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Journal articles on the topic 'Glycosidic Bond Stability'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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1

Xie, Liangqin, Zeyuan Deng, Jie Zhang, et al. "Comparison of Flavonoid O-Glycoside, C-Glycoside and Their Aglycones on Antioxidant Capacity and Metabolism during In Vitro Digestion and In Vivo." Foods 11, no. 6 (2022): 882. http://dx.doi.org/10.3390/foods11060882.

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Flavonoids are well known for their extensive health benefits. However, few studies compared the differences between flavonoid O-glycoside and C-glycoside. In this work, flavonoid O-glycoside (isoquercitrin), C-glycoside (orientin), and their aglycones (quercetin and luteolin) were chosen to compare their differences on antioxidant activities and metabolism during in vitro digestion and in vivo. In vitro digestion, the initial antioxidant activity of the two aglycones was very high; however, they both decreased more sharply than their glycosides in the intestinal phase. The glycosidic bond of

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2

Piskorska, D., and J. Sokolowski. "The Stability of theN-glycosidic bond ofN-aryl-D-pentopyranosylamines." Journal of Carbohydrate Chemistry 5, no. 3 (1986): 475–96. http://dx.doi.org/10.1080/07328308608058851.

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3

Wu, R. R., Yu Chen, and M. T. Rodgers. "Mechanisms and energetics for N-glycosidic bond cleavage of protonated 2′-deoxyguanosine and guanosine." Physical Chemistry Chemical Physics 18, no. 4 (2016): 2968–80. http://dx.doi.org/10.1039/c5cp05738h.

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TCID thresholds of [dGuo/Guo+H]<sup>+</sup> indicate that 2′-hydroxyl strengthens glycosidic bond stability but slightly weakens the competition between the two primary dissociation pathways of [Guo+H]<sup>+</sup>vs. [dGuo+H]<sup>+</sup>.

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4

Bennett, Matthew T., M. T. Rodgers, Alexander S. Hebert, Lindsay E. Ruslander, Leslie Eisele, and Alexander C. Drohat. "Specificity of Human Thymine DNA Glycosylase Depends onN-Glycosidic Bond Stability." Journal of the American Chemical Society 128, no. 38 (2006): 12510–19. http://dx.doi.org/10.1021/ja0634829.

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5

Devereaux, Zachary J., Y. Zhu, and MT Rodgers. "Relative glycosidic bond stabilities of naturally occurring methylguanosines: 7-methylation is intrinsically activating." European Journal of Mass Spectrometry 25, no. 1 (2018): 16–29. http://dx.doi.org/10.1177/1469066718798097.

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The frequency and diversity of posttranscriptional modifications add an additional layer of chemical complexity beyond canonical nucleic acid sequence. Methylations are particularly frequently occurring and often highly conserved throughout the kingdoms of life. However, the intricate functions of these modified nucleic acid constituents are often not fully understood. Systematic foundational research that reduces systems to their minimum constituents may aid in unraveling the complexities of nucleic acid biochemistry. Here, we examine the relative intrinsic N-glycosidic bond stabilities of gu

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6

ZHENG, YAN, YING XUE, and GUO-SEN YAN. "THE INFLUENCES OF OXIDATION AND CATIONIZATION ON THE N-GLYCOSIDIC BOND STABILITY OF 8-OXO-2′-DEOXYADENOSINE — A THEORETICAL STUDY." Journal of Theoretical and Computational Chemistry 08, no. 06 (2009): 1253–64. http://dx.doi.org/10.1142/s0219633609005349.

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This work is an attempt to evaluate theoretically the influences of oxidation and cationization on the N-glycosidic bond stability and the proton and sodium affinities on 8-oxo-2′-deoxyadenosine (8-oxodA) by using the density functional theory (DFT) B3LYP with basis set 6-31++G(d,p). This work shows that the cation attachment to 8-oxodA may modify the equilibrium geometry and bond dissociation. In all modified forms, the length of the N9–C1′ bond in which there is no intramolecular interaction, i.e. O8–H(Na)⋯O4′, increases relative to the neutral system 8-oxodA but that of others decreases. Th

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7

Wu, R. R., and M. T. Rodgers. "Mechanisms and energetics for N-glycosidic bond cleavage of protonated adenine nucleosides: N3 protonation induces base rotation and enhances N-glycosidic bond stability." Physical Chemistry Chemical Physics 18, no. 23 (2016): 16021–32. http://dx.doi.org/10.1039/c6cp01445c.

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N3 protonation induces base rotation and stabilizes the syn orientation of the adenine nucleobase of [dAdo+H]<sup>+</sup> and [Ado+H]<sup>+</sup>via formation of a strong intramolecular N3H<sup>+</sup>⋯O5′ hydrogen-bonding interaction, which in turn influences the mechanisms and energetics for N-glycosidic bond cleavage.

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8

Ipsen, Johan Ø., Magnus Hallas-Møller, Søren Brander, Leila Lo Leggio, and Katja S. Johansen. "Lytic polysaccharide monooxygenases and other histidine-brace copper proteins: structure, oxygen activation and biotechnological applications." Biochemical Society Transactions 49, no. 1 (2021): 531–40. http://dx.doi.org/10.1042/bst20201031.

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Lytic polysaccharide monooxygenases (LPMOs) are mononuclear copper enzymes that catalyse the oxidative cleavage of glycosidic bonds. They are characterised by two histidine residues that coordinate copper in a configuration termed the Cu-histidine brace. Although first identified in bacteria and fungi, LPMOs have since been found in all biological kingdoms. LPMOs are now included in commercial enzyme cocktails used in industrial biorefineries. This has led to increased process yield due to the synergistic action of LPMOs with glycoside hydrolases. However, the introduction of LPMOs makes contr

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9

Das, Rajat S., Milinda Samaraweera, Martha Morton, José A. Gascón, and Ashis K. Basu. "Stability of N-Glycosidic Bond of (5′S)-8,5′-Cyclo-2′-deoxyguanosine." Chemical Research in Toxicology 25, no. 11 (2012): 2451–61. http://dx.doi.org/10.1021/tx300302a.

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10

Bialkowski, Karol, Piotr Cysewsk, and Ryszard Olinski. "Effect of 2'-Deoxyguanosine Oxidation at C 8 Position on N-Glycosidic Bond Stability." Zeitschrift für Naturforschung C 51, no. 1-2 (1996): 119–22. http://dx.doi.org/10.1515/znc-1996-1-219.

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Abstract 8-Oxo-2′-deoxyguanosine, 8-Oxoguanine, 8 -Hydroxyguanine, Base Modification, DNA Oxidative Damage The influence of 2′-deoxyguanosine (dG) oxidation at the C-8 position on N-glycosidic bond stability was in vestigated. A kinetic analysis of dG and 8-oxo-2′-deoxy-guanosine (8-oxodG) depurination reactions was carried out in water solutions at pH ranging from 2 to 7.4 and temperature of 100 °C. The results indicate that N-glyco sidic bond of 8-oxodG is significantly more stable in comparison with dG at any pH applied. At pH 5.1 hydrolysis rate of dG is 4.5-fold higher than that for 8-

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11

Ferenc, Györgyi, Péter Forgó, Zoltán Kele, and Lajos Kovács. "A Regioselective Synthesis of Alkyl 2-(Guanin-9-yl)acetates as PNA Building Blocks from 7-(4-Nitrobenzyl)guanine Derivatives." Collection of Czechoslovak Chemical Communications 70, no. 1 (2005): 85–102. http://dx.doi.org/10.1135/cccc20050085.

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Guanine derivatives substituted at N7 with 4-R-benzyl groups (R = H, MeO, NO2) have been evaluated in the regioselective N9-alkylation of guanine. Given the capricious removal of (substituted) benzyl groups from guanine derivatives and pent-4-enoylation of guaninium hydrochloride, an improved alternative approach has been elaborated consisting in the pent-4-enoylation and per-O-acetylation of guanosine (8), 4-nitrobenzylation at N7 followed by N-glycoside hydrolysis (10), N9-alkylation (13) and deprotection with sodium dithionite to afford the peptide nucleic acid building block tert-butyl [N2

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12

Barnett, Christopher B., Karl A. Wilkinson, and Kevin J. Naidoo. "Pyranose Ring Transition State Is Derived from Cellobiohydrolase I Induced Conformational Stability and Glycosidic Bond Polarization." Journal of the American Chemical Society 132, no. 37 (2010): 12800–12803. http://dx.doi.org/10.1021/ja103766w.

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13

Zhu, Y., Zhihua Yang, and M. T. Rodgers. "Influence of Linkage Stereochemistry and Protecting Groups on Glycosidic Bond Stability of Sodium Cationized Glycosyl Phosphates." Journal of The American Society for Mass Spectrometry 28, no. 12 (2017): 2602–13. http://dx.doi.org/10.1007/s13361-017-1780-2.

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14

Mungi, Chaitanya V., Niraja V. Bapat, Yayoi Hongo, and Sudha Rajamani. "Formation of Abasic Oligomers in Nonenzymatic Polymerization of Canonical Nucleotides." Life 9, no. 3 (2019): 57. http://dx.doi.org/10.3390/life9030057.

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Polymerization of nucleotides under prebiotically plausible conditions has been a focus of several origins of life studies. Non-activated nucleotides have been shown to undergo polymerization under geothermal conditions when subjected to dry-wet cycles. They do so by a mechanism similar to acid-catalyzed ester-bond formation. However, one study showed that the low pH of these reactions resulted in predominantly depurination, thereby resulting in the formation of abasic sites in the oligomers. In this study, we aimed to systematically characterize the nature of the oligomers that resulted in re

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15

Zheng, Yan, Ying Xue, and Guo Sen Yan. "The effects of oxidation and protonation on the N-glycosidic bond stability of 8-oxo-2′-deoxyguanosine: DFT study." Journal of Molecular Structure: THEOCHEM 860, no. 1-3 (2008): 52–57. http://dx.doi.org/10.1016/j.theochem.2008.03.014.

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16

Gudmundsson, Kristjan S., George A. Freeman, John C. Drach та Leroy B. Townsend. "Synthesis of Fluorosugar Analogues of 2,5,6-Trichloro-1-(β-d-ribofuranosyl)benzimidazole as Antivirals with Potentially Increased Glycosidic Bond Stability". Journal of Medicinal Chemistry 43, № 12 (2000): 2473–78. http://dx.doi.org/10.1021/jm990219s.

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17

Kierzek, Elzbieta, Magdalena Malgowska, Jolanta Lisowiec, Douglas H. Turner, Zofia Gdaniec, and Ryszard Kierzek. "The contribution of pseudouridine to stabilities and structure of RNAs." Nucleic Acids Research 42, no. 5 (2013): 3492–501. http://dx.doi.org/10.1093/nar/gkt1330.

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Abstract Thermodynamic data are reported revealing that pseudouridine (Ψ) can stabilize RNA duplexes when replacing U and forming Ψ-A, Ψ-G, Ψ-U and Ψ-C pairs. Stabilization is dependent on type of base pair, position of Ψ within the RNA duplex, and type and orientation of adjacent Watson–Crick pairs. NMR spectra demonstrate that for internal Ψ-A, Ψ-G and Ψ-U pairs, the N3 imino proton is hydrogen bonded to the opposite strand nucleotide and the N1 imino proton may also be hydrogen bonded. CD spectra show that general A-helix structure is preserved, but there is some shifting of peaks and chang

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18

Muhammad Firdaus Kumar, Nurhidayah Kumar, Chew Chee Meng, Nor Hasmaliana Abdul Manas, et al. "Immobilization of maltogenic amylase in alginate-chitosan beads for improved enzyme retention and stability." Malaysian Journal of Fundamental and Applied Sciences 18, no. 1 (2022): 43–51. http://dx.doi.org/10.11113/mjfas.v18n1.2381.

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Maltogenic amylase (Mag1) is a potent enzyme that hydrolyzes the glycosidic bond of polysaccharides to produce malto-oligosaccharides (MOS). However, the Mag1 enzyme has poor stability and reusability, leading to inefficient MOS production. Enzyme immobilization is a promising method to solve the enzyme stability problem. Entrapment and encapsulation technique was used in this study to immobilize Mag1 because of high biocompatibility and prevention of enzyme degradation, hence lesser loss of enzymatic activity. Chitosan was used as a coating membrane on the alginate matrix, preventing enzyme l

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19

Karwowski, Boleslaw. "The difference in stability between 5′R and 5′S diastereomers of 5′,8-cyclopurine-2′-deoxynucleosides. DFT study in gaseous and aqueous phase." Open Chemistry 8, no. 1 (2010): 134–41. http://dx.doi.org/10.2478/s11532-009-0104-1.

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AbstractOxidatively generated damage to DNA frequently appears in the human genome as an effect of aerobic metabolism or as the result of exposure to exogenous oxidizing agents. Due to these facts it has been decided to calculate the stability of 5′,8-cyclo-2′-deoxyadenosine/guanosine (cdA, cdG) in their 5′R and 5′S diastereomeric forms. For all points of quantum mechanics studies presented, the density functional theory (DFT) with B3LYP parameters on 6-311++G** basis set level was used. The calculations showed a significant negative enthalpy for glycosidic bond cleavage reaction for cationic

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20

Ríos-Font, R., J. Bertrán, L. Rodríguez-Santiago, and M. Sodupe. "Effects of Ionization, Metal Cationization and Protonation on 2‘-Deoxyguanosine: Changes on Sugar Puckering and Stability of the N-Glycosidic Bond." Journal of Physical Chemistry B 110, no. 11 (2006): 5767–72. http://dx.doi.org/10.1021/jp056089i.

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21

Park, Gyuri, Byunghwa Kang, Soyeon V. Park, Donghwa Lee, and Seung Soo Oh. "A unified computational view of DNA duplex, triplex, quadruplex and their donor–acceptor interactions." Nucleic Acids Research 49, no. 9 (2021): 4919–33. http://dx.doi.org/10.1093/nar/gkab285.

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Abstract DNA can assume various structures as a result of interactions at atomic and molecular levels (e.g., hydrogen bonds, π–π stacking interactions, and electrostatic potentials), so understanding of the consequences of these interactions could guide development of ways to produce elaborate programmable DNA for applications in bio- and nanotechnology. We conducted advanced ab initio calculations to investigate nucleobase model structures by componentizing their donor-acceptor interactions. By unifying computational conditions, we compared the independent interactions of DNA duplexes, triple

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22

Gudmundsson, Kristjan S., George A. Freeman, John C. Drach та Leroy B. Townsend. "ChemInform Abstract: Synthesis of Fluorosugar Analogues of 2,5,6-Trichloro-1-(β-D-ribofuranosyl)benzimidazole as Antivirals with Potentially Increased Glycosidic Bond Stability." ChemInform 31, № 40 (2000): no. http://dx.doi.org/10.1002/chin.200040197.

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23

Blériot, Yves, Nicolas Auberger, and Jérôme Désiré. "Sugar-Derived Amidines and Congeners: Structures, Glycosidase Inhibition and Applications." Current Medicinal Chemistry 29, no. 7 (2022): 1271–92. http://dx.doi.org/10.2174/0929867329666211222164545.

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Abstract: Glycosidases, the enzymes responsible for the breakdown of glycoconjugates including di-, oligo- and polysaccharides are ubiquitous through all kingdoms of life. The extreme chemical stability of the glycosidic bond combined with the catalytic rates achieved by glycosidases makes them among the most proficient of all enzymes. Given their multitude of roles in vivo, inhibition of these enzymes is highly attractive with potential in the treatment of a vast array of pathologies ranging from lysosomal storage and diabetes to viral infections. Therefore great efforts have been invested in

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24

Thach-Nguyen, Roya, and Trung Dang-Bao. "Noble metal nanoparticles dispersed on nanocellulose: a green platform for catalytic organic transformations." IOP Conference Series: Materials Science and Engineering 1258, no. 1 (2022): 012014. http://dx.doi.org/10.1088/1757-899x/1258/1/012014.

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In recent years, plant-derived biomaterials, typically cellulose, acting as catalytic supports have a great impact on heterogeneous catalysis thanks to their biodegradability, non-toxicity, low-cost, availability and easy-implementation. As the most abundant biopolymer found in nature, cellulose consists of repeating cellobiose units which are built up from two anhydroglucose rings and linked by a β-1,4 glycosidic bond. The term of “nanocellulose” has been widely used to describe cellulose nano-objects, involving cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs) and bacterial cellulo

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25

Oivanen, Mikko, Edward Darzynkiewicz, Harri Lönnberg, et al. "The Influence of Intramolecular Electrostatic Interactions on the Hydrolytic Stability of the N-Glycosidic Bond of 7-Methylguanosine 5'-Monophosphate, a Simple Cap Analogue." Acta Chemica Scandinavica 42b (1988): 250–53. http://dx.doi.org/10.3891/acta.chem.scand.42b-0250.

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26

Jarzembska, Katarzyna N., Katarzyna Ślepokura, Radosław Kamiński, Matthias J. Gutmann, Paulina M. Dominiak, and Krzysztof Woźniak. "Multi-temperature study of potassium uridine-5′-monophosphate: electron density distribution and anharmonic motion modelling." Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials 73, no. 4 (2017): 550–64. http://dx.doi.org/10.1107/s2052520617005534.

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Uridine, a nucleoside formed of a uracil fragment attached to a ribose ringviaa β-N1-glycosidic bond, is one of the four basic components of ribonucleic acid. Here a new anhydrous structure and experimental charge density distribution analysis of a uridine-5′-monophosphate potassium salt, K(UMPH), is reported. The studied case constitutes the very first structure of a 5′-nucleotide potassium salt according to the Cambridge Structural Database. The excellent crystal quality allowed the collection of charge density data at various temperatures,i.e.10, 100, 200 and 300 K on one single crystal. Cr

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27

Tehrani, Zahra Aliakbar, Alireza Fattahi, and Ali Pourjavadi. "Interaction of Mg2+, Ca2+, Zn2+ and Cu+ with cytosine nucleosides: Influence of metal on sugar puckering and stability of N-Glycosidic bond, a DFT study." Journal of Molecular Structure: THEOCHEM 913, no. 1-3 (2009): 117–25. http://dx.doi.org/10.1016/j.theochem.2009.07.026.

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28

Shallom, Dalia, Gali Golan, Gil Shoham та Yuval Shoham. "Effect of Dimer Dissociation on Activity and Thermostability of the α-Glucuronidase from Geobacillus stearothermophilus: Dissecting the Different Oligomeric Forms of Family 67 Glycoside Hydrolases". Journal of Bacteriology 186, № 20 (2004): 6928–37. http://dx.doi.org/10.1128/jb.186.20.6928-6937.2004.

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ABSTRACT The oligomeric organization of enzymes plays an important role in many biological processes, such as allosteric regulation, conformational stability and thermal stability. α-Glucuronidases are family 67 glycosidases that cleave the α-1,2-glycosidic bond between 4-O-methyl-d-glucuronic acid and xylose units as part of an array of hemicellulose-hydrolyzing enzymes. Currently, two crystal structures of α-glucuronidases are available, those from Geobacillus stearothermophilus (AguA) and from Cellvibrio japonicus (GlcA67A). Both enzymes are homodimeric, but surprisingly their dimeric organ

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29

Lebedeva, Natalia Sh, Elena S. Yurina, Sabir S. Guseinov, Yury A. Gubarev, and Anatoly I. V’yugin. "Destruction of Chitosan and Its Complexes with Cobalt(II) and Copper(II) Tetrasulphophthalocyanines." Polymers 13, no. 16 (2021): 2781. http://dx.doi.org/10.3390/polym13162781.

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Chitosan is a naturally occurring polysaccharide derived from chitin with a wide range of uses. Phthalocyanines are macroheterocyclic compounds that have a number of useful properties such as coloring and catalytic and antioxidant activity. Phthalocyanines are able to immobilize on chitosan, forming complexes with new useful properties. In this work, we evaluated the ability of phthalocyanines to increase the thermal stability of chitosan. Chitosan (CS) forms complexes with copper(II)-(CuPc) and cobalt(II)-(CoPc) tetrasulphophthalocyanines. The processes of destruction of chitosan (CS) and its

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30

Shui-Zhong, Luo, Wu Xiang-Zhi, Xu Pei-Lin, et al. "Enzyme-Resistant Dextrin from Chinese Yam Starch for Potential Application in Beverage Industry: Preparation, Physicochemical Properties and In Vitro Digestion." Current Topics in Nutraceutical Research 17, no. 2 (2018): 140–47. http://dx.doi.org/10.37290/ctnr2641-452x.17:140-147.

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Preparation conditions, physicochemical properties and in vitro digestibility of enzyme-resistant dextrin from Chinese yam starches, which are native, easily accessible and cheap raw materials in China, were investigated in the current study. The results showed that the enzyme-resistant fraction content in enzyme-resistant dextrin increased and the whiteness of the enzyme-resistant dextrin decreased with the increasing concentrations of hydrochloric and citric acids and the rising heating temperatures, and the prolonged heating times. Considering the manufacturing cost and the beneficial usage

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31

Zhang, Jijuan, Hongfei Huo, Lei Zhang, et al. "Effect of High-Temperature Hydrothermal Treatment on the Cellulose Derived from the Buxus Plant." Polymers 14, no. 10 (2022): 2053. http://dx.doi.org/10.3390/polym14102053.

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Cellulose has attracted considerable attention as the most promising potential candidate raw material for the production of bio-based polymeric materials. In the last decade, significant progress has been made in the production of biopolymers based on different cellulose forms. In this study, cellulose was obtained in an innovative and environmentally friendly way, using boxwood powder. Crude cellulose was obtained by treating Buxus powder with an ethanol–acetic acid–water mixture. Refined cellulose was then obtained by treatment with an acidic sodium hypochlorite solution and alkaline hydroge

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32

Senchurova, Svetlana I., Aleksandra A. Kuznetsova, Alexander A. Ishchenko, Murat Saparbaev, Olga S. Fedorova, and Nikita A. Kuznetsov. "The Kinetic Mechanism of 3′-5′ Exonucleolytic Activity of AP Endonuclease Nfo from E. coli." Cells 11, no. 19 (2022): 2998. http://dx.doi.org/10.3390/cells11192998.

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Escherichia coli apurinic/apyrimidinic (AP) endonuclease Nfo is one of the key participants in DNA repair. The principal biological role of this enzyme is the recognition and hydrolysis of AP sites, which arise in DNA either as a result of the spontaneous hydrolysis of an N-glycosidic bond with intact nitrogenous bases or under the action of DNA glycosylases, which eliminate various damaged bases during base excision repair. Nfo also removes 3′-terminal blocking groups resulting from AP lyase activity of DNA glycosylases. Additionally, Nfo can hydrolyze the phosphodiester linkage on the 5′ sid

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Jing, Yongshuai, Meng Yan, Hao Zhang, et al. "Effects of Extraction Methods on the Physicochemical Properties and Biological Activities of Polysaccharides from Polygonatum sibiricum." Foods 12, no. 10 (2023): 2088. http://dx.doi.org/10.3390/foods12102088.

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Polygonatum sibiricum polysaccharides (PSPs) have important biological functions, such as antioxidation, immunomodulatory, and hypolipidemic functions. Different extraction methods have effects on their structures and activities. In this study, six extraction methods, including hot water extraction (HWE), alkali extraction (AAE), ultrasound-assisted extraction (UAE), enzyme-assisted extraction (EAE), microwave-assisted extraction (MAE), and freeze–thaw-assisted extraction (FAE) were used to extract PSPs, and their structure–activity relationships were analyzed. The results showed that all six

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Tehrani, Zahra Aliakbar, Alireza Fattahi, and Ali Pourjavadi. "DFT study of the interaction of cytidine and 2′-deoxycytidine with Li+, Na+, and K+: effects of metal cationization on sugar puckering and stability of the N-glycosidic bond." Carbohydrate Research 344, no. 6 (2009): 771–78. http://dx.doi.org/10.1016/j.carres.2009.02.007.

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Malviya, Rishabha, Pramod K. Sharma, and Susheel K. Dubey. "Characterization of Neem (Azadirachita indica) Gum Exudates Using Analytical Tools and Pharmaceutical Approaches." Current Nutrition & Food Science 15, no. 6 (2019): 588–99. http://dx.doi.org/10.2174/1573401314666180821150254.

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Background: Polysaccharide has been used as excipient in pharmaceutical and biomedical sciences. Objective: Objective of present research was to characterize crude Neem Gum Polysaccharide (NGP) for their possible applications in food, cosmetics and pharmaceutical industry. Methods: Purified NGP was characterized in terms of phytochemical screening, organoleptic properties, solubility, micromeritic properties, TLC analysis, ash value, microbial load, molecular confirmation, molecular weight, swelling behaviour, foaming ability, surface morphology, IR spectral analysis, 1H NMR and mass spectra a

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Spohr, Ulrike, Nghia Le, Chang-Chun Ling та Raymond U. Lemieux. "The syntheses of 6-C-alkyl derivatives of methyl α-isomaltoside for a study of the mechanism of hydrolysis by amyloglucosidase". Canadian Journal of Chemistry 79, № 2 (2001): 238–55. http://dx.doi.org/10.1139/v01-005.

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The epimeric (6aR)- and (6aS)-C-alkyl (methyl, ethyl and isopropyl) derivatives of methyl α-isomaltoside (1) were synthesized in order to examine the effects of introducing alkyl groups of increasing bulk on the rate of catalysis for the hydrolysis of the interunit α-glycosidic bond by the enzyme amyloglucosidase, EC 3.2.1.3, commonly termed glucoamylase (AMG). It was previously established that methyl (6aR)-C-methyl α-isomaltoside is hydrolysed about 2 times faster than methyl α-isomaltoside and about 8 times faster than its S-isomer. The kinetics for the hydrolyses of the ethyl and isopropyl

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Méndez-Líter, Juan A., Ana Pozo-Rodríguez, Enrique Madruga, et al. "Glycosylation of Epigallocatechin Gallate by Engineered Glycoside Hydrolases from Talaromyces amestolkiae: Potential Antiproliferative and Neuroprotective Effect of These Molecules." Antioxidants 11, no. 7 (2022): 1325. http://dx.doi.org/10.3390/antiox11071325.

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Glycoside hydrolases (GHs) are enzymes that hydrolyze glycosidic bonds, but some of them can also catalyze the synthesis of glycosides by transglycosylation. However, the yields of this reaction are generally low since the glycosides formed end up being hydrolyzed by these same enzymes. For this reason, mutagenic variants with null or drastically reduced hydrolytic activity have been developed, thus enhancing their synthetic ability. Two mutagenic variants, a glycosynthase engineered from a β-glucosidase (BGL-1-E521G) and a thioglycoligase from a β-xylosidase (BxTW1-E495A), both from the ascom

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Яковишин (Yakovishin), Леонид (Leonid) Александрович (Aleksandrovich), and Владимир (Vladimir) Иванович (Ivanovich) Гришковец (Grishkovets). "MOLECULAR COMPLEXES OF IVY TRITERPENE GLYCOSIDES WITH CHOLESTEROL." chemistry of plant raw material, no. 4 (December 11, 2018): 133–40. http://dx.doi.org/10.14258/jcprm.2018043607.

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Molecular complexes of cholesterol with dominant triterpene saponins from members of the ivy genus Hedera L. (Araliaceae Juss.) – monodesmosidic glycoside α-hederin (hederagenin 3-O-α-L-rhamnopyranosyl-(1→2)-O-α-L-arabinopyranoside) and bisdesmosidic glycoside hederasaponin C (hederagenin 3-O-α-L-rhamnopyranosyl-(1→2)-O-α-L-arabinopyranosyl-28-О-α-L-rhamnopyranosyl-(1→4)-О-β-D-glucopyranosyl-(1→6)-О-β-D-glucopyranoside) as well as with minor monodesmosidic glycoside hederoside F (hederagenin 3-О-β-D-glucopyranosyl-(1→2)-О-β-D-glucopyranoside) have been prepared. The complexation has been inves

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Zhang, Peng, Ning Zhang, Victor E. Buckwold, and Ramachandra S. Hosmane. "Chemical and biological effects of substitution of the 2-position of ring-expanded (‘fat’) nucleosides containing the imidazo[4,5-e][1,3]diazepine-4,8-dione ring system: The role of electronic and steric factors on glycosidic bond stability and anti-HCV activity." Bioorganic & Medicinal Chemistry 15, no. 14 (2007): 4933–45. http://dx.doi.org/10.1016/j.bmc.2007.04.043.

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Supriyantini, Endang, Gunawan Widi Santosa, and Agus Dermawan. "Kualitas Ekstrak Karaginan Dari Rumput Laut “Kappaphycus alvarezii” Hasil Budidaya Di Perairan Pantai Kartini Dan Pulau Kemojan Karimunjawa Kabupaten Jepara." BULETIN OSEANOGRAFI MARINA 6, no. 2 (2017): 88. http://dx.doi.org/10.14710/buloma.v6i2.16556.

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Karaginan merupakan senyawa hidrokoloid yang diekstraksi dari rumput laut merah jenis Kappaphycus alvarezii. Karaginan dapat digunakan untuk meningkatkan kestabilan bahan pangan baik yang berbentuk suspensi (dispersi padatan dalam cairan), emulsi (dispersi gas dalam cairan). Tujuan dari penelitian ini adalah mengetahui Kualitas ekstrak karaginan hasil ekstraksi rumput laut K. alvarezii dari dua lokasi sampling yang berbeda. Penelitian ini dilaksanakan pada bulan Agustus 2015 sampai bulan Januari 2016, di perairan Pantai Kartini, Jepara dan peraian Kemojan Karimunjawa, Jepara. Hasil penelitian

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Yakovishin, L. A., V. D. Ratnikov, P. I. Bazhan, and G. P. Zaitsev. "New molecular complex of ammonium glycyrrhizate with rutin." Chimica Techno Acta 9, no. 1 (2022): 20229101. http://dx.doi.org/10.15826/chimtech.2022.9.1.01.

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A new 1:1 molecular complex of triterpene glycoside ammonium glycyrrhizate (GC) with flavonoid glycoside rutin (Rut) was obtained in aqueous ethanol. The stability constant (9.7±0.2)×104 (mol/L)–1 was calculated for the complex via isomolar curves. The complexation was studied by UV- and ATR IR-Fourier spectroscopy and a method of isomolar series. The hydrogen bonds and hydrophobic interactions are formed in the molecular complex. A preliminary antioxidant activity assessment of the complex was made.

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Yakovishin, L. A., V. I. Grishkovets, E. N. Korzh, I. V. Golovchenko, and A. A. Nagirnyak. "Molecular Complexation of Hederasaponin C with Cholesterol in Aqueous Isopropyl Alcohol." Chimica Techno Acta 7, no. 4 (2020): 150–53. http://dx.doi.org/10.15826/chimtech.2020.7.4.02.

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The 1:1 molecular complex of ivy triterpene glycoside hederasaponin C (HedC) with cholesterol (Chol) was obtained in aqueous isopropyl alcohol. The stability constant of (3.3 ± 0.7)∙106 (mol/L)–1 was calculated for the complex. The complexation was studied by UV- and ATR IR-Fourier spectroscopy, and method of isomolar series. The hydrogen bonds and hydrophobic interactions are formed in the molecular complex.

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De la Luz Ramos, A., G. Pineda Flores, D. Palma-Ramírez, and H. Dorantes-Rosales. "Structural, thermal and morphological studies of bio-based straws under aerobic degradation process." MRS Advances 5, no. 61 (2020): 3113–21. http://dx.doi.org/10.1557/adv.2020.377.

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AbstractThe environmental problems caused by the persistence and improper disposal of single use plastics, have led the worldwide authorities to migrate into a sustainable production of bio-based materials, whose components need to be studied for proving their nature and to confirm their degradability. For this reason, the identification and monitoring degradation of five single use straws were assessed through FT-IR, TGA/DTA and SEM techniques which demonstrate that the straws tagged as biodegradable contain polymers of fossil origin in their formulation. Degradation of them was found to be i

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Mormann, Michael, Hans Paulsen, and Jasna Peter-Katalinić. "Electron Capture Dissociation of O-Glycosylated Peptides: Radical Site-Induced Fragmentation of Glycosidic Bonds." European Journal of Mass Spectrometry 11, no. 5 (2005): 497–511. http://dx.doi.org/10.1255/ejms.738.

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Glycosylation of proteins represents one of the most important post-translational modifications. The structural characterisation of glycoproteins—especially with respect to the determination of the glycosylation site—by direct mass spectrometric methods still remains an elusive goal. We have applied the low energy dissociation method electron capture dissociation (ECD) in a 9.4 T Fourier transform ion cyclotron resonance mass spectrometer to the stuctural elucidation of mucin-derived peptides glycosylated with glycans of different core types. Capture of an electron by multiply protonated precu

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Liang, Rong, Yuxuan Wang, Lina Wu, Xinjiong Ni, and Cheng Yang. "Quaternized Chitosan Modified Nanostructure Lipid Carriers for Topical Delivery of Coenzyme Q10." Nano LIFE 10, no. 04 (2020): 2040013. http://dx.doi.org/10.1142/s1793984420400139.

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Nanostructured lipid carrier (NLC) is a new colloidal delivery system which can effectively solve the problems of stability and transdermal delivery of active ingredients with poor water solubility and biocompatibility. Coenzyme Q10 (CoQ10), as a lipophilic antioxidant, has poor chemical stability due to unsaturated double bonds in its molecular structure, which limits its addition and application in cosmetics. In this study, CoQ10 NLC was prepared using the mixture of Caprylyl/Capryl Glycoside (APG) and quaternized chitosan (QCS). The particle size of the QCS–APG–NLC was around 250 nm. Compar

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Sudijanto, Jason Andrew, and Rukman Hertadi. "In Silico Study on Predicting Effects of H243L Mutation in<i> Bacillus subtilis</i> Levansucrase towards Sucrose Binding Affinity." Materials Science Forum 1061 (May 26, 2022): 119–27. http://dx.doi.org/10.4028/p-43hm23.

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Levan is a branched polysaccharide made from fructose monomers linked by β (2-6) and β (2-1) glycosidic bonds. Levan biosynthesis is catalyzed with levansucrase (EC 2.4.1.10) using sucrose as its substrate. In the present study, we are interested in investigating the elongation capability of the polymerase domain of the enzyme. The other study on Bacillus subtilis levansucrase found that the mutation of His243 into Leu has successfully prolonged the elongation of the polymer. The study, however, has not clearly accounted for the effect of the mutation. The current study aimed to employ in sili

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Pei, Fangyi, Yuze Lv, Xinbo Cao, Xuemeng Wang, Yanxin Ren, and Jingping Ge. "Structural Characteristics and the Antioxidant and Hypoglycemic Activities of a Polysaccharide from Lonicera caerulea L. Pomace." Fermentation 8, no. 9 (2022): 422. http://dx.doi.org/10.3390/fermentation8090422.

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In this study, a novel polysaccharide, LPP, was obtained from Lonicera caerulea L. pomace by ultrasonic-assisted heating and was purified by Sephadex G-100. The structural characteristics of LPP showed that the molecular weight (Mw) was 8.53 × 104 Da; that it was mainly composed of galacturonic acid, followed by galactose; that it possessed the characteristic functional groups of polysaccharides; and that it had an absence of O-glycosidic bonds and crystalline and triple helix structures. Furthermore, LPP exhibited a favorable thermodynamic stability and antioxidant, hypoglycemic, and hypolipi

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Yashim, M. M., M. Mohammad, N. Asim, A. Fudholi, and N. H. Abd Kadir. "Characterisation of microfibrils cellulose isolated from oil palm frond using high-intensity ultrasonication." IOP Conference Series: Materials Science and Engineering 1176, no. 1 (2021): 012004. http://dx.doi.org/10.1088/1757-899x/1176/1/012004.

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Abstract This study highlighted the utilization of agricultural byproducts as an alternative fiber resource to be used as one of the materials for reinforcement biocomposite. Cellulose was extracted from oil palm frond using the alkaline treatment and successfully isolated into microfibril via the combination of carboxymethylation pre-treatment ultrasonication to get highly crystalline and good thermal stable microfibers. 4% NaOH was used during alkaline treatment and followed by oxidative bleaching with 30% H2O2. Once the extracted cellulose is chemically pre-treated with monochloroacetic aci

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Yashim, M. M., M. Mohammad, N. Asim, A. Fudholi, and N. H. Abd Kadir. "Characterisation of microfibrils cellulose isolated from oil palm frond using high-intensity ultrasonication." IOP Conference Series: Materials Science and Engineering 1176, no. 1 (2021): 012004. http://dx.doi.org/10.1088/1757-899x/1176/1/012004.

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Abstract This study highlighted the utilization of agricultural byproducts as an alternative fiber resource to be used as one of the materials for reinforcement biocomposite. Cellulose was extracted from oil palm frond using the alkaline treatment and successfully isolated into microfibril via the combination of carboxymethylation pre-treatment ultrasonication to get highly crystalline and good thermal stable microfibers. 4% NaOH was used during alkaline treatment and followed by oxidative bleaching with 30% H2O2. Once the extracted cellulose is chemically pre-treated with monochloroacetic aci

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Łagiewka, Jakub, Tomasz Girek, and Wojciech Ciesielski. "Cyclodextrins-Peptides/Proteins Conjugates: Synthesis, Properties and Applications." Polymers 13, no. 11 (2021): 1759. http://dx.doi.org/10.3390/polym13111759.

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Cyclodextrins (CDs) are a family of macrocyclic oligosaccharides mostly composed of six, seven, or eight α-D-glucopyranose units with α-1,4-glycosidic bonds to form toroidal structures. The CDs possess a hydrophilic exterior and hydrophobic interior with the ability to form an inclusion complex, especially with hydrophobic molecules. However, most existing studies are about conjugation CDs with peptide/protein focusing on the formation of new systems. The CD-peptide/protein can possess new abilities; particularly, the cavity can be applied in modulation properties of more complexed proteins. M

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