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Journal articles on the topic 'Gonorrhoea'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

DE, Bitet. "Neisseria Gonorrheae: A Cause of Male Infertility." Open Access Journal of Microbiology & Biotechnology 6, no. 1 (2021): 1–7. http://dx.doi.org/10.23880/oajmb-16000183.

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Background: Gonorrhoea is a sexually transmitted infection that is commonly related to male infertility. The infection affects sperm transport through the urinary tract and subsequent damage of the testicular tubes. The infection also impair sperm production as the infection is rarely asymptomatic and can be difficult to diagnose, it is possible that its contribution to male infertility is underestimated. Infection of the genitals results in a purulent (pus-like) discharge from the genitals which may be foul smelling, inflammation, redness, swelling, dysuria, and a burning sensation during uri

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2

Pham, Cau D., Kevin Pettus, Evelyn E. Nash, et al. "Utility of MALDI-TOF MS for differentiation of Neisseria gonorrhoeae isolates with dissimilar azithromycin susceptibility profiles." Journal of Antimicrobial Chemotherapy 75, no. 11 (2020): 3202–8. http://dx.doi.org/10.1093/jac/dkaa303.

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Abstract Background Antibiotic-resistant gonorrhoea has been a chronic public health burden since the mid-1930s. Recent emergence of isolates resistant to the current recommended antibiotics for gonorrhoea further magnifies the threat of untreatable gonorrhoea. The lack of new, effective antibiotics highlights the need for better understanding of the population structure of Neisseria gonorrhoeae in order to provide greater insight on how to curtail the spread of antimicrobial-resistant N. gonorrhoeae. Objectives To explore a potential application of MALDI-TOF MS to differentiate N. gonorrhoeae

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3

Chen, Xiang-Sheng, Yue-Ping Yin, Guo-Jun Liang, et al. "Co-infection with genital gonorrhoea and genital chlamydia in female sex workers in Yunnan, China." International Journal of STD & AIDS 17, no. 5 (2006): 329–32. http://dx.doi.org/10.1258/095646206776790088.

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An observational study on prevalence of co-infection with gonorrhoea and chlamydia was conducted among female sex workers (FSWs) in Kunming, China. A total of 505 FSWs participated in the study. All eligible participants gave informed consent. Demographic, behavioural and clinical information of the participants was gathered by direct structured interviews. Tampon swabs were collected to test for Chlamydia trachomatis and Nesseria gonorrhoeae. One-hundred and twenty-four (24.6%) FSWs were co-infected with these two pathogens. Of the 191 FSWs with gonorrhea, 124 (64.9%, 95% confidence interval

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4

Balachandran, T., A. P. Roberts, B. A. Evans, and B. S. Azadian. "Single-Dose Therapy of Anogenital and Pharyngeal Gonorrhoea with Ciprofloxacin." International Journal of STD & AIDS 3, no. 1 (1992): 49–51. http://dx.doi.org/10.1177/095646249200300112.

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A single dose of ciprofloxacin, 250 mg by mouth, was used in an open study to treat pharyngeal or rectal gonorrhoea or both in 64 patients (32 men and 32 women). The study also included 151 men with urethral gonorrhoea and 53 women with cervical or urethral gonorrhoea. Ciprofloxacin cured 63 (98%) patients with pharyngeal or rectal gonorrhoea (including 5 patients with penicillinase-producing Neisseria gonorrhoeae; PPNG), 147 (97%) men with urethral gonorrhoea (including 8 with PPNG) and 52 (98%) women with cervical or urethral gonorrhoea. All the isolates of N. gonorrhoeae were sensitive to 0

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Martins, José Luis Rodrigues, Emerith Mayra Hungria Pinto, Salomão Antonio Oliveira, Fernanda Almeida Costa Gomes, and Osmar Nascimento Silva. "Treatment of Sexually Transmitted Infections (STIs) Caused by Neisseria gonorrhoeae and the Global Shortage of Antibiotics." Venereology 1, no. 3 (2022): 235–44. http://dx.doi.org/10.3390/venereology1030017.

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The gonorrhoea caused by the bacterium Neisseria gonorrhoeae remains a major global public health problem with high morbidity. Gonorrhoea can affect both women and men, being more prevalent in sexually active young individuals. Even after infection from N. gonorrhoeae, many patients may remain asymptomatic, making the diagnosis and adequate treatment of the disease difficult. The treatment and control of gonorrhoea have been difficult in recent years in most populations, being an example of how behavioural, social, and demographic factors can influence the epidemiology of an infectious disease

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6

Rahimi, Frashta, Namraj Goire, Rebecca Guy, et al. "Direct urine polymerase chain reaction for chlamydia and gonorrhoea: a simple means of bringing high-throughput rapid testing to remote settings?" Sexual Health 10, no. 4 (2013): 299. http://dx.doi.org/10.1071/sh12108.

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Background Rapid point-of-care tests (POCTs) for chlamydia (Chlamydia trachomatis) and gonorrhoea (Neisseria gonorrhoeae) have the potential to confer health benefits in certain populations even at moderate sensitivities; however, suitable POCTs for these organisms are currently lacking. Methods: In this study, we investigated the use of direct urine polymerase chain reaction (PCR), with the view of implementing a simplified PCR strategy for high-throughput chlamydia and gonorrhoea screening in remote settings. Briefly, a simple dilution of the urine was performed before adding it directly to

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7

Semchenko, Evgeny A., Xiaofan Chen, Caroline Thng, Maree O'Sullivan, and Kate L. Seib. "Gonorrhoea: past, present and future." Microbiology Australia 41, no. 4 (2020): 205. http://dx.doi.org/10.1071/ma20055.

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The sexually transmitted infection (STI) gonorrhoea is an ancient human disease caused by the Gram-negative bacterial pathogen Neisseria gonorrhoeae. Despite decades of research focused on preventing, diagnosing, and treating gonorrhoea, it remains a major global health concern due to its high prevalence, high rates of asymptomatic cases, the severe sequelae that can result from untreated infections, and the increasing difficulty in treating infections caused by multi-drug resistant strains of N. gonorrhoeae. It is estimated that there are more than 87 million cases of gonorrhoea worldwide eac

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8

Kumar, Mr Ajay, Dr Shailesh Jain, Dr Dhanraj Patidar, Mr Ritesh Raj, and Mr Surendra Kumar Shah. "A Synopsis of Developing Diagnosis and Treatment for Gonorrhoea: Takeaways." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 640–52. https://doi.org/10.35629/4494-1002640652.

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The progressive decline in sensitivity of Neisseria gonorrhoeae to the medicines indicated for treatment has prompted worries about the public health hazard of antibiotic-resistant gonorrhoea. This is not a novel mechanism, as the organism has consistently evolved resistance to all current antibiotics used in therapy since the beginning of the antibiotic era. However, the history of modifying gonorrhoea therapy recommendations is complex, with diagnostic test techniques and surveillance influencing the process. Understanding the impact of these variables may shed light on current attempts to a

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9

Templeton, David J., Niveditha Manokaran, and Catherine C. O'Connor. "Prevalence and predictors of chlamydia co-infection among patients infected with gonorrhoea at a sexual health clinic in Sydney." Sexual Health 9, no. 4 (2012): 392. http://dx.doi.org/10.1071/sh11146.

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Anogenital gonorrhoea (Neisseria gonorrhoeae) is commonly diagnosed at sexual health clinics by on-site microscopy. Whether to add anti-chlamydial therapy in such situations is unclear. The medical records of all patients diagnosed with gonorrhoea between May 2005 and April 2010 at RPA Sexual Health were reviewed. Of 165 patients with anogenital gonorrhoea, 27 (16.4%, 95% confidence interval (CI) 11.1–22.9%) were co-infected with chlamydia (Chlamydia trachomatis). Compared with those only infected with anogenital gonorrhoea, there was no correlation of anogenital gonorrhoea–chlamydia co-infect

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10

Abraha, Million, Dianne Egli-Gany, and Nicola Low. "Epidemiological, behavioural, and clinical factors associated with antimicrobial-resistant gonorrhoea: a review." F1000Research 7 (March 27, 2018): 400. http://dx.doi.org/10.12688/f1000research.13600.1.

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Antimicrobial-resistant Neisseria gonorrhoeae is a global public health problem in the 21st century. N. gonorrhoeae has developed resistance to all classes of antibiotics used for empirical treatment, and clinical treatment failure caused by extensively resistant strains has been reported. Identifying specific factors associated with an increased risk of antimicrobial-resistant N. gonorrhoeae might help to develop strategies to improve antimicrobial stewardship. In this review, we describe the findings of 24 studies, published between 1989 and 2017, that examined epidemiological, behavioural,

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Tabize Olivier, Mutendela, Freddy Munyololo Muganza, Leshweni Jeremia Shai, and Stanley Sechene Gololo. "Rutin Inhibits F, G, N and O gonorrhea strains, 2008 WHO N-gonorrhea Reference strains, in vitro." Interdisciplinary Research Journal and Archives 1 (December 16, 2020): 41–49. http://dx.doi.org/10.36966/irjar2020.13.

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Rutin was isolated from methanol extract of the aerial part of Asparagus suaveolens using precipitation method. South Africans use Asparagus suaveolens to treat gonorrhea infections. The obtained Nuclear Magnetic Resonance (NMR) and Liquid Chromatography-Mass Spectroscopy (LC-MS) data and visiting the published data on the isolation of rutin confirmed the structure. The 2008 WHO Neisseria gonorrhea reference strains were used to evaluate microbial activity of rutin against the gonorrhea strains. Rutin found to be bacteriostatic against WHO 2008 Neisseria gonorrhoea F, G, N and O strains with t

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12

McMillan, A., H. Young, and A. Moyes. "Rectal Gonorrhoea in Homosexual Men: Source of Infection." International Journal of STD & AIDS 11, no. 5 (2000): 284–87. http://dx.doi.org/10.1177/095646240001100502.

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The objective of this retrospective study was to determine the possible source of infection in homosexual men with rectal gonorrhoea: the probable source of rectal gonorrhoea was identified in 46/155 cases. Although the urethra was the site of infection in 33 (72%) of these contacts, only pharyngeal gonorrhoea was identified in 9 (20%) men. In 25/26 cases, there was concordance in the auxo/serotypes of Neisseria gonorrhoeae between contacts with urethral gonorrhoea and the index men with rectal gonorrhoea. Eleven out of 12 pharyngeal isolates were of the same auxo/serotype as the index cases.

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13

Lewis, David A. "New treatment options for Neisseria gonorrhoeae in the era of emerging antimicrobial resistance." Sexual Health 16, no. 5 (2019): 449. http://dx.doi.org/10.1071/sh19034.

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Neisseria gonorrhoeae, the causative agent of gonorrhoea, has rapidly evolved from an exquisitely susceptible pathogen into a ‘superbug’ with the capacity to exhibit an extensively drug resistant (XDR) phenotype. The threat of untreatable gonorrhoea now looms on the horizon while the arsenal of effective antimicrobial agents diminishes with time. Ceftriaxone remains the mainstay of first-line therapy as a single agent or as the backbone of a dual therapy regimen. The implementation of new assays to facilitate ‘precision’ treatment, based on the prediction of N. gonorrhoeae susceptibility to ol

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Qiu, Jiayue. "Past And Current Vaccine Development Effort of Gonorrhea." Highlights in Science, Engineering and Technology 74 (December 29, 2023): 1661–66. http://dx.doi.org/10.54097/y6map040.

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Neisseria gonorrhea causes gonorrhoea, which is one of the sexually transmitted infections (STI) diseases that can affect the health of women, men, and neonates. Reflecting on its history of treatment, the development and distribution of a vaccine hold significant potential for mitigating the impact of this disease, especially in vulnerable populations. However, developing a novel vaccine for Neisseria gonorrhoeae has posed considerable challenges. This is primarily due to the Gonorrhea's antigenic variation, rendering it difficult for the human immune system to identify. Neisseria Gonorrhea i

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15

Read, Tim R. H., Marcus Y. Chen, Catriona S. Bradshaw, Sriyakantha Beneragama, and Christopher K. Fairley. "Do all women attending urban sexual health services need testing for gonorrhoea?" Sexual Health 2, no. 4 (2005): 259. http://dx.doi.org/10.1071/sh05029.

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Asymptomatic women are often screened for gonorrhoea at Australian sexual health centres. The medical records of all women diagnosed with gonorrhoea at the Melbourne Sexual Health Centre (MSHC) between January 2002 and December 2003 were audited and the database was examined for risk factors in all women tested in 2003. Fifteen cases of gonorrhoea were identified among women at MSHC, all had symptoms or an identifiable risk factor. Asymptomatic women without risk factors may not require screening for Neisseria gonorrhoeae in low prevalence populations.

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16

Xu, Xianglong, Eric P. F. Chow, Jason J. Ong, et al. "Modelling the potential role of saliva use during masturbation in the transmission of." Sexual Health 18, no. 6 (2021): 466–74. http://dx.doi.org/10.1071/sh21138.

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Background Neisseria gonorrhoeae can be cultured from saliva in men with pharyngeal gonorrhoea and could theoretically be transmitted from the pharynx to the urethra when saliva is used as a lubricant for masturbation. In this work, we proposed that saliva use during masturbation may be a potential transmission route of gonorrhoea. Methods We analysed the transmission of Neisseria gonorrhoeae at the oropharynx, urethra and anorectum with mathematical models among men who have sex with men using data from six different studies. Model 1 included transmission routes (oral sex, anal sex, rimming,

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Horner, P. J., R. J. Coker, A. Turner, M. S. Shafi, and S. M. Murphy. "Gonorrhoea: Signs, Symptoms and Serogroups." International Journal of STD & AIDS 3, no. 6 (1992): 430–33. http://dx.doi.org/10.1177/095646249200300606.

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Over 19 weeks, 104 male patients attending a genitourinary medicine clinic with gonococcal urethritis were asked to complete a questionnaire detailing symptoms. Sixty-seven questionnaires were duly completed. The examining nurse documented signs. Ninety-one isolates of Neisseria gonorrhoeae were serogrouped and auxotyped, 55 of these were from patients who had completed a questionnaire. Patients presented earlier if they had a past history of gonorrhoea ( p=0.02). The serogroup of N. gonorrhoeae did not influence the amount of discharge, the presence of meatal inflammation, dysuria or penile t

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Somayaji, R., C. Naugler, M. Guo, and D. Church. "Examining Chlamydia trachomatis and Neisseria gonorrhoeae rates between 2010 and 2015: a population-based observational study." International Journal of STD & AIDS 28, no. 8 (2016): 822–28. http://dx.doi.org/10.1177/0956462416674427.

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Bacterial sexually transmitted infections including Chlamydia trachomatis and Neisseria gonorrhoeae remain an important public health concern. We aimed to assess the population-based incidence of C. trachomatis and N. gonorrhoeae in an age-standardized cohort over time. A retrospective study of a large Canadian health region was undertaken between 2010 and 2015 using linked census and digital laboratory data. C. trachomatis and N. gonorrhoeae tests were linked to patient data. Sex and age-standardized incidence rates (IR) and ratios (IRR) were calculated for cases and testing rates. The annual

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Qian, Sue, Rosalind Foster, Christopher Bourne, Tobias Vickers, Ruthy McIver, and Anna McNulty. "Neisseria gonorrhoeae positivity in clients presenting as asymptomatic contacts of gonorrhoea at a sexual health centre." Sexual Health 17, no. 2 (2020): 187. http://dx.doi.org/10.1071/sh19091.

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Background Previous guidelines at the Sydney Sexual Health Centre (SSHC) recommended empirical antibiotic treatment for asymptomatic contacts of Neisseria gonorrhoeae at the time of testing. With increasing concerns around gonorrhoea antibiotic resistance, it has been suggested that asymptomatic contacts should only be treated based on test results. Methods: This retrospective study of data from the SSHC electronic medical record included a total of 295 gonorrhoea contacts from 1 January 2018 to 30 June 2018. The primary outcome was the proportion of asymptomatic gonorrhoea contacts with a pos

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Semchenko, Evgeny A., Aimee Tan, Ray Borrow, and Kate L. Seib. "The Serogroup B Meningococcal Vaccine Bexsero Elicits Antibodies to Neisseria gonorrhoeae." Clinical Infectious Diseases 69, no. 7 (2018): 1101–11. http://dx.doi.org/10.1093/cid/ciy1061.

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Abstract Background Neisseria gonorrhoeae and Neisseria meningitidis are closely-related bacteria that cause a significant global burden of disease. Control of gonorrhoea is becoming increasingly difficult, due to widespread antibiotic resistance. While vaccines are routinely used for N. meningitidis, no vaccine is available for N. gonorrhoeae. Recently, the outer membrane vesicle (OMV) meningococcal B vaccine, MeNZB, was reported to be associated with reduced rates of gonorrhoea following a mass vaccination campaign in New Zealand. To probe the basis for this protection, we assessed the cross

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Unemo, Magnus, Monica M. Lahra, Michelle Cole, et al. "World Health Organization Global Gonococcal Antimicrobial Surveillance Program (WHO GASP): review of new data and evidence to inform international collaborative actions and research efforts." Sexual Health 16, no. 5 (2019): 412. http://dx.doi.org/10.1071/sh19023.

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Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a serious public health problem, compromising the management and control of gonorrhoea globally. Resistance in N. gonorrhoeae to ceftriaxone, the last option for first-line empirical monotherapy of gonorrhoea, has been reported from many countries globally, and sporadic failures to cure especially pharyngeal gonorrhoea with ceftriaxone monotherapy and dual antimicrobial therapies (ceftriaxone plus azithromycin or doxycycline) have been confirmed in several countries. In 2018, the first gonococcal isolates with ceftriaxone resistance pl

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Suryowati, Trini. "Neisseria Gonorrhoeae: Its Dominant Properties to Establish Contact and Attachment that Facilitate Epithelial Invasion and Colonization From a Biochemist Perspective." Asian Journal of Biochemistry, Genetics and Molecular Biology 15, no. 3 (2023): 82–90. http://dx.doi.org/10.9734/ajbgmb/2023/v15i3341.

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Aim: to discuss recent epidemiology of gonorrhoea and updates regarding its pathogenesis with a focus on biochemical aspects of contact and adhesion that preceded its epithelial invasion. Discussion: Neisseria gonorrhoeae, a Gram-negative obligate human pathogenic bacterium, infects human epithelial cells and causes sexually transmitted diseases in both males and females Gonorrhea rates are rising in many countries. It could lead to long-term health problems and even infertility. Vulnerable groups including men who have sex with men and sex workers appear to bear disproportionate burdens

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Mabonga, Emily, Rosalind Parkes-Ratanshi, Stefan Riedel, et al. "Complete ciprofloxacin resistance in gonococcal isolates in an urban Ugandan clinic: findings from a cross-sectional study." International Journal of STD & AIDS 30, no. 3 (2018): 256–63. http://dx.doi.org/10.1177/0956462418799017.

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Antimicrobial resistance (AMR) to gonorrhoea is a threat to global health security. There have been concerns expressed that countries with high rates of disease have poor surveillance. The objectives of the study were to determine the AMR patterns of Neisseria gonorrhoeae clinical isolates to antimicrobial agents in patients with HIV or high risk of HIV acquisition, to compare the concordance of disk diffusion and agar dilution as methods for determining AMR to N. gonorrhoeae, and to describe methodological challenges to carrying out AMR testing. The study was conducted at an HIV outpatient se

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Białecka, Joanna, Katarzyna Rak, and Aneta Kiecka. "Gonococci – Pathogens of Growing Importance. Part 1. Current Data on Diagnostics, Genotyping and Therapy." Advancements of Microbiology 63, no. 1 (2024): 3–14. http://dx.doi.org/10.2478/am-2024-0001.

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Abstract Neisseria gonorrhoeae is an aetiological agent of gonorrhoea, which is a sexually transmitted disease (STD), a public health challenge worldwide. Gonorrhoea is undoubtedly a serious health risk, especially for women, due to its often asymptomatic course and the possibility of upper genital tract complications such as pelvic inflammatory disease (PID), which can result in infertility. The data show that the diagnostic method for N. gonorrhoeae should be specific, simple, sensitive, rapid and inexpensive. Currently, phenotypic identification methods have been dominated by NAAT methods,

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Lopez, Kelsey M., Jeffrey A. Hobden, and Isiah M. Warner. "Octenidine/carbenicillin GUMBOS as potential treatment for oropharyngeal gonorrhoea." Journal of Antimicrobial Chemotherapy 75, no. 12 (2020): 3576–81. http://dx.doi.org/10.1093/jac/dkaa346.

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Abstract Background Reducing Neisseria gonorrhoeae colonies in the oropharynx is a viable solution to minimize the transmission of this bacterium amongst individuals. Objectives A strategy involving the electrostatic interaction between a common antiseptic and a discontinued antibiotic (i.e. octenidine and carbenicillin) was evaluated as a potential treatment for gonorrhoea. Octenidine/carbenicillin is a novel group of uniform materials based on organic salts (GUMBOS) with inherent in vitro antibacterial activity that comes from its parent antiseptic and antibacterial ions, octenidine and carb

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Grütter, Anabel E., Tecla Lafranca, Aurelia Pahnita Sigg, Max Mariotti, Gernot Bonkat, and Olivier Braissant. "Detection and Drug Susceptibility Testing of Neisseria gonorrhoeae Using Isothermal Microcalorimetry." Microorganisms 9, no. 11 (2021): 2337. http://dx.doi.org/10.3390/microorganisms9112337.

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Background: Gonorrhea is a frequently encountered sexually transmitted disease that results in urethritis and can further lead to pelvic inflammatory disease, infertility, and possibly disseminated gonococcal infections. Thus, it must be diagnosed promptly and accurately. In addition, drug susceptibility testing should be performed rapidly as well. Unfortunately, Neisseria gonorrhoea is a fastidious microorganism that is difficult to grow and requires culturing in an opaque medium. Methods: Here, we used isothermal microcalorimetry (IMC) to monitor the growth and the antimicrobial susceptibili

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Chigugudhlo, Patronellah Nelly, Evans Chazireni, Ian Takunda Marufu-Dzangare, and Simon Dhleleyeniec. "Temporal analysis of gonorrhoea prevalence rate in females aged 15-49 in Chipinge district, Zimbabwe." International Journal of Social Sciences and Humanities Invention 6, no. 1 (2019): 5214–17. http://dx.doi.org/10.18535/ijsshi/v6i1.01.

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This study was carried out to examine the temporal prevalence of gonorrhoea in females aged 15-49 in Chipinge district in Manicaland province of Zimbabwe. A mixed research design involving secondary data and focus group interviews was used in this study. Interview guides were used to collect primary data. The data collected was organized and was presented graphically. Findings from the study revealed that females aged 15 to 49 experienced high prevalence rate of gonorrhoea but the number of gonorrhoea cases was declining over the years. It emerged from the study that risk behaviours such as pr

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Liang, Jingyao, Ridong Yang, Xiaodong Li, et al. "First four failures of cefathiamidine to treat urogenital gonorrhoea in Guangzhou, China, 2014–15." Sexual Health 14, no. 3 (2017): 289. http://dx.doi.org/10.1071/sh16087.

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Neisseria gonorrhoeae has a remarkable ability to develop resistance to all available therapeutic antimicrobials. This report describes the first four cases of verified failure to treat gonorrhoea using 1000 mg cefathiamidine intramuscularly in Guangzhou, China; for each case, the patient was clinically cured after treatment with 500 mg ceftriaxone intramuscularly. Enhanced monitoring of clinical treatment failures, finding new effective treatments and updating treatment guidelines are all of utmost importance to curb the spread of drug-resistant gonorrhoea.

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Hansen, Lisa, Tom Wong, and Maureen Perrin. "Gonorrhoea resurgence in Canada." International Journal of STD & AIDS 14, no. 11 (2003): 727–31. http://dx.doi.org/10.1258/09564620360719741.

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After several years of decline, reported gonorrhoea rates in Canada have recently increased substantially. National goals for gonorrhoea control were developed in 1997, but it appears that reliance on secular trends is insufficient to attain the goal of eliminating locally transmitted infection by Neisseria gonorrhoeae by 2010. We have examined disease surveillance reports from 1994 to 2001 inclusive to assess demographic and epidemiologic trends in reported cases of gonococcal infection. Since 1997, reported cases have increased by 53% among men and 33% among women. The largest proportion of

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Metelmann, Soeren, Alexander Thompson, Anna Donten, et al. "A systematic review to identify research gaps in studies modeling MenB vaccinations against Neisseria infections." PLOS ONE 20, no. 1 (2025): e0316184. https://doi.org/10.1371/journal.pone.0316184.

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The genus Neisseria includes two major human pathogens: N. meningitidis causing bacterial meningitis/septicemia and N. gonorrhoeae causing gonorrhoea. Mathematical models have been used to simulate their transmission and control strategies, and the recent observation of a meningococcal B (MenB) vaccine being partially effective against gonorrhoea has led to an increased modeling interest. Here we conducted a systematic review of the literature, focusing on studies that model vaccination strategies with MenB vaccines against Neisseria incidence and antimicrobial resistance. Using journal, prepr

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Ritchie, Stephen, Rebecca Henley, Jackie Hilton, et al. "Uptake, yield and resource requirements of screening for asymptomatic sexually transmissible infections among HIV-positive people attending a hospital outpatient clinic." Sexual Health 11, no. 1 (2014): 67. http://dx.doi.org/10.1071/sh13167.

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Background We performed a prospective audit of screening for asymptomatic sexually transmissible infections (STIs), during an intensive effort to screen all patients at our hospital-based HIV clinic. We aimed to measure the effectiveness and resource implications of our screening program. Methods: All outpatients who attended during an 8-month period were invited to take part in opt-out screening for chlamydia (Chlamydia trachomatis), gonorrhoea (Neisseria gonorrhoeae) and syphilis. Participants completed a brief questionnaire, were asked about current symptoms of STIs and self-collected speci

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Chesson, Harrell W., Kwame Owusu-Edusei, Jami S. Leichliter, and Sevgi O. Aral. "Violent crime rates as a proxy for the social determinants of sexually transmissible infection rates: the consistent state-level correlation between violent crime and reported sexually transmissible infections in the United States, 1981–2010." Sexual Health 10, no. 5 (2013): 419. http://dx.doi.org/10.1071/sh13006.

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Background Numerous social determinants of health are associated with violent crime rates and sexually transmissible infection (STI) rates. This report aims to illustrate the potential usefulness of violent crime rates as a proxy for the social determinants of STI rates. Methods: For each year from 1981 to 2010, we assessed the strength of the association between the violent crime rate and the gonorrhoea (Neisseria gonorrhoeae) rate (number of total reported cases per 100 000) at the state level. Specifically, for each year, we calculated Pearson correlation coefficients (and P-values) between

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Boiko, Iryna, Viorika Akimova, Lyudmyla Mazur, Iryna Savchenko, Ihor Kohut, and Inna Krynytska. "The Clinico-Epidemiological Profile of Patients with Gonorrhoea and Challenges in the Management of Neisseria gonorrhoeae Infection in an STI clinic, Ternopil, Ukraine (2013-2018)." Journal of Medicine and Life 13, no. 1 (2020): 75–81. http://dx.doi.org/10.25122/jml-2019-0170.

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Gonorrhea is the second most common sexually transmitted infection spreading worldwide and a serious public health problem. How�ever, further data are required to improve the management of gonorrhea. Our aim was to review the features of gonococcal infection and characterize the challenges of its management. A retrospective descriptive study of the medical records of 136 adult patients with gonorrhea that visited Ternopil Regional Sexually Transmitted Infections Clinic (Ukraine) in 2013-2018 was performed. The male-to-female ratio was 6.6:1. Homosexually-acquired gonorrhoea was 3.7%. Also, mos

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Dubbink, Jan Henk, Stephan P. Verweij, Helen E. Struthers, et al. "Genital Chlamydia trachomatis and Neisseria gonorrhoeae infections among women in sub-Saharan Africa: A structured review." International Journal of STD & AIDS 29, no. 8 (2018): 806–24. http://dx.doi.org/10.1177/0956462418758224.

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Chlamydia trachomatis and Neisseria gonorrhoeae constitute major public health problems among women, but the burden of infection in sub-Saharan Africa is poorly documented. We conducted a structured review of the prevalence and incidence of genital, oral and anal C. trachomatis and N. gonorrhoeae infection in women in sub-Saharan Africa. We searched Medline, EMBASE and Web of Science over a 10-year period for studies on epidemiology of genital, oral and anal chlamydial infection and gonorrhoea in women in all countries of sub-Saharan Africa. We assessed geographic and demographic differences i

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Chow, Eric P. F., Christopher K. Fairley, and Fabian Y. S. Kong. "STI pathogens in the oropharynx: update on screening and treatment." Current Opinion in Infectious Diseases 37, no. 1 (2023): 35–45. http://dx.doi.org/10.1097/qco.0000000000000997.

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Purpose of review The rise in antimicrobial resistance in several STI pathogens such as Neisseria gonorrhoeae has become a public health threat as only one first-line treatment remains. Reducing screening interval for gonorrhoea and chlamydia in high-prevalence populations has been proposed to address antimicrobial stewardship, but this remains controversial. This review aimed to revisit the epidemiology of infections at the oropharynx and review the current screening recommendations and treatment guidelines in different populations. Recent findings Emerging evidence suggests that the orophary

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Prameshwara, Almarissa Ajeng, Vidyadhari Puspa Prawarni, Devi Artami Susetiati, and Titik Nuryastuti. "Ceftriaxone-and-cefixime-resistant Neisseria gonorrhoeae in a 26-year-old-male with gonococcal urethritis: a case report." Journal of Clinical Microbiology and Infectious Diseases 4, no. 2 (2024): 54–57. https://doi.org/10.51559/jcmid.v4i2.68.

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Introduction: Gonorrhoea is the most prevalent sexually transmitted infection (STI) in Indonesia. The increasing resistance of Neisseria gonorrhoeae to antibiotics has prompted the World Health Organization (WHO) to classify gonorrhoea as an urgent public health threat. Reports of resistance to third generation extended-spectrum cephalosporins (ESCs), such as cefixime and ceftriaxone, against N. gonorrhoeae are rare in Indonesia. This study aims to present a case of cefixime and ceftriaxone resistance in a 26-year-old man with gonococcal urethritis. Case Description: A 26-year-old man presente

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Foerster, Sunniva, George Drusano, Daniel Golparian, et al. "In vitro antimicrobial combination testing of and evolution of resistance to the first-in-class spiropyrimidinetrione zoliflodacin combined with six therapeutically relevant antimicrobials for Neisseria gonorrhoeae." Journal of Antimicrobial Chemotherapy 74, no. 12 (2019): 3521–29. http://dx.doi.org/10.1093/jac/dkz376.

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Abstract Objectives Resistance in Neisseria gonorrhoeae to all gonorrhoea therapeutic antimicrobials has emerged. Novel therapeutic antimicrobials are imperative and the first-in-class spiropyrimidinetrione zoliflodacin appears promising. Zoliflodacin could be introduced in dual antimicrobial therapies to prevent the emergence and/or spread of resistance. We investigated the in vitro activity of and selection of resistance to zoliflodacin alone and in combination with six gonorrhoea therapeutic antimicrobials against N. gonorrhoeae. Methods The international gonococcal reference strains WHO F

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Kwong, Jason C., Eric P. F. Chow, Kerrie Stevens, et al. "Whole-genome sequencing reveals transmission of gonococcal antibiotic resistance among men who have sex with men: an observational study." Sexually Transmitted Infections 94, no. 2 (2017): 151–57. http://dx.doi.org/10.1136/sextrans-2017-053287.

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ObjectivesDrug-resistant Neisseria gonorrhoeae are now a global public health threat. Direct transmission of antibiotic-resistant gonococci between individuals has been proposed as a driver for the increased transmission of resistance, but direct evidence of such transmission is limited. Whole-genome sequencing (WGS) has superior resolution to investigate outbreaks and disease transmission compared with traditional molecular typing methods such as multilocus sequence typing (MLST) and N. gonorrhoeae multiantigen sequence (NG-MAST). We therefore aimed to systematically investigate the transmiss

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Xiong, Mingzhou, Peizhen Zhao, Xingzhong Wu, et al. "Gonorrhoea treatment guideline compliance and influence factors in Guangdong province, China: a cross-sectional survey." BMJ Open 14, no. 7 (2024): e084731. http://dx.doi.org/10.1136/bmjopen-2024-084731.

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BackgroundThe indiscriminate use of antibiotics has accelerated antimicrobial resistance (AMR) inNeisseria gonorrhoeae(NG), emphasising the need to follow treatment guidelines. This study aimed to assess the rate of adherence to standard treatment among patients with gonorrhoea and identify influencing factors.MethodsA survey was conducted in Guangdong province, China, involving uncomplicated gonorrhoea cases registered in the Chinese Information System for Disease Control and Prevention. Data on demographic characteristics and medical information were collected to determine the standard treat

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Gottlieb, Sami L., Ann E. Jerse, Sinead Delany-Moretlwe, Carolyn Deal, and Birgitte K. Giersing. "Advancing vaccine development for gonorrhoea and the Global STI Vaccine Roadmap." Sexual Health 16, no. 5 (2019): 426. http://dx.doi.org/10.1071/sh19060.

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Efforts to develop vaccines against Neisseria gonorrhoeae have become increasingly important, given the rising threat of gonococcal antimicrobial resistance (AMR). Recent data suggest vaccines for gonorrhoea are biologically feasible; in particular, epidemiological evidence shows that vaccines against a closely related pathogen, serogroup B Neisseria meningitidis outer membrane vesicle (OMV) vaccines, may reduce gonorrhoea incidence. Vaccine candidates using several approaches are currently in preclinical development, including meningococcal and gonococcal OMV vaccines, a lipooligosaccharide e

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Davies, P. O., and C. A. Ison. "The role of effective diagnosis for the control of gonorrhoea in high prevalence populations." International Journal of STD & AIDS 9, no. 8 (1998): 435–43. http://dx.doi.org/10.1258/0956462981922539.

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Gonorrhoea in the UK is now a highly focal problem that is localized to certain inner city areas where it presents a significant public health concern. However, the majority of men and a proportion of women infested with Neisseria gonorrhoeae do not experience symptoms of sufficient intensity to prompt them to seek medical advice and the current strategy of treating symptomatic individuals in specialist clinics with subsequent tracing of sexual partners is therefore failing to control the spread of infection in these areas. One method for addressing this problem would be the extension of effec

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Tapsall, John, and WHO Western Pacific Gonococcal AMR Surveillance Programme Krause. "Surveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific Region, 2001." Communicable Diseases Intelligence 26 (December 31, 2002): 541–45. https://doi.org/10.33321/cdi.2002.26.52.

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A long-term program of surveillance of antimicrobial resistance in Neisseria gonorrhoeae isolated in the World Health Organization's Western Pacific Region (WHO WPR GASP) continued in 2001. Seventeen focal points contributed data on about 10,000 gonococci. Resistance to quinolone and penicillin antibiotics remained widely dispersed and at high levels. Gonococci with decreased susceptibility to third generation cephalosporins were again observed in four centres. Spectinomycin resistance was infrequently encountered. Control of gonorrhoea in the WHO WPR is compromised by the further reduction in

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WHO Western Pacific Gonococcal AMR Surveillance Programme and JW Tapsall. "Surveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific Region, 1998." Communicable Diseases Intelligence 24 (January 20, 2000): 1–4. https://doi.org/10.33321/cdi.2000.24.1.

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Effective treatment of gonorrhoea in the World Health Organization's Western Pacific Region is hampered by the emergence and spread of antibiotic resistant strains of Neisseria gonorrhoeae. A programme of surveillance of gonococcal susceptibility to antibiotics (GASP) continued in the region in 1998. A high proportion of isolates in many participating countries was resistant to quinolones and penicillins, continuing trends observed by this programme since 1992. Resistance to the later generation cephalosporins and to spectinomycin was absent or infrequent. Options for effective treatment of go

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Tapsall, John, and WHO Western Pacific Gonococcal AMR Surveillance Programme Krause. "Surveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific Region, 2002." Communicable Diseases Intelligence 27 (December 31, 2003): 488–91. https://doi.org/10.33321/cdi.2003.27.77.

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The World Health Organization's Western Pacific Region (WHO WPR) long standing programme for surveillance of antimicrobial resistance in Neisseria gonorrhoeae, GASP, continued in 2002. Seventeen countries contributed data on about 11,500 gonococci by determining susceptibility patterns using standardised methodologies. Resistance to quinolone and penicillin antibiotics remained widely dispersed and at historically high levels. Gonococci with decreased susceptibility to third generation cephalosporins were again observed in several centres. Spectinomycin resistance was infrequently encountered.

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Wang, Ann Andee, and Elyse Anna Linson. "Septic arthritis in a previously healthy man with pan-negative infectious and rheumatologic work-up." BMJ Case Reports 13, no. 2 (2020): e231823. http://dx.doi.org/10.1136/bcr-2019-231823.

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Neisseria gonorrhoeae is the causative organism in 0.6%–1.2% of septic arthritis cases in North America and Europe, and classically presents as migratory polyarthralgias and tenosynovitis, with later development of septic oligoarthritis. In men, urine gonorrhoea nucleic amplification testing (NAAT) is the preferred diagnostic test, as its sensitivity surpasses that of joint and blood culture in disseminated infections. We present a case of a previously healthy man who presented with septic arthritis of the wrist. He denied any sexual activity in the previous year. Urine gonorrhoea NAAT and cul

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Kenyon, Chris, Jolein Laumen, and Sheeba Manoharan-Basil. "Choosing New Therapies for Gonorrhoea: We Need to Consider the Impact on the Pan-Neisseria Genome. A Viewpoint." Antibiotics 10, no. 5 (2021): 515. http://dx.doi.org/10.3390/antibiotics10050515.

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The development of new gonorrhoea treatment guidelines typically considers the resistance-inducing effect of the treatment only on Neisseria gonorrhoeae. Antimicrobial resistance in N. gonorrhoeae has, however, frequently first emerged in commensal Neisseria species and then been passed on to N. gonorrhoeae via transformation. This creates the rationale for considering the effect of gonococcal therapies on resistance in commensal Neisseria. We illustrate the benefits of this pan-Neisseria strategy by evaluating three contemporary treatment options for N. gonorrhoeae—ceftriaxone plus azithromyc

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Manavi, Kaveh, Hugh Young, and Dan Clutterbuck. "Sensitivity of microscopy for the rapid diagnosis of gonorrhoea in men and women and the role of gonorrhoea serovars." International Journal of STD & AIDS 14, no. 6 (2003): 390–94. http://dx.doi.org/10.1258/095646203765371277.

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Auditing the sensitivity of microscopic diagnosis of gonorrhoea is recommended by the current guidelines. A retrospective study was performed of 596 cases of positive cultures for Neisseria gonorrhoeae in modified New York City culture (MNYC) media diagnosed from 1995 to 1999. The sensitivity of the cervical slides in women was 51% while in men who have sex with men (MSM) the sensitivity of urethral and rectal slides were 89% and 54% respectively. The sensitivity of urethral slides in heterosexual men was 84%. Neisseria serovar 1B02 among MSM and serovar 1B31 among women were mostly undiagnose

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Mossenson, Adam, Kathryn Algie, Melanie Olding, Linda Garton, and Carole Reeve. "'Yes wee can' - a nurse-driven asymptomatic screening program for chlamydia and gonorrhoea in a remote emergency department." Sexual Health 9, no. 2 (2012): 194. http://dx.doi.org/10.1071/sh11064.

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Background A nurse-driven, urine-based screening program for Neisseria gonorrhoeae and Chlamyida trachomatis was conducted in a remote emergency department targeting asymptomatic youth. Methods: Individuals who presented to the Emergency Department with non-genitourinary complaints between the ages of 16 and 34 were offered free opportunistic urinary testing for gonorrhoea and chlamydia. Results: In total, 178 eligible patients were offered screening, 65% consented for testing and 14 patients (12%) returned positive results, with 10 diagnoses of chlamydia, 9 of gonorrhoea and 5 with both. Disc

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Valejo Coelho, Margarida Moura, Eugénia Matos-Pires, Vasco Serrão, Ana Rodrigues, and Cândida Fernandes. "Extragenital Gonorrhoea in Men Who Have Sex with Men: A Retrospective Study in a STI Clinic in Lisbon, Portugal." Acta Médica Portuguesa 31, no. 5 (2018): 247. http://dx.doi.org/10.20344/amp.10146.

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Introduction: Recent studies worldwide reveal a significant prevalence of extragenital infections by Neisseria gonorrhoeae among men who have sex with men. We aimed to analyse the frequency and characteristics of extragenital gonococcal infections diagnosed in men who have sex with men in a walk-in Sexually Transmitted Infection clinic in Lisbon, Portugal.Material and Methods: We conducted a cross-sectional, retrospective study of the anorectal and/or oropharyngeal Neisseria gonorrhoeae infections in men who have sex with men, diagnosed in our Sexually Transmitted Infection clinic between Janu

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Marangoni, Antonella, Giacomo Marziali, Melissa Salvo, et al. "Mosaic structure of the penA gene in the oropharynx of men who have sex with men negative for gonorrhoea." International Journal of STD & AIDS 31, no. 3 (2020): 230–35. http://dx.doi.org/10.1177/0956462419889265.

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The oropharynx represents a crucial site for the emergence of multi-drug resistance in Neisseria gonorrhoeae. The mosaic penA alleles, associated with decreased susceptibility to cephalosporins, have emerged by DNA recombination with partial penA genes, particularly those from commensal pharyngeal Neisseria species. Here, we investigated the prevalence of the mosaic structure of the penA gene in the oropharynx of men who have sex with men testing negative for pharyngeal gonorrhoea. From January 2016 to June 2018, 351 gonorrhoea-negative men who have sex with men attending a sexually transmitte

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