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Dissertations / Theses on the topic 'GMP'

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1

Mantler, Mathias. "Der GMP-Vertrag aus bauvergaberechtlicher Sicht /." Frankfurt ; New York : Lang, 2004. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=010635104&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Dissertation Koln, Universität, 2003. Zugl.: Köln, Universiẗat, Diss., 2003 u. d. T.: Der GMP-Vertrag als neue Vertrags- und Wettbewerbsform aus bauvergaberechtlicher Sicht.<br>Includes bibliographical references (p. 187-204).
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2

Tang, Katherine Mary. "Targets of cyclic GMP in blood platelets, photolabelling, mutagenesis and pharmacological analysis of the cyclic GMP-inhibited phosphodiesterase." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0016/NQ30173.pdf.

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3

Engelhardt, Thomas. "The regulation of cyclic GMP during anaesthesia." Thesis, University of Aberdeen, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409272.

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The glutamate-NO-cyclic GMP pathway has previously been identified as a potential major target for general anaesthetic agents. An animal model of type I NOS gene disrupted mice was employed to investigate <i>in vivo </i>effects of the general anaesthetic agents isoflurane, ketamine, pentobarbital, and propofol on cyclic GMP in the presence or absence of the isoform specific NOS inhibitor, 7-nitroindazole. G protein function was studied <i>ex vivo </i>in whole brains. Primary neuronal cell cultures were employed to investigate the effects of anaesthetic agents on glutamate stimulated cyclic GMP
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4

Hennan, James Kenneth. "Role of cyclic GMP, cyclic GMP-dependent protein kinase and protein phosphorylation in the control of smooth muscle tension." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0017/NQ56558.pdf.

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Таран, О. І., та Олена Михайлівна Проскурня. "Реалізація нових вимог GMP на прикладі процесу "підготовка та отримання чистих середовищ" на фармацевтичному підприємстві"". Thesis, Національний фармацевтичний університет, 2015. http://repository.kpi.kharkov.ua/handle/KhPI-Press/25029.

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6

Schüler, Susanne. "Qualitätskontrolle von Blutkomponenten nach GMP ("Good Manufacturing Practice")." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=95979025X.

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7

Zolle, Lapuente Olga C. "Cyclic GMP and calcium homeostasis in endothelial cells." Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367654.

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8

Park, Ji S. "CYCLIC GMP: A SATIETY SIGNAL IN C. ELEGANS." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3851.

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Appetite control and satiety mechanisms help animals maintain energy homeostasis; however, these mechanisms can be misregulated, leading to overweight and obesity. Caenorhabditis elegans is an excellent model system to study appetite and satiety because of its conserved behavioral aspects of satiety and conserved molecular mechanisms. ASI senses nutrition and its activity is required for the behavioral state of satiety quiescence. The purpose of this thesis project was to elucidate the function of cGMP signaling in ASI by looking at behavioral effects from the pharmacological use of sildenafil
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Freedman, John. "Cyclic-di-GMP Signaling in the Borrelia Spirochetes." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/269.

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Lyme disease is the most common tick-borne disease in North America, with approximately 35,000 cases reported to the Centers for Disease Control in 2008. The genome of its causative agent, Borrelia burgdorferi, encodes for a set of genes involved in the metabolism and regulatory activities of the second messenger nucleotide, cyclic-di-GMP (c-di-GMP). Rrp1 is a response regulatory-diguanylate cyclase, and its regulatory capability is likely mediated via production of c-di-GMP, as it lacks a DNA-binding domain. One known class of c-di-GMP effector/binding proteins are those that harbor a PIlZ do
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10

Schüler, Susanne. "Qualitätskontrolle von Blutkomponenten nach GMP ("Good Manufacturing Practice")." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2000. http://dx.doi.org/10.18452/14490.

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Um die Qualität von Blutprodukten nach GMP zu überprüfen, wurden 72 Blutspenden bzw. ihre Folgeprodukte Erythrozytenkonzentrat in PAGGS-M, gefiltertes Erythrozytenkonzentrat und Fresh Frozen Plasma untersucht. Zusätzlich wurden an jeweils 12 Blutderivaten, die z.T. nicht zum Routineprogramm des Blutspendedienstes der Abteilung für Klinische Hämostaseologie und Transfusionsmedizin in Homburg/Saar gehören, Messungen durchgeführt, um ihre Qualität am Herstellungstag und am Ende der Haltbarkeit zu bestimmen. Als letztes wurden schließlich auch rheologische Parameter an 21 Erythrozytenkonzentraten
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11

Matsuyama, Bruno Yasui. "Caracterização estrutural e funcional de FleQ, fator de transcrição envolvido na expressão de genes flagelares e de formação de biofilme." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-02052016-111714/.

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Bactérias podem formar comunidades bacterianas sésseis, conhecidas como biofilmes, os quais possuem um grande impacto tanto na indústria, por serem responsáveis pelo entupimento e corrosão de tubulações, quanto na saúde, por serem resistentes ao tratamento com antibióticos. Nos últimos anos, o mensageiro secundário c-di-GMP foi descoberto como um importante regulador nas vias de sinalização envolvidas na capacidade da bactéria alternar entre esses dois fenótipos: livre nadante ou em biofilme. Um dos alvos moleculares de c-di-GMP é FleQ, uma Enhancer binding protein bacteriana (bEBP), que regul
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Torres, Naiara Utimura. "Estudo da ativação de biossíntese do polissacarídeo PEL na formação de biofilme de Pseudomonas aeruginosa PA14." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-18032016-155144/.

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Nos últimos anos, um estilo de vida celular vem ganhando destaque no mundo científico: o biofilme. O biofilme é uma comunidade celular em que as células permanecem aderidas a um substrato e envoltas em uma matriz de biopolímeros. Bactérias no estado de biofilme possuem algumas características alteradas, como o aumento da resistência a antibióticos e a facilidade de troca de genes de resistência, sendo um grande inconveniente na área médica e industrial. O patógeno humano Pseudomonas aeruginosa é uma bactéria gram-negativa causadora de infecções associadas a pacientes que apresentam o sistema i
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13

Dahinden, André Tony. "Umfassendes Qualitätsmanagement im GMP-Bereich unter Anwendung von Qualitätskosten." [S.l.] : [s.n.], 2003. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=15045.

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Dahinden, André Tony Dahinden André Tony. "Umfassendes Qualitätsmanagement im GMP-Bereich unter Anwendung von Qualitätskosten /." [S.l.] : [s.n.], 2003. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=15045.

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15

Simm, Roger. "Characterization of c-di-GMP signalling in Salmonella typhimurium /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-417-4/.

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16

Broderick, Kate Elizabeth. "Cyclic GMP - dependent signalling in D. melanogaster Malpighian tubules." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252518.

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17

Taibi, Fatima. "Études des riborégulateurs c-di-GMP chez Clostridium difficile." Mémoire, Université de Sherbrooke, 2016. http://hdl.handle.net/11143/8785.

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Chez une bactérie, la régulation de l’expression génétique est essentielle afin de maintenir l’équilibre, s’assurer du bon fonctionnement des processus cellulaires et mieux s’adapter aux changements environnementaux. Elle peut s’effectuer à plusieurs niveaux (la transcription, la traduction et la synthèse ou la dégradation des protéines), et par le bais de différents mécanismes, dont les protéines, font le plus grand part de cette régulation. Cependant, au début des années 2000, une découverte fascinante a mis en évidence un nouveau mécanisme de régulation dont l’ARN est l’acteur principal. Ce
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18

Tamaki, Gabriela Mól Avelar. "Estudo da sinalização por GMP cíclico em Blastocladiella emersonii." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-25032015-133924/.

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O segundo mensageiro cGMP está envolvido em diversas funções celulares incluindo a visão em mamíferos. Embora trabalhos anteriores mostrassem variações nos níveis de cGMP durante o ciclo de vida de Blastocladiela emersonii e evidências da existência de enzimas específicas envolvidas na sua síntese (guanilato ciclase) e degradação (cGMP fosfodiesterase), nenhum genoma de fungo publicado até o momento mostrou a existência de genes codificando estas enzimas. Este fato é atribuído por evolucionistas à completa perda de motilidade dos fungos em geral, já que cGMP está primordialmente associado a cé
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19

Deal, Justin. "Second Messenger Cyclic-di-GMP Regulation in Acinetobacter baumannii." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/honors/534.

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Over time, “superbugs,” or bacteria that have become resistant to antibiotics, have become a great concern in modern medicine. Viable alternates are currently being looked into as effective and safe ways to prevent or treat infections caused by these superbugs. One such method is through the utilization of the second messenger molecule cyclic-di-GMP (c-di-GMP) that has been shown to regulate phenotypes within other bacteria that may control surface colonization in Acinetobacter baumannii. Through a series of experiments, the active enzymes that create c-di-GMP - diguanylate cyclases - and brea
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20

Cook, Neil James. "Le gmp cyclique et la phototransduction chez les vertebres." Strasbourg 1, 1986. http://www.theses.fr/1986STR13147.

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Cook, Neil James. "Le GMP cyclique et la phototransduction chez les vertébrés." Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb375968043.

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22

Petruškevičiūtė, Erika. "Genetiškai modifikuotų organizmų gamybos ir naudojimo teisinis reguliavimas bei įtaka aplinkai ir visuomenei." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140603_111446-84625.

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Magistro baigiamajame darbe atskleista, kad daugelis respondentų yra neapsisprendę dėl savo pozicijos GMO gamybos bei naudojimo atžvilgiu, tačiau beveik trečdalis asmenų GMO gamybai bei naudojimui nepritaria. Dauguma gyventojų mano, kad GMO ne tik kenkia žmogaus sveikatai, bet ir yra pavojingi, taip pat kenkia aplinkai, o GMO turinčių produktų naudojimas gali negrįžtamai pakeisti genetinį žmogaus kodą ir augalų bei gyvūnų populiacijose gali sukelti negrįžtamus mutacinius pokyčius. Vis dėlto GMO produkciją kai kurie gyventojai linkę naudoti dėl mažesnės jų kainos ir ilgesnio vartojimo galiojimo
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23

Huang, Daming. "Molecular determinants of cGMP-binding to chicken cone photoreceptor phosphodiesterase /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/5095.

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Bau, Fernando Ricardo. "Avaliação do efeito relaxante do BAY 41-2272 em detrusor isolado de coelhos." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308919.

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Orientador: Edson Antunes<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-14T06:23:28Z (GMT). No. of bitstreams: 1 Bau_FernandoRicardo_M.pdf: 739046 bytes, checksum: e73f0e5383c7082e68c3cbf81bdfce5f (MD5) Previous issue date: 2009<br>Resumo: A síndrome da bexiga hiperativa atinge grande parte da população mundial, e gera sintomas que prejudicam a qualidade de vida dos portadores. Está associada com a hiperatividade do detrusor que se dá por um aumento das contrações espontâneas. Alguns estudos têm mostrado qu
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Alves, Moscoso Joana. "Regulatory cascades involving cyclic di-GMP signalling in Pseudomonas aeruginosa." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/24816.

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Cyclic di-GMP (c-di-GMP) has emerged as a bacterial second messenger that regulates a variety of cellular processes, in particular those associated with the switch between a motile and a sessile lifestyle. At low levels of c-di-GMP the motile lifestyle is favoured whereas at high levels of c-di-GMP the formation of biofilms is promoted. In Pseudomonas aeruginosa, over 50 genes encoding proteins involved in the synthesis, hydrolysis or sensing of c-di-GMP are found and many remain uncharacterized. Herein, an analysis of a collection of mutants was performed and supported the idea that the sophi
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Simonsson, Filip, Azucar Eduardo Cuadra, and Johan Roos. "Motivational Factors and their Prioritization for GMP in Nordic SMEs." Thesis, Internationella Handelshögskolan, Högskolan i Jönköping, IHH, Företagsekonomi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-39849.

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Purpose - The subject of green management and its connection to motivational factors is relatively unexplored in existing literature, especially regarding SMEs in the Nordic Countries. The paper aims to investigate frequencies of motivational factors as SMEs present them, suggest the theoretical prioritization of motivational factors for green management practices, and factors impact on different levels of green management. The reason for this is to help SMEs to better understand what motivational factors to prioritize to further their green management development.                          Des
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Günay-Esiyok, Özlem. "Cyclic GMP signaling during the lytic cycle of Toxoplasma gondii." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/20740.

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Der cGMP-Signalweg ist als einer der Hauptregulatoren von diversen Funktionen in Eukaryoten bekannt; allerdings ist seine Funktionsweise in Protozoen wenig verstanden. Im Rahmen dieser Arbeit wurde eine Guanylatcyclase, gekoppelt mit N-terminalen P4-ATPase, in intrazellulären Parasiten Toxoplasma gondii gemeldet. Eine in silico-Analyse wies auf eine Aktivierung der Guanylatcyclase durch Heterodimerisierung ihrer Cyclasedomänen hin und ermöglichte wertvolle Einsichten in mögliche Funktionen ihrer ATPase-Domäne. Dieses Protein (477-kDa) bezeichnet als TgATPaseP-GC in dieser Studie, lokalisiert i
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Goes, Júnior Francisco de Assis Mendes. "Relaxamento do corpo cavernoso de coelho induzido pela fração alcaloidal F3-5 de Aspidosperma ulei Markgr." reponame:Repositório Institucional da UFC, 2007. http://www.repositorio.ufc.br/handle/riufc/7320.

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GOES JÚNIOR, Francisco de Assis Mendes. Relaxamento do corpo cavernoso de coelho induzido pela fração alcaloidal F3-5 de Aspidosperma ulei Markgr. 2007. 65 f. Dissertação (Mestrado em Cirurgia) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2007.<br>Submitted by denise santos (denise.santos@ufc.br) on 2014-02-19T16:37:10Z No. of bitstreams: 1 2007_dis_famgoesjpunior.pdf: 1185630 bytes, checksum: bc50b6e04e8e3c6c6879faa44b04e3be (MD5)<br>Approved for entry into archive by denise santos(denise.santos@ufc.br) on 2014-02-19T16:38:19Z (GMT) No. of bitstreams: 1 2007_dis_famgoesj
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Diaz, Lucena Daniela Del Valle. "Mechanisms involved in the remyelinating effect of sildenafil." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/400468.

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Multiple Sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system characterized by a coordinated inflammatory attack on the myelin sheaths with ensuing damage to the underlying axons. Using myelin oligodendrocyte glycoprotein (MOG)-induced chronic experimental autoimmune encephalomyelitis (EAE) as a MS model, it has been previously demonstrated that daily administration of the PDE-5 inhibitor sildenafil starting at peak disease rapidly ameliorates clinical symptoms whereas administration at the onset of symptoms prevents disease progression. These beneficial e
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Bieliauskienė, Rūta. "Visuomenės informavimas ir žinių įvertinimas apie genetiškai modifikuotus produktus ir jų poveikį sveikatai." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2006. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2006~D_20060612_143049-66330.

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Introduction. Theme of modern biotechnologies is an especially topical question, because there is no simple answer about possible harm to nature and human health done by Genetically Modified Organisms (hereinafter referred to as GMO) until now. On the other side, biotechnology industry is a future industry, which provides great possibilities to improve the welfare of whole nations. Survey of Lithuanian public opinion shows that society thinks of GMO not very favorably and inhabitants treat those new products not well enough; with a great care and do not trust in their safety. Public institut
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Вабіщевич, Федір Федорович, Юрій Анатолійович Собко та О. О. Салій. "Впровадження вимог GMP на ТОВ «БіоТестЛаб» для забезпечення якості ветеринарних препаратів". Thesis, ЦП «Компринт», 2018. https://er.knutd.edu.ua/handle/123456789/11225.

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З метою реалізації стратегічного курсу України щодо Євроінтеграції Міністерство аграрної політики та продовольства України наказом № 606 від 10.11.2017 р. встановило єдиний для всієї території України режим правового регулювання для виробників ветеринарних препаратів за правилами та вимогами GMP. Біотехнологічні кампанії мають гарантувати та вдосконалювати якість ветеринарних препаратів шляхом регулярного перегляду методів виробництва та контролю якості, враховуючи і використовуючи наукові, технічні та програмні інновації галузі. Впровадження вимог GMP обов’язкове для виробництва ветеринарн
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Soares, José Roberto. "Desenvolvimento de sistema para seguimento de produto e aquisição de dados do processo de irradiação em irradiadores de grande porte." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-11082011-154344/.

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A esterilização utilizando a radiação ionizante é uma técnica consolidada para o processamento de produtos médicos descartáveis. No Brasil há irradiadores gama em operação com capacidade entre 0.37 PBq (10kCi) a 185 PBq (5 MCi ) utilizando radioisótopos 60Co como fonte de radiação. O trabalho desenvolvido proporciona um controle e registro apurado da aplicação das Boas Práticas de Fabricação (BPF), durante todas as fases de um processo de irradiação, requeridos pelas normas da ANVISA , ISO e recomendações técnicas da AIEA durante o tratamento de alimentos e produtos médicos. Todas as etapas en
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McLatchie, Linda. "Block of the cyclic GMP-activated conductance of salamander rod photoreceptors." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320405.

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Whiting, Nicola. "Characterisation of 'degenerate' cyclic di-GMP signalling proteins of Escherichia coli." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/7787/.

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Nold, Philipp [Verfasser]. "GMP-konforme Expansion und funktionelle Charakterisierung humaner mesenchymaler Stromazellen / Philipp Nold." Gießen : Universitätsbibliothek, 2017. http://d-nb.info/1149507276/34.

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Rescaldani, M. "RIDOTTA ATTIVITA' DEL SISTEMA OSSIDO NITRICO/GMP CICLICO PIASTRINICO NELL'IPERALDOSTERONISMO PRIMARIO." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/217624.

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Rationale: Nitric oxide (NO) exerts a vasodilating effect and inhibits platelet aggregation via the second messenger cyclic GMP (cGMP). Oxidative stress associated with hypertension and major cardiovascular risk factors inhibits NO/cGMP activity. Aldosterone (Aldo) exerts a potent pressor effect via its mineralocorticoid activity; moreover, Aldo increases oxidative stress and impairs endothelial NO availability in experimental and clinical conditions. Aim:To evaluate whether also platelet NO/cGMP activity is impaired by chronic Aldo excess, we compared platelet cGMP levels in patients with pr
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Gayou, Olivier. "Proton form factors : measurement of the proton form factors ratio µP GEp/GMp to Q2 = 5.6 GeV2 by recoil polarimetry." Clermont-Ferrand 2, 2002. http://www.theses.fr/2002CLF22343.

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Dans cette thèse sont présentés les résultats de l'expérience E99-007, qui a mesuré le rapport des facteurs de forme électrique et magnétique du proton, jusqu'au quadri-moment de transfert Q2 = 5. 6 GeV2, par polarisation de recul. Les données ont été prises en 2000 au Thomas Jefferson National Accelerator Facility en Virginie (USA). Un faisceau d'électrons polarisés de 4. 6 Gev a été diffusé sur une cible d'hydrogène liquide. La polarisation du proton de recul était mesurée dans le Polarimètre du Plan Focal, situé à l'extrémité de l'un des deux Spectromètres à Haute Résolution du Hall A. Le r
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Rosseto, Flávio Rodolfo. "Estudos estruturais e funcionais de STM3615 de Salmonella enterica: uma proteína contendo ambos os domínios GGDEF-EAL envolvidos na biossíntese de c-di-GMP." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-23032017-093752/.

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A formação de biofilmes bacterianos é um fenômeno bem conhecido, caracterizado pela formação de uma comunidade bacteriana estática, embebida em uma matriz exopolimérica, regulada pela molécula sinalizadora c-di-GMP. Os domínios proteicos que catalisam a síntese (GGDEF) e degradação (EAL e HD-GYP) de c-di-GMP estão presentes em grande quantidade em quase todos os genomas bacterianos sequenciados até hoje. Dentre as diversas proteínas envolvidas nas vias de sinalização mediadas por esse nucleotídeo, uma grande parcela são proteínas transmembranares que possuem ambos domínios GGDEF e EAL. Funcion
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QUIRIN, LAURENCE. "Gmp cyclique et hypertension arterielle gravidique : variations des taux plasmatiques et urinaires au cours du peri-partum." Université Louis Pasteur (Strasbourg) (1971-2008), 1993. http://www.theses.fr/1993STR1M054.

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Cerqueira, Joao Batista Gadelha de. "Identificação dos mecanismos envolvidos no relaxamento da musculatura lisa cavernosa e da aorta de coelho, induzido por doadores de óxido nítrico do complexo nitrosil-rutênio." reponame:Repositório Institucional da UFC, 2008. http://www.repositorio.ufc.br/handle/riufc/7710.

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CERQUEIRA, João Batista Gadelha de. Identificação dos mecanismos envolvidos no relaxamento da musculatura lisa cavernosa e da aorta de coelho, induzido por doadores de óxido nítrico do complexo nitrosil-rutênio. 2008. 125 f. Tese (Doutorado em Cirurgia) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2008.<br>Submitted by denise santos (denise.santos@ufc.br) on 2014-03-18T12:40:46Z No. of bitstreams: 1 2008_teses_jbgcerqueira.pdf: 1166899 bytes, checksum: 80812fd9e68a5a052d30380374a26a1a (MD5)<br>Approved for entry into archive by denise santos(denise.santos@ufc.br) on 2014
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Wu, Albert Ya-Po. "Molecular mechanism of cyclic nucleotide binding to the GAF domains of phosphodiesterases 2 and 5 /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/5012.

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Ryjenkov, Dmitri A. "Cyclic dimeric GMP, a novel bacterial second messenger enzymology of its turnover /." Laramie, Wyo. : University of Wyoming, 2006. http://proquest.umi.com/pqdweb?did=1188872151&sid=1&Fmt=2&clientId=18949&RQT=309&VName=PQD.

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Barnes, Christopher Simon. "The potential influence of cyclic GMP on arrhythmias associated with mycardial ischaemia." Thesis, University of Liverpool, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359292.

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Cancar, Dario, and Honghao Yu. "Layout design of a liquid packaging facility featuring GMP and Lean manufacturing." Thesis, KTH, Industriell produktion, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-183088.

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Seasol International Pty Ltd är ett australienskt företag som producerar ett sorts flytande organiskt gödsel. I nuläget är de marknadsledare inom flytande gödsel på den australienska marknaden. Därför vill Seasol nu i samarbete med Beijing JHM Commercial Trading Co., Ltd penetrera den kinesiska marknaden. En del av JHM:s plan för att uppnå detta mål är att bygga en ny fabrik i staden Tianjing. Fabriken ska användas för ompaketering av Seasols produkt till mindre behållare för försäljning. Målet med examensarbetet är således att utforma en planritning för ompaketeringsfabriken som kan möta JHM:
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Ganzella, Marcelo. "Efeito da administração de GMP sobre parâmetros comportamentais e neuroquímicos em camundongos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2007. http://hdl.handle.net/10183/13120.

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Várias evidências indicam que os derivados da guanina (nucleotídeos GTP, GDP, GMP e o nucleosídeo guanosina) são capazes, além de atuarem intracelularmente, de atuarem do lado externo da membrana plasmática celular, exercendo efeitos neuromoduladores no sistema nervoso central. Funções tróficas, mitóticas e até antiapoptóticas nas diferentes células neurais já foram descritas para alguns dos derivados, mas são os efeitos relacionados ao antagonismo do sistema glutamatérgico que parecem indicar um grande potencial terapêutico para os derivados da guanina. Os derivados da guanina, especialmente
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Gallagher, Thomas. "REGULATION OF SATIETY QUIESCENCE: CYCLIC GMP, TGF BETA, AND THE ASI NEURON." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3254.

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The worm Caenorhabditis elegans is a well-studied model organism in numerous aspects of its biology. This small free living nematode has less than 1,000 cells, but shows clear conservation in both signaling and behavior to mammals in aspects of appetite control. This is of importance to humans, where failure of appetite control is a major factor in the unprecedented obesity epidemic that we see today. In general, worm behavior reflects its internal nutritional state and the availability and quality of food. Specifically, worms show a behavioral state that mimics aspects of the mammalian beha
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Kostick, Jessica. "Characterization of cyclic-di-GMP signaling with the Lyme spirochete, Borrelia burgdorferi." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/272.

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Lyme disease is a tick-borne infection caused by Borrelia burgdorferi, B. garinii, and B. afzelii. These spirochetes experience environmental fluctuations as they are passed between mammalian and Ixodes tick hosts throughout their enzootic cycle. Recent studies have suggested cyclic diguanylate (c-di-GMP), a ubiquitous secondary messenger, is a key modulator of B. burgdorferi adaptive responses and may play a significant role in cycle progression. In this study, we examined the impact of the sole diguanylate cyclase (Rrp1), c-di-GMP binding proteins (PlzA and PlzB), and HD-GYP-containing phosp
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Gibbs, Sarah Margaretha. "Regulation of Drosophila visual system development by nitric oxide and cyclic GMP /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/10651.

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Allombert, Julie. "Rôles des voies de signalisation à di-GMP cyclique chez Legionella pneumophila." Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10161/document.

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Legionella pneumophila est une bactérie aquatique qui prolifère en se répliquant à l’intérieur de cellules amibiennes. Elle peut persister dans ces environnements en vivant en communauté sous forme de biofilms. L’inhalation par l’Homme d’eau contaminée, vaporisée par les réseaux d’eau chaude ou les tours aéro‐réfrigérantes, peut mener à l’infection des macrophages pulmonaires qui se traduit par une grave pneumonie appelée légionellose. Le di‐GMP cyclique (diGMPc) est impliqué, chez diverses espèces bactériennes, dans la transition entre les modes de vie mobiles et sessiles, et chez certains pa
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Gallagher, Thomas L. "Regulation of satiety quiescence| Cyclic GMP, TGF beta, and the ASI neuron." Thesis, Virginia Commonwealth University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3610909.

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<p> The worm <i>Caenorhabditis elegans</i> is a well-studied model organism in numerous aspects of its biology. This small free living nematode has less than 1,000 cells, but shows clear conservation in both signaling and behavior to mammals in aspects of appetite control. This is of importance to humans, where failure of appetite control is a major factor in the unprecedented obesity epidemic that we see today. </p><p> In general, worm behavior reflects its internal nutritional state and the availability and quality of food. Specifically, worms show a behavioral state that mimics aspects
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