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Dissertations / Theses on the topic 'God gene'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Schultz, Randy P. "An evaluation of praise music as a genre for incorporation into Lutheran worship." Online full text .pdf document, available to Fuller patrons only, 1999. http://www.tren.com.

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2

Almeida, Carina Marisa dos Santos. "Gold nanoparticle-DNA conjugates for oligonucleotide vectorization towards gene silencing." Master's thesis, Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10362/6212.

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Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina<br>The main objective of the work presented in this thesis was to develop a gene silencing system by taking advantage of the nanovectorization capability and optical properties of gold nanoparticles. The idea is based on the construction of a DNA structure containing a therapeutic oligonucleotide with the ability to form Hoogsteen hydrogen bonds with double-stranded DNA, producing a DNA triple helix, besides silencing the gene of interest. Hoogsteen bonds, more unstable than the conventional Watson-Crick bonds, pe

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3

Archer, Matthew D. "Proclaiming Christ: Thomas Aquinas and Karl Barth on Handing on the Word of God in Human Words." University of Dayton / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1468582662.

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4

Beck, Kimberly Jean. "Music as a delight of god and men : absolutism, genre, and instrumental music in seventeenth-century Salzburg." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/53925.

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The seventeenth century was an age of absolutist ideology during which many European princes took upon themselves trappings of both religious and secular authority. Composers in the service of absolutist patrons were compelled to provide music that could move easily between sacred and secular venues and represent both facets of the prince’s power. Contemporary conceptions of musical classification exhibit this porous threshold between religious and profane genres and performance spaces. In this dissertation, I show how a flexible conception of musical genre—one in which traditionally sacred an

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5

Wang, Shue. "Probing Single Cell Gene Expression in Tissue Morphogenesis and Angiogenesis." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/560919.

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The fascinating capability of cellular self-organization during tissue development and repair is a central question in developmental biology and regenerative medicine. Understanding the dynamic morphogenic and regenerative processes of biological tissues will have important implications in biology and medicine. Nevertheless, the elucidation of the cellular self-organization processes is hindered by a lack of effective tools for monitoring the spatiotemporal gene expression distribution and a lack of ability to perturb the self-organization processes in living cells and tissues. Multimodal mod

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6

Wilson, Paul Wayne II. "The Breakdown of Theodicy as a Cross-Genre Event in Post-Shoah Tragedy, Using the Framework of Ron Elisha's TWO." Miami University / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=miami1082928875.

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7

Brown, Iain. "Gene therapy for sporadic ovarian cancer." Thesis, University of Aberdeen, 2000. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602008.

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Ovarian cancer accounts for more deaths than all other gynaecological cancers taken together. The 5 year survival rate can be as high as 80% for cases diagnosed early, but the asymptomatic nature of the disease means that it is most frequently detected in the later stages. By this time, disease has invariably spread beyond the ovaries and the survival rate drops to around 30%. Treatment of ovarian cancer often fails due to a high rate of chemoresistance and novel methods of treatment and detection are required to increase the survival chances of patients. This study sought to determine whether

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Thomson, Andrew Montgomery. "Gene transfer in rumen Bacteroides species." Thesis, University of Aberdeen, 1990. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU497422.

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Obligately anaerobic bacteria of the genus Bacteroides are important and abundant inhabitants of the rumen and hind gut of mammals. They are the most numerous group in the rumen and play a major role in fibre degradation with the rumen. They are phylogenetically remote from the better studied groups of facultatively anaerobic gut bacteria (eg. enterobacteria), but are closely related to the colonic Bacteroides. Interstrain conjugal transfer of a plasmid, pRRI4 (coding for tetracycline (Tc) resistance), from the multiple plasmid bearing B.ruminicola strain 223/M2/7 to F101, a rifampicin resista

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9

Yuyan, Wang. "Chaozhou Daluogu: Performance, Repertoire, Instruments, Technique, Transmission and Sustainability in an Ancient Chinese Percussion Genre." Thesis, Griffith University, 2011. http://hdl.handle.net/10072/367857.

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Chaozhou daluogu a traditional art form involving percussion, wind and string instruments, which originated in the Chaoshan region, South China. The genre revolves around the dagu , the leading drum and conductor of the ensemble. Chaozhou daluogu is deeply embedded in the regional Chaoshan culture through its connection with what is usually referred to as the youshen (god pageant ceremony‘). From the legendary origins of the tradition – which its master performers trace back to the Tang dynasty – it is said to have kept original elements, but also undergone major change and development. Broad

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10

Lee, Philip R. "Gene regulation during morphogenesis in Candida albicans." Thesis, University of Aberdeen, 1998. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU531492.

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This thesis describes attempts to investigate the regulation of the Candida albicans hyphal-specific gene HYR1 by a functional dissection of the HYR1 promoter, protein localisation studies and analysis of HYR1 expression in C. albicans morphological mutants. Sequencing of the HYR1 promoter revealed several putative cis-acting elements within 700 bp of the determined HYR1 transcriptional start site. The possibility of using the LAC4 gene from Kluyveromyces lactis as a reporter for dissection of the HYR1 promoter in C. albicans was investigated. Expression of LAC4 in S. cerevisiae and C. albican

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11

Kluth, David Charles. "Glomerular gene transfer using genetically modified macrophages." Thesis, University of Aberdeen, 2001. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU534987.

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In this thesis I show that macrophages (both cell lines and primary cultures) can be transfected by recombinant adenoviruses expressing -galactosidase (A-gal/Av1Bng), that the macrophages become activated by the transfection process and can be easily manipulated to localise to inflamed glomeruli after direct injection into the renal artery of rats with an experimentally induced glomerular inflammation caused by nephrotoxic nephritis. The injection of transfected macrophages reduces the severity of injury in this model of glomerulonephritis as shown by a reduction in the degree of albuminuria.

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12

Palma, Matheus Mlot. "Desenvolvimento de nanopartículas metal-proteína para a entrega de DNA em estudos de terapia e vacinação gênicas." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/3/3137/tde-25102017-075918/.

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Um problema recorrente no desenvolvimento de vacinas de DNA e terapia gênica utilizando vetores não virais é a baixa eficiência de transfecção gênica. Isso ocorre devido às diversas barreiras físicas, enzimáticas e difusionais que o DNA precisa superar para chegar ao núcleo das células. Neste trabalho tem-se por objetivo o desenvolvimento de novos vetores não virais de entrega gênica, formados por DNA plasmidial (pDNA), proteínas (protamina ou T-Rp3) e nanopartículas de ouro (NPAu) na forma de complexos ternários. Para tal, NPAu\'s foram sintetizadas por redução com citrato de sódio, apresenta

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Tournu, Helene. "Global analyses of gene expression in Saccharomyces cerevisiae." Thesis, University of Aberdeen, 2001. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU535196.

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As part of the EUROFAN Transcript Consortium, northern analysis was used to study the expression of 200 yeast orphan genes. Five transient growth conditions were analysed, including glucose upshift, stationary phase, nitrogen starvation, osmotic shock, and heat shock. Around 72% of the genes analysed were expressed at low level, about 12% were expressed at a medium level, and 3.5% at a high level relative to the ACT1 mRNA. Almost half of the genes were regulated significantly in response to at least one of the growth conditions. Expression levels did not correlate with the Codon Adaptation Ind

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Wood, Rachel M. C. "Translational regulation of gene expression in Saccharomyces cerevisiae." Thesis, University of Aberdeen, 1994. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU540996.

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The over-expression of the Saccharomyces cerevisiae pyruvate kinase gene (PYK1) is limited at the level of transcription and translation (Moore et al, 1990a). High levels of PYK1 mRNA are not tolerated by the transformants which grow up to 5.2-fold slower than the untransformed host strain. In addition, the transformants are genetically unstable, reverting at high frequency to fast growing cells via plasmid loss (Moore et al., 1990c). A novel experimental system was designed to facilitate the analysis of the translational regulation of the PYK1 gene. This system had two components designed to

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Masson, Lindsey Fiona. "Diet-gene interactions in determining blood lipid concentrations." Thesis, University of Aberdeen, 2003. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU170761.

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Genetic variation may explain the heterogeneity in the lipid response to dietary change. A systematic literature review found 79 articles on dietary intervention studies, 14 articles on observational studies, and 22 reviews on diet-gene interactions. The evidence suggests that variation within the genes for apolipoprotein (apo) AI, AIV, B and E may influence the lipid response to dietary change. This study assessed the influence of six polymorphisms within the genes for apo B, apo E and lipoprotein lipase (LPL) on the association between habitual diet and lipid levels in 239 healthy men and wo

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Bermano, Giovanna. "The regulation of selenoprotein gene expression by selenium." Thesis, University of Aberdeen, 1996. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU089918.

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This thesis focuses on the influence of selenium supply on the expression of selenoproteins and possible mechanisms involved. It examines the effects of selenium on the expression of cytosolic glutathione peroxidase (cGSH-Px), phospholipid hydroperoxide glutathione peroxidase (PHGSH-Px) and type I iodothyronine 5'deiodinase (IDI) in liver, thyroid and heart of the rat. Nutritional studies in animals fed diets with different selenium content have shown that there is differential regulation of the three mRNAs and subsequent protein synthesis within and between organs, suggesting both that mechan

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Gibbons, Vaneesha Stewart. "Phenotypic switching in Candida albicans : a candidate gene approach." Thesis, University of Aberdeen, 1999. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU123578.

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This thesis describes the cloning and characterisation of two <I>Candida albicans</I> genes which were candidates for having a role in the phenotypic switching phenomenon of <I>C. albicans</I>. Phenotypic switching in <I>C. albicans</I> is a spontaneously occurring event whereby the surface morphology and several physiological processes of the <I>C. albicans</I> colony can change. These spontaneous switching events occur at high frequency and there are a range of up to fifteen different morphological forms that have been described. Switching is reversible and interconvertible (between the diff

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Iu, Yan Yu. "Enhancement of gene silencing effects of small interfering RNAs to N-methyld-D-asparate receptors by gold nonoparticiples." HKBU Institutional Repository, 2013. http://repository.hkbu.edu.hk/etd_ra/1552.

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Mann, William R. "Glucose-6-phosphate dehydrogenase : construction of yeast DNA libraries and screening for its gene." Thesis, University of Aberdeen, 1988. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU010105.

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The aim of the project was to determine the sequence of the gene encoding glucose-6-phosphate dehydrogenase (G6PDH) in the industrially used, but genetically little explored yeast Candida utilis. In the first strategy, a C. utilis DNA library was constructed in the expression vector phage lambda gt11, and was screened immunologically with antiserum raised against C. utilis G6PDH. The second strategy involved construction of libraries in the plasmid vector pTZ18R and screening with a mixed oligonucleotide probe. Two methods were developed that allow DNA, of appropriate quality for the construct

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20

McFadyen, Morag C. E. "Cytochrome P450 expression in normal and neoplastic human brain." Thesis, University of Aberdeen, 2000. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602047.

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Cytochrome P450 enzymes are a superfamily of constitutive and inducible haemoproteins, with a central role in the oxidative metabolism of a wide range of compounds. These enzymes have been shown to play important roles both in tumour development and mediation of chemotherapy. Although cytoclirome P450 was first identified in the liver, evidence has accumulated for the presence of cytochrome P450 in extrahepatic tissues including the brain. The presence of the xenobiotic metabolising cytochrome P450 enzymes in the brain is intriguing because of the possible ramifications on function from small

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21

Cooperman, Alison Fay. "Male Secondary Sexual Traits And Mating Behavior in the Species Drosophila Bipectinata Duda (Diptera: Drosophilidae)." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1155750119.

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22

Wilson, Paul Wayne. "The breakdown of theodicy as a cross-genre event in post-Shoah tragedy, using the framework of Ron Elisha's Two." Oxford, Ohio : Miami University, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=miami1082928875.

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23

Jacobsen, Mette Dorph. "Analysis of Candida albicans gene expression using single cell profiling." Thesis, University of Aberdeen, 2005. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU193586.

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Candida albicans is an important fungal pathogen of humans and shows great flexibility in adapting to diverse host niches, which present different ambient pH values, changes in O2 concentrations, various different substrates for metabolism and host defence mechanisms. Knowledge on how these environmental stimuli are sensed by the fungal cells is limited. Here, a bioinformatics approach was employed to search for putative receptors in the C. albicans genome. However, no obvious novel receptor candidates were identified that might function in environmental sensing in C. albicans. Using a GFP-bas

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Bertram, Gwyneth. "Structure and regulation of a Candida albicans alcohol dehydrogenase gene." Thesis, University of Aberdeen, 1994. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU068225.

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A cDNA encoding Candida albicans alcohol dehydrogenase was isolated from a C. albicans expression library constructed from mRNA from C. albicans growing under conditions favouring the hyphal form. The library was screened for sequences that encoded immunogenic proteins using sera from patients with oral candidosis. The corresponding gene was isolated from a C. albicans genomic library by colony hybridisation using the cDNA as a probe. The 5'-promoter region was identified and the CADH1 gene and promoter were sequenced. The coding sequence is 1,050 bp long and the CADH1 gene has strong homology

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Campbell, Jamie Iain. "Bacterial modulation of inflammatory gene expression in intestinal epithelial cells." Thesis, University of Aberdeen, 2001. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU534500.

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Commensal bacterial were screened for their ability to modulate inflammatory gene expression in epithelial cells. The influence of intestinal pathogens on cytokine responses was also investigated using co-culture models. It was demonstrated that Bacteroids thetaiotaomicron and Bacteroides vulgatus, which are both dominant members of the human colonic microflora, had the ability differentially to modulate inflammatory responses in intestinal epithelial cells. These observations were confirmed in vivo using a minimal flora rat model. The human pathogen Salmonella enteritidis, when incubated with

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Montgomery, Douglas S. "An investigation of rat DNA polymerase alpha." Thesis, University of Aberdeen, 1985. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU362670.

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The aim of this project was to clone the gene encoding the catalytic subunit of the rat DNA replication enzyme, DNA polymerase alpha. A strategy was adopted in which cDNA clones expressing the catalytic subunit sequences would be identified using anti-DNA polymerase antibodies. DNA polymerase alpha was partially purified from regenerating rat liver and exponentially growing rat Y3 myeloma cells. The catalytic subunit was identified as a 170-180kD polypeptide by activity gel analysis of partially purified Y3 cell fractions. The catalytic subunit was found to be susceptible to degradation but wi

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Ozcan, Numan. "Cloning and sequencing of a cellulase gene from Fibrobacter succinogenes SD35." Thesis, University of Aberdeen, 1992. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU546892.

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F.succinogenes is one of the most active bacteria of the rumen in growth-related degradation of recalcitrant forms of cellulose. The bacterium has multienzyme cellulase complex encoded by multiple genes to degrade crystalline cellulose. A genomic library of F.succinogenes SD35, constructed in the EMBL3, was screened for cellulolytic activity and 2.7kbp DNA fragment expressing a endoglucanase (SD-END-1) was further subcloned into pUC18 and expressed in E.coli DH5 alpha. DNA hybridisation (dot blot) experiments revealed that this gene (sd-end-1) is different from the endoglucanase encoding gene

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MODA, FABIO. "Engineered adeno associated-viruses expressing anti-prp molecules and polyelectrolyte gold nanoparticles as new therapeutic strategies for prion diseases in mouse models." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2010. http://hdl.handle.net/10281/19196.

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The prion diseases are neurodegenerative disorders of humans and animals that are sporadic or inherited in origin and can be transmitted. Despite remarkable differences in phenotypic expression, these disorders share a similar pathogenic mechanism, i.e. a posttranslational modification of the prion protein from a normal cellular isoform (PrPC) to insoluble and protease-resistant disease-specific species (termed PrPSc). PrPSc accumulates in the brain and, according to prion hypothesis, is responsible for the propagation of the pathologic process and transmissibility of the disease, by converti

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Schad, Julia. "Evolution of major histocompatibility complex genes in New World bats and their functional importance in parasite resistance and life-history decisions in the lesser bulldog bat (Noctilio albiventris)." Phd thesis, Universität Potsdam, 2012. http://opus.kobv.de/ubp/volltexte/2013/6351/.

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Immune genes of the major histocompatibility complex (MHC) constitute a central component of the adaptive immune system and play an essential role in parasite resistance and associated life-history strategies. In addition to pathogen-mediated selection also sexual selection mechanisms have been identified as the main drivers of the typically-observed high levels of polymorphism in functionally important parts of the MHC. The recognition of the individual MHC constitution is presumed to be mediated through olfactory cues. Indeed, MHC genes are in physical linkage with olfactory receptor genes a

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Gilbert, Rachel R. "Immunity and sexual signaling in the wolf spider Schizocosa ocreata." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1491561675682815.

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Laszewski, Henryk. "Transfert thermique photo-induit par des nanoparticules d’or appliqué à la thérapie génique." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLN003/document.

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La thérapie génique est probablement une des approches la plus ambitieuse de l'histoire de l'humanité pour éliminer des maladies résistantes à tout autre traitement. Cependant, c'est une approche qui doit encore être développée afin d'obtenir un meilleur contrôle du processus de délivrance des médicaments et aussi de réduire les coûts. À cette fin, ce projet de thèse est axé sur l’optimisation et le contrôle de la délivrance d’oligonucléotides basée sur l'utilisation de nanobâtonnets d'or (Gold NanoRods, GNRs). De telles nanoparticules (40 nm de long et 10 nm de diamètre) sont internalisées pa

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Carvalho, Ana de F. F. U. "Dietary kidney bean lectins affect insulin levels, change gene expression and modulate metabolism." Thesis, University of Aberdeen, 1992. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU049137.

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At high dietary concentrations kidney bean lectins severely impair the growth and health of animals by causing alterations both in local (gut) and systemic metabolism. This results in a switch to a catabolic state and to great loss of body reserves of lipid, glycogen and muscle protein. In the present work the potential role of hormones, in particular, insulin, in mediating some of the toxic effects of dietary kidney bean lectin was studied. The overall results indicated that: (a) Short- or long-term dietary exposure to kidney bean caused a severe reduction in circulating insulin concentration

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Wicksteed, Barton. "Use of gene fusions to study the expression of PYK1 in Saccharomyces cerevisiae." Thesis, University of Aberdeen, 1994. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU068131.

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This study examined the role of <I>PYKI </I>coding sequences in the expression of <I>PYK1::lacZ </I>gene fusions in <I>Saccharomyces cerevisiae. </I>Further aims were to examine the effects of the vector system upon the mRNA levels from these gene fusions the effect that these gene fusions have upon the yeast cell in general. Analysis of the <I>PYK1::lacZ </I>gene fusions revealed that <I>PYK1 </I>coding sequences were responsible for elevating mRNA levels. This elevation was not due to a single element within the coding region of the <I>PYK1 </I>gene as had been previously proposed (Purvis <I

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Nestor, Antoinette. "Physiological control of gene expression in adipose tissues of genetically obese (ob/ob) mice." Thesis, University of Aberdeen, 1994. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU068143.

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Fatty acids and glucose are fuels of major importance to mammalian tissues, and their uptake is controlled by two key proteins, lipoprotein lipase (LPL), and in insulin-sensitive tissues, the glucose transporter GLUT4. This thesis describes the investigation of these proteins at the level of the gene, in brown adipose tissue (BAT), white adipose tissue (WAT) and heart of lean and genetically obese (ob/ob) mice. In the first physiological study, energy expenditure was increased by acute exposure to cold, and it was found that in lean mice this resulted in an increase in LPL mRNA levels in BAT a

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Fouletier, Christine. "Angiotensin II receptor gene expression in freshly isolated and cultured rat proximal tubular cells." Thesis, University of Aberdeen, 2001. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU136917.

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The renin-angiotensin system (RAS) is a major physiological regulator of body fluid volume, electrolyte balance and blood pressure. The principal effector peptides for this system are the angiotensins, particularly angiotensin II (Ang II), whose biological cations are mediated by specific angiotensin receptors. The use of highly specific nonpeptide angiotensin antagonists has allowed identification and characterisation of two major Ang II receptor subtypes, designated AT1 and AT2. The aims of this thesis were to investigate AT1 and AT2 receptor expression at both mRNA and protein level in fres

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Cheung, John Kwok Shing. "Identifying candidate genes for ischaemic stroke." Thesis, University of Aberdeen, 2004. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU194105.

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Our approach in identifying candidate genes for ischaemic stroke involved the selection and genotyping of common polymorphisms of genes which may influence one of the major risk factors for stroke. Materials and Methods. DNA from Caucasian populations of control subjects and stroke patients was made available for PCR and subsequent genotyping, which included RFLP analysis, DASH and microsatellite analysis. Our chosen genes included the GNbeta3 gene (the C825T polymorphism), the p22PHOX gene the C242T and A640G polymorphisms) and the ERalpha gene (the PvuII, XbaI SNPs and TA dinucleotide tandem

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Pietrzak, Elżbieta. "Wpływ galaktooligosacharydów na modulację ekspresji genów związanych z układem immunologicznym ptaków i ryb." Rozprawa doktorska, Uniwersytet Technologiczno-Przyrodniczy w Bydgoszczy, 2020. http://dlibra.utp.edu.pl/Content/3212.

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Celem pracy było określenie wpływu galaktooligosacharydów GOS (oligosacharydów regulujących skład mikrobioty jelitowej oraz modulijącuch odpowiedź immunologiczną gospodarza) na modulację ekspresji genów związanych z układem immunologicznym ptaków i ryb. Wykazano, że stosowanie prebiotyku GOS w praktyce hodowlanej z wykorzystaniem metody in ovo lub jako dodatek paszowy, może przyczynić się do poprawy zdrowotności zwierząt w produkcji drobiarskiej oraz akwakulturze

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Hobson, Emma. "Functional analysis of a Sp1 binding site polymorphism in the collagen type α gene (COL1A1)". Thesis, University of Aberdeen, 2002. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU534432.

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The exact role of the COL1A1 first intron in gene transcription has not been characterized. To study its role in bone metabolism I examined a transgenic mouse with a targeted deletion of the col1A1 first intron (col-Int). I measured, by peripheral quantitative computed tomography, bone mineral density (BMD), geometry and predicted biomechanical properties in wild-type, heterozygous col-Int and homozygous col-Int mice. First intron deletion affected bone geometry independently of BMD. Homozygous col-Int bones had significantly reduced cross sectional area and bone mineral content compared with

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Porter, Ailsa. "Immediate early gene expression in the mesopontine tegmentum and midbrain after acute or chronic nicotine administration." Thesis, St Andrews, 2008. http://hdl.handle.net/10023/507.

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Pelliccia, M. "STRATEGIES FOR ENHANCING VIRAL GENE TRANSFER AND THE THERMOSTABILITY OF VIRAL VECTORS IN VACCINE APPLICATIONS." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/265518.

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At the most basic level viruses are biological nano-containers constituted by genetic material enclosed in a protein shell, capsid. A peculiar feature of viruses, both bacterial and some eukaryotic viruses, lies in the high packaging density of the genome in order to fit itself in the small capsid and hence the high internal osmotic pressure. Virus is a relatively stable particle equipped with fascinating mechanical properties of the capsid that are crucial for the virus lifecycle. Viruses have only one purpose: infect a host cell for reproducing themselves in order to generate new viral proge

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Paul-Carrière, Lisa. "Apprenance et Genre : Variations d'Apprenance et de Dépendance-Indépendance à l’égard du genre (DIG) dans des contextes d'écoles d'ingénieur-e-s : contribution à une théorie de l’apprenance." Thesis, Paris 10, 2016. http://www.theses.fr/2016PA100179.

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Notre thèse de doctorat présente trois études menées en 2011, qui croisent et distinguent le niveau d’apprenance, le sexe et le rapport aux normes du genre de 779 étudiant-e-s en école d’ingénieur-e-s, ceci afin d’évaluer les liens pouvant exister entre ces différentes variables ainsi que leurs effets en contexte d’apprentissage. Sous le postulat que les variations de l’apprenance ne sont pas aléatoires, et qu’existent en dehors des dispositions personnelles, des éléments externes liés aux contextes sociaux et qui ont des effets sur les attitudes des sujets vis-à-vis de l’apprentissage, nous a

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Russell, Charles Nivison. "Lux gene reporting of the interaction between Gaeumannomyces graminis and an antagonistic pseudomonad in the wheat rhizosphere." Thesis, University of Aberdeen, 1996. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU090353.

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In a series of short term, laboratory-based experiments, the interaction between Gaeumannomyces graminis var. tritici (Ggt) and the antagonist Pseudomonas corrugata lux in the wheat rhizosphere was studied. The pseudomonad had been chromosomally huxAB marked, providing luminescence as the basis of measurement. During initial in vitro characterisation of the interaction between the Ggt and P.corrugata hix, the antagonist was observed to luminesce more in areas of colonies nearest to the fungus, possibly suggesting that signalling had occurred. The phenomenon was shown to be dependent on spatial

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Whitehead, Jennifer L. "Molecular analysis of candidate genes in retinitis pigmentosa." Thesis, University of Aberdeen, 1996. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU090196.

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Retinitis pigmentosa (RP) is a clinically and genetically heterogeneous group of retinal degenerations which are one of the most common causes of inherited visual handicap. The aims of this study were three fold. Firstly, samples from 81 patients with RP and various other retinal degenerations were screened for mutations in four of the RP candidate genes (rhodopsin, ROM1 peripherin/RDS and CRBP1) by SSCP analysis followed by direct sequencing. Two heterozygous sequence changes, GCC299TCC (ala299ser) and G4084A, were identified in the rhodopsin gene, both of them in isolated cases of RP. Three

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ROSENBLATT, NATHALIE, and Francis Loor. "Le syndrome murin gld (generalized lymphoproliferative disease) (mutation d'un gene codant pour un ligand inducteur d'apoptose) : caracterisation de la lymphoproliferation et essais de correction du s." Université Louis Pasteur (Strasbourg) (1971-2008), 1994. http://www.theses.fr/1994STR13171.

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La mutation gld (generalized lymphoproliferative disease), affectant le gene codant pour le ligand de l'antigene fas, induit chez les souris mutees, une lymphoproliferation et un etat autoimmun. La lymphoproliferation des souris gld resulte de l'accumulation dans la rate et les ganglions, de cellules t, possedant un phenotype membranaire inhabituel, puisqu'elles expriment a la fois le marqueur des cellules t, thy1, et le marqueur des cellules b, b220. Une partie des travaux decrits dans cette these etait destinee a elucider l'etiologie de ce syndrome lymphoproliferatif. Ainsi, nous avons montr

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Delcourt, Matthieu. "The Quantitative Genetics of Good Genes: Fitness, Male Display, and Female Preference." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20311.

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The ultimate goal of my thesis is to develop a better understanding of the contribution of indirect benefits (i.e. good genes) to the evolution of female mate preferences. It is genetic variance in, and genetic correlations (covariances) among, male sexual displays, female preferences for them, and fitness that in part determine the degree to which females preferring certain male displays over others will gain an indirect benefit by having higher fitness offspring. Recent advances in quantitative genetic theory provide the mathematical means for quantifying the strength of indirect selection f

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Milner, Ben J. "The role of tumour suppressor genes in ovarian cancer." Thesis, University of Aberdeen, 1993. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU555006.

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The role of tumour suppressor genes, in particular p53 and DCC, was investigated in human ovarian cancer. p53 codes for a DNA-binding nuclear phosphoprotein whose expression, in the wild-type form, is essential in the control of the cell cycle. Loss of function of this gene by mutation allows unrestrained cell proliferation to occur. The function of the DCC gene is not yet fully understood. A total of 29 malignant epithelial ovarian tumours, 15 of borderline malignancy, and 12 benign tumours were collected for study. Allele loss analysis confirmed that deletion of the p53 and DCC genes had occ

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Nino-Vega, Gustavo Alexis. "Molecular analysis of chitin synthase genes of Paracoccidioides brasiliensis." Thesis, University of Aberdeen, 1996. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU601999.

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Two main characteristics make the fungal cell wall a good target for the development of antifungal antibiotics: its integrity is essential for the survival of the fungus, and it is mainly composed of polysaccharides which are not found in animal cells (Cabib et al., 1988). As chitin is the second major component in the cell wall of the pathogenic yeast form in P. brasiliensis and its content is almost three times higher than in the mycelial cell wall (Kanetsuna et al, 1969; San-Blas, 1985), its biosynthesis is an attractive target for the use of antifungal antibiotics against this medically im

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Dillahunt, Kyle D. "Frequency of PTEN Gene Mutations in Children with Autism Spectrum Disorder, Intellectual Disabilities, and Global Developmental Delays in the Presence of Macrocephaly." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1491991439195058.

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Lublin, Alex Louis. "The pumilio proteins PUF-5 and PUF-6/7/10 are necessary for repression of C. Elegans notch/glp-1 during late oogenesis (or not all that glitters is GLD-1) /." Connect to full text at ProQuest Digital Dissertations. IP filtered, 2005.

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Thesis (Ph.D. in Cell and Developmental Biology) -- University of Colorado at Denver and Health Sciences Center, 2005.<br>Typescript. Includes bibliographical references (leaves 82-86). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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Grant, Struan F. A. "Studies on genetic susceptibility to osteoporosis : analysis of cis-acting sequences in the collagen type I alpha 1 gene." Thesis, University of Aberdeen, 1995. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU543267.

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In osteogenesis imperfecta, an osteoporotic phenotype results from mutations in the protein coding regions of the collagen type I genes - COLIA1 and COLIA2. Genetic factors are known to play an important role in determining bone mass. For this reason, it was considered that more subtle mutations in the transcriptional control regions of the collagen type I genes might be associated with osteoporosis. The polymerase chain reaction was used, followed by single-stranded conformation polymorphism detection (PCR/SSCP) to screen for polymorphisms in the transcriptional control regions (the promoter

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