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Journal articles on the topic 'Gongronema latifolium'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Johnkennedy, Nnodim, Chinedu-Madu Jane Ugochi, Nwaokoro Joakin Chidozie, Bede-Ojimadu Onyinyechi Ogechi, and Ezekwesiri Cletus. "Effects of Gongronema latifolium Leaf Extract on Malondialdehyde Concentration of Wistar Rats Administered With a Toxic Dose of Ibuprofen." Sumerianz Journal of Biotechnology, no. 41 (January 23, 2021): 1–3. http://dx.doi.org/10.47752/sjb.41.1.3.

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Aim: To determine effects of Gongronema latifolium leaf extract on Malondialdehyde (MDA) levels of wistar rats induced by a toxic dose of Ibuprofen. Material and Methods: Thirty wistar rats were randomly divided into five groups with six rats in each group (n=6); Control (C) received normal feed only. T1 was administered with Gongronema latifolium leaf extract 50 mg/kg BW+ Ibuprofen, T2: Gongronema latifolium extract 100 mg/kg BW+ Ibuprofen, T3: Gongronema latifolium leaf extract 150 mg/kg BW+ Ibuprofen. T4: received Jbruprofen only.This lasted for fourteen days. On the 15th day, blood samples

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Eboh, Abraham Sisein, Owabhel Faith Robert, Azibanasamesa Dumaro Charles Owaba, and Ebizimor Wodu. "GC-MS Analysis of Medicinal Compounds and Reactive Oxygen Species Scavenging Properties of Gongronema Latifolium (Utazi) n-Hexane Extract." Pharmaceutical and Chemical Journal 10, no. 1 (2023): 37–42. https://doi.org/10.5281/zenodo.13983560.

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<em>Gongronema latifolium </em>(Amaranth globe) is popularly known for its nutritional and health promoting values. This plant is widely found in the southern part of Nigeria and is used in local dishes and also for Medicinal purposes. In this project the essential Medicinal and nutritive compounds were detected using GC-MS analysis. The leaves of <em>Gongronema latifolium </em>were dried and extracted with n-hexane. The dry paste was subjected to GC-MS analysis. Various Medicinal and nutritive compounds were detected which included 1,5-diisopropyl-2,3-dimethylcyclohexane, 2,5-bis(1-methyl pro

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Faith Robert Owabhel and Abraham Sisein Eboh. "Bioactive compounds from GC-MS analysis in methanolic extract of Gongronema latifolium inhibits aluminium chloride induced oxidative stress in rat spermatozoa in vitro." International Journal of Frontiers in Science and Technology Research 2, no. 2 (2022): 031–35. http://dx.doi.org/10.53294/ijfstr.2022.2.2.0039.

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This study investigated the effect of Gongronema latifolium extract on aluminum chloride-induced sperm oxidative stress. Spermatozoa were obtained from the epidydimis and dispersed in a buffer consisting of tris-(hydroxymethyl)-aminomethane, citric acid anhydrous and D (−) fructose (TCF buffer) and incubated with Gongronema latifolium alone (0.8 mg/ml), AlCl3 alone (50 mM) and Gongronema latifolium (0.2 – 0.8 mg/ml) + AlCl3 (50 mM) repectively, for 3 h at 32 0C. We found that exposure to aluminum chloride alone led to significant increase in lipid peroxidation (LP) 14.41±1.18µM and protein car

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4

Omodamiro O.D., Alaebo P.O., Olukotun B.G., and Chikezie P.C. "Evaluation of hepatotoxicity effect of methanol leave extract of Gongronema latifolium in Albino rats." World Journal of Advanced Pharmaceutical and Life Sciences 1, no. 1 (2021): 014–22. http://dx.doi.org/10.53346/wjapls.2021.1.1.0017.

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Gongronema latifolium is highly medicinal in nature. The fundamental ingredients used for medicinal purposes are stored in the various parts of the plant such as the fruits, seeds, leaves, root and stem. This present study is aimed to evaluate the hepatotoxicity effect of methanolic leaf extract of Gongronema latifolium on albino rats. This study was divided into five groups normal control groups: received commercial rat feed and water, group 2: received 1000 mg/kg b.w. of leaf extract of Gongronema latifolium, group 3: received 500 mg/kg b.w of leaf extract of G. latifolium, group 4; received

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Ogbonna, Grace, Rabiu Magaji, and Sherif Isa. "THE EFFECTS OF METHANOLIC LEAF EXTRACT OF GONGRONEMA LATIFOLIUM ON MILK YIELD AND SOME LACTOGENIC HORMONES IN LACTATING WISTAR RATS." FUDMA JOURNAL OF SCIENCES 6, no. 2 (2022): 58–62. http://dx.doi.org/10.33003/fjs-2022-0602-771.

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Proper and exclusive breastfeeding is recommended during the early infancy stage of a child. Lactation insufficiency serves as a hinderance to this. Gongronema latifolium is an important medicinal plant known for its various therapeutic effects. The lactogenic effects of Gongronema latifolium used locally to boost lactation was investigated. Twenty Wistar dams were grouped into five groups (n=4); consisting of control group (1 ml/kg distilled water), standard drug group (metoclopramide 5 mg/kg), 200 mg /kg, 400 mg/kg and 800 mg/kg Gongronema latifolium methanolic extract groups. The pups were

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Usunobun, Usunomena, and V. Chinwe Igwe. "Analysis of phytochemicals, minerals and in vitro antioxidant activities of Gongronema latifolium leaves." International Journal of Trend in Scientific Research and Development 1, no. 4 (2017): 35–39. https://doi.org/10.31142/ijtsrd87.

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Gongronema latifolium is primarily used as spice and vegetable as well as a herb in traditional medicine in the treatment of malaria, diabetes and hypertension. This study is aimed at providing in vitro laboratory knowledge on Gongronema latifolium leaves.Methods Minerals were analyzed using Atomic Absorption Spectrophotometer while phyto nutrients were screened using standard laboratory procedures. 2,2 diphenyl 1 picrylhydrazyl DPPH radical scavenging and reducing power activities were determined spectrophotometrically. Usunobun Usunomena | Igwe V. Chinwe "Analysis of phytochemicals, min

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Igbokwe, Nwamaka, Abubakar A. Abubakar, Bukola A. Oseni, and Bryan Okwuba. "Psidium guajava Linn and Gongronema latifolium Benth Leaves Exhibit Potential Antimicrobial Therapeutics Against Some Clinical Pathogens." Pan African Journal of Life Sciences 8, no. 2 (2024): 206–13. http://dx.doi.org/10.36108/pajols/4202/80.0290.

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Background: The proliferation of antimicrobial resistance against synthetic pharmaceutical compounds highlights an exigent need to explore natural reservoirs to discover novel antimicrobial therapeutic agents. This study investigates the antimicrobial effectiveness of methanolic extracts obtained from Psidium guajava and Gongronema latifolium leaves. Methods: The coarse powder of dried leaves from Psidium guajava and Gongronema latifolium was subjected to cold maceration using 95% and 70% methanol to extract their phytonutrients. Utilizing the agar-well diffusion method, the antimicrobial susc

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Chinedu, Imo, O. Uhegbu Friday, Nkeiruka G. Ifeanacho, Otito Egbeigwe, and A. S. Ezekwe. "Biochemical and histological changes associated with methanolic leaf extract of Gongronema latifolium in acetaminophen-induced hepatic toxicity in wistar albino rats." International Journal of Biomolecules and Biomedicine (IJBB) 4, no. 2 (2014): 1–7. https://doi.org/10.5281/zenodo.8303762.

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This study examined the biochemical and histological changes associated with methanolic leaf extract of <em>Gongronema latifolium</em> in acetaminophen-induced hepatic toxicity in wistar albino rats. The serum liver enzymesALT, AST and ALP decreased significantly (p<0.05) in the test animals treated with 600mg/kg of the leaf extract. Protein concentration increased significantly (p<0.05) in the test animals treated with 600mg/kg of the leaf extract.The effect of the <em>G. latifolium</em> leaf extract seems to be dose dependent on the liver enzymes and protein concent

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Beshel, Justin Atiang, Favour Nyoh Beshel, and Clement Oshie Nku Daniel Udofia Owu. "Gongronema Latifolium: A Plant with Cardioprotective Potentials." International Journal of Trend in Scientific Research and Development Volume-3, Issue-2 (2019): 548–58. http://dx.doi.org/10.31142/ijtsrd21431.

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Uzor, S., U. E. Godwin, I. Uzor, et al. "The synergistic effect of <i>Ocimum gratissimum</i> and <i>Gongronema latifolium</i> extracts on lipid profile of hyperlipidemic induced rats." Nigerian Journal of Biotechnology 41, no. 2 (2025): 140–48. https://doi.org/10.4314/njb.v41i2.13.

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Accumulation of excess fat has great adverse health implications, including tissue damage and disorders affecting the liver, brain, bone marrow, and other vital organs. Cardiovascular diseases are known to be strongly associated with increased level of blood lipids. To mitigate this risk, there is a growing interest in exploring natural interventions, such as herbal extracts. This study aimed to evaluate the synergistic effects of Ocimum gratissimum and Gongronema latifolium extracts on the lipid profile of hyperlipidemic rats, addressing the increasing concern of hyperlipidemia-related health

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Kayode, Dasofunjo, Timothy Francisca M, Eyam John A, et al. "Haematinic and immunomodulatory effects of leaf extract of gongronema latifolium following the onslaught of mucosa ulceration in wistar rats." Global Journal of Pure and Applied Sciences 29, no. 1 (2023): 49–54. http://dx.doi.org/10.4314/gjpas.v29i1.6.

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Helicobacter pylori (H. pylori) infection is a global public health problem; a higher burden of the infection was reported in developing countries including Nigeria and Cameroun. It has been associated with several gastrointestinal diseases, and recently implicated with some haematological abnormalities. This research was carried out to determine the effect of ethanol extract of Gongronema latifolium on haematological parameters of ulcerated Wistar rats.. The experiment was carried out on thirty-six (36) healthy male Wistar rats of weight ranges from (180-200) g. The rats were divide into six

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Ekozin, A. A., O. B. Isola, O. C. Inetianbor, S. O. Omondiale, R.T Omojoyegbe, and T. S. Okanlawon. "Green Synthesized Iron Nanoparticles Using Gongronema latifolium Leaf Extract: Characterization, Antioxidant, and Antidiabetic Activities." GVU Journal of Science, Health and Technology 9, no. 1 (2024): 137–49. https://doi.org/10.5281/zenodo.13296786.

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ABSTRACTGreen nanoparticles are derived from natural sources possessing unique properties for biomedical applications.Inhibition of key enzymes (-amylase and -glucosidase) involved in the digestion of starch and protection againstfree radicals and lipid peroxidation could be part of the therapeutic approach towards the management ofhyperglycemia. The study was carried out to synthesize and characterize Iron Oxide nanoparticles coatedwith ethanolic leaf extracts of Gongronema latifolium (Gl-FeONPs) using highly advanced techniques for itsuse as antioxidant and antidiabetic. The study compared t

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Daniel Ikechukwu Oraekei, Chukwuka Benjamin Uzodinma, Uchechukwu Harrison Orji, et al. "Evaluation of the anti-inflammatory, anti-ulcer and gastric histopathology activities of ethanol leaf extracts of Gongronema latifolium in diclofenac induced albino rat models." World Journal of Advanced Research and Reviews 21, no. 3 (2024): 182–91. http://dx.doi.org/10.30574/wjarr.2024.21.3.0624.

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The stomach is the roomiest portion of gastrointestinal tract. It serves as a reservoir for ingested food, secrets enzymes and hydrochloric acid for digestion of foods. This study was aimed at evaluating the anti-ulcer activity of ethanol leaf extracts of Gongronema latifolium in diclofenac induced albino rat models. G. latifolium leaves powder (1600 g) was weighed and extracted by cold maceration for 72 hours in 15 L of ethanol. Qualitative phytochemical analysis and acute toxicity study of the extract were done. Anti-inflammatory activities of the extract were tested on both heat and hypo to

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14

Mbosowo M., Etukudo, and Osim Samuel E. "Development Indices of Gongronema latifolium Benth Domesticated in Otuoke Terrestrial Habitat, Bayelsa State, Nigeria." European Scientific Journal, ESJ 14, no. 24 (2018): 1. http://dx.doi.org/10.19044/esj.2018.v14n24p1.

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The effects of physico-chemical properties of two soil sampling locations on the proximate and mineral nutrients contents of Gongronema latifolium Benth were examined in Otuoke secondary forest habitat, in Bayelsa State, Nigeria. Leaf samples of Gongronema latifolium and soil (0-20 cm depth) samples were randomly collected from two sites in the study area. Three replicates were maintained for each treatment using randomized complete block design. The pH of 5.10 was recorded at location 1 while that of location 2 was 5.00. The contents of calcium, magnesium, sodium, phosphorus, iron, copper and

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Ujong, Gabriel Otu, Justin Atiang Beshel, Nkanu Etah Etah, Ofem Effiong Ofem, and Idara Asuquo Okon. "Hepato and Nephro-protective Potentials of Gongronema latifolium in Streptozotocin Induced diabetic Rat Model." Journal of Drug Delivery and Therapeutics 12, no. 5 (2022): 70–79. http://dx.doi.org/10.22270/jddt.v12i5.5623.

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Gongronema latifolium (GL) is reported to have hepato-protective and nephron-protective ability. Diabetes is associated with liver and kidney damage. This work was designed to evaluate the effect of ethanolic leaf extract of Gongronema latifolium on liver and kidney functions in Streptozotocin-induced diabetic rats. 40 Wistar rats of both sexes (150g-200g) were divided into five (n=8). Group 1- normal control (received normal saline placebo orally). Group 2 received 200mg/kg GL orally. Group 3 was the diabetic group administered 65mg/kg of streptozotocin (STZ) intraperitoneally for two consecu

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Adeyemi-Doro, Abimbola Abiodun, Sule Ola Salawu, and Akintunde Afolabi Akindahunsi. "Effects of Gongronema latifolium Benth and Celosia argentea Linn supplemented diet on the hepatic and cardiac functions of high-fat diet-induced hyperlipidemic rats." Nutrition & Food Science 52, no. 3 (2021): 534–46. http://dx.doi.org/10.1108/nfs-03-2021-0099.

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Purpose The purpose of this study is to assess the effects of two green leafy vegetables (Gongronema latifolium and Celosia argentea) on the hepatic biomarkers [Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST)], cardiac biomarkers [Creatine Kinase (CK) and Lactate Dehydrogenase (LDH)] and histopathology of the heart of high-fat diet-induced hyperlipidemic rats, with the aim of evaluating the vegetables as functional foods. Design/methodology/approach Experimental diets consisted of Control Diet (CD), High-Fat Diet (HFD), High-Fat Diet with Blanched Celosia argentea (HCB), Hi

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Daniel, Ikechukwu Oraekei, Benjamin Uzodinma Chukwuka, Harrison Orji Uchechukwu, et al. "Evaluation of the anti-inflammatory, anti-ulcer and gastric histopathology activities of ethanol leaf extracts of Gongronema latifolium in diclofenac induced albino rat models." World Journal of Advanced Research and Reviews 21, no. 3 (2024): 182–91. https://doi.org/10.5281/zenodo.14050128.

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The stomach is the roomiest portion of gastrointestinal tract. It serves as a reservoir for ingested food, secrets enzymes and hydrochloric acid for digestion of foods. This study was aimed at evaluating the anti-ulcer activity of ethanol leaf extracts of <em>Gongronema latifolium</em> in diclofenac induced albino rat models. <em>G. latifolium</em> leaves powder (1600 g) was weighed and extracted by cold maceration for 72 hours in 15 L of ethanol. Qualitative phytochemical analysis and acute toxicity study of the extract were done. Anti-inflammatory activities of the extrac

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Osuagwu, Olachi Lilian, Chidi Uzoma Igwe, Chiamaka Perpetua Nzebude, Onyinyechi Chijioke Njoku, and Juliet Chioma Ejiofor. "Phenolic Profile and Antioxidant Potential of Aqueous Extracts of Selected Traditional Anti-cough Plants." Journal of Drug Delivery and Therapeutics 13, no. 7 (2023): 22–29. http://dx.doi.org/10.22270/jddt.v13i7.6124.

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The recent surge in attention towards plant-based antioxidants can be attributed to their perceived advantageous impact on human health. The present study assessed the phenolic profile, antioxidant potential, and free radical scavenging ability of hot aqueous leaf extracts obtained from Vernonia amygdalina, Piper guineense, and Gongronema latifolium. High-Performance Liquid Chromatography (HPLC) was used to examine phenolic profile. Antioxidant capacity was conducted using total flavonoid content (TFC), total phenol content (TPC), total antioxidant capacity (TAC), polyphenol oxidase (PPO) acti

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Gbadamosi, I. T., and A. O. Kalejaye. "Traditional soups in Nigeria: A review of six botanicals." Nigerian Journal of Natural Products and Medicine 23 (May 13, 2020): 22–32. http://dx.doi.org/10.4314/njnpm.v23i1.4.

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Ethnobotanical investigations by workers have revealed the use of juvenile leaves of Cissus populnea L. (ogbolo), Sesamum indicum L. (eeku),Gongronema latifolium Benth. (Madunmaro), Mangifera indica L. (Mongoro), Ipomoea batatas (L.) Lam. (Odunkun) and Ceiba pentandra (L.) Gaertn. (Araba) for preparing soups in Nigeria. In spite of this, the consumption of these traditional soups seems to be abandoned and only consumed during scarcity of commonly used vegetables such as Corchorus olitorius L. (Ewedu). Certain traditional soups are associated with particular Nigerian ethnic groups. As examples,

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20

U. L., Undie, Agba O. A, Adiaha M. S, and Osang P. O. "Responses of Utasi (Gongronema latifolium) to NPK 15:15:15 Fertilizer Rates in a Utisol South-South Nigeria." International Journal of Scientific World 5, no. 2 (2017): 126. http://dx.doi.org/10.14419/ijsw.v5i2.8112.

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Gongronema latifolium (Benth) called Utasi by Igbos and Arokeke by Yorubas belongs to Ascepiadaceae family. It is an herbaceous climbing plant found in the tropical region. The leaves are used for food, culinary, medicinal and other domestic purposes. The plant is found among the wild and is not cultivated in regular farms. It is one of the endanger species that stands the risk of been extinct. Therefore, the study was carried out to determine the responses of Gongronema latifolium to seven rates of NPK 15:15:15 fertilizer during 2014 and 2015 cropping seasons at the Teaching and Research Farm

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Justin, Atiang Beshel, Nyoh Beshel Favour, and Oshie Nku |. Daniel Udofia Owu Clement. "Gongronema Latifolium A Plant with Cardioprotective Potentials." International Journal of Trend in Scientific Research and Development 3, no. 2 (2019): 548–58. https://doi.org/10.31142/ijtsrd21431.

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Gongronema latifolium GL has gained research interest in the field of Medicine. The present study investigated the cardioprotective potentials of the ethanolic and ethyl acetate fraction of the leaves extract of G.L. 18 Male Wistar rats were divided equally into three groups. Group 1 was the control group, and was administered 0.9 normal saline. Group 2 was administered 200mg kg ethanolic leaves extract of GL. Group 3 received 200mg kg ethyl acetate fraction of the leaves extract of GL. Administration was via oral gavage and lasted for 14 days. The rats were sacrificed under chloroform anaesth

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Ojo, F. T., O. A. Idowu, K. O. Ademolu, and J. O. Olukunle. "In vivo anthelmintic potentials of Gongronema latifolium and Picralima nitida against gastrointestinal parasite (Heligmosomoides bakeri)." Helminthologia 60, no. 4 (2023): 336–47. http://dx.doi.org/10.2478/helm-2023-0033.

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Summary Gastrointestinal parasites which are responsible for soil-transmitted helminthiases cause illness globally. The control of helminthiasis depends on mass distribution of anthelmintics which has been reported for its resistance, toxicity and low efficacy. In this study, anthelmintic potentials of Gongronema latifolium and Picralima nitida which have wide application in traditional medicine were determined in vivo using Heligmosomoides bakeri a naturally occurring gastro-intestinal parasite of rodents that is closely related to highly prevalent human nematode parasites. Extracts of P. nit

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Eleyinmi, Afolabi F. "Chemical composition and antibacterial activity of Gongronema latifolium." Journal of Zhejiang University SCIENCE B 8, no. 5 (2007): 352–58. http://dx.doi.org/10.1631/jzus.2007.b0352.

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E, Balogun, Besong E, Obimma N, and Mbamalu A. "Gongronema Latifolium: A Phytochemical, Nutritional and Pharmacological Review." Journal of Physiology and Pharmacology Advances 6, no. 1 (2016): 811. http://dx.doi.org/10.5455/jppa.1969123104000.

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Ugbaja, R. A. E., and N. Onuora. "Agro-Techniques for Possible Domestication of Gongronema Latifolium." East African Agricultural and Forestry Journal 60, no. 4 (1995): 255–60. http://dx.doi.org/10.4314/eaafj.v60i4.46783.

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Morebise, Olugbenga, Michael A. Fafunso, J. Modupe Makinde, Olumayokun A. Olajide, and E. O. Awe. "Antiinflammatory property of the leaves of Gongronema latifolium." Phytotherapy Research 16, S1 (2002): 75–77. http://dx.doi.org/10.1002/ptr.784.

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Anameze, C. I., I. O. Emmy-Egbe, L. C. Anyaegbunam, et al. "Qualitative and Quantitative Phytochemical Analysis of Gongronema latifolium Leaf Extract." IPS Journal of Applied Microbiology and Biotechnology 2, no. 1 (2023): 16–19. http://dx.doi.org/10.54117/ijamb.v2i1.10.

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Phytochemical compounds are secondary metabolites produced by plants in which some have medicinal uses. The aim of this study is to qualitatively and quantitatively analyze the phytochemical composition of G. latifolium leaf extract. Fresh and healthy leaves of the medicinal plant of G. latifolium leaf were harvested, washed thoroughly in distilled water and dried at room temperature for 7 days. The dried leaf was milled to fine powder. The pulverized plant was weighed and used for the phytochemical analysis. Based on qualitative analysis, the results show the presence of tannins, alkaloids, s

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Adeniran, Adedapo Adedayo, Emmanuel Adeyanju, and Nneka Kingslena Okeke. "Anatomical characterization and physicochemical standardization of Gongronema latifolium Benth. (Apocynaceae)." Journal of Pharmacy & Bioresources 19, no. 1 (2022): 16–23. http://dx.doi.org/10.4314/jpb.v19i1.3.

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Gongronema latifolium Benth belongs to the family Apocynaceae. Generally, the leaves and stems of G. latifolium are used as medicine and spices for sauces, soups and salads in Southern Nigeria. In view of its medicinal uses, the present study aimed at documenting anatomical characters and physicochemical properties for its standardization. The leaf epidermis, transverse section of the midrib, petiole and stem were prepared using standard procedures. Physicochemical properties of the powdered plant were conducted following standard methods. The leaf epidermal layer revealed anomocytic stomata,

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Nwakpa, J. N., E. E. Oti, and M. U. Agim. "Toxicity of aquaeous leaf extracts of Gongronema latifolium on behaviourial and haematological characteristics of Clarias gariepinus (Burchell, 1822) juveniles." Journal of Aquatic Sciences 35, no. 1 (2020): 19–28. http://dx.doi.org/10.4314/jas.v35i1.3.

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A static bioassay experiment was set up to investigate effects of acute (96-hrLC50) concentrations of aqueous leaf extracts of Gongronema latifolium on behaviourial and haematological characteristics of Clarias gariepinus (Burchell, 1822) juveniles. Evaluation of toxicity of leaf extracts at concentrations of: 0, 10, 25, 50, 75, and 100mg/l was done at various time intervals on the fish. A total of 180 catfish juveniles with average initial weight of 8.37±1.36g and total length of 12.10±2.45cm were used. The fish were distributed among the treatments on complete randomized design. Each treatme

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Ekong, MosesB, UbongU Ekpene, AgnesA Nwakanma, AniekanI Peter, and BasseyT Etuknwa. "Rauvolfia vomitoria and Gongronema latifolium stimulate cortical cell proliferations." Annals of Bioanthropology 4, no. 1 (2016): 41. http://dx.doi.org/10.4103/2315-7992.190464.

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Dasofunjo, K., and AA and Nku CI Asuk. "Evaluating the effect of ethanol leaf extract of Gongronema latifolium on some reproductive hormones of male Wistar rats." GSC Biological and Pharmaceutical Sciences 12, no. 3 (2020): 166–73. https://doi.org/10.5281/zenodo.4266024.

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This research was aimed at evaluating the effect of ethanol leaf extract of <em>Gongronema latifolium</em> on some reproductive hormones of male Wistar rats.  Eighteen (18) male Wistar rats weighing 120-200 g were divided into three (3) groups of six (6) animals each. The animals were allowed to undergo acclimatisation period for seven days before the start of the research. Animals in group A served as the control, while group B and C were administered 100 and 200 mg/kg body weight of ethanol extract of <em>G. latifolium,</em> respectively. The administration was perfo

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Egbuniwe, Maureen Ifeyinwa, Harrison Anezichukwu Ozoani, Amara Anwuchaepe Ajaghaku, Ikechukwu Sonne Mbagwu, Uchechukwu Harrison Orji, and Daniel Lotanna Ajaghaku. "Combination Interactive Effects of Gongronema latifolium Leaves and Picralima nitida Seeds Extracts on Glucose Tolerance." Biology, Medicine, & Natural Product Chemistry 12, no. 1 (2023): 259–66. http://dx.doi.org/10.14421/biomedich.2023.121.259-266.

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This study evaluated the combination interactive effects of G. latifolium leaves and P. nitida seed extracts using a metabolic glucose tolerance test. The plant samples were extracted separately using cold maceration and their acute toxicities were determined. Dose-response glucose tolerant tests of both plants were done using a 2 g/kg glucose load monitored over 0 – 1h. A 41% effect isobologram was used to determine the needed dose combinations according to the principle of Loewe’s additivity model. The glucose tolerant tests of dose pairs of the combined extracts were evaluated and their com

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Nyah, Nkereuwem U., James O. Effiong, Okon E. Okon, Ekemini J. Obosi, and Ukeme A. Essien. "Effects of Ethanol leaf extracts of Mangifera indica and Gongronama latifolium on some Haematological Parameters of Albino Wistar Rats." Asian Journal of Research in Biochemistry 13, no. 2 (2023): 1–6. http://dx.doi.org/10.9734/ajrb/2023/v13i2250.

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The effects of ethanol leaf extracts of Mangifera indica and Gongronema latifolium on some haematological parameters (Haematocrit, HCT; Mean corpuscular Haemoglobin concentration, MCHC; Neutrophils, NEUT; Red cell Distribution width, RDW; and mixed blood cell count, MXD) in albino wistar rats were evaluated. Sixteen animals (185-223g) were assigned four groups of four rats each. Groups 1 and 3 were treated with 200mg/kg Mangifera indica and Gongronama latifolium respectively. Group 2 was treated with 200mg/kg of both plant leaf extracts at 50:50 dosage ratio. Group 4 was not treated and

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SCHNEIDER, C., K. ROTSCHEIDT, and E. BREITMAIER. "ChemInform Abstract: Four New Pregnane Glycosides from Gongronema latifolium ( Asclepiadaceae)." ChemInform 25, no. 3 (2010): no. http://dx.doi.org/10.1002/chin.199403208.

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O, Ujong Gabriel, Beshel Justin A, Idara Asuquo Okon, and Owu Daniel D. "Ethanolic Leaf Extract of Gongronema Latifolium Prevents Depletion of Nitric Oxide and Anti-Oxidants Levels in Streptozotocin Induced Diabetic Rats." Der Pharma Chemica 14, no. 3 (2022): 6. https://doi.org/10.5281/zenodo.13354382.

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Lipid peroxidation is a major disorder that disrupts cellular integrity, resulting in many pathological conditions. This work was designed to evaluate the effect of ethanolic leaf extract of Gongronema latifolium (GL) on nitric oxide, anti-oxidants (SOD, total anti-oxidant capacity) and lipid peroxidation product (MDA) in Streptozotocin-induced diabetic rats. 40 Wistar rats of both sexes (150g-200g) were divided into 5 groups (n=8). Group 1 (control) received 1mL normal saline orally. Group 2 (GL) received 200 mg/kg b.wt. Of GL orally. Group 3 (DM) received 65mg/kg b.wt. of streptozotocin (STZ

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S., I. Okonkwo1* V. E. Mmuo2 E. C. Okafor3 V.O. Offiah4 C. K. Okonkwo5 P. O. Okwuego6 V. S. Okonkwo7 A. T. Kene-Okonkwo8. "Extraction, Fatty Acid Profile and Elemental Analysis of Gongronema latifolium (Utazi) Leaf." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1244–56. https://doi.org/10.5281/zenodo.15020463.

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Medicinal plants are well known support for traditional medicine system that are used to mitigate human diseases. The African continent and culture have provided evidence of the efficacy of indigenously grown plants as remedies against diseases. The effectiveness of these plants are as a result of the presence of secondary metabolites. In this study, the fatty acid profile, the active components and elemental (mineral) composition of Gongronema latifolium (Utazi) leaf were evaluated. Extraction was conducted using Ultrasound and Soxhlet extractor.The isolation and elemental compositions were d

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Okerulu, Adaobi Linda, Osah Martins Onwuka, and Godson Chukwuemeka Ajuzie. "Hepatic Enzymatic Activities of Di-Herbal Aqueous Extract of Ocimum gratissimum and Gongronema latifolium on Liver Dysfunction in Experimental Hyperglycemic Rats." Journal of International Research in Medical and Pharmaceutical Sciences 18, no. 2 (2023): 13–22. http://dx.doi.org/10.56557/jirmeps/2023/v18i28258.

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This study investigated the hepatic enzymatic activities of di-herbal aqueous extract of Ocimum gratissimum and Gongronema latifolium on liver dysfunction in experimental hyperglycemic rats. The animals were randomly assigned into; Group 1 – control, Group 2 – hyperglycemic control (diabetes induced and untreated), Group 3 – received 300 mg/kg of O. gratissimum extract, Group 4 – received 300 mg/kg of G. latifolium extract, Group 5 – received di-herbal extract of 150 mg/kg of O. gratissimum and 150 mg/kg of G. latifolium for 28 days. The results showed that experimental hyperglycemia induced l

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Otu, Ujong Gabriel, Beshel Justin Atiang, Nkanu Etah, and Ofem Ofem Effiong. "Attenuation of Fear and Anxiety Related Behaviours by Ethanolic Leaf Extract of Gongronema latifolium in Swiss Albino Mice." Saudi Journal of Medicine 7, no. 1 (2022): 45–51. http://dx.doi.org/10.36348/sjm.2022.v07i01.008.

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Anxiety disorders are serious medical illnesses that affect approximately 19 million American adults. To cope with anxiety, people employ potentially harmful strategies like alcohol, cigarettes, medication, withdrawal etc. which may cause panic disorder to worsen. Gongronema latifolium (GL) is one of the medicinal plants used in the treatment of ailment including mental disorders. This study was therefore aimed to elucidate effects of administration of ethanolic leaves extract of fear and anxiety using light/dark transition box. Thirty (30) adult male Swiss white mice were assigned into three

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Obijuru N.T., Nwaoguikpe R.N, Ene A.C., and Igwe C.U. "Characterization and biological activity of some anti-diabetic plants: Medicago sativa Gongronema latifolium and Pterocarpus santalinoides." GSC Biological and Pharmaceutical Sciences 25, no. 1 (2023): 086–94. http://dx.doi.org/10.30574/gscbps.2023.25.1.0384.

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Plants are believed to be an essential source of new chemical substances with potential therapeutic effect. The aim of this study is to test for the GCMS analysis and FT-IR analysis of the extract of Medicago sativa , Gongronema latifolium and Pterocarpus santalinoides. FTIR spectroscopy of all selected extracts confirms the presence of alkanes, alkynes, carboxylic acids, aldehydes and nitriles functional groups while the major bioactive compounds detected in the extracts were protchaechenic acid, hydroxyl benzoic acid , b-Phenyl caffate and kaempherol.

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Ujong, Gabriel Otu, Justin Atiang Beshel, Etah Nkanu, Oden Patrick Ubana, and Ofem Effiong Ofem. "Ethanolic extract of Gongronema latifolium improves learning and memory in Swiss albino Mice." Journal of Drug Delivery and Therapeutics 12, no. 1 (2022): 45–50. http://dx.doi.org/10.22270/jddt.v12i1.5276.

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Learning and memory are vital attributes of human intelligence. These processes underlie the very nature of our self-awareness, planning and execution of task. The number of people living with dementia worldwide is currently estimated at 35.6 million. About 80% of the world’s population depend on herbal remedies to curb mental disorders. This study aimed to investigate the effects of administration of ethanolic leaves extract of Gongronema latifolium (GL) on learning and memory in mice. Thirty (30) adult male Swiss white mice were assigned into three groups of ten mice each. Group I served as

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Obijuru, N.T., R.N Nwaoguikpe, A.C. Ene, and C.U. Igwe. "Characterization and biological activity of some anti-diabetic plants: Medicago sativa Gongronema latifolium and Pterocarpus santalinoides." GSC Biological and Pharmaceutical Sciences, no. 1 (October 30, 2023): 086–94. https://doi.org/10.5281/zenodo.10575005.

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Plants are believed to be an essential source of new chemical substances with potential therapeutic effect. The aim of this study is to test for the GCMS analysis and FT-IR analysis of the extract of <em>Medicago sativa , Gongronema latifolium</em> and <em>Pterocarpus santalinoides.</em> FTIR spectroscopy of all selected extracts confirms the presence of alkanes, alkynes, carboxylic acids, aldehydes and nitriles functional groups while the major bioactive compounds detected in the extracts were protchaechenic acid, hydroxyl benzoic acid , b-Phenyl caffate and kaempherol.

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Chidozie, Vivian N., Nita Mgbemena, and Emmanuel Onah Isegbe. "Comparative Effects of Ethanolic Leaf Extracts of Gongronema latifolium Benth and Bryophyllum pinnatum (Lam.) Oken in The Management of Diabetes Mellitus in Albino Rats." Afghanistan Journal of Basic Medical Science 1, no. 1 (2023): 1–10. http://dx.doi.org/10.62134/ajbms/v1.i1.khatamuni.1.

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Introduction: Diabetes is a multi-factorial metabolic disorder characterized by hyperglycemia, which is the primary factor in preventing glucose from achieving its desired levels in patients with the condition. Hyperglycemia results from a lack of insulin secretion, inadequate insulin action or both. Materials and Methods: The comparative effects of ethanolic leaf extracts of The comparative effects of ethanolic leaf extracts of Gongronema latifolium (G. latifolium) and Bryophyllum pinnatum (B. pinnatum) on some biochemical parameters in diabetic induced albino rats were investigated. Two diff

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Peter, Alice J., Innocent A. Edagha, Aniekan I. Peter, et al. "Ameliorative Potential of Azadirachta indica and Gongronema latifolium on Plasmodium-induced Gonadotoxicity in Swiss Mice." International Journal of Anatomy and Research 11, no. 4 (2023): 8761–77. http://dx.doi.org/10.16965/ijar.2023.217.

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Background: Polyherbal decoctions are frequently utilized by some Africans for anti-malaria treatment because they are readily accessible, and assumed low toxicity despite possible gonadotoxicities. We investigated ameliorative potential of anti-plasmodial plants Azadirachta indica (AI) and Gongronema latifolium (GL) on Plasmodium-induced gonadotoxities. Materials and methods: Adult male Swiss mice (n = 50) were allotted into 10 groups of (n = 5) animals. All groups were parasitized with 1 × 106P. berghei inoculum for three days except for groups 1 and 10; (normal control [NC]) and (non-parasi

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Obijuru N.T, Igwe, C.U, Ene A. C, and Nwaoguikpe R. N. "Effect of ethanolic leaf extracts of Medicago sativa, Gongronema latifolium and Pterocarpus sanalinoides on the liver integrity of alloxan-induced diabetic albino rats." GSC Biological and Pharmaceutical Sciences 25, no. 1 (2023): 178–85. http://dx.doi.org/10.30574/gscbps.2023.25.1.0427.

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The study investigated the effects of ethanolic leaf extracts of Medicago sativa (MS), Pterocarpus santalinoides (PS) and Gongronema latifolium (GL) on the liver function profile and organ histology integrity of alloxan-induced diabetic albino rats. Sixty male rats were divided into 10 groups, made up of 1 group each of normal, diabetic, and positive controls, 3 treatment groups each of the single and pairwise extract combinations, and 1 group of the ternary extracts combination. Hyperglycaemia was induced in the treatment groups by a single intraperitoneal injection of alloxan at 150 mg/kg bo

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Gabriel, O. Ujong. "Ethanolic Leaf Extract of Gongronema Latifolium Prevents Depletion of Nitric Oxide and Anti-Oxidants Levels in Streptozotocin Induced Diabetic Rats." Der Pharma Chemica 14, no. 3 (2022): 6. https://doi.org/10.4172/0975-413X.14.3.22-27.

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Lipid peroxidation is a major disorder that disrupts cellular integrity, resulting in many pathological conditions. This work was designed to evaluate the effect of ethanolic leaf extract of Gongronema latifolium (GL) on nitric oxide, anti-oxidants (SOD, total anti-oxidant capacity) and lipid peroxidation product (MDA) in Streptozotocin-induced diabetic rats. 40 Wistar rats of both sexes (150g-200g) were divided into 5 groups (n=8). Group 1 (control) received 1mL normal saline orally. Group 2 (GL) received 200 mg/kg b.wt. Of GL orally. Group 3 (DM) received 65mg/kg b.wt. of streptozotocin (STZ

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Chidi, Edenta. "ANTI-HYPERGLYCEMIC AND ANTI-OXIDANT ACTIVITIES OF METHANOL EXTRACT OF GONGRONEMA LATIFOLIUM." Universal Journal of Pharmaceutical Research 2, no. 2 (2017): 35–38. http://dx.doi.org/10.22270/ujpr.v2i2.r4.

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Etesin, Usoro, Ibanga Isaac, Edidiong Ikpe, Gershom Ufikairo, and Asuquo Unyime Joseph. "Screening for Minerals and Anti-minerals Composition of Gongronema latifolium (Utasi) Leaf." Asian Journal of Chemical Sciences 4, no. 4 (2018): 1–8. http://dx.doi.org/10.9734/ajocs/2018/43389.

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Morebise, Olugbenga. "A Review on Gongronema latifolium, an Extremely Useful Plant with Great Prospects." European Journal of Medicinal Plants 10, no. 1 (2015): 1–9. http://dx.doi.org/10.9734/ejmp/2015/19713.

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Ezekwe,, C. I., S. C. Ezea,, and O. F. C. Nwodo,. "Evaluation of hypoglycaemic activity of ethanol extract of Gongronema latifolium (Asclepiadaceae) leaves." African Journal of Biotechnology 13, no. 27 (2014): 2750–54. http://dx.doi.org/10.5897/ajb2013.13146.

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Ikwuemesi, J. C., O. E. Irozuru, and I. J. Okwu. "Growth performances, nutrient utilization and haematology of Clarias gariepinus juveniles fed varying concentrations of Gongronema latifolium leaf extracts." Journal of Aquatic Sciences 34, no. 2 (2020): 97–105. http://dx.doi.org/10.4314/jas.v34i2.12.

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There had been growing interest in the use of extracts from different plants species to boost fish production. In this study Gongronema latifolium leaf extract was supplemented in a commercial diet of Clarias gariepinus juveniles at varying concentrations of 0.5g (T2), 1.0g (T3) and 1.5g (T4) per kg of feed while the control (T1) had no leaf extract. They were fed for 8weeks while growth performance and haematological data were collected and analysed. Proximate composition of the fish flesh was carried out after the feeding trials. The initial mean weight ranged between 9.0±0.5 to 9.0±0.7g, th

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