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Journal articles on the topic 'Gonococcal Urethritis'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Edwards, Jennifer L., and Michael A. Apicella. "The Molecular Mechanisms Used by Neisseria gonorrhoeae To Initiate Infection Differ between Men and Women." Clinical Microbiology Reviews 17, no. 4 (2004): 965–81. http://dx.doi.org/10.1128/cmr.17.4.965-981.2004.

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SUMMARY The molecular mechanisms used by the gonococcus to initiate infection exhibit gender specificity. The clinical presentations of disease are also strikingly different upon comparison of gonococcal urethritis to gonococcal cervicitis. An intimate association occurs between the gonococcus and the urethral epithelium and is mediated by the asialoglycoprotein receptor. Gonococcal interaction with the urethral epithelia cell triggers cytokine release, which promotes neutrophil influx and an inflammatory response. Similarly, gonococcal infection of the upper female genital tract also results

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2

Uno, M., T. Deguchi, H. Komeda, et al. "Prevalence of Mycoplasma genitalium in men with gonococcal urethritis." International Journal of STD & AIDS 7, no. 6 (1996): 443–44. http://dx.doi.org/10.1258/0956462961918284.

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A significant association of Mycoplasma genitalium with non-gonococcal urethritis has been reported, but the prevalence of this mycoplasma in men with gonococcal urethritis has not been so well studied. In this study, we examined urethral swab specimens from 45 Japanese male patients with gonococcal urethritis for the presence of M. genitalium by using a polymerase chain reaction-based assay. We also sought Chlamydia trachomatis by an enzyme immunoassay Chlamydiazyme . Of the 45 specimens, 2 4.4 were positive for the mycoplasma and 12 26.7 were positive for C. trachomatis. The findings suggest

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3

Perkins, Matthew J., and Catherine F. Decker. "Non-gonococcal urethritis." Disease-a-Month 62, no. 8 (2016): 274–79. http://dx.doi.org/10.1016/j.disamonth.2016.03.011.

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4

O'Mahony, C. "Adenoviral non-gonococcal urethritis." International Journal of STD & AIDS 17, no. 3 (2006): 203–4. http://dx.doi.org/10.1258/095646206775809312.

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Adenoviruses infect mucous membranes, including – on rare occasions – the urethra. Adenoviruses should therefore be considered as yet another cause of chlamydia-negative non-gonococcal urethritis. The following case illustrates the dilemma posed in a patient with conjunctivitis and urethritis.

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5

Hilton, Jackie, Sunita Azariah, and Murray Reid. "A case-control study of men with non-gonococcal urethritis at Auckland Sexual Health Service: rates of detection of Mycoplasma genitalium." Sexual Health 7, no. 1 (2010): 77. http://dx.doi.org/10.1071/sh09092.

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Background: Previous studies have identified Mycoplasma genitalium as a cause of urethritis in men. As there is no New Zealand data, a case-control study was conducted to determine whether this organism is a significant cause of urethritis in men presenting to Auckland Sexual Health Service. Methods: Enrolment for the study commenced in March 2006 and finished in February 2008. Inclusion criteria for cases of non-gonococcal urethritis were onset of urethritis symptoms within one month confirmed by urethral Gram staining showing ≥10 polymorphonuclear leucocytes per high-powered field. Controls

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6

Wang, Mei-fang, Li Wang, and Lin-feng Li. "Gonococcal conjunctivitis after incomplete treatment of gonococcal urethritis." Infection and Drug Resistance Volume 12 (May 2019): 1381–84. http://dx.doi.org/10.2147/idr.s199163.

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7

Manavi, K., A. McMillan, and H. Young. "Non-chlamydial non-gonococcal urethritis or undiagnosed chlamydial urethritis?" International Journal of STD & AIDS 17, no. 5 (2006): 296–98. http://dx.doi.org/10.1258/095646206776790178.

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The aim of this study is to investigate the prevalence of sexually transmitted infections (STI) in the partners of men with non-chlamydial, non-gonococcal urethritis (NCNGU). Observational study of the sexual partners of men with NCNGU diagnosed in the Department of Genitourinary Medicine, Edinburgh between 1 June 2002 and 31 December 2003. The diagnosis of chlamydial infection was based on ligase chain reaction (LCx) between June 2002 and March 2003, and on polymerase chain reaction (PCR) thereafter. Gonococcal infection was diagnosed with culture method. Sexual partners of 99 (25%) of the 40

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8

Kim, D. G. Kim, M. A. Gomberg Gomberg, A. E. Gushchin Gushchin, and A. V. Zaycev Zaycev. "Non-gonococcal urethritis in men." Urologiia 4_2019 (September 9, 2019): 122–28. http://dx.doi.org/10.18565/urology.2019.4.122-128.

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9

Hay, P. E., and S. Ghaem-Maghami. "Chlamydia and non-gonococcal urethritis." Current Opinion in Infectious Diseases 10, no. 1 (1997): 44–49. http://dx.doi.org/10.1097/00001432-199702000-00011.

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10

Shahmanesh, M. "Problems with Non-Gonococcal Urethritis." International Journal of STD & AIDS 5, no. 6 (1994): 390–99. http://dx.doi.org/10.1177/095646249400500603.

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11

Deguchi, T., H. Komeda, M. Yasuda, et al. "Mycoplasma Genitaliumin Non-Gonococcal Urethritis." International Journal of STD & AIDS 6, no. 2 (1995): 144–45. http://dx.doi.org/10.1177/095646249500600219.

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12

Horner, P. J., and D. Taylor-Robinson. "Mycoplasmas and non-gonococcal urethritis." Sexually Transmitted Infections 70, no. 1 (1994): 73–74. http://dx.doi.org/10.1136/sti.70.1.73-c.

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13

Brook, M. G., and C. Bell. "Screening for non-gonococcal urethritis." International Journal of STD & AIDS 15, no. 1 (2004): 69. http://dx.doi.org/10.1258/095646204322637362.

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14

Horner, PatrickJ, RichardJ Coker, MichaelM Mcbride, and SiobhanM Murphy. "Changing gonococcal urethritis in men." Lancet 341, no. 8847 (1993): 761. http://dx.doi.org/10.1016/0140-6736(93)90536-p.

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15

Taylor-Robinson, D., S. Mitchell, and R. N. Thin. "Aetiology of Non-Gonococcal Urethritis." International Journal of STD & AIDS 2, no. 3 (1991): 216–17. http://dx.doi.org/10.1177/095646249100200319.

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16

Monteiro, E., G. R. Kinghorn, and R. C. Spencer. "Quinolones in non-gonococcal urethritis." Sexually Transmitted Infections 62, no. 6 (1986): 403–4. http://dx.doi.org/10.1136/sti.62.6.403.

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17

Azariah, S., and M. Reid. "Adenovirus and non-gonococcal urethritis." International Journal of STD & AIDS 11, no. 8 (2000): 548–50. http://dx.doi.org/10.1258/0956462001916308.

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18

Bell, C., and G. Brook. "Screening for non-gonococcal urethritis." International Journal of STD & AIDS 14, no. 5 (2003): 360. http://dx.doi.org/10.1258/095646203321605594.

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19

Horner, P. J., and D. Taylor-Robinson. "Screening for non-gonococcal urethritis." International Journal of STD & AIDS 14, no. 10 (2003): 715. http://dx.doi.org/10.1258/095646203322407890.

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20

Pollack, Alisa, and Rick Varma. "Adenovirus-associated paraphimosis." International Journal of STD & AIDS 30, no. 8 (2019): 825–27. http://dx.doi.org/10.1177/0956462419842448.

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We present the first reported case of paraphimosis associated with concurrent adenoviral urethritis and conjunctivitis in a heterosexual man. This case reinforces the need to consider adenovirus in the differential diagnosis of non-gonococcal urethritis and describes a potentially serious complication.

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21

Burka, O. A., and N. F. Ligirda. "Mycoplasma genitalia – a mysterious destroyer." HEALTH OF WOMAN, no. 6(132) (July 30, 2018): 10–14. http://dx.doi.org/10.15574/hw.2018.132.10.

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Mycoplasma genitalium is a common cause of cervicitis and non-gonococcal urethritis. Today, this causative agent is already associated with inflammatory diseases of the pelvic organs and sexually acquired reactive arthritis. The only diagnostic method is a nucleic acid amplification (NAAT) test that detects specific DNA (PCR) or M. genitalium RNA. Several treatment regimens are proposed, depending on the uncomplicated or complicated course of M. genitalium infection and the determination of macrolide resistance. Key words: Mycoplasma genitalium, sexually transmitted infections, inflammatory di

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22

Woolley, P. D. "Anaerobic bacteria and non-gonococcal urethritis." International Journal of STD & AIDS 11, no. 6 (2000): 347–48. http://dx.doi.org/10.1258/0956462001915976.

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Anaerobic bacteria are frequent inhabitants of the urethra of both normal men and men with non-gonococcal urethritis. All microbiologically-based studies have shown them not to have a role in the aetiology of the condition. However, Bacteroides ureolyticus continues to be an enigma having been isolated more commonly from men with urethritis in some studies, not confirmed by others, as well as in treatment-based studies in which the organism has been implicated by some authors. Few studies related to anaerobic organisms in the male genital tract have been conducted during the last decade.

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23

Genders, R. E., D. Spitaels, C. L. Jansen, Th W. van den Akker, and K. D. Quint. "A misleading urethral smear with polymorphonuclear leucocytes and intracellular diplococci; case report of urethritis caused by Neisseria meningitidis." Journal of Medical Microbiology 62, no. 12 (2013): 1905–6. http://dx.doi.org/10.1099/jmm.0.059378-0.

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The primary pathogens found in men with urethritis are Chlamydia trachomatis and Neisseria gonorrhoeae. Rapid diagnosis of N. gonorrhoeae infection can be made based on a Gram- or methylene blue-stained urethral smear. We describe a case of a man with purulent penile discharge, in which microscopic examination led to the presumptive diagnosis of gonorrhoea. A nucleic acid amplification test was negative for N. gonorrhoeae but positive for C. trachomatis. Culture showed Gram-negative diplococci which were identified as Neisseria meningitidis. N. meningitidis can be sporadically pathogenic in th

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24

Komolafe, A. J., P. A. Cornford, M. V. P. Fordham, and D. J. Timmins. "Periurethral abscess complicating male gonococcal urethritis treated by surgical incision and drainage." International Journal of STD & AIDS 13, no. 12 (2002): 857–58. http://dx.doi.org/10.1258/095646202321020189.

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25

Björnelius, Eva, Peter Lidbrink, and Jørgen Skov Jensen. "Mycoplasma Genitalium in Non-Gonococcal Urethritis — A Study in Swedish Male STD Patients." International Journal of STD & AIDS 11, no. 5 (2000): 292–96. http://dx.doi.org/10.1177/095646240001100504.

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Urethral swab specimens obtained from 101 men attending an STD clinic were examined for the presence of Mycoplasma genitalium by polymerase chain reaction (PCR) amplification. Fifty patients had non-gonococcal urethritis (NGU), and 51 patients were included as controls without urethritis. M. genitalium DNA was detected in 13 (26%) of the urethritis patients and in 5 (10%) of the control patients ( P=0.06). No patient positive for M. genitalium had a simultaneous chlamydial infection. Thus, in the 36 patients with non-chlamydial NGU, the prevalence of M. genitalium infection was 36% ( P=0.007 c

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26

Nolan, Ryan P., Abraham J. Mathew, Ibrahim O. Sayed-Ahmed, and Zaina Al-Mohtaseb. "Corneal thinning and deteriorating vision in a patient with urethritis." Indian Journal of Ophthalmology - Case Reports 4, no. 1 (2024): 5–7. http://dx.doi.org/10.4103/ijo.ijo_1262_23.

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Gonococcal keratoconjunctivitis is a rare infection most often occurring in the setting of preexisting urethritis. Prompt complete eradication of the infection is vital for the prevention of corneal perforation. The authors present a case of gonococcal keratoconjunctivitis in the setting of untreated urethritis in a 34-year-old male. Given his degree of marginal corneal thinning, the patient was admitted for treatment and required an amniotic membrane graft. The patient returned to baseline following treatment. The authors highlight the role that irrigating the corneal gutter played in the com

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27

Dwari, Binayak Chandra, Mamata Bhatt, Minati Mishra, Nalinikanta Tripathy, and P. K. Sathpathy. "Male urethritis with or without discharge: a clinico aetiological study in Hi-tech Medical College and Hospital Bhubaneswar, Odisha." International Journal of Research in Dermatology 4, no. 4 (2018): 484. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20183377.

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<p class="abstract"><strong>Background:</strong> Urethritis or inflammation of the urethra is a multifactorial condition. Urethritis is called gonococcal urethritis (GU) when Neisseria gonorrhoeae is detected in urethral smear of the patient and nongonococcal urethritis (NGU) when this organism cannot be visualized.</p><p class="abstract"><strong>Methods:</strong> Urethritis cases were identified from the dermatology OPD record. A retrospective analysis of data of patients diagnosed as GU and NGU for a period of 5 years (from August 2012-July 2017) was

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28

Horner, Paddy. "Chlamydia trachomatis and non-gonococcal urethritis." Medicine 33, no. 10 (2005): 40–42. http://dx.doi.org/10.1383/medc.2005.33.10.40.

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29

Carter, Naomi, and Paddy Horner. "Treatment regimens in non-gonococcal urethritis." Sexually Transmitted Infections 91, no. 4 (2015): 244. http://dx.doi.org/10.1136/sextrans-2014-051837.

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30

Oriel, J. D. "The history of non-gonococcal urethritis." Sexually Transmitted Infections 72, no. 5 (1996): 374–79. http://dx.doi.org/10.1136/sti.72.5.374.

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31

Harryman, Lindsey, and Paddy Horner. "Chlamydia trachomatis and non-gonococcal urethritis." Medicine 38, no. 5 (2010): 249–54. http://dx.doi.org/10.1016/j.mpmed.2010.01.003.

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32

Harryman, Lindsey, Karla Blee, and Paddy Horner. "Chlamydia trachomatis and non-gonococcal urethritis." Medicine 42, no. 6 (2014): 327–32. http://dx.doi.org/10.1016/j.mpmed.2014.03.001.

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33

Hooton, ThomasM, MarilynC Roberts, and GeorgeE Kenny. "Mycoplasma genitalium and non-gonococcal urethritis." Lancet 343, no. 8889 (1994): 69. http://dx.doi.org/10.1016/s0140-6736(94)90810-9.

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34

Horner, P. J., and D. Taylor-Robinson. "Mycoplasma genitalium and non-gonococcal urethritis." Lancet 343, no. 8900 (1994): 790–91. http://dx.doi.org/10.1016/s0140-6736(94)91865-1.

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35

Masterton, R. G., and N. A. Harrison. "Single dose piperacillin in gonococcal urethritis." Sexually Transmitted Infections 64, no. 2 (1988): 134–35. http://dx.doi.org/10.1136/sti.64.2.134-a.

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36

Barbee, Lindley A., Olusegun O. Soge, Negusse Ocbamichael, Angela LeClair, and Matthew R. Golden. "Single-Arm Open-Label Clinical Trial of Two Grams of Aztreonam for the Treatment of Neisseria gonorrhoeae." Antimicrobial Agents and Chemotherapy 65, no. 1 (2020): e01739-20. http://dx.doi.org/10.1128/aac.01739-20.

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ABSTRACTThe threat of ceftriaxone-resistant Neisseria gonorrhoeae necessitates new gonorrhea treatment regimens. Repurposing older antibiotics not routinely used for N. gonorrhoeae may expeditiously identify new therapies. Ideally, all recommended therapies should eradicate gonorrhea at the pharynx. Between April and September 2019, we enrolled men in an open-label, one-arm clinical trial of single-dose intramuscular aztreonam (2 g). Enrollment criterion included (i) nucleic acid amplification test (NAAT)-positive pharyngeal gonorrhea for ≤14 days or (ii) Gram stain-positive gonococcal urethri

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37

Fan, Wenge, Qingsong Zhang, Mei Wei, et al. "Gonococcal Infection of the Glans Skin, a Rare Local Complication of Gonorrhea: A Clinical Study of 13 Cases." American Journal of Men's Health 17, no. 1 (2023): 155798832311521. http://dx.doi.org/10.1177/15579883231152111.

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The study aimed to understand the incidence, site, skin lesion manifestations, and treatment of gonococcal infection of the glans skin. We enrolled men with gonococcal infection of the glans skin and men with gonococcal urethritis from January 2014 to February 2020. Demographic data, site of onset, and skin lesion manifestations were recorded for all patients. Ceftriaxone (1 g) was injected intramuscularly once daily for 5 days in patients with lesions comprising abscesses or nodules. A single dose of ceftriaxone (1 g) was injected intramuscularly in patients with pustules. Incision and draina

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38

Maharaj, Rasha, and Girish M. Mody. "The rarity of gonococcal arthritis in association with HIV infection." Journal of Infection in Developing Countries 8, no. 09 (2014): 1222–27. http://dx.doi.org/10.3855/jidc.4450.

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Gonococcal urethritis is common with HIV, but gonococcal arthritis is rare. We report two HIV-positive patients with gonococcal arthritis and review previously published reports. A 27-year-old HIV-positive female presented with a pustular skin rash and acute oligoarthritis. Neisseria gonorrhoeae was cultured from the right elbow aspirate. The second patient, a 24-year-old HIV-positive female on zidovudine for one month, presented at 28 weeks gestation with acute oligoarthritis and peroneal tenosynovitis. Neisseria gonorrhoeae was cultured from the throat swab. Both patients responded to ceftri

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39

SCHMIDT, KATHERINE A., HERMAN SCHNEIDER, JILL A. LINDSTROM, et al. "Experimental Gonococcal Urethritis and Reinfection with Homologous Gonococci in Male Volunteers." Sexually Transmitted Diseases 28, no. 10 (2001): 555–64. http://dx.doi.org/10.1097/00007435-200110000-00001.

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40

Taylor-Robinson, D., A. Renton, J. S. Jensen, et al. "Association ofMycoplasma genitaliumwith acute non-gonococcal urethritis in Russian men: a comparison with gonococcal and chlamydial urethritis." International Journal of STD & AIDS 20, no. 4 (2009): 234–37. http://dx.doi.org/10.1258/ijsa.2008.008298.

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41

Deguchi, T., M. Yasuda, S. Maeda, et al. "P1333 Coinfection of genital mycoplasmas among men with gonococcal urethritis and their roles in post-gonococcal urethritis." International Journal of Antimicrobial Agents 29 (March 2007): S369. http://dx.doi.org/10.1016/s0924-8579(07)71173-1.

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42

Salari, M. H., and A. Karimi. "Prevalence of Ureaplasma urealyticum and Mycoplasma genitalium in men with non-gonococcal urethritis." Eastern Mediterranean Health Journal 9, no. 3 (2021): 291–95. http://dx.doi.org/10.26719/2003.9.3.291.

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The study in Teheran, Islamic Republic of Iran, investigated the prevalence of Ureaplasma urealyticum and Mycoplasma species in men with non-gonococcal urethritis. Urethral swab samples were collected from 125 cases and 125 healthy men as a control group. The samples were then investigated by culture methods. The rates of detected bacteria in case and control groups were 19.2% and 7.2% for U. urealyticum, 7.2% and 0.8% for M. genitalium, and 2.4% and 1.6% for M. hominis respectively. Statistical analysis showed a significant difference between case and control groups in the prevalence of U. ur

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43

Deguchi, Takashi, Hisao Komeda, Emiko Kanematsu, et al. "DIAGNOSIS OF GONOCOCCAL URETHRITIS AND CHLAMYDIAL URETHRITIS BY POLYMERASE CHAIN REACTION." Japanese Journal of Urology 83, no. 12 (1992): 2070–77. http://dx.doi.org/10.5980/jpnjurol1989.83.2070.

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44

Woolley, P. D., G. R. Kinghorn, M. D. Talbot, and B. I. Duerden. "Efficacy of Combined Metronidazole and Triple Tetracycline Therapy in the Treatment of Non-Gonococcal Urethritis." International Journal of STD & AIDS 1, no. 1 (1990): 35–37. http://dx.doi.org/10.1177/095646249000100109.

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In a double-blind placebo-controlled trial using triple tetracycline (Deteclo, Lederle) 300 mg twice daily for two weeks in conjunction with metronidazole (Flagyl, May & Baker) 400 mg or matching placebo twice daily for seven days, it was shown that the addition of anti-anaerobic therapy did not significantly affect the number of cases of persistent urethritis or the relapse rate of patients with non-gonococcal urethritis (NGU).

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45

Taylor-Robinson, D., J. S. Jensen, G. Fehler, F. Radebe, and R. C. Ballard. "Observations on the microbiology of urethritis in black South African men." International Journal of STD & AIDS 13, no. 5 (2002): 323–25. http://dx.doi.org/10.1258/0956462021925144.

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The occurrence of Neisseria gonorrhoeae, Chlamydia trachomatis and Mycoplasma genitalium was determined by molecular techniques in urine specimens from 182 black South African men who had symptoms and/or overt signs of urethritis. Eighty-six (47.3%) of these men were infected with N. gonorrhoeae. There were 185 men without overt evidence of urethritis, 16 (8.6%) of whom were also infected with N. gonorrhoeae. Of the 96 men who had non-gonococcal urethritis, 14 (14.6%) were infected with C. trachomatis, 16 (16.7%) with M. genitalium and only one with both microorganisms. In comparison, 15 (8.9%

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46

Singal, P. Sharma, A. "Methicillin-resistant Staphylococcus aureus Non-gonococcal Urethritis." Acta Dermato-Venereologica 79, no. 5 (1999): 415. http://dx.doi.org/10.1080/000155599750010599.

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47

Shahmanesh, M., P. G. Pandit, and R. Round. "Urethral lymphocyte isolation in non-gonococcal urethritis." Sexually Transmitted Infections 72, no. 5 (1996): 362–64. http://dx.doi.org/10.1136/sti.72.5.362.

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48

Taylor-Robinson, D., C. B. Gilroy, B. J. Thomas, and P. E. Hay. "Mycoplasma genitalium in chronic non-gonococcal urethritis." International Journal of STD & AIDS 15, no. 1 (2004): 21–25. http://dx.doi.org/10.1258/095646204322637209.

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49

O'Mahony, Colm. "Asymptomatic Chlamydia trachomatis-negative non-gonococcal urethritis." International Journal of STD & AIDS 16, no. 4 (2005): 330. http://dx.doi.org/10.1258/0956462053654285.

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50

Deguchi, Takashi. "Proposed treatment strategies for non-gonococcal urethritis." Lancet Infectious Diseases 17, no. 11 (2017): 1121–22. http://dx.doi.org/10.1016/s1473-3099(17)30571-6.

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