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Dissertations / Theses on the topic 'Gonorrhoea'

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1

Dunn, Sarah I. "Characterisation of Cytochrome c peroxidase: A vaccine candidate for Neisseria gonorrhoeae." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/403639.

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Neisseria gonorrhoeae is an obligate human pathogen and the causative agent of gonorrhoea, a sexually transmitted infection. Over 100 million cases of gonorrhoea are reported globally each year. Antibiotics have been widely used to treat gonorrhoea. However, with the recent emergence of multi-drug resistance strains, gonorrhoea has been recognised as a major public health challenge and a vaccine for N. gonorrhoeae is urgently required. Previously, vaccine development has been challenging due to the bacteria’s ability to avoid and modulate the hosts immune response. Conserved surface components
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2

Berglund, Torsten. "Recent trends in the epidemiology of gonorrhoea in Sweden : the role of importation and core groups /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-692-1/.

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3

Chen, I.-Cheng Mark. "Gonorrhoea and resistant gonorrhoea in England and Wales : epidemiological modelling for insight and control." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590549.

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4

Ross, Jonathan Denys Crawford. "The epidemiology of gonococcal serovars in Edinburgh 1990-1993." Thesis, University of Aberdeen, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282707.

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With the advent of gonococcal stereotyping many areas have reported wide differences in their prevalence of different strains of infection. This study was designed in an attempt to correlate a variety of clinical markers of infection and characteristics of the organism with the observed serovar pattern. All patients with a laboratory diagnosis of gonorrhoea in Edinburgh between January 1990 and December 1993, most of whom attended the Genitourinary Medicine clinic, were included in the study. For comparison a more limited analysis was also performed on patients attending Genitourinary Medicine
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5

Cole, Michelle Jayne. "Extended-spectrum β-lactamases and Neisseria gonorrhoeae : pre-empting a mechanism that could abolish cephalosporins for the treatment of gonorrhoea". Thesis, University of Portsmouth, 2015. https://researchportal.port.ac.uk/portal/en/theses/extendedspectrum-lactamases-and-neisseria-gonorrhoeae(a32240b8-c498-4dc3-b276-6491bbc32bf2).html.

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Neisseria gonorrhoeae is a public health concern due to increasing numbers of cases of gonorrhoea and the ability of the organism to develop antimicrobial resistance. N. gonorrhoeae can harbour β-lactamase plasmids that encode TEM-1 penicillinase, but do not produce extended spectrum β-lactamases (ESBLs). ESBLs are active against the last remaining option for gonorrhoea monotherapy, ceftriaxone. The aim of this research was to establish what resistance mechanisms in N. gonorrhoeae could abolish the effectiveness of ceftriaxone for the treatment of gonorrhoea. Investigations into the genetic di
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6

Turner, Katherine Mary Elizabeth. "Mathematical models of gonorrhoea and chlamydia : biology, behaviour and interactions." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/1303.

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Gonorrhoea and chlamydia are curable, bacterial, sexually transmitted infections (STIs) of humans, with important long term consequences for health. Their epidemiology and biology are reviewed in chapter one. The way the biology of the organisms and the behaviour of human hosts interact to influence the patterns of infection and the potential impact of interventions is the subject of the main body of the thesis. Mathematical models are presented, together with empirical data, to gain a better understanding of the epidemiology of gonorrhoea and chlamydia. New approaches are applied, using more
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7

Ussher, Greg. "'The medical gaze and the watchful eye' : the treatment, prevention and epidemiology of venereal diseases in New South Wales c.1901 - 1925." University of Sydney, 2007. http://hdl.handle.net/2123/3565.

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Doctor of Philosophy(PhD)<br>From Federation in 1901 through the first three decades of the twentieth century there was a perceptible shift in modes of rule in New South Wales (NSW) related to the management of venereal diseases. At the beginning of the twentieth century a medicopenal approach was central. By 1925, persuasion and ‘responsibilisation’ were becoming important modes, and young people rather than ‘case-hardened prostitutes' were assessed as being a ‘venereal’ risk. Framing this period were three important legislative developments which informed, and were informed by, these shifts:
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8

Renton, Adrian Mark. "The epidemiology of gonorrhoea in adults and its sexual behavioural determinants." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283441.

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9

Rytkönen, Anne. "Molecular studies of Neisseria - host cell interactions /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-018-4/.

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10

Hiltunen-Back, Eija. "Epidemiology of syphilis, gonorrhoea and chlamydia trachomatis infection in Finland in the 1990s." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/hiltunen-back/.

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11

McMillan, Noto Jennifer. "Analysis of the mechanism of transferrin-iron acquisition by Neisseria gonorrhoeae." Online version unavailable until 9/16/2013, 2008. http://hdl.handle.net/10156/2294.

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12

Templeton, David James Public Health &amp Community Medicine Faculty of Medicine UNSW. "The role of circumcision and pharyngeal STIs in HIV and STI transmission among homosexual men." Publisher:University of New South Wales. Public Health & Community Medicine, 2008. http://handle.unsw.edu.au/1959.4/43239.

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This thesis presents data on two separate areas relevant to the prevention of HIV and sexually transmitted infection (STI) transmission in homosexual men. These data arise from the community-based Health in Men (HIM) cohort of HIV-negative homosexual men in Sydney. First, the association of circumcision status with HIV and STIs was examined. Older age, ethnicity and country of birth were demographic factors independently associated with circumcision status. Self-report was a valid measure of circumcision status in this population. Overall, being circumcised was associated with a non-significan
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13

Schweikardt, Christoph. "General Practice Research Networks in Belgium: Development, Context and their Contribution to the Monitoring of Sexually Transmitted Infections." Doctoral thesis, Universite Libre de Bruxelles, 2019. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/287427.

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This thesis is devoted to general practice (GP) networks in Belgium, their development and their activities within the Belgian health system context. These networks are specific research tools for the repeated or continuous collection and analysis of data related to diseases and other health events observed in general practice, including interventions of general practitioners. The thesis focuses on three not-for-profit general practice research networks which are operational today: (1) the national Network of Sentinel General Practices (SGP), coordinated by the Federal research institute Scien
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14

Pickel, Donnie. "Investigating Complement Regulator Involvement in Innate Immune Evasion by Neisseria gonorrhoeae." Ohio University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1628181973757983.

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15

Bergman, Peter. "Antimicrobial peptides and pathogenic Neisseria : experimental studies in mouse, man and rat /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-428-7/.

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16

Al-Hattawi, Kaltham Mohammed Salem. "Gonorrhoeae in Dubai - UAE." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266202.

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17

Perrollet, Hervé. "Lectine-adhésine de Neisseria gonorrhoeae." Lyon 1, 1987. http://www.theses.fr/1987LYO1T123.

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18

Perrollet, Hervé. "Lectine-adhésine de Neisseria gonorrhoeae." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb376088235.

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19

Cousin, Sydney Louis. "Macrolide resistance in Neisseria gonorrhoeae /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/5078.

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20

Copley, C. G. "Studies on typing of Neisseria gonorrhoeae." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356312.

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21

Overton, Timothy William. "The FNR protein of Neisseria gonorrhoeae." Thesis, University of Birmingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288548.

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22

Fong, Yuet-ping. "Seasonal variation in cause-specific sexually transmitted disease morbidity in Hong Kong (1998-2001) : are there any long holiday effects on the morbidity due to Neisseria gonorrhoeae? /." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25100981.

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23

Perry, Elizabeth Holly. "Association of ABO, Lewis and Secretor phenotypes and genotypes with Neisseria gonorrhoeae thesis submitted in (partial) fulfilment of the Master of Applied Science, Auckland University of Technology, November 2003." Full thesis. Abstract, 2003. http://puka2.aut.ac.nz/ait/theses/PerryE.pdf.

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24

ROCK, JOHN PATRICK. "MOLECULAR BIOLOGY OF GONOCOCCAL DEATH FOLLOWING EXPOSURE TO THE GRANULE EXTRACTS OF HUMAN NEUTROPHILS (NEISSERIA GONORRHOEAE, PEPTIDOGLYCAN, MEMBRANE DAMAGE)." Diss., The University of Arizona, 1986. http://hdl.handle.net/10150/183844.

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Gonococci that have been phagocytized by human neutrophils are killed very effectively. While much research has focused on defining the microbicidal mechanisms of the neutrophil arsenal, substantially less is known regarding why phagocytized bacteria die. Gonococci were examined, at the molecular level, following exposure to human neutrophil granule extracts (GE) in an effort to discover the "lethal lesion", that injury to the bacterial cell which results in its death. The cytoplasm-based metabolism of GE-treated gonococci continues to function normally for at least 30 minutes, although these
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25

Zhao, Ken Kun. "Treatments of Chlamydia Trachomatis and Neisseria Gonorrhoeae." Digital Archive @ GSU, 2008. http://digitalarchive.gsu.edu/math_theses/49.

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Chlamydia Trachomatis and Neisseria Gonorrhoeae rank as the two most commonly reported sexually transmitted diseases (STDs) in the United States. Under limited budget, publicly funded clinics are not able to screen and treat the two diseases for all patients. They have to make a decision as to which group of population shall go through the procedure for screening and treating the two diseases. Therefore, we propose a cubic integer programming model on maximizing the number of units of cured diseases. At the same time, a two-step algorithm is established to solve the cubic integer program. We f
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26

Abbas-Ghavimi, Khosro. "Molecular epidemiology of Neisseria gonorrhoeae in Scotland." Thesis, University of Aberdeen, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400672.

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The incidence of Gonococcal infection in Grampian region was the highest in Scotland in 1992, 1993 and 1994.  Despite a considerable decrease in 1994, it remained more than twice that of the whole country. Grampian also differed from other regions in that 1A isolates were commoner, accounting for around 78%, 73% and 75% of isolates; the 1A-2 serovar was particularly common. The proportion of 1B isolates in Grampian (22%, 27% and 25%) was low compared with the other centres where 1B accounted for around 70% of all isolates (Young & Moyes, 1996). Seventy-six 1992, 1993 and 1994 clinical isolates
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27

Hopper, Amanda Clare. "The electron transfer chains of Neisseria gonorrhoeae." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3280/.

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\(Neisseria gonorrhoeae\) is an obligate human pathogen that can use both oxygen and nitrite as electron acceptors, but its electron transfer chain has only been partially characterised. The gonococcus encodes one azurin, Laz, and eight c-type cytochromes. The aim of this project was to determine the functions of these redox proteins. Single mutants lacking cytochromes c2, c4 and c5 reduced oxygen at 126%, 84% and 80% of the parental rate, respectively. It was not possible to construct a double mutant defective in both cytochromes c4 and c5, unless an ectopic copy of cytochrome c5 was present,
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28

De, Jongh Mari. "Studies on local isolates of neisseria gonorrhoeae:role in different clinical populations antimicrobial profile and mechanisms of resistance." Thesis, University of Limpopo (Medunsa Campus), 2010. http://hdl.handle.net/10386/277.

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Thesis (PhD Med.(Microbiology))--University of Limpopo, 2010.<br>Studies were performed on local isolates of Neisseria gonorrhoeae to assess their aetiological role in different clinical populations, to determine the evolution of antimicrobial resistance and characterisation of quinolone resistance. In the study performed on women presenting for termination of pregnancy (TOP) the prevalence of common sexually transmitted pathogens (Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis) was much higher than reported from other studies in TOP populations. The commonest org
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29

Lindbäck, Emma. "Mechanisms of resistance to ciprofloxacin in Neisseria gonorrhoeae." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-688-3/.

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30

Ellis, Charles David. "Studies on the inflammatory response to Neisseria gonorrhoeae." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391950.

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31

Chekir-Ghedira, Leila. "Génétique de la lectine adhésine de Neisseria gonorrhoeae." Lyon 1, 1991. http://www.theses.fr/1991LYO1T066.

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32

Reid, Katherine Gregor. "Characterisation and non-cultural detection of Neisseria gonorrhoeae." Thesis, University of Edinburgh, 1985. http://hdl.handle.net/1842/20141.

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33

Kan, Man-yee Elsie. "Application of neisseria gonorrhoeae molecular typing techniques in forensic medicine." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31971854.

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34

Francis, Finola. "Transcriptional analysis of cell division genes in Neisseria gonorrhoeae." Thesis, University of Ottawa (Canada), 1998. http://hdl.handle.net/10393/4507.

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This work represents the first study of the regulation of cell division genes in the Gram negative coccus Neisseria gonorrhoeae, and this regulation was studied under aerobic and anaerobic growth conditions using two different gonococcal strains: CH811 and FA1090. Three different clusters of cell division genes were investigated: the mur-fts cluster, the ftsEX cluster, and the min cluster corresponding to homologues at the 2 min, the 78 min, and the 26 min region of the Escherichia coli chromosome, respectively. Driven by initial DNA sequencing of the pivotal cell division gene ftsZ in our lab
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35

Picard, François J. "Genetics of arginine and proline biosynthesis in Neisseria gonorrhoeae." Thesis, University of Ottawa (Canada), 1991. http://hdl.handle.net/10393/7669.

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The carAB operon from E. coli hybridized with the gonococcal clones carrying carA or carB genes under conditions of high stringency (i.e. detecting approximately 80% or greater similarity) suggesting that the nucleotide sequence of the carbamoylphosphate synthetase genes is very similar in these two organisms. Under these conditions for hybridization, the gonococcal clones carrying argB or argF genes did not hybridize with plasmids containing the corresponding E. coli gene. Hybridizations performed under conditions of lower stringency indicate that the nucleotide sequence of the argB gene is l
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36

Chamberlain, Lisa M. "Pathogenesis and immunity in experimental infection with Neisseria gonorrhoeae." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320009.

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37

Turner, Susan Margaret. "Characterisation of novel cytochrome c lipoproteins in Niesseria gonorrhoeae." Thesis, University of Birmingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403008.

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38

Sullivan, Kevin Michael. "The restriction and modification genes of Neisseria gonorrhoeae P9." Thesis, University of Liverpool, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316753.

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39

Jensen, Alas Gabriel. "Detektion av ciprofloxacin-resistens hos Neisseria gonorrhoeae med PCR." Thesis, Malmö universitet, Fakulteten för hälsa och samhälle (HS), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-18755.

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Neisseria gonorrhoeae (NG) har successivt utvecklat resistens mot många antimikrobiella medel och betraktas som ett av de tre reella hoten bland antibiotikaresistenta bakterier. Ciprofloxacin är ett bredspektrum-antibiotikum tillhörande gruppen kinoloner som, förutom att behandla urinvägsinfektioner, används mot NG och infektioner i mage och tarm. Dock har det rapporterats att ca 30 % av NG-isolat som samlats in genom gonokock-isolatövervakningsprojekt (GISP) under 2017 var resistenta mot ciprofloxacin. På molekylnivå är resistens mot ciprofloxacin starkt associerad med en enda mutation i kodo
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40

Dickinson, Mary Kathryne. "Characterization of TonB-Dependent Metal Transporters within Neisseria gonorrhoeae." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3502.

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Neisseria gonorrhoeae, the etiologic agent of gonorrhea, utilizes TonB-dependent transporters to import essential nutrients such as iron. Study of TonB-dependent transporters is extremely important due to the fact that they make excellent vaccine targets. In order to learn more about the structure, function, expression, and regulation of selected TonB-dependent transporters, three goals were established for this study. The first goal was to examine the role of two highly conserved regions of TbpB in lipidation. One of the conserved regions of TbpB, the LSAC motif, was shown to be critical for
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41

Bilek, Nicole. "Genetic mechanisms of opa gene variation in Neisseria gonorrhoeae." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/6210.

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To understand the rates and mechanisms of Neisseria gonorrhoeae opacity (opa) gene variation, the 11 opa genes were amplified independently so that an opa allelic profile could be defined for any isolate from the sequences at each locus. Initial examination of 14 unrelated gonococcal isolates showed that no opa alleles were shared. Analysis of closely related isolates showed these typically shared most opa alleles and so the mechanisms by which recent changes occurred at individual opa loci could be determined. The great majority of changes were due to recombination among existing alleles that
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42

Coghill, Diane Vivien. "Monoclonal antibodies against Neisseria Gonorrhoeae : serotyping and diagnostic applications." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/27815.

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The aims of this study were (i) to investigate the value of newly developed monoclonal antibody coagglutination reagents for serotyping gonococci according to Protein I variation between strains; (ii) to determine if these or similar monoclonal antibodies could be used in an immunological method for the non -cultural detection of N. gonorrhoeae; and (iii) to produce monoclonal antibodies directed against gonococcal beta- lactamase and to examine their value in a non - cultural diagnostic test for penicillinase- producing gonococci. A total of 1201 gonococcal isolates, obtained from 967 patient
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43

Seow, Vui Yin. "DNA Transformation and Type IV Pili in Neisseria gonorrhoeae." Electronic Thesis or Diss., Sorbonne université, 2024. http://www.theses.fr/2024SORUS049.

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La résistance aux antibiotiques, évidente chez des souches telles que Neisseria gonorrhoeae, est une crise sanitaire mondiale. Il est vital de comprendre son mécanisme, en particulier la transformation naturelle par les Pili de type IV de ces bactéries. Bien qu'elle ait été découverte en 1928, la transformation naturelle n'a toujours pas été élucidée. La dépendance de Neisseria gonorrhoeae à l'égard des Pili de type IV en fait un modèle idéal pour l'étude de ce processus.Cette thèse se lance dans une exploration intensive des processus complexes de transformation de l'ADN au sein de Neisseria
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44

Johansson, Linda. "Host responses and bacterial virulence factors in Neisseria infections /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-017-6/.

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45

Seib, Kate Louise. "Defences against oxidative stress in Neisseria gonorrhoeae and Neisseria meningitidis /." St. Lucia, Qld, 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18015.pdf.

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46

Hauf, Eva. "Untersuchungen zum mitochondrialen Import des Hauptaußenmembranproteins PorB von Neisseria gonorrhoeae." Giessen : VVB Laufersweiler, 2007. http://geb.uni-giessen.de/geb/volltexte/2007/4750/index.html.

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47

thew, Francis Matthew Francis. "Investigating antimicrobial resistance mechanisms in Neisseria gonorrhoeae using peptide probes." Thesis, Durham University, 2009. http://etheses.dur.ac.uk/185/.

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The continuing evolution of antibiotic resistance strains of Neisseria gonorrhoeae coupled with the paucity of new antimicrobial agents makes the treatment of gonococcal infections challenging. A major cause of resistance is the expression of a multidrug efflux pump termed MtrCDE, which exports a wide range of antimicrobial agents. Efflux pumps are membrane-bound systems and consequently challenging to study and target with drugs. The transcriptional regulator (MtrR) of the efflux pump, however, is a soluble protein and therefore more amenable to study and drug target validation investigations
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48

Kan, Man-yee Elsie, and 簡文意. "Application of neisseria gonorrhoeae molecular typing techniques in forensic medicine." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31971854.

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49

Howard, Andrew John. "The penicillin binding proteins and beta-lactamases of Neisseria gonorrhoeae." Thesis, University of Nottingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336169.

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50

Lear, A. L. "O-acetylation and cross-linking of peptidoglycan in Neisseria gonorrhoeae." Thesis, University of Liverpool, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377120.

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