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Journal articles on the topic 'Gly-Pro'

Author: Grafiati

Published: 11 December 2022

Last updated: 31 July 2025

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1

GUANTIERI, V., A. M. TAMBURRO, D. CABROL, H. BROCH, and D. VASILESCU. "Conformational studies on polypeptide models of collagen. Poly(Gly-Pro-Val), poly(Gly-Pro-Met), poly(Gly-Val-Pro) and poly(Gly-Met-Pro)." International Journal of Peptide and Protein Research 29, no. 2 (2009): 216–30. http://dx.doi.org/10.1111/j.1399-3011.1987.tb02248.x.

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2

Шевченко, Константин Валерьевич, Татьяна Владимировна Вьюнова, Людмила Александровна Андреева, Игорь Юлианович Нагаев, Валерий Павлович Шевченко та Николай Федорович Мясоедов. "Протеолиз Pro-Gly-Pro-Leu в гиппокампе, мозжечке и коре мозга крыс при интраназальном введении". Химико-фармацевтический журнал 49, № 2 (2015): 12–17. http://dx.doi.org/10.30906/0023-1134-2015-49-2-12-17.

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Показано, что при интраназальном введении тетрапептида Pro-Gly-Pro-Leu его концентрация, а также концентрация его метаболитов (Gly-Pro-Leu, Pro-Gly-Pro, Gly-Pro и Pro-Gly) в разных отделах мозга — гиппокампе, мозжечке и коре мозга крыс — зависит от времени. Максимальное содержание меченного тритием Pro-Gly-Pro-Leu и продуктов его деградации в мозге крыс наблюдается через 40 мин и составляет 0,07 % от количества исходно введенного. Максимальная концентрация Pro-Gly-Pro-Leu в мозжечке составила 2,37 пмоль/г, в гиппокампе — 1,93 пмоль/г, в коре мозга — 0,67 пмоль/г. Распределение в этих отделах м

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3

Younes, M. E., S. Abdel Rahman, and A. Hattaba. "Synthesis of elastin-like peptides using the liquid phase method." Collection of Czechoslovak Chemical Communications 52, no. 5 (1987): 1352–55. http://dx.doi.org/10.1135/cccc19871352.

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Elastin-like peptides were synthesized by the liquid-phase method using poly(ethylene glycol) monomethyl ether (PEGM) (m.w. 5 000) as solubilizing support which provides an alternative possibility for conformational studies and spectroscopic measurements in solution. The following sequences were synthesized: Boc-Ala-Pro-Gly-Val-APEGM, Boc-Ala-Pro-Gly-Val-Gly-Val-APEGM, Boc-Ala-Pro-Gly-Val-Ala-Pro-Gly-Val-Gly-Val-APEGM, Boc-Ala-Pro-Gly-Val-Gly-Val-Ala-Pro-Gly-Val-Gly-Val-APEGM.

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4

Okuyama, Kenji, Tatsuya Kawaguchi, Masaki Shimura, Keiichi Noguchi, Kazunori Mizuno, and Hans Peter Bächinger. "Crystal structure of the collagen model peptide (Pro-Pro-Gly)4-Hyp-Asp-Gly-(Pro-Pro-Gly)4at 1.0 Å resolution." Biopolymers 99, no. 7 (2013): 436–47. http://dx.doi.org/10.1002/bip.22198.

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5

Jiravanichanun, Nattha, Chizuru Hongo, Guanghan Wu, et al. "Unexpected Puckering of Hydroxyproline in the Guest Triplets, Hyp-Pro-Gly and Pro-alloHyp-Gly Sandwiched between Pro-Pro-Gly Sequence." ChemBioChem 6, no. 7 (2005): 1184–87. http://dx.doi.org/10.1002/cbic.200500055.

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6

Shevchenko, K. V., I. Yu Nagaev, L. A. Andreeva, V. P. Shevchenko, and N. F. Myasoedov. "Stability of prolin-containing peptides in biological media." Biomeditsinskaya Khimiya 65, no. 3 (2019): 180–201. http://dx.doi.org/10.18097/pbmc20196503180.

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New data on peptide drugs have been summarized; their high stability is due to both the introduction of Pro-Gly-Pro in various amino acid sequences and the modification of the glyproline fragment itself. Pro-Gly-Pro-Leu, ACTH(6-9)Pro-Gly-Pro, 5-oxo-Pro-Arg-Pro and 5-oxo-Pro-His-Pro-NH2 were used as proline-containing peptides. Tritiated peptides were obtained: Pro-Gly-Pro-Leu with specific radioactivity of 135 Ci/mmol, ACTH(6-9)Pro-Gly-Pro – 26 Ci/mmol, 5-oxo-Pro-Arg-Pro – 60 Ci/mmol and 5-oxo-Pro-His-Pro-NH2 – 75 Ci/mmol. The concentration of Pro-Gly-Pro-Leu, ACTH(6-9)Pro-Gly-Pro, 5-oxo-Pro-A

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7

ROTH, W., and E. HEIDEMANN. "TRIPLE HELIX COIL TRANSITION OF A BLOCKPOLYMER WITH THE SEQUENCE BOC-(GLY-PRO-PRO)5-(GLY-PRO-LEU)5-(GLY-PRO-PRO)5-NH2." International Journal of Peptide and Protein Research 17, no. 5 (2009): 527–30. http://dx.doi.org/10.1111/j.1399-3011.1981.tb02024.x.

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8

Shevchenko, V. P., L. A. Andreeva, I. Yu Nagaev, and N. F. Myasoedov. "Peptide derivatives of some physiologically active substances." Доклады Академии наук 487, no. 1 (2019): 41–44. http://dx.doi.org/10.31857/s0869-5652487141-44.

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The synthesis of Boc-Gly-Pro-Dox, Boc-Gly-Pro-DOPA, Boc-Gly-Pro-Srt and their deuterated analogs was carried out. It was shown that these condensations proceed with side reactions, which could be minimized by optimizing the conditions for the synthesis. The most universal approach to the synthesis of Boc-Gly-Pro-Dox, Boc-Gly-Pro-DOPA, Boc-Gly-Pro-Srt and their deuterated analogs is condensation of Boc-Gly-Pro or Boc-Gly-[2H]Pro with amino groups of dopamine, serotonin and doxorubicin. It was found that for the introduction of hydrogen isotopes in ΔPro, it is advisable to hydrogenate its aqueou

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9

Liao, Wenzhen, Longjian Gu, Yamei Zheng, et al. "Analysis of the quantitative structure–activity relationship of glutathione-derived peptides based on different free radical scavenging systems." MedChemComm 7, no. 11 (2016): 2083–93. http://dx.doi.org/10.1039/c6md00006a.

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In the present study, eleven glutathione-derived peptides, including Glu-Cys-His, Pro-Leu-Gly, Pro-Cys-Gly, Phe-Lys-Leu, Leu-His-Gly, Lys-Leu-Glu, Lys-Val-His, Tyr-Glu-Gly, Tyr-His-Leu, Gly-Glu-Leu and Gly-Pro-Glu, were designed.

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10

Шевченко, Константин Валерьевич, Игорь Юлианович Нагаев, Людмила Александровна Андреева, Валерий Павлович Шевченко та Николай Федорович Мясоедов. "Перспективы использования интраназального введения для доставки нейропептидов в головной мозг". Химико-фармацевтический журнал 53, № 2 (2019): 3–15. http://dx.doi.org/10.30906/0023-1134-2019-53-2-3-15.

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Преимуществами интраназального метода введения (ИМВ) лекарственных препаратов является неинвазивность, безболезненность, простота и удобство применения. Показаны основные подходы, связанные с решением задач по эффективной доставке в мозг пептидов через слизистую носа с учетом особенности анатомии и физиологии носовой полости. ИМВ позволяет обойти гематоэнцефалический барьер, но сталкивается с проблемой протеолиза пептидов под действием компонентов слизи обонятельного эпителия — с ферментативным барьером. В качестве реперных пептидов для экспериментов in vivo использовали Pro-Gly-Pro, Pro-Gly-P

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11

Sergalieva, M. U., A. A. Tsibizova, M. A. Samotrueva, L. A. Andreeva, and N. F. Myasoedov. "Screening studies of the psychotropic activity of regulatory peptides under conditions of thyroid hyperfunction." Сибирский научный медицинский журнал 45, no. 1 (2025): 122–28. https://doi.org/10.18699/ssmj20250113.

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The work is devoted to the screening study of the psychotropic activity of regulatory peptides of a number of glyprolins and melanocortins in conditions of thyroid hyperfunction. Material and methods. The study was carried out on male rats divided into groups: I – intact rats (control); II – individuals with experimental hyperthyroidism; III, IV, V, VI, VII and VIII – animals with induced hyperthyroidism receiving Thr-Lys-Pro-Arg-Pro-Gly-Pro, ACTH(4-7)-Pro-Gly-Pro, ACTH(6-9)-Pro-Gly-Pro, Pro-Gly-Pro, Pro-Gly-Pro-Leu, Arg-Pro-Gly-Pro, Pro-Gly-Pro-Val and Met-Thr-Lys-Pro-Arg-Pro-Gly-Pro, respect

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12

Gale, J. S., J. E. A. McIntosh та R. P. McIntosh. "Peptidyl-glycine α-amidating mono-oxygenase activity towards a gonadotropin-releasing-hormone C-terminal peptide substrate, in subcellular fractions of sheep brain and pituitary". Biochemical Journal 251, № 1 (1988): 251–59. http://dx.doi.org/10.1042/bj2510251.

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The amidation of a synthetic peptide D-Tyr-Pro-Gly-Gly by sheep hypothalamic and pituitary preparations was measured. This substrate was designed as a glycine-extended C-terminal peptide analogue of gonadotropin-releasing hormone (GnRH) to test the ability of these tissues to convert the product produced by cleavage of the GnRH prohormone into the active amidated decapeptide. An alpha-amidating activity capable of converting D-125I-Tyr-Pro-Gly-Gly into D-125I-Try-Pro-Gly-NH2 was identified in crude synaptosomal and neurosecretory-granule fractions from hypothalamus and anterior-pituitary secre

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13

Kluh, Ivan, Ladislav Morávek, and Manfred Pavlík. "Amino acid sequence of cyanogen bromide fragment CB5 of human hemopexin." Collection of Czechoslovak Chemical Communications 54, no. 3 (1989): 803–10. http://dx.doi.org/10.1135/cccc19890803.

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Cyanogen bromide fragment CB5 represents the region of the polypeptide chain of hemopexin between the fourth and fifth methionine residue (residues 232-352). It contains 120 amino acid residues in the following sequence: Arg-Cys-Ser-Pro-His-Leu-Val-Leu-Ser-Ala-Leu-Thr-Ser-Asp-Asn-His-Gly-Ala-Thr-Tyr-Ala-Phe-Ser-Gly-Thr-His-Tyr-Trp-Arg-Leu-Asp-Thr-Ser-Arg-Asp-Gly-Trp-His-Ser-Trp-Pro-Ile-Ala-His-Gln-Trp-Pro-Gln-Gly-Pro-Ser-Ala-Val-Asp-Ala-Ala-Phe-Ser-Trp-Glu-Glu-Lys-Leu-Tyr-Leu-Val-Gln-Gly-Thr-Gln-Val-Tyr-Val-Phe-Leu-Thr-Lys-Gly-Gly-Tyr-Thr-Leu-Val-Ser-Gly-Tyr-Pro-Lys-Arg-Leu-Glu-Lys-Glu-Val-Gly

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14

Zhang, Jing-Bo, Yu-Qin Zhao, Yu-Mei Wang, Chang-Feng Chi, and Bin Wang. "Eight Collagen Peptides from Hydrolysate Fraction of Spanish Mackerel Skins: Isolation, Identification, and In Vitro Antioxidant Activity Evaluation." Marine Drugs 17, no. 4 (2019): 224. http://dx.doi.org/10.3390/md17040224.

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A previous report indicated that collagen hydrolysate fraction (F7) from Spanish mackerel (Scomberomorous niphonius) skins showed high reducing power and radical scavenging activities on 2,2-Diphenyl-1-picrylhydrazyl (DPPH) (EC50 value of 1.57 mg/mL) and hydroxyl (EC50 value of 1.20 mg/mL). In this work, eight peptides were isolated from F7 and identified as Gly-Pro-Tyr (GPY, 335.31 Da), Gly-Pro-Thr-Gly-Glu (GPTGE, 459.47 Da), Pro-Phe-Gly-Pro-Asp (PFGPD, 531.52 Da), Gly-Pro-Thr-Gly-Ala-Lys (GPTGAKG, 586.65 Da), Pro-Tyr-Gly-Ala-Lys-Gly (PYGAKG, 591.69 Da), Gly-Ala-Thr-Gly-Pro-Gln-Gly (GATGPQG,

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15

Yasmin, Hasina, Mohammed Shafikur Rahman, Takayuki Shibata, Tsutomu Kabashima, and Masaaki Kai. "A Novel Fluorometric Method for the Selective Determination of Pro-Gly and Pro-Gly-Pro." International Journal of Peptide Research and Therapeutics 20, no. 4 (2014): 441–46. http://dx.doi.org/10.1007/s10989-014-9406-z.

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16

Stroup, Adam N., Arlene L. Rockwell, and Lila M. Gierasch. "Solution conformations of two flexible cyclic pentapeptides:cyclo(Gly-Pro-D-Phe-Gly-Ala) andcyclo(Gly-Pro-D-Phe-Gly-Val)." Biopolymers 32, no. 12 (1992): 1713–25. http://dx.doi.org/10.1002/bip.360321213.

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17

Masson, Antoine, Michael Z. Kamrath, Marta A. S. Perez, et al. "Infrared Spectroscopy of Mobility-Selected H+-Gly-Pro-Gly-Gly (GPGG)." Journal of The American Society for Mass Spectrometry 26, no. 9 (2015): 1444–54. http://dx.doi.org/10.1007/s13361-015-1172-4.

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18

Rahman, S. Abdel, M. Elsafty та A. Hattaba. "Circular dichroism and infrared study of β-turn formation in repeat peptides of elastin". Collection of Czechoslovak Chemical Communications 52, № 5 (1987): 1356–61. http://dx.doi.org/10.1135/cccc19871356.

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The conformation of elastin-like peptides Boc-Ala-Pro-Gly-Val-APEGM, Boc-Ala-Pro-Gly-Val-Gly-Val-APEGM, Boc-Ala-Pro-Gly-Val-Ala-Pro-Gly-Val-Gly-Val-APEGM, Boc-Ala-Pro-Gly-Val-Gly-Val-Ala-Pro-Gly-Val-Gly-Val-APEGM were examined in solution using circular dichroism at 30 °C, 50 °C, and 70 °C and in solid state by IR at room temperature. The studies show that the β-turn is a significant conformational feature for peptides under investigation in solution at 30 °C and 50 °C, but at 70 °C the tetra, hexa, and decapeptides show the CD feature characteristic of the β-structure while the dodecapeptide

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19

Maffia, M., T. Verri, A. Danieli, et al. "H(+)-glycyl-L-proline cotransport in brush-border membrane vesicles of eel (Anguilla anguilla) intestine." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 272, no. 1 (1997): R217—R225. http://dx.doi.org/10.1152/ajpregu.1997.272.1.r217.

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A plasma membrane H(+)-glycyl-L-proline (Gly-L-Pro) cotransport mechanism has been identified in isolated eel intestinal brush-border membrane vesicles (BBMV) by both measuring radiolabeled Gly-L-Pro uptake and monitoring Gly-L-Pro-dependent H+ influx with the pH-sensitive dye acridine orange. The application of an inside negative membrane potential resulted in increasing Gly-L-Pro uptake, as well as the application of inwardly directed H+ gradient (although only when an inside negative membrane potential was present). Furthermore, vesicular H+ influx was found specifically associated with the

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20

Kravchenko, E. V., L. M. Olgomets, O. N. Savanets, et al. "Effect of proline-containing oligopeptides on the behavior of outbred ICR mice in the Forced Swim Test." Proceedings of the National Academy of Sciences of Belarus, Medical series 20, no. 3 (2023): 256–64. http://dx.doi.org/10.29235/1814-6023-2023-20-3-256-264.

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The effect of proline-containing oligopeptides N-Ac-DSer-Pro-DArg-Gly-NH2 (B-4), N-Ac-Trp-Pro-Arg-Gly-NH2 (B-5), N-Ac-Tyr-Pro-Arg-Gly-NH2 (B-7), and Pro-Gly on the behavior of male ICR mice in the Forced Swim Test was studied. N-Ac-DSer-Pro-DArg-Gly-NH2 (1.0 mcg/kg, i.n) increased the intensity of active swimming, most pronounced – during the last 2 minutes of testing (maximum fatigue period), i.e., it prevented the behavior of “despair”.

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21

Nagarajan, V., S. Kamitori, and K. Okuyama. "Structure analysis of collagen-model peptides with (Pro-Pro-Gly) and (Pro-Hyp-Gly) sequence repeats." Nihon Kessho Gakkaishi 40, Supplement (1998): 189. http://dx.doi.org/10.5940/jcrsj.40.supplement_189.

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22

Zhi, Mingyu, Yanan Li, Shella Permatasari Santoso, Fangyuan Chen, and Guangrong Huang. "Complex formation constant of ferric ion with Gly, Pro-Hyp and Gly-Pro-Hyp." RSC Advances 8, no. 48 (2018): 27157–62. http://dx.doi.org/10.1039/c8ra04763d.

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23

Skopicki, H. A., K. Fisher, D. Zikos, R. Bloch, G. Flouret, and D. R. Peterson. "Multiple carriers for dipeptide transport: carrier-mediated transport of glycyl-L-proline in renal BBMV." American Journal of Physiology-Renal Physiology 261, no. 4 (1991): F670—F678. http://dx.doi.org/10.1152/ajprenal.1991.261.4.f670.

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To determine whether multiple carriers are responsible for luminal uptake of glycyl-L-proline (Gly-Pro) in the renal proximal tubule, transport of Gly-[3H]Pro was measured in brush-border membrane vesicles (BBMV). A Line-weaver-Burk analysis of Michaelis-Menten kinetics revealed the presence of two carriers: a lower affinity, higher capacity carrier (Km = 1.3 x 10(-2) M; Vmax = 4.6 x 10(-8) mol.mg-1.min-1) and a higher affinity, lower capacity carrier (Km = 2.7 x 10(-7) M; Vmax = 7.8 x 10(-13) mol.mg-1.min-1). The dipeptides Gly-Sar, beta Ala-His, and pyroGlu-His competitively inhibited the lo

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24

Raghothama, Srinivasa Rao, Satish Kumar Awasthi та Padmanabhan Balaram. "β-Hairpin nucleation by Pro-Gly β-turns. Comparison of D-Pro-Gly and L-Pro-Gly sequences in an apolar octapeptide". Journal of the Chemical Society, Perkin Transactions 2, № 1 (1998): 137–44. http://dx.doi.org/10.1039/a703331a.

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25

Шевченко, Валерий Павлович, Людмила Александровна Андреева, Константин Валерьевич Шевченко, Игорь Юлианович Нагаев та Николай Федорович Мясоедов. "Исследование мембранотропных свойств ацилированных пептидных производных дофамина и серотонина при использовании метода PAMPA". Химико-фармацевтический журнал 56, № 5 (2022): 29–33. http://dx.doi.org/10.30906/0023-1134-2022-56-5-29-33.

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Синтезированы ацилированные лауриновой (LA) и олеиновой (OA) кислотой пептидные производные дофамина (DA) и серотонина (5-HT, 5-гидрокситриптамин) LA-Gly-Pro-DA, LA-Gly-Pro-5-HT, OA-Gly-Pro-DA, OA-Gly-Pro-5-HT. Разработан масс-спектрометрический метод оценки содержания производных дофамина и серотонина в фосфатно-солевом буфере (PBS Am-E404-100, pH 7,4). Показана возможность проникновения этих соединений через искусственные мембраны. Использование смеси этих соединений позволило создать ситуацию, при которой диффузия молекул производных дофамина и серотонина через мембрану происходила в резуль

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26

Valle, Giovanni, Marco Crisma, Kuo-Long Yu, Claudio Toniolo, Ram K. Mishra та Rodney L. Johnson. "Synthesis and X-ray diffraction analysis of the tetrazole peptide analogue Pro-LeuΨ[CN4]Gly-NH2". Collection of Czechoslovak Chemical Communications 53, № 11 (1988): 2863–76. http://dx.doi.org/10.1135/cccc19882863.

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The synthesis of an analogue of the neuropharmacologically active peptide Pro-Leu-Gly-NH2 in which the Leu-Gly peptide bond has been replaced with a tetrazole moiety was carried out. The molecular and crystal structure of the tetrazole analogue Pro-Leuψ[CN4]Gly-NH2 was determined by X-ray diffraction and a comparison was made with the published X-ray structure of Pro-Leu-Gly-NH2. The tetrazole annular system turns out to be a good conformationally-restricted replacement for the cis-peptide bond in terms of bond lengths, bond angles and the ω torsion angle. The molecule was found to be folded a

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27

MUNEGUMI, T. "Thermal Synthesis of Polypeptides from N-t-Butyloxycarbonyltripeptide Derivatives without Reactive Side Chains." Asian Journal of Chemistry 35, no. 11 (2023): 2797–808. http://dx.doi.org/10.14233/ajchem.2023.29585.

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The thermal reactions of N-t-butyloxycarbonyl-aspartic acid (Boc-Asp-OH) and some N-t-butyloxycarbonyl derivatives of peptides in which the C-terminal is an aspartic residue as a reactive residue in Boc-Gly-Gly-L-Asp-OH are known. The two carboxy groups at C- zerminal are believed to form an anhydride or give peptide bonds directly. This research reports the thermal reactions of N-Boc-tripeptide derivatives such as Boc-Pro-Pro-Gly-OH, Boc-Pro-Pro-Gly-NH2, Boc-Pro-Pro-Gly-OCH3 and Boc-Ala- Ala-Ala-OH with a carboxy group at C-terminal. Thermal reactions were carried out at a constant temperatur

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28

Tsibizova, A. A., M. U. Sergalieva, L. A. Andreeva, O. A. Bashkina, N. F. Myasoedov, and M. A. Samotrueva. "Psychomodulatory and anxiolytic effects of ACTH(4-7)-Pro-Gly-Pro and ACTH(6-9)-Pro-Gly-Pro against the background of experimental model of thyroid hyperfunction." Сибирский научный медицинский журнал 44, no. 1 (2024): 197–203. http://dx.doi.org/10.18699/ssmj20240119.

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The experimental study is devoted to the identification of possible psychomodulatory and anxiolytic effects of ACTH(4- 7)-Pro-Gly-Pro and ACTH(6-9)-Pro-Gly-Pro under conditions of thyroid hyperfunction. Material and methods. The experiment was performed on white male rats, which were divided into groups: I – control; II – rats with hyperthyroidism model, III and IV – animals receiving ACTH(4-7)-Pro-Gly-Pro (Semax) and ACTH(6-9)-Pro-Gly-Pro at doses of 174 and 178 μg/kg/day, respectively, for 21 days against the background of hyperthyroidism. The development of experimental hyperthyroidism in a

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29

LeBrasseur, Nicole. "Pro and Gly for elasticity." Journal of Cell Biology 175, no. 6 (2006): 843. http://dx.doi.org/10.1083/jcb.1756rr1.

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30

Scatturin, A., A. M. Tamburro, A. Pra, and E. Bordignon. "CONFORMATIONAL STUDIES ON SEQUENTIAL POLYPEPTIDES. PART VI. STRUCTURAL INVESTIGATIONS ON (Pro-Leu-Gly)10, (Pro-Leu-Gly)n AND (Leu-Pro-Gly)n." International Journal of Peptide and Protein Research 7, no. 6 (2009): 425–35. http://dx.doi.org/10.1111/j.1399-3011.1975.tb02463.x.

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31

Shevchenko, K. V., L. A. Andreeva, I. Yu Nagaev, V. P. Shevchenko, and N. F. Myasoedov. "Study of stability of proline-containing derivatives of dopamine and serotonin in the biological media in vitro experiments." Biomeditsinskaya Khimiya 65, no. 6 (2019): 498–506. http://dx.doi.org/10.18097/pbmc20196506498.

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Boc-Gly-Pro-DP, Z-Gly-Pro-DP, LA-Gly-Pro-DP, Boc-Gly-Pro-Srt, Z-Gly-Pro-Srt were synthesized for the first time. The stability of these compounds in the presence of leucine aminopeptidase, carboxypeptidase Y, carboxypeptidase B and proline endopeptidase (PEP) was determined. It turned out that the compounds are stable in the presence of aminopeptidases and carboxypeptidases. In the presence of PEP, dopamine (DP) and serotonin (Srt) are cleaved from the synthesized preparations. Thus, new proline-containing Srt and DP derivatives were obtained, Srt and DP could be gradually released from them.

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ZERKOUT, S., V. DUPONT, A. AUBRY та ін. "Turn induction by N-aminoproline Comparison of the Gly-Pro-Gly and Glyψ[CO-NH-N]Pro-Gly sequences". International Journal of Peptide and Protein Research 44, № 4 (2009): 378–87. http://dx.doi.org/10.1111/j.1399-3011.1994.tb01023.x.

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Di Blasio, Benedetto, Ettore Benedetti, Vincenzo Pavone, et al. "Bicyclic peptides: Solid state conformation of cyclo(Glu-Leu-Pro-Gly-Lys-Leu-Pro-Gly)cyclo(1?-5?)Gly." Biopolymers 30, no. 5-6 (1990): 509–16. http://dx.doi.org/10.1002/bip.360300504.

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Gallistl, Siegfried, Wolfgang Muntean, and Werner Zenz. "Gly-Pro-Arg-Pro (GPRP) enhances free thrombin." Thrombosis Research 78, no. 6 (1995): 547–50. http://dx.doi.org/10.1016/0049-3848(95)e0088-8.

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Weinberger, Barry, Nazeeh Hanna, Jeffrey D. Laskin, et al. "Mechanisms Mediating the Biologic Activity of Synthetic Proline, Glycine, and Hydroxyproline Polypeptides in Human Neutrophils." Mediators of Inflammation 2005, no. 1 (2005): 31–38. http://dx.doi.org/10.1155/mi.2005.31.

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The accumulation of neutrophils at sites of tissue injury or infection is mediated by chemotactic factors released as part of the inflammatory process. Some of these factors are generated as a direct consequence of tissue injury or infection, including degradation fragments of connective tissue collagen and bacterial- or viral-derived peptides containing collagen-related structural motifs. In these studies, we examined biochemical mechanisms mediating the biologic activity of synthetic polypeptides consisting of repeated units of proline (Pro), glycine (Gly), and hydroxyproline (Hyp), major am

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Okuyama, Kenji, Chizuru Hongo, Guanghan Wu, et al. "High-resolution structures of collagen-like peptides [(Pro-Pro-Gly)4-Xaa-Yaa-Gly-(Pro-Pro-Gly)4]: Implications for triple-helix hydration and Hyp(X) puckering." Biopolymers 91, no. 5 (2009): 361–72. http://dx.doi.org/10.1002/bip.21138.

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Yasenyavskaya, A. L., A. A. Tsibizova, L. A/ Andreeva, N. F. Myasoedov, O. A. Bashkina, and M. A. Samotrueva. "EFFECT OF GLYPROLINES ON THE LEVEL OF APOPTOTIC AND NEUROTROPHIC FACTORS UNDER CONDITIONS OF “SOCIAL” STRESS." Pharmacy & Pharmacology 9, no. 6 (2021): 485–94. http://dx.doi.org/10.19163/2307-9266-2021-9-6-485-494.

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The aim of the article was to study the effect of glyproline neuropeptide compounds Thr–Lys–Pro–Arg–Pro–Gly–Pro (Selank), Pro–Gly–Pro and Pro–Gly–Pro–Leu, on the level of apoptotic factors (caspase-3, caspase-8, the tumor necrosis factor) and neurotrophic factors (the nerve growth factor and the brain neurotrophic factor) in the blood serum of white rats under the experimental modeling of “social” stress.Materials and methods. The experimental studies were carried out on 90 nonlinear white male rats aged 6 months. By the type of behavior, in the process of “social” stress modeling, all the rat

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Шевченко, Константин Валерьевич, Людмила Александровна Андреева, Игорь Юлианович Нагаев, Валерий Павлович Шевченко та Николай Федорович Мясоедов. "Устойчивость 5-oxo-Pro-Arg-Pro, 5-oxo-Pro-His-Pro-Gly-PRONH₂ И Phe-Pro-Leu-Pro-Ala в условиях проведения экспериментов in vitro". Химико-фармацевтический журнал 52, № 8 (2018): 7–11. http://dx.doi.org/10.30906/0023-1134-2018-52-8-7-11.

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Проведено сравнение протеолиза 5-oxo-Pro-Arg-Pro, 5-oxo-Pro-His-Pro-Gly-ProNH2 и Phe-Pro-Leu-Pro-Ala в присутствии лейцинаминопептидазы, карбоксипептидаз Y и В. Оказалось, что 5-oxo-Pro-Arg-Pro устойчив в присутствии пептидаз. Только карбоксипептидаза Y в течение 26 ч гидрализует этот пептид, да и то в пределах 50 %. 5-Oxo-Pro-His-Pro-Gly-ProNH2 устойчив в присутствии лейцинаминопептидазы и карбоксипептидазы Y, в то время как Phe-Pro-Leu-Pro-Ala устойчив только в присутствии карбоксипептидазы В. В присутствии назальной слизи, крови и микросомальной фракции мозга крысы наиболее устойчивым оказа

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Asai, Tomoko T., Fumi Oikawa, Kazunobu Yoshikawa, Naoki Inoue, and Kenji Sato. "Food-Derived Collagen Peptides, Prolyl-Hydroxyproline (Pro-Hyp), and Hydroxyprolyl-Glycine (Hyp-Gly) Enhance Growth of Primary Cultured Mouse Skin Fibroblast Using Fetal Bovine Serum Free from Hydroxyprolyl Peptide." International Journal of Molecular Sciences 21, no. 1 (2019): 229. http://dx.doi.org/10.3390/ijms21010229.

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Prolyl-hydroxyproline (Pro-Hyp) and hydroxyprolyl-glycine (Hyp-Gly) appear in human blood after ingestion of collagen hydrolysate and trigger growth of fibroblasts attached on collagen gel, which has been associated with beneficial effects upon ingestion of collagen hydrolysate, such as improvement of skin and joint conditions. In the present study, inconsistent results were obtained by using different lots of fetal bovine serum (FBS). Fibroblasts proliferated in collagen gel without adding Pro-Hyp and Hyp-Gly and did not respond to addition of Pro-Hyp and Hyp-Gly, which raises doubts about co

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Wang, Jun, Satoshi Osada, Hiroaki Kodama, Tetsuo Kato, and Michio Kondo. "Synthesis and Solution Conformations of Cyclo(Pro–Leu–Gly)2and Cyclo(Pro–Leu–Gly)4." Bulletin of the Chemical Society of Japan 72, no. 3 (1999): 533–40. http://dx.doi.org/10.1246/bcsj.72.533.

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Renugopalakrishnan, V., H. Sugano, M. A. Khaled, R. S. Rapaka, and D. W. Urry. "Conformational studies of cyclohexapeptide analogs of elastin sequences: Cyclo(Ala-Pro-Gly-Ala-Pro-Gly)." International Journal of Quantum Chemistry 14, S5 (2009): 69–78. http://dx.doi.org/10.1002/qua.560140710.

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Шевченко, К. В., В. В. Безуглов, М. Г. Акимов, И. Ю. Нагаев, В. П. Шевченко та Н. Ф. Мясоедов. "СИНТЕЗ N-АЦИЛЬНЫХ ПРОИЗВОДНЫХ ПЕПТИДА PRO-GLY-PRO-LEU: ПРОТЕОЛИТИЧЕСКАЯ УСТОЙЧИВОСТЬ IN VITRO И ВЛИЯНИЕ НА КЛЕТКИ МЫШИНЫХ МАКРОФАГОВ RAW264.7, "Доклады Академии наук"". Доклады Академии Наук, № 5 (2017): 596–99. http://dx.doi.org/10.7868/s0869565217290266.

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Синтезировали ацетил-, олеоил-, арахидоноил- и докозагексаенил-производные пептида Pro-Gly-Pro-Leu с химической чистотой 99,8%. Исследовали кинетику деградации производных Pro-Gly-Pro-Leu под действием лейцинаминопептидазы, ферментов назальной слизи, ферментов микросомальной фракции клеток головного мозга и ферментов крови крыс. N-ацильные производ- ные Pro-Gly-Pro-Leu оказались более устойчивыми к действию лейцинаминопептидазы и других ферментов. Исследование цитотоксической и противовоспалительной активности препаратов на линии клеток мышиных макрофагов RAW264.7 показало, что ацилирование ол

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Samotrueva, Marina, Anna Yasenyavskaya, Alexandra Tsibizova, Liudmila Andreeva, and Nikolai Myasoedov. "EFFECTS OF GLYPROLINES ON THE BEHAVIOR OF RATSIN THE PORSOLTTEST AND EXPERIMENTALLYINDUCED SOCIALS." Archiv Euromedica 10, no. 4 (2020): 31–34. http://dx.doi.org/10.35630/2199-885x/2020/10/4.7.

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In this work we studied the effect of glyprolines on the behavior of rats under conditions of experimental social stress. White male rats 6-8 months of age were used in the experiment. Throughout the experiment all animals were kept in standard-barrier conditions. The effect of glyprolines on the behavior of white male rats was studied on the model of social stress, implying that the animals are kept in conditions of a constant sensory contact. Glyprolines (Selank, Pro-Gly-Pro, Pro-Gly-Pro-Leu) were injected to the animals Intraperitoneally at a dose of 100 μg/kg/day within 20 days. Porsolt te

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Aliev, Abil E., and Denis Courtier-Murias. "Experimental Verification of Force Fields for Molecular Dynamics Simulations Using Gly-Pro-Gly-Gly." Journal of Physical Chemistry B 114, no. 38 (2010): 12358–75. http://dx.doi.org/10.1021/jp101581h.

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Цибизова, А. А., Мариям У. Сергалиева, В. Х. Мурталиева, Л. А. Андреева, Н. Ф. Мясоедов та М. А. Самотруева. "Меланокортины как регуляторы прооксидантно-антиоксидантного баланса в условиях экспериментального гипертиреоза". Экспериментальная и клиническая фармакология 86, № 12 (2024): 27–31. http://dx.doi.org/10.30906/0869-2092-2023-86-12-27-31.

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Изучено влияние пептидных соединений меланокортиновой природы на окислительно-восстановительные процессы в ткани печени крыс на фоне гиперфункции щитовидной железы. Были сформированы экспериментальные группы (n = 10): I — контроль (интактные крысы); II — животные, получавшие пентагидрат натриевой соли L-тироксина в дозе 50 мкг/кг внутрижелудочно 42 дня (гипертиреоз); III — крысы с гипертиреозом, получавшие АКТГ(4-7)-Pro-Gly-Pro (Семакс); IV — особи с гипертиреозом, получавшие АКТГ(6-9)-Pro-Gly-Pro внутрибрюшинно ежедневно в течение 21 дня, начиная с 22 дня введения пентагидрата натриевой соли

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Larder, Christina E., Michèle M. Iskandar, and Stan Kubow. "Assessment of Bioavailability after In Vitro Digestion and First Pass Metabolism of Bioactive Peptides from Collagen Hydrolysates." Current Issues in Molecular Biology 43, no. 3 (2021): 1592–605. http://dx.doi.org/10.3390/cimb43030113.

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Collagen hydrolysates (CHs) are composed of bioactive peptides (BAPs), which possess health enhancing properties. There is a knowledge gap regarding the bioavailability of these BAPs that involves intestinal transport and hepatic first pass effects. A simulated gastrointestinal model was used to generate digesta from two CHs (CH-GL and CH-OPT), which were applied to a novel transwell co-culture of human intestinal epithelium cell line-6 (HIEC-6) and hepatic (HepG2) cells to simulate in vivo conditions of absorption and first pass metabolism. Peptide transport, hepatic first pass effects, and b

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Dauch, P., H. Barelli, J. P. Vincent, and F. Checler. "Fluorimetric assay of the neurotensin-degrading metalloendopeptidase, endopeptidase 24.16." Biochemical Journal 280, no. 2 (1991): 421–26. http://dx.doi.org/10.1042/bj2800421.

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Mcc-Pro-Leu-Gly-Pro-D-Lys-Dnp (Mcc = 3-carboxy-7-methoxycoumarin; Dnp = dinitrophenyl), a quenched fluorimetric substrate originally designed as a probe to measure Pz-peptidase (also called endopeptidase 24.15), was examined as a putative substrate of the neurotensin-degrading neutral metalloendopeptidase, endopeptidase 24.16. During the purification of endopeptidase 24.16 the neurotensin(1-10) and neurotensin(11-13) formation due to this enzyme was coeluted with Mcc-Pro-Leu-Gly-Pro-D-Lys-Dnp-hydrolysing activity. By both fluorimetric and h.p.l.c. analyses, we observed that the latter activity

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Dang, Bobo, Balamurugan Dhayalan, and Stephen B. H. Kent. "Enhanced Solvation of Peptides Attached to “Solid-Phase” Resins: Straightforward Syntheses of the Elastin Sequence Pro-Gly-Val-Gly-Val-Pro-Gly-Val-Gly-Val." Organic Letters 17, no. 14 (2015): 3521–23. http://dx.doi.org/10.1021/acs.orglett.5b01632.

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Asai, Tomoko T., Satoshi Miyauchi, Sri Wijanarti, et al. "Hydroxyprolyl-Glycine in 24 H Urine Shows Higher Correlation with Meat Consumption than Prolyl-Hydroxyproline, a Major Collagen Peptide in Urine and Blood." Nutrients 16, no. 20 (2024): 3574. http://dx.doi.org/10.3390/nu16203574.

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Background. Urinary collagen peptides, the breakdown products of endogenous collagen, have been used as biomarkers for various diseases. These non-invasive biomarkers are easily measured via mass spectrometry, aiding in diagnostics and therapy effectiveness. Objectives. The objective of this study was to investigate the effects of consuming collagen-containing meat on collagen peptide composition in human blood and urine. Methods. Ten collagen peptides in 24 h urine were quantified. Results. Prolyl-hydroxyproline (Pro-Hyp) was the most abundant peptide. Except for hydroxyprolyl-glycine (Hyp-Gl

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Li, Yan, Junru Li, Chaoxia Cheng, et al. "Study on the In Silico Screening and Characterization, Inhibition Mechanisms, Zinc-Chelate Activity, and Stability of ACE-Inhibitory Peptides Identified in Naked Oat Bran Albumin Hydrolysates." Foods 12, no. 11 (2023): 2268. http://dx.doi.org/10.3390/foods12112268.

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In this study, naked oat bran albumin hydrolysates (NOBAH) were subjected to gel chromatography with Sephadex G-15, reverse phase-high liquid performance separation, and UPLC-ESI-MS/MS identification. Six safe peptides including Gly-Thr-Thr-Gly-Gly-Met-Gly-Thr (GTTGGMGT), Gln-Tyr-Val-Pro-Phe (QYVPF), Gly-Ala-Ala-Ala-Ala-Leu-Val (GAAAALV), Gly-Tyr-His-Gly-His (GYHGH), Gly-Leu-Arg-Ala-Ala-Ala-Ala-Ala-Ala-Glu-Gly-Gly (GLRAAAAAAEGG), and Pro-Ser-Ser-Pro-Pro-Ser (PSSPPS) were identified. Next, in silico screening demonstrated that QYVPF and GYHGH had both angiotensin-I-converting enzyme (ACE) inhib

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