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Relevant bibliographies by topics / Gossypol – Toxicology

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Academic literature on the topic 'Gossypol – Toxicology'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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Journal articles on the topic "Gossypol – Toxicology"

1

Heywood, R. "The toxicology of gossypol acetic acid and (−)-gossypol." Contraception 37, no. 2 (1988): 185–90. http://dx.doi.org/10.1016/0010-7824(88)90129-1.

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2

Hong, C. Y., J. J. Huang, and P. Wu. "The Inhibitory Effect of Gossypol on Human Sperm Motility: Relationship with Time, Temperature and Concentration." Human Toxicology 8, no. 1 (1989): 49–51. http://dx.doi.org/10.1177/096032718900800109.

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The inhibitory effect of gossypol acetic acid on human sperm motility was studied with a transmembrane migration method. Gossypol decreased sperm motility after it had been incubated with semen for more than 15 min. However, when sperm motility was evaluated immediately after semen had been mixed with gossypol, no inhibitory effect could be found. We consider that the sperm immobilizing potency of gossypol is much less than our previously studied sperm immobilizing agents. It is unlikely that gossypol can be developed as a vaginal spermicide. The importance of time course in the pharmacologica

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3

Kitada, Shinichi, Christina L. Kress, Maryla Krajewska, Lee Jia, Maurizio Pellecchia, and John C. Reed. "Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2–transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048)." Blood 111, no. 6 (2008): 3211–19. http://dx.doi.org/10.1182/blood-2007-09-113647.

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Abstract Altered expression of Bcl-2 family proteins plays central roles in apoptosis dysregulation in cancer and leukemia, promoting malignant cell expansion and contributing to chemoresistance. In this study, we compared the toxicity and efficacy in mice of natural product gossypol and its semisynthetic derivative apo-gossypol, compounds that bind and inhibit antiapoptotic Bcl-2 family proteins. Daily oral dosing studies showed that mice tolerate doses of apogossypol 2- to 4-times higher than gossypol. Hepatotoxicity and gastrointestinal toxicity represented the major adverse activities of g

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4

Daneshmand, Mahsa, Jamileh Salar Amoli, and Tahereh Ali Esfahani. "A Comparative Study of the Cytotoxic Effects and Oxidative Stress of Gossypol on Bovine Kidney and HeLa Cell Lines." Iranian Journal of Toxicology 15, no. 3 (2021): 157–64. http://dx.doi.org/10.32598/ijt.15.3.795.1.

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Background: Cotton seed is one of the main sources of protein in animal feeds, containing gossypol, which has been shown to have toxic effects. Results reported by various studies also indicate the anti-cancer effects of gossypol on various cell types. However, its toxic effects on human and animal cells have not been fully established. This study was planned to investigate, for the first time, the cytotoxic effects and oxidative stress induced by gossypol on normal Bovine Kidney (BK) and HeLa cell lines, representing typical healthy and cancer cells, respectively. Methods: The BK and HeLa cel

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5

Wang, Wei-Kang, Yan-Lu Wang, Wen-Juan Li, Qi-Chao Wu, Sheng-Li Li, and Hong-Jian Yang. "Gossypol Exhibited Higher Detrimental Effect on Ruminal Fermentation Characteristics of Low-Forage in Comparison with High-Forage Mixed Feeds." Toxics 9, no. 3 (2021): 51. http://dx.doi.org/10.3390/toxics9030051.

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Gossypol is a key anti-nutritional factor which limits the feeding application of cottonseed by-products in animal production. A 2 × 4 factorial in vitro experiment was conducted to determine the effect of gossypol addition levels of 0, 0.25, 0.5, and 0.75 mg/g on ruminal fermentation of a high-forage feed (HF, Chinese wildrye hay/corn meal = 3:2) in comparison with a low-forage feed (LF, Chinese wildrye hay/corn meal = 2:3). After 48 h of incubation, in vitro dry matter disappearance was greater in the LF than the HF group, while the cumulative gas production and asymptotic gas production wer

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Beaudoin, Allan R. "The embryotoxicity of gossypol." Teratology 32, no. 2 (1985): 251–57. http://dx.doi.org/10.1002/tera.1420320213.

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7

de Peyster, Ann, and Yi Y. Wang. "Genetic toxicity studies of gossypol." Mutation Research/Reviews in Genetic Toxicology 297, no. 3 (1993): 293–312. http://dx.doi.org/10.1016/0165-1110(93)90021-e.

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8

Kitada, Shinichi, Lee Jia, Lori C. Coward, et al. "Bcl-2 Antagonist ApoGossypol (NSC736630) Displays Single-Agent Activity in Bcl-2 Transgenic Mice and Has Superior Efficacy and Pharmacology with Less Toxicity Compared to Gossypol (NSC19048)." Blood 108, no. 11 (2006): 2487. http://dx.doi.org/10.1182/blood.v108.11.2487.2487.

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Abstract Altered expression of Bcl-2-family proteins plays a central role in apoptosis dysregulation in cancer and leukemia, promoting malignant cell expansion and contributing to chemoresistance. In this study, we compared the toxicity, pharmacology, and efficacy in mice of Gossypol (NSC19048) and ApoGossypol (NSC736630), a semi-synthetic analog of natural product Gossypol, in which two reactive aldehydes were eliminated from the compound (Becattini, et al Chem & Biol 11(3):389-95, 2004 Mar.). Gossypol and ApoGossypol mimic endogenous BH3 peptide-containing antagonists of anti-apoptotic B

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9

Zaidi, R., and S. M. Hadi. "Interaction of gossypol with DNA." Toxicology in Vitro 6, no. 1 (1992): 71–76. http://dx.doi.org/10.1016/0887-2333(92)90087-8.

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10

Heywood, R., G. K. Lloyd, S. K. Majeed, and C. Gopinath. "The toxicity of gossypol to the male rat." Toxicology 40, no. 3 (1986): 279–84. http://dx.doi.org/10.1016/0300-483x(86)90060-0.

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Dissertations / Theses on the topic "Gossypol – Toxicology"

1

Higgins, C. "Gossypol toxicity and anti-fertility action : Studies of possible mechanisms." Thesis, University of Manchester, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356105.

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Escrivant-Corlay, Catherine. "Toxicologie expérimentale : métabolisme et mode d'action du gossypol." Paris 5, 1989. http://www.theses.fr/1989PA05P130.

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Book chapters on the topic "Gossypol – Toxicology"

1

de Peyster, A. "Gossypol." In Encyclopedia of Toxicology. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-386454-3.00089-0.

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