 3)IGF-I. No neutral tripeptidyl peptidase (TPP II), which would release the tripeptide GPE from IGF-I, was detected in brain, urine nor in red or white blood cells. The TPPlike activity which was detected, was attributed to a combined action of a dipeptidyl pep
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Galaud, Fabrice. "Synthèse et applications des sulfamidates cycliques." Thèse, 2005. http://hdl.handle.net/1866/16765.

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Books on the topic "Gly-Pro"

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Darmstadt, Technische Hochschule, ed. Synthese und Konformationsuntersuchungen von kovalent trimerverbrückten Kollagen-Modellpeptiden, die die Tripeptideinheiten Gly-Glu-Hyp, Gly-Phe-Hyp, Gly-Pro-Hyp und Gly-Ala-Lys enthalten. [s.n.], 1985.

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Darmstadt, Technische Hochschule, ed. Untersuchungen über parallele und antiparallele Tripelhelices bei Modellpeptidketten der Sequenz (Gly-Pro-Pro)n und (Pro-Pro-Gly)n. 1986.

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Book chapters on the topic "Gly-Pro"

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Jiang, Yun, Zhen-Wei Miao, and Xiao-Jie Xu. "Synthesis and ion binding properties of cyclo-[Lys(Z)-Pro-Gly-Lys(Z)-Gly]2 and cyclo-[Phe-Lys(Z)-Pro-Gly-Lys(Z)-Gly]2." In Peptides. Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-010-9069-8_14.

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Hemmasi, B., H. Willisch, W. Hiller, and E. Bayer. "Conformational studies of Boc-L-Pro-L-Pra-Gly-OMe by X-ray." In Peptides. Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2264-1_78.

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Nakatani, Masaru, Takashi Nakata, Ichizo Shinoda, Katsushige Kouge, and Hideo Okai. "Syntheses of H-Arg202-Gly-Pro-Phe-Pro-Ile-Ile-Val209-OH, corresponding to the C-terminal portion of β-casein, and its analogs." In Peptide Chemistry 1992. Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1474-5_125.

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Kusumastuti, Y., Y. Shibasaki, S. Hirohara, K. Terada, T. Ando, and M. Tanihara. "Preliminary Study on Gelation of Succinylated Poly(Pro-Hyp-Gly) and Chitosan by Polyion Complex Interaction for Cartilage Repair." In IFMBE Proceedings. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-23508-5_278.

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Shibasaki, Y., S. Hirohara, K. Terada, T. Ando, and M. Tanihara. "Collagen-Like Polypeptide Poly(Pro-Hyp-Gly) Conjugated with Fibronectin- Derived Peptides Enhances the Cell Adhesion, Migration and Stratification." In IFMBE Proceedings. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-23508-5_282.

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Krause, Jeanette A., and Drake S. Eggleston. "Molecular structure of Cbz-Ala-Val-Ser(tBu)-Gly-Pro-Phe-tBu: A linear hexapeptide containing an inverse γ-turn." In Peptides. Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2264-1_72.

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Bourguet, Carine B., and William D. Lubell. "Synthesis and Alkylation of Aza-Gly-Pro Building Blocks of Peptidomimetic Libraries for Developing Prostaglandin F2α Receptor Modulators as Therapeutics to Inhibit Preterm Labor." In Peptide Libraries. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-2020-4_6.

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Enna, S. J., and David B. Bylund. "pGlu-His-Pro-Gly-NH2." In xPharm: The Comprehensive Pharmacology Reference. Elsevier, 2007. http://dx.doi.org/10.1016/b978-008055232-3.63617-7.

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Jahn, R., and T. C. Südhof. "Synaptophysin protein family." In Secretory Pathway. Oxford University PressOxford, 1994. http://dx.doi.org/10.1093/oso/9780198599425.003.0128.

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Abstract cDNAs encoding synaptophysin have been sequenced from several mammalian species (GenBank accession number for rat cDNA: X06177) and from Torpedo1·5They encode a protein of approximately 34,000 Daltons with four predicted transmembrane segments and the C- and N-termini facing the cytoplasm124·5. No signal sequence is observed, similar to all other synaptic vesicle membrane proteins cloned so far. The sequence contains two potential glycosylation sides and four cysteine residues, all located in the luminal loops. The cytoplasmic tail contains 10 copies of a unique pentapetpide repeat wi
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Kitaoka, Yuki, and Junji Yodoi. "Measurement of proteinaceous plasma antioxidants, low molecular weight antioxidants, and redox related compounds." In Experimental protocols for reactive oxygen and nitrogen species. Oxford University PressOxford, 2000. http://dx.doi.org/10.1093/oso/9780198506683.003.0013.

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Abstract Adult T cell leukaemia-derived factor (ADF), originally defined as an inducer of interleukin 2 receptor/ot chain (IL-2R/p55) of human T-lymphotropic virus type I (HTLV-I) positive T cells, is a human analogue of the redox-active coenzyme thioredoxin of Escherichia coli. ADF/thioredoxin contains a redoxactive dithiol (-Cys-Gly-Pro-Cys-) and has a variety of biological activities as a hydrogen donor, including dithiol-dependent reducing activity and radical scavenging activity.
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Conference papers on the topic "Gly-Pro"

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СЕРГАЛИЕВА, М. У., В. Х. МУРТАЛИЕВА та М. А. САМОТРУЕВА. "ОЦЕНКА НЕЙРОТРОПНОГО ДЕЙСТВИЯ ТЕТРАПЕПТИДА ARG-PRO-GLY-PRO". У ФАРМОБРАЗОВАНИЕ-2023. Voronezh State University, 2023. http://dx.doi.org/10.17308/978-5-9273-3827-6-2023-632-635.

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Целью исследования явилось изучение нейротропного действия пептида Arg-Pro-Gly-Pro в условиях гиперфункции щитовидной железы. Исследование проведено на крысах-самцах, разделенных на группы: I-ая -интактные крысы (контроль); II-ая - особи с экспериментальным гипертиреозом; III-я - животные с индуцированным гипертиреозом, получавшие Arg-Pro-Gly-Pro. Поведенческую активность грызунов изучали, применяя тест «Открытое поле». В ходе исследования установлено, что тетрапептид Arg-Pro-Gly-Pro на фоне гиперфункции щитовидной железы оказывает нейротропное действие на поведенческий статус лабораторных жив
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Ismailova, T. I., R. M. Abbasli, and L. I. Ismailova. "The spatial structure and electron properties of the Gly-Glu-His-Phe-Pro-Gly-Pro molecule." In 2009 International Conference on Application of Information and Communication Technologies (AICT). IEEE, 2009. http://dx.doi.org/10.1109/icaict.2009.5372586.

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Suveizdyte, Kornelija, Dhiren F. Patel, Chloe J. Pyle, et al. "Overzealous degradation of collagen fragment Pro-Gly-Pro by leukotriene A4 hydrolase (LTA4H) perpetuates fibrosis in IPF." In ERS Lung Science Conference 2022 abstracts. European Respiratory Society, 2022. http://dx.doi.org/10.1183/23120541.lsc-2022.127.

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Solares, Santiago D., Jonathan Chang, Joonil Seog, and Adam U. Kareem. "Utilization of Simple Scaling Laws for Modulating Tip-Sample Interaction Forces in Aqueous Environment AFM Characterization: Application to the Self-Assembly of Protein Polymers." In ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/detc2011-47199.

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We have recently reported on experimental observations of silk-elastin-like protein polymers (SELPs) that self-assembled into 1-dimensional nanofibers on mica surfaces upon application of a mechanical stimulus with atomic force microscopy (AFM) in water. SELPs are genetically engineered block co-polymers made of silk-like blocks (Gly-Ala-Gly-Ala-Gly-Ser) from Bombyx mori (silkworm) and elastin-like blocks (Gly-Val-Gly-Val-Pro) from mammalian elastin. The experiment consisted of adsorbing the protein polymer onto a freshly cleaved mica surface, followed by AFM characterization under different s
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Tokunaga, F., T. Miyata, T. Nakamura, T. Morita, and S. Iwanaga. "LIPOPOLYSACCHARIDE-SENSITIVE SERINE-PROTEASE ZYMOGEN (FACTOR C) OF LIMULUS HEMOCYTES: IDENTIFICATION AND ALIGNMENT OF PROTEOLYTIC FRAGMENTS PRODUCED DURING THE ACTIVATION SHOW THAT IT IS A NOVEL TYPE OF SERINE-PROTEASE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644609.

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Limulus clotting factor, factor C, is a lipopolysaccharide (LPS)-sensitive serine-protease zymogen present in the hemocytes. It is a two-chain glycoprotein (M.W. = 123,000) composed of a heavy chain (M.W. = 80,000) and a light chain (M.W. = 43,000) T. Nakamura et al. (1986) Eur. J. Biochem. 154, 511-521 .On further studies of this zymogen, a single-chain factor C (M.W. = 123,000) was identified by Western blotting technique. The heavy chain had an NH2-terminal sequence of Ser-Gly-Val-Asp-, which was consistent with the NH2-terminal sequence of the single-chain factor C, indicating that the hea
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León, Iker, José Alonso, Santiago Mata, Carlos Cabezas, and Elena Alonso. "A PICTURE OF THE GLY-PRO SEQUENCE OF COLLAGEN IS CAUGHT IN GAS PHASE." In 73rd International Symposium on Molecular Spectroscopy. University of Illinois at Urbana-Champaign, 2018. http://dx.doi.org/10.15278/isms.2018.ml02.

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Huan, X., Y. Legrand, J. Soria, C. Soria, J. Caen, and J. Fareed. "STUDIES ON THE ANTITHROMBOTIC ACTIONS OF A COLLAGEN PEPTIDE IN A DEFINED MODEL OF VENOUS THROMBOSIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644496.

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The synthesis and biologic actions of a collagen peptide Lys-Pro-Gly-Glu-Pro-Gly-Pro-Lys (CP) were first reported by Fauvel, et. al. in 1979. This peptide was found to inhibit collagen induced aggregation of platelets and to modulate clot formation and specific collagen induced fibrinogen binding by platelets. CP exhibited antithrombotic actions in a modified venous stasis thrombosis model (rabbit) against defined thrombogenic challenges, (ED50;(IV) 0.5 − 2.5 mg/kg; (SC) 2.5 − 7.5 mg/kg). The antithrombotic actions of this peptide exhibited a short half-life (10 minutes) after IV administratio
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Tans, G., T. Janssen-Claessen, J. Rosing, and J. H. Griffin. "APPLICATION OF SPECIFIC SERINE PROTEASE INHIBITORS IN ASSAYS FOR ACTIVATED CONTACT FACTORS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643301.

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We developed amidolytic assays to determine human Factor Xlla, Factor XIa and plasma kallikrein in mixtures containing variable amounts of each enzyme. The commercially available chromogenic substrates pro-phe-arg-pNA (S2302 or chromozym PK), glu-pro-arg-pNA (S2366), ile-glu-(piperidyl)-gly-arg-pNA (S2337), and ile-glu-gly-arg-pNA (S2222) were tested for their suitability as substrates in these assays. 8-Factor Xlla, Factor XIa and plasma kallikrein each exhibit considerable activity towards a number of these substrates. This precludes direct quantitation of the individual enzymes when large a
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Bellucci, S., E. Cambau, B. Candalot, and J. P. Caen. "PHARMACOLOGICAL STUDIES OF PLATELET ANTIAGGREGANTS USING AN IN VITRO MODEL OF PRIMARY HEMOSTASIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643434.

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We used a new device simulating in vitro primary haemostasis : more precisely the reactivity of blood to collagen and ADP. Thus an artificial vessel was created consisting of two main parts : a glass capillary (ID 140 um, length 16 mm, siliconized) simulating the haemodynamic resistance of an arteriole and an aperture (ID 150 um) reflecting the injured part of a cut arteriole. This aperture was performed in a cellulose acetate filter covered with collagen type I (3 mg/ml) to provide a defined surface for the adhesion of platelets and soaked with ADP in a concentration similar to that of injure
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Barnes, M. J., C. M. Fitzsimmons, and L. F. Morton. "THE STRUCTURE OF PLATELET-REACTIVE SITES IN COLLAGENS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643588.

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Collagen-induced platelet aggregation is an essential step in haemostasis and may be important in thrombosis, particularly that associated with the atherosclerotic plaque. We have located platelet-binding sites in collagen by fragmentation of the molecule with cyanogen bromide (CB) and measurement of the platelet aggregatory activity of the fragments following their renaturation to restore triple-helical configuration and polymerisation to introduce quaternary structure. We have found a high1y-reactive site in collagen type III located in the peptide α1(III)CB4 which was active at a concentrat
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