Relevant bibliographies by topics / Glycosidases – Inhibitors – Synthesis

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Glycosidases – Inhibitors – Synthesis'

Author: Grafiati
Published: 4 June 2021
Last updated: 19 February 2022

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Journal articles on the topic "Glycosidases – Inhibitors – Synthesis"

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Le Merrer, Yves, Lydie Poitout, Jean-Claude Depezay, Isabelle Dosbaa, Sabine Geoffroy, and Marie-José Foglietti. "Synthesis of azasugars as potent inhibitors of glycosidases." Bioorganic & Medicinal Chemistry 5, no. 3 (1997): 519–33. http://dx.doi.org/10.1016/s0968-0896(96)00266-0.

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Le Merrer, Yves, Myrielle Fuzier, Isabelle Dosbaa, Marie-José Foglietti, and Jean-Claude Depezay. "Synthesis of thiosugars as weak inhibitors of glycosidases." Tetrahedron 53, no. 49 (1997): 16731–46. http://dx.doi.org/10.1016/s0040-4020(97)10096-5.

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Andriuzzi, Olivia, Christine Gravier-Pelletier, and Yves Le Merrer. "Synthesis of C8-glycomimetics as potential glycosidases inhibitors." Tetrahedron Letters 45, no. 43 (2004): 8043–46. http://dx.doi.org/10.1016/j.tetlet.2004.08.172.

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Puet, Alejandro, Gema Domínguez, Francisco Javier Cañada, and Javier Pérez-Castells. "Synthesis and Evaluation of Novel Iminosugars Prepared from Natural Amino Acids." Molecules 26, no. 2 (2021): 394. http://dx.doi.org/10.3390/molecules26020394.

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Cyclopropanated iminosugars have a locked conformation that may enhance the inhibitory activity and selectivity against different glycosidases. We show the synthesis of new cyclopropane-containing piperidines bearing five stereogenic centers from natural amino acids l-serine and l-alanine. Those prepared from the latter amino acid may mimic l-fucose, a natural-occurring monosaccharide involved in many molecular recognition events. Final compounds prepared from l-serine bear S configurations on the C5 position. The synthesis involved a stereoselective cyclopropanation reaction of an α,β-unsatur
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Xinhua Qian, Francisco Morís-Varas, and Chi-Huey Wong. "Synthesis of C2-symmetrical polyhydroxyazepanes as inhibitors of glycosidases." Bioorganic & Medicinal Chemistry Letters 6, no. 10 (1996): 1117–22. http://dx.doi.org/10.1016/0960-894x(96)00183-7.

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Serbian, Immo, Erik Prell, Claudia Fischer, Hans-Peter Deigner та René Csuk. "n-Propyl 6-amino-2,6-dideoxy-2,2-difluoro-β-d-glucopyranoside is a good inhibitor for the β-galactosidase from E. coli". Medicinal Chemistry Research 30, № 5 (2021): 1099–107. http://dx.doi.org/10.1007/s00044-021-02715-8.

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AbstractA convenient route has been developed for the synthesis of novel 6-amino-2,2-(or 3,3-difluoro)-2-(or 3),6-dideoxy-hexopyranoses. Biological screening showed these compounds as good inhibitors for several glycosidases. Especially n-propyl 6-amino-2,6-dideoxy-2,2-difluoro-β-d-glucopyranoside (8) was an excellent competitive inhibitor for the β-galactosidase from E. coli holding a Ki of 0.50 μM.
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LE MERRER, Y., M. FUZIER, I. DOSBAA, M. J. FOGLIETTI, and J. C. DEPEZAY. "ChemInform Abstract: Synthesis of Thiosugars as Weak Inhibitors of Glycosidases." ChemInform 29, no. 13 (2010): no. http://dx.doi.org/10.1002/chin.199813179.

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Samoshin, Andrey V., Irina A. Dotsenko, Nataliya M. Samoshina, Andreas H. Franz та Vyacheslav V. Samoshin. "Thio-β-D-glucosides: Synthesis and Evaluation as Glycosidase Inhibitors and Activators". International Journal of Carbohydrate Chemistry 2014 (21 серпня 2014): 1–8. http://dx.doi.org/10.1155/2014/941059.

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Structurally simple 1-thio-β-D-glucopyranosides were synthesized and tested as potential inhibitors toward several fungal glycosidases from Aspergillus oryzae and Penicillium canescens. Significant selective inhibition was observed for α- and β-glucosidases, while a weak to moderate activation for α- and β-galactosidases.
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Meloncelli, Peter J., Tracey M. Gloster, Victoria A. Money та ін. "D-Glucosylated Derivatives of Isofagomine and Noeuromycin and Their Potential as Inhibitors of β-Glycoside Hydrolases". Australian Journal of Chemistry 60, № 8 (2007): 549. http://dx.doi.org/10.1071/ch07188.

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While isofagomine and noeuromycin have previously been demonstrated to be effective inhibitors of a range of exo-acting glycosidases, they are usually only very weak inhibitors of endo-glycosidases. However, the disaccharide-like 3- and 4-O-β-d-glucopyranosylisofagomines have proven to be strong inhibitors of these endo-acting enzymes that utilize multiple sub-sites. In an attempt to emulate these successes, we have prepared 3- and 4-O-β-d-glucopyranosylnoeuromycin, the former by a selective glycosylation (at O2) of benzyl 4-C-cyano-4-deoxy-α-d-arabinoside (also leading to another synthesis of
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QIAN, X., F. MORIS-VARAS, and C. H. WONG. "ChemInform Abstract: Synthesis of C2-Symmetrical Polyhydroxyazepanes as Inhibitors of Glycosidases." ChemInform 27, no. 37 (2010): no. http://dx.doi.org/10.1002/chin.199637284.

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Dissertations / Theses on the topic "Glycosidases – Inhibitors – Synthesis"

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Caron, Gaétan. "Synthesis of cyclitol-based glucosidase inhibitors." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/27852.

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The first conduritol aziridine (1,2-dideoxy-1,2-epimino-myo-inositol, 1) was synthesized in seven steps from myo-inositol (2) and inhibits pABG5 β-glucosidase and yeast ⍺-glucosidase irreversibly. 1,2-0-Cyclohexylidene-myo-inositol (3) was obtained by reaction of 2 with cyclohexanone. Benzylation of 3 followed by hydrolysis of the ketal gave l,4,5,6-tetra-0-benzyl-myo-inositol (5). The two free hydroxyl groups in 5 were methanesulfonylated and the axial mesyl group in l,4,5,6-tetra-0-benzyl-2,3-di-0-methanesulfonyl-myo-inositol (12) was selectively displaced by an azido group. The resulting 1-
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Meloncelli, Peter J. "The synthesis of several azasugars, glycosylated azasugars and disaccharides of biological interest." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0052.

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[Truncated abstract] The development of several carbohydrate-based pharmaceuticals has stimulated an increased interest in the field of carbohydrate chemistry. The discovery of Acarbose and invention of Miglitol, treatments for type II diabetes, as well as the influenza treatments, Relenza and Tamiflu, have been largely responsible for this increased interest. These treatments operate by the inhibition of glycoside hydrolases, a group of enzymes important in a variety of biological processes. This thesis involves the study of a group of glycoside hydrolase inhibitors known as azasugars, which
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Miglioli, Francesca. "Synthesis and biological evaluation of bicyclic iminosugar derivatives as inhibitors of glycosidases." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/16676/.

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During this work, five pyrrolizidine derivatives and one isoxazolidine derivative have been synthetized in order to evaluate their biological activities towards glycosidases, related to their configurations and type of bridge functionalities between the bicyclic iminosugar moiety and the aromatic part of the molecules. The final pyrrolizidine derivatives have been synthetized through click reactions (urea forming reaction, thiourea forming reaction and CuAAC reaction) performed on a common amino-pyrrolizidine precursor. The final isoxazolidine derivative has been synthetized through a CuAAC re
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Scaffidi, Adrian. "Synthetic endeavours in carbohydrates." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0114.

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The overwhelming occurrence and structural diversity of carbohydrates in Nature indicate their importance in a range of fundamental life processes. Indeed, it is this diversity that has lead to the two equally diverse groups of carbohydrate-processing enzymes, namely the glycoside hydrolases and glycosyl transferases. Thus, understanding the role of both carbohydrates and their processing enzymes in biological systems has attracted significant attention. This thesis, firstly, describes endeavours towards the synthesis of an inositol ?- amino acid, along with a series of sugar α-substituted car
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Heightman, Tom Daniel. "O-glycosidases under scrutiny: synthesis of inhibitors and structural probes : and Synthesis of a potential DNA-binding pseudotetrasaccharide /." Zürich, 1998. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=12696.

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Carpenter, Neil M. "Studies on glycosidase inhibitors." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236101.

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Namgoong, Sung Keon. "The synthesis of glycosidase inhibitors." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236199.

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Ong, Quyen Binh. "An enantioselective synthesis of glycosidase inhibitors." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314209.

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Dedola, Simone. "'Click chemistry' to synthesise potential glycosidase inhibitors." Thesis, University of East Anglia, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502211.

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In this study, "click chemistry" was used to assemble a collection of potential glycosidase inhibitors. Using different "click chemistry" conditions, 21 α-D- and β-D glucopyranosyl triazoles were synthesised and assayed as inhibitors of sweet almond β-glucosidase and yeast α-glucosidase. A set of moderately effective glycosidase inhibitors was identified. In the course of this work significant differences in the reactivity of the α- and β-glucopyranosyl azides under CuAAC conditions was noted. This matter was investigated by X-ray crystallography and, in keeping with the anomeric effect, point
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Nkansah, Peter Appah. "Syntheses of pyridylglucoconjugates as potential glycosidase inhibitors." Thesis, University of East Anglia, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368182.

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Book chapters on the topic "Glycosidases – Inhibitors – Synthesis"

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de Raadt, Anna, Christian W. Ekhart, Michael Ebner, and Arnold E. Stütz. "Chemical and chemo-enzymatic approaches to glycosidase inhibitors with basic nitrogen in the sugar ring." In Glycoscience Synthesis of Substrate Analogs and Mimetics. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/bfb0119256.

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Nishimura, Yoshio. "Glycosidase and Glycosyltransferase Inhibitors." In Stereoselective Synthesis. Elsevier, 1992. http://dx.doi.org/10.1016/b978-0-444-89558-5.50038-9.

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Bols, M., Ó. López, and F. Ortega-Caballero. "Glycosidase Inhibitors: Structure, Activity, Synthesis, and Medical Relevance." In Comprehensive Glycoscience. Elsevier, 2007. http://dx.doi.org/10.1016/b978-044451967-2/00100-8.

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Nishimura, Yoshio. "Stereoselective synthesis and transformation of siastatin B, A novel glycosidase inhibitor, directed toward new drugs for viral infection and tumor metastasis." In Stereoselective Synthesis (Part J). Elsevier, 1995. http://dx.doi.org/10.1016/s1572-5995(06)80053-0.

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Conference papers on the topic "Glycosidases – Inhibitors – Synthesis"

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Malle, Birgitte M., Morten B. Norgaard, and Inge Lundt. "SYNTHESIS OF DEOXYIMINOURONIC ACIDS - EASY ACCESS TO GLYCURONIDASE AND GLYCOSIDASE INHIBITORS." In XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.449.

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Ghavami, Ahmad, Blair D. Johnston, Morten T. Jensen, Birte Svenson, and Morten B. Mario Pinto. "SYNTHESIS OF A NEW CLASS OF GLYCOSIDASE INHIBITORS: SALACINOL, ITS STEREOISOMERS, AND NITROGEN AND SELENIUM ANALOGUES, AND THEIR EVALUATION AS GLYCOSIDASE INHIBITORS." In XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.510.

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Sakaba, Ai, Katsuhiko Suzuki, and Masanori Yamaura. "REACTIONS OF CYCLIC NITRONES AND NUCLEOPHILES: A STRATEGY FOR THE SYNTHESIS OF PYRROLIDINES GLYCOSIDASE INHIBITORS." In XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.633.

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Aghajari, Nushin, Michel Roth, and Richard Haser. "EVIDENCE OF OLIGOSACCHARIDE SYNTHESIS BY CRYSTALS OF A COLD-ACTIVE ALPHA-AMYLASE: CHARACTERIZATION OF A NEW ALPHA-GLYCOSIDASE INHIBITOR." In XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.588.

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