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1

Lee, Dong Kwon, Sung Il Park, Jong K. Lee, and Nong Moon Hwang. "A Theoretical Model for Digestive Ripening." Materials Science Forum 561-565 (October 2007): 2279–82. http://dx.doi.org/10.4028/www.scientific.net/msf.561-565.2279.

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Recently, gram quantities of monodisperse gold or silver nanoparticles were reported to be produced through a digestive ripening process, in which colloidal particles of size 2 to 40 nm are transformed to nearly monodisperse particles of 4 ~ 5 nm diameter. Digestive ripening, an example for an inverse Ostwald ripening process, is a puzzling phenomenon since it appears to go against the usual capillary effect, i.e., reduction of interfacial free energy. A theoretical model is presented, which accounts for the monodisperse state of such nanoparticles by considering the effect of charges on the particles and thus electrostatic energy during particle size evolution.
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2

Prasad, B. L. V., Savka I. Stoeva, Christopher M. Sorensen, and Kenneth J. Klabunde. "Digestive-Ripening Agents for Gold Nanoparticles: Alternatives to Thiols." Chemistry of Materials 15, no. 4 (February 2003): 935–42. http://dx.doi.org/10.1021/cm0206439.

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3

Capek, Ignác. "Noble Metal Nanoparticles and Their (Bio) Conjugates. II. Preparation." International Journal of Chemistry 8, no. 1 (January 6, 2016): 86. http://dx.doi.org/10.5539/ijc.v8n1p86.

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Hybrid nanoparticles of gold and silver can not only retain the beneficial features of both nanomaterials, but also possess unique advantages (synergism) over the other two types. Novel pseudospherical and anisotropic nanoparticles, bimetallic triangular nanoparticles, and core@shell nanoparticles were prepared by the different procedures for various applications and understanding both the particle evolution (nucleation) and nanoparticle anisotropy. Hybrid nanoparticles of gold and silver are considered to be low in toxicity, and exhibit facile surface functionalization chemistry. Furthermore, their absorption peaks are located in visible and near-infrared region. These nanoparticles provide significant plasmon tunability, chemical and surface modification properties, and significant advances in the growth into anisotropic nanostructures. The photoinduced synthesis can be used to prepare various (sub) nanoparticles and OD and 1D nanoparticles. Ostwald and digestive ripening provided narrower particle size distribution.
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4

Lin, Meng-Lin, Fuqian Yang, J. S. Peng, and Sanboh Lee. "Field effect on digestive ripening of thiol-capped gold nanoparticles." Journal of Applied Physics 115, no. 5 (February 7, 2014): 054312. http://dx.doi.org/10.1063/1.4863784.

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5

Fernandez, Carlos A., and Chien W. Wai. "A Simple and Rapid Method of Making 2D and 3D Arrays of Gold Nanoparticles." Journal of Nanoscience and Nanotechnology 6, no. 3 (March 1, 2006): 669–74. http://dx.doi.org/10.1166/jnn.2006.120.

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Monodispersive gold nanoparticles can be synthesized by a dropwise addition of a reducing agent microemulsion to a gold ion microemulsion followed by immediate stabilization with 1-decanethiol. No size-selective precipitations or digestive ripening procedures are necessary. There is no need for metal functionalization of the surfactant AOT. Gold nanoparticles with an average size of 3.8 nm and a relative size dispersion of 5.4% were observed using n-heptane as a solvent. It seems possible to adjust the nanoparticle size by small changes in the carbon chain length of the solvent. Self-assembled 2D and 3D arrays of gold nanoparticles with adjustable sizes have been obtained on carbon-coated copper grids and on a silicon wafer. The arrays have good crystallinity as evidenced by the external morphology and transmission electron diffraction results. The size of the gold nanoparticle 3D arrays depends on the immersion time and can be greater than 15 μm. This approach could be used to synthesize other noble metal nanoparticle arrays that may lead to new materials for electronic and photonic applications.
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6

Sahu, Puspanjali, and Bhagavatula L. V. Prasad. "Time and Temperature Effects on the Digestive Ripening of Gold Nanoparticles: Is There a Crossover from Digestive Ripening to Ostwald Ripening?" Langmuir 30, no. 34 (August 18, 2014): 10143–50. http://dx.doi.org/10.1021/la500914j.

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7

Prasad, B. L. V., Savka I. Stoeva, Christopher M. Sorensen, and Kenneth J. Klabunde. "Digestive Ripening of Thiolated Gold Nanoparticles: The Effect of Alkyl Chain Length." Langmuir 18, no. 20 (October 2002): 7515–20. http://dx.doi.org/10.1021/la020181d.

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8

Smetana, Alexander B., Kenneth J. Klabunde, Christopher M. Sorensen, Audaldo A. Ponce, and Benny Mwale. "Low-Temperature Metallic Alloying of Copper and Silver Nanoparticles with Gold Nanoparticles through Digestive Ripening." Journal of Physical Chemistry B 110, no. 5 (February 2006): 2155–58. http://dx.doi.org/10.1021/jp0539932.

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9

Sun, Yijun, Deepa Jose, Christopher Sorensen, and Kenneth Klabunde. "Alkyl and Aromatic Amines as Digestive Ripening/Size Focusing Agents for Gold Nanoparticles." Nanomaterials 3, no. 3 (July 5, 2013): 370–92. http://dx.doi.org/10.3390/nano3030370.

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10

Su, Ying-Ying, Fuqian Yang, and Sanboh Lee. "Digestive ripening of thiol-capped gold nanoparticles: effects of temperature and electric field." Materials Research Express 2, no. 5 (May 11, 2015): 055007. http://dx.doi.org/10.1088/2053-1591/2/5/055007.

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11

Silvestri, Alessandro, Laura Polito, Giacomo Bellani, Vanessa Zambelli, Ravindra P. Jumde, Rinaldo Psaro, and Claudio Evangelisti. "Gold nanoparticles obtained by aqueous digestive ripening: Their application as X-ray contrast agents." Journal of Colloid and Interface Science 439 (February 2015): 28–33. http://dx.doi.org/10.1016/j.jcis.2014.10.025.

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12

Liu, Fu-Ken. "Using Size-Exclusion Chromatography to Monitor Variations in the Sizes of Microwave-Irradiated Gold Nanoparticles." ISRN Chromatography 2012 (December 13, 2012): 1–7. http://dx.doi.org/10.5402/2012/970685.

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Size-exclusion chromatography (SEC) was used to evaluate gold nanoparticles (Au NPs) for variations in their sizes after microwave (MW) irradiation, with the eluted NPs monitored through diode array detection to reveal their surface plasmon absorptions. The sizes of citrate-capped Au NPs decreased upon increasing the MW irradiation temperature, consistent with digestive ripening of these NPs under the operating conditions. In contrast, Au NPs capped with sodium dodecyl sulfate increased in size upon increasing the MW irradiation temperature, consistent with Ostwald ripening. When the Au NPs were capped with 3A-amino-3A-deoxy-(2AS,3AS)--cyclodextrin (H2N--CD), however, their dimensions were barely affected by the MW irradiation temperature, confirming that H2N--CD is a good stabilizer against MW irradiation. Therefore, SEC—with its short analysis times, low operating costs, automated operation, and in situ analysis—has great potential for use in the rapid monitoring of NPs subjected to treatment under various MW irradiation conditions.
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13

Lin, Meng-Lin, Fuqian Yang, and Sanboh Lee. "Digestive ripening for self-assembly of thiol-capped gold nanoparticles: the effects of adding dodecanethiol and reflux-heating." Colloids and Surfaces A: Physicochemical and Engineering Aspects 448 (April 2014): 16–22. http://dx.doi.org/10.1016/j.colsurfa.2014.01.081.

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14

Irzhak, V. I. "Digestive ripening of nanoparticles." Russian Journal of Physical Chemistry A 91, no. 8 (July 15, 2017): 1502–6. http://dx.doi.org/10.1134/s0036024417080131.

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15

Jose, Deepa, and Balaji R. Jagirdar. "Au@Pd Core−Shell Nanoparticles through Digestive Ripening." Journal of Physical Chemistry C 112, no. 27 (June 12, 2008): 10089–94. http://dx.doi.org/10.1021/jp802721s.

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16

Sahu, Puspanjali, Jayesh Shimpi, Han Ju Lee, T. Randall Lee, and Bhagavatula L. V. Prasad. "Digestive Ripening of Au Nanoparticles Using Multidentate Ligands." Langmuir 33, no. 8 (February 16, 2017): 1943–50. http://dx.doi.org/10.1021/acs.langmuir.6b03998.

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17

Turba, Timothy, M. Grant Norton, Ishwar Niraula, and David N. McIlroy. "Ripening of nanowire-supported gold nanoparticles." Journal of Nanoparticle Research 11, no. 8 (December 27, 2008): 2137–43. http://dx.doi.org/10.1007/s11051-008-9580-z.

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18

Manzanares, José A., Pekka Peljo, and Hubert H. Girault. "Understanding Digestive Ripening of Ligand-Stabilized, Charged Metal Nanoparticles." Journal of Physical Chemistry C 121, no. 24 (June 13, 2017): 13405–11. http://dx.doi.org/10.1021/acs.jpcc.7b04234.

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19

Cingarapu, Sreeram, Zhiqiang Yang, Christopher M. Sorensen, and Kenneth J. Klabunde. "Synthesis of Indium Nanoparticles: Digestive Ripening under Mild Conditions." Inorganic Chemistry 50, no. 11 (June 6, 2011): 5000–5005. http://dx.doi.org/10.1021/ic200232b.

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20

Irzhak, T. F., and V. I. Irzhak. "On the mechanism of the process of digestive ripening." Доклады Академии наук 486, no. 5 (June 20, 2019): 554–57. http://dx.doi.org/10.31857/s0869-56524865554-557.

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The literature describes a relatively new method of regulating the size distribution function of nanoparticles - the process of digestive ripening, which, unlike Ostwald ripening, consists in dissolving large nanoparticles and forming small ones. However, a reasonable explanation of this phenomenon is still missing. The work substantiates the mechanism of the process, based on taking into account the dependence of the critical radius of the nanoparticle on the concentration of monomeric units and the size of the ligand layer.
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21

Yu, Liang, Hongjun You, Qifan Zhang, Lingling Zhang, and Jixiang Fang. "Digestive ripening mechanism investigation in a classical Lee–Meisel method based on in situ UV-vis spectra." CrystEngComm 21, no. 10 (2019): 1529–33. http://dx.doi.org/10.1039/c8ce02041h.

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22

Kalidindi, Suresh Babu, and Balaji R. Jagirdar. "Highly Monodisperse Colloidal Magnesium Nanoparticles by Room Temperature Digestive Ripening." Inorganic Chemistry 48, no. 10 (May 18, 2009): 4524–29. http://dx.doi.org/10.1021/ic9003577.

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23

Lee, Dong-Kwon, and Nong-Moon Hwang. "Thermodynamics and kinetics of monodisperse alloy nanoparticles synthesized through digestive ripening." Scripta Materialia 61, no. 3 (August 2009): 304–7. http://dx.doi.org/10.1016/j.scriptamat.2009.04.008.

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24

Kalidindi, Suresh Babu, and Balaji R. Jagirdar. "Correction to Highly Monodisperse Colloidal Magnesium Nanoparticles by Room Temperature Digestive Ripening." Inorganic Chemistry 48, no. 22 (November 16, 2009): 10856. http://dx.doi.org/10.1021/ic901983m.

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25

Qi, Chunyu, Li Chen, Yuan Gao, Yue Wang, Jing Li, Ligong Zhang, Yongshi Luo, and Xiaojun Wang. "Digestive Ripening-Mediated Growth of NaYbF4:Tm@NaYF4 Core–Shell Nanoparticles for Bioimaging." ACS Applied Nano Materials 3, no. 10 (September 25, 2020): 10049–56. http://dx.doi.org/10.1021/acsanm.0c02057.

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26

Shaik, A. H., and J. Chakraborty. "Synthesis of monodisperse copper nanoparticles using a modified digestive ripening technique and formation of superlattices." RSC Advances 5, no. 104 (2015): 85974–77. http://dx.doi.org/10.1039/c5ra16508c.

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27

LaLonde, Aaron D., M. Grant Norton, Daqing Zhang, Devananda Gangadean, Abdullah Alkhateeb, Radhakrishnan Padmanabhan, and David N. McIlroy. "Controlled Growth of Gold Nanoparticles on Silica Nanowires." Journal of Materials Research 20, no. 11 (November 2005): 3021–27. http://dx.doi.org/10.1557/jmr.2005.0368.

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Production of gold nanoparticles with the specific goal of particle size control has been investigated by systematic variation of chamber pressure and substrate temperature. Gold nanoparticles have been synthesized on SiO2 nanowires by plasma-enhanced chemical vapor deposition. Determination of particle size and particle size distribution was done using transmission electron microscopy. Average nanoparticle diameters were between 4 and 12 nm, with particle size increasing as substrate temperature increased from 573 to 873 K. A bimodal size distribution was observed at temperatures ≥723 K indicating Ostwald ripening dominated by surface diffusion. The activation energy for surface diffusion of gold on SiO2 was determined to be 10.4 kJ/mol. Particle sizes were found to go through a maximum with increases in chamber pressure. Competition between diffusion within the vapor and dissociation of the precursor caused the pressure effect.
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28

Kalidindi, Suresh Babu, and Balaji R. Jagirdar. "Synthesis of Cu@ZnO Core−Shell Nanocomposite through Digestive Ripening of Cu and Zn Nanoparticles." Journal of Physical Chemistry C 112, no. 11 (February 23, 2008): 4042–48. http://dx.doi.org/10.1021/jp7100896.

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29

Arora, Neha, Balaji R. Jagirdar, and Kenneth J. Klabunde. "Digestive ripening facilitated atomic diffusion at nanosize regime: Case of AuIn2 and Ag3In intermetallic nanoparticles." Journal of Alloys and Compounds 610 (October 2014): 35–44. http://dx.doi.org/10.1016/j.jallcom.2014.04.190.

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30

Bhaskar, Srilakshmi P., Minikumari S. Karthika, and Balaji R. Jagirdar. "Au/CdS Nanocomposite through Digestive Ripening of Au and CdS Nanoparticles and Its Photocatalytic Activity." ChemistrySelect 3, no. 23 (June 20, 2018): 6638–46. http://dx.doi.org/10.1002/slct.201801157.

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31

Mainali, Badri P., Dhruba K. Pattadar, and Francis P. Zamborini. "Size-Dependent Ripening of Gold Nanoparticles through Repetitive Electrochemical Surface Oxidation-Reduction Cycling." Journal of The Electrochemical Society 167, no. 14 (October 19, 2020): 146503. http://dx.doi.org/10.1149/1945-7111/abbd72.

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32

Škarkováa, Pavlína, Tea Romih, Monika Kos, Sara Novak, Veno Kononenko, Anita Jemec, Milada Vávrová, and Damjana Drobne. "Gold nanoparticles do not induce adverse effects on terrestrial isopods Porcellio scaber after 14-day exposure." Acta Biologica Slovenica 59, no. 1 (July 1, 2016): 33–44. http://dx.doi.org/10.14720/abs.59.1.15697.

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Despite the anticipated environmental release of anthropogenic gold nanoparticles (AuNPs), there is currently not enough data on their potential impact on terrestrial environment. In the current study, we investigated the effects of considerably low concentrations of AuNPs on terrestrial isopods (Porcellio scaber) after 14 days of exposure. The effects on mortality, weight change, feeding rate, avoidance/preference feeding behavior, and cell membrane destabilization of digestive gland cells were followed. In parallel, the accumulation of Au in the digestive glands was measured. Our results show that none of the tested parameters was affected in isopods under given exposure doses (10 and 60 µg Au/g dry leaf) and exposure duration. No Au was assimilated in the digestive glands. Also, the same doses of the reference chemical, AuCl3, showed no effect. We conclude that these concentrations of AuNPs are safe for terrestrial isopods. We encourage reporting the results showing no adverse effects of nanoparticles to balance the prevailing publication of their adverse effects. This will help to build a realistic public perception of the environmental risk of nanomaterials.
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33

Durán-Meza, Ana L., Martha I. Escamilla-Ruiz, Xochitl F. Segovia-González, Maria V. Villagrana-Escareño, J. Roger Vega-Acosta, and Jaime Ruiz-Garcia. "Encapsidation of Different Plasmonic Gold Nanoparticles by the CCMV CP." Molecules 25, no. 11 (June 5, 2020): 2628. http://dx.doi.org/10.3390/molecules25112628.

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Different types of gold nanoparticles have been synthesized that show great potential in medical applications such as medical imaging, bio-analytical sensing and photothermal cancer therapy. However, their stability, polydispersity and biocompatibility are major issues of concern. For example, the synthesis of gold nanorods, obtained through the elongated micelle process, produce them with a high positive surface charge that is cytotoxic, while gold nanoshells are unstable and break down in a few weeks due to the Ostwald ripening process. In this work, we report the self-assembly of the capsid protein (CP) of cowpea chlorotic mottle virus (CCMV) around spherical gold nanoparticles, gold nanorods and gold nanoshells to form virus-like particles (VLPs). All gold nanoparticles were synthesized or treated to give them a negative surface charge, so they can interact with the positive N-terminus of the CP leading to the formation of the VLPs. To induce the protein self-assembly around the negative gold nanoparticles, we use different pH and ionic strength conditions determined from a CP phase diagram. The encapsidation with the viral CP will provide the nanoparticles better biocompatibility, stability, monodispersity and a new biological substrate on which can be introduced ligands toward specific cells, broadening the possibilities for medical applications.
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34

Cingarapu, Sreeram, Myles A. Ikenberry, Dambar B. Hamal, Christopher M. Sorensen, Keith Hohn, and Kenneth J. Klabunde. "Transformation of Indium Nanoparticles to β-Indium Sulfide: Digestive Ripening and Visible Light-Induced Photocatalytic Properties." Langmuir 28, no. 7 (February 9, 2012): 3569–75. http://dx.doi.org/10.1021/la203624p.

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35

Hillyer, J. F., and R. M. Albrecht. "Correlative Neutron Activation and TEM to Determine the Uptake Mechanism and Distribution of Orally Administered Colloidal Gold Nanoparticles." Microscopy and Microanalysis 6, S2 (August 2000): 1006–7. http://dx.doi.org/10.1017/s1431927600037521.

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The uptake of insoluble, particulate matter through the digestive tract occurs in low quantities, and the pathway and amount of particle uptake is size dependent. Previous studies have shown that the uptake of nanoparticles occurs mainly through the Peyer's patch regions of the small intestine while micrometer sized particles enter the body by a process called persorption: the paracellular uptake of microparticles from the digestive tract into the body. These studies have also shown that translocation is largely dependent on particle size: smaller particles are more readily absorbed. Research on the use of microparticles for the oral delivery of drugs, vaccines, and DNA have shown that protein, polysaccharide, and DNA microparticle encapsulation can increase uptake and bioavailability of absorbed molecules. All of these studies have used particles with diameters ranging from 0.1 to 10 μm. Metallic colloidal gold particles can be synthesized in sizes much smaller than micro- and nanoparticles currently being tested for drug delivery.
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36

Griffin, Fionn, and Donald Fitzmaurice. "Preparation and Thermally Promoted Ripening of Water-Soluble Gold Nanoparticles Stabilized by Weakly Physisorbed Ligands." Langmuir 23, no. 20 (September 2007): 10262–71. http://dx.doi.org/10.1021/la061261a.

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37

Seth, Jhumur, and Bhagavatula L. V. Prasad. "Bromide ion mediated modification to digestive ripening process: Preparation of ultra-small Pd, Pt, Rh and Ru nanoparticles." Nano Research 9, no. 7 (May 10, 2016): 2007–17. http://dx.doi.org/10.1007/s12274-016-1091-0.

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38

Talarska, Patrycja, Maciej Boruczkowski, and Jakub Żurawski. "Current Knowledge of Silver and Gold Nanoparticles in Laboratory Research—Application, Toxicity, Cellular Uptake." Nanomaterials 11, no. 9 (September 21, 2021): 2454. http://dx.doi.org/10.3390/nano11092454.

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Silver and gold nanoparticles can be found in a range of household products related to almost every area of life, including patches, bandages, paints, sportswear, personal care products, food storage equipment, cosmetics, disinfectants, etc. Their confirmed ability to enter the organism through respiratory and digestive systems, skin, and crossing the blood–brain barrier raises questions of their potential effect on cell function. Therefore, this manuscript aimed to summarize recent reports concerning the influence of variables such as size, shape, concentration, type of coating, or incubation time, on effects of gold and silver nanoparticles on cultured cell lines. Due to the increasingly common use of AgNP and AuNP in multiple branches of the industry, further studies on the effects of nanoparticles on different types of cells and the general natural environment are needed to enable their long-term use. However, some environmentally friendly solutions to chemically synthesized nanoparticles are also investigated, such as plant-based synthesis methods.
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39

Adokoh, Christian K., Frankline K. Keter, Collins Obuah, Henok H. Kinfe, Robert Tshikhudo, and James Darkwa. "Glyco disulfide capped gold nanoparticle synthesis: cytotoxicity studies and effects on lung cancer A549 cells." Future Medicinal Chemistry 14, no. 5 (March 2022): 307–24. http://dx.doi.org/10.4155/fmc-2021-0165.

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Background: Glyco disulfide gold nanoparticles (GDAuNPs) were prepared by three methods: direct, photochemical irradiation and ligand substitution. Glyco disulfide acted as reducing and capping agents of gold ions, to produce AuNPs GD1–GD16. Results: Shorter chains of glyco disulfides (n = 1 and 2) offered monodispersed and stable GDAuNPs in physiological pH, while longer chains (n = 3) furnished unstable nanoparticles. ζ-potential study of direct method GDAuNPs revealed surface charge dependency on the alkyl unit length. Transmission electron microscope imaging indicated that sizes/shapes of the ligand exchange AuNPs remained post-exchange step. The mechanism of GDAuNP formation was forecast as the Ostwald ripening effect at low pH of ligand (5.1-8.9) and reinforcement of static stabilization at high pH (12.4–13.0). Conclusion: GDAuNPs recorded moderately anticancer activity against the A549 cancer cell line, with IC50 between 14.95 and 64.95 μg/ml.
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40

Yang, Yun, Ya Yan, Wei Wang, and Jinru Li. "Precise size control of hydrophobic gold nanoparticles using cooperative effect of refluxing ripening and seeding growth." Nanotechnology 19, no. 17 (March 25, 2008): 175603. http://dx.doi.org/10.1088/0957-4484/19/17/175603.

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41

Saware, Kantrao, Ravindra Mahadappa Aurade, P. D. Kamala Jayanthi, and Venkataraman Abbaraju. "Modulatory Effect of Citrate Reduced Gold and Biosynthesized Silver Nanoparticles on α-Amylase Activity." Journal of Nanoparticles 2015 (June 23, 2015): 1–9. http://dx.doi.org/10.1155/2015/829718.

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Amylase is one of the important digestive enzymes involved in hydrolysis of starch. In this paper, we describe a novel approach to study the interaction of amylase enzyme with gold nanoparticles (AuNPs) and silver nanoparticles (AgNPs) and checked its catalytic function. AuNPs are synthesized using citrate reduction method and AgNPs were synthesized using biological route employing Ficus benghalensis and Ficus religiosa leaf extract as a reducing and stabilizing agent to reduce silver nitrate to silver atoms. A modulatory effect of nanoparticles on amylase activity was observed. Gold nanoparticles are excellent biocompatible surfaces for the immobilization of enzymes. Immobilized amylase showed 1- to 2-fold increase of activity compared to free enzyme. The biocatalytic activity of amylase in the bioconjugate was marginally enhanced relative to the free enzyme in solution. The bioconjugate material also showed significantly enhanced pH and temperature stability. The results indicate that the present study paves way for the modulator degradation of starch by the enzyme with AuNPs and biogenic AgNPs, which is a promising application in the medical and food industry.
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42

Vasile, E., A. Serafim, D. Petre, D. Giol, P. Dubruel, H. Iovu, and I. C. Stancu. "Direct Synthesis and Morphological Characterization of Gold-Dendrimer Nanocomposites Prepared Using PAMAM Succinamic Acid Dendrimers: Preliminary Study of the Calcification Potential." Scientific World Journal 2014 (2014): 1–15. http://dx.doi.org/10.1155/2014/103462.

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Gold-dendrimer nanocomposites were obtained for the first time by a simple colloidal approach based on the use of polyamidoamine dendrimers with succinamic acid terminal groups and dodecanediamine core. Spherical and highly crystalline nanoparticles with dimensions between 3 nm and 60 nm, and size-polydispersity depending on the synthesis conditions, have been generated. The influence of the stoichiometric ratio and the structural and architectural features of the dendrimers on the properties of the nanocomposites has been described. The self-assembling behaviour of these materials produces gold-dendrimer nanostructured porous networks with variable density, porosity, and composition. The investigations of the reaction systems, by TEM, at two postsynthesis moments, allowed to preliminary establish the control over the properties of the nanocomposite products. Furthermore, this study allowed better understanding of the mechanism of nanocomposite generation. Impressively, in the early stages of the synthesis, the organization of gold inside the dendrimer molecules has been evidenced by micrographs. Growth and ripening mechanisms further lead to nanoparticles with typical characteristics. The potential of such nanocomposite particles to induce calcification when coating a polymer substrate was also investigated.
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43

Mohammed, Mohammed Subhi, Ban H. Adil, A. S. Obaid, and Ahmed Majeed Al-Shammari. "Plasma Jet Prepared Gold and Silver Nanoparticles to Induce Caspase-Independent Apoptosis in Digestive System Cancers." Materials Science Forum 1050 (January 18, 2022): 51–63. http://dx.doi.org/10.4028/www.scientific.net/msf.1050.51.

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Alot of medical and industrial applications used the metal nanoparticles (NPs) with increase interest to be used as cancer therapy. The current work aimed to prepare AuNPs and AgNPs through the use of plasma jet and test their antitumor mechanism of apoptosis induction. The results indicating the face-centered cubic structures and crystalline nature of AuNPs and AgNPs. Also, the image of FESEM showed that the well dispersions regarding AuNPs and AgNPs, while the NP’s spherical shape with the particle size distributions which are considered to be close that estimated from the XRD. cytotoxicity have been assessed against the Normal embryonic cell line REF and the digestive system (HC , SK-GT-4) cell lines under a variety of the series dilute of the Ag and Au NPs (6.25, 12.5, 25, 50 and 100%), have been determined through a microtetrazolium (MTT) assay. The capacity of Ag and Au NPs to induce apoptosis to an infected cell has been studied by crystal violet stain to measure the percentage of induction of apoptosis. In cases where 100 μg\ml Au NP concentrations are 69.60 percent, the maximum cytotoxicity of the HC cell line was reported, while 100 μg\ml Au NP was 69.20% for the SKg cell line exposure. qRT-PCR in AuNPs and AgNPs treated of (HC and SKG) cell lines revealed a remarkable in the expression of BAX, BCL2 and AIF, Endo G (independent pathway).
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44

Sanyal, Udishnu, Ranjan Datta, and Balaji R. Jagirdar. "Colloidal calcium nanoparticles: digestive ripening in the presence of a capping agent and coalescence of particles under an electron beam." RSC Adv. 2, no. 1 (2012): 259–63. http://dx.doi.org/10.1039/c1ra00468a.

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45

Schmitt, Julien, Stéphanie Hajiw, Amélie Lecchi, Jéril Degrouard, Anniina Salonen, Marianne Impéror-Clerc, and Brigitte Pansu. "Formation of Superlattices of Gold Nanoparticles Using Ostwald Ripening in Emulsions: Transition from fcc to bcc Structure." Journal of Physical Chemistry B 120, no. 25 (June 21, 2016): 5759–66. http://dx.doi.org/10.1021/acs.jpcb.6b03287.

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Wu, Chenshuo, Hongpeng He, Yahui Song, Cuixia Bi, Lixiang Xing, Wei Du, Shenggang Li, and Haibing Xia. "Synthesis of large gold nanoparticles with deformation twinnings by one-step seeded growth with Cu(ii)-mediated Ostwald ripening for determining nitrile and isonitrile groups." Nanoscale 12, no. 32 (2020): 16934–43. http://dx.doi.org/10.1039/d0nr04733c.

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47

Smetana, Alexander B., Kenneth J. Klabunde, and Christopher M. Sorensen. "Synthesis of spherical silver nanoparticles by digestive ripening, stabilization with various agents, and their 3-D and 2-D superlattice formation." Journal of Colloid and Interface Science 284, no. 2 (April 2005): 521–26. http://dx.doi.org/10.1016/j.jcis.2004.10.038.

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48

Garcés, Víctor, Ana González, Laura Sabio, Carmen M. Sánchez-Arévalo, Natividad Gálvez, and José M. Dominguez-Vera. "Magnetic and Golden Yogurts. Food as a Potential Nanomedicine Carrier." Materials 13, no. 2 (January 19, 2020): 481. http://dx.doi.org/10.3390/ma13020481.

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Yogurt is one of the most emblematic and popular fermented foods. It is produced by the fermentation of milk lactose by bacteria such as Streptococcus thermophilus and Lactobacillus acidophilus. Magnetic (MNPs) and gold nanoparticles (AuNPs) were incorporated into the exopolysaccharides (EPSs) of these bacteria. The functionalized bacteria were characterized by UV-vis spectroscopy and transmission electron microscopy. A large number of MNPs and AuNPs were bound to the bacterial EPS. Interestingly, the nanoparticles’ (NPs) presence did not affect the bacteria’s capacity to ferment milk and to produce magnetic and golden yogurts. Magnetic and golden yogurts represent the perfect combination of emblematic food and nanoparticles and have a range of potential biomedical applications: use in iron-deficiency anemia, diagnosis and hyperthermia treatment of appropriate digestive diseases, and interest in glamour cuisine.
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Bhaskar, Srilakshmi P., Megha Vijayan, and Balaji R. Jagirdar. "Size Modulation of Colloidal Au Nanoparticles via Digestive Ripening in Conjunction with a Solvated Metal Atom Dispersion Method: An Insight Into Mechanism." Journal of Physical Chemistry C 118, no. 31 (July 28, 2014): 18214–25. http://dx.doi.org/10.1021/jp505121b.

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Bastús, Neus G., Joan Comenge, and Víctor Puntes. "Kinetically Controlled Seeded Growth Synthesis of Citrate-Stabilized Gold Nanoparticles of up to 200 nm: Size Focusing versus Ostwald Ripening." Langmuir 27, no. 17 (September 6, 2011): 11098–105. http://dx.doi.org/10.1021/la201938u.

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