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Journal articles on the topic 'GP90 lymphocyte homing/adhesion receptor'

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Published: 4 June 2025

Last updated: 1 August 2025

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1

Mobley, J. L., and M. O. Dailey. "Regulation of adhesion molecule expression by CD8 T cells in vivo. I. Differential regulation of gp90MEL-14 (LECAM-1), Pgp-1, LFA-1, and VLA-4 alpha during the differentiation of cytotoxic T lymphocytes induced by allografts." Journal of Immunology 148, no. 8 (1992): 2348–56. http://dx.doi.org/10.4049/jimmunol.148.8.2348.

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Abstract A variety of adhesion molecules regulate the traffic and tissue localization of lymphocytes in vivo by mediating their binding to vascular endothelial cells. The homing receptor gp90MEL-14 (gp90), also known as LECAM-1 or L-selectin, mediates the adhesion of lymphocytes to specialized high endothelial venules in lymph nodes (LN) and is the primary molecule regulating lymphocyte recirculation and homing to LN, whereas other adhesion molecules have a major role in the localization of lymphocytes in inflammatory sites. We used four-color flow cytometric analysis to examine the regulation

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2

Pals, S. T., F. Hogervorst, G. D. Keizer, T. Thepen, E. Horst, and C. C. Figdor. "Identification of a widely distributed 90-kDa glycoprotein that is homologous to the Hermes-1 human lymphocyte homing receptor." Journal of Immunology 143, no. 3 (1989): 851–57. http://dx.doi.org/10.4049/jimmunol.143.3.851.

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Abstract Homing of recirculating lymphocytes from the blood into the lymphoid tissues is mediated by 90-kDa homing receptors on the lymphocyte cell surface, allowing selective binding to specialized endothelium lining high endothelial venules. This study describes two novel mAb, NKI-P1 and NKI-P2, directed against functional epitopes of a human lymphocyte homing receptor, gp90. Biochemical studies demonstrated that these antibodies recognize a 90-kDa glycoprotein which is similar to the Ag recognized by the mAb Hermes-1. This notion was confirmed by immunohistochemical studies showing identica

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3

Jung, T. M., and M. O. Dailey. "Rapid modulation of homing receptors (gp90MEL-14) induced by activators of protein kinase C. Receptor shedding due to accelerated proteolytic cleavage at the cell surface." Journal of Immunology 144, no. 8 (1990): 3130–36. http://dx.doi.org/10.4049/jimmunol.144.8.3130.

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Abstract Lymphocyte entry into lymph nodes and Peyer's patches is initiated by the adhesion of the lymphocytes to specialized postcapillary high endothelial venules (HEV). The binding of lymphocytes to lymph node HEV is mediated by the cell surface receptor gp90MEL-14 (gp90). Previous work has shown that gp90 is down-regulated over a period of days after mitogenic or mixed lymphocyte reaction stimulation of T lymphocytes. In our study, it is shown that stimulation of lymphocytes with activators of protein kinase C (PKC), such as PMA or 1-oleoyl 2-acetyl-glycerol, results in the nearly complete

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4

Hamann, A., D. Jablonski-Westrich, A. Duijvestijn, et al. "Evidence for an accessory role of LFA-1 in lymphocyte-high endothelium interaction during homing." Journal of Immunology 140, no. 3 (1988): 693–99. http://dx.doi.org/10.4049/jimmunol.140.3.693.

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Abstract In a variety of lymphocyte interactions, lymphocyte function-associated antigen-1 (LFA-1) plays an important role as an accessory mechanism mediating cell adhesion. We tested the possibility that LFA-1 could also be involved in the specific binding of lymphocytes to high endothelial venules (HEV) during homing. Antibodies against LFA-1 but not against various other cell surface molecules (except the putative gp90 homing receptor defined by the MEL-14 antibody) were found to inhibit in vitro adherence of lymphocytes to HEV in frozen sections of lymph nodes. Binding of T cell lines to H

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5

Bowen, B. R., T. Nguyen, and L. A. Lasky. "Characterization of a human homologue of the murine peripheral lymph node homing receptor." Journal of Cell Biology 109, no. 1 (1989): 421–27. http://dx.doi.org/10.1083/jcb.109.1.421.

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Lymphocyte trafficking is a fundamental aspect of the immune system that allows B and T lymphocytes with diverse antigen recognition specificities to be exposed to various antigenic stimuli in spatially distinct regions of an organism. A lymphocyte adhesion molecule that is involved with this trafficking phenomenon has been termed the homing receptor. Previous work (Lasky, L., T. Yednock, M. Singer, D. Dowbenko, C. Fennie, H. Rodriguez, T. Nguyen, S. Stachel, and S. Rosen. 1989. Cell. 56:1045-1055) has characterized a cDNA clone encoding a murine homing receptor that is involved in trafficking

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6

Imai, Y., M. S. Singer, C. Fennie, L. A. Lasky, and S. D. Rosen. "Identification of a carbohydrate-based endothelial ligand for a lymphocyte homing receptor." Journal of Cell Biology 113, no. 5 (1991): 1213–21. http://dx.doi.org/10.1083/jcb.113.5.1213.

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Lymphocyte attachment to high endothelial venules within lymph nodes is mediated by the peripheral lymph node homing receptor (pnHR), originally defined on mouse lymphocytes by the MEL-14 mAb. The pnHR is a calcium-dependent lectin-like receptor, a member of the LEC-CAM family of adhesion proteins. Here, using a soluble recombinant form of the homing receptor, we have identified an endothelial ligand for the pnHR as an approximately 50-kD sulfated, fucosylated, and sialylated glycoprotein, which we designate Sgp50 (sulfated glycoprotein of 50 kD). Recombinant receptor binding to this lymph nod

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7

Geoffroy, J. S., and S. D. Rosen. "Demonstration that a lectin-like receptor (gp90MEL) directly mediates adhesion of lymphocytes to high endothelial venules of lymph nodes." Journal of Cell Biology 109, no. 5 (1989): 2463–69. http://dx.doi.org/10.1083/jcb.109.5.2463.

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Lymphocyte migration from the blood into most secondary lymphoid organs is initiated by a highly selective adhesive interaction with the endothelium of specialized blood vessels known as high endothelial venules (HEV). The propensity of lymphocytes to migrate to particular lymphoid organs is known as lymphocyte homing, and the receptors on lymphocytes that dictate interactions with HEV at particular anatomical sites are designated "homing receptors". Based upon antibody blockade experiments and cell-type distribution studies, a prominent candidate for the peripheral lymph node homing receptor

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8

Zhou, D. F., J. F. Ding, L. J. Picker, R. F. Bargatze, E. C. Butcher, and D. V. Goeddel. "Molecular cloning and expression of Pgp-1. The mouse homolog of the human H-CAM (Hermes) lymphocyte homing receptor." Journal of Immunology 143, no. 10 (1989): 3390–95. http://dx.doi.org/10.4049/jimmunol.143.10.3390.

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Abstract Mouse phagocytic glycoprotein-1 (Pgp-1; Ly-24) is a 95-kDa glycoprotein of unknown function that has served as an important T cell/leukocyte differentiation marker. Recent work has suggested that it may be related to a human 85- to 95-kDa glycoprotein (termed variously the Hermes Ag/lymphocyte homing receptor, ECMRIII, P80, and CD44) that is involved in lymphocyte binding to high endothelial venules in the process of lymphocyte homing, and has been implicated in other cell adhesion events. The widespread expression of this molecular class in diverse organ systems suggests a broad role

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9

Brown, T. A., T. Bouchard, T. St John, E. Wayner, and W. G. Carter. "Human keratinocytes express a new CD44 core protein (CD44E) as a heparan-sulfate intrinsic membrane proteoglycan with additional exons." Journal of Cell Biology 113, no. 1 (1991): 207–21. http://dx.doi.org/10.1083/jcb.113.1.207.

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We previously identified a 90-kD (GP90), collagen-binding, membrane glycoprotein, termed extracellular matrix receptor III (ECMR III), that is homologous to the lymphocyte homing receptor and CD44 antigen (Gallatin, W. M., E. A. Wayner, P. A. Hoffman, T. St. John, E. C. Butcher, and W. G. Carter. 1989. Proc. Natl. Acad. Sci. USA. 86:4654-4658). CD44 is abundantly expressed in many epithelial tissues, and is localized predominantly to filopodia in cultured keratinocytes. Here we establish CD44 as a polymorphic family of related membrane proteoglycans and glycoproteins possessing extensive diver

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10

Berlin-Rufenach, Cornelia, Florian Otto, Meg Mathies, et al. "Lymphocyte Migration in Lymphocyte Function-associated Antigen (LFA)-1–deficient Mice." Journal of Experimental Medicine 189, no. 9 (1999): 1467–78. http://dx.doi.org/10.1084/jem.189.9.1467.

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Using lymphocyte function-associated antigen (LFA)-1−/− mice, we have examined the role of LFA-1 and other integrins in the recirculation of lymphocytes. LFA-1 has a key role in migration to peripheral lymph nodes (pLNs), and influences migration into other LNs. Second, the α4 integrins, α4β7 and α4β1, have a hitherto unrecognized ability to compensate for the lack of LFA-1 in migration to pLNs. These findings are confirmed using normal mice and blocking LFA-1 and α4 monoclonal antibodies. Unexpectedly, vascular cell adhesion molecule (VCAM)-1, which is essential in inflammatory responses, ser

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11

Tedder, T. F., C. M. Isaacs, T. J. Ernst, G. D. Demetri, D. A. Adler, and C. M. Disteche. "Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins." Journal of Experimental Medicine 170, no. 1 (1989): 123–33. http://dx.doi.org/10.1084/jem.170.1.123.

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A cDNA encoding a new human lymphocyte cell surface molecule has been isolated and shown to identify a fourth member of a recently discovered family of adhesion proteins. This lymphocyte-associated molecule (LAM-1) is uniquely composed of multiple distinct domains, one domain homologous with animal lectins, one homologous with epidermal growth factor, and two short consensus repeat units similar to those found in C3/C4 binding proteins. This cDNA clone hybridized with RNAs found in B cell lines and T lymphocytes, but not with RNA from other cell types. The amino acid sequence of LAM-1 is 77% h

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12

Mountz, J. D., W. C. Gause, F. D. Finkelman, and A. D. Steinberg. "Prevention of lymphadenopathy in MRL-lpr/lpr mice by blocking peripheral lymph node homing with Mel-14 in vivo." Journal of Immunology 140, no. 9 (1988): 2943–49. http://dx.doi.org/10.4049/jimmunol.140.9.2943.

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Abstract MRL-lpr/lpr mice develop massive lymphadenopathy and autoimmunity. There is evidence that both migration and local proliferation contribute to the accumulation of Ly-2-, L3T4-, 6B2+ T cells in the peripheral lymph node (PLN). Mel-14 is an antibody which binds to the lymphocyte lymph node homing receptor (gp90Mel-14) and can block migration of lymphocytes to the PLN. Treatment of mice from birth to 11 wk of age with Mel-14 and another rat IgG2a mAb, 6B2, resulted in reduction (10- to 20-fold) in lymphadenopathy. Mel-14, but not 6B2, preferentially reduced the percentages of Thy-1+, 6B2

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13

Bargatze, R. F., and E. C. Butcher. "Rapid G protein-regulated activation event involved in lymphocyte binding to high endothelial venules." Journal of Experimental Medicine 178, no. 1 (1993): 367–72. http://dx.doi.org/10.1084/jem.178.1.367.

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The homing of blood borne lymphocytes into lymph nodes and Peyer's patches is mediated in part by recognition and binding to specialized high endothelial venules (HEV). Here we demonstrate that a rapid pertussis toxin-sensitive lymphocyte activation event can participate in lymphocyte recognition of HEV. In situ video microscopic analyses of lymphocyte interactions with HEV in exteriorized mouse Peyer's patches reveal that pertussis toxin has no effect on an initial "rolling" displayed by many lymphocytes, but inhibits an activation-dependent "sticking" event required for lymphocyte arrest. Th

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14

Mebius, R. E., P. R. Streeter, J. Brevé, A. M. Duijvestijn, and G. Kraal. "The influence of afferent lymphatic vessel interruption on vascular addressin expression." Journal of Cell Biology 115, no. 1 (1991): 85–95. http://dx.doi.org/10.1083/jcb.115.1.85.

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Tissue-selective lymphocyte homing is directed in part by specialized vessels that define sites of lymphocyte exit from the blood. These vessels, the post capillary high endothelial venules (HEV), are found in organized lymphoid tissues, and at sites of chronic inflammation. Lymphocytes bearing specific receptors, called homing receptors, recognize and adhere to their putative ligands on high endothelial cells, the vascular addressins. After adhesion, lymphocytes enter organized lymphoid tissues by migrating through the endothelial cell wall. Cells and/or soluble factors arriving in lymph node

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15

Lewinsohn, DM, A. Nagler, N. Ginzton, P. Greenberg, and EC Butcher. "Hematopoietic progenitor cell expression of the H-CAM (CD44) homing- associated adhesion molecule." Blood 75, no. 3 (1990): 589–95. http://dx.doi.org/10.1182/blood.v75.3.589.589.

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Abstract We explored the expression of a lymphocyte homing-associated cell adhesion molecule (H-CAM, CD44) on hematopoietic progenitors. We demonstrate that immature myeloid and erythroid leukemic cell lines stain intensely with monoclonal antibodies Hermes-1 and Hermes-3, which define distinct epitopes on lymphocyte surface H-CAM, a glycoprotein involved in lymphocyte interactions with endothelial cells. Using fluorescence-activated cell sorting (FACS), human marrow cells were fractionated into Hermeshi, Hermesmed, and Hermeslo populations according to the expression of both the Hermes-1 and

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16

Lewinsohn, DM, A. Nagler, N. Ginzton, P. Greenberg, and EC Butcher. "Hematopoietic progenitor cell expression of the H-CAM (CD44) homing- associated adhesion molecule." Blood 75, no. 3 (1990): 589–95. http://dx.doi.org/10.1182/blood.v75.3.589.bloodjournal753589.

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We explored the expression of a lymphocyte homing-associated cell adhesion molecule (H-CAM, CD44) on hematopoietic progenitors. We demonstrate that immature myeloid and erythroid leukemic cell lines stain intensely with monoclonal antibodies Hermes-1 and Hermes-3, which define distinct epitopes on lymphocyte surface H-CAM, a glycoprotein involved in lymphocyte interactions with endothelial cells. Using fluorescence-activated cell sorting (FACS), human marrow cells were fractionated into Hermeshi, Hermesmed, and Hermeslo populations according to the expression of both the Hermes-1 and Hermes-3

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17

Steen, P. D., J. R. McGregor, C. M. Lehman, and W. E. Samlowski. "Changes in homing receptor expression on murine lymphokine-activated killer cells during IL-2 exposure." Journal of Immunology 143, no. 12 (1989): 4324–30. http://dx.doi.org/10.4049/jimmunol.143.12.4324.

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Abstract The effects of IL-2 on the expression of homing receptors by lymphocytes of NK or lymphokine activated killer (LAK) cell derivation has not yet been evaluated. We developed a murine model to evaluate the potential of LAK cells to localize into peripheral lymph nodes since LAK cells are used to treat human cancers which have metastasized to these tissues. Using a frozen section binding assay, LAK cell adhesion to the lymph node microvasculature was easily demonstrable. Inhibition studies demonstrated that LAK cell binding to lymph nodes was mediated by mechanisms previously described i

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18

Abitorabi, M. A., C. R. Mackay, E. H. Jerome, O. Osorio, E. C. Butcher, and D. J. Erle. "Differential expression of homing molecules on recirculating lymphocytes from sheep gut, peripheral, and lung lymph." Journal of Immunology 156, no. 9 (1996): 3111–17. http://dx.doi.org/10.4049/jimmunol.156.9.3111.

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Abstract The adhesion molecules integrin alpha 4 beta 7 and L-selectin have been hypothesized to help direct selective migration (homing) of lymphocytes to the gut and peripheral lymph nodes, respectively. An important prediction of current models is that lymphocytes selectively recirculating through an organ will preferentially express adhesion receptors for organ-specific endothelial ligands. To test this prediction, we directly examined the expression of cell adhesion molecules on lymphocytes recirculating through the gut, the periphery, and the lung. Integrin beta 7 was highly expressed on

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Stein, Jens V., Silvia F. Soriano, Christine M'rini, et al. "CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway." Blood 101, no. 1 (2003): 38–44. http://dx.doi.org/10.1182/blood-2002-03-0841.

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Abstract Homing of blood-borne lymphocytes to peripheral lymph nodes (PLNs) is a multistep process dependent on the sequential engagement of L-selectin, which mediates lymphocyte rolling along the luminal surface of high endothelial venules (HEVs), followed by activation of lymphocyte integrins and transmigration through HEVs. Within lymphoid tissue, B and T lymphocytes then migrate toward specific microenvironments such as B-cell follicles and the paracortex, respectively. The lymphocyte-expressed chemokine receptor CCR7 is playing an important role during this process, as its HEV-presented l

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Berg, E. L., T. Yoshino, L. S. Rott, et al. "The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1." Journal of Experimental Medicine 174, no. 6 (1991): 1461–66. http://dx.doi.org/10.1084/jem.174.6.1461.

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A skin-associated population of memory T lymphocytes, defined by expression of the cutaneous lymphocyte antigen (CLA), binds selectively and avidly to the vascular lectin endothelial cell-leukocyte adhesion molecule 1 (ELAM-1), an interaction that may be involved in targeting of CLA+ T cells to cutaneous sites of chronic inflammation. Here we present evidence that CLA itself is the (or a) lymphocyte homing receptor for ELAM-1. Antigen isolated with anti-CLA monoclonal antibody HECA-452 from human tonsillar lysates avidly binds ELAM-1 transfected mouse cells. Anti-CLA antibody blocks T lymphocy

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Kliche, Stefanie, Tim Worbs, Xiaoqian Wang, et al. "CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules." Blood 119, no. 3 (2012): 777–85. http://dx.doi.org/10.1182/blood-2011-06-362269.

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Abstract The β2-integrin lymphocyte function-associated antigen-1 (LFA-1) plays a crucial role within the immune system. It regulates the interaction between T cells and antigen-presenting cells and facilitates T-cell adhesion to the endothelium, a process that is important for lymphocyte extravasation and homing. Signals mediated via the T-cell receptor and the chemokine receptor CCR7 activate LFA-1 through processes known as inside-out signaling. The molecular mechanisms underlying inside-out signaling are not completely understood. Here, we have assessed the role of the ADAP/SKAP55 module f

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Hawkins, Raymond A., Roger G. Rank та Kathleen A. Kelly. "Expression of Mucosal Homing Receptor α4β7 Is Associated with Enhanced Migration to theChlamydia-Infected Murine Genital Mucosa In Vivo". Infection and Immunity 68, № 10 (2000): 5587–94. http://dx.doi.org/10.1128/iai.68.10.5587-5594.2000.

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ABSTRACT The CD4 T helper cell type 1 (Th1) response is essential for the resolution of chlamydial genital infection in mice. However, not all Th1 clones are equally protective in eradicating the infection. Since oral immunization regimens produce protective immunity, we evaluated the role of the mucosa-associated homing receptor, α4β7, in trafficking to the genital mucosa. Using a panel of CD4, Th1 cell lines and clones, we compared the lymphocyte homing patterns of aChlamydia-specific, protective clone (P-MoPn), a nonprotective clone (N-MoPn), and a keyhole limpet hemocyanin (KLH)-specific c

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23

Yednock, T. A., E. C. Butcher, L. M. Stoolman, and S. D. Rosen. "Receptors involved in lymphocyte homing: relationship between a carbohydrate-binding receptor and the MEL-14 antigen." Journal of Cell Biology 104, no. 3 (1987): 725–31. http://dx.doi.org/10.1083/jcb.104.3.725.

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Blood-borne lymphocytes extravasate in large numbers within peripheral lymph nodes (PN) and other secondary lymphoid organs. It has been proposed that the initiation of extravasation is based upon a family of cell adhesion molecules (homing receptors) that mediate lymphocyte attachment to specialized high endothelial venules (HEV) within the lymphoid tissues. A putative homing receptor has been identified by the monoclonal antibody, MEL-14, which recognizes an 80-90-kD glycoprotein on the surface of mouse lymphocytes and blocks the attachment of lymphocytes to PN HEV. In a companion study we c

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Bednarczyk, J. L., and B. W. McIntyre. "A monoclonal antibody to VLA-4 alpha-chain (CDw49d) induces homotypic lymphocyte aggregation." Journal of Immunology 144, no. 3 (1990): 777–84. http://dx.doi.org/10.4049/jimmunol.144.3.777.

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Abstract The complex processes of cellular adhesion involve a variety of receptor to ligand interactions that are extremely important during the development of immune function. Lymphocyte activation by Ag or mitogen, CTL- and NK-mediated cytolysis, homing to lymphoid-associated tissue, and the attachment of lymphocytes to extracellular matrix proteins are all governed, at least in part, by cell surface adhesion receptors. During the analysis of mAb for the ability to block human cytotoxic T lymphocyte-mediated killing an inhibitory mAb was noted that caused rapid and vigorous aggregation among

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Pals, ST, E. Horst, GJ Ossekoppele, CG Figdor, RJ Scheper, and CJ Meijer. "Expression of lymphocyte homing receptor as a mechanism of dissemination in non-Hodgkin's lymphoma." Blood 73, no. 4 (1989): 885–88. http://dx.doi.org/10.1182/blood.v73.4.885.885.

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Abstract To investigate whether the lymphocyte homing receptor (LHR), an adhesion molecule believed to play an important role in the control of normal lymphocyte circulation, influences the spread of non-Hodgkin's lymphoma (NHL), expression of LHR was examined in 107 NHL of various histologic and immunophenotypic subclasses. This analysis revealed that whereas NHL with a putative derivation from recirculating mature T and B lymphocytes almost invariably express high levels of LHR, those akin to sessile mature or immature lymphocytes tend to express lower levels of LHR. Furthermore, in a survey

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Pals, ST, E. Horst, GJ Ossekoppele, CG Figdor, RJ Scheper, and CJ Meijer. "Expression of lymphocyte homing receptor as a mechanism of dissemination in non-Hodgkin's lymphoma." Blood 73, no. 4 (1989): 885–88. http://dx.doi.org/10.1182/blood.v73.4.885.bloodjournal734885.

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To investigate whether the lymphocyte homing receptor (LHR), an adhesion molecule believed to play an important role in the control of normal lymphocyte circulation, influences the spread of non-Hodgkin's lymphoma (NHL), expression of LHR was examined in 107 NHL of various histologic and immunophenotypic subclasses. This analysis revealed that whereas NHL with a putative derivation from recirculating mature T and B lymphocytes almost invariably express high levels of LHR, those akin to sessile mature or immature lymphocytes tend to express lower levels of LHR. Furthermore, in a survey among di

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de los Toyos, J., S. Jalkanen, and EC Butcher. "Flow cytometric analysis of the Hermes homing-associated antigen on human lymphocyte subsets." Blood 74, no. 2 (1989): 751–60. http://dx.doi.org/10.1182/blood.v74.2.751.751.

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Abstract The homing of lymphocytes is controlled by interactions with high endothelial venules (HEV), specialized vessels that define sites of lymphocyte extravasation into lymph nodes and inflamed tissues. In humans, lymphocyte-HEV binding involves a lymphocyte surface glycoprotein (GP) of 85 to 95 kd (CD44, H-CAM), defined by monoclonal antibody (MoAb) Hermes-1. To define the expression of this homing- associated adhesion molecule during human lymphocyte development, we performed two-color immunofluorescence analyses of human bone marrow (BM), thymus, peripheral blood (PB), and tonsillar lym

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de los Toyos, J., S. Jalkanen, and EC Butcher. "Flow cytometric analysis of the Hermes homing-associated antigen on human lymphocyte subsets." Blood 74, no. 2 (1989): 751–60. http://dx.doi.org/10.1182/blood.v74.2.751.bloodjournal742751.

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The homing of lymphocytes is controlled by interactions with high endothelial venules (HEV), specialized vessels that define sites of lymphocyte extravasation into lymph nodes and inflamed tissues. In humans, lymphocyte-HEV binding involves a lymphocyte surface glycoprotein (GP) of 85 to 95 kd (CD44, H-CAM), defined by monoclonal antibody (MoAb) Hermes-1. To define the expression of this homing- associated adhesion molecule during human lymphocyte development, we performed two-color immunofluorescence analyses of human bone marrow (BM), thymus, peripheral blood (PB), and tonsillar lymphocytes.

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Campbell, James J., Edward P. Bowman, Kristine Murphy та ін. "6-C-kine (SLC), a Lymphocyte Adhesion-triggering Chemokine Expressed by High Endothelium, Is an Agonist for the MIP-3β Receptor CCR7". Journal of Cell Biology 141, № 4 (1998): 1053–59. http://dx.doi.org/10.1083/jcb.141.4.1053.

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The β chemokine known as 6-C-kine, secondary lymphoid-tissue chemokine (SLC), TCA4, or Exodus-2 (herein referred to as 6CK/SLC) can trigger rapid integrin-dependent arrest of lymphocytes rolling under physiological shear and is highly expressed by high endothelial venules, specialized vessels involved in lymphocyte homing from the blood into lymph nodes and Peyer's patches. We show that 6CK/SLC is an agonist for the lymphocyte chemoattractant receptor, CCR7 (EBI-1, BLR-2), previously described as a receptor for the related β chemokine MIP-3β (ELC or Exodus-3). Moreover, 6CK/SLC and MIP-3β attr

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Baekkevold, Espen S., Takeshi Yamanaka, Roger T. Palframan, et al. "The Ccr7 Ligand ELC (Ccl19) Is Transcytosed in High Endothelial Venules and Mediates T Cell Recruitment." Journal of Experimental Medicine 193, no. 9 (2001): 1105–12. http://dx.doi.org/10.1084/jem.193.9.1105.

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Lymphocyte homing to secondary lymphoid tissue is defined by a multistep sequence of interactions between lymphocytes and endothelial cells in high endothelial venules (HEVs). After initial selectin-mediated tethering and rolling, firm adhesion of lymphocytes requires rapid upregulation of lymphocyte integrin adhesiveness. This step is mediated in part by the HEV-derived chemokine SLC (secondary lymphoid-tissue chemokine, or CCL21) that binds to the CC chemokine receptor (CCR)7 on lymphocytes. However, the CC chemokine ELC (Epstein-Barr virus–induced molecule 1 ligand chemokine, or CCL19) shar

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Lo, Charles G., Theresa T. Lu, and Jason G. Cyster. "Integrin-dependence of Lymphocyte Entry into the Splenic White Pulp." Journal of Experimental Medicine 197, no. 3 (2003): 353–61. http://dx.doi.org/10.1084/jem.20021569.

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The steps involved in lymphocyte homing to the white pulp cords of the spleen are poorly understood. We demonstrate here that the integrins lymphocyte function associated (LFA)-1 and α4β1 make essential and mostly overlapping contributions necessary for B cell migration into white pulp cords. T cell entry to the white pulp is also reduced by blockade of LFA-1 and α4β1. The LFA-1 ligand, intercellular adhesion molecule 1 is critical for lymphocyte entry and both hematopoietic cells and radiation-resistant cells contribute to this requirement. Vascular cell adhesion molecule 1 contributes to the

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Picker, L. J., M. Nakache, and E. C. Butcher. "Monoclonal antibodies to human lymphocyte homing receptors define a novel class of adhesion molecules on diverse cell types." Journal of Cell Biology 109, no. 2 (1989): 927–37. http://dx.doi.org/10.1083/jcb.109.2.927.

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A 90-kD lymphocyte surface glycoprotein, defined by monoclonal antibodies of the Hermes series, is involved in lymphocyte recognition of high endothelial venules (HEV). Lymphocyte gp90Hermes binds in a saturable, reversible fashion to the mucosal vascular addressin (MAd), a tissue-specific endothelial cell adhesion molecule for lymphocytes. We and others have recently shown that the Hermes antigen is identical to or includes CD44 (In[Lu]-related p80), human Pgp-1, and extracellular matrix receptor III-molecules reportedly expressed on diverse cell types. Here, we examine the relationship betwe

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Yu, Yamei, Jianghai Zhu, Li-Zhi Mi та ін. "Structural specializations of α4β7, an integrin that mediates rolling adhesion". Journal of Cell Biology 196, № 1 (2012): 131–46. http://dx.doi.org/10.1083/jcb.201110023.

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The lymphocyte homing receptor integrin α4β7 is unusual for its ability to mediate both rolling and firm adhesion. α4β1 and α4β7 are targeted by therapeutics approved for multiple sclerosis and Crohn’s disease. Here, we show by electron microscopy and crystallography how two therapeutic Fabs, a small molecule (RO0505376), and mucosal adhesion molecule-1 (MAdCAM-1) bind α4β7. A long binding groove at the α4–β7 interface for immunoglobulin superfamily domains differs in shape from integrin pockets that bind Arg-Gly-Asp motifs. RO0505376 mimics an Ile/Leu-Asp motif in α4 ligands, and orients diff

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Chin, Y. H., J. P. Cai, and K. Johnson. "Lymphocyte adhesion to cultured Peyer's patch high endothelial venule cells is mediated by organ-specific homing receptors and can be regulated by cytokines." Journal of Immunology 145, no. 11 (1990): 3669–77. http://dx.doi.org/10.4049/jimmunol.145.11.3669.

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Abstract Adhesion of lymphocytes to high endothelial venule (HEV) cells is the first step in the migration of these cells from blood into lymph nodes and Peyer's patches (PP). In the present study, we isolated and cultured HEV cells from PP of the rat and assessed their capacity to interact with lymphocytes. Flow cytometric analysis with a rat HEV-specific mAb KJ-4 revealed that greater than 90% of the cultured cells were stained by the antibody. Furthermore, confluent monolayers of PP HEV cells retained the capacity to support the adhesion of lymphocytes from spleen, thoracic duct, and lymph

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Johnston, J. A., D. D. Taub, A. R. Lloyd, K. Conlon, J. J. Oppenheim, and D. J. Kevlin. "Human T lymphocyte chemotaxis and adhesion induced by vasoactive intestinal peptide." Journal of Immunology 153, no. 4 (1994): 1762–68. http://dx.doi.org/10.4049/jimmunol.153.4.1762.

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Abstract Vasoactive intestinal peptide (VIP), a 28-amino acid peptide of the glucagon-secretin family, has been reported to have significant immunoregulatory properties. In the present study, we demonstrate that VIP has potent chemotactic effects on T lymphocytes. At concentrations of between 10(-8) and 10(-9) M, VIP stimulated significant in vitro chemotaxis of T lymphocytes from both CD4+ and CD8+ subsets. VIP produced more potent chemotactic effects on unstimulated T cells than on anti-CD3-activated cells. Following anti-CD3 activation, binding of 125I-labeled VIP to T cells was reduced and

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Sikorski, E. E., R. Hallmann, E. L. Berg, and E. C. Butcher. "The Peyer's patch high endothelial receptor for lymphocytes, the mucosal vascular addressin, is induced on a murine endothelial cell line by tumor necrosis factor-alpha and IL-1." Journal of Immunology 151, no. 10 (1993): 5239–50. http://dx.doi.org/10.4049/jimmunol.151.10.5239.

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Abstract The specificity of lymphocyte homing from the blood into a tissue is determined in part by complementary pairs of adhesion receptors on lymphocytes and endothelial cells termed homing receptors and vascular addressins, respectively. The mucosal vascular addressin involved in lymphocyte homing to Peyer's patches is a 66-kDa glycoprotein, MAdCAM-1. Investigation of the regulation and molecular genetics of MAdCAM-1 have been hampered by the lack of a murine cell line expressing this adhesion molecule. We show herein using indirect immunofluorescence studies that MAdCAM-1 can be induced o

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Irani, D. N., and D. E. Griffin. "Regulation of lymphocyte homing into the brain during viral encephalitis at various stages of infection." Journal of Immunology 156, no. 10 (1996): 3850–57. http://dx.doi.org/10.4049/jimmunol.156.10.3850.

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Abstract The passage of circulating lymphocytes into the central nervous system (CNS) during acute viral encephalitis was studied in vivo using fluorescently labeled cells inoculated into Sindbis virus (SV)-infected mice. Donor lymphocytes were detected in the brains of recipient animals when mononuclear cells were isolated from the CNS and screened by flow cytometry. The magnitude of this accumulation related to the duration of encephalitis in recipient mice and to the activation state of the inoculated cells. While Ag specificity did not influence lymphocyte entry into the inflamed CNS at an

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Kansas, G. S., O. Spertini, L. M. Stoolman, and T. F. Tedder. "Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1." Journal of Cell Biology 114, no. 2 (1991): 351–58. http://dx.doi.org/10.1083/jcb.114.2.351.

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The human lymphocyte homing receptor LAM-1, like its murine counterpart MEL-14, functions as a mammalian lectin, and mediates the binding of leukocytes to specialized high endothelial cells in lymphoid organs (HEV). LAM-1 is a member of a new family of cell adhesion molecules, termed selectins or LEC-CAMs, which also includes ELAM-1 and PAD-GEM (GMP-140/CD62). To localize the regions of LAM-1 that are involved in cell adhesion, we developed chimeric selectins, in which various domains of PAD-GEM were substituted into LAM-1, and used these chimeric proteins to define the domain requirements for

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Stein, Jens V., Antal Rot, Yi Luo, et al. "The Cc Chemokine Thymus-Derived Chemotactic Agent 4 (Tca-4, Secondary Lymphoid Tissue Chemokine, 6ckine, Exodus-2) Triggers Lymphocyte Function–Associated Antigen 1–Mediated Arrest of Rolling T Lymphocytes in Peripheral Lymph Node High Endothelial Venules." Journal of Experimental Medicine 191, no. 1 (2000): 61–76. http://dx.doi.org/10.1084/jem.191.1.61.

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T cell homing to peripheral lymph nodes (PLNs) is defined by a multistep sequence of interactions between lymphocytes and endothelial cells in high endothelial venules (HEVs). After initial tethering and rolling via L-selectin, firm adhesion of T cells requires rapid upregulation of lymphocyte function–associated antigen 1 (LFA-1) adhesiveness by a previously unknown pathway that activates a Gαi-linked receptor. Here, we used intravital microscopy of murine PLNs to study the role of thymus-derived chemotactic agent (TCA)-4 (secondary lymphoid tissue chemokine, 6Ckine, Exodus-2) in homing of ad

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Szekanecz, Z., M. J. Humphries, and A. Ager. "Lymphocyte adhesion to high endothelium is mediated by two beta 1 integrin receptors for fibronectin, alpha 4 beta 1 and alpha 5 beta 1." Journal of Cell Science 101, no. 4 (1992): 885–94. http://dx.doi.org/10.1242/jcs.101.4.885.

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Using a rat model we have previously proposed a role for fibronectin as an adhesive ligand on high endothelial cells (HEC) for recirculating lymphocytes. Lymphocyte adhesion to high endothelial cells was blocked by CS1 peptide (from the type III connecting segment of fibronectin) and RGD-containing peptides using two different in vitro assays of lymphocyte-HEC recognition, the frozen section assay and cultured HEC. In order to study the receptors utilised by lymphocytes to bind to HEC we have developed a xenogeneic model in which the adhesion of human lymphocytes to HEC cultured from rat lymph

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Prevo, Remko, Suneale Banerji, Jian Ni, and David G. Jackson. "Rapid Plasma Membrane-Endosomal Trafficking of the Lymph Node Sinus and High Endothelial Venule Scavenger Receptor/Homing Receptor Stabilin-1 (Feel-1/Clever-1)." Journal of Biological Chemistry 279, no. 50 (2004): 52580–92. http://dx.doi.org/10.1074/jbc.m406897200.

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The sinusoidal endothelia of liver, spleen, and lymph node are major sites for uptake and recycling of waste macromolecules through promiscuous binding to a disparate family of scavenger receptors. Among the most complex is stabilin-1, a large multidomain protein containing tandem fasciclin domains, epidermal growth factor-like repeats, and a C-type lectin-like hyaluronan-binding Link module, which functions as an endocytic receptor for acetylated low density lipoprotein and advanced glycation end products. Intriguingly, stabilin-1 has also been reported to mediate both homing of leukocytes ac

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Spiegel, Asaf, Orit Kollet, Amnon Peled, et al. "Unique SDF-1–induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling." Blood 103, no. 8 (2004): 2900–2907. http://dx.doi.org/10.1182/blood-2003-06-1891.

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Abstract The mechanisms governing migration and extramedullary dissemination of leukemic cells remain obscure. In this study the migration and in vivo homing to the bone marrow of nonobese diabetic severe combined immunodeficient (NOD/SCID) mice injected with human precursor-B acute lymphoblastic leukemia (ALL) cells in comparison to normal CD34+ progenitors (both cord blood and mobilized peripheral blood) was investigated. Although migration and homing of both cell populations was dependent on stromal cell-derived factor 1 (SDF-1)/CXCR4 interactions, major differences in receptor expression a

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Onder, Lucas, Renzo Danuser, Elke Scandella та ін. "Endothelial cell–specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation". Journal of Experimental Medicine 210, № 3 (2013): 465–73. http://dx.doi.org/10.1084/jem.20121462.

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The development of lymph nodes (LNs) and formation of LN stromal cell microenvironments is dependent on lymphotoxin-β receptor (LTβR) signaling. In particular, the LTβR-dependent crosstalk between mesenchymal lymphoid tissue organizer and hematopoietic lymphoid tissue inducer cells has been regarded as critical for these processes. Here, we assessed whether endothelial cell (EC)–restricted LTβR signaling impacts on LN development and the vascular LN microenvironment. Using EC-specific ablation of LTβR in mice, we found that conditionally LTβR-deficient animals failed to develop a significant p

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Hamburger, SA, and RP McEver. "GMP-140 mediates adhesion of stimulated platelets to neutrophils." Blood 75, no. 3 (1990): 550–54. http://dx.doi.org/10.1182/blood.v75.3.550.550.

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Abstract In vivo, platelets associate with neutrophils at sites of hemorrhage or inflammation. In vitro, stimulated platelets bind to neutrophils in a Ca2(+)-dependent manner. GMP-140, an integral membrane glycoprotein found in secretory granules of platelets and endothelium, is rapidly translocated to the cell surface after cellular activation. It shares sequence similarity with two leukocyte adhesion molecules, ELAM-1 and a lymphocyte homing receptor. We have recently shown that neutrophils bind to purified GMP-140 in a Ca2(+)-dependent fashion, and that GMP- 140 participates in adhesion of

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Hamburger, SA, and RP McEver. "GMP-140 mediates adhesion of stimulated platelets to neutrophils." Blood 75, no. 3 (1990): 550–54. http://dx.doi.org/10.1182/blood.v75.3.550.bloodjournal753550.

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In vivo, platelets associate with neutrophils at sites of hemorrhage or inflammation. In vitro, stimulated platelets bind to neutrophils in a Ca2(+)-dependent manner. GMP-140, an integral membrane glycoprotein found in secretory granules of platelets and endothelium, is rapidly translocated to the cell surface after cellular activation. It shares sequence similarity with two leukocyte adhesion molecules, ELAM-1 and a lymphocyte homing receptor. We have recently shown that neutrophils bind to purified GMP-140 in a Ca2(+)-dependent fashion, and that GMP- 140 participates in adhesion of neutrophi

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Rott, L. S., M. J. Briskin, D. P. Andrew, E. L. Berg, and E. C. Butcher. "A fundamental subdivision of circulating lymphocytes defined by adhesion to mucosal addressin cell adhesion molecule-1. Comparison with vascular cell adhesion molecule-1 and correlation with beta 7 integrins and memory differentiation." Journal of Immunology 156, no. 10 (1996): 3727–36. http://dx.doi.org/10.4049/jimmunol.156.10.3727.

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Abstract The leukocyte integrin alpha 4 beta 7 is a receptor for the vascular mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Most circulating B and T lymphocytes in man are alpha 4+, and on these cells the regulated display of the beta 7 integrin chain determines the expression of alpha 4 beta 7 and, in large part, binding to MAdCAM-1. Among CD4+ T cells, beta 7 high memory cells (including the L-selectin+ subset) bind MAdCAM-1 better than beta 7int naive cells; whereas beta 7- memory cells,including skin homing lymphocytes, interact poorly if at all. Circulating alpha E beta 7+ T cell

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Spertini, O., F. W. Luscinskas, G. S. Kansas, et al. "Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion." Journal of Immunology 147, no. 8 (1991): 2565–73. http://dx.doi.org/10.4049/jimmunol.147.8.2565.

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Abstract The human lymphocyte homing receptor, LAM-1, mediates the adhesion of lymphocytes to specialized high endothelial venules (HEV) of peripheral lymph nodes. We now report that LAM-1 is also a major mediator of leukocyte attachment to activated human endothelium. In a novel adhesion assay, LAM-1 was shown to mediate approximately 50% of the adhesion of both lymphocytes and neutrophils to TNF-activated human umbilical vein endothelial cells at 4 degrees C. The contribution of LAM-1 to leukocyte adhesion was only detectable when the assays were carried out under rotating (nonstatic) condit

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Leung, D. Y., M. Gately, A. Trumble, B. Ferguson-Darnell, P. M. Schlievert, and L. J. Picker. "Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production." Journal of Experimental Medicine 181, no. 2 (1995): 747–53. http://dx.doi.org/10.1084/jem.181.2.747.

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T lymphocyte infiltration is a prominent feature of the skin inflammation associated with infections by toxin (superantigen)-secreting Staphylococcus aureus or Streptococcus bacteria. The cutaneous lymphocyte-associated antigen (CLA) has been hypothesized to be a homing receptor (HR) involved in selective migration of memory/effector T cells to the skin. Since the expression of this putative skin-selective HR is known to be under strict microenvironmental control, we sought to determine the effect of staphylococcal and streptococcal toxins on T cell expression of CLA. After in vitro stimulatio

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Peled, Amnon, Orit Kollet, Tanya Ponomaryov, et al. "The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34+ cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice." Blood 95, no. 11 (2000): 3289–96. http://dx.doi.org/10.1182/blood.v95.11.3289.

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Abstract Hematopoietic stem cell homing and engraftment require several adhesion interactions, which are not fully understood. Engraftment of nonobese/severe combined immunodeficiency (NOD/SCID) mice by human stem cells is dependent on the major integrins very late activation antigen–4 (VLA-4); VLA-5; and to a lesser degree, lymphocyte function associated antigen–1 (LFA-1). Treatment of human CD34+cells with antibodies to either VLA-4 or VLA-5 prevented engraftment, and treatment with anti–LFA-1 antibodies significantly reduced the levels of engraftment. Activation of CD34+ cells, which bear t

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Peled, Amnon, Orit Kollet, Tanya Ponomaryov, et al. "The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34+ cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice." Blood 95, no. 11 (2000): 3289–96. http://dx.doi.org/10.1182/blood.v95.11.3289.011k33_3289_3296.

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Hematopoietic stem cell homing and engraftment require several adhesion interactions, which are not fully understood. Engraftment of nonobese/severe combined immunodeficiency (NOD/SCID) mice by human stem cells is dependent on the major integrins very late activation antigen–4 (VLA-4); VLA-5; and to a lesser degree, lymphocyte function associated antigen–1 (LFA-1). Treatment of human CD34+cells with antibodies to either VLA-4 or VLA-5 prevented engraftment, and treatment with anti–LFA-1 antibodies significantly reduced the levels of engraftment. Activation of CD34+ cells, which bear the chemok

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