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Journal articles on the topic 'GMDP'

Author: Grafiati

Published: 11 December 2022

Last updated: 31 July 2025

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1

Antsiferova, Yuliya, Nataliya Sotnikova, and Elena Parfenyuk. "Different Effects of the Immunomodulatory Drug GMDP Immobilized onto Aminopropyl Modified and Unmodified Mesoporous Silica Nanoparticles upon Peritoneal Macrophages of Women with Endometriosis." BioMed Research International 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/924362.

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The aim of the present work was to compare in vitro the possibility of application of unmodified silica nanoparticles (UMNPs) and modified by aminopropyl groups silica nanoparticles (AMNPs) for topical delivery of immunomodulatory drug GMDP to the peritoneal macrophages of women with endometriosis. The absence of cytotoxic effect and high cellular uptake was demonstrated for both types of silica nanoparticles. The immobilization of GMDP on the UMNPs led to the suppression of the stimulatory effect of GMDP on the membrane expression of scavenger receptors SR-AI and SR-B, mRNAs expression of NOD

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Kuznetsova, E. G., O. M. Kuryleva, L. A. Salomatina, S. V. Kursakov, S. V. Guryanova, and V. I. Sevastyanov. "Influence of microemulsion components on transdermal delivery of immunomodulator glucosaminylmuramyl dipeptide." Russian Journal of Transplantology and Artificial Organs 22, no. 3 (2020): 149–55. http://dx.doi.org/10.15825/1995-1191-2020-3-149-155.

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This paper demonstrates a chemical way of enhancing transdermal delivery using immunomodulator glucosaminylmuramyl dipeptide (GMDP) as an example. Objective: to study in vitro the effect of various components of the microemulsion composition on GMDP diffusion through the skin from a transdermal therapeutic system (TTS). Materials and methods. Medicinal substance – glucosaminylmuramyl dipeptide (Peptek, Russia). Excipients and raw materials: sodium chloride, purified water, sodium dodecyl sulfate, docusate sodium, oak bark, apricot kernel oil, alpha-tocopheryl acetate and Decaglyn PR-20 emulsif

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Makatsariya, A. D., V. O. Bitsadze, J. Kh Khizroeva, G. Kh Vikulov, M. A. Gomberg, and A. A. Khryanin. "Efficacy and safety of glucosaminylmuramyl dipeptide in treatment of human papillomavirus-associated diseases: a systematic review." Obstetrics, Gynecology and Reproduction 13, no. 2 (2019): 132–54. http://dx.doi.org/10.17749/2313-7347.2019.13.2.132-154.

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Introduction. Human papillomavirus infection (HPV-infection) remains one of the most important health problems as it significantly reduces the quality of life and stigmatizes the patients. Also, the prevalence of cervical cancer – the most severe outcome of the HPV-infection is 5 % of the global burden of cancer. Although vaccination against human papillomavirus has been proved efficient, its availability in Russia continues to be limited. Therefore, it is important to review other methods of HPV-infection control. A number of studies have confirmed the efficacy of glucosaminylmuramyl dipeptid

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Guryanova, Svetlana V., Olga B. Gigani, Georgii O. Gudima, Anastasiya M. Kataeva, and Natalya V. Kolesnikova. "Dual Effect of Low-Molecular-Weight Bioregulators of Bacterial Origin in Experimental Model of Asthma." Life 12, no. 2 (2022): 192. http://dx.doi.org/10.3390/life12020192.

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Asthma is one of the most common noncommunicable diseases, affecting over 200 million people. A large number of drugs control asthma attacks, but there is no effective therapy. Identification of reasons for asthma and preventing this disease is a relevant task. The influence of bacterial components is necessary for the normal development of the immune system and the formation of an adequate immune response to antigens. In the absence of microorganisms or their insufficient exposure, the prerequisites are formed for excessive reactivity to harmless antigens. In the present study, we analyzed ce

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Prodeus, A. P., G. N. Gildeeva, D. R. Mamilyaeva, and I. G. Kozlov. "GLUCOSAMINYLMURAMYLDIPEPTIDE: REVIEW OF USE AND EFFECTIVENESS EVALUATION IN PEDIATRIC PRACTICE." Pediatria. Journal named after G.N. Speransky 100, no. 2 (2021): 157–66. http://dx.doi.org/10.24110/0031-403x-2021-100-2-157-166.

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A review of the accumulated data on the use of glucosaminylmuramyldipeptide (GMDP, Likopid drug) and the assessment of its effectiveness in children are presented. Objective of the research: to systematize the results of clinical trials of the efficacy and safety of GMDP therapy in neonatology and pediatrics. Materials and methods. Publications were searched for in Pubmed/MEDLINE, ScienceDirect, Cochrane, Elibrary.ru, registers of clinical trials and in open sources on the Internet. The authors assessed the level of evidence for reliability and the methodological quality of the studies. Result

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Laman, Alexander G., Richard Lathe, Anna O. Shepelyakovskaya, et al. "Muramyl peptides activate innate immunity conjointly via YB1 and NOD2." Innate Immunity 22, no. 8 (2016): 666–73. http://dx.doi.org/10.1177/1753425916668982.

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Bacterial cell wall muramyl dipeptide (MDP) and glucosaminyl-MDP (GMDP) are potent activators of innate immunity. Two receptor targets, NOD2 and YB1, have been reported; we investigated potential overlap of NOD2 and YB1 pathways. Separate knockdown of NOD2 and YB1 demonstrates that both contribute to GMDP induction of NF-κB expression, a marker of innate immunity, although excess YB1 led to induction in the absence of NOD2. YB1 and NOD2 co-migrated on sucrose gradient centrifugation, and GMDP addition led to the formation of higher molecular mass complexes containing both YB1 and NOD2. Co-immu

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Gudyrev, Oleg, Tatyana Andronova, and Evgeniya Nesterova. "The results of the study of the carcinogenic properties of glucosaminylmuramyldipeptide GMDP in chronic experiments in mice and rats." Research Results in Pharmacology 4, no. 4 (2018): 97–106. http://dx.doi.org/10.3897/rrpharmacology.4.32191.

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Introduction: The drug Licopid® (GMDP, glucosaminylmuramyldipeptide) is intended for complex therapy of conditions accompanied by secondary immunodeficiencies. This drug belongs to the group of microbial immunomodulators of bacterial origin. The transparent mechanism of action of the active substance GMDP allows putting the drug Licopid® into the category of promising immunotherapy drugs that are in demand in the complex therapy of many diseases resistant to traditional treatment. The objective of this study was to investigate the carcinogenicity of GMDP (Licopid®) in chronic animal experiment

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Gudyrev, Oleg S., Tatyana M. Andronova, and Evgeniya I. Nesterova. "The results of the study of the carcinogenic properties of glucosaminylmuramyldipeptide GMDP in chronic experiments in mice and rats." Research Results in Pharmacology 4, no. (4) (2018): 97–106. https://doi.org/10.3897/rrpharmacology.4.32191.

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Introduction: The drug Licopid® (GMDP, glucosaminylmuramyldipeptide) is intended for complex therapy of conditions accompanied by secondary immunodeficiencies. This drug belongs to the group of microbial immunomodulators of bacterial origin. The transparent mechanism of action of the active substance GMDP allows putting the drug Licopid® into the category of promising immunotherapy drugs that are in demand in the complex therapy of many diseases resistant to traditional treatment. The objective of this study was to investigate the carcinogenicity of GMDP (Licopid®) in chronic animal experiment

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9

Nemtsova, E. R., O. A. Bezborodova, N. B. Morozova, et al. "Efficacy of combined treatment of experimental tumors with cytostatic agents and GMDP-A." Russian Journal of Biotherapy 16, no. 2 (2017): 13–22. http://dx.doi.org/10.17650/1726-9784-2017-16-2-13-22.

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Objective of the study. To evaluate the pharmacological effects of N-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-glutamic acid (GMDP-A) as a modifier of biological reactions, i. e. to study its modifying action in regard to traditional cytostatic chemotherapy. Materials and methods. The used drug agents were GMDP-A, cisplatinum, gemcitabine, cyclophosphamide, 5-fluorouracil. The transplanted murine tumors were Р-388 lymphocytic leukemia and S-37 sarcoma (solid and ascites variants), B-16 melanoma, CC-5 squamous cell carcinoma of the cervix uteri, C-26 adenocarcinoma of the colon, and AKATOL

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Guryanova, Svetlana V., and Anastasiya Kataeva. "Inflammation Regulation by Bacterial Molecular Patterns." Biomedicines 11, no. 1 (2023): 183. http://dx.doi.org/10.3390/biomedicines11010183.

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Stimulation of innate immunity by bacterial molecular patterns can induce an enhanced cellular immune response to pathogens that are associated with innate immune memory shaped by epigenetic changes. Immunological memory can be expressed in the acceleration/ intensification of inflammation, as well as in the exact opposite—to maintain tolerance and non-response to a repeated stimulus. Tolerance is one of the central concepts of immunity and is ensured by the consistency of all parts of the immune response. The severe consequences of inflammation force researchers to study in detail all stages

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Bhushan, Monica, Kathleen McElhone, and Christopher EM Griffiths. "GMDP and psoriasis." Lancet 352, no. 9143 (1998): 1857. http://dx.doi.org/10.1016/s0140-6736(05)79923-2.

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Williamson, D., M. Chawla, and R. Marks. "GMDP for psoriasis." Lancet 352, no. 9127 (1998): 545. http://dx.doi.org/10.1016/s0140-6736(05)79253-9.

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13

Nesterova, I. V., V. V. Malinovskaya, S. V. Khaydukov, D. L. Nguyen Thi, G. A. Chudilova, and L. V. Lomtatidze. "DIFFERENTIATED EFFECTS OF GLUCOSAMINYLMURAMILDIPEPTIDE ON THE NONTRANSFORMED AND EXPERIMENTALLY TRANSFORMED PHENOTYPE OF CD62L+CD63+CD66d+ NEUTROPHILIC GRANULOCYTES IN CONVENTIONALLY HEALTHY PEOPLE." Medical Immunology (Russia) 20, no. 6 (2018): 847–54. http://dx.doi.org/10.15789/1563-0625-2018-6-847-854.

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Modern studies have shown a high plasticity and phenotypic diversity of neutrophilic granulocytes (NG) provided by different receptors, which are diagnostic markers for the functional capacity of the cell in the course of their activities. We investigated NG from peripheral blood, obtained from healthy people of both sexes aged from 26 to 66 years. Evaluation of the neutrophil membrane receptor expression was carried out by flow cytometry. The relative amount of neutrophilic granulocytes expressing membrane CD62L, CD63, CD66d receptors and the intensity of their expression were determined acco

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Guryanova, Svetlana V., Artem S. Ferberg, and Ilya A. Sigmatulin. "Inflammatory response modulation by epinephrine and norepinephrine." RUDN Journal of Medicine 27, no. 3 (2023): 329–41. http://dx.doi.org/10.22363/2313-0245-2023-27-3-329-341.

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Relevance. Inflammation is a defense response of an organism to a pathogen. It appears in order to maintain homeostasis and is regulated by the immune, nervous, and endocrine systems. The hormones epinephrine and norepinephrine are produced in the adrenal medulla and in the brain, and are universal messengers that trigger the transmission of nerve impulses at synapses, and also have a receptor-mediated effect on immunocompetent cells. The aim of this study was to investigate adrenergic pathway regulation of inflammation on the neutrophil granulocytes in the presence of activators of innate imm

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Alekseeva, L. G., A. G. Laman, E. A. Meshcherykova, A. O. Shepelyakovskaya, F. A. Brovko, and V. T. Ivanov. "Extracellular Cold Shock Protein YB-1 Induces Tolerance to GMDP and LPS in Mouse Macrophage Cell Line J774." Биоорганическая химия 49, no. 4 (2023): 384–91. http://dx.doi.org/10.31857/s013234232303003x.

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Cold shock protein YB-1 is involved in the regulation of a huge number of fundamental biological processes. Previously, we showed that YB-1 is also involved in the process of recognition of muramylpeptide GMDP by the innate immune receptor NOD2 and is able upon preliminary administration to protect mice from death in a model of septic shock induced by Escherichia coli bacteria. We hypothesized that its protective effect may be associated with the development of a state of tolerance (“nonresponsiveness”). Changes in the cellular response were assessed by the level of mRNA expression of the targ

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Guryanova, Svetlana V., Natalia A. Kudryashova, Anastasiya A. Kataeva, Bubusaira T. Orozbekova, Natalia V. Kolesnikova, and Alexandr G. Chuchalin. "Novel approaches to increase resistance to acute respiratory infections." RUDN Journal of Medicine 25, no. 3 (2021): 181–95. http://dx.doi.org/10.22363/2313-0245-2021-25-3-181-195.

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Relevance . Respiratory infections are the most common in the world. In order to prevent epidemics, there is a need to improve the strategies for organizing medical care and develop new approaches in order to increase the nonspecific resistance, mobilize innate immunity. Objective . The aim of this study was to investigate the effect of glucosaminylmuramyldipeptide (GMDP) on the level of expression of markers of differentiation and activation of functionally significant subpopulations of dendritic cells in peripheral blood mononuclear cells of healthy donors,the second aim was to assess the ef

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17

Konorev, M. R., E. N. Tyshevich, and R. A. Pavlyukov. "Application of N-Acetyl-Glucosaminil-N-Acetyl-Muramyl Dipeptide during Triple Component Anti-Helicobacter Pylori Therapy in the Period of Coronavirus Infection COVID-19." Russian Journal of Gastroenterology, Hepatology, Coloproctology 33, no. 2 (2023): 60–69. http://dx.doi.org/10.22416/1382-4376-2023-33-2-60-69.

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Aim: evaluation of the incidence of COVID-19 infection after three-component H. pylori eradication therapy while taking N-acetyl-glucosaminyl-N-acetyl-muramyl dipeptide (GMDP).Materials and methods. A prospective randomized comparative clinical study was carried out. The study included 208 patients (147 men, 61 women; mean age — 48.1 ± 14.5 years) with duodenal ulcer associated with Helicobacter pylori (H. pylori) who underwent eradication therapy. H. pylori in the gastric mucosa was detected by a morphological method and a rapid urease test before treatment and 6-8 weeks after the end of trea

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Nesterova, I. V., G. A. Chudilova, and Yu V. Teterin. "Ambivalent <i>in vitro</i> effect of immunoregulatory peptides on antigen-presenting subsets of neutrophil granulocytes in purulent inflammatory diseases." Russian Journal of Immunology 28, no. 2 (2025): 287–94. https://doi.org/10.46235/1028-7221-17026-aiv.

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Neutrophilic granulocytes (NG) are functioning as regulators of the immune response. Expression of NG molecules HLA-DR and presentation of antigen to T cells is one of their regulatory mechanisms. The NG dysfunction plays a great role in pathogenesis of acute hematogenous osteomyelitis (AHO) in children. An activated, antigen-presenting NG subset (APC) СD66b+CD16+CD33+HLA-DR+ was also found in these patients. Therefore, studies of surface NG membrane receptor expression, including HLA- DR, their regulation by peptides, and influence of the latter factors on correction on NG effector functions

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Filippenko, A. V., I. A. Ivanova, N. D. Omelchenko, and A. A. Trufanova. "Adjuvant activity of glucosaminylmuramyldipeptide and prospects of its use for the treatment and prevention of infectious diseases." Medical Herald of the South of Russia 15, no. 4 (2024): 72–78. https://doi.org/10.21886/2219-8075-2024-15-4-72-78.

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The purpose of the review was to analyze the literature data on the eﬀect of glucosominylmuramyldipeptide on factors of innate and adaptive immunity in the treatment and prevention of various infectious diseases. The purpose of the review was to examine studies conducted over the past 20 years concerning the use of GMDP for the treatment and prevention of infectious diseases of various etiologies. The literature was searched using databases such as RSCI, eLibrary, MedLine. The following search words were used: muramyldipeptide, muramyldipeptide mechanism of action, glucosominylmuramyldipeptide

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Roh, Tae Hoon, Young Hwa Kim, So Hyun Park, et al. "TMIC-14. DIFFUSE P16INK4A EXPRESSION IS ASSOCIATED WITH TUMOR CELL SENESCENCE AND SENESCENCE-ASSOCIATED SECRETARY PHENOTYPE RELATED TO IMMUNE MICROENVIRONMENT IN GLIOBLASTOMAS." Neuro-Oncology 24, Supplement_7 (2022): vii274. http://dx.doi.org/10.1093/neuonc/noac209.1058.

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Abstract Cellular senescence (CS) is a state of irreversible cell cycle arrest, and the expression of p16INK4a in cells is one of the reliable markers for CS. However, senescent cells are metabolically active with the senescence-associated secretory phenotype (SASP), which can influence the tissue microenvironment by paracrine signaling to the adjacent tumor, non-tumor, and immune cells. In the present study, we evaluated p16INK4a expression in glioblastoma and investigated its association with CS and SASPs. We analyzed the expression of p16INK4a in 73 glioblastomas by immunostaining. To exami

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Kim, S., T. Roh, T. Park, and J. Kim. "P12.01.A TUMOR CELL SENESCENCE AND IMMUNE MICROENVIRONMENT IN GLIOBLASTOMAS." Neuro-Oncology 25, Supplement_2 (2023): ii96. http://dx.doi.org/10.1093/neuonc/noad137.320.

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Abstract BACKGROUND Cellular senescence (CS) is a state of irreversible cell cycle arrest, and the expression of p16INK4a in cells is one of the reliable markers for CS. However, senescent cells are metabolically active with the senescence-associated secretory phenotype (SASP), which can influence the tissue microenvironment by paracrine signaling to the adjacent tumor, non-tumor, and immune cells. MATERIAL AND METHODS In the present study, we evaluated p16INK4a expression in glioblastoma and investigated its association with CS and SASPs. We analyzed the expression of p16INK4a in 73 glioblast

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MacPherson, Sandra. "GMDP - a promising orally active immunomodulator." Inpharma Weekly &NA;, no. 1021 (1996): 3–4. http://dx.doi.org/10.2165/00128413-199610210-00003.

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Wu, Jie, Haixiang Zhang, Jie Feng, et al. "MDPN: Multilevel Distribution Propagation Network for Few-Shot Image Classification." Applied Sciences 13, no. 11 (2023): 6518. http://dx.doi.org/10.3390/app13116518.

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Due to a shortage of labeled examples, few-shot image classification frequently experiences noise interference and insufficient feature extraction. In this paper, we present a two-stage framework based on the distribution propagation graph neural network (DPGN) called the multilevel distribution propagation network (MDPN). An instance-segmentation-based object localization (ISOL) module and a graph-based multilevel distribution propagation (GMDP) module are both included in the MDPN. To create a clear and full object zone, the ISOL module generates a mask that eliminates background and pseudo-

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TURÁNEK, J., A. KAšNÁ, B. KOUDELA, M. LEDVINA, and A. D. MILLER. "Stimulation of innate immunity in newborn kids againstCryptosporidium parvuminfection-challenge by intranasal/per-oral administration of liposomal formulation of N-L18-norAbu-GMDP adjuvant." Parasitology 131, no. 5 (2005): 601–8. http://dx.doi.org/10.1017/s0031182005007924.

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The effects of a liposomal preparation of lipophilic immunomodulator β-D-GlcNstearoyl-(1-4)-norMurNAc-L-Abu-D-isoGln (N-L18-norAbu-GMDP) were investigated on resistance toCryptosporidium parvuminfection in neonatal kids. The liposomal preparation was administered subcutaneously or intranasally/orally (i.n./p.o.) twice at doses of 100 μg, 200 μg, or 1000 μg per kid pre-infection challenge. The treatment schemes were (i) 72 and 24 h pre-infection challenge, (ii) 24 h pre-infection challenge and 24 h post-infection challenge (oral inoculation with 1×107oocysts ofC. parvumin 5 ml of PBS). Administ

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Хоперская, О. В., Е. В. Енькова, Л. К. Джиджихия та Д. А. Чимшит. "Эффективность и безопасность применения глюкозаминилмурамилдинептида в терапии папилломавирусной инфекции". Issues of practical colposcopy. Genital infections, № 1 (4 квітня 2025): 13–24. https://doi.org/10.46393/27826392_2025_1_13-24.

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В статье освещены вопросы этиологии, патогенеза, течения и лечения папилломавирусной инфекции. Длительная персистенция вируса папилломы человека (ВПЧ) способна привести к злокачественной трансформации многослойного плоского эпителия шейки матки. Пик заболеваемости в молодом возрасте диктует необходимость поиска консервативных методов воздействия на ВПЧ-инфекцию с целью повышения вероятности элиминации вируса. Проанализирована взаимосвязь между инфицированностью ВПЧ и бактериальным вагинозом, при котором чаще наблюдаются персистенция и рецидивирование ВПЧ. Приведены результаты клинических иссле

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Golovina, T. N., L. V. Samochvalova, I. S. Litvinov, G. Fattachova, and V. A. Nesmeyanov. "Biochemical characterization of GMDP binding sites on murine macrophages." Immunology Letters 56 (May 1997): 68. http://dx.doi.org/10.1016/s0165-2478(97)85259-5.

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Golovina, T. "Biochemical characterization of GMDP binding sites on murine macrophages." Immunology Letters 56, no. 1-3 (1997): 68. http://dx.doi.org/10.1016/s0165-2478(97)87097-6.

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Kalyuzhin, Oleg V., Tatiana M. Andronova, and Alexander V. Karaulov. "BCG, muramylpeptides, trained immunity (part II): a low molecular weight alternative to multicomponent bacterial immunostimulants for prevention of respiratory infections during a pandemic." Terapevticheskii arkhiv 93, no. 1 (2021): 108–13. http://dx.doi.org/10.26442/00403660.2021.01.200554.

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During a pandemic, nonspecific immunoprophylaxis of SARS-CoV-2 infection and other acute respiratory infections (ARI), which can worsen the course of COVID-19, is increasingly in demand in addition to specific immunization. BCG vaccine appears to be one of the candidate immunostimulants in this regard. At the same time, other microbe-derived preparations capable of inducing a state of trained immunity deserve attention. BCG and other bacterial immunostimulatory agents containing a large number of biologically active subunits have long been considered as objects of search for promising pharmaco

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Fernandes Júnior, Francisco, Edson Luis de Azambuja Ribeiro, Amanda de Freitas Pena, Fernando Augusto Grandis, Lais Neri Vidotto, and Thaís Campos de Freitas. "Parâmetros Produtivos de Cordeiros Santa Inês e Dorper Abatidos com Diferentes Espessuras de Gordura Subcutânea." Ensaios e Ciência C Biológicas Agrárias e da Saúde 27, no. 1 (2023): 70–78. http://dx.doi.org/10.17921/1415-6938.2023v27n1p70-78.

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Objetivou-se avaliar o desempenho produtivo, parâmetros do plasma sanguíneo e medidas morfométricas de cordeiros confinados Santa Inês e Dorper, castrados e não castrados, abatidos com diferentes espessuras de gordura subcutânea (EGS) avaliadas por ultrassonografia in vivo. Foram utilizados 69 cordeiros machos de dois grupos genéticos, sendo 34 Santa Inês e 35 Dorper. Destes, metade de cada grupo foi castrado. Os abates e o tempo de confinamento foram da seguinte forma: Dorper com 1,5 mm de EGS: 27 dias; Santa Inês com 1,5 mm EGS: 39 dias; Santa Inês e Dorper com 2,7 mm EGS: 84 dias e Santa In

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Petrova, Elena E., Maria A. Simonova, Ravilya L. Komaleva та ін. "GMDP augments antitumor action of the CP/TNFα combination in vivo". Biomedicine & Pharmacotherapy 64, № 4 (2010): 240–48. http://dx.doi.org/10.1016/j.biopha.2009.06.019.

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Meshcheryakova, Elena A., Konstantin S. Mineev, Pavel E. Volynski, Tatiana M. Andronova та Vadim T. Ivanov. "GMDP: unusual physico-chemical and biological properties of the anomeriс forms". Journal of Peptide Science 21, № 9 (2015): 717–22. http://dx.doi.org/10.1002/psc.2796.

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KOLESNIKOVA, N. V. "CLINICAL AND IMMUNOLOGICAL EFFICACY OF MURAMYLDIPEPTIDE (GMDP) IN FERTILITY DISORDERS (scientific review)." Kubanskij nauchnyj medicinskij vestnik, no. 5 (January 1, 2017): 120–28. http://dx.doi.org/10.25207/1608-6228-2017-24-5-120-128.

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Nesterova, I. V., G. A. Chudilova, V. N. Pavlenko, S. V. Kovaleva, V. A. Tarakanov, and N. K. Barova. "Effects of NOD1 and NOD2 agonists polymuramyl as well as NOD2 agonist glucosaminylmuramyldipeptide on phenotype of neutrophile granulocyte CD64-CD16+CD32+CD11b+, CD16+CD62L+CD63-, CD16+CD62L+CD63+ subsets." Russian Journal of Immunology 23, no. 4 (2020): 411–18. http://dx.doi.org/10.46235/1028-7221-455-eon.

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Antimicrobial activity of neutrophilic granulocytes (NG) is based on effective recognition and elimination of microbial pathogens, as well as on complex intracellular signal transduction pathways interconnecting these processes. NG dysfunction leads to emergence of atypical infectious and inflammatory diseases recalcitrant to standard interventions, which requires new vector platforms aimed at restoring normal NG functioning and overcoming antibiotic resistance. Moreover, we emphasize about special interest paid to the NOD1 and NOD2 agonist polymuramyl and NOD2 agonist glucosaminylmuramyldipep

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Khalturina, Evgeniya O., N. V. Garskova, and A. D. Shemetova. "Personalized approach to immune system rehabilitation in patients with year-round allergic rhinitis suffering from recurrent ARVI and recurrent herpes virus infections." Russian Journal of Infection and Immunity 14, no. 3 (2024): 623–31. http://dx.doi.org/10.15789/2220-7619-pat-16826.

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Introduction. The problem of treating patients with respiratory allergopathology associated with recurrent infectious diseases, such as rARVI, frequent exacerbations of rCHVI, is becoming urgent. The presence of persistent inflammation and co-infection significantly complicates the treatment of immunocompromised patients with year-round allergic rhinitis (YAR) and necessitates the development of personalized programs, with the inclusion of immunomodulatory agents for restoring disorders in the immune system (IS) and interferon system (IFN). Materials and methods. The study group (SG) included

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Guryanova, Svetlana V., Ilya A. Sigmatulin, Olga O. Gigani, and Sofia A. Lipkina. "Mechanisms of Regulation Allergic and Autoimmune Reactions by Bacterial Origin Bioregulators." RUDN Journal of Medicine 27, no. 4 (2023): 470–82. http://dx.doi.org/10.22363/2313-0245-2023-27-4-470-482.

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Relevance. The increase in allergic and autoimmune diseases observed in recent decades highlights the need for therapy and prevention, which requires detailed research into the mechanisms of their occurrence. The onset and progression of allergic and autoimmune diseases are influenced by genetic predisposition, lifestyle, environmental factors, and disruptions in the coordinated operation of the immune system, and as a consequence of immune homeostasis. Treatment of these diseases is primarily symptomatic and often accompanied by undesirable side effects. Immune system disorders in various pat

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Guryanova, S. V., and R. M. Khaitov. "Glucosaminylmuramyldipeptide - GMDP: effect on mucosal immunity (on the issue of immunotherapy and immunoprophylaxis)." Immunologiya 41, no. 2 (2020): 174–83. http://dx.doi.org/10.33029/0206-4952-2020-41-2-174-183.

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Guryanova, S. V., A. M. Gaponov, V. M. Pisarev, et al. "Glucosaminylmuramyl dipeptide acid (GMDP-A) modulates intracellular signaling pathways in natural killer cells." Immunologiya 41, no. 3 (2020): 235–48. http://dx.doi.org/10.33029/0206-4952-2020-41-3-235-248.

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Linzner, Dominik, and Heinz Koeppl. "A Variational Perturbative Approach to Planning in Graph-Based Markov Decision Processes." Proceedings of the AAAI Conference on Artificial Intelligence 34, no. 05 (2020): 7203–10. http://dx.doi.org/10.1609/aaai.v34i05.6210.

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Coordinating multiple interacting agents to achieve a common goal is a difficult task with huge applicability. This problem remains hard to solve, even when limiting interactions to be mediated via a static interaction-graph. We present a novel approximate solution method for multi-agent Markov decision problems on graphs, based on variational perturbation theory. We adopt the strategy of planning via inference, which has been explored in various prior works. We employ a non-trivial extension of a novel high-order variational method that allows for approximate inference in large networks and h

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Zhao, Xiaoqing, Kun Tan, Pengfei Xie, Bing Chen, and Junwei Pu. "Multiobjective Land-Use Optimization Allocation in Eucalyptus-Introduced Regions Based on the GMDP–ACO Model." Journal of Urban Planning and Development 147, no. 2 (2021): 05021004. http://dx.doi.org/10.1061/(asce)up.1943-5444.0000664.

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TITOV, VLADIMIR M., ELENA A. MESHCHERYAKOVA, TAMARA A. BALASHOVA, TATYANA M. ANDRONOVA, and VADIM T. IVANOV. "Synthesis and immunological evaluation of the conjugates composed from a muramyl peptide GMDP and tuftsin." International Journal of Peptide and Protein Research 45, no. 4 (2009): 348–55. http://dx.doi.org/10.1111/j.1399-3011.1995.tb01048.x.

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Guryanova, S., Roman Khanferyan, T. Andronova, and Lawrence M. Dubuske. "Impact of the NOD2 ligand GMDP on IgE and Cytokine Production in Allergy and Immune Deficiency." Journal of Allergy and Clinical Immunology 143, no. 2 (2019): AB109. http://dx.doi.org/10.1016/j.jaci.2018.12.332.

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Li, C. G., S. Kumar, P. W. Ledger, J. M. Ponting, M. Carette, and E. Allan. "Glucosaminylmuramyl dipeptide (GMDP) modulates endothelial cell activities in vitro but has no effect on angiogenesis in vivo." Inflammation Research 46, no. 9 (1997): 348–53. http://dx.doi.org/10.1007/s000110050200.

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Alekseeva, L. G., A. G. Laman, E. A. Meshcherykova, A. O. Shepelyakovskaya, F. A. Brovko, and V. T. Ivanov. "Extracellular Cold Shock Protein YB-1 Induces Tolerance to GMDP and LPS in Mouse Macrophage Cell Line J774." Russian Journal of Bioorganic Chemistry 49, no. 4 (2023): 751–57. http://dx.doi.org/10.1134/s1068162023030032.

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Knotigová, Pavlína Turánek, Daniel Zyka, Josef Mašek, et al. "Molecular Adjuvants Based on Nonpyrogenic Lipophilic Derivatives of norAbuMDP/GMDP Formulated in Nanoliposomes: Stimulation of Innate and Adaptive Immunity." Pharmaceutical Research 32, no. 4 (2015): 1186–99. http://dx.doi.org/10.1007/s11095-014-1516-y.

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Adeleye, T. A., C. Moreno, J. Ivanyi та R. Aston. "The modulation of tumour necrosis factor-α, interleukin-1α and glucose levels with GMDP and other analogues of muramyl dipeptide". APMIS 102, № 1-6 (1994): 145–52. http://dx.doi.org/10.1111/j.1699-0463.1994.tb04859.x.

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Nguyen, Yen T. M., Manabu Fujisawa, Tran B. Nguyen, et al. "S100a8/S100a9-Emmprin-Vegfa Axis Initiated By Tet2-Deficient Immune Cells Exacerbates Lung Cancer Progression through Promotion of Angiogenesis." Blood 138, Supplement 1 (2021): 3276. http://dx.doi.org/10.1182/blood-2021-151723.

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Abstract Introductions: Loss-of-function TET2 mutations are frequent in clonal hematopoiesis in patients with solid cancers as well as that in healthy individuals. It remains to be elucidated whether and how TET2-mutated immune cells affect cancer progression in patients with TET2-mutated clonal hematopoiesis. Here, we assessed activity of Tet2-deficient immune cells using a mouse lung cancer model. Methods: Lewis Lung Carcinoma (LLC) cells were subcutaneously transplanted into blood-specific Mx-Cre or myeloid-specific LysM-Cre x Tet2 f/f mice (Tet2 -/- or Tet2 mye-) or control mice (CT). Sing

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Khmel’nitskij, Roman A., and Аndrej V. Vislobokov. "Clinical feasibility study of an immunotropic drug for treatment of complicated pyodermas." Research Results in Pharmacology 6, no. 3 (2020): 51–57. http://dx.doi.org/10.3897/rrpharmacology.6.50797.

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Introduction: Given a wide range of pathogenesis of the inflammatory process in pyoderma, which involves a variety of links in the immune response, work is underway to find ways to optimize immunocorrection in this pathology. The aim of the study was to evaluate the clinical and economic effectiveness of immunocorrection in severe and chronic forms of pyoderma with drugs from different pharmacological groups. Materials and methods: The data sources were prospective randomized comparative studies of therapy of 107 pyoderma patients aged 18 to 60 years, divided into groups. The patients of the f

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Khmel'nitskij, Roman A., and Andrej V. Vislobokov. "Clinical feasibility study of an immunotropic drug for treatment of complicated pyodermas." Research Results in Pharmacology 6, no. (3) (2020): 51–57. https://doi.org/10.3897/rrpharmacology.6.50797.

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Introduction: Given a wide range of pathogenesis of the inflammatory process in pyoderma, which involves a variety of links in the immune response, work is underway to find ways to optimize immunocorrection in this pathology. The aim of the study was to evaluate the clinical and economic effectiveness of immunocorrection in severe and chronic forms of pyoderma with drugs from different pharmacological groups. Materials and methods: The data sources were prospective randomized comparative studies of therapy of 107 pyoderma patients aged 18 to 60 years, divided into groups. The patients of the f

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Lyons, K. "Factors limiting the oral bioavailability of N-acetylglucosaminyl-N-acetylmuramyl dipeptide (GMDP) and enhancement of absorption in rats by delivery in a water-in-oil microemulsion." International Journal of Pharmaceutics 199, no. 1 (2000): 17–28. http://dx.doi.org/10.1016/s0378-5173(00)00349-5.

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Laman, A. G., A. O. Shepelyakovskaya, Kh M. Boziev, G. V. Savinov, F. A. Brovko, and V. A. Nesmeyanov. "A method for the preparation of adjuvant peptide mimetics of GMDP with the use of monoclonal antibodies and combinatorial libraries of peptides in the format of phage display." Russian Journal of Bioorganic Chemistry 36, no. 2 (2010): 157–63. http://dx.doi.org/10.1134/s1068162010020032.

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