Relevant bibliographies by topics / GMH

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'GMH'

Author: Grafiati
Published: 10 January 2023
Last updated: 28 January 2023

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Journal articles on the topic "GMH"

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Prajapati, Anuj Kumar, Pushkar Verma, Satyansh Singh, and Monoj Kumar Mondal. "Adsorption-Desorption Surface Bindings, Kinetics, and Mass Transfer Behavior of Thermally and Chemically Treated Great Millet Husk towards Cr(VI) Removal from Synthetic Wastewater." Adsorption Science & Technology 2022 (January 28, 2022): 1–16. http://dx.doi.org/10.1155/2022/3956977.

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This study reports the efficacy of adsorbents synthesized by thermal (TT-GMH) and chemical (CT-GMH) modification of great millet husk (GMH) for the treatment of synthetic wastewater containing Cr(VI). The chemical modification of raw GMH was done by concentrated H2SO4 to increase the porosity and heterogeneity on the surface. The comparative investigations of physicochemical properties of synthesized adsorbents were examined by point of zero charge (pHpzc), BET surface area, SEM-EDX, FTIR, and XRD analyses. The results revealed that CT-GMH had around three times higher surface area and more porous structure as compared to TT-GMH. The adsorption experiments were executed in batch mode to examine the impact of parameters governing the adsorption process. For Cr(VI) solution of 25 mg/L, adsorbent dose of 4 g/L, temperature of 25 ° C , and shaking speed of 150 RPM, the maximum removal for TT-GMH was attained at pH 1 and contact time 150 min, while for CT-GMH, maximum removal was attained at pH 2 and contact time 120 min. The experimental results fitted to the rate kinetic equations showed that for both TT-GMH and CT-GMH, adsorbents followed the quasi-second-order kinetic model during the adsorption process. Further, results revealed that the adsorption process was endothermic and Sips isotherm model was followed for both TT-GMH and CT-GMH. Based on the Sips isotherm, maximum uptake capacity for TT-GMH and CT-GMH was noted to be 16 and 22.21 mg/g, respectively. Among the tested mass transfer models, liquid film diffusion model was followed during the adsorption process of both the adsorbents. The desorption study revealed that TT-GMH and CT-GMH give 69.45% and 74.48% removal, respectively, up to six cycles.
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Rajabzadeh, Vian, Erin Burn, Sana Z. Sajun, Mimi Suzuki, Victoria Jane Bird, and Stefan Priebe. "Understanding global mental health: a conceptual review." BMJ Global Health 6, no. 3 (March 2021): e004631. http://dx.doi.org/10.1136/bmjgh-2020-004631.

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BackgroundMental health disorders are viewed as a global concern requiring globally led approaches to address them. Since the publication of the 2007 Lancet series on global mental health (GMH), the term has become widespread. Over the last two decades, GMH has become increasingly affiliated with policy reform, academic courses, funding bodies and research. However, it is not always obvious how those working in the field of GMH are using the term, resulting in a lack of clarity. Therefore, work is needed to synthesise the current understanding(s) of GMH to help characterise its meaning.AimTo synthesise the literature and identify the different ways GMH is understood.MethodA conceptual review, using a systematic search and a content analysis, was conducted to develop a conceptual framework of the different conceptual understandings of GMH.ResultsWe developed a conceptual framework of four understandings of GMH. These understandings of GMH are as follows: an area of research generating findings to establish a GMH evidence-base; implementation of research into practice; improving the mental health environment; learning from and supporting low-and-middle-income countries (LMICs).ConclusionOur review proposes a simple framework, clarifying the key characteristics of the GMH landscape. The findings highlight the diversity of usage of the term in the literature, as well as present the wide scope that comprises the field of GMH. Referring to this framework may help those engaged with GMH to be more specific with which aspect of the field they are concerned with.
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Andersson, Erik Axel, Eridan Rocha-Ferreira, Henrik Hagberg, Carina Mallard, and Carl Joakim Ek. "Function and Biomarkers of the Blood-Brain Barrier in a Neonatal Germinal Matrix Haemorrhage Model." Cells 10, no. 7 (July 2, 2021): 1677. http://dx.doi.org/10.3390/cells10071677.

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Germinal matrix haemorrhage (GMH), caused by rupturing blood vessels in the germinal matrix, is a prevalent driver of preterm brain injuries and death. Our group recently developed a model simulating GMH using intrastriatal injections of collagenase in 5-day-old rats, which corresponds to the brain development of human preterm infants. This study aimed to define changes to the blood-brain barrier (BBB) and to evaluate BBB proteins as biomarkers in this GMH model. Regional BBB functions were investigated using blood to brain 14C-sucrose uptake as well as using biotinylated BBB tracers. Blood plasma and cerebrospinal fluids were collected at various times after GMH and analysed with ELISA for OCLN and CLDN5. The immunoreactivity of BBB proteins was assessed in brain sections. Tracer experiments showed that GMH produced a defined region surrounding the hematoma where many vessels lost their integrity. This region expanded for at least 6 h following GMH, thereafter resolution of both hematoma and re-establishment of BBB function occurred. The sucrose experiment indicated that regions somewhat more distant to the hematoma also exhibited BBB dysfunction; however, BBB function was normalised within 5 days of GMH. This shows that GMH leads to a temporal dysfunction in the BBB that may be important in pathological processes as well as in connection to therapeutic interventions. We detected an increase of tight-junction proteins in both CSF and plasma after GMH making them potential biomarkers for GMH.
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Pereyra, Fernando, Jorge Ignacio Urioste, Diego Gimeno, Francisco Peñagaricano, Dorrel Bentancur, and Ana Espasandín. "Parámetros genéticos en la etapa de cría para el cruzamiento entre Hereford y Angus en campo natural." Agrociencia 19, no. 1 (June 2015): 140–49. http://dx.doi.org/10.31285/agro.19.330.

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En un experimento dialélico entre las razas Hereford (H/H) y Aberdeen Angus (A/A) desarrollado entre los años 1994 y 2002 en la Estación Experimental Bernardo Rosengurtt de la Facultad de Agronomía-Udelar, Uruguay, se estimaron diferencias en efectos genéticos directos (gIA-gIH) y efectos genéticos maternos (gmA-gmH), efectos de heterosis individual (hIAH) y materna (hmAH) mediante modelos lineales para condición corporal al parto (CCP), peso al nacimiento (PN), y peso al destete (PD), y usando modelos lineales generalizados para porcentaje de destete (% D). En CCP los efectos raciales y la heterosis estimada no fueron significativas, en tanto para PN la diferencia en kg fue negativa, siendo superior H/H (-1,18±0,42 kg, P=0,0051). Para PD la diferencia entre efectos maternos (gmA – gmH) resultó positiva, con 4,87±1,01 kg (P=0,0001), y la heterosis individual fue de 5,12±1,24 kg (P=0,0001). Para el % D, la hIAH fue de 0,22± 0,03. La hmAH resultó significativa para PD (11,58±1,48 kg, P=0,0001). Al nacimiento los terneros H/H, A/H y H/A fueron más pesados que los A/A. En % D las madres cruza en promedio superan en 24,7 unidades (14,9 %) a las puras (85,0 vs 60,3). Al destete los terneros hijos de madres híbridas fueron significativamente más pesados (promedio 159,1 kg). Las madres Hereford destetaron los terneros significativamente más livianos (promedio 143,3 kg); mientras que los terneros hijos de madres Angus pesaron 151,6 kg.
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Si, Yuan, Xi Liu, Kaixiong Ye, Alessandro Bonfini, Xun Yang Hu, Nicolas Buchon, and Zhenglong Gu. "Glucomannan Hydrolysate Promotes Gut Proliferative Homeostasis and Extends Life Span in Drosophila melanogaster." Journals of Gerontology: Series A 74, no. 10 (September 25, 2018): 1549–56. http://dx.doi.org/10.1093/gerona/gly189.

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Abstract Dietary supplementation of glucomannan has been shown to have multiple health benefits, but its effect on life span has not been investigated. Here, we show that glucomannan hydrolysate (GMH) treatment extends mean life span of the model organism Drosophila melanogaster. To unravel the underlying mechanisms, we first examined the effect of GMH on the gut microbiota. We found that GMH treatment is associated with an elevated bacterial load in aged flies but overall has limited effects on the relative microbiota composition. We also demonstrated that GMH inhibits age-associated hyperproliferation of intestinal stem cells and thus delays the deterioration of gut integrity. Further analysis of the midgut transcriptome revealed that both EGFR/MAPK and JAK/STAT signaling pathways are suppressed in GMH groups. Multiple key regulators or effectors of EGFR/MAPK pathway, Ets21c, Mkp3, and Rho, are downregulated by GMH treatment. In the JAK/STAT pathway, major ligands (eg, Upd2 and Upd3) and negative feedback inhibitors (eg, Socs36e) are all significantly downregulated. Additionally, the expression of genes encoding antimicrobial peptides is elevated by GMH treatment. Taken together, our study shows that dietary supplementation of GMH can prolong life span, possibly through regulating gut proliferative homeostasis.
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Tortora, Domenico, Mariasavina Severino, Mariya Malova, Alessandro Parodi, Giovanni Morana, Jan Sedlacik, Paul Govaert, Joseph J. Volpe, Andrea Rossi, and Luca Antonio Ramenghi. "Differences in subependymal vein anatomy may predispose preterm infants to GMH–IVH." Archives of Disease in Childhood - Fetal and Neonatal Edition 103, no. 1 (June 6, 2017): F59—F65. http://dx.doi.org/10.1136/archdischild-2017-312710.

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Background and purposeThe anatomy of the deep venous system plays an important role in the pathogenesis of brain lesions in the preterm brain as shown by different histological studies. The aims of this study were to compare the subependymal vein anatomy of preterm neonates with germinal matrix haemorrhage–intraventricular haemorrhage (GMH–IVH), as evaluated by susceptibility-weighted imaging (SWI) venography, with a group of age-matched controls with normal brain MRI, and to explore the relationship between the anatomical features of subependymal veins and clinical risk factors for GMH–IVH.MethodsSWI venographies of 48 neonates with GMH–IVH and 130 neonates with normal brain MRI were retrospectively evaluated. Subependymal vein anatomy was classified into six different patterns: type 1 represented the classic pattern and types 2–6 were considered anatomic variants. A quantitative analysis of the venous curvature index was performed. Variables were analysed by using Mann-Whitney U and χ2 tests, and a multiple logistic regression analysis was performed to evaluate the association between anatomical features, clinical factors and GMH–IVH.ResultsA significant difference was noticed among the six anatomical patterns according to the presence of GMH–IVH (χ2=14.242, p=0.014). Anatomic variants were observed with higher frequency in neonates with GMH–IVH than in controls (62.2% and 49.6%, respectively). Neonates with GMH–IVH presented a narrower curvature of the terminal portion of subependymal veins (p<0.05). These anatomical features were significantly associated with GMH–IVH (p<0.05).ConclusionPreterm neonates with GMH–IVH show higher variability of subependymal veins anatomy confirming a potential role as predisposing factor for GMH–IVH.
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Whitley, Rob. "Global Mental Health: concepts, conflicts and controversies." Epidemiology and Psychiatric Sciences 24, no. 4 (June 1, 2015): 285–91. http://dx.doi.org/10.1017/s2045796015000451.

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This paper introduces, describes and analyses the emerging concept of Global Mental Health (GMH). The birth of GMH can be traced to London, 2007, with the publication of a series of high-profile papers inThe Lancet. Since then, GMH has developed into a movement with proponents, adherents, opponents, an ideology and core activities. The stated aims of the Movement for GMH are ‘to improve services for people living with mental health problems and psychosocial disabilities worldwide, especially in low- and middle-income countries where effective services are often scarce’. GMH could be considered an attempt to right a historic wrong. During the colonial and post-colonial eras, the mental health of subject populations was accorded a very low priority. This was fuelled by scientific racism, which alleged that mental illness was uncommon in places such as Africa. As developing nations have made the epidemiological transition, the burden of mental illness has proportionately increased, with research suggesting a massive ‘treatment gap’ between those in need and those actually receiving formal mental health care. As such, much GMH research and action has been devoted to: (i) the identification and scale-up of cost-effective evidence-supported interventions that could be made more widely available; (ii) task-shifting of such intervention delivery to mental-health trained non-specialist Lay Health Workers. GMH has come under sustained critique. Critics suggest that GMH is colonial medicine come full circle, involving the top-down imposition of Western psychiatric models and solutions by Western-educated elites. These critiques suggest that GMH ignores the various indigenous modalities of healing present in non-Western cultures, which may be psychologically adaptive and curative. Relatedly, critics argue that GMH could be an unwitting Trojan horse for the mass medicalisation of people in developing countries, paving the way for exploitation by Big Pharma, while ignoring social determinants of health.
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Liu, Shengpeng, Jerry J. Flores, Bo Li, Shuixiang Deng, Gang Zuo, Jun Peng, Jiping Tang, and John H. Zhang. "IL-20R Activation via rIL-19 Enhances Hematoma Resolution through the IL-20R1/ERK/Nrf2 Pathway in an Experimental GMH Rat Pup Model." Oxidative Medicine and Cellular Longevity 2021 (January 19, 2021): 1–15. http://dx.doi.org/10.1155/2021/5913424.

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Aims. Blood clots play the primary role in neurological deficits after germinal matrix hemorrhage (GMH). Previous studies have shown a beneficial effect in blood clot clearance after hemorrhagic stroke. The purpose of this study is to investigate interleukin-19’s role in hematoma clearance after GMH and its underlying mechanism of IL-20R1/ERK/Nrf2 signaling pathway. Methods. A total of 240 Sprague-Dawley P7 rat pups were used. GMH was induced by intraparenchymal injection of bacterial collagenase. rIL-19 was administered intranasally 1 hour post-GMH. IL-20R1 CRISPR was administered intracerebroventricularly, or Nrf2 antagonist ML385 was administered intraperitoneally 48 hours and 1 hour before GMH induction, respectively. Neurobehavior, Western blot, immunohistochemistry, histology, and hemoglobin assay were used to evaluate treatment regiments in the short- and long-term. Results. Endogenous IL-19, IL-20R1, IL-20R2, and scavenger receptor CD163 were increased after GMH. rIL-19 treatment improved neurological deficits, reduced hematoma volume and hemoglobin content, reduced ventriculomegaly, and attenuated cortical thickness loss. Additionally, treatment increased ERK, Nrf2, and CD163 expression, whereas IL-20R1 CRISPR-knockdown plasmid and ML385 inhibited the effects of rIL-19 on CD163 expression. Conclusion. rIL-19 treatment improved hematoma clearance and attenuated neurological deficits induced by GMH, which was mediated through the upregulation of the IL-20R1/ERK/Nrf2 pathways. rIL-19 treatment may provide a promising therapeutic strategy for the GMH patient population.
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Dimitar, Ivanov, Asenova Dorina, and Hadjidekov George. "A Spectrum of MRI Findings in Germinal Matrix Hemorrhages: A Case Series." International journal of Gynecology, Obstetrics and Neonatal Care 7 (September 28, 2022): 1–5. http://dx.doi.org/10.15379/2408-9761.2022.07.01.

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The germinal matrix hemorrhage (GMH) can be diagnosed prenatally by ultrasound (US) and fetal magnetic resonance imaging (MRI). Prenatal imaging is essential for GMH grading and subsequent prognosis and clinical management. MRI benefits from higher specificity and sensitivity for GMH diagnosis then ultrasound. Fetal MRI advantages include high-resolution imaging, better visualization of the brain parenchyma with susceptibility to identify hemorrhage or blood breakdown products and non-invasiveness of the study. This article aims to present a series of cases with fetal GMH.
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Langley, Emily A., Stephanie M. Blake, and Kristi L. Coe. "Recent Review of Germinal Matrix Hemorrhage–Intraventricular Hemorrhage in Preterm Infants." Neonatal Network 41, no. 2 (March 1, 2022): 100–106. http://dx.doi.org/10.1891/11-t-722.

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Germinal matrix hemorrhage–intraventricular hemorrhage (GMH–IVH) is a particular type of intracranial hemorrhage that affects the preterm population. GMH–IVH originates from bleeding within the highly vascular area near the center of the brain known as the germinal matrix. The pathogenesis of GMH–IVH is unclear; it is likely related to hemodynamic changes and fluctuations in cerebral blood flow within a fragile developing brain. Cranial ultrasound is the primary diagnostic test and reveals the degree of GMH–IVH based on a grading system. Management includes prevention of preterm delivery with meticulous antenatal and postnatal preventative strategies. This article discusses current evidence specific to the pathogenesis, risk factors, diagnosis, grading scales, and management approaches with GMH–IVH in preterm infants.
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Dissertations / Theses on the topic "GMH"

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Petruškevičiūtė, Erika. "Genetiškai modifikuotų organizmų gamybos ir naudojimo teisinis reguliavimas bei įtaka aplinkai ir visuomenei." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140603_111446-84625.

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Magistro baigiamajame darbe atskleista, kad daugelis respondentų yra neapsisprendę dėl savo pozicijos GMO gamybos bei naudojimo atžvilgiu, tačiau beveik trečdalis asmenų GMO gamybai bei naudojimui nepritaria. Dauguma gyventojų mano, kad GMO ne tik kenkia žmogaus sveikatai, bet ir yra pavojingi, taip pat kenkia aplinkai, o GMO turinčių produktų naudojimas gali negrįžtamai pakeisti genetinį žmogaus kodą ir augalų bei gyvūnų populiacijose gali sukelti negrįžtamus mutacinius pokyčius. Vis dėlto GMO produkciją kai kurie gyventojai linkę naudoti dėl mažesnės jų kainos ir ilgesnio vartojimo galiojimo termino. Nors kai kurie respondentai ir buvo įsitikinę GMO teikiama nauda bei tolimesniu GMO gamybos bei naudojimo plitimu ateityje, tačiau beveik visi respondentai buvo įsitikinę ir tuo, jog GMO gamyba bei naudojimu labiausiai suinteresuotos yra kuo didesnio pelno siekiančios monopolinės kampanijos. Vienareikšmiškai galima teigti, jog nors gyventojai apie GMO informacijos daugiausiai ir gauna iš televizijos laidų, pokalbių su draugais pažįstamais ar giminaičiais bei iš spaudos leidinių arba naršydami internete, tačiau tos informacijos kiekis yra nepakankamas ir daugiau kaip pusė respondentų norėtų, jog informacijos apie GMO būtų pateikiama daugiau.
The Master’s final paper on GMO discovered that the majority of respondents have no strong opinion about production and use of GMO, but one third of responses on production and use of GMO were negative. Many people consider that GMO not only negatively affect human health, but also damage environment. Moreover, eating genetically-modified food can irreversibly change human’s genetic code as well as irreversible mutations in plants’ and animals’ populations. However, some people tend to use GM foods because they are cheaper and can be stored longer than other foods. Even though some of the respondents see benefits of GMO production and usage, almost all of the respondents claim that genetically engineered products interest mostly large companies that are seeking to profit from GMO. The most obvious finding to emerge from this study is that people learn about GMO from mass media and communicating with friends and relatives mostly, but they also admit the lack of credible information on GMO. More than a half of the respondents would like to receive more information about genetically modified organisms.
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Arthur, Julian. "Novel Therapies and Biochemical Insights for the GM1 and GM2 Gangliosidoses." Thesis, Boston College, 2011. http://hdl.handle.net/2345/3855.

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Thesis advisor: Thomas N. Seyfried
Gangliosides are glycosphingolipids (GSLs) containing sialic acids that play numerous roles in neuronal maturation, apoptotic signaling, angiogenesis, and cell surface receptor activity. The GM1 and GM2 gangliosidoses are a series of autosomal recessive lysosomal storage disorders (LSDs) characterized by an inability to degrade these lipid molecules. GM1 gangliosidosis is caused by a mutation in the lysosomal hydrolase β-galactosidase, resulting in neuronal storage of ganglioside GM1 and asialo GA1. Tay-Sachs (TS) and Sandhoff Disease (SD) are GM2 gangliosidoses caused by mutations in either the α or β subunits, respectively, of the heterodimeric protein β- hexosaminidase A, resulting in the storage of ganglioside GM2 and asialo GA2. The accumulation of excess ganglioside in the central nervous system leads to abnormal intracellular vacuoles, neuronal loss, demyelination, ataxia, dementia, and premature death. In my studies, I have shown that accumulation of GM1 ganglioside may not coincide with secondary storage of cholesterol, by providing evidence that cholesterol-binding fluorescent molecule filipin reacted to GM1 ganglioside in the absence of cholesterol. In an effort to combat the early-onset gangliosidoses, I have explored the effects of combining Neural Stem Cells (NSCs) with Substrate Reduction Therapy (SRT) in juvenile Sandhoff mice. The analysis showed that SRT was more effective than NSCs in reducing stored GM2 and GA2 in young mice, and no synergy was observed. In adult GM1 gangliosidosis, Tay- Sachs, and Sandhoff mice, Adeno-Associated Viral (AAV) vector gene therapy was used to restore therapeutic levels of wild-type enzyme to the CNS. AAV therapy corrected ganglioside storage and ameliorated myelin-associated lipid loss in all tissues assayed, increasing motor performance and life in effected animals. Lastly, AAV therapy was also successful in a feline model of Sandhoff disease. These results in juvenile and adult model systems point the way towards multiple effective clinical therapies in the near future
Thesis (PhD) — Boston College, 2011
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Biology
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Sundin, Charlotta. "Risker med GMO i jordbruket." Thesis, Södertörn University College, School of Life Sciences, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-2934.

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The world is growing more and more genetically modified (or engineered) crops (GM crops). In Argentina farmers grow almost only GM soy, and no conventional soy. It is a controversial subject, since genetic engineering has many advocates and critics. The positive sides of GM crops are that it can create higher yields and incomes for the farmers. Those are the main objects of growing GM crops. Critics, on the other hand, say that GM crops have bad effects on the environment, and the risks could be too high. For example GM crops can spread to neighboring farms, where organic crops are growing. Many scientists claim that nobody really have enough knowledge of the effects of growing GM crops, and therefore thorough risk assessments are needed to examine the effects and possible risks of growing GM crops before starting to grow them. Politicians, too often, make decisions on false scientific grounds, when they claim that genetic engineering is a safe and precise method. The large corporations developing GMOs are heavily influencing political decision making. Scientists have studied the genetic engineering process and the results show that the method is not precise. It is difficult to know exactly what gene is transferred, and where it ends up. It is also important to discuss the precautionary principle in the decision making process.

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Bieliauskienė, Rūta. "Visuomenės informavimas ir žinių įvertinimas apie genetiškai modifikuotus produktus ir jų poveikį sveikatai." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2006. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2006~D_20060612_143049-66330.

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Introduction. Theme of modern biotechnologies is an especially topical question, because there is no simple answer about possible harm to nature and human health done by Genetically Modified Organisms (hereinafter referred to as GMO) until now. On the other side, biotechnology industry is a future industry, which provides great possibilities to improve the welfare of whole nations. Survey of Lithuanian public opinion shows that society thinks of GMO not very favorably and inhabitants treat those new products not well enough; with a great care and do not trust in their safety. Public institutions do not pay much attention for public information campaigns. Paper objective. Research and estimation of society knowledge and information distribution concerning GMO and GMP and their possible impact on human health. Tasks. 1. To examine public knowledge related to GMO and GMP. 2. To explore public knowledge related to a possible risk of GMP for a human health. 3. To evaluate effectiveness of public information distribution structures while familiarizing the society with GMO and GMP and their influence on human health. 4. To suggest measures and ways for improvement of the distribution of public information concerning GMO and GMP. Research methods. Paper objective was to explore public knowledge on GMO, GMP and its impact on human health. Research has been carried out using methods of data analysis, comparison, generalization and questionnaire interview. The statistical data... [to full text]
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Meyu, Louria SUNTA ANAK. "DO EXPORTS AND GMO REGULATIONS DETERMINE ADOPTION RATE OF GM CROPS BY EXPORTING COUNTRIES." OpenSIUC, 2020. https://opensiuc.lib.siu.edu/theses/2770.

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This thesis examines the role of exports and GMO regulations of the exporting country on the adoption of GM crops by its farmers. The analytic sample includes five major exporting countries including Argentina, Brazil, China, India, and Mexico. I focus only on the crop that is widely grown in each country. The crops are cotton, maize, and soybean. GMO regulations indices, which were constructed by Vigani et al, consists of four categories of different regulations related to import of GMO products. Relative impact of different aspects of GMO regulations on exports are assessed to get a better understanding of domestic production decisions of farmers in major exporting countries. The result for the approval process, risk assessment and international agreement suggested that, these regulations are not significant to influence the adoption rate of the GM crops. The exporting countries, especially the developing countries, usually reluctant to implement the GM regulations because of the high cost of completing the procedures.
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Johansson, Adam. "Evaluation of Bone Contrast Enhanced MRI Sequences and Voxel Based Segmentation." Thesis, Umeå universitet, Radiofysik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-37560.

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An ultra-short echo time (UTE) magnetic resonance imaging (MRI) sequence was used together with other MRI sequences to evaluate the possibility of segmenting air, soft tissues and bone. Three patients were imaged with the UTE sequence and other sequences as well as with computed tomography (CT). An algorithm using Gaussian mixture models was developed and applied to the problem of segmenting the MR images. A similar algorithm was developed and used to generate an artificial CT image from the MR data. The images of the first patient were used as training data for the algorithms and the images of the other two patients were used for validation. It was found that less than 20 percent of the volume inside the head was misclassified and that the root mean square error of the artificial CT image was less than 420 Hounsfield units. Finally a volunteer was imaged in the same way but with an additional UTE sequence with a larger flip angle. The results suggested that the additional image may improve segmentation further.
En sekevens för bildgivande magnetresonans (MRI) med ultrakort ekotid (UTE) användes tillsammans med andra MRI-sekvenser till att utvärdera möjligheten att segmentera luft, mjukvävnad och ben. Bilder togs av tre patienter med UTE-sekvensen och med övriga sekvenser samt med datortomografi (CT). En algoritm baserad på en blanding av normalfördelningar utvecklades och tillämpades på MR-segmenteringsproblemet.En likande algoritm utvecklades och användes till att skapa en konstgjord CT-bild utifrån MR-bilderna.Bilderna tagna av den första patienten användes till att träna algoritmerna medan bilderna av de två andra patienterna användes för validering. Mindre än 20 procent av volymen inuti huvudet felklassificerades och det kvadratiska medelvärdet av avvikelserna i den konstgjorda CT-bilden var mindre än 420 hounsfieldenheter. Slutligen togs bilder av en frivillig på samma sätt men med ytterligare en UTE-sekvens med en större flippvinkel. Resultatet antyder att den nya bilden kan bidra till en förbättrad segmentering.
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Liudvinavičiūtė, Eglė. "Genetiškai modifikuotų organizmų ir genetiškai modifikuotų produktų teisinio reguliavimo problemos." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2008~D_20090908_194047-28380.

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Neatsiejama genetiškai modifikuotų organizmų (GMO) bei iš jų pagamintų produktų (GMP) teisinio reguliavimo dalis yra mokslas bei politika. –iame darbe analizuojamas GMO (GMP) teisinio reguliavimo raida ES ir Lietuvos Respublikoje. Nagrinėjamos tokios GMO ir GMP teisinio reguliavimo problemos, kaip etikos nuostatų suderinimas su žmogaus genų naudojimu kuriant maistui skirtus produktus; ES institucijų ir valstybių narių pozicijų išsikyrimas siekiant uždrausti apgalvotą GMO išleidimą į aplinką; visuomenės dalyvavimo priimant sprendimus dėl GMO (GMP) problematika ES ir Lietuvos Respublikoje – visuomenės „motyvuotos nuomonės“ instituto neefektyvumas. Taip pat analizuojamos ES teisės nuostatų dėl sankcijų nustatymo už GMO (GMP) reguliuojančių teisės aktų pažeidimus įgyvendinimo Lietuvos Respublikoje problemos t.y. nacionalinėje teisėje nenustačius atsakomybės pagrindiniams su GMO (GMP) veikla susijusiems juridiniams asmenims, praktiškai išlieka jų nebaudžiamumas; tai pat pažymėtina, kad teisės aktų, reglamentuojančių GMO ir GMP naudojimą, reikalavimų pažeidimai yra pakankamai skirtingo pobūdžio, o ATPK jie išvardinti viename straipsnyje, kartu numatyta gana didelis skiriamos baudos mažiausias dydis, - visa tai praktikoje sąlygoja nuobaudų neskyrimą bei neužtikrina Direktyvoje 2001/18/EB įtvirtintos sankcijos veiksmingumo, proporcingumo ir atgrasumo. Darbe nagrinėjamos tarptautinių sutarčių - Biologinės įvairovės ir Orhuso konvencijų - nuostatos dėl GMO bei jų įtaka ES ir Lietuvos... [toliau žr. visą tekstą]
Science and politics are part and parcel of law regulation of genetically modified organisms (GMO) and products (GMP) made from them. This work analyses development of law regulation of GMO (GMP) in ES and Lithuanian Republic. Such problems as ethical attitude towards usage of human genes in food production, distinction of ES isntitutions and member states according to their position, in purpose to forbid deliberate release of GMO into environment, problems of society involvment in taking decisions about GMO (GMP) in ES and Lithuanian Republic, inefficiency of public institute of "motivated opinion" (public comments) are disscussed in this work. Such topics as realisation of ES rules for definition of sanctions for breaking laws of GMO (GMP) usage in Lithuania Republic and rules of international contracts, such as Cartagena protocol on biosafety to the convention on biological diversity and Orhus convention, and their influence upon law regulation in ES and Lithuanian Republic are also disscussed here.
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Sefton, Martin. "Ständiga förbättringar och praktisk problemlösning : en explorativ studie på Saab Automobile AB." Thesis, University West, Department of Engineering Science, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-1638.

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Continuous improvement is one of five principles in General Motors – Global Manufacturing System (GM-GMS). GM-GMS has been used by Saab Automobile AB since 2003 and is a central component for realisation of GM’s vision. Internal audits have discovered problems with one of the tools, practical problem solving (PPS), which needs to be improved. The department manufacturing of press and body (PK) wants to survey the problems and initiate a process of improvement. The purpose of this thesis work is to develop a foundation for future re-designs of the PPS process. Employees have been interviewed and observed in order to explore possible difference theoretical and practical problem solving with PPS. The result of the investigation shows 4 different and interrelated problem categories. 1. Information transfer, PPS hand over to product quality engineers (PQE) department cause problem when general assemblies (GA) are excluded from the improvement work. General assemblies do not get any feedback information from (PQE) about planed countermeasures. 2. Problem solving, team leaders has difficulties with identifying the true problem. Using “five-why” during the analysis work causes problem, since team leaders do not have the knowledge of how to use the tool in a proper way. 3. Documentation of PPS, the content in the PPS-form is a problem according to team leaders. Lack of knowledge and understanding of how to use the PPS-document leads to incomplete and incorrect analysis. 4. Coordination of involved people, support and help are missing from the management and quality engineer according team leaders. PPS from Global Costumer Audit are imposing time stress according to team leaders. Recommendations for further work is to investigate the opportunities with a web based PPS and process to improve information transfer and documentation of PPS. A second recommendation is to train and coach team leaders in problem solving and improve coordination of involved people and skills in problem solving.

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Jansen, van Rijssen Fredrika W. "Analysis of the credibility of South African risk governance of genetically modified organisms and pesticides." Thesis, University of Pretoria, 2013. http://hdl.handle.net/2263/37369.

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In this study, two diverse scientific areas of research, namely, biological-chemical and public administration, were drawn upon to find an answer for improved risk governance of genetically modified organisms (GMO/GM) and pesticides. The need for such a study appeared from the constraints experienced with regulatory approval of GMO crops in South Africa. The knowledge gained from research on risk governance of GMOs could also be applied to pesticides. Protracted procedures causing delays in approval and increasingly stringent regulatory requirements of GMOs resulted in negative implications for research, development and commercialisation. Approval of several South African co-developed GMOs has been delayed or rejected that resulted in withdrawal or reducing of research activities, apart from appeals against decisions. The objective of the study was to identify some of the reasons for delays as experienced in risk assessments and to propose remedial actions, including the critical interface between role players in risk governance. The approach taken in this research was to obtain, by means of a questionnaire, a broad view of risk governances of GMOs as measured with criteria of good governance experienced by scientists of biotechnology and related disciplines. This was followed by another questionnaire with focus on one specific area that caused delays for GMO permit applicants. The investigation included analysis of South African legislation, guidelines and interviews. The research on risk assessment narrowed down to the two areas, illustrated by South African applicable case studies, namely, food risk/safety assessment of GMO cassava and environmental risk assessment of GMO sorghum. Approaches to improve assessments are being recommended. Uncertainty in risk assessment is an important reality because of humankind‘s limited knowledge of nature. Uncertainty is further addressed by precautious management, described as the precautionary principle is a norm legislated by the South African government in line with international agreements (the Cartagena Protocol on Biosafety). The terminology, precautionary approach and principle are used interchangeably in literature. The application of the precautionary principle in South African legislation and the difficulty that could be experienced in decision making are illustrated in the case study on ‗possible unintended changes in endogenous allergens‘ in GMO maize. The research showed the importance of timely risk communication between risk assessors, risk managers (decision makers) and stakeholders in advance of the commencement of risk assessment. The importance of timely consideration of socio-economic impact of GMOs and pesticides is touched on. Risk governance structures, for both GMOs and pesticides are proposed, based on the most democratic and transparent governance models taking into consideration the European initiatives for improved risk governance. This included an interface for interaction among role players, namely, risk assessors, risk managers, scientists and stakeholders. The up-front role of an array of scientists, as the most trustworthy communicators in contentious scientific issues, is of specific importance because of the fast developing and very broad field of genetic modification of many crops. South Africa‘s national research institutes should play a much bigger role as scientific advisors in scientific risk policy making and framing for risk assessments. It is of great importance that risk assessments are focused on risks and not on the gathering of bucketsful of data; therefore, training in approaches to assessment of risk should be a priority. To achieve improvement on risk governance, the importance of policy development and the roles of all participants should be clear. Proposals for future research cover the many aspects that comprise trust in governance and the increased awareness of consumers and stakeholders of environmental risks and food safety. This study also paves a way for research on governance of phytopesticides and phytomedicines because of growing interest in these rich sources of new information that could be of great benefit to mankind.
Thesis (PhD)--University of Pretoria, 2013.
gm2014
Paraclinical Sciences
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Koehler, Dirk. "Die GmbH in der Schweiz und in Deutschland : ein Rechtsvergleich unter Einschluss des schweizerischen Reformprojekts und unter Berücksichtigung ihrer Eignung als Projektträgergesellschaft für Joint Ventures /." Zürich ; Basel ; Genf : Schulthess, 2005. http://aleph.unisg.ch/hsgscan/hm00145963.pdf.

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Books on the topic "GMH"

1

Dick, Claésson, ed. GDH. Göteborg: Litterär gestaltning, Göteborgs universitet, 2010.

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Bleasdale, Alan. GBH. London: Hutchinson, 1987.

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Zorn, Nikolaus. Besteuerung der Geschäftsführung bei GmbH, GmbH & CoK(E)G, GmbH & Still. Wien: Wirtschaftsverlag A. Orac, 1992.

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Wohlmann, Herbert. GmbH-Recht. Basel: Helbing & Lichtenhahn, 1997.

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Kanwal, Salma. Panah gah. Lahore: Alhayaat, 1999.

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Proceedings, of the Third International Symposium on the Gerasimov-Drell-Hearn Sum Rule and Its Extensions (. GDH 2004. Singapore: World Scientific Publishing, 2005.

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Khayat, S. A. Gour gah. Tehran: Hirmand, 1999.

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Vogel, Patric U. B. GMP-Risikoanalysen. Wiesbaden: Springer Fachmedien Wiesbaden, 2021. http://dx.doi.org/10.1007/978-3-658-35208-0.

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Kim, Cheorl-Ho. GM3 Signaling. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-5652-4.

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Engelhardt, Clemens. Die GmbH. Wiesbaden: Springer Fachmedien Wiesbaden, 2020. http://dx.doi.org/10.1007/978-3-658-28573-9.

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Book chapters on the topic "GMH"

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Lekic, Tim, Damon Klebe, Jerry Flores, Regina Peters, William B. Rolland, Jiping Tang, and John H. Zhang. "Remote Ischemic Postconditioning (RIPC) After GMH in Rodents." In Acta Neurochirurgica Supplement, 63–67. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-18497-5_11.

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Chung, Ellen. "Right Germinal Matrix Hemorrhage (GMH)." In Pediatric Imaging Cases, 165–66. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199758968.003.0078.

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Mai, Roberto, and Laura Tassi. "Invasive EEG in Grey Matter Heterotopia." In Invasive Studies of the Human Epileptic Brain, edited by Samden D. Lhatoo, Philippe Kahane, and Hans O. Lüders, 235–45. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198714668.003.0018.

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Grey matter heterotopias (GMH) are in the malformations of cortical development group of disorders, comprising an entity of abnormal neuronal migration, triggering patterns of cortical and neuronal disarrangement. Normal but misplaced tissue within the original organ characterizes heterotopias. They share the same signal intensity as adjacent cortical grey matter, are bilateral or unilateral, diffuse or localized, with subependymal, subcortical, or transmantle localization. Genetic causes are common, particularly in bilateral cases. Drug-resistant epilepsy is the main symptom; surgery should be planned early. Invasive recordings are considered mandatory, and stereo-EEG is the most suitable exploration methodology. Both GMH and surrounding cortices may originate discharges. Surgery demonstrates good results, especially when a lesionectomy (even when incomplete) is associated with a corticectomy. Recently, thermocoagulation of the GMH and cortices encompassed within the epileptogenic zone has provided a therapeutic approach in selected, even bilateral, cases. Laser interstitial thermal therapy needs further evaluation in these patients.
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Bridges, Robert Seymour. "12 September 1867 From Robert Bridges To GMH." In The Collected Works of Gerard Manley Hopkins, Vol. 1: Correspondence 1852–1881, edited by R. K. R. Thornton and Catherine Phillips, 155–56. Oxford University Press, 2013. http://dx.doi.org/10.1093/oseo/instance.00150743.

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"20 May [1879] From Walter Pater To GMH." In The Collected Works of Gerard Manley Hopkins, Vol. 1: Correspondence 1852–1881, edited by R. K. R. Thornton and Catherine Phillips, 358. Oxford University Press, 2013. http://dx.doi.org/10.1093/oseo/instance.00150890.

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Bridges, Robert Seymour. "15 June 1881 From Robert Bridges To GMH." In The Collected Works of Gerard Manley Hopkins, Vol. 1: Correspondence 1852–1881, edited by R. K. R. Thornton and Catherine Phillips, 449. Oxford University Press, 2013. http://dx.doi.org/10.1093/oseo/instance.00150937.

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Patmore, Coventry Kersey Deighton. "14 August 1883 From Coventry Patmore To GMH." In The Collected Works of Gerard Manley Hopkins, Vol. 2: Correspondence 1882–1889, edited by R. K. R. Thornton and Catherine Phillips. Oxford University Press, 2013. http://dx.doi.org/10.1093/oseo/instance.00151018.

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Patmore, Coventry Kersey Deighton. "19 August 1883 From Coventry Patmore To GMH." In The Collected Works of Gerard Manley Hopkins, Vol. 2: Correspondence 1882–1889, edited by R. K. R. Thornton and Catherine Phillips, 595. Oxford University Press, 2013. http://dx.doi.org/10.1093/oseo/instance.00151021.

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Patmore, Coventry Kersey Deighton. "14 September 1883 From Coventry Patmore To GMH." In The Collected Works of Gerard Manley Hopkins, Vol. 2: Correspondence 1882–1889, edited by R. K. R. Thornton and Catherine Phillips. Oxford University Press, 2013. http://dx.doi.org/10.1093/oseo/instance.00151025.

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Patmore, Coventry Kersey Deighton. "18 September 1883 From Coventry Patmore To GMH." In The Collected Works of Gerard Manley Hopkins, Vol. 2: Correspondence 1882–1889, edited by R. K. R. Thornton and Catherine Phillips. Oxford University Press, 2013. http://dx.doi.org/10.1093/oseo/instance.00151027.

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Conference papers on the topic "GMH"

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Chen, Jie, William Watson III, and Weizhen Mao. "GMH: A Message Passing Toolkit for GPU Clusters." In 2010 IEEE 16th International Conference on Parallel and Distributed Systems (ICPADS). IEEE, 2010. http://dx.doi.org/10.1109/icpads.2010.35.

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Zhang, Yao, Hongru Liang, Adam Jatowt, Wenqiang Lei, Xin Wei, Ning Jiang, and Zhenglu Yang. "GMH: A General Multi-hop Reasoning Model for KG Completion." In Proceedings of the 2021 Conference on Empirical Methods in Natural Language Processing. Stroudsburg, PA, USA: Association for Computational Linguistics, 2021. http://dx.doi.org/10.18653/v1/2021.emnlp-main.276.

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Amprimo, Gianluca, Claudia Ferraris, Giulia Masi, Giuseppe Pettiti, and Lorenzo Priano. "GMH-D: Combining Google MediaPipe and RGB-Depth Cameras for Hand Motor Skills Remote Assessment." In 2022 IEEE International Conference on Digital Health (ICDH). IEEE, 2022. http://dx.doi.org/10.1109/icdh55609.2022.00029.

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Zhu, Yuchuan, and Xulei Yang. "Dynamical Model Research on Energy-Conversion Process of Giant Magnetstrictive Materials-Based Electrohydrostatic Actuator." In ASME/BATH 2015 Symposium on Fluid Power and Motion Control. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/fpmc2015-9559.

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A giant Magnetstrictive materials-based Electro-hydrostatic Actuator (MEHA) is shown by presenting its structure configuration and working principle, which include a Giant Material Actuator (GMA), pump, two one-way check valves, a cylinder and utilize fluid rectification via one-way check valves to amplify the small, high-frequency vibrations of GMA into large motions of a hydraulic cylinder. The established dynamic model of a MEHA involves five submodels from the viewpoint of energy conversion: the dynamic model of the power amplifier; the dynamic magnetization model that describes the relationship between the exciting current and the magnetization of the Giant Magnetostrictive Material (GMM) rod; the magnetoelastic model describing the relationship between the magnetostrictive strain and the magnetization of GMM rod; the kinetic model of the GMA describing the relationship between the GMA displacement (piston displacement of pump) and the magnetostrictive strain; the cylinder motion model. By the simulation to the above model, dynamic characteristics of MEHA are clearly exhibited by the dynamic response curves, which show a good agreement with the experimental data and gives a scientific explanation about the test results.
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Ti, Boyang, Yongsheng Gao, Qiang Li, and Jie Zhao. "Dynamic Movement Primitives for Movement Generation Using GMM-GMR Analytical Method." In 2019 IEEE 2nd International Conference on Information and Computer Technologies (ICICT). IEEE, 2019. http://dx.doi.org/10.1109/infoct.2019.8711390.

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Fang, Heng, Yang Chen, Wen-Jie Sun, Xian Lai, Jin-Xing Wei, Bo Yan, and Rui-Min Xu. "A Nonlinear GaN HEMT Modeling with the gm2 and gm3 Validation." In 2022 IEEE 16th International Conference on Solid-State & Integrated Circuit Technology (ICSICT). IEEE, 2022. http://dx.doi.org/10.1109/icsict55466.2022.9963163.

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Šmit, Biljana, Asija Halilagić, Enisa Selimović, Jelena Katanić Stanković, Nikola Srećković, and Tanja Soldatović. "STUDIES OF SUBSTITUTION REACTIONS WITH IMPORTANT BIOMOLECULES AND ANTIMICROBIAL ACTIVITY OF NOVEL ZN(II)-L-CU(II) COMPLEXES." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.328s.

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New dinuclear Zn(II)-L-Cu(II) complexes with different bridging ligands were synthesized. Interactions of these complexes with biologically important nucleophiles, 5′-GMP, 5′-IMP and GSH, were investigated by Uv-Vis spectrofotometric method. The distances between the metal ions lead to less reactivity of both centers due to reduced electronic communication between them and an increasing of electron density on the metal centers itself. Both complexes showed moderate antimicrobial activity against most of the tested bacterial and fungal strains.
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Meng, Aihua. "Design of Pulsed Jet On-Off Valve Based on Giant Magnetostrictive Actuator." In 2007 First International Conference on Integration and Commercialization of Micro and Nanosystems. ASMEDC, 2007. http://dx.doi.org/10.1115/mnc2007-21171.

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The pulsed jet device is a kind of device that can jet rapidly with micro flux. Present jet methods cannot fulfill the requirements of a large-flux, high-speed and stability in some applications. Combining with the character of pulsed jet device and the advantage of high-speed on-off valve, a new kind of micro-flux jet device —pulse jet on-off valve was designed. The basic structure and the working theory of the device were introduced first; then the valve was studied in detail on the basis of the requirements of jet speed and flux, including structure selection, rated pressure computation, dimension designing etc.. The advantages and disadvantages of actuators driven by electromagnetic, piezoelectric and giant magnetostrictive material (GMM) were compared, then GMM was chosen to drive the pulsed jet on-off valve. The flux and jet speed response experiments demonstrated that the pulsed jet on-off valve based on giant magnetostrictive actuator (GMA) could fulfill the requirements of application.
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Quiñonez Arce, José Ramón, Gordon E. Andrews, Alan D. Burns, and Naman Al-Dabbagh. "Grid Plate Flame Stabilizer for High Intensity Gas Turbine Combustion: The Influence of the Method of Fuel Injection on Mixing, Flame Development and NOx Emissions." In ASME Turbo Expo 2021: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/gt2021-60105.

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Abstract Grid plate flame stabilizers for low NOx emissions have renewed interest in recent years due to their use in low NOx hydrogen gas turbine combustors. For non-premixed grid plate combustion, the difference in flame stabilizer design is in how the grid plate air flow is fueled. In the present work a simple four hole grid plate is investigated using CFD with three methods of fueling the air holes: radially inward fuel injection using 8 fuel nozzles per air hole (Grid Mix, GM 1 and Micromix); central fuel injection (FLOX method); and through a fuel annulus around each air hole (GM2). ANSYS FLUENT CFD predictions for GM2 are compared with axial gas composition traverses inside the combustor and with the mean combustor exit plane emissions. The three methods of fuel injection are also compared using isothermal CFD to determine which of the three methods offer the best mixing quality, which controls the relative NOx emissions. The predictions were for an equivalence ratio of 0.624 for the combustion stage and 0.5 for the isothermal study, using industrial propane. CFD modelling used RANS simulation with Realizable k-epsilon turbulence model, non-premixed combustion with the Steady Laminar Flamelet model. The temperature and mixing profiles obtained for GM2 were in reasonable agreement with the experiments and the other two fuel injection methods were then compared with GM2.
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Zhang, Zheng, Chi-Un Lei, and Ngai Wong. "GHM." In the 2009 International Conference. New York, New York, USA: ACM Press, 2009. http://dx.doi.org/10.1145/1687399.1687541.

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Reports on the topic "GMH"

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Gunay, Selim, Fan Hu, Khalid Mosalam, Arpit Nema, Jose Restrepo, Adam Zsarnoczay, and Jack Baker. Blind Prediction of Shaking Table Tests of a New Bridge Bent Design. Pacific Earthquake Engineering Research Center, University of California, Berkeley, CA, November 2020. http://dx.doi.org/10.55461/svks9397.

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Considering the importance of the transportation network and bridge structures, the associated seismic design philosophy is shifting from the basic collapse prevention objective to maintaining functionality on the community scale in the aftermath of moderate to strong earthquakes (i.e., resiliency). In addition to performance, the associated construction philosophy is also being modernized, with the utilization of accelerated bridge construction (ABC) techniques to reduce impacts of construction work on traffic, society, economy, and on-site safety during construction. Recent years have seen several developments towards the design of low-damage bridges and ABC. According to the results of conducted tests, these systems have significant potential to achieve the intended community resiliency objectives. Taking advantage of such potential in the standard design and analysis processes requires proper modeling that adequately characterizes the behavior and response of these bridge systems. To evaluate the current practices and abilities of the structural engineering community to model this type of resiliency-oriented bridges, the Pacific Earthquake Engineering Research Center (PEER) organized a blind prediction contest of a two-column bridge bent consisting of columns with enhanced response characteristics achieved by a well-balanced contribution of self-centering, rocking, and energy dissipation. The parameters of this blind prediction competition are described in this report, and the predictions submitted by different teams are analyzed. In general, forces are predicted better than displacements. The post-tension bar forces and residual displacements are predicted with the best and least accuracy, respectively. Some of the predicted quantities are observed to have coefficient of variation (COV) values larger than 50%; however, in general, the scatter in the predictions amongst different teams is not significantly large. Applied ground motions (GM) in shaking table tests consisted of a series of naturally recorded earthquake acceleration signals, where GM1 is found to be the largest contributor to the displacement error for most of the teams, and GM7 is the largest contributor to the force (hence, the acceleration) error. The large contribution of GM1 to the displacement error is due to the elastic response in GM1 and the errors stemming from the incorrect estimation of the period and damping ratio. The contribution of GM7 to the force error is due to the errors in the estimation of the base-shear capacity. Several teams were able to predict forces and accelerations with only moderate bias. Displacements, however, were systematically underestimated by almost every team. This suggests that there is a general problem either in the assumptions made or the models used to simulate the response of this type of bridge bent with enhanced response characteristics. Predictions of the best-performing teams were consistently and substantially better than average in all response quantities. The engineering community would benefit from learning details of the approach of the best teams and the factors that caused the models of other teams to fail to produce similarly good results. Blind prediction contests provide: (1) very useful information regarding areas where current numerical models might be improved; and (2) quantitative data regarding the uncertainty of analytical models for use in performance-based earthquake engineering evaluations. Such blind prediction contests should be encouraged for other experimental research activities and are planned to be conducted annually by PEER.
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Harris, James, Kelly Lechtenberg, and Nikin Patel. GMS Configuration Guide. Office of Scientific and Technical Information (OSTI), December 2021. http://dx.doi.org/10.2172/1835245.

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Kolyovska, Vera, and Sonya Ivanova. Neurodegenerative Changes and Demyelination in Serum IgG Antibodies to GM1, GD1a and GM3 Gangliosides in Patients with Secondary Progressive Multiple Sclerosis – Preliminary Results. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, February 2019. http://dx.doi.org/10.7546/crabs.2019.01.15.

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Mate, Adam. The Carrington GMD project. Office of Scientific and Technical Information (OSTI), October 2019. http://dx.doi.org/10.2172/1571580.

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Clement, T. P., and N. L. Jones. RT3D tutorials for GMS users. Office of Scientific and Technical Information (OSTI), February 1998. http://dx.doi.org/10.2172/585058.

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Brown, Judith Alice, and Kevin Nicholas Long. Modeling the Effect of Glass Microballoon (GMB) Volume Fraction on Behavior of Sylgard/GMB Composites. Office of Scientific and Technical Information (OSTI), May 2017. http://dx.doi.org/10.2172/1367414.

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Shiihi, Solomon, U. G. Okafor, Zita Ekeocha, Stephen Robert Byrn, and Kari L. Clase. Improving the Outcome of GMP Inspections by Improving Proficiency of Inspectors through Consistent GMP Trainings. Purdue University, November 2021. http://dx.doi.org/10.5703/1288284317433.

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Approximately 90% of the pharmaceutical inspectors in a pharmacy practice regulatory agency in West Africa have not updated their training on Good Manufacturing Practice (GMP) inspection in at least eight years. However, in the last two years the inspectors relied on learning-on-the job skills. During this time, the agency introduced about 17% of its inspectors to hands-on GMP trainings. GMP is the part of quality assurance that ensures the production or manufacture of medicinal products is consistent in order to control the quality standards appropriate for their intended use as required by the specification of the product. Inspection reports on the Agency’s GMP inspection format in-between 2013 to 2019 across the six geopolitical zones in the country were reviewed retrospectively for gap analysis. Sampling was done in two phases. During the first phase sampling of reports was done by random selection, using a stratified sampling method. In the second phase, inspectors from the Regulatory Agency from different regions were contacted on phone to send in four reports each by email. For those that forwarded four reports, two, were selected. However for those who forwarded one or two, all were considered. Also, the Agency’s inspection format/checklist was compared with the World Health Organization (WHO) GMP checklist and the GMP practice observed. The purpose of this study was to evaluate the reporting skills and the ability of inspectors to interpret findings vis-à-vis their proficiency in inspection activities hence the efficiency of the system. Secondly, the study seeks to establish shortfalls or adequacies of the Agency’s checklist with the aim of reviewing and improving in-line with best global practices. It was observed that different inspectors have different styles and methods of writing reports from the same check-list/inspection format, leading to non-conformances. Interpretations of findings were found to be subjective. However, it was also observed that inspection reports from the few inspectors with the hands-on training in the last two year were more coherent. This indicates that pharmaceutical inspectors need to be trained regularly to increase their knowledge and skills in order to be kept on the same pace. It was also observed that there is a slight deviation in placing sub indicators under the GMP components in the Agency’s GMP inspection format, as compared to the WHO checklist.
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8

Woodroffe, Jesse R., and Lisa Marie Winter. Update on LANL GMD Research Tasks. Office of Scientific and Technical Information (OSTI), September 2018. http://dx.doi.org/10.2172/1469512.

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9

Zuehlke, A. C. GMS/DACS interface acceptance test report. Office of Scientific and Technical Information (OSTI), October 1994. http://dx.doi.org/10.2172/10192320.

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10

Ura, Karma, Sabina Alkire, Tshoki Zangmo, and Karma Wangdi. An Extensive Analysis of GNH Index. The Centre for Bhutan Studies, May 2012. http://dx.doi.org/10.35648/20.500.12413/11781/ii036.

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