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Journal articles on the topic 'GMP'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Bányai, Krisztián, Ágnes Bogdán, György Szücs, et al. "Assignment of the group A rotavirus NSP4 gene into genotypes using a hemi-nested multiplex PCR assay: a rapid and reproducible assay for strain surveillance studies." Journal of Medical Microbiology 58, no. 3 (2009): 303–11. http://dx.doi.org/10.1099/jmm.0.005124-0.

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The rotavirus non-structural protein NSP4 has been implicated in a number of biological functions during the rotavirus cellular cycle and pathogenesis, and has been addressed as a target for vaccine development. The NSP4 gene has been classified into six genotypes (A–F). A semi-nested triplex PCR was developed for genotyping the major human NSP4 genotypes (A–C), which are common in human rotavirus strains but are also shared among most mammalian rotavirus strains. A total of 192 previously characterized human strains representing numerous G and P type specificities (such as G1P[8], G1P[4], G2P

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2

Wadia, Reena. "Dental pain - GDP or GMP?" British Dental Journal 231, no. 8 (2021): 465. http://dx.doi.org/10.1038/s41415-021-3562-2.

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3

Cheng, Y. S., C. E. Patterson, and P. Staeheli. "Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP." Molecular and Cellular Biology 11, no. 9 (1991): 4717–25. http://dx.doi.org/10.1128/mcb.11.9.4717-4725.1991.

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The primary structures of interferon (IFN)-induced guanylate-binding proteins (GBPs) were deduced from cloned human and murine cDNAs. These proteins contained only two of the three sequence motifs typically found in GTP/GDP-binding proteins. The N(T)KXD motif, which is believed to confer guanine specificity in other nucleotide-binding proteins, was absent. Nevertheless, the IFN-induced GBPs exhibited a high degree of selectivity for binding to agarose-immobilized guanine nucleotides. An interesting feature of IFN-induced GBPs is that they strongly bound to GMP agarose in addition to GDP and GT

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4

Cheng, Y. S., C. E. Patterson, and P. Staeheli. "Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP." Molecular and Cellular Biology 11, no. 9 (1991): 4717–25. http://dx.doi.org/10.1128/mcb.11.9.4717.

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The primary structures of interferon (IFN)-induced guanylate-binding proteins (GBPs) were deduced from cloned human and murine cDNAs. These proteins contained only two of the three sequence motifs typically found in GTP/GDP-binding proteins. The N(T)KXD motif, which is believed to confer guanine specificity in other nucleotide-binding proteins, was absent. Nevertheless, the IFN-induced GBPs exhibited a high degree of selectivity for binding to agarose-immobilized guanine nucleotides. An interesting feature of IFN-induced GBPs is that they strongly bound to GMP agarose in addition to GDP and GT

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5

Dohong, Ita Susilawaty, Soaloon Sinaga, Betrixia Barbara, and Saputera Mardi. "Kajian Penerapan GHP (Good Handling Practices) dan GMP (Good Manufacturing Practices) Padi Terhadap Mutu Beras di Lokasi Penggilingan Padi Kawasan Food Estate Kabupaten Pulang Pisau." Jurnal Penelitian UPR 3, no. 2 (2023): 83–92. http://dx.doi.org/10.52850/jptupr.v3i2.11177.

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Beras merupakan bahan makanan pokok bagi sebagian besar masyarakat Indonesia. Seiring meningkatnya populasi penduduk, kebutuhan beras turut meningkat. Salah satu bentuk pemenuhan aspek kuantitas adalah peningkatan produksi di kawasan sentra padi sekaligus peningkatan mutu beras. Permasalahan mutu beras di antaranya adalah penerapan GHP (Good Handling Practices) dan GMP (Good Manufacturing Practices) di lokasi penggilingan padi. Penelitian ini bertujuan untuk mengkaji mutu beras yang dihasilkan penggilingan padi dan mengevaluasi tingkat kesesuaian penerapan GHP dan GMP di kawasan Food Estate ka

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6

Syahkhaafi, Mochammad Farrij Al, Delfi Gustina, Ferianto Ferianto, and Ekaterina Setyawati. "ANALISIS PENERAPAN GHP (GOOD HANDLING PRACTICE) DAN GMP (GOOD MILLING PRACTICE) PADA USAHA PENGGILINGAN PADI KECIL DI TAMBELANG, BEKASI." Seminar Nasional Pariwisata dan Kewirausahaan (SNPK) 1 (April 20, 2022): 391–400. http://dx.doi.org/10.36441/snpk.vol1.2022.62.

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Beras merupakan salah satu komoditas pangan yang sangat penting di Indonesia. Banyaknya eksistensi penggilingan padi di Indonesia membuat persaingan usaha penggilngan padi menjadi tinggi, sehingga mutu dan kualitas beras sangat menjadi acuan utama dalam usaha untuk memenangkan persaingan. Pemahaman terhadap standar mutu pengolahan beras harus dipahami khususnya bagi pelaksana usaha penggilingan padi, sehingga hasil produk lebih dapat bersaing di pasar. Tujuan dari penelitian ini adalah untuk melihat tingkat penerapan GHP dan GMP di penggilingan padi kecil (PPK X). Berdasarkan hasil rekapitulas

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7

Sarastuti, Sarastuti, Usman Ahmad, and Sutrisno Sutrisno. "Penerapan GHP dan GMP Pada Penanganan Pascapanen Padi Di Tingkat Penggilingan (GHP and GMP Implementations in Postharvest Handling of Rice at The Rice Mill Operator Level)." JURNAL PANGAN 27, no. 2 (2018): 79–96. http://dx.doi.org/10.33964/jp.v27i2.369.

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AbstrakPenerapan Good Handling Practices (GHP) dan Good Manufacturing Practices (GMP) pada penanganan pascapanen padi di tingkat penggilingan di Indonesia masih rendah, bahkan sebagian besar operator tidak memperhatikan tentang standar mutu beras. Penelitian ini bertujuan untuk mengevaluasi penerapan GHP dan GMP pada penanganan pascapanen padi di tingkat penggilingan. Survey dilakukan terhadap enam penggilingan padi penyalur beras mitra Toko Tani Indonesia Center dalam kegiatan Pengembangan Usaha Pangan Masyarakat (PUPM), di wilayah Jawa Barat. Pengumpulan data dilakukan melalui wawancara, obs

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8

Kfoury, Youmna, Fei Ji, Michael Mazzola, et al. "Niche Transfer of Small Non-Coding RNAs Regulates Hematopoietic Response to Stress." Blood 134, Supplement_1 (2019): 1207. http://dx.doi.org/10.1182/blood-2019-124794.

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The bone marrow (BM) niche, is an extrinsic regulator of hematopoietic stem and progenitor cells (HSPCs) (Morrison and Scadden 2014). The niche can drive disease and loss of HSPC function (Raaijmakers et al., 2010; Kode et al., 2014; Dong et al., 2016). Of particular interest, deletion in specific niche cells of the small RNA processing enzymes, Dicer1 and Angiogenin (Ang1) resulted in hematopoietic transformation (Raaijmakers et al., 2010) and loss of HSC quiescence (Goncalves et al., 2016), respectively. We tested mechanisms by which small non-coding RNAs (sncRNA) from niche cells might cont

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9

КУБДЖАНОВА, А. Ж., А. Р. ШОПАБАЕВА, and З. О. ЖАЛИМОВА. "ANALYSIS OF THE ACTIVITIES OF PHARMACY AND PHARMACEUTICAL MANUFACTURING ORGANIZATIONS IN THE WESTERN REGION OF THE REPUBLIC OF KAZAKHSTAN IN ACCORDANCE WITH THE REQUIREMENTS OF THE INTERNATIONAL STANDARD GPP AND GMP." Farmaciâ Kazahstana, no. 5 (December 14, 2021): 4–9. http://dx.doi.org/10.53511/pharmkaz.2021.58.76.001.

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В статье рассмотрено современное состояния деятельности аптечных и фармацевтических производственных организаций Западного региона Республики Казахстан в соответствии требованиями международного стандарта GPP и GMP. Приведены результаты социологического опроса аптек по переходу международному стандарту GPP в городе Актобе. The article considers the current state of activity of pharmacy and pharmaceutical manufacturing organizations in the Western region of the Republic of Kazakhstan in accordance with the requirements of the international standard GPP and GMP. The results of a sociological sur

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10

Hans-Jürgen, Wester. "GMP-Produktion." Nuklearmedizin - NuclearMedicine 51, no. 01 (2012): N1—N4. http://dx.doi.org/10.1055/s-0037-1621960.

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11

Li, Xiaojing, Jie Ye, Shoaib Munir, et al. "Biosynthetic Gene Pyramiding Leads to Ascorbate Accumulation with Enhanced Oxidative Stress Tolerance in Tomato." International Journal of Molecular Sciences 20, no. 7 (2019): 1558. http://dx.doi.org/10.3390/ijms20071558.

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Ascorbic acid (AsA) has high antioxidant activities, and its biosynthesis has been well studied by engineering of a single structural gene (SG) in staple crops, such as tomato (Solanum lycopersicum). However, engineering the AsA metabolic pathway by multi-SG for biofortification remains unclear. In this study, pyramiding transgenic lines including GDP-Mannose 3′,5′-epimerase (GME) × GDP-d-mannose pyrophosphorylase (GMP), GDP-l-Gal phosphorylase (GGP) × l-Gal-1-P phosphatase (GPP) and GME × GMP × GGP × GPP, were obtained by hybridization of four key genes to get over-expression transgenic plant

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12

Pena, Maria João, Raquel Costa, Ilda Rodrigues, et al. "Unveiling the Metabolic Effects of Glycomacropeptide." International Journal of Molecular Sciences 22, no. 18 (2021): 9731. http://dx.doi.org/10.3390/ijms22189731.

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For many years, the main nitrogen source for patients with phenylketonuria (PKU) was phenylalanine-free amino acid supplements. Recently, casein glycomacropeptide (GMP) supplements have been prescribed due to its functional and sensorial properties. Nevertheless, many doubts still persist about the metabolic effects of GMP compared to free amino acids (fAA) and intact proteins such as casein (CAS). We endeavour to compare, in rats, the metabolic effects of different nitrogen sources. Twenty-four male Wistar rats were fed equal energy density diets plus CAS (control, n = 8), fAA (n = 8) or GMP

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13

Dikshita, wagh* Jagruti G. Musale Dr Rishikesh S. Bachhav Dr. Smita S. Aher. "A Review On Quality Management System In Pharmaceutical Industry." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 394–403. https://doi.org/10.5281/zenodo.12671469.

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The quality management in pharmaceutical industry is important because of the quality of pharmaceutical product and drugs. QMS helps in pharmaceutical to improve the product quality and minimize the risk of product recall. product identity, purity, safety, and finally proper quality are extremely important or necessary.   Product quality maintenance is a difficult process that requires consideration of several regulations, including GMP, GLP, and many more. Every pharmaceutical industry has a quality assurance section whose responsibility it is to determine whether or not the industr

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14

Trofimova, E. O. "Transition to GMP standards." Remedium. Journal about the Russian market of medicines and medical equipment, no. 3 (2014): 25–27. http://dx.doi.org/10.21518/1561-5936-2014-3-25-27.

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15

He, Tian-Tian, Carolina Oi Lam Ung, Hao Hu, and Yi-Tao Wang. "Good manufacturing practice (GMP) regulation of herbal medicine in comparative research: China GMP, cGMP, WHO-GMP, PIC/S and EU-GMP." European Journal of Integrative Medicine 7, no. 1 (2015): 55–66. http://dx.doi.org/10.1016/j.eujim.2014.11.007.

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16

Gao, Xiaohui, Xiao Dong, Sundharraman Subramanian, et al. "Engineering of Bacillus subtilis Strains To Allow Rapid Characterization of Heterologous Diguanylate Cyclases and Phosphodiesterases." Applied and Environmental Microbiology 80, no. 19 (2014): 6167–74. http://dx.doi.org/10.1128/aem.01638-14.

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ABSTRACTMicrobial processes, including biofilm formation, motility, and virulence, are often regulated by changes in the available concentration of cyclic dimeric guanosine monophosphate (c-di-GMP). Generally, high c-di-GMP concentrations are correlated with decreased motility and increased biofilm formation and low c-di-GMP concentrations are correlated with an increase in motility and activation of virulence pathways. The study of c-di-GMP is complicated, however, by the fact that organisms often encode dozens of redundant enzymes that synthesize and hydrolyze c-di-GMP, diguanylate cyclases

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17

Roberge, Kristin. "Conducting portions of GLP studies in GMP laboratories." Quality Assurance Journal 8, no. 4 (2004): 253–57. http://dx.doi.org/10.1002/qaj.294.

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18

Gracia Anastasya, Taofik Rusdiana, and Ella Fazila. "Gap Analysis CPOB 2018 Terhadap Rancangan Revisi CPOB 2024 Aneks 1 Pembuatan Produk Steril Aspek Peralatan, Sarana Penunjang, dan Personalia." OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan 3, no. 2 (2025): 140–51. https://doi.org/10.61132/obat.v3i2.1136.

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The pharmaceutical industry operates under a strict regulatory framework to ensure that the products produced are safe, of high quality, and effective. These regulations are continuously updated to keep up with advancements in science, technological developments, and global demands for higher quality standards. The pharmaceutical industry also faces the challenge of global regulatory harmonization, such as standards set by WHO and PIC/S. These regulations are designed to ensure drug quality from development to distribution. Changes in Good Manufacturing Practices (GMP) regulations are crucial

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19

P, Sonu. "GMP A Vital Thread of Homoeopathy." International Journal of Science and Research (IJSR) 13, no. 11 (2024): 293–95. http://dx.doi.org/10.21275/sr241103194257.

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20

Blacutt, Jacob, Ziyang Lan, Elizabeth M. Cosgriff-Hernandez, and Vernita D. Gordon. "Quantitative confocal microscopy and calibration for measuring differences in cyclic-di-GMP signalling by bacteria on biomedical hydrogels." Royal Society Open Science 8, no. 1 (2021): 201453. http://dx.doi.org/10.1098/rsos.201453.

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The growth of bacterial biofilms on implanted medical devices causes harmful infections and device failure. Biofilm development initiates when bacteria attach to and sense a surface. For the common nosocomial pathogen Pseudomonas aeruginosa and many others, the transition to the biofilm phenotype is controlled by the intracellular signal and second messenger cyclic-di-GMP (c-di-GMP). It is not known how biomedical materials might be adjusted to impede c-di-GMP signalling, and there are few extant methods for conducting such studies. Here, we develop such a method. We allowed P. aeruginosa to a

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21

Sager, Georg. "Cyclic GMP transporters." Neurochemistry International 45, no. 6 (2004): 865–73. http://dx.doi.org/10.1016/j.neuint.2004.03.017.

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22

Pandita, Esha, Sudeepa Rajan, Safikur Rahman, Ranajoy Mullick, Saumitra Das, and Apurba Kumar Sau. "Tetrameric assembly of hGBP1 is crucial for both stimulated GMP formation and antiviral activity." Biochemical Journal 473, no. 12 (2016): 1745–57. http://dx.doi.org/10.1042/bcj20160220.

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hGBP1 has a unique characteristic that hydrolyses GTP to both GDP and GMP. A transition-state-induced tetramer of hGBP1 stimulates the activity through allosteric interactions leading to enhanced GMP formation and inhibition of hepatitis C virus (HCV) proliferation.

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23

Olsen, Wyatt, Ningjian Liang, and David C. Dallas. "Macrophage-Immunomodulatory Actions of Bovine Whey Protein Isolate, Glycomacropeptide, and Their In Vitro and In Vivo Digests." Nutrients 15, no. 23 (2023): 4942. http://dx.doi.org/10.3390/nu15234942.

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Whey protein isolate (WPI) consists of an array of proteins and peptides obtained as a byproduct of the cheesemaking process. Research suggests that WPI, along with its peptides such as glycomacropeptide (GMP), possesses immunomodulatory properties. These properties hold potential for alleviating the adverse effects of inflammatory conditions such as inflammatory bowel disease. Although promising, the immunoregulatory properties of the digested forms of WPI and GMP—those most likely to interact with the gut immune system—remain under-investigated. To address this knowledge gap, the current stu

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Baker, Amy E., Andreas Diepold, Sherry L. Kuchma, et al. "PilZ Domain Protein FlgZ Mediates Cyclic Di-GMP-Dependent Swarming Motility Control in Pseudomonas aeruginosa." Journal of Bacteriology 198, no. 13 (2016): 1837–46. http://dx.doi.org/10.1128/jb.00196-16.

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ABSTRACTThe second messenger cyclic diguanylate (c-di-GMP) is an important regulator of motility in many bacterial species. InPseudomonas aeruginosa, elevated levels of c-di-GMP promote biofilm formation and repress flagellum-driven swarming motility. The rotation ofP. aeruginosa's polar flagellum is controlled by two distinct stator complexes, MotAB, which cannot support swarming motility, and MotCD, which promotes swarming motility. Here we show that when c-di-GMP levels are elevated, swarming motility is repressed by the PilZ domain-containing protein FlgZ and by Pel polysaccharide producti

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Kuchma, S. L., N. J. Delalez, L. M. Filkins, E. A. Snavely, J. P. Armitage, and G. A. O'Toole. "Cyclic Di-GMP-Mediated Repression of Swarming Motility by Pseudomonas aeruginosa PA14 Requires the MotAB Stator." Journal of Bacteriology 197, no. 3 (2014): 420–30. http://dx.doi.org/10.1128/jb.02130-14.

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The second messenger cyclic diguanylate (c-di-GMP) plays a critical role in the regulation of motility. InPseudomonas aeruginosaPA14, c-di-GMP inversely controls biofilm formation and surface swarming motility, with high levels of this dinucleotide signal stimulating biofilm formation and repressing swarming.P. aeruginosaencodes two stator complexes, MotAB and MotCD, that participate in the function of its single polar flagellum. Here we show that the repression of swarming motility requires a functional MotAB stator complex. Mutating themotABgenes restores swarming motility to a strain with a

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26

Sakakibara, Toshihiro. "Introduction to GMP for investigational products." Folia Pharmacologica Japonica 139, no. 4 (2012): 170–73. http://dx.doi.org/10.1254/fpj.139.170.

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27

Srivastava, D., D. A. Fox, and R. L. Hurwitz. "Effects of magnesium on cyclic GMP hydrolysis by the bovine retinal rod cyclic GMP phosphodiesterase." Biochemical Journal 308, no. 2 (1995): 653–58. http://dx.doi.org/10.1042/bj3080653.

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Knowledge of the kinetics of the rod cyclic GMP phosphodiesterase is essential for understanding the kinetics and gain of the light response. Therefore, the interactions between Mg2+, cyclic GMP, and purified, trypsin-activated bovine rod cyclic GMP phosphodiesterase (EC 3.1.4.17) were examined. The effects of Mg2+ and of cyclic GMP on the rod phosphodiesterase activity were mutually concentration-dependent. Formation of a free Mg-cyclic GMP complex is unlikely due to its high dissociation constant (Kd = 19 mM). Plots of 1/velocity versus 1/[cyclic GMP] as a function of [Mg2+] and 1/velocity v

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28

Jamieson, Catriona, Mobin Karimi, Remi Creusot, et al. "Bioluminescent Imaging of Human Leukemic Stem Cell Engraftment." Blood 106, no. 11 (2005): 696. http://dx.doi.org/10.1182/blood.v106.11.696.696.

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Abstract Previously, we found that candidate leukemic stem cells (LSC) involved in chronic myelogenous leukemic (CML) progression to myeloid blast crisis (BC) shared phenotypic characteristics with granulocyte-macrophage progenitors (GMP). However, CML GMP had activated a key self-renewal gene - beta-catenin. Aberrant in vitro self-renewal capacity could be specifically inhibited with axin - a potent beta-catenin antagonist (Jamieson et al, New Engl J Med2004;351:657–67). In order to determine whether these candidate LSC had enhanced in vivo self-renewal potential, we FACS-sorted hematopoietic

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29

Chen, Hui-Jie, Na Li, Ye Luo, et al. "The GDP-switched GAF domain of DcpA modulates the concerted synthesis/hydrolysis of c-di-GMP in Mycobacterium smegmatis." Biochemical Journal 475, no. 7 (2018): 1295–308. http://dx.doi.org/10.1042/bcj20180079.

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The second messenger c-di-GMP [bis-(3′-5′)-cyclic dimeric guanosine monophosphate] plays a key role in bacterial growth, survival and pathogenesis, and thus its intracellular homeostasis should be finely maintained. Mycobacterium smegmatis encodes a GAF (mammalian cGMP-regulated phosphodiesterases, Anabaenaadenylyl cyclases and Escherichia coli transcription activator FhlA) domain containing bifunctional enzyme DcpA (diguanylate cyclase and phosphodiesterase A) that catalyzes the synthesis and hydrolysis of c-di-GMP. Here, we found that M. smegmatis DcpA catalyzes the hydrolysis of c-di-GMP at

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30

Olsson, Andre, Nathan Salomonis, Harinder Singh, and H. Leighton Grimes. "Identification of the Origin of Eosinophils." Blood 126, no. 23 (2015): 886. http://dx.doi.org/10.1182/blood.v126.23.886.886.

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Abstract Eosinophil granulocytes participate in parasite protection and also play a part in asthma and allergy. Histology staining shows a characteristic red granular stain, which separates the eosinophils from neutrophil and basophil granulocytes. Eosinophils can be characterized by SiglecF and CCL3 surface expression, and differentiate from bone-marrow CD34+ Granulocyte Monocyte Progenitors (GMP). Isolating GMP and stimulating with IL-3, GM-CSF and IL-5 leads to eosinophil colony forming units (CFU) in methylcellulose. Eosinophil precursors are currently are isolated by IL-5ra expression in

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Krivtsov, Andrei V., Matthew C. Stubbs, Renee Wright, Zhaohui Feng, Andrew L. Kung, and Scott A. Armstrong. "MLL-AF9 Initiates Leukemia from a Single Committed Hematopoietic Progenitor." Blood 108, no. 11 (2006): 2534. http://dx.doi.org/10.1182/blood.v108.11.2534.2534.

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Abstract Recent experiments have demonstrated that MLL-translocation associated fusion proteins can transform either hematopoietic stem cells (HSC) or granulocyte macrophage progenitors (GMP) into leukemia stem cells. However, it may be that leukemogenic process differs when HSC are the cell of origin as compared to myeloid progenitors. We transduced either HSC or GMP with a retrovirus expressing MLL-AF9 and GFP followed by single cell sorting of transduced cells. Approximately 80% of singly sorted MLL-AF9 transduced GMP (MLL-AF9-GMP) and about 25% of MLL-AF9 transduced HSC (MLL-AF9-HSC) could

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32

Arpi, Normalina, Tasya Eliza, and Yuliani Aisyah. "Penilaian Penerapan Good Manufacturing Practices (GMP) pada Proses Produksi Dimsum (Studi Kasus : UMKM XYZ)." Jurnal Teknologi dan Industri Pertanian Indonesia 16, no. 2 (2024): 183–89. http://dx.doi.org/10.17969/jtipi.v16i2.36351.

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Dimsum is a high-risk food category because it uses basic ingredients of chicken meat and these ingredients have a water content of around 65-80% and a high pH of around 6-7, as well as easily degraded and easy to grow microorganisms. This study aims to assess the application of GMP in the production process in Aceh Dimsum Micro, Small and Medium Enterprises (UMKM) and the application of GMP is the basic requirement for granting a distribution permit certificate for the Deep Food (MD) category by the Food and Drug Supervisory Agency (BPOM). In this study, the assessment of the application of G

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33

Hofer, Ursula. "GMP completes the cycle." Nature Reviews Microbiology 11, no. 9 (2013): 596. http://dx.doi.org/10.1038/nrmicro3103.

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34

THAYER, ANN M. "EUROPE ADOPTS GMP REGULATIONS." Chemical & Engineering News 84, no. 7 (2006): 29–33. http://dx.doi.org/10.1021/cen-v084n007.p029.

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35

Gildehaus, Franz. "Aufbau eines GMP-Radionuklidlabors." Der Nuklearmediziner 40, no. 04 (2017): 253–61. http://dx.doi.org/10.1055/s-0043-111356.

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ZusammenfassungMit der Änderung des Arzneimittelgesetzes 2009 erfolgte eine Neubewertung der Herstellung von Radiopharmaka. Seitdem unterliegt ihre Herstellung grundsätzlich dem Arzneimittelgesetz, wobei dies nicht nur für nicht-zugelassene Radiopharmaka gilt, sondern ebenso für die Herstellung von Tc-Kits aus zugelassenen Mo/Tc-Generatoren mithilfe von zugelassenen Markierungskits. Die für die Herstellung verantwortliche Person muss laut § 13 (1) entweder eine sachkundige Person sein, oder nach § 13 (2b) ein Arzt, der auch persönlich die Anwendung bei einem bestimmten Patienten vornimmt. Die

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36

Morris, J. "GMP compliant cold chain." Cryobiology 71, no. 3 (2015): 544–45. http://dx.doi.org/10.1016/j.cryobiol.2015.10.033.

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37

DeTora, David J. "GMP Compliance During Development." Drug Information Journal 33, no. 3 (1999): 769–76. http://dx.doi.org/10.1177/009286159903300316.

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38

Itoh, Roichi. "IMP-GMP 5′-nucleotidase." Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 105, no. 1 (1993): 13–19. http://dx.doi.org/10.1016/0305-0491(93)90163-y.

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39

Houslay, Miles D. "Renaissance for cyclic GMP?" Trends in Biochemical Sciences 10, no. 12 (1985): 465–66. http://dx.doi.org/10.1016/0968-0004(85)90199-9.

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40

Gandert, Etwina. "GMP‐konform und zukunftssicher." CITplus 28, no. 3 (2025): 40–41. https://doi.org/10.1002/citp.202500313.

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Okada, D. "Cyclic GMP binding regulates the catalytic activity of cyclic GMP-specific phosphodiesterase." Neuroscience Research 38 (2000): S48. http://dx.doi.org/10.1016/s0168-0102(00)81135-9.

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Zhang, Qihang, Michael Lazar, Lin Yan, et al. "Cyclic GMP Reduces Myocardial Stunning Through Non-Cyclic GMP Protein Kinase Mechanisms." Journal of Cardiovascular Pharmacology 44, no. 2 (2004): 235–43. http://dx.doi.org/10.1097/00005344-200408000-00014.

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Biswas, Kabir H., and Sandhya S. Visweswariah. "Distinct Allostery Induced in the Cyclic GMP-binding, Cyclic GMP-specific Phosphodiesterase (PDE5) by Cyclic GMP, Sildenafil, and Metal Ions." Journal of Biological Chemistry 286, no. 10 (2010): 8545–54. http://dx.doi.org/10.1074/jbc.m110.193185.

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Kuswardhani, Nita, Nidya Shara Mahardika, and Adine Rara Salsabila. "ANALISIS PENERAPAN GOOD MANUFACTURING PRACTICE (GMP) PADA PROSES PRODUKSI ROTI GEMBONG." Jurnal Penelitian Sains dan Teknologi Indonesia 3, no. 2 (2024): 357–68. https://doi.org/10.19184/jpsti.v3i2.1567.

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Perkembangan industri di Indonesia terus meningkat seiring dengan teknologi dan sistem produksi yang menunjang industri saat ini. Roti Gembong Hamasah merupakan salah satu perusahaan perseorangan yang bergerak di bidang pangan yaitu Roti Gembong. Evaluasi GMP mencakup 18 aspek seperti lokasi, bangunan, sanitasi, mesin, bahan, pengendalian proses, produk akhir, laboratorium, karyawan, pengemasan, label, penyimpanan, pemeliharaan, transportasi, dokumentasi, pelatihan, penarikan produk, dan penerapan pedoman. Analisis kesenjangan dengan metode gap analysis menunjukkan skor penerapan GMP sebesar 7

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Hossain, Muttaquina, Md Ahshanul Haque, Abu Syed Golam Faruque, Tahmeed Ahmed, Ulla Ashorn, and Per Ashorn. "Growth monitoring and promotion program services utilization patterns between home-based and facility-based delivery methods: A comparative analysis." PLOS One 20, no. 6 (2025): e0324918. https://doi.org/10.1371/journal.pone.0324918.

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Background In Bangladesh, utilization of government health facility-based growth monitoring and promotion (GMP) services is notably low, prompting non-governmental organizations (NGOs) to collaborate with the government to enhance GMP service utilization through home-based delivery. Despite this, there is limited information available on home-based GMP service utilization. This study aimed to investigate the utilization of GMP services between home-based and facility-based programs and identifying key factors and barriers to caregiver engagement with GMP services in rural Bangladesh. Methods A

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Orlov, V. A., and V. N. Shestakov. "Classification issues of GMP-inspection deficiencies: regulatory practices." Remedium Journal about the Russian market of medicines and medical equipment, no. 1-2 (2019): 48–54. http://dx.doi.org/10.21518/1561-5936-2019-1-2-48-54.

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Gildeeva, G. N., Yu V. Podpruzhnikov, and V. N. Shestakov. "Main errors of GMP inspections by the Russian inspectorate." Remedium Journal about the Russian market of medicines and medical equipment, no. 6 (2018): 46–49. http://dx.doi.org/10.21518/1561-5936-2018-6-46-49.

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Rushing, James W., Robert J. Dufault, Richard L. Hassell, and B. Merle Shepard. "IMPACT OF GAP AND GMP ON FEVERFEW PLANT MARKET-ABILITY." HortScience 40, no. 3 (2005): 894b—894. http://dx.doi.org/10.21273/hortsci.40.3.894b.

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Feverfew has aspirin-like properties and has been utilized for the treatment of pain, particularly migraine headache. Parthenolide is the sesquiterpene lactone believed to be responsible for the medicinal properties. The potential for utilizing existing tobacco production and handling systems for the production and postharvest handling of feverfew was investigated. In year one, 8 commercial tobacco growers each planted about one-half acre of feverfew (Tanacetum parthenium L. Schulz-Bip.). The yield of dry herb varied among farmers from about 122 to 772 (55 to 350 kg) pounds per half-acre. The

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Kojima, Seiji, Takuro Yoneda, Wakako Morimoto, and Michio Homma. "Effect of PlzD, a YcgR homologue of c-di-GMP-binding protein, on polar flagellar motility in Vibrio alginolyticus." Journal of Biochemistry 166, no. 1 (2019): 77–88. http://dx.doi.org/10.1093/jb/mvz014.

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AbstractYcgR, a cyclic diguanylate (c-di-GMP)-binding protein expressed in Escherichia coli, brakes flagellar rotation by binding to the motor in a c-di-GMP dependent manner and has been implicated in triggering biofilm formation. Vibrio alginolyticus has a single polar flagellum and encodes YcgR homologue, PlzD. When PlzD or PlzD-GFP was highly over-produced in nutrient-poor condition, the polar flagellar motility of V. alginolyticus was reduced. This inhibitory effect is c-di-GMP independent as mutants substituting putative c-di-GMP-binding residues retain the effect. Moderate over-expressio

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Yekti, Gema IA, and Yasmini Suryaningsih. "PENYULUHAN PRINSIP-PRINSIP GOOD MANUFACTURING PRACTICES (GMP) PADA HOME INDUSTRY OLAHAN SINGKONG DAN UBI DI DESA TOKELAN, KECAMATAN PANJI, KABUPATEN SITUBONDO." INTEGRITAS : Jurnal Pengabdian 3, no. 1 (2019): 55. http://dx.doi.org/10.36841/integritas.v3i1.361.

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Desa Tokelan merupakan salah satu desa yang ada di Kecamatan Panji yang memiliki beberapa home industry yang masih tradisional. Beberapa home industry yang masih tradisional yaitu home industry keripik singkong Jaya dan home industry Karang Mas Mbak Nur. Keduanya masih belum menerapkan prinsip-prinsip GMP dalam usahanya. Lingkungan produksi dari keduanya juga masih cenderung sederhana dengan memanfaatkan pekarangan rumah sebagai tempat produksi. Tata letak proses produksi pun tidak sesuai dengan prinsip GMP. Hal tersebut terjadi karena keterbatasan pengetahuan dan keterampilan mereka tentang p

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