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1

Koutras, Demetrios. "Endemic Goiter - an update." HORMONES 1, no. 3 (2002): 157–64. http://dx.doi.org/10.14310/horm.2002.1163.

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2

Scrimshaw, N. S. "ENDEMIC GOITER." Nutrition Reviews 15, no. 6 (2009): 161–64. http://dx.doi.org/10.1111/j.1753-4887.1957.tb00524.x.

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3

Benitez, Rodrigo, Leslie Degroot, Mario Paredes, and Wilson Pañafiel. "Yodo, Bocio y Cretinismo endémicos en la región Andina del Ecuador." Revista Ecuatoriana de Medicina y Ciencias Biológicas 5, no. 1 (2017): 15–30. http://dx.doi.org/10.26807/remcb.v5i1.106.

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An inventory of the total population of isolated rural villages of the most affected Ecuadorian Andean provinces by endemic goiter was made. In each of these villages iodine content in urine, salt and water was determined. It was conclusive that the chronic iodine deficiency is sine qua non condition for the endemic; but the severity of the endemic; but the severity of the endemic doesn’t have relationship with the magnitude of the lack, rather due to the intercourse of socio-economic and biological intercurrent deficitary factors. Even with the iodine deficiency and the intercourse of the communities located more than 3,500 m, adove sea level, did not present goiter with endemic characteristics. The severity of the endemic was determined to be correlated with: incidence of nodular goiters, in the general population in the first two decades of life, presence of big goiters, incidence of goiters mean in the relation to that in woman. All of wich is epidemiologically related to the incidence of defects that would begin appearing in endemic form in a community, and in accord to the severity would follow the following order of appearing in the endemic form in a community, and in accord to the severity would follow the following order od appearance: motor abnormalities, mental deficiency, deafmutism, deafness and mutism. Finally, a familiar tendency was clearly demonstrated so that a cretin child would be born, and no relationship, on familial level, between incidence and type of goiter and the appearance.
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4

Cuevas-Ramos, Daniel, and Bernardo Pérez-Enríquez. "Endemic Multinodular Goiter." New England Journal of Medicine 356, no. 26 (2007): e27. http://dx.doi.org/10.1056/nejmicm065299.

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5

Naramore, Sarah E. "Making Endemic Goiter an American Disease, 1800-1820." Journal of the History of Medicine and Allied Sciences 76, no. 3 (2021): 239–63. http://dx.doi.org/10.1093/jhmas/jrab018.

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Abstract In 1800, American physician and naturalist Benjamin Smith Barton (1766-1815) published A Memoir Concerning the Disease of Goitre as it Prevails in Different Parts of North-America. The text documented the nature of the disease in the United States and highlighted how it differed from the ailment’s presentation in European patients. While medical topographies were common during this period, Barton’s goiter research and the steady stream of American goiter research that followed are worth special attention. This body of literature demonstrates how American physicians understood their relationship to transnational medical discussions and the unique perspective they brought to them. Goiter literature was common in European medical and travel writing during this period and intensely focused on the appearance of the disease in the mountains of Switzerland and Northern Italy. American goiter by its very appearance in non-mountainous regions of the United States contradicted nearly all of the received wisdom about the ailment’s cause and potential cure. For two decades, American writers leveraged their own observations and local knowledge to challenge larger narratives in their field.
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6

Gaitan, Eduardo, Norman C. Nelson, and Galen V. Poole. "Endemic goiter and endemic thyroid disorders." World Journal of Surgery 15, no. 2 (1991): 205–15. http://dx.doi.org/10.1007/bf01659054.

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7

Sauiin, Clark T. "Goiter and Endemic Cretinism." Endocrinologist 9, no. 3 (1999): 157–58. http://dx.doi.org/10.1097/00019616-199905000-00001.

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8

CORVILAIN, B., J. VAN SANDE, J. E. DUMONT, P. BOURDOUX, and A. M. ERMANS. "Autonomy in Endemic Goiter." Thyroid 8, no. 1 (1998): 107–13. http://dx.doi.org/10.1089/thy.1998.8.107.

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9

Fernando, Ranil, Pramodh Chandrasinghe, Sumal Nandasena, and Arunasalam Pathmeswaran. "Epidemiology of Goiters in Sri Lanka with Geographic Information System Mapping: Population-based Cross-sectional Study." World Journal of Endocrine Surgery 7, no. 3 (2015): 55–59. http://dx.doi.org/10.5005/jp-journals-10002-1170.

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ABSTRACT Background Sri Lanka is considered an endemic region for goiter. Early researchers have suggested the existence of a goiter belt based on rainfall pattern. Subsequent studies done in school children have challenged this theory. Current study is a community-based cross-sectional study done to assess the epidemiology of goiters. Geographic information system (GIS) mapping of the goiter prevalence is developed for the first time in Sri Lanka. Methods Study subjects were selected using a multi-staged cluster sampling with probability proportionate to size (PPS) method. Examination for the presence of goiters was done by two trained investigators and graded. ArcGIS 10 software was used for geostatistical analysis and developing a map by interpolating the data collected for the first time in Sri Lanka. Results A total of 5200 individuals (female—66%, median age—38 years; range 10–92 years) were assessed and 426 goiters were detected. The adjusted prevalence rate of goiters was 6.8%. Kriging interpolation method was used to develop the most appropriate epidemiological map clustering of high prevalence areas with scattered pockets of high prevalence was observed. Current map does not show a prevalence pattern in relation to the rainfall or elevation above sea level as proposed in the past. Conclusion Goiter prevalence in Sri Lanka appears to be different from earlier proposed patterns. Use of GIS has contributed to develop a comprehensive epidemiological map of goiters demonstrating the absence of an endemic goiter belt in the wet zone as proposed earlier. How to cite this article Chandrasinghe P, Fernando R, Nandasena S, Pathmeswaran A. Epidemiology of Goiters in Sri Lanka with Geographic Information System Mapping: Population-based Cross-sectional study. World J Endoc Surg 2015;7(3):55-59.
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10

Volodchenko, N. P., N. V. Valova, V. V. Ishchenko, S. V. Kravtsova, E. A. Shevcheko, and T. K. Ishchenko. "RESULTS OF SURGICAL TREATMENT OF NODULAR GOITER IN THE REGION OF ENDEMIC GOITER." Amur Medical Journal, no. 3 (2017): 79–80. http://dx.doi.org/10.22448/amj.2017.3.79-80.

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11

Dewi, Yulia Lanti Retno, Budiyanti Wiboworini, Widardo Widardo, Amelya Augusthina, and Dwi Rahayu. "Pengaruh Faktor Biologis dan Sosial Ekonomi Terhadap Kejadian Gondok di Kismantoro Wonogiri." MEDIA KESEHATAN MASYARAKAT INDONESIA 20, no. 3 (2021): 159–62. http://dx.doi.org/10.14710/mkmi.20.3.159-162.

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Latar Belakang: Gondok merupakan masalah kesehatan masyarakat di Indonesia. Kecamatan Kismantoro kabupaten Wonogiri merupakan salah satu daerah endemik kekurangan iodium dan telah diketahui lebih dari setengah abad yang lalu. Penelitian ini bertujuan untuk menganalisis pengaruh faktor biologis dan sosial ekonomi terhadap kejadian gondok di Kismantoro, Wonogiri.Metode: Penelitian ini adalah penelitian observasional analitik dengan rancangan kasus kontrol. Data dikumpulkan dengan kuesioner pada orang yang telah diketahui menderita gondok dan tidak sebagai kontrol. Data yang diambil meliputi faktor biologis dan sosial ekonomi. Jumlah subjek penelitian sebanyak 38 orang .Hasil : Penderita gondok sebanyak 55.3%, umur terbanyak diatas 50 tahun 57.9%, jenis kelamin perempuan sebanyak 86.8%, riwayat gondok dalam keluarga 23.7%, pendidikan rendah 73.7%, pekerjaan sebagai petani 60.5% dan pendapatan rendah 63.2%. Uji Fisher menunjukkan perbedaan yang signifikan (p<0.001).Simpulan: Faktor biologis dan faktor sosial ekonomi mempengaruhi kejadian gondok di Kismantoro.Kata kunci: gondok, Kismantoro, Wonogiri, faktor biologis, faktor sosial ekonomiABSTRACTTitle: The Influence of Biological and Socioeconomic Factors on The Event Of Endemic Goiter In Kismantoro, Wonogiri Background: Endemic goiter is a public health problem in Indonesia. Kismantoro sub-district, Wonogiri at Central Java is one of these endemic area. It has been known for a long time, around five decades. This study was aimed at analyzing the influence of biological and socioeconomic factors on the event of endemic goiter.Method: The study is an observational analytic with case control design.A specially designed questionnaires was used to collect the data. Data on biological socioeconomic factors were taken from 38 subjects.Result: Subjects with goiter 55.3 %, 57.9% of subjects with goiter aged >50 y, and 86.8% are females, 23.7% have history of endemic goiter in their families, working as farmer 60.5%, lower education in 73.7%, and lower incomes in 63.2%. Fisher test showed significant result (p<0.001)Conclusion: Biological and socioeconomic factors aggravate endemic goiter in Kismantoro , Wonogiri. Keywords: goiter, Kismantoro, Wonogiri, biological factor, socioeconomic factor
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12

Niculescu, D. "Endemic Goiter from the Carpathians." Acta Endocrinologica (Bucharest) 9, no. 4 (2013): 645–46. http://dx.doi.org/10.4183/aeb.2013.645.

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13

Costa, A., V. Benedetto, C. Ricci, et al. "Immunological features of endemic goiter." Clinical Immunology and Immunopathology 41, no. 2 (1986): 265–72. http://dx.doi.org/10.1016/0090-1229(86)90110-8.

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14

Kasatkina, E. P., D. E. Shilin, G. V. Ibragimova, et al. "Analysis of current recommendations and criteria of the world health organization for the assessment of iodine deficiency conditions." Problems of Endocrinology 43, no. 4 (1997): 3–6. http://dx.doi.org/10.14341/probl19974343-6.

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The incidence of endemic goiter in the Orel district of Russia has been studied in order to assess the informative value of the new WHO classification for identification of iodine deficiencies (1994). A total of 2103 children living in three rural regions, two of which were polluted with low-dose radiation after the Chernobyl accident, have been examined in 1992-1996. The incidence of goiter and thyroid dysfunction in the newborns corresponded to grave endemia, and the median of blood thyroglobulin was moderately increased in the region with the highest pollution (5 to 15 Ci/km2 for 127Cs), characterized by a slight iodine deficiency. In a less contaminated region (1 to 5 Ci/km2) with a similar level of iodine deficiency, incidence of goiter, and median of blood thyroglobulin the incidence of thyroid dysfunction in the newborns was moderate. In a pure region, despite a more evident iodine deficit and a compatible increase of the median of blood thyroglobulin, the incidence of endemic goiter and thyroid dysfunction of the newborns was the minimal. Hence, the values of the analyzed iodine deficit indicators did not correlate with the actual iodine deficiency in all the regions examined. These differences suggest a possible contribution of strumogenic factors other than iodine deficit to the formation of goiter endemia in the examined district. The detection of these factors in the environment is needed for objective evaluation of the causes and severity of the endemic process and for the development of differentiated approaches to the prevention and treatment of thyroid abnormalities in the population exposed to radiation.
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15

Mutalazimah, Mutalazimah, Budi Mulyono, Bhisma Murti, and Saifuddin Azwar. "Asupan Yodium, Ekskresi Yodium Urine, dan Goiter pada Wanita Usia Subur di Daerah Endemis Defisiensi Yodium." Kesmas: National Public Health Journal 8, no. 3 (2013): 139. http://dx.doi.org/10.21109/kesmas.v8i3.359.

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Rendahnya asupan yodium berhubungan dengan ekskresi yodium urine (EYU) yang tidak normal. Asupan yodium yang terlalu rendah juga menyebabkan kelenjar tiroid tidak mampu mempertahankan sekresi hormon yang adekuat sehingga timbul hipertrofi tiroid yang menimbulkan goiter. Penelitian ini bertujuan menguji hubungan asupan yodium, EYU, dan goiter pada wanita usia subur (WUS) di daerah endemis defisiensi yodium. Penelitian observasional potong lintang ini dilakukan pada 115 WUS di Kecamatan Prambanan Sleman yang dipilih secara random. Asupan yodium diukur menggunakan metode food recall 24 jam, EYU diukur dengan metode acid digestion, dan goiter diukur dengan cara palpasi. Hubungan antarvariabel dianalisis dengan uji kai kuadrat. Hasil penelitian menunjukkan subjek dengan asupan yodium kurang sebanyak 83,5% dan asupan yodium cukup sebanyak 16,5%. Subjek dengan goiter sebanyak 13% dan tanpa goiter sebanyak 87%. Subjek defisiensi yodium sebanyak 15,7% (tingkat berat 2,6%; tingkat sedang 3,5%; tingkat ringan 9,6%), yang normal sebanyak 31,3%, sedangkan yang lebih sebanyak 20,8% dan ekses sebanyak 32,2%. Asupan yodium berhubungan dengan EYU, tetapi goiter tidak berhubungan dengan asupan yodium dan EYU.The low iodine intake, associated with insufficiency of urinary iodine concentration (UIC). Iodine intake is too low, also causes the thyroid gland is unable to maintain adequate hormone secretion, influence the thyroid hypertrophy that causes goitre. This study aimed to examine the relationship of iodine intake, UIC, and goiter on women of childbearing age in endemic areas of iodine deficiency. This cross-sectional observational study was performed 115 randomly selected women of childbearing age at sub-district of Prambanan, Sleman Regency. Iodine intake was measured using 24-hour food recall method, UIC measured by acid digestion method, and goiter measured by palpation method.The association between variables
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16

Leporsky, V. N. "On the characteristics of endemic goiter in the Gorky region." Kazan medical journal 43, no. 3 (2021): 74–75. http://dx.doi.org/10.17816/kazmj83965.

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At the 22nd All-Union Congress of Surgeons, V.S. Levit, in his keynote speech, highlighting the distribution of endemic goiter in the Soviet Union, noted that goiter occurs in the Nizhny Novgorod Territory in the region of Murom and Kovrov. Before the Great October Revolution, the issues of endemic goiter in the Nizhny Novgorod province were not studied
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17

Kasatkina, E. P., L. A. Lisenkova, L. A. Scheplyagina, et al. "Prevalence of somatic diseases in children with endemic goiter." Problems of Endocrinology 40, no. 4 (1994): 14–16. http://dx.doi.org/10.14341/probl12133.

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A total of 1649 children aged 0 to 16 years were examined in the Khvalynsk district of the Saratov region endemic for goiter. Age-specific features of prevalence of goiter and chronic somatic diseases were studied. Goiter was found to form starting from the first years of life, with its morbidity peaks observed at the age of 3, 5, 7, and 12. Disease incidence in children with endemic goiter was found to be higher than in those without thyroid abnomalities.
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18

Neumann, Susanne, Helmut Willgerodt, Frank Ackermann, et al. "Linkage of Familial Euthyroid Goiter to the Multinodular Goiter-1 Locus and Exclusion of the Candidate Genes Thyroglobulin, Thyroperoxidase, and Na+/I− Symporter*." Journal of Clinical Endocrinology & Metabolism 84, no. 10 (1999): 3750–56. http://dx.doi.org/10.1210/jcem.84.10.6023.

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Abstract Iodine deficiency is the most important etiological factor for euthyroid endemic goiter. However, family and twin pair studies also indicate a genetic predisposition for euthyroid simple goiter. In hypothyroid goiters several molecular defects in the thyroglobulin (TG), thyroperoxidase (TPO), and Na+/I− symporter (NIS) genes have been identified. The TSH receptor with its central role for thyroid function and growth is also a strong candidate gene. Therefore, we investigated a proposita with a relapsing euthyroid goiter and her family, in which several members underwent thyroidectomy for euthyroid goiter. Sequence analysis of the complementary DNA (cDNA) of the TPO and TSH receptor genes revealed several previously reported polymorphisms. As it is not possible to exclude a functional relevance for all polymorphisms, we opted for linkage analysis with microsatellite markers to investigate whether the candidate genes are involved in the pathogenesis of euthyroid goiter. The markers for the genes TG, TPO, and NIS gave two-point and multipoint logarithm of odds score analysis scores that were negative or below 1 for all assumed recombination fractions. As no significant evidence of linkage was found, we conclude that these candidate genes can be excluded as a major cause of the euthyroid goiters in this family. In contrast, we have found evidence for linkage of familial euthyroid goiter to the recently identified locus for familial multinodular nontoxic goiter (MNG-1) on chromosome 14q. The haplotype cosegregates clearly with familial euthyroid goiter. Our results provide the first confirmation for MNG-1 as a locus for nontoxic goiter.
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19

Pozdnyak, A. O., L. I. Anchikova, and L. N. Kurshakova. "Comparative study of thyroid function in autoimmune thyroiditis and endemic goiter in goiter endemic conditions." Kazan medical journal 69, no. 4 (1988): 245–47. http://dx.doi.org/10.17816/kazmj99602.

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Disturbance of functional state of pituitary-thyroid system in autoimmune thyroiditis and endemic goiter in recent years is attracting more and more attention of researchers. However, in recent years we have not found any works on a comparative study of the thyroid gland function in these lesions in the Russian literature.
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20

Zeltser, M. Ye, N. N. Mezinova, N. N. Kobzar, et al. "The thyroid in anemic pregnant women under conditions of endemic goiter." Problems of Endocrinology 40, no. 5 (1994): 20–22. http://dx.doi.org/10.14341/probl12161.

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Anemia is a highly prevalent condition among pregnant women in the Republic of Kazakhstan. The causes of this anemia are not quite clear, as is the problem of resistance of this type of anemia to therapy with iron preparations. The authors propose that this may be explained by the fact that many regions of the Republic are foci of endemic goiter, because tentative studies indicate a relationship between endemic goiter and hy- pothyrosis. The present study was aimed at examination of the thyroid status in pregnant women suffering from anemia in the town of Alma-Ata, a region endemic for goiter. Altogether 120 anemic pregnant women were examined, 60 of these with goiter and 60 without it. Control group consisted of 20 healthy pregnant women. Clinical and ultrasonic examinations, puncture biopsy of the thyroid, measurements of blood levels of TTH, total and free triiodothyronine and thyroxin, thyroxin-binding globulin, as well as of peripheral blood red cell counts, levels of hemoglobin, serum iron, assessment of total iron-binding capacity of the serum and saturation coefficient, were carried out. Healthy pregnant women from a focus of endemic goiter were found to represent a group at risk of anemia in the third pregnancy trimester. In anemic pregnant women endemic goiter aggravated anemia. Chronic iodine deficiency is conductive to formation in pregnant women of subclinical hypothyrosis whose severity increased in the presence of anemia, more so if anemia is paralleled by goiter.
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21

Kamalov, K. G., E. M. Soltakhanov, and G. A. Gazimagomedov. "The prevalence of endemic goiter and iodine deficiency in the population of boys aged 11–13 years in different ecogeographical regions of the Republic Of Dagestan." Research'n Practical Medicine Journal 5, no. 3 (2018): 10–19. http://dx.doi.org/10.17709/2409-2231-2018-5-3-1.

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Purpose. Conducting a comparative analysis and assessment of the dynamics of endemic goiter and iodine deficiency in the population of boys of the Republic of Dagestan at the age of 11–13 years for the period 2002–2013, living in different ecological and geographical zones.Patients and methods. 3457 adolescent boys 11–13 years old, living in different ecological and geographical zones, were surveyed. Methods of investigation were: determination of daily excretion of iodine in urine, palpation and ultrasound examination of the thyroid gland.Results. It was revealed that during the period of preventive measures there was an improvement in iodine supply regardless of the area of residence. However, against the background of preventive measures in the lowland zone, iodine deficiency decreased not evenly, and in some cases the aggravation occured.Conclusion. The incidence of endemic goiter and the severity of iodine deficiency in boys aged 11–13 years in the mountain and foothill ecology and geographical zones of the Republic of Dagestan are generally comparable to those of iodine deficiency and endemic goiter in the general population of the Republic of Dagestan. On a flat ecogeographical zone, endemic goiter in boys 11-13 years is less common than in the general population in this region. Preventive measures to combat iodine deficiency have led to a decrease in the frequency of endemic goiter, but constant monitoring is required. As a result, there was no correlation between the incidence of endemic goiter and the severity of iodine deficiency.
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22

Kasatkina, E. P. "Iodine deficiency diseases in children and adolescents (plenary lecture)." Problems of Endocrinology 43, no. 3 (2019): 3–7. http://dx.doi.org/10.14341/probl10385.

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The main consequence of iodine deficiency in the environment is the development of goiter in people living in iodine-deficient regions (endemic goiter). In this regard, for a long time it was considered that goiter is the only manifestation of this condition. It has now been proven that, in addition to goiter, iodine deficiency also has other adverse effects on human health. In 1983, the term "endemic goiter" was replaced by the term "iodine deficiency diseases" (IDD). These diseases are caused by a decrease in the functional activity of the thyroid gland in response to iodine deficiency.
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23

Zeltser, M. Ye, T. K. Chuvakova, N. N. Mezinova, et al. "Specific features of adaptation of the newborns born of mothers with endemic goiter." Problems of Endocrinology 40, no. 5 (1994): 18–20. http://dx.doi.org/10.14341/probl12160.

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Relationships between chronic iodine deficiency and, among other things, endemic goiter in women and adaptation of their babies in the early neonatal period were studied. A total of 125 women with endemic goiter of the Ist-IInd degrees and their newborns were examined. The diagnosis of endemic goiter was verified by the findings of an objective examination, ultrasonic examination, and puncture biopsy of the thyroid. Blood levels of triiodothyronine and thyroxin were measured in the women on days 3-4 postpartum. In the newborns Apgar score, body mass and length at birth, degree of maturity, physiologic body mass loss, duration of the icteric syndrome, time of umbilical cord drop off, and immunity status from the data of NBT test were assessed. Forty-five women without goiter and their newborns were controls. Postpartum measurements of triiodothyronine and thyroxin levels in the blood of patients with endemic goiter brought the authors to a conclusion that subclinical hypothyrosis was characteristic of them. Adaptation processes in the early neonatal period were found disordered in the newborns of mothers with endemic goiter. This manifested by a higher, vs. controls, incidence of asphyxia, hypotrophy, signs of the CNS involvement, and respiratory distress syndrome. Initial body mass recovery, disappearance of the icteric syndrome, umbilical cord loss were delayed in these newborns in comparison with the controls, and statistically reliable deviations in their immune status were revealed.
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Problems of endocrinology, Journal. "Rajab Kaplanovich Islambekov (on the occasion of his 70th birthday)." Problems of Endocrinology 42, no. 1 (1996): 45. http://dx.doi.org/10.14341/probl11929.

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70 years have passed since the birth of the famous scientist endocrinologist - consultant of the Endocrinological Research Center of the Russian Academy of Medical Sciences, corresponding member of the Russian Academy of Medical Sciences, Lenin Prize laureate, Honored Scientist of the Republic of Uzbekistan, Doctor of Medical Sciences, Professor Rajab Kaplanovich Islamambekov. R.K. Islambekov in 1947 graduated from the Tashkent Medical Institute, and in 1950 - graduate school. R.K. Islambekov was one of the organizers of the Institute of Regional Medicine (now the Institute of Endocrinology) in Tashkent, where he worked for 18 years - first the head of the laboratory, then the head of the endocrinology department and the director of the institute. In 1961 he defended his doctoral dissertation "Clinical and morphological study of endemic goiter." R.K. Islambekov is a talented scientist whose scientific interests are concentrated in the field of physiology and pathology of the thyroid gland, problems of endemic goiter. He is one of the pioneers of introducing in the USSR methods of diagnosing and treating thyroid diseases with radioactive iodine. R. K. Islambekov proposed and substantiated the concept of the role of iodine and other trace elements in the multifactorial etiology of endemic goiter, on the basis of which a drug was created for the prevention and treatment of endemic goiter. R.K.Islambekov is the organizer of many expeditions to study the etiology, pathogenesis, and prevalence of endemic goiter in Uzbekistan, to conduct mass iodine prophylaxis, as a result of which the incidence of endemic goiter in this region has sharply decreased.
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25

Aranovich, V. V. "Catamnesis of Endemic Goiter in Children." Clinical and experimental thyroidology 1, no. 1 (2005): 48. http://dx.doi.org/10.14341/ket20051148-54.

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26

Weetman, A. P. "Is endemic goiter an autoimmune disease?" Journal of Clinical Endocrinology & Metabolism 78, no. 5 (1994): 1017–19. http://dx.doi.org/10.1210/jcem.78.5.7909815.

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27

Sugawara, M., C. N. Summer, A. Kobayashi, S. Murakami, K. Kuma, and G. A. Medeiros-Neto. "Thyroid peroxidase in endemic goiter tissue." Journal of Endocrinological Investigation 13, no. 11 (1990): 893–99. http://dx.doi.org/10.1007/bf03349648.

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28

Tripathy, Smritiratan. "Age, sex, religion and caste specific goitre prevalence in Murshidabad district of West Bengal, India." INDIAN JOURNAL OF PHYSIOLOGY AND ALLIED SCIENCES 74, no. 04 (2022): 21–23. http://dx.doi.org/10.55184/ijpas.v74i04.80.

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Goitre prevalence of selected population in respect of age, sex, religion and caste was evaluated in the Murshidabad district of West Bengal during post salt iodization phase. The study was carried out on 9321 school children in the age group 6-12 years of both sexes from randomly selected 26 representative localities from all 26 Community Development Blocks. Children were clinically examined for goitre. Result showed that the prevalence of goitre was found at endemic level. The overall goitre prevalence was found 22.1%. Besides palpable goiter (2.5%), the prevalence of visible goiter (19.7%) in school children was prevalent. A gradual increase in goitre rate was found from the age of 6 yr till the age of 8 yr followed by a short decline at the age of 9 yr to 12 yr. Goitre was most prevalent in Hindus (23.7%) than Muslim (21.4%) communities. Among the Hindus, general caste (20.8%) students suffered more than Scheduled caste & Scheduled tribe (19.0%). These variations in goitre prevalence among different caste and religions might be due to their different environmental adaptability and dietary habit.
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29

Evseeva, S. A., T. E. Burtseva, T. M. Klimova, N. A. Danilov, V. G. Chasnyk, and N. I. Douglas. "Frequency of endemic goiter and indicators of pituitary-thyroid profile in Arctic children." Perm Medical Journal 38, no. 4 (2021): 18–24. http://dx.doi.org/10.17816/pmj38418-24.

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Objective. Analysis of the frequency of endemic goiter and indicators of the pituitary-thyroid profile in children aged 10-18 years living in the Arctic regions of Yakutia.
 Materials and methods. The study was conducted among children and adolescents of the Arctic regions of Yakutia (Bulunsky, Anabarsky, Allaikhovsky, Nizhnekolymsky, Verkhnekolymsky district) during field medical expeditions in 20182020. A total of 392 children aged 1018 years were examined.
 Results. In 30 % of the examined children, an increase in the thyroid gland was observed, which was accompanied by elevated levels of free thyroxine. In 3 % of children, an increase in the level of thyroid-stimulating hormone was detected against the background of reduced or normal levels of free thyroxine.
 Conclusions. As for the prevalence of cases of endemic goiter, the Arctic regions of Yakutia are the areas of severe goiter endemia. The results obtained justify the need for additional scientific studies to assess the degree of iodine availability (by the concentration of iodine in the urine) in different population groups and real implementation of the strategy of mass preventive measures.
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AKBAR, SYED ALI, Mohammad Qasim, NAZIR AHMED, Zar Khan, JOHAR ALI, and Nazar Mohammad Afridi. "MULTI NODULAR GOITER." Professional Medical Journal 17, no. 01 (2010): 40–43. http://dx.doi.org/10.29309/tpmj/2010.17.01.1976.

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Objective: I. To determine the frequency of malignancy in multi nodular goiter. II. To determine the histopathological types.Design: This is a prospective study. Setting: Surgical department of Foundation Hospital Rawalpindi and associated Teaching Hospital ofFrontier Medical College Abbottabad. Period: Aug. 2002 to Aug. 2007. Patients and Methods. One hundred patients with Multi nodular wereincluded in this study. Patient with diffuse goiter, solitary nodules, patient operated somewhere else and suspected cases of malignancy wereexcluded from the study. Tissue were sent to Armed Force Institute for histopathological examination. Patients were followed for 2 weeks aftersurgery with histopathological report, all the preoperative and postoperative findings were recorded in detail. Data was analyzed byusingSPSS 14. Results. Majority of patients studied, belonged to Azad Kashmir and Gilgit which are among the known endemic regions for goitrein Pakistan and other from Chakwal and Jhelum. Histopathology revealed 96 (96%) patients with multi nodular goiter, 3 (3%) papillary carcinomaand 1 (1 %) Follicular carcinoma. Conclusions: Multinodularity of the goitre should not be considered as low risk of malignancy and delay forsurgical intervention. Changes in the size of gland, the appearance of new and hard nodules or cervical lymphadenopathy may indicatemalignant change and prompt indication for surgery.
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Svinarev, M. Yu, L. A. Lisenkova, and G. M. Shub. "Antithyroid immunity in children with endemic goiter." Problems of Endocrinology 43, no. 6 (1997): 22–25. http://dx.doi.org/10.14341/probl199743622-25.

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Thyroid immunity is assessed in 246 children aged 6 to 16 living in a region with moderate iodine deficit (the Khvalynsk region of the Saratov district). A total of 203 children with endemic goiter of the first-third degree and 43 children with normal-sized thyroid were examined using the ultrasonic method, measurements of the blood levels of T3, T4, and TTH, estimation of the [(T3+T4)/TTH] index, and assessment of the urinary excretion of inorganic iodine. Serum autoantibodies to the microsomal antigen (MAg) and thyroglobulin (TG) were assayed by ELISA. Autoantibodies to MAg and/or TG were detected in 10.8%) of children with endemic goiter and 2.3%o of those without enlargement of the thyroid. The rate of detection of autoantibodies increases with age (p<0.05) and is parallel with increase in the size of the thyroid (up to 21.1%o in third- degree goiter, p<0.02). Autoantibodies were detected much more often in children with various echographically detected dijfuse changes in the thyroid structure (from 17.8 to 42.9%o vs. 8.6% in cases with the intact structure of the organ). Serum TTH level was reliably increased and the thyroid index decreased in “seropositive” children (p<0.01). The findings confirm the relationship between inadequate consumption of iodine and immunological reactivity of children and demonstrate certain regularities in the development of autoimmune disorders in children with endemic goiter.
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Mezdoud, Afaf, Selma Agli, Abdel-Nacer Agli, Nora Bahchachi, and Hayet Oulamara. "Consumption of Cruciferous Foods, Ingestion of Glucosinolates and Goiter in a Region of Eastern Algeria." Current Research in Nutrition and Food Science Journal 10, no. 3 (2022): 1169–77. http://dx.doi.org/10.12944/crnfsj.10.3.30.

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This study is about the estimation of the consumption of cruciferous vegetables, and the search for a possible relationship between the ingestion of glucosinolates provided by these foods and the emergence of endemic goiter. A prospective cohort survey was carried out on 1098 subjects residing in the district of EL-MILIA (Algeria) where endemic goiter is known to estimate the consumption of crucifers. Total glucosinolates levels in cruciferous vegetables, cabbage, cauliflower, fresh and cooked turnip and radish were determined by the glucose release method. The goiter was detected by clinical investigation. Both various fresh and cooked cruciferous vegetables have the same total glucosinolates levels as reported in other studies. The prevalence of endemic goiter was 17.5 %. The average consumption of crucifers was 380.30 g per person a week, i.e. 54.32 g per person a day, and the weekly ingestion of glucosinolates per person was 369.4 μmoles, or 52.7 μmoles per day. No dependence was observed between the consumption of glucosinolates and the disease in general. However, isolated stage 2 and 3 of goiter were dependent on the consumption of glucosinolates ; stage 1 was not related to the disease. Despite the current consumption, at EL-MILIA, we estimate that glucosinolate’s ingestion does not cause goiter, but may worsen the condition of subjects already affected.
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Mayya, Jaya Prakasha, Nabin Gautam, Apar Pokharel, and Bikash Pandey. "Case report: An interesting case of large colloid goiter with dyspnea." Journal of College of Medical Sciences-Nepal 13, no. 4 (2017): 430–32. http://dx.doi.org/10.3126/jcmsn.v13i4.18680.

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Benign nodular goitre is one of the most common endocrine disorder, especially in countries like Nepal where iodine deficiency is endemic. Case History: A 59 years old female presented with large thyroid swelling. Investigations showed it to be colloid goiter compressing the airway. Left hemithyroidectomy was done. Post operative period was uneventful.Discussion: Management of thyroid nodules depends upon assessment of thyroid function, fine needle aspiration cytology and imaging. Surgery is the common method of treatment.
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34

Abdullin, I. A., I. B. Sitdikov, and I. A. Ryazanov. "Some particular problems of chemistry and hygiene." Kazan medical journal 76, no. 4 (1995): 314–16. http://dx.doi.org/10.17816/kazmj104868.

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Starting from 1950, scientific centers were established in various cities of the USSR to study microelements, to study their biological role and content in environmental objects, tissues, organs, liquid media of a living organism, in normal and pathological conditions, to elucidate their role in the etiology and pathogenesis of various diseases, prevention and treatment of diseases. Tatarstan is endemic for goiter region. It is well known that endemic goiter occurs due to a lack of iodine in nature. The soil serves as a "supplier" of iodine for plants, animals and humans, so its role in the iodine cycle in nature can be considered a leading one. Consequently, the organization of a successful fight against endemic goiter is unthinkable without comprehensive studies of the biogeochemical situation in endemic foci and in the whole country, especially without taking into account the content of various forms of iodine in soils [13].
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35

Maddeppungeng, Martira, and R. Satriono. "Dermatoglyphic patterns of goitrous children in endemic iodine deficiency area." Paediatrica Indonesiana 44, no. 3 (2016): 117. http://dx.doi.org/10.14238/pi44.3.2004.117-20.

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Background Goiter mapping on elementary school students in1998 showed that the prevalence of endemic goiter was still highat Enrekang regency, South Sulawesi despite various programs tomanage this problem. This raised questions if there were any otherfactors that contribute to the occurrence of goiter e.g. genetic fac-tor, which can be assessed indirectly by dermatoglyphic pattern.Objective To determine the dermatoglyphic pattern in goitrouschildren and compare it to normal children.Methods A cross sectional study was done to investigate the cor-relation between goiter and dermatoglyphic patterns on 115 el-ementary school students at Anggeraja and Baraka subdistricts,Enrekang regency. Dermatoglyphic patterns of finger tips of bothhands and right hallux were scanned using Prolink scanner withMaximum Resolution of 19200x19200dpi and interpreted usingphoto/image editing computer program.Results Seventy two (62.6%) of 115 children were goitrous, sev-enty (97%) were of stage1, and 2 (3%) of stage 2. No significantdifference was found in dermatoglyphic patterns between normaland goitrous children. Tibial loop pattern of the right hallux tendedto be more frequent in goitrous children than that of normal chil-dren, but it was not statistically different (in level of significancy of0.05) compared to normal children (p=0.085).Conclusions This study indicates that the possibility of the role of ge-netic factor in the development of goiter in endemic area is unlikely
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Gerasimov, Gregory A. "Not that simple goiter." Clinical and experimental thyroidology 16, no. 3 (2021): 4–11. http://dx.doi.org/10.14341/ket12696.

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The year 2020 marks the centenary of the publication of a classic study by American physicians D. Marine and O. Kimball on the effectiveness of endemic goiter prevention in children in Akron, Ohio. Although goiter has been known from immemorial times, there is still a problem with determining the normal size of the thyroid gland, without which the diagnosis of goiter remains extremely subjective. For example, in Sweden over the past 20 years, not a single case of endemic goiter has been registered, which is not surprising: the country eliminated this pathology decades ago, and the median urinary iodine concentration indicates the optimal iodine intake. Cases of sporadic goiter in children in Sweden are also rare — no more than 6–8 per year. But in Belarus, with the same population (about 10 million), about 2900 cases of goiter in children, both endemic and sporadic, are recorded annually despite the fact that, due to the extensive use of iodized salt since the beginning of the 2000s, there is no iodine deficiency. The incidence of goiter in children, however, having decreased many times over the past 20 years, remains 3 times higher than in Russia, where iodine prophylaxis, if carried out on a limited scale. From the experience of Belarus, Sweden and Russia, we see that the main thing when assessing data on the incidence of goiter and other thyroid diseases associated with iodine deficiency should be not absolute numbers, but the trend of these indicators over the past years. This information should be more actively used by endocrinologists in Russia to assess the effectiveness of preventive measures both at the regional and federal levels.
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37

Röher, Hans-Dietrich, and Peter Erich Goretzki. "Management of Goiter and Thyroid Nodules in an Area of Endemic Goiter." Surgical Clinics of North America 67, no. 2 (1987): 233–49. http://dx.doi.org/10.1016/s0039-6109(16)44181-2.

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38

Kalinin, A. P., V. S. Lukyanchikov, and Nguyen Khan Viet. "Modern aspects of thyrotoxicosis (lecture)." Problems of Endocrinology 46, no. 4 (2000): 23–26. http://dx.doi.org/10.14341/probl11860.

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Among the current medical and social problems, one of the most urgent is the pathology of the thyroid gland (thyroid gland). This is due to the fact that the total frequency of various forms of this pathology, even outside areas of goiter endemic, is at least 20% of the total incidence. In goiter endemic regions, where approximately 1/3 of the human population lives, this figure often exceeds 50%.
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Ramadhaningtiyas, Ahshaina, Yulia Lanti Retno Dewi, and Sugihardjo Sugihardjo. "Factors Associated with Goiter Incidence in Farmers in Kismantoro Sub-District, Wonogiri Regency." Amerta Nutrition 6, no. 2 (2022): 148–54. http://dx.doi.org/10.20473/amnt.v6i2.2022.148-154.

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Background: Kismantoro Sub-district has been an endemic area of ​​severe goiter since 1982, with a total goiter rate of 35.5% until 2007, when was declared a mild endemic goiter area (TGR 10.79%). Monitoring in 2017 on salt circulating in Wonogiri exposed that there were still 26.01% of brands that did not meet the Indonesian national standard. Objective: This study aimed to analyze the factors associated with goiter incidence in Kismantoro Sub-district, Wonogiri Regency. Methods: This research applied analytic observational with a case-control design. The samples were 41 respondents in the case group and 41 respondents in the control group, taken by purposive sampling. The history of goiter was obtained from the medical records of Kismantoro Community Health Center. The data analysis method employed was logistic regression analysis. Results: The results showed a significant correlation between age (p 0.005, OR 5.88, 95%CI 1.53-22.62), gender (p 0.003, OR 0.15, 95%CI 0.04-0.58), and salt iodine content (p 0.007, OR 0.14, 95%CI 0.03-0.68) with the goiter incidence in farmers in Kismantoro. Moreover, the multiple logistic regression test results revealed that age was the most dominant variable influencing the goiter incidence (p 0.006, OR 8.103, 95%CI (1.799-36.499). Conclusion: There was a relationship between age and the goiter incidence, gender with the goiter incidence, and iodine content in household salt with the goiter incidence, the multiple logistic regression test results indicated that the age variable most influenced goiter incidence among farmers in Kismantoro Sub-District, Wonogiri Regency.
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40

Agarwal, Amit, Anand K. Mishra, Sushil K. Gupta, et al. "High Incidence of Tracheomalacia in Longstanding Goiters: Experience from an Endemic Goiter Region." World Journal of Surgery 31, no. 4 (2007): 832–37. http://dx.doi.org/10.1007/s00268-006-0565-8.

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41

Schrell, U., M. Buchfelder, J. Hensen, et al. "Somatostatin Receptor Expression in the Thyroid Demonstrated with 111In-Octreotide Scintigraphy." Nuklearmedizin 34, no. 03 (1995): 100–103. http://dx.doi.org/10.1055/s-0038-1629763.

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SummaryNeuroendocrine tumors with somatostatin receptor expression may be localized by 111ln-octreotide scintigraphy. This study examines those thyroid conditions where 111 ln-octreotide uptake could be observed also in the thyroid gland. 26 consecutive patients who underwent 111 ln-octreotide scintigraphy for tumor localization were additionally examined for thyroid disease by sonography and 99mTc-pertechnetate scintigraphy. 12 of these patients had no significant thyroid uptake and had an euthyroid normal-sized thyroid gland. 14 patiens with 111ln thyroid uptakes had endemic goiters, two of them with thyroid autonomy and one with Graves’ disease. Thus, 111 ln-octreotide thyroid uptake was predominantly seen in patients with endemic goiter with or without thyroid autonomy.
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42

Danovsky, L. V. "Some questions of the clinic of endemic goiter in the Leninogorsk region of the Tatar ASSR." Kazan medical journal 43, no. 6 (2021): 17–19. http://dx.doi.org/10.17816/kazmj83210.

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43

ROTI, ELIO, ELIANA GARDINI, LORENZO D′AMATO, et al. "Goiter Size and Thyroid Function in an Endemic Goiter Area in Northern Italy *." Journal of Clinical Endocrinology & Metabolism 63, no. 3 (1986): 558–63. http://dx.doi.org/10.1210/jcem-63-3-558.

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44

Hidayat, Muhammad Taufiq, Selfi Handayani, and Siti Munawaroh. "Pengaruh Usia Menarche terhadap Tinggi Badan Wanita di Daerah Endemis Gondok." Smart Medical Journal 1, no. 2 (2018): 89. http://dx.doi.org/10.13057/smj.v1i2.28882.

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<p class="AbstractNormal"><strong><em><span lang="EN-ID">Introduction</span>: </em></strong><em>Height affected by various factor. One factor that can affect female’s height is menarcheal age. Sexual hormone in female’s body will be activated at menarche and it will stimulate the closure of epiphyseal plate. Final height in female with late menarche is higher than female with early menarche. While in goiter endemic areas with Iodine Deficiency Disorder especially in mountain area, it has earlier menarcheal age than normal female that live in non goiter endemic area. This study aimed to analyze the relationship between age at menarche and height endemic goiter.</em></p><p class="AbstractNormal"><strong><em>Method</em></strong><em>s: This study was an observational study with cross-sectional design. It was held in the goiter endemic Ngargoyoso, Karanganyar. Samples of women aged over 20 years with upright posture that live in Ngargoyoso were obtained by simple random sampling, then measuring the height using statometer and obtaining menarcheal age by questioner. Data were analyzed using Pearson correlation test (α = 0.05), which had previously been tested for normality by Kolmogorov Smirnov.</em></p><p class="AbstractNormal"><strong><em>Results: </em></strong><em>The mean age of menarche sample was 13.38 years with the lowest age of 11 years and the highest age of 18 years. While the average height was 156.8 cm samples with the lowest height was 139 cm and the highest was 168 cm. Pearson correlation test results showed that height was significantly associated with age at menarche woman endemic goiter (p = 0.001).</em></p><p class="AbstractNormal"><strong><em>Conclusions: </em></strong><em>Age of menarche associated with height in an endemic goiter area.<br />The earlier age of menarche will affect the final height of the woman.</em></p><p class="Keywords"> </p>
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BÄHRE, M. "Frequency of thyroid in an endemic goiter area." Acta Endocrinologica 116, no. 3_Suppl (1987): S157. http://dx.doi.org/10.1530/acta.0.114s157a.

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46

Chaouki, M. L., F. Delange, R. Maoui, P. Bourdoux, A. M. Ermans, and M. Benmiloud. "65 NEONATAL HYPOTHYROIDISM IN ENDEMIC GOITER IN ALGERIA." Pediatric Research 19, no. 6 (1985): 614. http://dx.doi.org/10.1203/00006450-198506000-00085.

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47

SUGAWARA, MASAHIRO, TAKESHI KITA, EDWARD D. LEE, et al. "Deficiency of Superoxide Dismutase in Endemic Goiter Tissue*." Journal of Clinical Endocrinology & Metabolism 67, no. 6 (1988): 1156–61. http://dx.doi.org/10.1210/jcem-67-6-1156.

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48

KNOBEL, MEYER, EUFROSINA S. UMEZAWA, MARIA SILVIA CARDIA, et al. "Elevated Anti-Galactosyl Antibody Titers in Endemic Goiter." Thyroid 9, no. 5 (1999): 493–98. http://dx.doi.org/10.1089/thy.1999.9.493.

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49

Gatseva, Penka, Stefka Vladeva, and Mariana Argirova. "Evaluation of endemic goiter prevalence in Bulgarian schoolchildren." Biological Trace Element Research 116, no. 3 (2007): 273–78. http://dx.doi.org/10.1007/bf02698011.

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50

Klingler, P. J., S. Strolz, C. Profanter, et al. "Management of Hyperparathyroidism in an Endemic Goiter Area." World Journal of Surgery 22, no. 3 (1998): 301–8. http://dx.doi.org/10.1007/s002689900386.

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