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Journal articles on the topic 'Gout'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Kim, Tkhe Van, V. D. Zavadovskaya, I. Yu Degtyarev, et al. "Modern methods of visualization of gouty tophi." Medical Visualization 28, no. 4 (2024): 112–32. https://doi.org/10.24835/1607-0763-1382.

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Objective: to present modern methods of visualization of gouty tophi.Materials and methods. A search was made for scientific publications and clinical recommendations in the PubMed and Google Scholar information and analytical systems for 2007-2022, using the following words: diagnosis of gout, X-ray gout, gout ultrasound, gout CT, gout DECT, gout MRI, gout scintigraphy.Results. 894 articles were analyzed, 42 of which were used to compile the review. Search results - blocks of articles were created, within which the articles were analyzed to study diagnostic features.Conclusion. Early diagnosi

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A.Wahyu, Larasati, and Pramarta Y. Dwiputra. "Differences The Incidence of Hyperuricemia in Families with Gouty Arthritis and Families Without Gouty Arthritis in Buleleng Regional General Hospital, Bali, Indonesian." Jurnal Indonesia Sosial Teknologi 5, no. 4 (2024): 1408–14. http://dx.doi.org/10.59141/jist.v5i4.1010.

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The most common manifestation of hyperuricemia is gout. Hyperuricemia is the leading cause of gout. It is about five times more common than gout. The heritability of hyperuricemia and gout is about 73%, and 40-50% of patients have a family history of gout. Indonesia, especially Bali, has a high prevalence of hyperuricemia in families with gout at 26.6%. Therefore, we performed this study to look for differences in the incidence of hyperuricemia in families with gouty arthritis and families without gouty arthritis. In an unpaired case-control study, which is the target population is Balinese, t

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Scipioni, Rosa, Luciano Frate, Valentino Di Tomasso, Michele Saltarelli, Francesco Carubbi, and Marco Petrarca. "Images in clinical medicine: gouty arthritis with osteomyelitis." Italian Journal of Medicine 12, no. 4 (2018): 270–72. http://dx.doi.org/10.4081/itjm.2018.1047.

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Gout is one of the most common inflammatory arthropathies, characterized by the deposition of monosodium urate crystals in the synovial membrane, articular cartilage and periarticular tissues and leading to inflammation. The natural history of articular gout is typically composed of four periods: asymptomatic hyperuricemia, episodes of acute attacks of gout (acute gouty arthritis) with asymptomatic intervals (intercritical gout), and chronic tophaceous gout. Tophi develop in 12-35% of gouty patients without adequate control of uricemia. Initially, they do not cause significant complaints or fu

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Rossiyah, Nella. "RISK FACTOR FOR GOUT AND PREVENTION : A SYSTEMATIC REVIEW." Journal of Advance Research in Medical & Health Science (ISSN: 2208-2425) 9, no. 3 (2023): 68–73. http://dx.doi.org/10.53555/nnmhs.v9i3.1615.

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Due to the supersaturation of uric acid, monosodium urate monohydrate crystals accumulate in the tissues, causing gout. Gout is characterized by elevated serum urate levels, acute gouty arthritic episodes, the production of tophi, gouty nephropathy, and uric acid stones. Until now there is no definite percentage/number of people with gout arthritis in the world, due to differences in research sampling methods in determining the number of sufferers of this disease. However, especially in America, there has been a significant increase in cases of gouty arthritis in the last 10 years. Uric acid i

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Putri, Sari Ananda, Naziyah Naziyah, and Cholisa Suralaga. "Efektivitas Kompres Hangat pada Lansia terhadap Penurunan Nyeri Gout Arthritis di Posbindu Kemuning Baktijaya Depok." Malahayati Nursing Journal 5, no. 7 (2023): 2267–79. http://dx.doi.org/10.33024/mnj.v5i7.9047.

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ABSTRACT A metabolic condition known as gouty arthritis or gout is characterized by acute joint inflammation caused by the formation of crystallized uric acid. Uric acid levels are elevated in some people who consume purine-rice foods. There are many different factors that contribute to gouty arthritis, such as eating habits that increase uric acid levels and a diet high in purines. Losing weight, drinking plenty of water, avoiding foods that can cause gouty arthritis are ways to prevent it. To examine the effect of warm compress on decreasing pain in elderly with arthritis gout at Posbindu Ke

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Anis Rahmawati. "Potensi Kompres Hangat Jahe Merah Sebagai Terapi komplementer Terhadap Pengurangan Nyeri Artritis Gout." Jurnal Ilmiah Pamenang 3, no. 1 (2021): 7–15. http://dx.doi.org/10.53599/jip.v3i1.76.

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AbstrakArtritis gout merupakan salah satu penyakit Metabolisme yang disebabkan oleh penumpukan monosodium urate monohydrate crystals pada sendi. Gejala utama yang lazim dirasakan oleh penderita gout artritis adalah nyeri sendi. Untuk mengatasi nyeri terapi farmakologi yang lazim diberikan adalah obat obatan analgesik. Penggunaan antinyeri pada penderita gout artritis yang umumnya dibutuhkan dalam jangka waktu yang panjang dan banyak yang timbulnya efek samping sehingga terapi non farmakologis diharapkan menjadi alternatif untuk mengurangi nyeri artritis gout sehingga menurunkan penggunaan obat

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Gregoline, PE, ML Peshoff, and MJ Trepal. "Gout and hypothyroidism." Journal of the American Podiatric Medical Association 87, no. 8 (1997): 394–96. http://dx.doi.org/10.7547/87507315-87-8-394.

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A case of gout in a patient with primary hypothyroidism has been presented. Often missed as a companion of gout, hypothyroidism has a frequency of occurrence with gout that is significant and is probably a precipitating factor in these gouty attacks. The physician should be alert for signs and symptoms of this often occult disease in patients with hyperuricemia and gout.

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Aden, Durre, Prajwala Gupta, and Minakshi Bharadwaj. "Fine-needle aspiration cytology of periarticular nodule – Atypical presentation of gouty tophi: A report of two cases." Cytojournal 19 (August 5, 2022): 48. http://dx.doi.org/10.25259/cytojournal_6_2022.

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Gout is a chronic arthropathy caused due to the deposition of monosodium urate crystals. Gouty tophus can be the initial presenting feature of gout with or without any clinical symptoms. Demonstration of urate crystals in synovial fluid or biopsy helps in confirming the diagnosis of gout. However, fine-needle aspiration cytology (FNAC) of periarticular soft-tissue nodules is a valuable tool in the diagnosis of gout. We present two such cases of isolated soft-tissue lesions wherein the initial diagnosis of gouty tophus was made on FNAC and subsequently followed by a clinical and biochemical wor

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Zhang, Yingling, Simin Chen, Man Yuan, Yu Xu, and Hongxi Xu. "Gout and Diet: A Comprehensive Review of Mechanisms and Management." Nutrients 14, no. 17 (2022): 3525. http://dx.doi.org/10.3390/nu14173525.

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Gout is well known as an inflammatory rheumatic disease presenting with arthritis and abnormal metabolism of uric acid. The recognition of diet-induced systemic metabolic pathways have provided new mechanistic insights and potential interventions on gout progression. However, the dietary recommendations for gouty patients generally focus on food categories, with few simultaneous considerations of nutritional factors and systemic metabolism. It is worthwhile to comprehensively review the mechanistic findings and potential interventions of diet-related nutrients against the development of gout,

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Tabi-Amponsah, Adwoa Dansoa, Sarah Stewart, Graham Hosie, Lisa K. Stamp, William J. Taylor, and Nicola Dalbeth. "Gout Remission as a Goal of Urate-Lowering Therapy: A Critical Review." Pharmaceuticals 16, no. 6 (2023): 779. http://dx.doi.org/10.3390/ph16060779.

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Urate-lowering therapies for the management of gout lead to a reduction in serum urate levels, monosodium urate crystal deposition, and the clinical features of gout, including painful and disabling gout flares, chronic gouty arthritis, and tophi. Thus, disease remission is a potential goal of urate-lowering therapy. In 2016, preliminary gout remission criteria were developed by a large group of rheumatologists and researchers with expertise in gout. The preliminary gout remission criteria were defined as: serum urate < 0.36 mmol/L (6 mg/dL); an absence of gout flares; an absence of tophi;

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Liu, Lu, Shuang He, Lin Jia, et al. "Correlation analysis of serum TLR4 protein levels and TLR4 gene polymorphisms in gouty arthritis patients." PLOS ONE 19, no. 4 (2024): e0300582. http://dx.doi.org/10.1371/journal.pone.0300582.

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Objective The Toll-like receptor (TLR) 4-mediated nuclear factor kappa B (NF-κB) signaling pathway regulates the production of inflammatory factors and plays a key role in the pathogenesis of gouty arthritis. The aim of the present study was to investigate the link among TLR4 gene polymorphisms at various loci, protein expression, and gouty arthritis susceptibility. Methods Between 2016 and 2021, a case-control study was used to collect a total of 1207 study subjects, including 317 male patients with gouty arthritis (gout group) and 890 healthy males (control group). The association between go

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Tseng, Chia-Chun, Man Chun Wong, Wei-Ting Liao, et al. "Systemic Investigation of Promoter-wide Methylome and Genome Variations in Gout." International Journal of Molecular Sciences 21, no. 13 (2020): 4702. http://dx.doi.org/10.3390/ijms21134702.

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Current knowledge of gout centers on hyperuricemia. Relatively little is known regarding the pathogenesis of gouty inflammation. To investigate the epigenetic background of gouty inflammation independent of hyperuricemia and its relationship to genetics, 69 gout patients and 1455 non-gout controls were included. Promoter-wide methylation was profiled with EPIC array. Whole-genome sequencing data were included for genetic and methylation quantitative trait loci (meQTL) analyses and causal inference tests. Identified loci were subjected to co-methylation analysis and functional localization with

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Afzal, Asma, Shameem Ahmad Rather, and Shabir Ahmad Bhat. "Gouty Arthritis and Its Appraisal in Greco-Arab (Unani) Medicine." International Journal of Research and Review 11, no. 6 (2024): 818–27. http://dx.doi.org/10.52403/ijrr.20240688.

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A typical excruciating type of inflammatory arthritis, Gout, often affects big toe joint and sometimes other joints and viscera as well. In Greco-Arab (Unani) medicine gout is known as Niqris. There is ample literature regarding gouty arthritis available in the treatise of Greco-Arab medicine, an age old existing medicinal system. The aim of this study is to explore the medicinal treasure for gout in Greco-Arab medicine, correlate it with the modern science to amplify the knowledge and widen the field of research avenues. More efficient, cost-effective management of gouty arthritis with least

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Shukla, Rahul, Ronald B. Vender, Ayman Alhabeeb, Samih Salama, and Frank Murphy. "Miliarial Gout (A New Entity)." Journal of Cutaneous Medicine and Surgery 11, no. 1 (2007): 31–34. http://dx.doi.org/10.2310/7750.2007.00002.

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Background: Tophaceous gout typically presents as a subcutaneous, nodular collection of monosodium urate crystals sharply circumscribed from surrounding tissues. Although intradermal cutaneous manifestations of gout have been described, no reported cases of miliarial gout remain. Objective: We describe the first known presentation of miliarial gout and list other uncommon cutaneous manifestations of gouty tophi. The treatment of miliarial gout is discussed, as well as risk factors predisposing an individual to the development of intradermal tophi. Results: Miliarial gout is an intradermal phen

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Horváthová, Veronika, Jana Bohatá, Markéta Pavlíková, et al. "Interaction of the p.Q141K Variant of the ABCG2 Gene with Clinical Data and Cytokine Levels in Primary Hyperuricemia and Gout." Journal of Clinical Medicine 8, no. 11 (2019): 1965. http://dx.doi.org/10.3390/jcm8111965.

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Gout is an inflammatory arthritis influenced by environmental risk factors and genetic variants. The common dysfunctional p.Q141K allele of the ABCG2 gene affects gout development. We sought after the possible association between the p.Q141K variant and gout risk factors, biochemical, and clinical determinants in hyperuricemic, gouty, and acute gouty arthritis cohorts. Further, we studied the correlation of p.Q141K allele and levels of pro-/anti-inflammatory cytokines. Coding regions of the ABCG2 gene were analyzed in 70 primary hyperuricemic, 182 gout patients, and 132 normouricemic individua

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KONATALAPALLI, RUKMINI M., ELENA LUMEZANU, JAMES S. JELINEK, MARK D. MURPHEY, HONG WANG, and ARTHUR WEINSTEIN. "Correlates of Axial Gout: A Cross-sectional Study." Journal of Rheumatology 39, no. 7 (2012): 1445–49. http://dx.doi.org/10.3899/jrheum.111517.

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Objective.A cross-sectional study was undertaken to determine the prevalence of axial gout in patients with established gouty arthritis and to analyze clinical, laboratory, and radiological correlations.Methods.Forty-eight subjects with a history of gouty arthritis (American College of Rheumatology criteria) for ≥ 3 years under poor control were included. Subjects underwent history, physical examination, laboratory testing, and imaging studies, including radiographs of the hands and feet and computerized tomography (CT) of the cervical and lumbar spines and sacroiliac joints (SIJ). Patients wi

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Muna, Naila, and Wiwiek Natalya. "Penerapan Tindakan Kompres Hangat Dalam Menurunkan Skala Nyeri Pada Penderita Gout Arthritis." Prosiding Seminar Nasional Kesehatan 1 (December 22, 2021): 1753–57. http://dx.doi.org/10.48144/prosiding.v1i.928.

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AbstractGouty Arthritis is a disease associated with an inborn errors of purine matabolism. Gout Arthritis occurs due to a buildup of uric acid that exceeds the normal limit in the joints. This can cause pain in gouty arthritis sufferers so giving warm compresses is necessary for gouty arthritis sufferers. This study was a descriptive case study aiming to describe the application of warm compresses in reducing pain scale in patirnts with Gouty Arthritis. A client assessment form, observation sheets, pain scales, WWZ (Warm Water Zak), and uric acid measurement kid were the instuments being used

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Tomaszuk, Sebastian, Karolina Wąsik, and Magda Wojtuś. "Nutritional factors in the prevention and treatment of gout." Quality in Sport 9, no. 2 (2023): 29–36. http://dx.doi.org/10.12775/qs.2023.09.02.004.

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Introduction and purpose: Despite the fact that effective urate lowering therapy and anti-inflammatory drugs for the treatment of gout are commonly available, there is considerable interest in novel treatment approaches. Gouty patients often have a multitude of comorbidities, which lead to concern over drug–drug interactions and medication adverse events. Thus, diet modifications are examined as a way of nonpharmacological treatment of gout. In this review, we explore the potential impact of nutritional factors on hyperuricemia and clinical gout outcomes. A search was conducted using PubMed an

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Wu, Chien-Hsing, Chih-Chao Yang, Hsueh-Wen Chang, et al. "Urinary Uromodulin/Creatinine Ratio as a Potential Clinical Biomarker for Chronic Kidney Disease Patients with Gout: A Pilot Study." Medical Principles and Practice 28, no. 3 (2019): 273–79. http://dx.doi.org/10.1159/000496844.

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Objective: Recent studies have reported that reduced excretion of urinary uromodulin is associated with renal tubular function and risks of progressive kidney disease. Gouty nephropathy is usually seen in patients with gout. Patients with chronic gouty nephropathy are characterized by the deposition of monosodium urate crystals primarily involving the collecting ducts in the medulla. We postulated that this correlation may be specific to gout and may serve as a useful biomarker for chronic kidney disease (CKD). Materials and Methods: A total of 114 Taiwanese patients diagnosed with gout (n = 7

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Singh, Yogendra, Pankaj Mishra, and Pushpendra Kannojia. "Analysis of animal models based on pre-clinical symptoms of gout." Journal of Drug Delivery and Therapeutics 12, no. 1 (2022): 181–84. http://dx.doi.org/10.22270/jddt.v12i1.5270.

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Gout is a type of arthritis, which is a group of related disorders caused by episodes of abnormal inflammation in the joints. It is a metabolic disease characterized by high levels of uric acid in the blood. Uric acid is the end product of purine metabolism and hyperuricemia is caused by abnormalities of purine metabolism. Hyperuricemia is a risk factor for gout, heart disease, high blood pressure (hypertension), diabetes, and acute and chronic kidney disease. This research may attract widespread interest to researchers focusing on the different types of crystalline arthritis. There are over 1

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Bai, Xueshan, Mingshu Sun, Yuwei He, et al. "Serum CA72-4 is specifically elevated in gout patients and predicts flares." Rheumatology 59, no. 10 (2020): 2872–80. http://dx.doi.org/10.1093/rheumatology/keaa046.

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Abstract Objectives Serum CA72-4 levels are elevated in some gout patients but this has not been comprehensively described. The present study profiled serum CA72-4 expression in gout patients and verified the hypothesis that CA72-4 is a predictor of future flares in a prospective gout cohort. Methods To profile CA72-4 expression, a cross-sectional study was conducted in subjects with gouty arthritis, asymptomatic hyperuricaemia, four major arthritis types (OA, RA, SpA, septic arthritis) and healthy controls. A prospective gout cohort study was initiated to test the value of CA72-4 for predicti

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Ahmad Zakiudin and Vicky Liza Nabila. "Penyuluhan Kesehatan Tentang Asam Urat Dan Pemberian Rebusan Daun Salam Untuk Mengurangi Kadar Asam Urat Di Desa Kalibuntu Kecamatan Losari Kabupaten Brebes." Bumi : Jurnal Hasil Kegiatan Sosialisasi Pengabdian kepada Masyarakat 2, no. 1 (2024): 141–46. http://dx.doi.org/10.61132/bumi.v2i1.53.

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Gouty arthritis is an autoimmune disease that occurs in 0.1-0.5% of the population and three-quarters of them are women. According to several researchers, the trigger factors for gout show that the interaction between environmental and genetic factors plays an important role. Genetic factors that play a role in the occurrence of gout arthritis and the severity of gout arthritis are smoking habits, silica inhalation, bacterial infections, viruses, mycobacteria and the hormone estrogen. The aim of this activity is to understand gout and administer bay leaf decoction to determine the efficacy of

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Bursill, David, William J. Taylor, Robert Terkeltaub, et al. "Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout." Annals of the Rheumatic Diseases 78, no. 11 (2019): 1592–600. http://dx.doi.org/10.1136/annrheumdis-2019-215933.

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ObjectiveThere is a lack of standardisation in the terminology used to describe gout. The aim of this project was to develop a consensus statement describing the recommended nomenclature for disease states of gout.MethodsA content analysis of gout-related articles from rheumatology and general internal medicine journals published over a 5-year period identified potential disease states and the labels commonly assigned to them. Based on these findings, experts in gout were invited to participate in a Delphi exercise and face-to-face consensus meeting to reach agreement on disease state labels a

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Fomin, Viktor V. "Gouty (urate) nephropathy." Consilium Medicum 23, no. 1 (2021): 11–14. http://dx.doi.org/10.26442/20751753.2021.1.200709.

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Clinical variants of kidney damage in gout including asymptomatic disorders of uric acid metabolism are discussed. The risk factor for hyperuricemia and associated kidney damage, clinical variants of gouty nephropathy and approaches to its treatment are presented. Keywords: gout, urate nephropathy, hyperuricemia, uric acid For citation: Fomin VV. Gouty (urate) nephropathy. Consilium Medicum. 2021; 23 (1): 11–14. DOI: 10.26442/20751753.2021.1.200709

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Lynn, Jeremy V., Amy L. Strong, and Kevin C. Chung. "Flexor Tendon Rupture Secondary to Gout." Archives of Plastic Surgery 50, no. 05 (2023): 492–95. http://dx.doi.org/10.1055/s-0043-1772756.

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AbstractExtra-articular deposition of monosodium urate crystals is a widely recognized manifestation of gout. However, gouty infiltration of flexor tendons in the hand resulting in tendon rupture is exceedingly rare. This case report highlights a patient with gouty infiltration of flexor tendons in the right middle finger resulting in rupture of both the flexor digitorum profundus and flexor digitorum superficialis. Given the extent of gouty infiltration and need for pulley reconstruction, the patient was treated with two-stage flexor tendon reconstruction. Febuxostat was prescribed preoperati

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Liu, Lei, Xiaoxia Zhu, Tianyi Zhao, Yiyun Yu, Yu Xue, and Hejian Zou. "Sirt1 ameliorates monosodium urate crystal–induced inflammation by altering macrophage polarization via the PI3K/Akt/STAT6 pathway." Rheumatology 58, no. 9 (2019): 1674–83. http://dx.doi.org/10.1093/rheumatology/kez165.

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Abstract Objectives Acute gout is an inflammatory response to MSU crystals. In our previous research, Sirt1 was shown to have an effect in preventing acute gouty inflammation. In the current study, we aimed to investigate the underlying mechanism involving Sirt1 in acute gout. Methods The cytological changes and Sirt1 expression in the synovium were observed in patients with acute or intermittent gout. The effect of Sirt1 and its mechanism in gout were studied in macrophages, C57BL/6 mice and Sirt1+/− mice. Results Sirt1 expression was increased in the peripheral blood mononuclear cells (PBMCs

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Straton, Ancuta R., Brenda Kischkel, Tania O. Crișan, and Leo A. B. Joosten. "Epigenomic Reprogramming in Gout." Gout, Urate, and Crystal Deposition Disease 2, no. 4 (2024): 325–38. http://dx.doi.org/10.3390/gucdd2040023.

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Gout is a crystal-induced arthropathy in which monosodium urate (MSU) crystals precipitate within joints as a result of persistent hyperuricemia and elicit an inflammatory response. An intriguing aspect is the occurrence of gout in only 10–15% of hyperuricemic individuals, suggesting the presence of additional risk factors. Although MSU crystal deposition is widely recognized as the cause of gout flares, the variability in initiating the inflammatory response to hyperuricemia and MSU deposition is not well understood. Several studies bring up-to-date information about the environmental and gen

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BOBIRCA, Anca, Cristina ALEXANDRU, Carmen IORGUS, et al. "Particularities of Patients Dignosed with Gout in Rheumatology Departament." Medicina Moderna - Modern Medicine 29, no. 4 (2022): 301–6. http://dx.doi.org/10.31689/rmm.2022.29.4.301.

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Gout is a chronic metabolic disease, characterized by joint inflammation caused by monosodium urate monohydrate crystals. The main objective of this study was to identify the prevalence of gout in a rheumatology department in Romania and secondary to describe the characteristics of patients diagnosed with this condition, with emphasis on the comorbidities. This is a longitudinal, retrospective study on 280 patients from the Department of Internal Medicine and Rheumatology, Dr I Cantacuzino Hospital, from January 2017 to May 2019, diagnosed with chronic or acute gout. The prevalence of gout in

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Radak-Perovic, Marija, and Mirjana Zlatkovic-Svenda. "Novelties in gout." Srpski arhiv za celokupno lekarstvo 141, no. 1-2 (2013): 109–15. http://dx.doi.org/10.2298/sarh1302109r.

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Chronic asymptomatic hyperuratemia (HUA), gout paroxysm in patients with chronic hyperuratemia (HU) and normouricemic attacks of gouty arthritis are well known, but poorly understood. A review of the current literature with attempt of its explanation is presented. The natural course of gout is associated with joint structure changes that may be evaluated by different imaging techniques; comparative advantages and shortcomings of each technique are presented. For almost over 50 years the market has not offered new drugs for the control of HU and gout, while management of such patients was a rat

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Wang, Yangang, Donghua Xu, Bin Wang, and Xu Hou. "Could MicroRNAs be Regulators of Gout Pathogenesis?" Cellular Physiology and Biochemistry 36, no. 6 (2015): 2085–92. http://dx.doi.org/10.1159/000430176.

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MicroRNAs (miRNAs) are a class of noncoding RNAs that mainly negatively regulate gene expression. miRNAs have important roles in many diseases, including inflammatory diseases. Gout is a common arthritis caused by deposition of monosodium urate crystals within joints. Recent studies suggested that miRNAs may be involved in the development of inflammatory arthritis, including acute gouty arthritis. In the present review, we systemically discuss relevant publications in order to provide a better understanding on the possible role of miRNAs in gout. miRNAs may act as regulators of gout pathogenes

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Mujaddid, Idulhaq, E. Rosihan, T. H. Handry, and W. Brian. "Tophaceous Gout of Hip Joint Mimicking Bone Tumor." Open Access Macedonian Journal of Medical Sciences 8, no. C (2020): 181–83. http://dx.doi.org/10.3889/oamjms.2020.4624.

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BACKGROUND: Gout is a condition characterized by abnormally elevated levels of uric crystals (gouty tophi). It is often to detect in the foot and ankle. Occasionally such tophus is found at rare sites and makes a challenge to the clinician where diagnosis and treatment are concerned. CASE REPORT: We present a patient who presented to our oncology department with pain on her right hip. It was diagnosed as a benign tumor by the clinical and radiological assessment but intraoperatively turned out to be gouty tophi. Excision surgery has performed, in the 1-year follow-up; there is no relapse

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Galozzi, Paola, Sara Bindoli, Andrea Doria, Francesca Oliviero, and Paolo Sfriso. "Autoinflammatory Features in Gouty Arthritis." Journal of Clinical Medicine 10, no. 9 (2021): 1880. http://dx.doi.org/10.3390/jcm10091880.

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In the panorama of inflammatory arthritis, gout is the most common and studied disease. It is known that hyperuricemia and monosodium urate (MSU) crystal-induced inflammation provoke crystal deposits in joints. However, since hyperuricemia alone is not sufficient to develop gout, molecular-genetic contributions are necessary to better clinically frame the disease. Herein, we review the autoinflammatory features of gout, from clinical challenges and differential diagnosis, to the autoinflammatory mechanisms, providing also emerging therapeutic options available for targeting the main inflammato

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Bardin, Thomas, Emmanuel Letavernier, and Jean-Michel Correas. "The Gouty Kidney: A Reappraisal." Gout, Urate, and Crystal Deposition Disease 1, no. 1 (2023): 25–36. http://dx.doi.org/10.3390/gucdd1010004.

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This review re-examines the role of crystal deposition in the kidney in view of recent clinical and experimental findings. The involvement of the renal system in gout seems frequent. Indeed, recent studies showed that approximately 25% of patients with gout experience renal failure, defined by estimated glomerular filtration rate <60 mL/min/1.73 m2. The pathophysiology is complex and involves several factors, their respective roles being difficult to dissect. The role of crystal deposition in the kidney was the first suspected, and the concept of gouty microcrystalline nephropathy, also cal

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Jiang, Xiaoyan, Anxin Li, Wei Hao, Cheng Yang, Hongyan Wang, and Wuquan Deng. "Limb salvage and systemic management of gouty tophi: Case series." Medicine 103, no. 20 (2024): e38137. http://dx.doi.org/10.1097/md.0000000000038137.

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Introduction: Gout is a chronic disease characterized by deposition of monosodium urate crystals. Tophi develop in some individuals with untreated or uncontrolled gout, which leads to ulcerations, cosmetic problems, mechanical obstruction of joint movement, joint damage and musculoskeletal disability. Currently, the treatment of gouty tophi is controversial and challenging. Both surgical and internal medical treatments have limitations and require further exploration in clinical practice. Patient concerns: In Case 1, we treated a patient with severe infection of diabetic foot ulcers with conco

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Fairhurst, Rick J., Arnold M. Schwartz, and Leo M. Rozmaryn. "Gouty Tenosynovitis of the Distal Biceps Tendon Insertion Complicated by Partial Rupture." HAND 12, no. 1 (2016): NP1—NP5. http://dx.doi.org/10.1177/1558944715627639.

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Background: Given the appreciable prevalence of gout, gout-induced tendon ruptures in the upper extremity are extremely rare. Although these events have been reported only 5 times in the literature, all in patients with a risk factor for or history of gout, they have conspicuously never been diagnosed in the shoulder or elbow. Methods: A 45-year-old, right-hand-dominant man with a history of gout presented with pain in his right anterior elbow and weakness in his forearm after a trivial injury. Results: Here, we report the first case of gouty tenosynovitis of the distal biceps tendon insertion

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Wang, Lu, Crystal Rose, Paul Mellen, George Branam, and Maria M. Picken. "Gouty Panniculitis with Ulcerations in a Patient with Multiple Organ Dysfunctions." Case Reports in Rheumatology 2014 (2014): 1–4. http://dx.doi.org/10.1155/2014/320940.

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Gouty panniculitis is a rare manifestation of gout. Clinically, it is characterized by indurated subcutaneous nodules in nonjoint areas. Pathologically, typical characteristic gouty tophi can be seen in subcutaneous tissue. It is postulated that gouty panniculitis develops as a consequence of uric acid accumulation in the body and localized inflammatory changes in subcutaneous tissue. We report a case of a 46-year-old man with 20-year history of gout, who developed multiple subcutaneous nodules over the abdomen and right groin/thigh area over a 2-year period. After a recent episode of congesti

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SAKETKOO, LESLEY A., IGNACIO GARCIA-VALLADARES, and LUIS R. ESPINOZA. "Axial Gout: Cinderella of Gouty Arthropathy!" Journal of Rheumatology 39, no. 7 (2012): 1314–16. http://dx.doi.org/10.3899/jrheum.120375.

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Flores Martín, José Francisco, Fernando Vázquez Alonso, Ignacio Puche Sanz, Raquel Berrio Campos, Miguel Angel Campaña Gutierrez, and José Manuel Cózar Olmo. "Gouty Tophi in the Penis: A Case Report and Review of the Literature." Case Reports in Urology 2012 (2012): 1–3. http://dx.doi.org/10.1155/2012/594905.

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Gout is a metabolic disease characterized by hyperuricemia and the deposition of monosodium urate crystals in different anatomical locations. We report the case of a 61-year-old man who received consultation for gouty tophi in the penis, which is an unusual location for this type of pathology, that was resolved with the surgical removal of the tophi. We provide a review on gout and its treatment as well as other locations where atypical gouty tophi have been described.

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Dwi Nurfajriyah, Airin Putri Aprilia, Elsyana Fadhilah, B. Tamas Arbania Efendi, Armatella Makdalena, and Sri Ariyanti. "Literature Review Asuhan Keperawatan Lansia pada Pasien Penderita Gout Arthritis." Jurnal Kajian dan Penelitian Umum 3, no. 1 (2025): 318–23. https://doi.org/10.47861/jkpu-nalanda.v3i1.1553.

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Background: Elderly (elderly) is not a disease but a life process characterized by a decrease in the body's ability. The elderly will continue to experience the aging process, causing some functions and metabolism in the body to decrease. One metabolic disorder that is often experienced by the elderly is Gout Arthritis or gout. Gouty arthritis or gout is usually characterized by acute joint inflammation caused by the formation of crystallized uric acid. This gouty arthritis disease arises because of consuming too much food and drinks containing purines, including tea, coffee, offal (tripe, spl

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SCHLESINGER, NAOMI, JOSEPHINE M. NORQUIST, and DOUGLAS J. WATSON. "Serum Urate During Acute Gout." Journal of Rheumatology 36, no. 6 (2009): 1287–89. http://dx.doi.org/10.3899/jrheum.080938.

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Objective.To study the frequency of normal serum urate (SU) levels during acute gout in the largest studies of acute gout treatment to date.Methods.Data collected from 2 randomized controlled clinical trials assessing the efficacy of etoricoxib or indomethacin for 7 days in acute gout were used to assess SU levels during acute gouty attacks. Efficacy was similar with both agents, so both groups were combined for analysis.Results.A total of 339 patients were enrolled in the 2 studies; 94% were male; mean age was 50.5 years. At baseline, 14% of patients had a “true” normal SU (≤ 6 mg/dl) and 32%

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Lee, Hye Eun, Gabsik Yang, Youn Bum Park, et al. "Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis." Molecules 24, no. 11 (2019): 2138. http://dx.doi.org/10.3390/molecules24112138.

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Gout is a chronic inflammatory disease evoked by the deposition of monosodium urate (MSU) crystals in joint tissues. The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome is responsible for the gout inflammatory symptoms induced by MSU crystals. We investigated whether epigallocatechin-3-gallate (EGCG) suppresses the activation of the NLRP3 inflammasome, thereby effectively preventing gouty inflammation. EGCG blocked MSU crystal-induced production of caspase-1(p10) and interleukin-1β in primary mouse macrophages, indicatin

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Goldberg, Emily Lauren, Jennifer L. Asher, Ryan Molony та ін. "β-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares". Journal of Immunology 198, № 1_Supplement (2017): 206.18. http://dx.doi.org/10.4049/jimmunol.198.supp.206.18.

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Abstract Aging and lipotoxicity are two major risk factors for gout that are linked by the activation of the NLRP3 inflammasome. IL-1β produced by macrophages and neutrophils drives gouty flares that cause joint destruction, intense pain and fever. Small clinical trials have reported that IL-1R antagonists reduced pain in gout patients, but these biologicals are expensive and may compromise immune responses. Moreover, current treatment strategies for gout are limited in efficacy and do not specifically target the NLRP3 inflammasome. NLRP3 activation is regulated by numerous metabolic byproduct

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Xi, Shijun, ZhiguoShao, Lu Li, et al. "Tongbixiao Pills Improve Gout by Reducing Uric Acid Levels and Inhibiting Inflammation." Dose-Response 20, no. 2 (2022): 155932582210903. http://dx.doi.org/10.1177/15593258221090340.

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Gout is a chronic disease. Gout symptoms are often experienced in the middle of the night. The onset of gout in the middle of the night is closely related to abnormal liver and gallbladder meridian. The purpose of this study was to investigate the clinical efficacy and possible mechanism of action of Tongbixiao pills in the treatment of hyperuricemia and gouty arthritis. The Tongbixiao pills we used included several traditional Chinese medicines, most of which tonify the spleen; strengthen the liver; benefit the kidney; and reduce heat, dampness, and blood stasis. In this randomized clinical s

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Stern, L., R. Johnson, P. Shakouri, et al. "AB1050 CHARACTERISTICS OF PATIENTS WITH COINCIDENT GOUT AND ADVANCED CHRONIC KIDNEY DISEASE." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1647.2–1648. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2489.

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BackgroundPatients with chronic kidney disease (CKD) are at increased risk for developing gout1 and vice versa.2 Those with both gout and CKD present distinct challenges for patients and physicians because of the high prevalence of other comorbidities and restrictions on gout medication use, including non-steroidal anti-inflammatories3,4 and some oral urate-lowering therapies (ULTs).5 This unique patient population has not been well characterized using real-world data.ObjectivesThis retrospective chart review study of patients with coincident gout and CKD was conducted to better understand pat

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Saliba, Joe, Hitomi Sakano, Rick A. Friedman, and Jeffrey P. Harris. "Tophaceous Gout of the Middle Ear: Case Reports and Review of the Literature." Audiology and Neurotology 24, no. 2 (2019): 51–55. http://dx.doi.org/10.1159/000500514.

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Tophaceous gout of the middle ear is a rare occurrence that presents as a granular white-colored mass. It is frequently misdiagnosed as cholesteatoma or tympanosclerosis in patients who otherwise may not manifest any clinical or biochemical signs of gout. While uncommon, it can lead to clinically significant disease such as conductive hearing loss. The present report describes 2 cases of middle ear gouty tophi initially mistaken for another entity. Both patients underwent surgery, and the diagnosis of gout was revealed after final histopathological analysis. A review of the literature is also

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Akhter, Asad S., Ahmed Mohyeldin, and Andrew J. Grossbach. "Acute presentation of spinal gouty arthritis: A case report and review of literature." Surgical Neurology International 10 (November 29, 2019): 232. http://dx.doi.org/10.25259/sni_528_2019.

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Background: Gout is an inflammatory arthritis that results from faulty purine metabolism, affecting approximately 4% of adults in the US, and predominately affects people in the fourth decade of life. Further, spinal gout is rarely the first presentation of gout, especially in younger individuals. Case Description: A 26-year-old male came to the emergency room with acute lower extremity numbness and weakness. The MR demonstrated an enhancing epidural lesion at T6–T8 in the mid-thoracic spine. He subsequently underwent a decompressive laminectomy and fusion at levels T6–T9, resulting in full re

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Polukhina, E. V. "Musculoskeletal ultrasound in gout." Ultrasound & Functional Diagnostics, no. 2 (December 22, 2023): 62–79. http://dx.doi.org/10.24835/1607-0771-2023-2-62-79.

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The article presents a pictorial literature review on musculoskeletal ultrasound in gout, which is the most common cause of inflammatory arthropathy in adults. Nowadays, among imaging modalities, ultrasound provides the best capabilities for gout diagnosing and monitoring by revealing of monosodium urate deposits in various joint structures, assessing the presence and severity of synovial inflammation, including for dynamical evaluation on urate-lowering therapy. The main ultrasound features of gout (double contour sign, tophi, aggregates and erosions) are described according to the current cl

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Cao, Ling, Tianyi Zhao, Chunmei Xie, et al. "Performance of Ultrasound in the Clinical Evaluation of Gout and Hyperuricemia." Journal of Immunology Research 2021 (April 5, 2021): 1–7. http://dx.doi.org/10.1155/2021/5550626.

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Objective. To evaluate monosodium urate (MSU) crystal deposition and related lesions in the joints of patients with gout and hyperuricemia (HUA) using ultrasound. To explore the association between ultrasound findings and clinical features in gout and HUA. Methods. A total of 202 patients with gout and 43 asymptomatic patients with HUA were included. The clinical data and ultrasonic assessment results were collected and statistically analyzed. Results. Deposition of MSU crystals was found in 25.58% (11/43) of patients with asymptomatic HUA and 76.24% (154/202) of patients with gout. Of the 1,0

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Tajika, Tsuyoshi, Takuro Kuboi, Tokue Mieda, et al. "Digital flexion contracture caused by tophaceous gout in flexor tendon." SAGE Open Medical Case Reports 7 (January 2019): 2050313X1984470. http://dx.doi.org/10.1177/2050313x19844708.

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Gouty tophus is an unusual cause of digital flexion contracture. Awareness of this pathophysiology will lead to more confidence in proper treatment and surgical management of this rare condition. This report describes a case of digital flexion contracture by tophaceous gout distinguished between trigger finger and locking of the metacarpophalangeal joint. We found the flexor tendon with a deposited chalky white substance suggestive of gouty tophus intraoperatively. We performed tenosynovectomy and removed the chalky white substance to the greatest degree possible. Histological findings confirm

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Sheng, Tan Shong, and Kyi Kyi Win. "Gluteal abscess caused by infected gouty panniculitis: a case report on sequalae of uncontrolled gout." Ethiopian Medical Journal 62, no. 3 (2024): 229–32. http://dx.doi.org/10.4314/emj.v62i3.11.

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Gouty panniculitis is uncommon manifestation of gout associated with monosodium urate (MSU) deposition into subcutaneous tissue. We report our local experience of this disease and its management strategy. Our patient was 39 years old gentleman, known to have gout who had not been compliant to follow up, presented with bilateral gluteal swellings for one month associated with discharge from the left gluteal swelling for 2 days. Clinical diagnosis of gluteal abscess with suspected infected gouty tophi was made. Wound debridement of infected left gluteal swelling was performed, followed by short

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