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Journal articles on the topic 'Glycosides – therapeutic use'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Groult, Hugo, Isabel García-Álvarez, Lorenzo Romero-Ramírez, et al. "Micellar Iron Oxide Nanoparticles Coated with Anti-Tumor Glycosides." Nanomaterials 8, no. 8 (2018): 567. http://dx.doi.org/10.3390/nano8080567.

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The synthesis procedure of nanoparticles based on thermal degradation produces organic solvent dispersible iron oxide nanoparticles (OA-IONP) with oleic acid coating and unique physicochemical properties of the core. Some glycosides with hydrophilic sugar moieties bound to oleyl hydrophobic chains have antimitotic activity on cancer cells but reduced in vivo applications because of the intrinsic low solubility in physiological media, and are prone to enzymatic hydrolysis. In this manuscript, we have synthetized and characterized OA-IONP-based micelles encapsulated within amphiphilic bioactive

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Kochetov, Aleksey Aleksandrovich, and Nadezhda Georgiyevna Sinyavina. "STEVIA (STEVIA REBAUDIANA BERTONI): BIOCHEMICAL COMPOSITION, THERAPEUTIC PROPERTIES AND USE IN THE FOOD INDUSTRY (REVIEW)." chemistry of plant raw material, no. 2 (June 10, 2021): 5–27. http://dx.doi.org/10.14258/jcprm.2021027931.

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The review presents the current state of the science for stevia (Stevia rebaudiana Bertony), its biochemical composition, therapeutic properties and using in the food industry. Interest in this plant, a source of natural low-calorie sweeteners, is associated with increased consumption of dietary sweeteners, caused by an increase in the number of patients with diabetes, metabolic syndrome, and with many negative effects from the use of synthetic sweeteners. Diterpene glycosides from stevia have a high sweetness (50-350 times sweeter than sucrose), low calorie content, safe for human health. In

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Innocent Izuchukwu Ujah, Chukwunonso Anthony Nsude, Onuabuchi Nnenna Ani, Uchenna Blessing Alozieuwa, Innocent Oluwaseun Okpako, and Amos Ejiofor Okwor. "Phytochemicals of neem plant (Azadirachta indica) explains its use in traditional medicine and pest control." GSC Biological and Pharmaceutical Sciences 14, no. 2 (2021): 165–71. http://dx.doi.org/10.30574/gscbps.2021.14.2.0394.

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Neem Azadirachta indica is a useful traditional medicinal plant growing in Nigeria, India, and America. The phytochemicals and the biopesticidal components present were ascertained. The results showed that saponins, steroids and terpenes were mostly present, while tannins and glycosides were moderately present, and alkaloids, flavonoids, phenols and oxalic acid were least present. The presence of these phytochemical could account for the therapeutic uses of neem.

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Luwańska, Aleksandra, Aleksandra Perz, Grażyna Mańkowska, and Karolina Wielgus. "Application of in vitro stevia (Stevia rebaudiana Bertoni) cultures in obtaining steviol glycoside rich material." Herba Polonica 61, no. 1 (2015): 50–63. http://dx.doi.org/10.1515/hepo-2015-0010.

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Summary Stevia is a plant attracting attention due to its capability to synthesize a group of chemical compounds with sweet taste, i.e. steviol glycosides. Steviol glycosides are successfully applied as a natural sweetener, and some of them have also therapeutic properties. This paper presents available information on the use of stevia plant tissue cultures with the focus on their potential application in food industry. Detailed analysis was done concerning the research employing in vitro culture techniques and the use of them in biosynthesis of secondary metabolites of high importance for the

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Dauda Muhammed, Yetunde H. Adebiyi, Bernard O. Odey, et al. "Dennettia tripetala (Pepper Fruit), a review of its ethno-medicinal use, phyto-constituents, and biological properties." GSC Advanced Research and Reviews 6, no. 3 (2021): 035–43. http://dx.doi.org/10.30574/gscarr.2021.6.3.0024.

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There has been tremendous growth in field of herbal medicine as therapeutic agents. Dennettia tripetala, is known to possess ethnomedicinal properties and has been used for centuries in the Ayurvedic system of medicine for the treatments of various diseases. The present review provides detailed description on the distribution, ethno-medicinal use, phyto-constituents, and biological properties of the plant that justifies its use as a potential therapeutic agent in management of different diseases. The phyto chemical composition of Dennettia tripetala include alkaloids, tannins, saponins, flavon

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Baek, Su Cheol, Sang Ah Yi, Bum Soo Lee, et al. "Anti-Adipogenic Polyacetylene Glycosides from the Florets of Safflower (Carthamus tinctorius)." Biomedicines 9, no. 1 (2021): 91. http://dx.doi.org/10.3390/biomedicines9010091.

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Safflower (Carthamus tinctorius) is an annual herb belonging to the Compositae family; it has a history of use as a food colorant, dye, and medicine in oriental countries. LC-MS-UV-based chemical analysis of extract of the florets of C. tinctorius led to the isolation of two new C10-polyacetylene glycosides, (8Z)-decaene-4,6-diyne-1,10-diol-1-O-β-d-glucopyranoside (1) and (8S)-deca-4,6-diyne-1,8-diol-1-O-β-d-glucopyranoside (2), together with five known analogs (3–7). The structures of the new compounds were determined by using 1D and 2D NMR spectroscopic data and HR-MS data, as well as chemic

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Cole, Patricia L., and Thomas W. Smith. "Use of Digoxin-Specific Fab Fragments in the Treatment of Digitalis Intoxication." Drug Intelligence & Clinical Pharmacy 20, no. 4 (1986): 267–70. http://dx.doi.org/10.1177/106002808602000403.

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The narrow margin between therapeutic and toxic effects of digitalis glycosides renders patients taking these drugs particularly susceptible to serious consequences of accidental or deliberate overdosage, including life-threatening arrhythmias. Until recently, the treatment of digitalis intoxication has been largely supportive. In the past decade, however, digoxin-specific antibodies have been developed and have proven to be effective in rapidly reversing the electrophysiologic and metabolic manifestations of digitalis intoxication, both in vitro and in vivo. Enzymatic cleavage of the intact a

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Vemuri, R., S. Longoni, and K. D. Philipson. "Ouabain treatment of cardiac cells induces enhanced Na+-Ca2+ exchange activity." American Journal of Physiology-Cell Physiology 256, no. 6 (1989): C1273—C1276. http://dx.doi.org/10.1152/ajpcell.1989.256.6.c1273.

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Inhibition of the cardiac Na+-K+-ATPase with cardiac glycosides causes a rise in internal Na+ and a subsequent increase in cellular Ca2+ due to the sarcolemmal Na+-Ca2+ exchange mechanism. We investigated the adaptation of cultured cardiac cells to prolonged elevation of internal Ca2+ after exposure to ouabain. Cultured neonatal rat heart cells were treated with 100 microM ouabain for 4-48 h. This ouabain concentration inhibited Na+-K+-ATPase activity by approximately 45% and caused modest cellular Ca2+ loading. We found that cells adapted to ouabain treatment by increasing the amount of sarco

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Shi, Ze-Yu, Jin-Zhang Zeng, and Alice Sze Tsai Wong. "Chemical Structures and Pharmacological Profiles of Ginseng Saponins." Molecules 24, no. 13 (2019): 2443. http://dx.doi.org/10.3390/molecules24132443.

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Ginseng is a group of cosmopolitan plants with more than a dozen species belonging to the genus Panax in the family Araliaceae that has a long history of use in traditional Chinese medicine (TCM). Among the bioactive constituents extracted from ginseng, ginseng saponins are a group of natural steroid glycosides and triterpene saponins found exclusively throughout the plant. Studies have shown that these ginseng saponins play a significant role in exerting multiple therapeutic effects. This review covers their chemical structure and classification, as well as their pharmacological activities, i

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N, Mishra D., Gomare K. S, and Sheelwant S. V. "GC-MS Analysis and Phytochemical Screening of Indigofera tinctoria (Linn.) Leaf Extract Characterizing its Medicinal Use." International Journal of Ayurvedic Medicine 11, no. 2 (2020): 289–99. http://dx.doi.org/10.47552/ijam.v11i2.1540.

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Indigofera tinctoria (Linn.), a perennial shrub belongs to the family Fabaceae (Leguminosae) is well known in Indian system of medicines for its traditional uses. The present study was carried to find out the possible bioactive components in the leaves of this plant in ethanol extract by Gas Chromatography-Mass Spectrometry (GC-MS) analysis and the therapeutic uses of each compound as per PASS and other database. The mass spectra of the extract found compounds that were matched with the National Institute of Standards and Technology (NIST version 5.7.1) library database. The GC-MS study observ

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Nahrin, Afsana, Md Junaid, Syeda Samira Afrose, et al. "A Review of Saurauia roxburghii Wall. (Actinidiacaea) as a Traditional Medicinal Plant, Its Phytochemical Study and Therapeutic Potential." Mini-Reviews in Medicinal Chemistry 20, no. 19 (2020): 2036–51. http://dx.doi.org/10.2174/1389557520666200709175138.

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Saurauia roxburghii Wall. is an interesting plant, found growing chiefly along the eastern and south-eastern countries of Asia. The various ethnic groups of these regions use the plant as a medication for relieving a wide spectrum of diseases and conditions, including indigestion, boils, fever, gout, piles, eczema, asthma, ulcers, bronchitis, epilepsy, and hepatitis B. This review aims to appraise the vernacular information, botanical characterization, geographical distribution, traditional uses, phytochemistry, and pharmacological activities of S. roxburghii as well as to conduct a critical a

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C., Ramya, Vishnu AS, and Nasila K. "A Review: Cyanthillium cinereum (L) H. Rob." International Journal of Research and Review 8, no. 9 (2021): 99–101. http://dx.doi.org/10.52403/ijrr.20210914.

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Cyanthillium cinereum (L) H. Rob (family Asteraceae) is also known as Poovamkurunnila in Malayalam. It is commonly found as a weed throughout in India. Cyanthillium cinereum is an annual herb with hairy stem, up to 12-75 cm height. The leaves are simple, alternate, ovate-elliptic or acute, irregularly dentate or crenate-serrate and hairy. Cyanthillium cinereum is an annual herb, contains various phytochemicals like cardiac glycosides, phenols, flavonoids, steroids, tannins, saponins and phlobatannins etc. Due to the presence of these phytochemicals Cyanthillium cinereum exhibits various activi

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Vaidya, Hitesh B., Abeer A. Ahmed, Ramesh K. Goyal, and Sukhinder K. Cheema. "Glycogen Phosphorylase-a is a Common Target for Anti-Diabetic Effect of Iridoid and Secoiridoid Glycosides." Journal of Pharmacy & Pharmaceutical Sciences 16, no. 4 (2013): 530. http://dx.doi.org/10.18433/j3fs4f.

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Purpose. Diabetes mellitus is characterized by hyperglycemia resulting from defects in insulin secretion, action or both. The use of medicinal plants for the treatment of diabetes mellitus dates back from the Ebers papyrus of about 1550 B.C. One of the major problems with herbal drugs is that the active ingredients are not well defined. It is important to know the active components and their molecular interactions which will help to analyze their therapeutic efficacy and also to standardize the product. There are a number of medicinal plants known for their anti-diabetic effect that possess si

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Thakur, Shifali, Hemlata Kaurav, and Gitika Chaudhary. "A Review on Woodfordia fruticosa Kurz (Dhatki): Ayurvedic, Folk and Modern Uses." Journal of Drug Delivery and Therapeutics 11, no. 3 (2021): 126–31. http://dx.doi.org/10.22270/jddt.v11i3.4839.

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Woodfordia fruticosa kurz is an herbal plant that belongs to the family Lythraceae. This plant is widely distributed throughout the tropical and subtropical regions of India, Sri Lanka, China, Malaysia, Indonesia, Japan and Pakistan. The plant possesses a long history of medicinal use. The flowers of Woodfordia fruticosa are recorded to possess potent therapeutic values. The various phytochemicals isolated from this plant are tannins, flavonoids, anthraquinone, glycosides and polyphenols. The extract of flowers and leaves are associated with useful therapeutic activities. These phytochemical c

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Ann Maria Alex and Suresh Joghee. "Phytochemistry and Therapeutic potential of Bauhinia racemosa Lam. - A Concise Review." International Journal of Research in Pharmaceutical Sciences 11, no. 1 (2020): 1045–50. http://dx.doi.org/10.26452/ijrps.v11i1.1934.

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Nature has consistently been a healing source of ailments for living organisms from the millennium era. Even though nature comprises of diverse animals and plants of immense therapeutic potential, plants due to its easy accessibility play a predominant lead in this perspective. In this scenario, herbal medicine dawned on the treatment of various diseases and the suffering of mankind. Each plant has to be scientifically explored to validate its therapeutic potential. Bauhinia racemosa Lam. is a tree broadly distributed in the tropical climate regions of the earth. Bauhinia species are generally

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Lin, Sheng-Chieh, Li-Shian Shi, and Yi-Ling Ye. "Advanced Molecular Knowledge of Therapeutic Drugs and Natural Products Focusing on Inflammatory Cytokines in Asthma." Cells 8, no. 7 (2019): 685. http://dx.doi.org/10.3390/cells8070685.

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Asthma is a common respiratory disease worldwide. Cytokines play a crucial role in the immune system and the inflammatory response to asthma. Abnormal cytokine expression may lead to the development of asthma, which may contribute to pathologies of this disease. As cytokines exhibit pleiotropy and redundancy characteristics, we summarized them according to their biologic activity in asthma development. We classified cytokines in three stages as follows: Group 1 cytokines for the epithelial environment stage, Group 2 cytokines for the Th2 polarization stage, and Group 3 cytokines for the tissue

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Ghogar, Anisa, Kanitta Jiraungkoorskul, and Wannee Jiraungkoorskul. "Paper Flower, Bougainvillea spectabilis: Update Properties of Traditional Medicinal Plant." Journal of Natural Remedies 16, no. 3 (2016): 82. http://dx.doi.org/10.18311/jnr/2016/5703.

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Paper Flower, <em>Bougainvillea spectabilis</em> is reported to have medicinal values including antiancer, antidiabtic, anti-heptotoxic, anti-inflammtory, antiyperlipidemic, antimicrobial, antioxidant and antiulcer properties. The phytoconstituents such as alkaloids, flvonoids, glycosides, phenolics, phlobotannins, quinones, saponins, tannins and terpenoids were reported as the basis of therapeutic properties. The other important constituents which contribute to the remedial properties are bougainvinones, pinitol, quercetagetin, quercetin and terpinolene. Published information on t

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Ghosh, Sourav, Arvind Kumar, Neetu Sachan, and Phool Chandra. "Re-exploring an Epicentre Spice with Immense Therapeutic Potentials: Black Pepper (Piper nigrum)." Current Nutrition & Food Science 16, no. 9 (2020): 1326–37. http://dx.doi.org/10.2174/1573401316666200316120944.

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Background: Spices are mostly used as additives in food regularly to enhance the taste and flavour. From ancient times, the plant of Piperaceae family contributes a large variety of species to the spices section, from which Piper nigrum is one of the widely used spices worldwide in culinary and as a medicinal agent. Piper nigrum is known as the king of spice due to its impactful constituent ‘piperine’. Objective: To report a comprehensive view on the botanical description, traditional and culinary use, phytochemistry, pharmacological activity, and toxicology of P. nigrum. Methods: Literature s

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Rai, Kriti, Nirmala Gupta, Lakshya Dharamdasani, Pallavi Nair, and Prerna Bodhankar. "Bacopa Monnieri: A Wonder Drug Changing Fortune of People." International Journal of Applied Sciences and Biotechnology 5, no. 2 (2017): 127–32. http://dx.doi.org/10.3126/ijasbt.v5i2.16952.

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In recent times, the use of herbal products has increased enormously across the globe. Numerous natural products such as those isolated from plants have been evaluated as therapeutics for the treatment of variety of diseases. Bacopa monnieri also referred to as water hyssop and “Brahmi,” has been used in the Ayurvedic system of medicine since time immemorial. It belongs to the family Scrophulariaceae and is an annual creeping plant found in wet, damp, and marshy areas. Phytochemical analysis of BM extracts revealed the presence of various biochemical compounds such as alkaloids, bacosides, fla

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Maryam, Amara, Tahir Mehmood, Qiulong Yan, Yongming Li, Muhammad Khan, and Tonghui Ma. "Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells." Oxidative Medicine and Cellular Longevity 2018 (2018): 1–17. http://dx.doi.org/10.1155/2018/3853409.

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Cardiac glycosides are natural compounds used for the treatment of cardiovascular disorders. Although originally prescribed for cardiovascular diseases, more recently, they have been rediscovered for their potential use in the treatment of cancer. Proscillaridin A (PSD-A), a cardiac glycoside component of Urginea maritima, has been reported to exhibit anticancer activity. However, the cellular targets and anticancer mechanism of PSD-A in various cancers including lung cancer remain largely unexplored. In the present study, we found that PSD-A inhibits growth and induces apoptosis in A549 lung

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Laily, Ainun Nikmati, and Ahmad Nuruddin Khoiri. "IDENTIFIKASI SENYAWA ANTIDIABETES SECARA in Silico PADA Carica pubescens Lenne & K. Koch." el–Hayah 5, no. 4 (2016): 135. http://dx.doi.org/10.18860/elha.v5i4.3469.

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<em>Carica pubescens Lenne &amp; K. Koch is one of the typical highland crops in Indonesia. This plant can be found in the region of Cangar and Bromo in East Java, as well as the Dieng Plateau, Central Java Wonosobo-Banjarnegara. Morphological, chemical content, and analysis of protein banding pattern of the Carica pubescens has been done, but more about the use of active compounds for pharmaceutical raw materials, in Diabetes Mellitus type 2 have not been studied. One therapeutic approach to lowering blood sugar levels posprandial is to slow down or inhibit the absorption of glucose

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Muni Raja Lakshmi, K., M. Kiran, and K. Sai Prasanna. "A Review on Natural Plants for Phytochemical Constituents and Pharmacological Activities." Journal of Drug Delivery and Therapeutics 11, no. 2 (2021): 232–36. http://dx.doi.org/10.22270/jddt.v11i2.4593.

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The present review aims for the study of phytoconstituents and pharmacological activities of some natural plants. The traditional medicinal plants have been found to acquire therapeutic activities significantly antimicrobial, anti-inflammatory antibacterial, anti-fungal, antioxidant properties etc. The plant-derived constituents are majorly for the aliments of used skin disease diabetes, bronchitis, asthma, arthritis, dry cough, ulcer and fever. The antimicrobial activity of the following plants like Justicia adathoda, Lantana Camara, Acacia leucophloea, Holoptelea integrifolia, Calotropis Pro

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Kim, Sang-Eun, Koichiro Kawaguchi, Hiroko Hayashi, Katsuhiro Furusho, and Mitsuo Maruyama. "Remission Effects of Dietary Soybean Isoflavones on DSS-Induced Murine Colitis and an LPS-Activated Macrophage Cell Line." Nutrients 11, no. 8 (2019): 1746. http://dx.doi.org/10.3390/nu11081746.

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Inflammatory bowel diseases (IBDs), including ulcerative colitis and Crohn’s disease, are chronic disorders of the gastrointestinal tract, although the exact causes of IBD remain unknown. Present treatments for IBDs have poor tolerability and insufficient therapeutic efficacy, thus, alternative therapeutic approaches are required. Soybean-derived isoflavones have multiple bioactivities such as anti-inflammation. However, the low water solubility of soybean isoflavones limits their bioavailability and practical use. Therefore, in order to study the preventive effects of water-soluble soybean is

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Wang, Yuxiao, Zhenzhen Xu, Yuqi Huang, et al. "Extraction, Purification, and Hydrolysis Behavior of Apigenin-7-O-Glucoside from Chrysanthemum Morifolium Tea." Molecules 23, no. 11 (2018): 2933. http://dx.doi.org/10.3390/molecules23112933.

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Apigenin-7-O-glucoside is an active phenolic compound in Asteraceae flowers and possesses remarkable therapeutic applications. However, its high price and low abundance in plants limit its use, meanwhile it would hydrolyze in the purification process. In this study, apigenin-7-O-glucoside extracted with ultrasound and purified with preparative HPLC from Chrysanthemum morifolium ‘Huangju’ was investigated, as well as its hydrolysis behavior and bioactivities. The optimized extraction conditions were: solid/liquid ratio: 1:20, extraction time: 35 min, temperature: 50 °C, and ultrasound power: 35

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Sahay, Rakesh, and V. Nagesh. "Type 1 diabetes and fasting during Ramzan." Journal of Social Health and Diabetes 04, no. 01 (2016): 011–16. http://dx.doi.org/10.4103/2321-0656.176571.

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AbstractFasting is one of the five pillars of Islam, and consequently, even the Muslims with diabetes prefer to fast fast during Ramadan, irrespective of the healthcare implications. However, this fast can be very difficult to manage in patients of Type 1 diabetes (T1DM), who are on insulin therapy. Risks of diabetic ketoacidosis, severe hypoglycaemia, hyperglycemia, dehydration and thrombotic episodes are increased. Lack of proper pre-fast assessment, management and diabetes education have been stumbling blocks in facilitating Ramadan fasting in type 1 diabetes patients. Recent developments l

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Litonjua, M. Regina, Stephanie Penton, Craig Robinson, and G. Patrick Daubert. "Digoxin: The Monarch of Cardiac Toxicities." Journal of Pharmacy Practice 18, no. 3 (2005): 157–68. http://dx.doi.org/10.1177/0897190005276751.

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The cardiac steroids (or glycosides) are a heterogeneous group of compounds that have been well recognized for both their clinical benefit and inherent toxicity. This review will primarily focus on digoxin because of its widespread clinical use, although the other cardiac steroids will be discussed in less detail. The cardiac steroids have a narrow therapeutic index and remain a significant source of toxicity, with nearly 5000 human exposures reported to the American Association of Poison Control Centers in 2002. Digoxin reversibly binds to the α subunit of the Na+ -K+ ATPase pump and complete

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Marina Silalahi. "Utilization and bioactivity of Blumea balsaminifera (L.) DC." GSC Biological and Pharmaceutical Sciences 16, no. 2 (2021): 224–28. http://dx.doi.org/10.30574/gscbps.2021.16.2.0234.

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Sembung or Blumea balsaminifera a species belonging of Asteraceae has been long used as a traditional medicine. The using of plants as traditional medicine, directly or indirectly related to their bioactive compounds. The writing of this article is based on literature review of the published online and offline such as journals, books, and other research to obtained comprehensive information of the benefits, secondary metabolites, bioactivity, and prospects for the use of B. balsaminifera. The ethnobotany of B. balsaminifera uses as an ingredient of loloh (Bali Aga ethnic health drink), treat o

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Hua, Shiyao, Yiwei Zhang, Jiayue Liu, et al. "Ethnomedicine, Phytochemistry and Pharmacology of Smilax glabra: An Important Traditional Chinese Medicine." American Journal of Chinese Medicine 46, no. 02 (2018): 261–97. http://dx.doi.org/10.1142/s0192415x18500143.

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Smilax glabra (SG) Roxb., a well-known traditional Chinese medicine, has been extensively used worldwide for its marked pharmacological activities for treating syphilitic poisoned sores, limb hypertonicity, morbid leucorrhea, eczema pruritus, strangury due to heat, carbuncle toxin, and many other human ailments. Approximately 200 chemical compounds have been isolated from SG Roxb., and the major components have been determined to be flavonoids and flavonoid glycosides, phenolic acids, and steroids. Among these active compounds, the effects of astilbin, which is used as a quality control marker

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Shrivastava, Rachna. "Extraction, Qualitative and Quantitative Determination of Secondary Metabolites of Coccinia Indica Fruits." Journal of Drug Delivery and Therapeutics 9, no. 1-s (2019): 256–59. http://dx.doi.org/10.22270/jddt.v9i1-s.2341.

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In the last few years, there has been an exponential growth in the field of herbal medicine and gaining popularity both in developing and developed countries because of their natural origin and less side effects. Medicinal plants continue to be an important therapeutic aid for alleviating ailments of humankind. Coccinia Indica (C. indica, cucurbitaceae) is found in warmer and humid part of India. It is also known as Kundru, Bimbi, Lindora. The various extracts of fruit, root juice & leaves of the plant have been reported to be anti-diabetic, dysentery, vomiting, mouth ulcers and bronchitis

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Gopi, Anju, and Manju Jisho. "Evaluation of anti-lipoxygenase activity of Cassia fistula linn leaves using in vitro methods." International Journal of Basic & Clinical Pharmacology 7, no. 9 (2018): 1678. http://dx.doi.org/10.18203/2319-2003.ijbcp20183462.

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Background: Numerous plants are claimed to possess anti-inflammatory phytoconstituents in folk medicine, however, one among them is Cassia fistula linn leaves. The tree is 6-9 m high with straight trunk and smooth bark. It is pale green when young and gets rough and dark when old. The leaves are 23-30cm long and have got 4-8 pairs of oblong leaflets. Due to lack of specific scientific reports regarding its use for its anti-lipoxygenase property, this particular plant was selected for this particular study with the aim to bring scientific evidence for its therapeutic use.Methods: The anti-lipox

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Yang, You-Lan, Hsin-Te Hsu, Kuo-Hsien Wang, Chao-Sian Wang, Chien-Ming Chen, and Wun-Chang Ko. "Hesperidin-3′-O-Methylether Is More Potent than Hesperidin in Phosphodiesterase Inhibition and Suppression of Ovalbumin-Induced Airway Hyperresponsiveness." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–12. http://dx.doi.org/10.1155/2012/908562.

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Hesperidin is present in the traditional Chinese medicine, “Chen Pi,” and recently was reported to have anti-inflammatory effects. Therefore, we were interested in comparing the effects of hesperidin and hesperidin-3′-O-methylether on phosphodiesterase inhibition and airway hyperresponsiveness (AHR) in a murine model of asthma. In the present results, hesperidin-3′-O-methylether, but not hesperidin, at 30 μmol/kg (p.o.) significantly attenuated the enhanced pause (Penh) value, suppressed the increases in numbers of total inflammatory cells, macrophages, lymphocytes, neutrophils, and eosinophil

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Michel, Piotr, Sebastian Granica, Anna Magiera, et al. "Salicylate and Procyanidin-Rich Stem Extracts of Gaultheria procumbens L. Inhibit Pro-Inflammatory Enzymes and Suppress Pro-Inflammatory and Pro-Oxidant Functions of Human Neutrophils Ex Vivo." International Journal of Molecular Sciences 20, no. 7 (2019): 1753. http://dx.doi.org/10.3390/ijms20071753.

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Salicylate-rich plants are an attractive alternative to synthetic anti-inflammatory drugs due to a better safety profile and the advantage of complementary anti-inflammatory and antioxidant effects of the co-occurring non-salicylate phytochemicals. Here, the phytochemical value and biological effects in vitro and ex vivo of the stems of one of such plants, Gaultheria procumbens L., were evaluated. The best extrahent for effective recovery of the active stem molecules was established in comparative studies of five extracts. The UHPLC-PDA-ESI-MS3, HPLC-PDA, and UV-photometric assays revealed tha

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Volkov, V. A., M. V. Voronkov, V. M. Misin, E. S. Fedorova, I. A. Rodin, and A. N. Stavrianidi. "Chemical composition, antioxidant activity, standardization and kinetics of production of water-propylene glycol extracts of medicinal plants." Industrial laboratory. Diagnostics of materials 86, no. 8 (2020): 12–22. http://dx.doi.org/10.26896/1028-6861-2020-86-8-12-22.

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Water-propylene glycol extracts of medicinal plants are widely used as active components in therapeutic and cosmetic products for external use. However, sparse data on the extracting efficiency of water-propylene glycol mixtures and chemical composition of water-propylene glycol extracts of plant raw materials are available in the scientific literature. Usually the manufacturer documentation also provides information about characteristics of the products that are not related to their biological activity. The results of HPLC/MS/MS study of Matricaria chamomilla L. flowers have shown that water-

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Lin, Jianqing, Jean H. Hoffman-Censits, Danielle Duffy, et al. "A pilot phase II study of digoxin in patients with recurrent prostate cancer as evident by a rising PSA." Journal of Clinical Oncology 31, no. 15_suppl (2013): 5061. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.5061.

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5061 Background: Hypoxia-inducible factor 1α (HIF-1α) is a novel cancer drug target and inhibitors of hypoxia-response pathway are being developed. Digoxin and other cardiac glycosides were found to inhibit prostate cancer (PCa) growth via the inhibition of HIF-1α synthesis in mouse model. Epidemiologic data showed that use of digoxin in men was associated with a significant lower risk of development of PCa. We hypothesized that therapeutic dose of digoxin could inhibit human PCa growth and disease progression. Methods: Open label, non-placebo pilot study. Non-metastatic, biochemically relapse

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Diop, Amadou, Serigne Omar Sarr, Awa Boubou Sall, Ousmane Niass, Bara Ndiaye, and Yerim Mbagnick Diop. "Nutritional and antioxidant potential of seeds from two Cucurbitaceae species from Senegal." European Journal of Chemistry 11, no. 4 (2020): 364–69. http://dx.doi.org/10.5155/eurjchem.11.4.364-369.2046.

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Cucurbits are largely grown in tropical and subtropical areas for nutritional and medicinal purposes. In Senegal, two species, watermelon (Citrullus lanatus) and pumpkin (Cucurbita pepo), are cultivated and their use include consumption of flesh or the whole fruit. In general, people don’t give importance to seeds which can have nutritional properties of great interest. Hence, the relevance of this study whose objective is to assess the nutritional and therapeutic properties of seeds. For that purpose, the seeds of watermelon and pumpkin were air-dried, manually shelled, ground, and subjected

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Magomedov, M. G., A. E. Chusova, K. K. Polyansky, O. V. Pronina, and O. N. Romanova. "Technology and instrumentation stevia solutions of spray drying." Proceedings of the Voronezh State University of Engineering Technologies 81, no. 3 (2019): 81–85. http://dx.doi.org/10.20914/2310-1202-2019-3-81-85.

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The relevance of the use and development of sweeteners is reflected in the article. The main requirements for sweeteners were given: the sweetness quality, color and odor absence, a pleasant taste, harmlessness, complete elimination from the body, good solubility in water, chemical resistance. Due to its beneficial properties, the sweetener obtained from stevia leaves is increasingly used. A method of obtaining stevia extract with subsequent drying is presented. The leaves and stems of the Stevia rebaudiana Bertoni plant were used for the experiment. The extract was obtained using water-alcoho

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Shittu, M. D and Alagbe, J.O. "PHYTO-NUTRITIONAL PROFILES OF BROOM WEED (SIDA ACUTA) LEAF EXTRACT." International Journal on Integrated Education 3, no. 11 (2020): 119–24. http://dx.doi.org/10.31149/ijie.v3i11.845.

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Medicinal plants are abundant in phytochemicals that has significant therapeutic effects. They are relatively cheap, effective and safe in prolong use. This experiment was carried out to investigate the phyto-nutritional profile of broom weed (Sida acuta) leaf extract. Proximate analysis Sida acuta leaf indicated the presence of dry matter (91.88 %), crude protein (18.01 %), ash (9.73 %), crude fibre (6.24 %), ether extract (1.77 %) and energy (2760 Kcal/kg). Phytochemical screening of the extract revealed the presence of condensed tannins, hydrolysable tannins, flavonoids, saponins, phenols,

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Nosova, A. S., Yu A. Budanova, and Yu L. Sebyakin. "Structural features of synthetic glycoconjugates and efficiency of their interaction with glycoprotein receptors on the surface of hepatocytes." Fine Chemical Technologies 14, no. 5 (2019): 7–20. http://dx.doi.org/10.32362/2410-6593-2019-14-5-7-20.

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Objectives. Over the last few years, medicinal chemistry research has been focusing on the creation of molecules that can target particular body systems, organs and tissues, thus abating systemic toxicity and side effects, and, most of all, boosting therapeutic potential. This goal can be achieved through the specific interaction of such drugs with active sites of cellular receptors. For example, glycoprotein receptors that can be found on cellular surfaces in neural tissues and liver parenchyma, selectively bind various glycoproteins and glycosides, facilitating their penetration into cells.

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Mousa, Shaker A., Seema Mohamed, Laura O’Connor, and Eric Block. "Sulfur- and Selenium-Containing Compounds Derived from Natural and Synthetic Sources in Angiogenesis Modulation." Blood 104, no. 11 (2004): 3924. http://dx.doi.org/10.1182/blood.v104.11.3924.3924.

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Abstract Increases in serum sulfate may explain some of the therapeutic effects of methylsulfonyl methane (MSM), dimethyl sulfoxide, and glucosamine sulfate. Organic sulfur, as sulfur-containing amino acids, can be used to increase synthesis of S-adenosylmethionine, glutathione, taurine, and N-acetylcysteine. MSM may be effective for the treatment of allergy, pain syndromes, athletic injuries, and bladder disorders. Epidemiological studies have suggested that brassica vegetables are protective against cancers of the lungs and alimentary tract. Cruciferous vegetables are the dietary source of g

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Chen, Xiaodi, Li Xu, Lan Jin та ін. "Efficient and Regioselective Synthesis of β-GalNAc/GlcNAc-Lactose by a Bifunctional Transglycosylating β-N-Acetylhexosaminidase from Bifidobacterium bifidum". Applied and Environmental Microbiology 82, № 18 (2016): 5642–52. http://dx.doi.org/10.1128/aem.01325-16.

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ABSTRACTβ-N-Acetylhexosaminidases have attracted interest particularly for oligosaccharide synthesis, but their use remains limited by the rarity of enzyme sources , low efficiency, and relaxed regioselectivity of transglycosylation. In this work, genes of 13 β-N-acetylhexosaminidases, including 5 fromBacteroides fragilisATCC 25285, 5 fromClostridium perfringensATCC 13124, and 3 fromBifidobacterium bifidumJCM 1254, were cloned and heterogeneously expressed inEscherichia coli. The resulting recombinant enzymes were purified and screened for transglycosylation activity. A β-N-acetylhexosaminidas

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Karole, Sarita, Girendra Gautam, and Shailesh Gupta. "Physicochemical, Qualitative and Quantitative Phytochemical Analysis of the Leaf and Bark of Bombax Ceiba L (Red Silk Cotton Tree)." Journal of Drug Delivery and Therapeutics 8, no. 6-s (2018): 105–10. http://dx.doi.org/10.22270/jddt.v8i6-s.2094.

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Bombax ceiba L is a big deciduous tree found in tropical and subtropical regions of Asia, Africa and Australia. Conventional systems of medicine such as Ayurveda, Siddha and Unani have been highlighted the use of B. ceiba parts (bark, leaves and flower) for the treatment of manydiseases like hypertension, HIV infections, inflammation, catarrhal affection, ulcer, acne, gynecological disorders, fever, dysentery, algesia, hepatotoxicity, piles and urinary infections. The aim of the present study was to evaluate pharmacognostic, physicochemical, qualitative and quantitative phytochemical analysis

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Afu, Gameli, Michael Konney Laryea, and Lawrence Sheringham Borquaye. "Biological Efficacy and Toxicological Evaluation of Ethanolic Extract of Cassia nodosa Buch.-Ham. (Leguminosae)." Journal of Chemistry 2020 (September 27, 2020): 1–13. http://dx.doi.org/10.1155/2020/3983491.

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Medicinal plants are used worldwide to treat various diseases. However, scientific validation of the therapeutic potential of most medicinal plants is absent, and little to no information on their potential toxicity exists. It is therefore important to assess the efficacy and toxicity of various medicinal plants commonly used in traditional herbal medicine. The main goal of this study was to evaluate the efficacy and toxicity of the ethanolic extract of Cassia nodosa, a plant used in the treatment of fever, cold, gastric pain, diabetes mellitus, and malaria in Ghana. The stem bark extract of C

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Omara, Timothy, Ambrose K. Kiprop, and Viola J. Kosgei. "Intraspecific Variation of Phytochemicals, Antioxidant, and Antibacterial Activities of Different Solvent Extracts of Albizia coriaria Leaves from Some Agroecological Zones of Uganda." Evidence-Based Complementary and Alternative Medicine 2021 (June 15, 2021): 1–14. http://dx.doi.org/10.1155/2021/2335454.

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Albizia coriaria Welw ex. Oliver is a customary African medicinal plant, which has a long history of utilization in the management of oxidative stress-induced and bacterial diseases. However, there is no report on the phytochemicals, antioxidant, and antibacterial activities of its leaves. The aim of this study was therefore to compare the phytochemicals, antioxidant, and antibacterial potential of A. coriaria leaves from Jinja, Kole, and Mbarara districts of Uganda. Shade-dried leaf samples were ground into powder and successively extracted with ethyl acetate, ethanol, and distilled water. Ph

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Dadashova, G. M. "Gender differences of response to various options of drug therapy in patients with chronic heart failure after suffered myocardial infarction." Kazan medical journal 97, no. 1 (2016): 17–25. http://dx.doi.org/10.17750/kmj2016-17.

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Aim. To evaluate gender features of treatment in patients with chronic heart failure who suffered myocardial infarction, determine the effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers II, as well as antidepressants in the clinico-functional and psycho-emotional status, morphological and functional parameters of the heart in the treatment of men and women with this pathology.Methods. The study included 205 men and 185 women with chronic heart failure after suffering a myocardial infarction. Patients were randomized into three groups. Patients of the first gro

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Kaplan, Jeffrey B. "Therapeutic Potential of Biofilm-Dispersing Enzymes." International Journal of Artificial Organs 32, no. 9 (2009): 545–54. http://dx.doi.org/10.1177/039139880903200903.

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Surface-attached colonies of bacteria known as biofilms play a major role in the pathogenesis of medical device infections. Biofilm colonies are notorious for their resistance to antibiotics and host defenses, which makes most device infections difficult or impossible to eradicate. Bacterial cells in a biofilm are held together by an extracellular polymeric matrix that is synthesized by the bacteria themselves. Enzymes that degrade biofilm matrix polymers have been shown to inhibit bio film formation, detach established bio film colonies, and render biofilm cells sensitive to killing by antimi

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Bogucka –Kocka, Anna, Michał Woźniak, Marcin Feldo, Janusz Kocki, and Katarzyna Szewczyk. "Diosmin – Isolation Techniques, Determination in Plant Material and Pharmaceutical Formulations, and Clinical Use." Natural Product Communications 8, no. 4 (2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800435.

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Diosmin is a naturally occurring flavone glycoside used in the treatment of venous diseases. In this review, we present the clinical aspects of the use of diosmin preparations in venous stasis, hemorrheologic disorders and vein wall remodeling. Because of its multiple applications in biology and its many therapeutic activities, research on isolation and identification of diosmin is of high relevance. The aim of this review is to present an overview of techniques of isolation and separation of diosmin in plant material, pharmaceutical formulations such as Daflon®, Diosed® and Dioven® tablets, a

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Deepa, Babji, Harsha Babaji, Jagadish Hosmani, et al. "Effect of Tinospora cordifolia-Derived Phytocomponents on Cancer: A Systematic Review." Applied Sciences 9, no. 23 (2019): 5147. http://dx.doi.org/10.3390/app9235147.

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The major cancer therapeutic modalities include surgery, chemotherapy and radiotherapy. Although these treatment regimens have played a significant role in effectively inhibiting cancer, their associated morbidity reduces the overall quality of life. Thus, researchers are striving to identify any alternate therapeutic approach capable of inhibiting cancer without eliciting the added morbidity. Among the alternate cancer therapeutics being researched, much importance is being given to the use of plants due to the presence of a wide variety of anti-carcinogenic compounds. Tinospora cordifolia (T

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Rodríguez-Mayor, Andrea Verónica, German Jesid Peralta-Camacho, Karen Johanna Cárdenas-Martínez, and Javier Eduardo García-Castañeda. "Development of Strategies for Glycopeptide Synthesis: An Overview on the Glycosidic Linkage." Current Organic Chemistry 24, no. 21 (2020): 2475–97. http://dx.doi.org/10.2174/1385272824999200701121037.

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Glycoproteins and glycopeptides are an interesting focus of research, because of their potential use as therapeutic agents, since they are related to carbohydrate-carbohydrate, carbohydrate-protein, and carbohydrate-lipid interactions, which are commonly involved in biological processes. It has been established that natural glycoconjugates could be an important source of templates for the design and development of molecules with therapeutic applications. However, isolating large quantities of glycoconjugates from biological sources with the required purity is extremely complex, because these m

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Didiot, Marie-Cecile, Jeffrey Hewett, Thibault Varin, et al. "Identification of Cardiac Glycoside Molecules as Inhibitors of c-Myc IRES-Mediated Translation." Journal of Biomolecular Screening 18, no. 4 (2012): 407–19. http://dx.doi.org/10.1177/1087057112466698.

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Translation initiation is a fine-tuned process that plays a critical role in tumorigenesis. The use of small molecules that modulate mRNA translation provides tool compounds to explore the mechanism of translational initiation and to further validate protein synthesis as a potential pharmaceutical target for cancer therapeutics. This report describes the development and use of a click beetle, dual luciferase cell-based assay multiplexed with a measure of compound toxicity using resazurin to evaluate the differential effect of natural products on cap-dependent or internal ribosome entry site (I

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Gloster, Tracey M. "Development of inhibitors as research tools for carbohydrate-processing enzymes." Biochemical Society Transactions 40, no. 5 (2012): 913–28. http://dx.doi.org/10.1042/bst20120201.

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Carbohydrates, which are present in all domains of life, play important roles in a host of cellular processes. These ubiquitous biomolecules form highly diverse and often complex glycan structures without the aid of a template. The carbohydrate structures are regulated solely by the location and specificity of the enzymes responsible for their synthesis and degradation. These enzymes, glycosyltransferases and glycoside hydrolases, need to be functionally well characterized in order to investigate the structure and function of glycans. The use of enzyme inhibitors, which target a particular enz

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