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HA, Panchal, Basavaraj H, Tiwari R, and Tiwari G. "Evaluating the Efficacy of Gotu Kola (Centella asiatica) Extract in Enhancing Cognitive Function and Reducing Brain Fog in Individuals with Mild Cognitive Impairment." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 1066–70. https://doi.org/10.25258/ijddt.14.4.44.
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Brain fog is a non-medical term that describes a feeling of mental confusion or lack of mental clarity. This research aims to evaluate the efficacy of Gotu Kola (Centella asiatica) extract in managing cognitive function and alleviating brain fog in individuals diagnosed with mild cognitive impairment (MCI). The objective of this study was to find out how well gotu kola (Centella asiatica) extract works at enhancing brain function as well as reducing brain fog. Ethanolic extract of Gotu Kola is obtained from leaves of Centella asiatica.
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Sadik, Fahmi, and A. Rifqah Amalia Anwar. "Standarisasi Parameter Spesifik Ekstrak Etanol Daun Pegagan (Centella asiatica L.) Sebagai Antidiabetes." Journal Syifa Sciences and Clinical Research 4, no. 1 (2022): 1–9. http://dx.doi.org/10.37311/jsscr.v4i1.13310.
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Gotu kola (Centella asiatica L.) is empirically used as a medicinal plant and scientifically it can be used to treat various diseases based on the results of the Scientification of Herbal Medicine. Gotu kola leaf (Centella asiatica L.) is one of the potential medicinal plants that can be used as herbal medicine because it contains various kinds of nutritious compounds. Because of the many benefits of gotu kola leaves, it is necessary to standardize the extract to ensure the quality associated with the identity substance, and the composition of the chemical content whose specifications are stated in the monograph as a quality requirement listed in Materia Medika Indonesia. Standardization includes organoleptic test, identification of chemical content, determination of water soluble extract content, ethanol soluble extract content and other tests, namely seeing the activity of gotu kola as an antidiabetic. The results and data on the characteristics of the specific parameters indicated that the extracts made had met the requirements of the herbal pharmacopoeia, which means that the ethanolic extract of gotu kola had met the standards, and based on activity testing it was known that the leaf of gotu kola (Centella asiatica L.) was efficacious as antidiabetic.
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Ikasari, Endang Diyah, and Tris Harni Pebriani. "REVIEW: A STUDY ON THE USE OF GOTU KOLA EXTRACT (Centella asiatica (L.) Urb.) AS A TREATMENT FOR ACNE." Medical Sains : Jurnal Ilmiah Kefarmasian 9, no. 1 (2024): 1–8. http://dx.doi.org/10.37874/ms.v9i1.1010.
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Acne is an inflammatory skin condition caused by sebaceous follicles and characterized by skin inflammation in the form of a buildup of bacteria and oil that clogs pores and causes acne. Centella asiatica (L.) Urb., often known as gotu kola, has antibacterial properties that inhibit Propionibacterium acnes, thereby reducing papules, pustules, and nodules. Antioxidants, asiatic acid, and madecassic acid found in gotu kola (Centella asiatica (L.) Urb.) can treat wounds. Skin damaged by acne can be repaired and rejuvenated with gotu kola antioxidants, which also help collagen formation more quickly in the skin. This research aims to examine the ability of gotu kola (Centella asiatica (L.) Urb.) extract to inhibit acne-causing bacteria (Propionibacterium acnes) resulting from a literature review. This research method is a literature review or literature review. Research journals that met the inclusion criteria (activity test results suppressing bacterial growth activity) were collected, and a journal summary was made. A summary of the research journals is included in the table sorted by the year of publication of the journal. Based on the results of a literature review carried out by researchers, Gotu kola can be extracted using the maceration method by soaking the plant material in an extraction solvent such as ethanol or water for a specified time. This process was used to remove the active components from the plant material. The inhibition zone formed was evaluated to determine the effectiveness of the extracts or preparations containing gotu kola extract in preventing bacterial growth ...
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Djoko, Wahyuni. "Antioxidant Activity from Combination of Centella asiatica Herb Extract and Moringa oleifera Leaves Extract." FITOFARMAKA: Jurnal Ilmiah Farmasi 12, no. 2 (2022): 144–47. http://dx.doi.org/10.33751/jf.v12i2.5860.
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Antioxidants have an important role in inhibiting free radicals, where free radicals can cause a hereditary disease. Natural medicines that are efficacious as an antioxidant are Gotu kola and kelor leaves. This study aimed to obtain the potential antioxidant compounds in Gotu kola herb extract, kelor leaves extract and the combination using the DPPH method. This research was started by extracting simplicia with 96% ethanol, followed by preparing combination of Gotu kola extract and moringa extract ratio (1:1), (1:2), (1:3), (2:1), (3:1) which was carried out at a concentration of 20, 40, 60, 80, and 100 µl/mL. Furthermore, the antioxidant activity was tested by UV Vis spectrophotometry. Results showed that the IC50 value for the Gotu kola herb extract was 76.66 ± 0.56. Kelor leaves extract 82.66 ± 2.32, a combination of Gotu kola: Moringa (1:1) 74.07 ± 1.16, a combination of Gotu kola: Moringa (1:2) 86.56 ± 1.11, a combination of Gotu kola: Moringa (1:3) 65.09 ± 3.03, a combination of Gotu kola: Moringa (2:1) 56.65 ± 1.61, a combination of Gotu kola: Moringa (3:1) 67.58 ± 2.77. The best potential antioxidant activity was showed in the combination of Gotu kola: Moringa (2:1).
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Purba, Rizky, Made Agus Hendrayana, Ni Nyoman Sri Budayanti, and Ni Nengah Dwi Fatmawati. "Uji aktivitas antibakteri ekstrak etanol daun pegagan (Centella asiatica) terhadap bakteri Streptococcus pneumoniae secara in vitro." Intisari Sains Medis 15, no. 1 (2024): 109–13. http://dx.doi.org/10.15562/ism.v15i1.1943.
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Background: The gotu kola plant (Centella asiatica) is one of the herbal ingredients used throughout the world. This plant contains triterpenoids and saponins which have broad therapeutic functions. Streptococcus pneumoniae has become a global problem that causeing community acquired pneumonia the most in the world. Our study investigate further the antibacterial activity of ethanol extract of Centella asiatica leaves to inhibit Streptococcus pneumoniae bacteria. Methods: The Kirby-Bauer method was used to test the antibacterial activity of gotu kola (Centella asiatica) extract in this study. This is done by measuring the diameter of the inhibition zone and its standard deviation. Results: In the positive control group of Vancomycin 30 µg, the diameter of the inhibition zone was found to be 26.7 mm, 27.15 mm and 28.05 mm. At concentrations of 25%, 50% and 75% of gotu kola leaf (Centella asiatica) ethanol extract, no antibacterial activity was found. Meanwhile, inhibition zone diameters of 8.3 mm, 8.4 mm, and 8.1 mm were found in the ethanol extract of gotu kola leaves (Centella asiatica) with a concentration of 100%. Conclusion: Based on the results obtained, the concentration of 100% ethanol extract of gotu kola leaves (Centella asiatica) has antimicrobial activity but is unable to inhibit the growth of Streptococcus pneumoniae bacteria. Latar Belakang: Tanaman pegagan (Centella asiatica) merupakan salah satu bahan herbal yang digunakan di seluruh dunia. Tanaman ini memiliki kandungan utama triterpenoid dan saponin yang berfungsi sebagai terapeutiknya yang luas. Streptococcus pneumoniae adalah bakteri yang secara historis menjadi patogen paling umum yang menyebabkan pneumonia komunitas di seluruh dunia. Penelitian mengevaluasi lebih lanjut terkait aktivitas antibakteri ekstrak etanol daun pegagan terhadap bakteri Streptococcus pneumoniae. Metode: Metode Kirby-Bauer digunakan untuk pengujian aktivitas antibakteri ekstrak pegagan (Centella asiatica) pada penelitian ini. Hal ini dilakukan dengan mengukur diameter zona hambat dan standar deviasinya. Hasil: Pada kelompok kontrol positif Vancomycin 30 µg, ditemukan diameter zona hambat sebesar 26,7 mm, 27,15 mm, dan 28,05 mm. Pada konsentrasi ekstrak etanol daun pegagan 25%, 50%, dan 75% tidak ditemukan aktivitas antibakteri. Sedangkan, diameter zona hambat sebesar 8,3 mm, 8,4 mm, dan 8,1 mm ditemukan pada ekstrak etanol daun pegagan (Centella asiatica) konsentrasi 100%. Kesimpulan: Penelitian ini menunjukkan bahwa konsentrasi ekstrak etanol daun pegagan (Centella asiatica) 100% mampu menunjukan aktivitas antimikroba tetapi tidak dapat menghambat pertumbuhan bakteri Streptococcus pneumoniae.
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Komaliya, Risyda, and Mia Audina. "UJI IRITASI SEDIAAN STICK TABIR SURYA EKSTRAK BUNGA TELANG (Clitoria ternatea (L.)) DAN PEGAGAN (Centella asiatica (L.))." BUANA SAINS 24, no. 3 (2024): 93–96. https://doi.org/10.33366/bs.v24i3.6002.
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Butterfly pea flowers (Clitoria ternatea (L.)) and gotu kola (Centella asiatica (L.)) contain phenolic compounds. The phenolic compounds in butterfly pea flowers are anthocyanins, while in gotu kola, there are flavonoids and tannins. Butterfly flower extract and gotu kola extract have certain concentrations of SPF values in the maximum category. This research aimed to determine the results of the irritation test of sunscreen stick preparations of butterfly pea flower extract (Clitoria ternatea (L.)) and gotu kola (Centella Asiatica (L.)). This research uses an experimental approach with a true experimental design. Stick preparations are divided into formulations with a combination of active ingredients of butterfly pea flower (Clitoria ternatea (L.)) at a concentration of 2% or 3%, and gotu kola extract (Centella asiatica (L.)) at a concentration of 7% or 8%. The optimal formulation of the preparation is adjusted to the evaluation results and specified requirements. The research showed that sunscreen sticks with two different formulations were applied to the skin 2.5 cm wide and then left for 1 hour to determine whether the skin began to show signs of irritation, such as redness, swelling, or itching. This irritation test was carried out on 20 volunteers, then observed for 3 days, and showed that the formulation of 2 sunscreen stick preparations did not irritate
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Yahya, Muhammad Ainul, and Iif Hanifa Nurrosyidah. "Antioxidant activity ethanol extract of gotu kola (Centella asiatica (L.) Urban) with DPPH method (2,2-Diphenyl-1-Pikrilhidrazil)." Journal of Halal Product and Research 3, no. 2 (2020): 106. http://dx.doi.org/10.20473/jhpr.vol.3-issue.2.106-112.
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Unhealthy lifestyles and air pollution cause the number of free radicals in the body to increase. To protect the body from free radicals, there are antioxidant compounds as an antidote and stabilize free radicals. One of the Indonesian plants that can be used as antioxidants is gotu kola (Centella asiatica (L.) Urban. Objective: This study aims to determine the antioxidant activity of the ethanol extract of gotu kola herb using the DPPH (2,2-Diphenyl-1-pikrilhidrazil) method. with IC50 value. Method: Gotu kola (Centella asiatica (L.) Urban) was extracted by the soxhletation method using 96% ethanol solvent. The testing of antioxidant activity was carried out using the DPPH (2.2 Diphenyl-1-Pikrihydrazil) method. Result: Test results of antioxidant activity The ethanol extract of gotu kola herb showed an IC50 value of 78.20 ppm. Conclusion: This indicated that the ethanol extract of gotu kola herb was included in the criteria for strong antioxidants.
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Harahap, Susilawati. "Bioactive Compound Analysis and Antioxidant Activity Test on Ethanol Extract of Gotu Kola Leaves (Centella Asiatica) with Different Solvent Concentrations." Formosa Journal of Science and Technology 3, no. 2 (2024): 307–22. http://dx.doi.org/10.55927/fjst.v3i2.8166.
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Gotu kola (Centella Asiatica) contains the active ingredients alkaloids, saponins, tannins, flavonoids, steroids and triterpenoids. Three bioactive groups, namely triterpenoids, steroids and saponins, are antioxidants that are beneficial for the health of the human body. The aim of this research is to identify the phytochemical content, total flavonoid content and antioxidant activity in gotu kola (Centella Asiatica) leaves with different solvent concentrations. The type of research is Qualitative and Quantitative with an Experimental laboratory research design carried out at the Itkessu Pharmaceutical Laboratory. The results of the phytochemical screening identified that pegagan (Centella Asiatica) leaves were positive for containing alkaloids, flavonoids, steroids, triterpenoids and saponins at both solvent concentrations. The UV-Vis results showed that the total flavonoid content in gotu kola (Centella Asiatica) leaves was 31.6271 mg QE/Gr for 70% ethanol and 21.7821 mg QE/Gr for 96% ethanol, while the IC50 value was 53.2210 ppm for 70% ethanol and 61.7269 ppm for 96% ethanol.
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Tulung, Grace Laury, Widdhi Bodhi, and Jainer Pasca Siampa. "UJI EFEKTIVITAS EKSTRAK ETANOL DAUN PEGAGAN (Centella asiatica (L.) Urban) SEBAGAI ANTIDIABETES TERHADAP TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI ALOKSAN." PHARMACON 10, no. 1 (2021): 736. http://dx.doi.org/10.35799/pha.10.2021.32767.
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ABSTRACT Gotu Kola Leaf (Centella asiatica (L.) Urban) are known to contain flavonoid compound, and flavonoid are known to decrease blood glucose level by stimulating pancreas beta cells to produce insulin. The aim of this research is to find out wether the ethanol extract of gotu kola leaf (Centella asiatica (L.) Urban) has the antidiabetic effectiveness or not. This research used Completely Randomized Design method. There were 15 rats used in this research that were split into 5 groups that is negative control (Aquadest), positive control (Metformin), and ethanol extract of gotu kola leaf with the dosage of 5.4 mg;10.8 mg;21.6 mg. The acquired data were analyzed with ANOVA test and LSD test. The analysis result showed that ethanol extract of gotu kola leaf had antidiabetic effectiveness against male white rat. Keywords: Centella asiatica (L.) Urban, antidiabetic, Rattus norvegicus ABSTRAK Daun Pegagan (Centella asiatica (L.) Urban) diketahui mengandung zat flavonoid, dimana flavonoid telah diketahui mempunyai kemampuan menurunkan kadar glukosa darah dengan merangsang sel beta pankreas untuk memproduksi insulin. Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol daun pegagan memiliki efekivitas antidiabetes. Penelitian ini menggunakan metode Rancangan Acak Lengkap. Tikus yang digunakan sebanyak 15 ekor dan dibagi dalam 5 kelompok yaitu kontrol negatif (aquadest), kontrol positif (metformin), dan ekstrak etanol daun pegagan dengan dosis 5,4 mg; 10,8 mg; 21,6 mg. Data yang ada dianalisis dengan menggunakan uji ANOVA dan uji LSD. Hasil analisis menujukkan bahwa ekstrak etanol daun pegagan memiliki efektivitas antidiabetes terhadap tikus putih jantan (Rattus norvegicus). Kata kunci: Centella asiatica (L.) Urban, antidiabetes, Rattus norvegicus
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Nurrosyidah, Iif Hanifa. "Aktivitas Antioksidan Ekstrak Etanol Herba Pegagan (Centella asiatica (L.) Urban) Dengan Metode DPPH (2,2-Difenil-1-Pikrilhidrazil)." Journal of Pharmaceutical Care Anwar Medika 3, no. 1 (2020): 46–54. http://dx.doi.org/10.36932/jpcam.v3i1.44.
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Unhealthy lifestyles and air pollution cause the number of free radicals in the body to increase. To protect the body from free radicals, there are antioxidant compounds as an antidote and stabilize free radicals. One of the Indonesian plants that can be used as antioxidants is gotu kola (Centella asiatica (L.) Urban. This study aims to determine the antioxidant activity from hand and body lotion extract of gotu kola by DPPH (2,2-Diphenyl-1-Picrylhydrazyl) method which is expressed as an IC50 value. Gotu Kola (Centella asiatica (L.) Urban) was extracted by the soxhletation method using a solvent etanol 96% and formulated in the from of hand and body lotion using variations of gotu kola extract concentrations of 1%, 3% and 5%. Then do a physical evaluation of three preparations of hand and body lotion to determine the best formula to be tested for antioxidant activity. Hand and body lotion preparation formula with as much gotu kola extract concentration 5% shows the best formula. The results of testing antioxidant activity on hand and body lotion showed IC50 value of 449.14 ppm. This indicates that the Antioxidant activity of gotu kola extract hand and body lotion is included in the very weak antioxidant criteria.
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Nurrosyidah, Iif Hanifa. "Aktivitas Antioksidan Ekstrak Etanol Herba Pegagan (Centella asiatica (L.) Urban) Dengan Metode DPPH (2,2-Difenil-1-Pikrilhidrazil)." Journal of Pharmaceutical Care Anwar Medika 3, no. 1 (2020): 46–54. http://dx.doi.org/10.36932/jpcam.v3i1.44.
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Unhealthy lifestyles and air pollution cause the number of free radicals in the body to increase. To protect the body from free radicals, there are antioxidant compounds as an antidote and stabilize free radicals. One of the Indonesian plants that can be used as antioxidants is gotu kola (Centella asiatica (L.) Urban. This study aims to determine the antioxidant activity from hand and body lotion extract of gotu kola by DPPH (2,2-Diphenyl-1-Picrylhydrazyl) method which is expressed as an IC50 value. Gotu Kola (Centella asiatica (L.) Urban) was extracted by the soxhletation method using a solvent etanol 96% and formulated in the from of hand and body lotion using variations of gotu kola extract concentrations of 1%, 3% and 5%. Then do a physical evaluation of three preparations of hand and body lotion to determine the best formula to be tested for antioxidant activity. Hand and body lotion preparation formula with as much gotu kola extract concentration 5% shows the best formula. The results of testing antioxidant activity on hand and body lotion showed IC50 value of 449.14 ppm. This indicates that the Antioxidant activity of gotu kola extract hand and body lotion is included in the very weak antioxidant criteria.
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Purnamasari M, Vina, Nurlina Nurlina, and Anita Sari Anwar. "Formulasi dan Evaluasi Masker Hyrogel Ekstrak Etanol Pegagan (Centella Asiatica (L). Urb) Sebagai Antiaging dengan Variasi Basis Carbopol dan HPMC." Journal of Pharmaceutical and Health Research 4, no. 2 (2023): 285–96. http://dx.doi.org/10.47065/jharma.v4i2.3644.
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Gotu kola ethanol extract (Centella asiaticaI (L)urb.) has very strong antioxidant activity with an IC50 value of 20.43 μg/ml which can be utilized in the development of pharmaceutical or cosmetic preparations. The purpose of this study was to formulate and evaluate a pharmacologically stable preparation of hydrogel antiaging mask of gotu kola ethanol extract (Centella asiaticaI (L)urb.). The research design used by varying the concentration of carbopol and HPMC was then carried out physical evaluations such as organoleptis, homogeneity, ph measurement, viscosity and flow type tests, adhesion tests, dispersion tests, weight and size tests of hydrogel masks, inflating power tests and shrinkage tests and stability tests. The evaluation results showed that gotu kola ethanol extract (Centella asiaticaI (L)urb.) that met the pharmaceutical stability test was formula 2 with a carbopol concentration of 1.25% and HPMC 2.25%.
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Kusumaningrum, Intan, Distya Riski Hapsari, Arti Hastuti, and Lia Amelia. "Penambahan Ekstrak Daun Pegagan (Centella Asiatica) Terhadap Mutu Kimia Susu Pasteurisasi Selama Penyimpanan Suhu Dingin." JURNAL AGROINDUSTRI HALAL 11, no. 1 (2025): 134–41. https://doi.org/10.30997/jah.v11i1.10054.
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Pasteurized milk with the addition of gotu kola leaf extract has higher total phenols and antioxidant activity than pasteurized milk alone. Therefore, pasteurized milk with the addition of extracts has the potential to improve its storage quality. This experiment aimed to study the quality of pasteurized milk with the addition of gotu kola extract, which was stored at 5°C for nine days. This research consists of factor A, namely the addition of gotu kola leaf extract with four different treatment levels (A1 = 0%, A2 = 0.25%, A3 = 0.50%, A4 = 0.75%) and Factor B, namely storage time, between 0 and 9 days with an interval of 3 days (0, 3, 6, and 9 days). The research results showed that the greater the addition of gotu kola leaf extract and the longer the storage time, the lower the pH value and protein content, increase the total acid, and a positive alcohol test. Adding gotu kola leaf extract to milk reduces the storage period by up to three days, compared to the storage period of up to six days for pasteurized milk without extract.
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Damayanti, Ida Ayu Manik, Ni Wayan Sukma Antari, and Sri Dewi Megayanti. "Antioxidant potential of gotu kola leaf extract (Centella asiatica (L.) Urban) as an alternative to antihyperglycemic herbal drinks." Jurnal Pijar Mipa 17, no. 6 (2022): 782–86. http://dx.doi.org/10.29303/jpm.v17i6.4179.
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This study aims to determine the antihyperglycemic potential of Gotu kola leaf extract (Centella asiatica (L.) Urban as an alternative herbal drink in diabetic male white mice. This study was divided into four stages: extracting Gotu kola leaves using 96% ethanol as solvent, phytochemical screening, and testing antihyperglycemic activity. Male white mice were made diabetic by alloxan-induced. Mice were divided into five groups consisting of negative control (Aquadest), positive control (Glibenclamide 13 mg/Kg BW), dose 1 (200 mg Gotu kola extract/kg BW), dose 2 (400 mg Gotu kola extract/kg BW), dose 2 (400 mg Gotu kola extract/kg BW), 3 (600 mg Gotu kola extract/kg BW). The results of phytochemical screening showed that the Gotu kola leaf extract was positive for flavonoids and tannins. The analysis results on the Gotu kola leaf extract showed an IC50 value of 80.58 ppm, including strong antioxidant activity. The results of the antihyperglycemic activity test showed that diabetic male white mice were found to have decreased blood sugar levels on days 14 and 21 by respectively 24.3% and 41.6%; 25.4% and 42.3%; 37.8% and 55.3% after administration of Gotu kola leaf extract at P1, P2, and P3.
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Hapsari, Distya Riski, Intan Kusumaningrum, Arti Hastuti, Caesandra Indah Arlina, and Lia Amelia. "Total Phenolic Content and Antioxidant Activity of Pasteurized Milk With the Addition of Centella asiatica Leaf Extract." JURNAL AGROINDUSTRI HALAL 9, no. 3 (2023): 312–19. http://dx.doi.org/10.30997/jah.v9i3.7433.
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Milk has a high nutritional value. Minimal processing that can extend the shelf life of milk is pasteurization, but it can damage the nutritional content of milk. One of the additional efforts to improve milk quality and maintain the nutritional content of milk is to provide additional active compounds that act as antioxidants for milk consumers and the milk product itself. The use of Centella asiatica leaf extract as an ingredient is because there are at least 139 active compounds. This study aimed to study the total phenolic content and antioxidant activity of pasteurized milk with the addition of Centella asiatica leaf extract. The research was carried out in two stages, namely making gotu kola leaf extract and making pasteurized milk by adding gotu kola leaf extract concentrations of 0%, 0.25%, 0.5%, and 0.75%. Product analysis included total phenol analysis using Folin Ciocalteau and antioxidant activity using the DPPH method. Adding Centella asiatica leaf extract can increase total phenolic content and antioxidant activity. The total phenolic content obtained by adding Centella asiatica leaf extract at 0%, 0.25%, 0.50%, and 0.75% were 0.58 mgGAE/g, 1.93 mgGAE/g, respectively 2.33 mgGAE/g, and 3.41 mgGAE/g. At the same time, the results of antioxidant activity were 7.68%, 31.93%, 37.57, and 40.35%, respectively.
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Setyoningsih, Dwi, Shelly Taurhesia, and Teti Indrawati. "PENGEMBANGAN PENYUBUR RAMBUT MENGGUNAKAN KOMBINASI EKSTRAK ETANOL HERBA PEGAGAN (Centella Asiatica (L) Urban) DAN EKSTRAK N-HEKSANA BAWANG PUTIH (Allium Sativum L)." Jurnal Ilmiah Manuntung 7, no. 2 (2021): 208–14. http://dx.doi.org/10.51352/jim.v7i2.495.
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Centella asiatica contains asiaticoside, flavonoid, phytosterol, madecassid acid, madecassoside, Asiatic acid and amino acid which are potentially stimulating hair growth, while Allium sativum has rich nutrient for hair growth such as alkaloid and sterol/terpenoid. Objective: previous study showed each extract has activity to stimulate hair growth but there was no study yet for a combination of these two extracts. The objective of this study was to find right concentration for combination of gotu kola herb extract and garlic extract which can stimulate hair growth, and the best combination will be then formulated into hair tonic and test its activity. Methods: Application on 3 male rabbits for 28 days of combination of 1.25% gotu kola herb extract and 100 ppm garlic extract showed hair growth of 34.10 mm, hair growth acceleration 1.388 mm /day and hair weight 27.816 mg. Then Hair tonic was developed using three different formulas, namely F1 contains of 2.5% gotu kola herb extract and 0.02% garlic extract; F2 contains of 2,5% gotu kola herb extract and 0.04% garlic extract and F3 contains of gotu kola herb extract 5% and garlic extract 0.04%. This hair tonic has green color, distinctive odor, homogeneity, a viscosity of 2.629 cP to distilled water, and pH 5.6. The results showed that Hair tonic of F3 with a concentration of 5% gotu kola herb extract and 0,04% garlic extract gave hair growth of 28,62 mm, rate of hair growth of 1,057 mm/day and hair weight of 28,84 mg, and this hair tonic is stable for 3 months storage at 25oC as well as at 40oC.
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Nurlatifah, Nurlatifah, Lidyawati Lidyawati, Rosa Mardiana, Dwi Putri Rejeki, and Mona Asiah. "Formulasi Sediaan Gel Dari Ekstrak Etanol Herba Pegagan (Centella asiatica (L) Urb)." Journal of Pharmaceutical and Health Research 3, no. 1 (2022): 10–14. http://dx.doi.org/10.47065/jharma.v3i1.1366.
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Indonesia is a rich country in terms of flora and fauna diversity. Indonesia's wealth with various types of flora is a highlight for science, one of which is the gotu kola herb (Centella asiatica (L) Urb). The chemical compound asiaticoside is part of the triperoids contained in the gotu kola herb which has the potential as antibacterial, antifungal, antioxidant and anti-cellulite on the skin, suitable for topical preparations such as gels. This study aims to formulate a gel preparation from the ethanolic extract of the gotu kola herb (Centella asiatica (L) Urb) which meets the requirements of a good gel. The formulation of the gel preparation was carried out with concentrations of 20%, 25%, and 30%. Extracted by maceration method using 70% ethanol and in a vacuum rotary evaporator to obtain a thick extract. Evaluation of the gel preparation was carried out by organoleptic test, homogeneity test, pH test, dispersibility test, adhesion test and irritation test. The results of the evaluation carried out with the three concentrations met the requirements of the organoleptic test, homogeneity test, pH test, adhesion test and irritation test, but the ethanol extract gel of the gotu kola herb at concentrations of 20%, 25% and 30% did not meet the requirements for the good dispersion test
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Wulansari, Nadya Treesna, A. A. Istri Mas Padmiswari, and Kadek Buja Harditya. "Antimicrobial Activity of Gotu Kola (Centella asiatica) Leaf Extract as an Alternative to Herbal Beverage." Jurnal Biologi Tropis 23, no. 2 (2023): 319–25. http://dx.doi.org/10.29303/jbt.v23i2.4817.
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Pathogenic microorganisms include Aspergillus sp., Escherichia coli and Staphylococcus aureus. Antibiotic administration during the treatment of contagious illnesses may cause bacterial resistance. Treatment with herbal medicine, made from natural ingredients, is an option to prepare for this. A plant known as gotu kola (Centella asiatica) has the capacity to become a herbal beverage. The intention of this research was to discover whether gotu kola leaves, a herbal beverage, had any antimicrobial properties. This study was categorized as an experimental study with an entirely random approach. This study performing an analysis of variance on the data, the Duncan's Multiple Range Test was conducted. The findings demonstrated that Staphylococcus aureus and Escherichia coli bacteria could not grow when exposed to gotu kola leaf extract. Gotu kola leaf preparation has the ability to stop Staphylococcus aureus and Escherichia coli from growing. The greatest average hindrance of 9.67 ± 0.36 mm and 10.12 ± 1.12 mm against Escherichia coli and Staphylococcus aureus bacteria was obtained by 100% concentrated infusion from the leaves of gotu kola. Alkaloids, flavonoids, and tannins are examples of the gotu kola leaf extract's metabolite components that can increase the inhibitory power of the herb. However, the Aspergillus sp. in this research was not inhibited by the gotu kola extract. The body structure of the Aspergillus sp. and length of storing of the gotu kola extract are probable causes for there was not inhibitory effect.
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Harsa, I. Made Subhawa. "Efek Pemberian Ekstrak Daun Pegagan (Centella Asiatica) Terhadap Penyembuhan Luka Sayat Pada Tikus Putih Jantan (Rattus Norvegicus) Galur Wistar." Jurnal Ilmiah Kedokteran Wijaya Kusuma 9, no. 1 (2020): 21. http://dx.doi.org/10.30742/jikw.v9i1.664.
Full textAbstract:
Wound refers to partly damage or loss of body tissue. One way that has been used by the people in helping the process of wound healing is the use of medicinal plants, such as gotu kola (Centella asiatica). Gotu kola (Centella asiatica) is kind of plant that found almost in all territories of Indonesia which functions as a cell revitalizing substance which quickens wound healing those are burnt, skin ulcer and to prevent keloid. This study is aimed to know the effect of giving gotu kola leaf extract (Centella Asiatica) against to the healing of the wound incision on male white rats (Rattus Norvegicus) wistar strain. This study is a pure experimental research using the randomized post test only control group design with the subjects are 30 male white rats (Rattus norvegicus) wistar strain that were divided into 3 groups, namely K1, K2, and K3. The incision wound were made on the back of all white rat in each group with a length of ± 2 cm and a depth of ± 2 mm. The wound in the negative control group (K1) was not given any substance; in the positive control group (K2) was given povidone iodine 10%; and in the treatment group (K3) was given gotu kola leaf extract at a dose of 37,5 mg/150 grBB. The study was done for 10 days. Furthermore, wound observation and monitoring is held. Then the results were processed by using One Way ANOVA. The result study of wound incision healing on male white rats (Rattus norvegicus) wistar strain shows that there is significant difference among the negative control group (K1), the positive control group (K2), and the treatment group (K3) on One Way ANOVA test which significant p-value are 0,027 (p < 0.05). The result of Post-Hoc LSD test also shows a significant differences among the K1 and K3 groups, and K2 and K3 groups which significant p-values are 0,011 and 0,038 (p < 0,05). From these results, it can be concluded that gotu kola leaf extract (Centella asiatica) effective on quickens wound healing of the wound incision on male white rats (Rattus norvegicus) wistar strain.
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Vinolina, Noverita Sprinse, and Riswanti Sigalingging. "Growth and Secondary Metabolites Production of Centella asiatica (L.) Urb. Cultivated at Different Phosphate Application Rates in Acid Soil." Trends in Sciences 19, no. 18 (2022): 5820. http://dx.doi.org/10.48048/tis.2022.5820.
Full textAbstract:
Centella asiatica (L.) Urb. is a widely known medicinal plant for dermatological and non-dermatological diseases. The demand for C. asiatica extracts continues to increase but its availability is markedly depleted due to exploitation and limited cultivation. This study was conducted to evaluate the phosphate growth responses and variation of secondary metabolites production of C. asiatica cultivated at different phosphate application rates in acid soil in Indonesia. The soil pH used in this study was 2.76. Rates of phosphate application were 0 kg per plant as control plant, 20, 40, 60, 80 and 100 kg ha-1, respectively. Results showed that the plants applied with 40 kg ha-1 phosphate resulted in the highest number of leaves, petiole length, total leaf area, and number of tendrils and stolons which lead to the higher biomass. C. asiatica produced various types of secondary metabolites, i.e asiaticoside, madecassoside, asiatic acid, saponin, tannin, phenolic, flavonoid, triterpenoid, steroid, and glycoside. The production of secondary metabolites was optimized by the application of 20 kg ha-1 phosphate. It can be concluded that the application low dosage of phosphate can enhance the growth and secondary metabolites production of C. asiatica cultivated in acid soil.
 HIGHLIGHTS
 
 Gotu kola is well-known medicinal plant that has which has been used for generations and its benefits has been confrmed by the consumers
 Gotu kola can grow in both lowlands and highlands but the centellosides contents in gotu kola affected by the growing medium and phosphorus application
 The demand for simplicia is increasing, while the availability of gotu kola is limited in nature may cause gotu kola become rare and even endangered. Thus, it is necessary to cultivate gotu kola to maintain good quality and quantity
 The specific target to be achieved is the availability of gotu kola with optimal centelloside content
 
 GRAPHICAL ABSTRACT
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HAYANTI, IRMA PUTRI, RETNA BANDRIYATI AMIPUTRI, and PRASWANTO PRASWANTO. "The effect of liquid organic fertilizer and pearl grass extract on shoot growth of gotu kola (Centella asiatica) in vitro." Biofarmasi Journal of Natural Product Biochemistry 10, no. 2 (2012): 54–60. http://dx.doi.org/10.13057/biofar/f100204.
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Hayanti IP, Amiputri RB, Praswanto. 2012. The effect of liquid organic fertilizer and pearl grass extract on shoot growth of gotu kola (Centella asiatica) in vitro. Biofarmasi 10: 54-60. Gotu kola (Centella asiatica L.) is a medicinal crop, needed by local industry of pharmacy. Gotu kola in Indonesia is not enough to supply in market requisites. Tissue culture method was used to multiply gotu kola with a combination of medium from liquid organic fertilizer and pearl grass extract. The purposes of the research were to determine the effect of liquid organic fertilizer and pearl grass extract on the shoot growth of gotu kola in vitro, and to obtain the optimal concentration of liquid organic fertilizer and pearl grass extract combination on the shoot formation of gotu kola in vitro. The research was conducted in November 2010 to June 2011 in Plant Physiology and Biotechnology Laboratory, Faculty of Agriculture, Sebelas Maret University, Surakarta. The experimental design used was a Completely Randomized Design (CRD) with two treatment factors and three replications. The first factor was liquid organic fertilizer concentrations, i.e. 0 mL/L, 2 mL/L, 4 mL/L and 8 mL/L. The second factor was pearl grass extract, i.e. 0 mL/L, 3 mL/L, 6 mL/L and 12 mL/L. Variables observed were the percentage of shoot formation, the time of shoot formation, the number of shoot, the length of shoot, the percentage of leaf formation, the time of leaf formation and the number of leaf. The result of the research showed that not all of treatments provided shoot formation. The combination of liquid organic fertilizer concentrations 0 mL/L and pearl grass extract 12 mL/L showed the best results, in which the average of length of shoot was 2.16 cm, the number of shoot was 8 and the number of leaf was 8.
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Dewi, I. Dewa Ayu Sudiari, Nurmawati Fatimah, and Sutji Kuswarini. "Effect of Topical Gel Ethanol Extract of Gotu Kola Leaf (Centella Asiatica (L.) Urban) on Wound Healing in a White Male Rat (Rattus Norvegicus) Induced by Streptozotocin." Surabaya Physical Medicine and Rehabilitation Journal 5, no. 2 (2023): 78–83. http://dx.doi.org/10.20473/spmrj.v5i2.47921.
Full textAbstract:
Background: Diabetes mellitus (DM) can have a number of consequences, one of which is diabetic neuropathy, which can cause sores, notably in patients' feet. Wound therapy with synthetic drugs in diabetes is still not functioning as well as expected. Centella Asiatica (L.) Urban has been demonstrated to promote wound healing through a variety of mechanisms, including collagen synthesis stimulation, fibroblast proliferation stimulation, antiulcer, antibacterial, and antioxidant activity. Pharmaceutical treatments for wound healing are routinely utilized upon the assumption that a moist wound is a gel. Aims: The purpose of this study was to see how a topical gel ethanol extract of gotu kola (Centella Asiatica (L.) Urban) promoted wound healing in streptozotocin (STZ)-induced white male rats (Rattus Norvegicus). Methods: This is an experimental study using twenty white male rats (Rattus Norvegicus) caused by STZ. The rats were placed into four groups, each with five rats. These four groups are the control group, the treatment group P1 (ethanol gel gotu kola leaf at 2.5% concentration), the treatment group P2 (ethanol gel gotu kola leaf at 5% concentration), and the treatment group P3 (ethanol gel gotu kola leaf at 10% concentration). STZ was used to promote blood sugar elevation in the rats. The wound healing rate was estimated by comparing the wound healing rates of each group using macroscopic observation. Result: The findings of this study revealed that extract gel gotu kola leaf concentration applied to the wound on days 4, 7, 11, and 14 has a statistically significant influence on wound healing (p=0.000). Conclusion: Based on the research conducted, it can be concluded that gotu kola extract gel has a significant influence on the rats’ wound healing.
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Shanastasia, Swastila. "REVIEW OF PHYTOSOME POTENTIAL OF GOTU KOLA (CENTELLA ASIATICA) EXTRACT TO RESTORE NERVE CELL MEMBRANE AND IMPROVE COGNITIVE FUNCTION." International Journal of Advanced Research in Engineering and Technology (IJARET) 11, no. 5 (2020): 1–6. https://doi.org/10.34218/IJARET.11.5.2020.001.
Full textAbstract:
One of the herbs in Indonesia, Gotu Kola (Centella asiatica) contains triterpenoid glycosides, which are ethnomedicine used as neuroprotectors. Phytochemical components of Gotu Kola extract tend to be polar, so it needs an approach to modify the polarity of the extract. The method is to formulate an extract in the form of phytosome as an herbal delivery system so that it can increase the absorption and bioavailability of the active substance. It is suitable for the delivery system of active compounds from plants because it can carry hydrophilic and lipophilic compounds from plants. This paper specifically reviews the potential of the plant extracts for the recovery of nerve cell membranes and improving one's cognitive function.
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Indria, Indria, and Asti Rahayu. "Effectiveness of Gotu Kola Extract Lotion (Centella Asiatica) in Reducing Stretch Marks." Journal of Health Sciences 14, no. 3 (2021): 196–201. http://dx.doi.org/10.33086/jhs.v14i3.2066.
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Stretch marks result from mechanical factors, namely stretching of the skin due to the development of subcutaneous structures (interstitial adipose tissue) or biochemical factors (the presence of excessive glucocorticoids that inhibit fibroblast activity and proliferation). There is no truly effective treatment for removing striae once they have formed. This study evaluates the effectiveness of administering Gotu Kola Extract (Centella asiatica) on the stretch mark. This paper was a Quasi-Experimental study with a pretest-posttest design. This study was conducted at the Independent Practice Midwife (IMP) Zummatul Atika in October-December 2020. The population was postpartum mothers (days 0-6) with stretch marks. Meanwhile, there were 12 respondents by purposive sampling technique. The independent variable was Gotu kola extract lotion, while the dependent variable was stretch marks with ratio data. Collecting data with a structured interview to gather the characteristics of respondents and participant observation to evaluate changes (number of stretch marks, color, moisture, and skin condition) in stretch marks before and after intervention during one month. The Gotu kola extract lotion was made in the pharmacy laboratory of PGRI Adi Buana University Surabaya within several stages. The data analysis used the paired T-test, and the result showed p= 0.000, indicating a significant difference before and after the intervention. This study concludes that administering Gotu Kola Extract (Centella asiatica) lotion effectively reduces skin pigmentation and lines in stretch marks, increases skin moisture, and refines skin texture.
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Marini, Marini, Nur Azizah, Devin Nur Rohman, and Angga Anugra Diputra. "EFFECTIVENESS TEST OF WOUND PATCH PREPARATIONS OF GOTU KOLA LEAF EXTRACT (Centella asiatica (L.) Urb.) ON INCISION WOUND IN RABBITS." Medical Sains : Jurnal Ilmiah Kefarmasian 8, no. 4 (2023): 1525–36. http://dx.doi.org/10.37874/ms.v8i4.923.
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A wound patch is a dosage form that delivers drugs through the skin to produce systemic effects, with the advantage of controlled drug release. Centella asiatica (L.) Urb.) is widely used to heal incision wounds on the skin. The most important component was asiaticoside, which plays a major role in accelerating wound healing. This study was conducted to test the effectiveness of transdermal patches from Centella asiatica (L.) Urb.) against incision wounds was performed on 5 rabbits divided into different treatment groups, namely group I without treatment, group II wound patch base (negative control), group III plaster (positive control), and groups IV and V, comprising a wound patch of gotu kola leaf extract at concentrations of 16% and 32%, respectively. The data obtained were statistically tested for normality using the Shapiro-Wilk test. The results showed that the wound patch preparation of 16% gotu kola leaf extract showed a significant difference (p < 0.05) in wound length reduction compared to the negative and normal controls. The wound healing time observed at concentrations of 16% and 32% provided wound healing effects. The best effect was observed at a concentration of 16%, with an average wound closure time of 12 days. It can be concluded that gotu kola leaf extract in the form of a wound patch preparation was effective in wound healing. Keywords: Gotu kola leaf extract; incision wound; Wound patch; Effectiveness test
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Sari, Diah Puspita, Shintya Yuniar, Siti Awalia Nur Fadillah, Afifi Mutiarani, and Diah Kusumawaty. "The Effectiveness of Mugwort Leaf Extract and Gotu Kola Leaf Extract against Acne Bacterial Activity." ASEAN Journal of Science and Engineering 2, no. 3 (2022): 249–56. http://dx.doi.org/10.17509/ajse.v2i3.39634.
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Acne is a problem among teenagers generally caused by bacterial infections such as Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. Mugwort (Artemisia vulgaris L.) and Gotu Kola (Centella asiatica L.) extracts have antibacterial activity formulated in anti-acne gel preparations. The purpose of this study was to test and obtain a gel formula of mugwort leaf extract and gotu kola leaf extract which effectively kills and controls the growth of acne-causing bacteria. The methods used in this study include simplicity making, leaf extraction, making anti-acne gel preparations, testing pH, homogeneity, inhibition, and data analysis. The extract obtained by maceration was made in three concentrations, namely 2.50; 5.00; and 10.00%. The results showed that the pH value of the gel preparations obtained was in the range of 8.08-9.96. Mugwort leaf extract, gotu kola leaf, and mugwort-gotu kola have a distinctive smells with a thick texture at a concentration of 2.50% and a liquid texture at a concentration of 10.00%. Inhibition tests showed that the mugwort extract sample had a value of 16-18 mm, while the gotu kola extract and mugwort-gotu kola had a value of 14 mm. Mugwort leaf extract is able to inhibit the growth of acne-causing bacteria. This success was obtained because the extracts of mugwort and gotu kola leaves contain flavonoids that can inhibit the growth of bacteria that cause acne. Mugwort leaf extract gel with a concentration of 2.50 and 5.00% had the largest zone of inhibition in inhibiting P. acnes bacteria compared to other concentrations.
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Swintari, Ni Wayan, Yuliet Yuliet, and Khilda Khaerati. "Aktivitas Kombinasi Ekstrak Etanol Daun Sirsak (Annona muricata L.) Dan Daun Pegagan (Centella asiatica L.Urb) Terhadap Kelarutan Kalsium Batu Ginjal Secara In Vitro." Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) 3, no. 1 (2017): 34–42. http://dx.doi.org/10.22487/j24428744.2017.v3.i1.8137.
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Soursop (Annona muricata L.) and gotu kola (Centella asiatica L.Urb) is a plant that can be used as a laxative medicine kidney stones. This is because of the content of bioactive compounds including flavonoids, especially the leaf section. The use of a combination of soursop leaf extract and gotu kola can improve their effectiveness in order to remove calcium kidney stones. Therefore, this study aims to determine the activity and to determine dose combination soursop leaf ethanol extract (SS) and gotu kola leaf (GK) which is effective for dissolving potassium kidney stones. Extracts prepared by maceration method using ethanol 96% then subsequently tested phytochemical screening and thin layer chromatography profiles on each extract. Results chromatogram showed the extract containing flavonoids. Testing the activity of the combination of soursop and gotu kola extract performed using seven treatments, combination 1 (SS 1% + GK 7.5% ), a combination of 2 (SS 0.5% + GK 3.75%), the combination of 3 (SS 0, 25% + GK 1.875%), single soursop leaf extract (1%), single gotu kola extract (7.5%), negative control (aquadest) and positive control (Batugin elixir). Kidney stones are then put as much as 100 mg in each treatment and incubated for 6 hours (37 ℃). Results filtrate then didestruksi and dissolved calcium levels measured using Atomic Absorption Spectrophotometer. The results showed the combination soursop leaf ethanol extract and gotu kola leaf extract with a combination of 2 (SS 0.5% + GK 3.75%) is an effective combination of the ability to dissolve calcium kidney stones in vitro.
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Sigiro, Stareast Wulandari, Ni Luh Arpiwi, and Ni Made Susun Parwanayoni. "Formulasi Body Mask dari Daun Pegagan (Centella asiatica L.) untuk Perawatan Kulit." Metamorfosa: Journal of Biological Sciences 10, no. 1 (2023): 143. http://dx.doi.org/10.24843/metamorfosa.2023.v10.i01.p15.
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Body mask is one of the cosmetic preparations used in the last process in skin care. Skin care, especially on the skin of the body, requires moisturizing cosmetics. Therefore it is necessary to take care to keep the skin clean and healthy, one of the skin care is with a body mask. Body mask have many benefits, namely providing moisture, tightening the skin, nourishing the skin, softening the skin, cleaning pores and brightening skin tone. One of the natural ingredients that can be used for skin care is gotu kola leaf (Centella asiatica L.). Gotu kola extract has one of the ingredients, namely asiaticoside, which can stimulate collagen in skin tissue. The purpose of this study was to determine the phytochemical content of Gotu kola leaves, to determine the formulation of a good gotu kola leaf powder mask preparation, and to find out the best formulation according to probandus. The methods used in this research are phytochemical test, making body mask, pH test, organoleptic test, and hedonic test. The results of the research that has been carried out are the phytochemical tests of steroids, saponins, flavonoids, and tannins obtained positive results. The quality of the body mask produced is pH 5.41, and does not cause skin irritation. Organoleptic test of fine texture, green tea scent, greenish white color. The formulation body mask most preferred by probandus is to use a base with added 45 g (F2) of gotu kola leaf powder.
 Keywords: Body mask, gotu kola leaves (Centella asiatica L.), skin care.
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Hasana, Ani Riani, and Wibowo. "FORMULATION FACE MIST WITH GOTU KOLA (Centella asiatica) EXTRACT AS ANTIOXIDANT AND MOISTURIZING FOR ELDERLY SKIN." Proceeding of International Conference of Kerta Cendekia 2, no. 1 (2023): 124–30. http://dx.doi.org/10.36720/ickc.v2i1.504.
Full textAbstract:
Background: The skin in the elderly will experience structural, and physiological changes, and a decrease in the function of the skin, this is the basis for various skin disorders in the elderly or geriatric. The most common skin disorder in the elderly is dry skin. The gotu kola plant (Centella asiatica) has been studied to have antioxidant abilities. Face mist is included in skin fresheners or freshener cosmetics. 
 Objectives: The purpose of this study was to produce a face mist product with gotu kola extract in overcoming skin health problems in the elderly. 
 Methods: This research method begins with the manufacture of ethanol extract from gotu kola leaves, then gotu kola extract as the active ingredient in making face mist formulations. antioxidant activity of the gotu kola plant and the physical quality of the gotu kola leaf face mist was tested, namely the pH test and the organoleptic test. 
 Results: The organoleptic test obtained the characteristic odor of leaves, a liquid form with a brownish clear color. Furthermore, the pH test showed a pH range of 5. pH 5 is the pH of the preparation that is allowed for cosmetics used on the skin, especially on the face, as the pH of the skin in the Indonesian National Standard (SNI) is 4.5 - 7.5. 
 Conclusion: the formulation of this face mist is following the standard, it is hoped that this research can be continued for the development of research in increasing skin moisture levels in overcoming the skin of the elderly.
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Fioni, Debby Heldayani, Gilbert Lister, and Andika Zayani Tambunan. "Antibacterial Activity Test of Gotu Kola Leaf Extract (Centella asiatica) Against Staphylococcus aureus Bacteria Isolated from Wounds of Diabetes Mellitus Patients." Jurnal Penelitian Pendidikan IPA 9, no. 12 (2023): 10727–32. http://dx.doi.org/10.29303/jppipa.v9i12.6046.
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Staphylococcus aureus, a gram-positive bacterium, is the causative agent of diabetic foot. Traditional medicine using plants needs much further research, especially for wound healing in diabetes mellitus patients. This study is an experimental laboratory investigation on the efficacy of Gotu kola (Centella asiatica) leaf extract against wound-isolated Staphylococcus aureus. Gotu kola leaf extract (12.5%, 25%, 50%, 75%, and 100%), cefixime suspension (positive control), and sterile distilled water were tested. The results of the research showed the formation of an inhibitory zone from testing Gotu kola leaf extract against Staphylococcus aureus bacteria, where the average inhibitory zone was at concentrations of 12.5% (7.2 mm), 25% (11 mm), 50% (13.7 mm), 75% (14 .3 mm), and 100% (19.5 mm). The higher the concentration used, the larger the inhibition zone formed. Research shows that Gotu kola leaves' active substances inhibit energy formation, nucleic acid formation, cell membrane permeability, structure and function, and membrane protein lysis and damage.
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Delladari Mayefis, Rury Trisa Utami, and Mulyani Ardian Ningsih. "Antiseptic Activity of Combination Lotion of Herbal Extracts of Gotu Kola (Centella Asiatica (L). Urban) and Aloe Vera Against Psedomonas Aeruginosa Bacteria." Formosa Journal of Sustainable Research 2, no. 9 (2023): 2389–400. http://dx.doi.org/10.55927/fjsr.v2i9.4765.
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To test the antibacterial activity of antiseptic gel, a combination of gotu kola herb extract and aloe vera extract against pseudomonas aeruginosa bacteria. Experimentally using the well diffusion method with a combined concentration of gotu kola and aloe vera herbal extracts of 5%:5% (F IV), 7.5%:2.5% (F V), 7.5%:2.5% (F VI), with positive control using antic antiseptic. The antibacterial activity with the antiseptic combination of gotu kola and aloe vera herbal extracts against pseudomonas aeruginosa bacteria has a medium category inhibitory power of 18.06 mm. The data obtained was tested for normality using the Shapiro Wilk test followed by the One Way Anova test. Based on statistical tests using ANOVA, it shows that there is a significant difference between the average percentage values between groups (sig ≤ 0.05). The single lotion activity and antibacterial combination of gotu kola and aloe vera herbal extracts can inhibit the growth of pseudomonas aeruginosa bacteria
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Syahfari, Helda, Rifki Ihsan Saputra, Zikri Azham, and Saibun Sitorus. "Antibacterial Activity of Ethanol Extract of Gotu Kola (Centella asiatica L.) Leaves against Pseudomonas solanacearum: Phytochemical Study and Bioactivity Testing." Asian Journal of Agricultural and Horticultural Research 12, no. 1 (2025): 1–9. https://doi.org/10.9734/ajahr/2025/v12i1354.
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Pseudomonas solanacearum bacteria can cause wilt disease in tomatoes, chilies, tobacco, potatoes, and Solanaceae plants in general. The use of synthetic pesticides to treat wilt disease can cause negative impacts on plants, humans, and the environment, so it is necessary to find environmentally friendly pesticides. This research aims to determine the compounds contained in gotu kola (Centella asiatica L.) leaf extract, and the antibacterial effect of gotu kola leaf extract against the bacteria Pseudomonas solanacearum. The research was carried out at the Wood Properties and Product Analysis Laboratory, Department of Agricultural Agrotechnology, Samarinda State Agricultural Polytechnic, Keledang River, Samarinda Seberang District, Samarinda City, East Kalimantan from January to March 2023. Phytochemical test of gotu kola leaf extract to determine the content of secondary metabolite compounds. Consists of tannins, flavonoids, saponins, alkaloids, and steroids. To test the antimicrobial (anti-bacterial) activity, several concentrations of gotu kola leaf extract were carried out, namely 2.5% (25 ml/l); 5% (50 ml/l), 10% (100 ml/l); 15% (150 ml/l) and 20% (200 ml/l). The research results showed that the crude ethanol extract of gotu kola leaves contains secondary metabolites such as tannins, flavonoids, saponins, alkaloids, steroids. The ethanol extract of gotu kola leaves with a concentration of 50 ml/l (5%) showed more effective antibiotic activity compared to higher concentrations, namely 10% (100 ml/l), 15% (150 ml/l), and 20% (200 ml/l).
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Armadany, Fery Indradewi, Laode Muhammad Fitrawan, Fitri Rahmadani Saputri, Vica Aspadiah, and Henny Kasmawati. "Combination of Gotu Kola (Centella asiatica (L.)) Ethyl Acetate Extract and Virgin Coconut Oil (VCO) as Burn Healing." Journal Borneo 3, no. 2 (2023): 95–105. http://dx.doi.org/10.57174/j.born.v3i2.89.
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Burns result from exposure to heat sources like fire, chemicals, or radiation and can lead to tissue loss or damage. Traditional healing of burns often involves using herbal remedies like gotu kola and coconut, typically oil extracts. This study aims to identify the healing effects of burns by administering a combination of ethyl acetate extract of gotu kola herb and virgin coconut oil (VCO) to mice. The mice were divided into 7 groups, namely negative control (K(-)) was given tween 20; positive control (K(+)): burn topical medicine on the market, P1: 10% Ethylacetate extract in tween 20; P2: VCO; P3: Ethyl acetate extract 10% and VCO 50% in tween 20; P4: 5% Ethyl acetate extract in VCO; P5: extract 10% Ethyl acetate in VCO and treated for 21 consecutive days with a frequency of twice a day. The results showed that the combination of 10% ethyl acetate extract of gotu kola herb in VCO exhibited the highest healing activity for burns, comparable to the positive control (K(+)) topical medicine on the market. The higher the extract concentration and VCO, the better the healing activity of burns.
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Farhana, Kun Marisa, Rusdy Ghazali Malueka, Samekto Wibowo, and Abdul Gofir. "Effectiveness of Gotu Kola Extract 750 mg and 1000 mg Compared with Folic Acid 3 mg in Improving Vascular Cognitive Impairment after Stroke." Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/2795915.
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This study aimed to determine the effectiveness of gotu kola (Centella asiatica) in improving cognitive function in patients with vascular cognitive impairment (VCI). This study uses a quasi-experimental design. Subjects in this study were patients with poststroke cognitive impairment who were treated at two hospitals in Yogyakarta, Indonesia. The number of subjects was 48: 17 subjects were treated with 1000 mg/day of gotu kola extract, 17 subjects treated with 750 mg/day of gotu kola extract, and 14 subjects treated with 3 mg/day of folic acid for 6 weeks. A Montreal Cognitive Assessment-Indonesian version (MoCA-Ina) was conducted at the beginning of treatment and after 6 weeks of therapy. It was found that all trials effectively improved poststroke VCI based on MoCA-Ina scores over the course of the study. There is no significant difference in ΔMoCA-Ina (score at the 6th week of treatment − score at the beginning) mean score among the three groups, indicating that gotu kola is as effective as folic acid in improving poststroke VCI. Gotu kola was shown to be more effective than folic acid in improving memory domain. This study suggested that gotu kola extract is effective in improving cognitive function after stroke.
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Poernomo, Hendri, Mochammad Taha Ma'aruf, and Luh Gede Pradnyani. "Acute Toxicity and Allergy Test of Pegagan Leaf Extract (Centella asiatica) on Mice (Mus muscullus)." Interdental Jurnal Kedokteran Gigi (IJKG) 20, no. 3 (2024): 467–73. https://doi.org/10.46862/interdental.v20i3.10527.
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Introduction: Gotu kola (Centella asiatica) is a type of plant that is often used as a traditional medicine that has the properties to accelerate wound healing, rheumatic inflammation, asthma, hemorrhoids, dysentery, fever, and as a blood enhancer. The use of plants as medicinal raw materials is increasing, so it is necessary to prove its safety by conducting acute toxicity tests and allergy tests. Material and Method: in vivo laboratory experiment with quasi experimental method and post test-Only Control Group Design with histopathological observations on the liver of mice. Mice will be grouped into 5 groups and each group consists of 5 mice consisting of 1 control group and 4 treatment groups. The treatment group was given gotu kola leaf extract orally and observations were made for 14 days. Result and Discussion: obtained the results of acute toxicity test research, obtained LD50 value is 12.5gr/kg BW (mild toxic), on microscopic observation in the control group there was no damage to the liver, while in the treatment group there were changes in the form of liver damage. For acute toxicity, the weight of mice after being given gotu kola leaf extract was tested using Shapiro Wilk and Kruskal Wallis tests. From the analysis results, there was no significant difference. Conclusion: Gotu kola leaf extract does not cause toxic effects on mice mortality and also does not cause allergies in mice.
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Mardhiyah, Tarra Ainul, and Linda Rosalina. "Kelayakan Toner Wajah Ekstrak Daun Teh Hijau (Camellia Sinensis) dan Daun Pegagan (Centella Asiatica) untuk Perawatan Kulit Wajah Berjerawat." MASALIQ 3, no. 4 (2023): 501–11. http://dx.doi.org/10.58578/masaliq.v3i4.1190.
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Green tea leaf extract facial toner and gotu kola leaves are facial care cosmetics formulated for acne-prone skin types. This cosmetic is made from natural ingredients in the form of green tea leaves and gotu kola leaves which have been dried with a mixture of preservatives and other chemicals. This facial toner functions to moisturize and refresh facial skin, remove excess oil on facial skin and can help close pores on the face. This facial toner contains antioxidants which are great for warding off free radicals that cause acne-prone skin. Purpose: To analyze the facial toner extract of green tea leaves and gotu kola leaves in terms of laboratory tests, organoleptic tests, and organoleptic tests. Method: this research method is an experimental research method. The results of this study based on organoleptic tests showed that the color, aroma, absorption, and preference of the panelists had a fairly high rating level. For laboratory tests, facial toner extracts from green tea leaves and gotu kola leaves had a pH test that was in accordance with the standard pH of facial skin, namely 6.5, which was good for facial skin and the homogeneity test found that all formulations in this toner were homogeneous. In conclusion: facial toner extracted from green tea leaves and gotu kola leaves is suitable for use as a facial toner in terms of laboratory tests (pH test and homogeneity test), organoleptic tests (color, aroma and absorption), and panelist preference test (hedonic).
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Vera Iriani Abdullah, Siti Rusyanti, Sumarni, et al. "Gel Formulation Test of Gotu Kola Leaf Extract (Centella Asiatica) 15% For Handling Striae Gravidarum." Journal of Pharmaceutical Negative Results 13, no. 4 (2022): 1124–27. http://dx.doi.org/10.47750/pnr.2022.13.04.156.
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Hormonal changes during pregnancy will impact the skin so that the skin of pregnant women will be vulnerable and at significant risk for striae gravidarum in several areas of the body, including the abdomen, breasts, calves, and thighs. This will impact the quality of life, the incidence of pelvic organ prolapses, and rupture of the perineum due to a lack of collagen in the body. Techniques for treating striae gravidarum have been developed in several methods, including micro-needling and fractional CO2 laser, vitamin C, the use of 0.1% tretinoin cream to the use of frequency radio microneedle (FMR). This treatment aims to help increase, maintain and stabilize collagen in the skin. Gotu kola leaf (Centella Asiatica) is one of the plants that can stimulate the production of collagen I and moisturize the skin because it contains compounds such as saponins, asiaticoside, Asiatic acid, madecassoside, and triterpenes. This plant is also anti-infectious, anti-leprosy, anti-syphilis, and skin cell revitalization. This study aimed to test the effectiveness of a gel based on Gotu kola leaf with a concentration of 15% for treating striae gravidarum. This research method is quasi-experimental with a one-group pre-test post-test design. The population and research sample consisted of 3 respondents; each respondent was assessed in 4 areas: the breast, abdomen, thigh, and calf. The results show that because the significance level is more significant than α (0.130 > 0.05), there is not enough reason to accept H0, and we also get the difference between the average value before and after being given a 15% concentration, which is 1.5, which means the average decreases. Conclusion Gel preparations of Gotu kola leaf extract (Centella Asiatica) with a concentration of 15% are effective in treating striae gravidarum degrees 1,2, and 3.
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Fernenda, Larysa, Arba Pramundita Ramadhani, and Yandi Syukri. "Aktivitas pegagan (Centella asiatica) pada dermatologi." Jurnal Sains Farmasi & Klinis 9, no. 3 (2023): 237. http://dx.doi.org/10.25077/jsfk.9.3.237-244.2022.
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Pegagan (Centella asiatica L.) is a herbal plant used in dermatology that has activity in treating skin diseases and skin lesions such as excoriations, burns, hypertrophic scars, antioxidants, anti-aging, skin whitening, and as a cosmetic ingredient. This review aims to collect data regarding the activity of Centella asiatica herb extracts in dermatology in both preclinical and clinical trial identification is done by searching literature through media Science Direct and Google Scholar using the keywords ''Centella asiatica'', ''Gotu kola'', ''dermatology'', ''cosmetics'', and ''whitening''. The search was based on the inclusion and exclusion criteria that had been set. The literature results show that the chemical constituents of Centella asiatica, such as asiaticoside, madecassoside, asiatic acid, and madecassic acid, are phytochemicals that play an essential role in the pharmacological activity of Centella asiatica in dermatology as a treatment and skin care. In both preclinical and clinical tests, it was shown that administration of Centella asiatica was capable of proliferating fibroblasts, activating the Smads pathway, increasing collagen synthesis, reducing metalloproteinase activity by increasing collagen deposition, and reducing melanin content in melanocytes so that it can modulate melanogenesis by inhibiting the expression of tyrosinase mRNA.
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Srijita, Mondal Ghosh. "Centella asiatica A Potential Herb in the Arena of Dermatology." Journal of Bioresearch vOL 3 , July - December, 2024, NO 2 (2024): 3–11. https://doi.org/10.5281/zenodo.10798199.
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<strong>Abstract</strong>: Centella asiatica a perennial, aromatic medicinal herb known as “miracle elixir of life” has been used as folkmedicine and also scientifically oriented medicine. The medicinal herb,Centella asiatica (L.) Urban known as Gotu kola hasbeen reported to exhibit a wide range of pharmacological activities. In particular, a remarkable body of scientific researchexists on the therapeutic properties of preparations of C. asiaticaor its triterpenes in the treatment of skin diseases. Centellaasiatica has potent antioxidant and anti-inflammatory properties. The active compounds including penta-cyclic triterpenes,mainly Madecassoside, Asiaticoside, Asiatic and Madecassoside are effective in healing skin disorders such as repairing smallwounds caused by injury or burns, heals atopic dermatitis, psoriasis, acne, eczema etc. TECA is purified standardized extractof Centella asiatica composed of Madecassic acid, Asiaticoside, and Asiatic acid.The mechanism involve wound treatment withTECA that collagen synthesis, fibroblast proliferation, management of keloids, regulating inflammatory cytokines and chemokinesvia TGF- /Smad Signaling, NF- B Signaling. This madecassoside may significantly inhibit the production of IL-1 releasedby P. acnes stimulated THP-1 cells that might suppress P. acnes-induced inflammatory response. Also Centellaplay a pivotalrole in cosmetology treating photo-ageing skin, cellulite and striae. The C. asiatica extract regulate the metabolism happeningin the cells of the connective tissue, shows anti-inflammatory and draining activity and modulates microcirculation.<strong>Keywords</strong>: Acne, Atopic Dermatitis, Burns, Centella asiatica, Madecassoside, Photo-ageing.
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Devi, Dwitya Devi Nurlistyo, Cici Darsih, Nunung Yuniarti, Bondan Ardiningtyas, and Marlyn Dian Laksitorini. "Formulation and Antioxidant Activity of Gotu Kola Jelly Candy with Plant-based Polymers as a Gelling Agent." Majalah Obat Tradisional 29, no. 3 (2024): 266. https://doi.org/10.22146/mot.89699.
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Centella asiatica or gotu kola has a long history as a brain supplement. Gotu kola supplements are sold as liquid and dried extract which is less attractive for a younger generation. Jelly candy is an alternative dosage form with better acceptability across ages. However, the use of animal-derived polymers such as pork gelatine in the candy restricts those who practice vegetarian and halal lifestyles from consuming the products. This study aims to explore plant-based polymers glucomannan and kappa-carrageenan as gelling agents in the preparation of gotu kola jelly candy. Preparation of the jelly candy formula was designed based on Simplex Lattice Design. Evaluation of physical characteristics of jelly candy includes organoleptic, weight uniformity, moisture content, pH, and elasticity. The antioxidant activity of gotu kola before and after the manufacturing process was evaluated. The results showed that a combination of kappa-carrageenan 1.33% and glucomannan 0.67% is the optimum formula. Adding more proportion of kappa-carrageenan reduced jelly elasticity and moisture content. While adding glucomannan improved its elasticity responses but increased moisture content. Evaluation of the antioxidant activity of gotu kola in jelly candy suggested that gotu kola experienced a significant reduction in antioxidant activity following the production process. The IC50 of the crude extract initially was129.23 ppm while post jelly candy manufacturing, the IC50 increased to 197.49 ppm. This study suggested that improvement in extraction and production processes is necessary to maintain gotu kola antioxidant activity.
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Kumalasari, Ika Dyah, Lubna Nur Fathiyya, and Retnosyari Septiyani. "Physicochemical, Microbiological and Organoleptic Properties of Cowpeas (Vigna Unguiculata) Yoghurt with The Addition of Gotu Kola Leaf (Centella Asiatica (L.) Urban) Extract." Sains Malaysiana 53, no. 1 (2024): 123–34. http://dx.doi.org/10.17576/jsm-2024-5301-10.
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Cowpea yogurt is a functional food product made from cowpeas and gotu kola leaves. This mixture of cowpeas and gotu kola leaves is expected to increase its functional value i.e., protein and antioxidant activity. This research aims to analyze the physicochemical, microbiological, and organoleptic properties of cowpeas yogurt with the addition of gotu kola leaf extract. The study used a Completely Randomized Design (CRD) with one factor, with the ratio of cowpea’s milk: gotu kola leaf extract, namely F1 (98%: 2%), F2 (96%: 4%), F3 (94%: 6%), K2 (100%: 0%), and K1 (100% pure milk). Testing parameters include viscosity, pH value, (moisture, ash, fat, protein, carbohydrate) content, antioxidant activity, total lactic acid bacteria, and organoleptic (color, aroma, taste, texture). The results showed that the highest pH and viscosity values in K2 were 3.77 and 419.59 cP; the highest moisture content in F3 was 85.04%; the highest ash, fat, and carbohydrate content in K2 were 0.62%, 1.87%, and 10.21%; the highest protein content in F1 was 3.25%; the highest antioxidant activity in F3 with an IC50 value of 87.008 ppm; the total lactic acid bacteria in K2 met the minimum SNI requirements of 107 CFU/mL; and K2 showed the most favorable overall organoleptic test. This study shows that the addition of gotu kola leaf extract affects on the physicochemical, microbiological, and organoleptic properties of cowpea yogurt.
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Salsabila, Zahra, Wimala Hardyawati, Muhammad Bintang Ramadhan, et al. "Incorporation of Cod liver oil to Centella asiatica (Gotu Kola) gummy candy as a cognitive enhancement supplement." Journal of Research in Pharmacy 29, no. 3 (2024): 1067–77. https://doi.org/10.12991/jrespharm.1694222.
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This study aimed to incorporate Cod Liver Oil (CLO) oil in Centella asiatica (Gotu kola) gummy candy and to evaluate its effect on cognitive function in the animal model. Cognitive impairment among children, particularly those identified as slow learners has been a concern for many parents including health authorities and the Federal Government. The current study explored the potency of Gotu kola and CLO combination in improving brain health. The gummy candy formulation was chosen to address children's taste and palatability issues. However, incorporating CLO into the formula might affect the physical properties of the gummy candy. This research uses the simplex lattice design (SLD) to determine the optimum proportion of cod liver oil and gelatine that produce good gummy physical characteristics. The physical characteristics of the gummies that have been evaluated include Moisture Content, Weight Uniformity, pH, and Elasticity. The studies also employed a texture analyzer to determine the gummy texture. Hedonic tests were performed to confirm the physical properties data. Pharmacological evaluation of the active ingredients included antioxidant activity tests using the DPPH assay, and cognitive tests using T-Maze assay. These studies suggested that a combination of 10% gelatine and 5% cod live oil produced the most acceptable physical characteristics. The addition of cod liver oil improved the antioxidant activity of Gotu kola. The optimum formula containing 4 grams of CLO and 4 grams of Gotu kola extract showed a strong antioxidant activity with an IC50 of 32.53 μg/ml. In the mouse memory test, administering 7 grams of CLO in Gotu kola extract gave a significant reduction in the time required to find food in the T-maze test. These studies suggest that fish oil can be incorporated into a gummy candy with acceptable physical properties to enhance memory.
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Shivananjappa, Mahesh, Meghana H D, Manasa R, Santosha D U, and Shekhara Naik R. "Wound healing activity of Centella Asiatica." IP Journal of Nutrition, Metabolism and Health Science 6, no. 1 (2023): 1–6. http://dx.doi.org/10.18231/j.ijnmhs.2023.001.
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is a medicinal herb in family Commonly known as Brahmi, Gotu kola, Ondelaga, Indian pennywort and found in swampy areas and temperate regions. It has many pharmacological properties like anticancer, antidiabetic, immunity booster, memory enhancer, wound healing, anticancer, neuroprotective. All extracts of facilitate the wound healingprocess in both incision and burn wounds by inhibiting inflammation, inducing collagen synthesis, inducing vasodilation and promoting angiogenesisThis review aimed to explore the wound healing activity of , the botanical description, phytochemistry, traditional uses are included in this review.
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Astuti, Puji, and Diwi Acita Irawati. "The Effectiveness of Meniran (Phyllanthus niruri) and Gotu Kola (Centella asiatica) Herbs on Broiler Chicken Performance." Bantara Journal of Animal Science 4, no. 2 (2022): 98. http://dx.doi.org/10.32585/bjas.v4i2.2951.
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This study aims to determine the performance of broiler chickens given Phyllanthus niruri and Centella asiatica extracts. The research was conducted for 32 days at the Animal Husbandry Practice Unit (UPT) of the Karanganyar Animal Husbandry Academy. The material used was 100 broiler Cobb strains aged 4 days, kept in 20 experimental units, each unit consisting of 5 chickens with an average initial weight of 111,08 ± 4.74 g. The first treatment (T0) control, chicken without giving P. niruri and C. asiatica extracts, the second treatment (T1) the chicken was given 10 ml P. niruri extract per liter of drinking water, the third treatment (T2) the chickens were given 5 ml P. niruri extract and 5 ml C. asiatica extract, per liter of drinking water, the fourth treatment (T3) of chickens was given C asiatica extract 10 ml per liter of drinking water. The variables observed included drinking water consumption, feed consumption, average daily gain, and feed convertion ratio (FCR). The design used was a completely randomized design (CRD). The data were analyzed for variety and if there was a significant effect of the treatment, it was continued with the Duncan Multiple Distance Test to determine differences in treatment. The results showed that drinking water consumption, and average daily gain were not significantly different between treatments, feed consumption (g/head/day) and feed convertion ratio was significantly different between treatments. The conclusion of this research is that giving P. niruri and C. asiatica extracts in drinking water affect the performance of broiler chicken.
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Toribio, Micah P., Kirsten Carrie O. Salarza, Raiza Mae G. Quemada, and Cheimarlene Gayle S. Rasonabe. "Gotu Kola and Banana Flower as an Alternative Shampoo." Journal of Multidisciplinary Cases, no. 42 (March 13, 2024): 11–24. http://dx.doi.org/10.55529/jmc.42.11.24.
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Investigates the efficacy of incorporating extracts from Gotu Kola (Centella asiatica) and Banana Flower (Musa spp.) into natural shampoo formulations. Both botanicals are renowned for their traditional uses and potential benefits for hair care. The study evaluates the cleansing, conditioning, and revitalizing properties of these extracts, emphasizing their eco-friendly and sustainable attributes. Preliminary findings suggest promising results in terms of cleansing efficiency and hair health. The exploration of Gotu Kola and Banana Flower as alternative shampoo ingredients aligns with the growing demand for sustainable and plant-based personal care products, offering potential alternatives to conventional chemical-laden shampoos.
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Dzulasfi, Suhartini, and Agha Izha Fahiza. "PEMBUATAN DAN UJI MUTU FISIK KRIM EKSTRAK HERBA PEGAGAN (Centella asiatica) (L.)." Jurnal Kesehatan Yamasi Makassar 7, no. 2 (2023): 19–25. http://dx.doi.org/10.59060/jurkes.v7i2.304.
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This study aims to make and test the Physical Quality Test of Centtella asiatica (L) extract of Centtella asiatica (L) in cream dosage forms with 0.5% and 1% extract concentrations. The type of research carried out is a laboratory experimental research by making Centella asiatica (L) herbal cream and testing the physical quality of the cream by conducting organoleptic, homogeneity, pH and dispersibility tests. The results of the observation of the pH test at a concentration of 0.5% is 6.13, a concentration of 1% is 6.47 while the dispersion test at a concentration of 0.5% is 5.1 cm, and a concentration of 1% is 5.2 cm. The results of the research on making and testing the physical quality of the cream of gotu kola herb extract 0.5% and 1% met the requirements for the physical quality test of cream preparations.
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Pratiwi Dyah Indriyani, Tyas Prasetyaningrum, and Lisa Adhani. "Pembuatan Sediaan Gel Dari Ekstrak Herba Pegagan (Centella Asiatica L. Urban) Sebagai Obat Luka Sayat." PENDIPA Journal of Science Education 7, no. 2 (2023): 259–64. http://dx.doi.org/10.33369/pendipa.7.2.259-264.
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Gotu kola (Centella asiatica L. Urban) contains the active ingredient saponin, an asiaticoside compound that acts as an antibiotic and spurs the production of collagen I, a protein that accelerates the wound healing process. The purpose of this study was to formulate a gel material from ethanol extract of gotu kola herb that meets the requirements of a good gel. In this study, gotu kola saponins were obtained from the extraction process carried out using a stirred extractor at 65°C, 350 rpm and 30, 60, 90, 120, and 150 minutes. Identification of saponins was done using FTIR (Fourier Transform InfraRed). The gel formulation was made with concentrations of 5%, 10%, and 15%. A mass transfer coefficient of 0.01240 min-1 was obtained. The IR spectrum results showed the presence of O-H groups, C-H alkane groups (CH2, CH3), C=O carbonyl groups and C-O ester groups. The results of the evaluation carried out with the three gel concentrations in the organoleptic test, pH test, viscosity test, stability test, adhesion test and spread ability test met the requirements of a good gel.
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Hernayanti, Hernayanti, and Sri Lestari. "Penurunan Toksisitas Kadmium Dengan Kelator Alami Pegagan (Centella Asiatica) Ditinjau dari Kadar Malondialdehid (MDA) dan Superoksida Dismutase (SOD)." Journal of Bionursing 2, no. 1 (2020): 47–52. http://dx.doi.org/10.20884/1.bion.2020.2.1.41.
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Cadmium (Cd) is a heavy metal that is toxic to humans. Cadmium will bind to metalotionin in the liver to form Cd+MT bonds, which triggers the formation of free radicals and causes oxidative stress. Oxidative stress characterized by elevating of MDA and decreasing of antioxidant enzyme such as SOD. Gotu kola(Centella asiatica) contains active compounds medecassoside that can function to chelate Cd, decreasing MDA level caused by Cd-Mt bounded and generate SOD level.The aim of this study is to know the effect of Pegagan as natural chelator for Cd poisoning and as antioxidant. Twenty four rats were used in this research and divided into six groups with four replications. Group 1 (C1) as healthy. Group 2 (C2) was only given 14 mg/200 gBW of CdSO4 for 35 days. Group 3, 4, 5 and 6 were given CdSO4 14 mg / 200kgBB and gotu kola extract dose of 20 mg/200gBB, 40 mg/200gBB, 60 mg/200gBB, 80 mg / 200gBB, for 21 days. The parameters studied were blood MDA and SOD level. Measuring parameters were done on the 36th day after administration of Centella extract. Data were analyzed by Anova and followed by Duncan test The results showed that Centella all doses can reduce MDA level and increase SOD level. A dose of 40mg / 200gBB Centella extract has been effective in reducing MDA level as well as increasing SOD level. It can be concluded that dose of 40mg/200gBB can use as a natural chelator of Cd and as antioxidant for Cd poisoning.
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Balu, Anbarasan. "Bioactive gel formulation of Centella Asiatica and Aloe vera for accelerated wound healing." Journal of Medical Pharmaceutical and Allied Sciences 13, no. 6 (2024): 6900–6908. https://doi.org/10.55522/jmpas.v13i6.6749.
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Centella asiatica, also known as Gotu kola or Indian pennywort, has been used in traditional medicine systems like Ayurveda and Traditional Chinese Medicine. Recently, it has gained global recognition, especially in Korean skincare, due to its active components, such as asiaticoside, madecassoside, and triterpenoids, which promote wound healing, antioxidant protection, and anti-aging effects. Aloe vera, a succulent used medicinally for over 5,000 years across various cultures, contains over 70 biologically active compounds with anti-inflammatory, antioxidant, and healing properties. A randomized trial has shown its effectiveness in treating plaque psoriasis. This study aims to formulate a gel combining triterpene compounds from Centella asiatica with Aloe vera to enhance wound healing in diabetic patients. Triterpenes were extracted from Centella asiatica using ethanol via the maceration method, while Aloe vera's bio-enhancing properties improved absorption. The gel, formulated with Centella asiatica extract, Aloe vera gel, Carbopol 940, propylene glycol, benzyl alcohol, and sorbitan solution, was prepared in four concentrations (0.5%, 1%, 1.5%, 2%). Characterization studies, including pH, viscosity, spreadability, extrudability, and in-vitro release, were performed. Stability studies ensured the gel’s usability. Results indicate that the combination of Centella asiatica and Aloe vera shows promise for enhanced wound healing, particularly in diabetic patients.
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Pal, Rashmi Saxena, Yogendra Pal, Pranay Wal, and Vijender Singh. "ISOLATION AND CHARACTERIZATION OF N-HEPTACOSANYL OLEATE FROM THE WHOLE AERIAL PARTS OF CENTELLA ASIATICA LINN." Asian Journal of Pharmaceutical and Clinical Research 9, no. 9 (2016): 23. http://dx.doi.org/10.22159/ajpcr.2016.v9s3.13427.
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ABSTRACTVarious studies have already been performed involving the whole aerial parts of Centella asiatica (L.) (Umbelliferae), commonly known as gotu kola orjalbrahmi, and thus, the present investigation has been carried out for the phytochemical study of an ethanolic extract of the aerial parts of C. asiatica.To perform this activity, the drug (1.5 kg) was exhaustively extracted in 95% ethanol using Soxhlet apparatus. The column chromatography wasperformed then for isolating the various phytoconstituents using the solvents of increasing polarity from petroleum ether to methanol. The isolatedcompounds were structurally elucidated using various spectral data analysis, i.e. infrared,1H nuclear magnetic resonance (NMR),13C NMR, and positiveion fast atom bombardment mass spectrometry. One of the isolated compounds was characterized as n-heptacosanyl oleate.Keywords: Whole aerial parts, Centella asiatica, Soxhlet, Column, Heptacosanyl oleate.