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Dissertations / Theses on the topic 'GlycoGag'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

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1

Bertelli, Cinzia. "Antiviral activity and retroviral counteraction of SERINC genes." Doctoral thesis, Università degli studi di Trento, 2021. http://hdl.handle.net/11572/321392.

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SERINC5 is a restriction factor for retroviruses, antagonized by Nef of primate lentiviruses, by glycoGag of Moloney Murine Leukaemia Virus (MoMLV) and by S2 of Equine Infectious Anaemia virus (EIAV). In addition, SERINC5 sensitizes HIV-1 to neutralizing antibodies (nAbs) targeting the MPER in gp41. However, since the identification of SERINC5 as an inhibitor of retrovirus infectivity, many features of the host factor await clarification, notably the molecular mechanisms of restriction and viral counteraction. Furthermore, SERINC5 cellular role beyond restriction is still obscure. This thesis

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2

Syed, Noor Afshan. "Regulation of glycogen synthase and glycogen phosphorylase by insulin in HepG2 cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ63926.pdf.

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3

Martin, Jennifer Louise. "Molecular interactions involving glycogen phosphorylase." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253306.

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4

Ghosh, Paritosh. "De Novo Glycogen Biosynthesis by a Glycogen Primer Complex in the Obliquely Striated Skeletal Muscle of Ascaris suum." Thesis, North Texas State University, 1987. https://digital.library.unt.edu/ark:/67531/metadc935639/.

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During the purification of the enzyme glycogen synthase from the muscle of the nematode Ascaris suum, approximately 70% of the glycogen synthase activity can be separated from the bulk of cellular glycogen by centrifugation for 60 min at 105,000 x . The glycogen synthase in the supernatant fraction has an Mr of 1.2 x 106 as determined by Sepharose 4B gel filtration chromatography. The glycogen synthase in this high molecular weight complex (glycogen primer complex) can be further purified by ConA-Sepharose affinity chromatography; the enzyme activity was eluted with 100 .mM a-methylmannoside.

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5

Karis, Nils David. "Design and Synthesis of 1,3-Disubstitiuted-2-Pyridones as a New Class of Glycogen Phosphorylase Inhibitors." Thesis, Griffith University, 2009. http://hdl.handle.net/10072/365791.

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Glycogen Phosphorylase (GP) is the regulatory enzyme that catalyses the first step in glycogen degradation and is a potential enzyme target for therapeutic intervention in the treatment of diabetes. The 16 amino acid C-terminal sequence of human Gl is the only known targeting subunit that binds to GPa. Blocking the interactions between Gl and GPa should reduce high blood glucose levels in a diabetic person. A segment of the 16 amino acid segment was chosen for a small molecule peptidomimetric approach, and de nova design from this segment identified the pyridone ring as apotential scaffold. Th

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6

Street, Ian Philip. "Protein - carbohydrate interactions in glycogen phosphorylase." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/25049.

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It has long been observed that some organo-fluorine compounds exhibit enhanced biological activity over their non-fluorinated precursors, however reasons for these unusual properties still remain poorly understood. An explanation which has been widely used relates to the ability of the C-F fragment of the analog to participate in hydrogen-bonding interactions with its protein receptor. For this reason, fluorinated carbohydrates have been used as hydrogen-bonding probes with a number of proteins. Thus there exists a need for a systematic investigation into the hydrogen-bonding ability of the C

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7

Stambolic, Vuk. "Regulation of glycogen synthase kinase-3." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0003/NQ27730.pdf.

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8

Fraser, Bernadine Heather. "Glycogen and glucose metabolism in cardioprotection." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0028/NQ34764.pdf.

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9

Henning, Sarah Louise. "Myocardial glycogen metabolism and its regulation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ61107.pdf.

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10

Barford, D. "Crystallographic studies on glycogen phosphorylase b." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233473.

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11

McLaughlin, P. J. "Crystallographic studies on glycogen phosphorylase b." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370290.

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12

Bichard, Claire J. F. "Synthesis of potential glycogen phosphorylase inhibitors." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260115.

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13

Hu, Shu-Hong. "Crystallographic studies on activated glycogen phosphorylase." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.291283.

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14

Stambolic, Vuk. "Regulation of glycogen synthase kinase-3." Ottawa : National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.nlc-bnc.ca/obj/s4/f2/dsk2/tape16/PQDD%5F0003/NQ27730.pdf.

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15

Higuita, Juan Carlos. "Molecular consequences of cellular UDP-glucose deficiency /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-901-3/.

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16

Hannigan, Linda L. (Linda Lucile). "Purification and characterization of glycogen synthase from Ascaris suum." Thesis, North Texas State University, 1985. https://digital.library.unt.edu/ark:/67531/metadc798067/.

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Glycogen synthase, the enzyme that catalyzes the rate-limiting reaction of glycogen syntheses has been purified and characterized from Ascaris suum muscle. Glycogen in the crude extract was digested to release the enzyme, eluted from a DE52 cellulose column and then applied to a Sepharose affinity column. The purified Ascaris enzyme was found to be homologous to the mammalian enzyme with regard to subunit and holoenzyme Mr^3 allosteric activation, substrate affinity and covalent modification. However, the association between Ascaris glycogen synthase and endogenous glycogen differed from that

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17

Mitchell, Edward Peter. "Cryocrystallographic and mechanistic studies on glycogen phosphorylase." Thesis, University of Oxford, 1994. https://ora.ox.ac.uk/objects/uuid:d562f4f6-0a93-43a6-ad74-d480697d1b8c.

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Glycogen phosphorylase (GPb) regulates the degradation of glycogen to glucose-1-phosphate and catalyses the first step of the reaction. Many studies have provided insights into the essentials of the catalytic mechanism. Previous time resolved crystallographic work using heptenitol has revealed a putative phosphate binding site at the active site of phosphorylase. Using nojirimycin tetrazole, a transition state analogue, complexed with phosphate and both T and R state GPb crystals, this work has conclusively located the phosphate binding site and the concomitant active site conformational chang

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18

Nitschke, Felix. "Phosphorylation of polyglycans, especially glycogen and starch." Phd thesis, Universität Potsdam, 2013. http://opus.kobv.de/ubp/volltexte/2013/6739/.

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Functional metabolism of storage carbohydrates is vital to plants and animals. The water-soluble glycogen in animal cells and the amylopectin which is the major component of water-insoluble starch granules residing in plant plastids are chemically similar as they consist of α-1,6 branched α-1,4 glucan chains. Synthesis and degradation of transitory starch and of glycogen are accomplished by a set of enzymatic activities that to some extend are also similar in plants and animals. Chain elongation, branching, and debranching are achieved by synthases, branching enzymes, and debranching enzymes,

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19

Duke, Elizabeth Mary Helen. "X-ray diffraction studies on glycogen phosphorylase." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336092.

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20

Kensley, Joy A. "Glycogen metabolism in Corynebacterium glutamicum ATCC 13032." Doctoral thesis, University of Cape Town, 2004. http://hdl.handle.net/11427/4279.

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Includes bibliographical references (leaves 108-123).<br>Corynebacterium glutamicum is a Gram-positive facultative aerobe particularly known for its industrial application in the synthesis of amino acids, such as L-glutamate and Llysine. The central metabolic pathways of this organism has been an area of much research by many groups. Linked to glycolysis is the synthesis of glycogen, previously considered a storage molecule of excess glucose. No information concerning the role of glycogen or its metabolism in C. glutamicum was known, and the aim of this work was to elucidate glycogen metabolis

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21

Allen, Tara J. "Characterization of vascular smooth muscle oxidative metabolism using ¹³C-isotopomer analysis of glutamate." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9988641.

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22

Puthanveetil, Prasanth Nair. "Glucocorticoid and its effect on cardiac glucose utilization." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/5038.

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Glycogen is an immediate source of glucose for cardiac tissue to maintain its metabolic homeostasis. However, its excess brings about cardiac structural and physiological impairments. Previously, we have demonstrated that in hearts from dexamethasone (DEX) treated animals, glycogen accumulation was enhanced. We examined the influence of DEX on glucose entry and glycogen synthase as a means of regulating the accumulation of this stored polysaccharide. Following DEX, cardiac tissue had limited contribution towards the development of whole body insulin resistance. Measurement of GLUT4 at the plas

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23

Watson, Kimberly Ann. "Crystallographic studies on phosphorylase : sugar recognition properties." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259849.

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24

Bruce, Mark. "Amino acid metabolism during exercise and recovery in human subjects." Thesis, Loughborough University, 2001. https://dspace.lboro.ac.uk/2134/33569.

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The depletion of muscle and liver glycogen observed during prolonged submaximal exercise is associated with fatigue. Re-synthesis of glycogen stores during the recovery period after exercise is therefore essential for the recovery of endurance exercise capacity. In recent years, attention has focussed on the supplementation of protein in addition to glucose-polymer during recovery from exercise in an attempt to further increase glycogen synthesis. The aims of the first and second studies in this thesis were to investigate the effect of glucose-polymer and amino acid ingestion, and solely amino

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25

Green, Andrew R. "Interaction of phosphorylase and glycogen synthase in the defective control of glycogen metabolism in hepatocytes from the Zucker fatty rat." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413954.

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26

Lees, Simon J. "The effects of fatigue on glycogen, glycogen phosphorylase, and calcium uptake associated with the sarcoplasmic reticulum of rat skeletal muscle." Thesis, Virginia Tech, 2000. http://hdl.handle.net/10919/35506.

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<p> Skeletal muscle fatigue can be defined as the inability to produce a desired amount of force. Fatigue can not only limit athletic performance and rehabilitation, but it can affect one's ability to perform every day activity as well. Despite extensive investigation of muscle fatigue, little is known about the exact mechanisms that result in decreased muscle performance. It likely involves several factors that are themselves dependent upon activation patterns and intensity. The process of excitation-contraction (EC) coupling is of particular importance with respect to regulation of force

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27

au, R. Jacob@central murdoch edu, and Robin Henry Jacob. "Optimising the concentration of glycogen in lamb meat." Murdoch University, 2003. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20040513.153312.

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The lamb industry is actively seeking to improve the quality of lamb meat produced in Australia. Ultimate pH (pHu) is a key determinant of red meat eating quality although this measurement has not been adopted formally by the Australian lamb meat industry. Muscle glycogen concentration is a major determinant of pHu in red meat. This thesis investigates glycogen concentration in lamb muscle and the ultimate pH (pHu) of lamb meat under commercial industry conditions as well as exploring by experimentation, some of the factors that control muscle glycogen concentration in lamb muscle. The resu

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28

Varvill, Katherine Mary. "X-ray crystallographic studies on glycogen phosphorylase b." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.352921.

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29

Mung, Kwan-long, and 蒙君朗. "Regulation of glycogen phosphorylase in hypoxic cancer cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2015. http://hdl.handle.net/10722/211148.

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Compared to normal cells, many tumor cells have to subsist in a hypoxic intratumoral environment that has an unstable supply of oxygen and nutrients including glucose. How tumor cells may survive the metabolic stress arising from tumor hypoxia is not yet fully understood. Recent studies revealed that tumor cells are able to accumulate large quantities of intracellular glycogen. Whether glycogen would serve as fuel reserve in hypoxic tumor cells is presently not clear. This question is being addressed in this study. When HeLa, HT29, HEK293 and HepG2 cells were incubated under hypoxic conditi

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30

Pascoe, David D. "Glycogen synthesis in skeletal muscle following resistive exercise." Virtual Press, 1990. http://liblink.bsu.edu/uhtbin/catkey/720309.

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The purpose of this investigation was to determine the influence of post exercise carbohydrate (CHO) intake on the rate of muscle glycogen restorage after high intensity weight resistance exercise in untrained subjects. In a cross over design, eight male subjects performed sets (mean= 8.8) of 6 single leg knee extensions at 70% of one repletion max until 50% of full knee extension was no longer possible. Total force application was equated between trials using a strain gauge interfaced to a computer. Post exercise supplementation was administered at 0 and 1 hrs consisting of either a 23% CHO s

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31

Halse, Reza. "Control of glycogen synthesis in cultured human muscle." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310172.

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32

Rusbridge, Nicholas Mercer. "Tryptic proteolysis of glycogen phosphorylase b in vitro." Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317367.

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33

McConchie, Stephen Mark. "Molecular heterogeneity of human muscle glycogen phosphorylase deficiency." Thesis, University of Liverpool, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317266.

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34

Jiang, Xianguo. "Investigating adrenoceptor regulation of the astroglial glycogen reserve." Thesis, University of Leicester, 2017. http://hdl.handle.net/2381/40130.

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There is increasing evidence that astrocytes can play crucial roles in signalling within the central nervous system. In particular, astrocytes can communicate with each other and also with neurons, the latter interaction giving rise to the concept of the “tripartite synapse”. Thus, as well as astrocytes playing a homeostatic role to maintain an optimal extracellular environment within the brain, this cell-type may play roles in an array of CNS processes, including neurotransmission and synaptic activity. Astrocytes appear to be unique within the CNS in that they can store glucose in the form o

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35

Харченко, Каріна Олександрівна, and Олександра Юріївна Кушнір. "Glycogen in the liver of streptozotocin diabetic rats." Thesis, 39th International Medical Scientific Congress, 2016. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/11214.

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36

Pimentel, Helena Isabel da Costa Antunes. "Glycogen synthase kinase 3ß modulation in axonal regeneration." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/5284.

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Mestrado em Biomedicina Molecular<br>A espinal medula de mamíferos adultos não possui capacidade de regeneração ao contrário do nervo periférico lesionado. De forma a compreender os mecanismos que potenciem a regeneração do sistema nervoso central, o modelo de lesão condicionante foi usado. Neste, uma lesão no ramo periférico dos neurónios da raiz dorsal cerca de uma semana antes de uma lesão no ramo central dos mesmos neurónios, promove a regeneração do último. Através de abordagens proteómicas concluiu-se que a Glycogen Synthase Kinase 3β (GSK3β) e proteínas que interagem com esta, estavam d

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37

Sucic, Joseph F. "Regulation of glycogen phosphorylase genes in Dictyostelium discoideum." Diss., This resource online, 1992. http://scholar.lib.vt.edu/theses/available/etd-06062008-170101/.

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38

Seibold, Gerd Michael. "Charakterisierung des Glycogen- und Maltosestoffwechsels von Corynebacterium glutamicum." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-63818.

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39

Jacob, Robin Henry. "Optimising the concentration of glycogen in lamb meat." Thesis, Jacob, Robin Henry (2003) Optimising the concentration of glycogen in lamb meat. PhD thesis, Murdoch University, 2003. https://researchrepository.murdoch.edu.au/id/eprint/110/.

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The lamb industry is actively seeking to improve the quality of lamb meat produced in Australia. Ultimate pH (pHu) is a key determinant of red meat eating quality although this measurement has not been adopted formally by the Australian lamb meat industry. Muscle glycogen concentration is a major determinant of pHu in red meat. This thesis investigates glycogen concentration in lamb muscle and the ultimate pH (pHu) of lamb meat under commercial industry conditions as well as exploring by experimentation, some of the factors that control muscle glycogen concentration in lamb muscle. The resu

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40

Jacob, Robin Henry. "Optimising the concentration of glycogen in lamb meat." Jacob, Robin Henry (2003) Optimising the concentration of glycogen in lamb meat. PhD thesis, Murdoch University, 2003. http://researchrepository.murdoch.edu.au/110/.

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The lamb industry is actively seeking to improve the quality of lamb meat produced in Australia. Ultimate pH (pHu) is a key determinant of red meat eating quality although this measurement has not been adopted formally by the Australian lamb meat industry. Muscle glycogen concentration is a major determinant of pHu in red meat. This thesis investigates glycogen concentration in lamb muscle and the ultimate pH (pHu) of lamb meat under commercial industry conditions as well as exploring by experimentation, some of the factors that control muscle glycogen concentration in lamb muscle. The resu

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41

Ferguson, Donna Catherine. "Skeletal Muscle and Hepatic Glycogen Content in Birds." Thesis, The University of Arizona, 2010. http://hdl.handle.net/10150/146240.

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42

Semiz, Sabina. "Effects of diabetes, insulin, and vanadium on regulation of glycogen synthesis : roles of glycogen synthase kinase-3 and protein phosphatase-1." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ61172.pdf.

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43

Naperalsky, Michael E. "Effect of post-exercise environmental temperature on glycogen resynthesis." The University of Montana, 2009. http://etd.lib.umt.edu/theses/available/etd-06052009-115319/.

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Hotter environments can often alter the normal exercises responses of metabolism and work performance compared to exercise in a more neutral condition. The goal of this study was to determine the effects of a hot (H) and room temperature (RT) environment on glycogen resynthesis during recovery from exercise. Recreationally active males (n = 9) completed two trials, each with 60-min of cycling exercise at 60% of maximum watts in a temperature-controlled chamber (32.6°C), followed by 4 hours of recovery at the same temperature (H) or 22.2°C (RT). Subjects were fed a carbohydrate beverage (1.8 g/

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44

Munoz, Nicole. "Glucosamine reduces glycogen storage in L6 skeletal muscle cells." Online access for everyone, 2007. http://www.dissertations.wsu.edu/Thesis/Fall2007/n_munoz_112507.pdf.

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45

Forsyth, Robert J. "The contribution of astrocyte glycogen to brain energy homeostasis." Thesis, University of Newcastle Upon Tyne, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361387.

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46

Chao, Feng Zhi. "The role of myocardial glycogen in the ischaemic heart." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/21139.

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More than half of the total mortality from coronary heart disease results from sudden cardiac death, primarily from ventricular fibrillation (VF). The metabolic changes due to ischaemia are believed to play an important role in the genesis of the arrhythmia. Two of the main mechanisms of myocyte cell death in severe ischaemia are inadequate supply of glycolytically produced adenosine triphosphate (ATP) and increased circulating catecholamines (Opie, 1993). Glucose-insulin-potassium (GIK) protects ischaemic myocardium. However, the role of glycolytic ATP is questioned by the results that precon

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47

Williamson, Brian. "Cloning and characterization of glycogen synthase from Dictyostelium discoideum." Diss., Virginia Tech, 1995. http://hdl.handle.net/10919/40221.

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48

Batts, Timothy Wayne. "The Effect of Glycogen Depletion on Sarcoplasmic Reticulum Function." Thesis, Virginia Tech, 1997. http://hdl.handle.net/10919/31095.

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The role of glycogen in endurance performance has been accepted in theory. It has been shown that higher resting muscle glycogen levels prolong endurance performance. On the other hand, low glycogen levels have been associated with fatigue. Ultimately, a personâ s muscle glycogen level dictates the duration in which an activity can be maintained at a maximal effort, after which time, performance will decrease. As of yet, there has been no evidence as to what happens to the fatigued muscle. Force production in skeletal muscle is dictated by the release and uptake of Ca2+ from the sarcopla

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49

Gardner, Graham Edwin. "Nutritional regulation of glycogen metabolism in cattle and sheep." Thesis, Gardner, Graham Edwin ORCID: 0000-0001-7499-9986 (2001) Nutritional regulation of glycogen metabolism in cattle and sheep. PhD thesis, Murdoch University, 2001. https://researchrepository.murdoch.edu.au/id/eprint/41881/.

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Dark cutting meat is a major economic problem within the cattle and sheep meat industries, and is linked to a shortage of muscle glycogen at slaughter. This study investigated various nutritional aspects involved in the regulation of muscle glycogen metabolism in sheep and cattle. Initially, a repetitive muscle biopsy protocol was developed such that changes in muscle glycogen concentration over time could be measured. An exercise model for cattle (similar to an existing model for sheep) was then developed facilitating the controlled depletion of muscle glycogen such that rates of glycogen

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50

Benedict, Michael A. "Reliability in the measurement of muscle fiber composition and the histrochemical staining for glycogen." Virtual Press, 1990. http://liblink.bsu.edu/uhtbin/catkey/722240.

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This study was conducted to determine the variation in stain Intensity between serial sections of muscle biopsies following a periodic acid Schiff (PAS) staining procedure, to assess the reliability of the PAS staining technique for the quantitation of the glycogen content in muscle fibers, and to evaluate the variability in fiber composition between repeated biopsies of the vastus lateralis (VL) muscle. Eight randomly located biopsies (4 right leg and 4 left leg) were obtained from the VL of each of 16 healthy males (26.1 ± 1.1 years). Serial cross sections, 10 um thick, were cut from each bi

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