Log in

Relevant bibliographies by topics / Gpa2 / Journal articles

To see the other types of publications on this topic, follow the link: Gpa2.

Journal articles on the topic 'Gpa2'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Gpa2.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Shen, Gui, Yan-Li Wang, Amy Whittington, Lie Li, and Ping Wang. "The RGS Protein Crg2 Regulates Pheromone and Cyclic AMP Signaling in Cryptococcus neoformans." Eukaryotic Cell 7, no. 9 (2008): 1540–48. http://dx.doi.org/10.1128/ec.00154-08.

Full text

Abstract:

ABSTRACT Crg1 and Crg2 are regulators of G-protein signaling homologs found in the human fungal pathogen Cryptococcus neoformans. Crg1 negatively regulates pheromone responses and mating through direct inhibition of Gα subunits Gpa2 and Gpa3. It has also been proposed that Crg2 has a role in mating, as genetic crosses involving Δcrg2 mutants resulted in formation of hyperfilaments. We found that mutation of Gpa2 and Gpa3 partially suppressed the hyperfilamentation, mutation of Gpa3 alleviated Δcrg2-specfic cell swelling, and mutation of the mitogen-activated protein kinase Cpk1 blocked both pr

APA, Harvard, Vancouver, ISO, and other styles

2

Hsueh, Yen-Ping, Chaoyang Xue та Joseph Heitman. "G protein signaling governing cell fate decisions involves opposing Gα subunits inCryptococcus neoformans". Molecular Biology of the Cell 18, № 9 (2007): 3237–49. http://dx.doi.org/10.1091/mbc.e07-02-0133.

Full text

Abstract:

Communication between cells and their environments is often mediated by G protein-coupled receptors and cognate G proteins. In fungi, one such signaling cascade is the mating pathway triggered by pheromone/pheromone receptor recognition. Unlike Saccharomyces cerevisiae, which expresses two Gα subunits, most filamentous ascomycetes and basidiomycetes have three Gα subunits. Previous studies have defined the Gα subunit acting upstream of the cAMP-protein kinase A pathway, but it has been unclear which Gα subunit is coupled to the pheromone receptor and response pathway. Here we report that in th

APA, Harvard, Vancouver, ISO, and other styles

3

Gong, Jinjun, Jacob D. Grodsky, Zhengguang Zhang, and Ping Wang. "A Ric8/Synembryn Homolog Promotes Gpa1 and Gpa2 Activation To Respectively Regulate Cyclic AMP and Pheromone Signaling in Cryptococcus neoformans." Eukaryotic Cell 13, no. 10 (2014): 1290–99. http://dx.doi.org/10.1128/ec.00109-14.

Full text

Abstract:

ABSTRACTThe G protein α subunits Gpa1, Gpa2, and Gpa3 mediate signal transduction and are important in the growth and virulence ofCryptococcus neoformans. To understand how Gpa1 functions without a conventional Gβ subunit, we characterized a resistance to inhibitors of cholinesterase 8 (Ric8) homolog fromC. neoformans, which shares amino acid sequence homology with other Ric8 proteins that exhibit guanine nucleotide exchange factor (GEF) activity toward Gα. We found that theric8mutant was reduced in capsule size and melanin formation, which could be suppressed by cyclic AMP (cAMP) supplementat

APA, Harvard, Vancouver, ISO, and other styles

4

Li, Lie, Gui Shen, Zheng-Guang Zhang, Yan-Li Wang, Jill K. Thompson, and Ping Wang. "Canonical Heterotrimeric G Proteins Regulating Mating and Virulence ofCryptococcus neoformans." Molecular Biology of the Cell 18, no. 11 (2007): 4201–9. http://dx.doi.org/10.1091/mbc.e07-02-0136.

Full text

Abstract:

Perturbation of pheromone signaling modulates not only mating but also virulence in Cryptococcus neoformans, an opportunistic human pathogen known to encode three Gα, one Gβ, and two Gγ subunit proteins. We have found that Gαs Gpa2 and Gpa3 exhibit shared and distinct roles in regulating pheromone responses and mating. Gpa2 interacted with the pheromone receptor homolog Ste3α, Gβ subunit Gpb1, and RGS protein Crg1. Crg1 also exhibited in vitro GAP activity toward Gpa2. These findings suggest that Gpa2 regulates mating through a conserved signaling mechanism. Moreover, we found that Gγs Gpg1 an

APA, Harvard, Vancouver, ISO, and other styles

5

Meza-Carmen, Victor, Jesús García-Soto, Laura Ongay-Larios та ін. "Molecular characterization of a G protein α-subunit-encoding gene fromMucor circinelloides". Canadian Journal of Microbiology 52, № 7 (2006): 627–35. http://dx.doi.org/10.1139/w06-010.

Full text

Abstract:

Genes encoding the Gα subunit were cloned from Mucor circinelloides, a zygomycete dimorphic fungus. There are at least four genes that encode for Gα subunits, gpa1, gpa2, gpa3, and gpa4. The genes gpa1 and gpa3 were isolated and characterized, and their predicted products showed 36%–67% identity with Gα subunits from diverse fungi. Northern blot analysis of gpa3 showed that it is present in spores and constitutively expressed during mycelium development and during yeast–mycelium and mycelium–yeast transitions. However, during yeast cell growth, decreased levels of mRNA were observed. Sequence

APA, Harvard, Vancouver, ISO, and other styles

6

Landry, Sheila, Maria T. Pettit, Ethel Apolinario та Charles S. Hoffman. "The Fission Yeast git5 Gene Encodes a Gβ Subunit Required for Glucose-Triggered Adenylate Cyclase Activation". Genetics 154, № 4 (2000): 1463–71. http://dx.doi.org/10.1093/genetics/154.4.1463.

Full text

Abstract:

Abstract Fission yeast adenylate cyclase is activated by the gpa2 Gα subunit of a heterotrimeric guanine-nucleotide binding protein (G protein). We show that the git5 gene, also required for this activation, encodes a Gβ subunit. In contrast to another study, we show that git5 is not a negative regulator of the gpa1 Gα involved in the pheromone response pathway. While 43% identical to mammalian Gβ's, the git5 protein lacks the amino-terminal coiled-coil found in other Gβ subunits, yet the gene possesses some of the coding capacity for this structure 5′ to its ORF. Although both gpa2 (Gα) and g

APA, Harvard, Vancouver, ISO, and other styles

7

Ivey, F. Douglas, Francis X. Taglia, Fan Yang, Matthew M. Lander, David A. Kelly та Charles S. Hoffman. "Activated Alleles of the Schizosaccharomyces pombegpa2+ Gα Gene Identify Residues Involved in GDP-GTP Exchange". Eukaryotic Cell 9, № 4 (2010): 626–33. http://dx.doi.org/10.1128/ec.00010-10.

Full text

Abstract:

ABSTRACT The Schizosaccharomyces pombe glucose/cyclic AMP (cAMP) signaling pathway includes the Gpa2-Git5-Git11 heterotrimeric G protein, whose Gpa2 Gα subunit directly binds to and activates adenylate cyclase in response to signaling from the Git3 G protein-coupled receptor. To study intrinsic and extrinsic regulation of Gpa2, we developed a plasmid-based screen to identify mutationally activated gpa2 alleles that bypass the loss of the Git5-Git11 Gβγ dimer to repress transcription of the glucose-regulated fbp1 + gene. Fifteen independently isolated mutations alter 11 different Gpa2 residues,

APA, Harvard, Vancouver, ISO, and other styles

8

Miwa, Takuya, Yukinobu Takagi, Makiko Shinozaki, et al. "Gpr1, a Putative G-Protein-Coupled Receptor, Regulates Morphogenesis and Hypha Formation in the Pathogenic Fungus Candida albicans." Eukaryotic Cell 3, no. 4 (2004): 919–31. http://dx.doi.org/10.1128/ec.3.4.919-931.2004.

Full text

Abstract:

ABSTRACT In response to various extracellular signals, the morphology of the human fungal pathogen Candida albicans switches from yeast to hypha form. Here, we report that GPR1 encoding a putative G-protein-coupled receptor and GPA2 encoding a Gα subunit are required for hypha formation and morphogenesis in C. albicans. Mutants lacking Gpr1 (gpr1/gpr1) or Gpa2 (gpa2/gpa2) are defective in hypha formation and morphogenesis on solid hypha-inducing media. These phenotypic defects in solid cultures are suppressed by exogenously added dibutyryl-cyclic AMP (dibutyryl-cAMP). Biochemical studies also

APA, Harvard, Vancouver, ISO, and other styles

9

Sudo, Satoko, Yoshimitsu Kuwabara, Jae-Il Park, Sheau Yu Hsu та Aaron J. W. Hsueh. "Heterodimeric Fly Glycoprotein Hormone-α2 (GPA2) and Glycoprotein Hormone-β5 (GPB5) Activate Fly Leucine-Rich Repeat-Containing G Protein-Coupled Receptor-1 (DLGR1) and Stimulation of Human Thyrotropin Receptors by Chimeric Fly GPA2 and Human GPB5". Endocrinology 146, № 8 (2005): 3596–604. http://dx.doi.org/10.1210/en.2005-0317.

Full text

Abstract:

Abstract Glycoprotein hormones play important roles in thyroid and gonadal function in vertebrates. The glycoprotein hormone α-subunit forms heterodimers with different β-subunits to activate TSH or gonadotropin (LH and FSH) receptors. Recent genomic analyses allowed the identification of another α-subunit, GPA2, and another β-subunit, GPB5, in human, capable of forming heterodimers to activate TSH receptors. Based on comparative genomic searches, we isolated the fly orthologs for human GPA2 and GPB5, each consisting of 10 cysteine residues likely involved in cystine-knot formation. RT-PCR ana

APA, Harvard, Vancouver, ISO, and other styles

10

Harashima, Toshiaki, та Joseph Heitman. "Gα Subunit Gpa2 Recruits Kelch Repeat Subunits That Inhibit Receptor-G Protein Coupling during cAMP-induced Dimorphic Transitions in Saccharomyces cerevisiae". Molecular Biology of the Cell 16, № 10 (2005): 4557–71. http://dx.doi.org/10.1091/mbc.e05-05-0403.

Full text

Abstract:

All eukaryotic cells sense extracellular stimuli and activate intracellular signaling cascades via G protein-coupled receptors (GPCR) and associated heterotrimeric G proteins. The Saccharomyces cerevisiae GPCR Gpr1 and associated Gα subunit Gpa2 sense extracellular carbon sources (including glucose) to govern filamentous growth. In contrast to conventional Gα subunits, Gpa2 forms an atypical G protein complex with the kelch repeat Gβ mimic proteins Gpb1 and Gpb2. Gpb1/2 negatively regulate cAMP signaling by inhibiting Gpa2 and an as yet unidentified target. Here we show that Gpa2 requires lipi

APA, Harvard, Vancouver, ISO, and other styles

11

Sánchez-Martínez, Cristina, та José Pérez-Martín. "Gpa2, a G-Protein α Subunit Required for Hyphal Development in Candida albicans". Eukaryotic Cell 1, № 6 (2002): 865–74. http://dx.doi.org/10.1128/ec.1.6.865-874.2002.

Full text

Abstract:

ABSTRACT Candida albicans is able to respond to environmental changes by inducing a distinct morphological program, which is related to the ability to infect mammalian hosts. Although some of the signal transduction pathways involved in this response are known, it is not clear how the environmental signals are sensed and transmitted to these transduction cascades. In this work, we have studied the function of GPA2, a new gene from C. albicans, which encodes a G-protein α-subunit homologue. We demonstrate that Gpa2 plays an important role in the yeast-hypha dimorphic transition in the response

APA, Harvard, Vancouver, ISO, and other styles

12

Mudge, Dayna K., Fan Yang, Brian M. Currie, et al. "Sck1 Negatively Regulates Gpa2-Mediated Glucose Signaling in Schizosaccharomyces pombe." Eukaryotic Cell 13, no. 2 (2013): 202–8. http://dx.doi.org/10.1128/ec.00277-13.

Full text

Abstract:

ABSTRACTSchizosaccharomyces pombedetects extracellular glucose via a G protein-mediated cyclic AMP (cAMP)-signaling pathway activating protein kinase A (PKA) and regulating transcription of genes involved in metabolism and sexual development. In this pathway, Gpa2 Gα binds to and activates adenylyl cyclase in response to glucose detection by the Git3 G protein-coupled receptor. Using a two-hybrid screen to identify extrinsic regulators of Gpa2, we isolated a clone that expresses codons 471 to 696 of the Sck1 kinase, which appears to display a higher affinity for Gpa2K270E-activated Gα relative

APA, Harvard, Vancouver, ISO, and other styles

13

Dos Santos, Sandra, Claire Bardet, Stephanie Bertrand, Hector Escriva, Damien Habert та Bruno Querat. "Distinct Expression Patterns of Glycoprotein Hormone-α2 and -β5 in a Basal Chordate Suggest Independent Developmental Functions". Endocrinology 150, № 8 (2009): 3815–22. http://dx.doi.org/10.1210/en.2008-1743.

Full text

Abstract:

The vertebrate glycoprotein hormones (GpHs), gonadotropins and thyrotropin, are heterodimers composed of a common α- and specific β-subunit. The recombinant heterodimer of two additional, structurally related proteins identified in vertebrate and protostome genomes, the glycoproteins-α2 (GPA2) and-β5 (GPB5), was shown to activate the thyrotropin receptor and was therefore named thyrostimulin. However, differences in tissue distribution and expression levels of these proteins suggested that they might act as nonassociated factors, prompting further investigation on these proteins. In this study

APA, Harvard, Vancouver, ISO, and other styles

14

Nocero, M., T. Isshiki, M. Yamamoto, and C. S. Hoffman. "Glucose repression of fbp1 transcription of Schizosaccharomyces pombe is partially regulated by adenylate cyclase activation by a G protein alpha subunit encoded by gpa2 (git8)." Genetics 138, no. 1 (1994): 39–45. http://dx.doi.org/10.1093/genetics/138.1.39.

Full text

Abstract:

Abstract In the fission yeast Schizosaccharomyces pombe, genetic studies have identified genes that are required for glucose repression of fbp1 transcription. The git2 gene, also known as cyr1, encodes adenylate cyclase. Adenylate cyclase converts ATP into the second messenger cAMP as part of many eukaryotic signal transduction pathways. The git1, git3, git5, git7, git8 and git10 genes act upstream of adenylate cyclase, presumably encoding an adenylate cyclase activation pathway. In mammalian cells, adenylate cyclase enzymatic activity is regulated by heterotrimeric guanine nucleotide-binding

APA, Harvard, Vancouver, ISO, and other styles

15

van der Voort, Jeroen Rouppe, Konstantin Kanyuka, Edwin van der Vossen, et al. "Tight Physical Linkage of the Nematode Resistance Gene Gpa2 and the Virus Resistance Gene Rx on a Single Segment Introgressed from the Wild Species Solanum tuberosum subsp. andigena CPC 1673 into Cultivated Potato." Molecular Plant-Microbe Interactions® 12, no. 3 (1999): 197–206. http://dx.doi.org/10.1094/mpmi.1999.12.3.197.

Full text

Abstract:

Comparative mapping studies within several plant genera have shown that genes for resistance to taxonomically diverse pathogens are often co-localized on the maps of these genotypes. Here we describe the genetic analysis of such a gene cluster on chromosome 12 of potato. This cluster harbors the resistance loci Gpa2 and Rx, which confer resistance to the potato cyst nematode Globodera pallida and potato virus X (PVX), respectively. By screening two mapping populations with 10 CAPS (cleaved amplified polymorphic sequence) markers derived from AFLP (amplified fragment length polymorphism) marker

APA, Harvard, Vancouver, ISO, and other styles

16

Landry, Sheila, та Charles S. Hoffman. "The git5 Gβ and git11 Gγ Form an Atypical Gβγ Dimer Acting in the Fission Yeast Glucose/cAMP Pathway". Genetics 157, № 3 (2001): 1159–68. http://dx.doi.org/10.1093/genetics/157.3.1159.

Full text

Abstract:

AbstractFission yeast adenylate cyclase, like mammalian adenylate cyclases, is regulated by a heterotrimeric G protein. The gpa2 Gα and git5 Gβ are both required for glucose-triggered cAMP signaling. The git5 Gβ is a unique member of the Gβ family in that it lacks an amino-terminal coiled-coil domain shown to be essential for mammalian Gβ folding and interaction with Gγ subunits. Using a git5 bait in a two-hybrid screen, we identified the git11 Gγ gene. Co-immunoprecipitation studies confirm the composition of this Gβγ dimer. Cells deleted for git11 are defective in glucose repression of both

APA, Harvard, Vancouver, ISO, and other styles

17

Hsu, Sheau Yu, Koji Nakabayashi, and Alka Bhalla. "Evolution of Glycoprotein Hormone Subunit Genes in Bilateral Metazoa: Identification of Two Novel Human Glycoprotein Hormone Subunit Family Genes, GPA2 and GPB5." Molecular Endocrinology 16, no. 7 (2002): 1538–51. http://dx.doi.org/10.1210/mend.16.7.0871.

Full text

Abstract:

Abstract The canonical members of the human glycoprotein hormone subunit family of cystine knot-forming polypeptides include the common α-subunit, and four β-subunit genes, FSHβ, LHβ, TSHβ, and hCGβ. Using pairwise sequence analysis of the complete human genome, we have identified two novel glycoprotein hormone subunit-related genes. Based on unique sequence similarity to the α- and β-subunits of glycoprotein hormones, they were named glycoprotein-α2 (GPA2) and glycoprotein-β5 (GPB5), respectively. PCR analysis using a panel of human cDNAs from 14 different tissues demonstrated that GPB5 is si

APA, Harvard, Vancouver, ISO, and other styles

18

Donzeau, Mariel, та Wolfhard Bandlow. "The Yeast Trimeric Guanine Nucleotide-Binding Protein α Subunit, Gpa2p, Controls the Meiosis-Specific Kinase Ime2p Activity in Response to Nutrients". Molecular and Cellular Biology 19, № 9 (1999): 6110–19. http://dx.doi.org/10.1128/mcb.19.9.6110.

Full text

Abstract:

ABSTRACT Saccharomyces cerevisiae Gpa2p, the α subunit of a heterotrimeric guanine nucleotide-binding protein (G protein), is involved in the regulation of vegetative growth and pseudohyphal development. Here we report that Gpa2p also controls sporulation by interacting with the regulatory domain of Ime2p (Sme1p), a protein kinase essential for entrance of meiosis and sporulation. Protein-protein interactions between Gpa2p and Ime2p depend on the GTP-bound state of Gpa2p and correlate with down-regulation of Ime2p kinase activity in vitro. Overexpression of Ime2p inhibits pseudohyphal developm

APA, Harvard, Vancouver, ISO, and other styles

19

Chasse, Scott A., Paul Flanary, Stephen C. Parnell, et al. "Genome-Scale Analysis Reveals Sst2 as the Principal Regulator of Mating Pheromone Signaling in the Yeast Saccharomyces cerevisiae." Eukaryotic Cell 5, no. 2 (2006): 330–46. http://dx.doi.org/10.1128/ec.5.2.330-346.2006.

Full text

Abstract:

ABSTRACT A common property of G protein-coupled receptors is that they become less responsive with prolonged stimulation. Regulators of G protein signaling (RGS proteins) are well known to accelerate G protein GTPase activity and do so by stabilizing the transition state conformation of the G protein α subunit. In the yeast Saccharomyces cerevisiae there are four RGS-homologous proteins (Sst2, Rgs2, Rax1, and Mdm1) and two Gα proteins (Gpa1 and Gpa2). We show that Sst2 is the only RGS protein that binds selectively to the transition state conformation of Gpa1. The other RGS proteins also bind

APA, Harvard, Vancouver, ISO, and other styles

20

Tulinov, Aleksey. "GENETIC SCREENING OF PROMISING POTATO HYBRIDS OF KOMI REPUBLIC." Vestnik of Kazan State Agrarian University 19, no. 3 (2024): 48–51. http://dx.doi.org/10.12737/2073-0462-2024-48-51.

Full text

Abstract:

The studies were conducted with the aim of genetic screening of promising selection hybrids of potatoes to identify genotypes resistant to a complex of phytopathogens. The study was carried out at A.V.Zhuravskiy Institute of Agrobiotechnology of Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences and Sintol company (Moscow) using the GenExpert reagent kit “Markers of potato resistance genes” (“Syntol”). For the study, 10 markers of genes encoding resistance to potato cancer, golden potato cyst nematode, pale potato cyst nematode, X-virus and Y-virus were selected (gene

APA, Harvard, Vancouver, ISO, and other styles

21

Bassett, J. H. Duncan, Anne van der Spek, John G. Logan, et al. "Thyrostimulin Regulates Osteoblastic Bone Formation During Early Skeletal Development." Endocrinology 156, no. 9 (2015): 3098–113. http://dx.doi.org/10.1210/en.2014-1943.

Full text

Abstract:

The ancestral glycoprotein hormone thyrostimulin is a heterodimer of unique glycoprotein hormone subunit alpha (GPA)2 and glycoprotein hormone subunit beta (GPB)5 subunits with high affinity for the TSH receptor. Transgenic overexpression of GPB5 in mice results in cranial abnormalities, but the role of thyrostimulin in bone remains unknown. We hypothesized that thyrostimulin exerts paracrine actions in bone and determined: 1) GPA2 and GPB5 expression in osteoblasts and osteoclasts, 2) the skeletal consequences of thyrostimulin deficiency in GPB5 knockout (KO) mice, and 3) osteoblast and osteo

APA, Harvard, Vancouver, ISO, and other styles

22

Cheranda, Nina Kiran, Shan Huang, and Yuqi Wang. "Investigating the Effects of Gpa2 Phosphorylation on Yeast Sporulation." FASEB Journal 34, S1 (2020): 1. http://dx.doi.org/10.1096/fasebj.2020.34.s1.02710.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Li, Shuang, Yuanyuan Li, Blake R. Rushing та ін. "Multi-omics analysis of glucose-mediated signaling by a moonlighting Gβ protein Asc1/RACK1". PLOS Genetics 17, № 7 (2021): e1009640. http://dx.doi.org/10.1371/journal.pgen.1009640.

Full text

Abstract:

Heterotrimeric G proteins were originally discovered through efforts to understand the effects of hormones, such as glucagon and epinephrine, on glucose metabolism. On the other hand, many cellular metabolites, including glucose, serve as ligands for G protein-coupled receptors. Here we investigate the consequences of glucose-mediated receptor signaling, and in particular the role of a Gα subunit Gpa2 and a non-canonical Gβ subunit, known as Asc1 in yeast and RACK1 in animals. Asc1/RACK1 is of particular interest because it has multiple, seemingly unrelated, functions in the cell. The existenc

APA, Harvard, Vancouver, ISO, and other styles

24

Pan, Xuewen, and Joseph Heitman. "Cyclic AMP-Dependent Protein Kinase Regulates Pseudohyphal Differentiation in Saccharomyces cerevisiae." Molecular and Cellular Biology 19, no. 7 (1999): 4874–87. http://dx.doi.org/10.1128/mcb.19.7.4874.

Full text

Abstract:

ABSTRACT In response to nitrogen starvation, diploid cells of the yeastSaccharomyces cerevisiae differentiate to a filamentous growth form known as pseudohyphal differentiation. Filamentous growth is regulated by elements of the pheromone mitogen-activated protein (MAP) kinase cascade and a second signaling cascade involving the receptor Gpr1, the Gα protein Gpa2, Ras2, and cyclic AMP (cAMP). We show here that the Gpr1-Gpa2-cAMP pathway signals via the cAMP-dependent protein kinase, protein kinase A (PKA), to regulate pseudohyphal differentiation. Activation of PKA by mutation of the regulator

APA, Harvard, Vancouver, ISO, and other styles

25

Welton, Robert M., та Charles S. Hoffman. "Glucose Monitoring in Fission Yeast via the gpa2 Gα, the git5 Gβ and the git3 Putative Glucose Receptor". Genetics 156, № 2 (2000): 513–21. http://dx.doi.org/10.1093/genetics/156.2.513.

Full text

Abstract:

Abstract The fission yeast Schizosaccharomyces pombe responds to environmental glucose by activating adenylate cyclase. The resulting cAMP signal activates protein kinase A (PKA). PKA inhibits glucose starvation-induced processes, such as conjugation and meiosis, and the transcription of the fbp1 gene that encodes the gluconeogenic enzyme fructose-1,6-bisphosphatase. We previously identified a collection of git genes required for glucose repression of fbp1 transcription, including pka1/git6, encoding the PKA catalytic subunit, git2/cyr1, encoding adenylate cyclase, and six “upstream” genes req

APA, Harvard, Vancouver, ISO, and other styles

26

Adamu, Sadiq, Ahmad Aliyu Deba, and Fatima Umar Zambuk. "Data Selection, Training, and Validation for Deployment of the Artificial Neural Networks to Predict Science Education Students’ Early Completion of University." International Journal of Scientific Research in Computer Science and Engineering 13, no. 1 (2025): 11–20. https://doi.org/10.26438/ijsrcse.v13i1.608.

Full text

Abstract:

Predicting student graduation helps schools identify students in danger of dropping out and intervene early to enhance academic performance. It can also assist educators and policymakers in creating graduation and dropout prevention initiatives. Nowadays, predicting students' performance is one of the most specific topics for learning environments, such as universities and schools, since it leads to the development of effective mechanisms that can enhance academic outcomes and avoid destruction. This study aims to (1) determine the datasets needed for the adaption/simulation of fresh undergrad

APA, Harvard, Vancouver, ISO, and other styles

27

Lorenz, Michael C., Xuewen Pan, Toshiaki Harashima, et al. "The G Protein-Coupled Receptor Gpr1 Is a Nutrient Sensor That Regulates Pseudohyphal Differentiation in Saccharomyces cerevisiae." Genetics 154, no. 2 (2000): 609–22. http://dx.doi.org/10.1093/genetics/154.2.609.

Full text

Abstract:

Abstract Pseudohyphal differentiation in the budding yeast Saccharomyces cerevisiae is induced in diploid cells in response to nitrogen starvation and abundant fermentable carbon source. Filamentous growth requires at least two signaling pathways: the pheromone responsive MAP kinase cascade and the Gpa2p-cAMP-PKA signaling pathway. Recent studies have established a physical and functional link between the Gα protein Gpa2 and the G protein-coupled receptor homolog Gpr1. We report here that the Gpr1 receptor is required for filamentous and haploid invasive growth and regulates expression of the

APA, Harvard, Vancouver, ISO, and other styles

28

Hoffman, C. S. "Glucose sensing via the protein kinase A pathway in Schizosaccharomyces pombe." Biochemical Society Transactions 33, no. 1 (2005): 257–60. http://dx.doi.org/10.1042/bst0330257.

Full text

Abstract:

The fission yeast Schizosaccharomyces pombe primarily detects glucose via a cAMP-signalling pathway. Components of this pathway include the Git3 G-protein-coupled receptor and a heterotrimeric G-protein, from which the Gpa2 Gα subunit activates adenylate cyclase (Git2/Cyr1). Three additional proteins, Git1, Git7 and Git10 are required to generate a cAMP response even in a strain expressing an activated form of Gpa2, which is capable of bypassing the loss of the GPCR and Gβγ dimer. Therefore, Git1, Git7 and Git10 either act in a G-protein-independent manner or are required to stabilize or assem

APA, Harvard, Vancouver, ISO, and other styles

29

Park, Young-Un, Hyangsuk Hur, Minhan Ka, and Jinmi Kim. "Identification of Translational Regulation Target Genes during Filamentous Growth in Saccharomyces cerevisiae: Regulatory Role of Caf20 and Dhh1." Eukaryotic Cell 5, no. 12 (2006): 2120–27. http://dx.doi.org/10.1128/ec.00121-06.

Full text

Abstract:

ABSTRACT The dimorphic transition of yeast to the hyphal form is regulated by the mitogen-activated protein kinase and cyclic AMP-dependent protein kinase A pathways in Saccharomyces cerevisiae. Signaling pathway-responsive transcription factors such as Ste12, Tec1, and Flo8 are known to mediate filamentation-specific transcription. We were interested in investigating the translational regulation of specific mRNAs during the yeast-to-hyphal-form transition. Using polyribosome fractionation and RT-PCR analysis, we identified STE12, GPA2, and CLN1 as translation regulation target genes during fi

APA, Harvard, Vancouver, ISO, and other styles

30

Lorenz, M. C. "Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog." EMBO Journal 16, no. 23 (1997): 7008–18. http://dx.doi.org/10.1093/emboj/16.23.7008.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Huang, Shan, Alex Benben, Robert Green та ін. "Phosphorylation of the Gα protein Gpa2 promotes protein kinase A signaling in yeast". Journal of Biological Chemistry 294, № 49 (2019): 18836–45. http://dx.doi.org/10.1074/jbc.ra119.009609.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Hausken, Krist N., Belen Tizon, Michal Shpilman, et al. "Cloning and characterization of a second lamprey pituitary glycoprotein hormone, thyrostimulin (GpA2/GpB5)." General and Comparative Endocrinology 264 (August 2018): 16–27. http://dx.doi.org/10.1016/j.ygcen.2018.04.010.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Wang, Ying, Michael Pierce, Lisa Schneper, et al. "Ras and Gpa2 Mediate One Branch of a Redundant Glucose Signaling Pathway in Yeast." PLoS Biology 2, no. 5 (2004): e128. http://dx.doi.org/10.1371/journal.pbio.0020128.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Al-Dailami, Areej N., Jimena Leyria, Ian Orchard, and Angela B. Lange. "Exploring the role of glycoprotein hormone GPA2/GPB5 in the medically important insect, Rhodnius prolixus." Peptides 149 (March 2022): 170710. http://dx.doi.org/10.1016/j.peptides.2021.170710.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Sacco, Melanie Ann, Kamila Koropacka, Eric Grenier, et al. "The Cyst Nematode SPRYSEC Protein RBP-1 Elicits Gpa2- and RanGAP2-Dependent Plant Cell Death." PLoS Pathogens 5, no. 8 (2009): e1000564. http://dx.doi.org/10.1371/journal.ppat.1000564.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Bakulina, A. V., L. S. Savintseva, O. N. Bashlakova, and N. F. Sintsova. "Molecular screening of potato varieties bred by Falenki Breeding station for resistance to phytopathogens." Agricultural Science Euro-North-East 22, no. 3 (2021): 340–50. http://dx.doi.org/10.30766/2072-9081.2021.22.3.340-350.

Full text

Abstract:

The genotypes of potatoes bred by Falenki Breeding station were studied for the presence of resistance genes markers to the following pathogens: Globodera rostochiensis, Globodera pallidа, Synchytrium endobioticum, potato virus X (PVХ) and potato virus Y (PVY). The method of multiplex PCR analysis was used. The varieties Shurminsky 2, Alisa, Viza, Chayka, Ognivo, Darik, Gloriya, Golubka, Virazh and a promising variety sample 56-09 were studied. In most (8 out of 10) genotypes, marker linked to the Sen1 gene of resistance to S. endobioticum was identified. DNA marker of the G. rostochiensis res

APA, Harvard, Vancouver, ISO, and other styles

37

Abe, Thomas Olabode. "Correlate of Grade Point Average (GPA) In Mathematics Among Undergraduate Students in Ekiti State." International Journal of Quantitative and Qualitative Research Methods 12, no. 2 (2024): 38–43. http://dx.doi.org/10.37745/ijqqrm.13/vol12n23843.

Full text

Abstract:

The study investigated the correlate of grade point average (GPA) in mathematics among undergraduate students in Ekiti State. The study employed ex-post facto, research design of survey type. The sample for the study was made up of one hundred and fifty (150) students which were randomly selected from different levels through stratified random sampling techniques in three (3) tertiary institutions in the state. A self-developed Performa was used as an instrument to collect data for the study. Three (3) hypotheses were formulated for the study and tested using Pearson product moment correlation

APA, Harvard, Vancouver, ISO, and other styles

38

Tando, Yukiko, та Kaoru Kubokawa. "A Homolog of the Vertebrate Thyrostimulin Glycoprotein Hormone α Subunit (GPA2) is Expressed in Amphioxus Neurons". Zoological Science 26, № 6 (2009): 409–14. http://dx.doi.org/10.2108/zsj.26.409.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Bennett, Richard J., and Alexander D. Johnson. "The role of nutrient regulation and the Gpa2 protein in the mating pheromone response ofC. albicans." Molecular Microbiology 62, no. 1 (2006): 100–119. http://dx.doi.org/10.1111/j.1365-2958.2006.05367.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Rocco, David A., and Jean-Paul V. Paluzzi. "Functional role of the heterodimeric glycoprotein hormone, GPA2/GPB5, and its receptor, LGR1: An invertebrate perspective." General and Comparative Endocrinology 234 (August 2016): 20–27. http://dx.doi.org/10.1016/j.ygcen.2015.12.011.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Ivey, F. D., and C. S. Hoffman. "Direct activation of fission yeast adenylate cyclase by the Gpa2 G of the glucose signaling pathway." Proceedings of the National Academy of Sciences 102, no. 17 (2005): 6108–13. http://dx.doi.org/10.1073/pnas.0502270102.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Aniszewska, Dorota, and Marek Rybaczuk. "Predicting the Young’s Modulus of Concrete Using a Particle-Based Movable Cellular Automata Method." Applied Sciences 15, no. 9 (2025): 4840. https://doi.org/10.3390/app15094840.

Full text

Abstract:

The elastic modulus is one of the fundamental parameters controlling the mechanical behaviour of concrete. In this study, the Movable Cellular Automata (MCA) method is applied to predict the Young’s modulus of concrete based on the properties of its components. Each automaton represents one component: cement paste, fine aggregate, or coarse aggregate. A parametric sensitivity analysis was performed using Grey System Theory (GST) on hypothetical concrete modeled with the MCA method. The analysis showed that the coarse aggregate type, coarse aggregate-to-total aggregate ratio, and water-to-cemen

APA, Harvard, Vancouver, ISO, and other styles

43

Stakheev, Alexander A., Denis V. Erokhin, Ekaterina A. Meleshchuk, Oleg D. Mikityuk, and Natalia V. Statsyuk. "Effect of Compactin on the Mycotoxin Production and Expression of Related Biosynthetic and Regulatory Genes in Toxigenic Fusarium culmorum." Microorganisms 10, no. 7 (2022): 1347. http://dx.doi.org/10.3390/microorganisms10071347.

Full text

Abstract:

Zearalenone (ZEN) and deoxynivalenol (DON) are mycotoxins produced by various species of Fusarium fungi. They contaminate agricultural products and negatively influence human and animal health, thus representing a serious problem of the agricultural industry. Earlier we showed that compactin, a secondary metabolite of Penicillium citrinum, is able to completely suppress the aflatoxin B1 biosynthesis by Aspergillus flavus. Using the F. culmorum strain FC-19 able to produce DON and ZEN, we demonstrated that compactin also significantly suppressed both DON (99.3%) and ZEN (100%) biosynthesis. The

APA, Harvard, Vancouver, ISO, and other styles

44

Sellami, Azza, Hans-Jürgen Agricola, and Jan A. Veenstra. "Neuroendocrine cells in Drosophila melanogaster producing GPA2/GPB5, a hormone with homology to LH, FSH and TSH." General and Comparative Endocrinology 170, no. 3 (2011): 582–88. http://dx.doi.org/10.1016/j.ygcen.2010.11.015.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Harashima, Toshiaki, та Joseph Heitman. "The Gα Protein Gpa2 Controls Yeast Differentiation by Interacting with Kelch Repeat Proteins that Mimic Gβ Subunits". Molecular Cell 10, № 1 (2002): 163–73. http://dx.doi.org/10.1016/s1097-2765(02)00569-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Papasawas, Savvas, Steve Arkinstall, John Reid та Mark Payton. "Yeast α-mating factor receptor and G-protein-linked adenylyl cyclase inhibition requires RAS2 and GPA2 activities". Biochemical and Biophysical Research Communications 184, № 3 (1992): 1378–85. http://dx.doi.org/10.1016/s0006-291x(05)80035-x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Лихненко, С. В. "Мониторинг устойчивости форм картофеля к основным болезням". ТЕНДЕНЦИИ РАЗВИТИЯ НАУКИ И ОБРАЗОВАНИЯ 92, № 14 (2022): 80–83. http://dx.doi.org/10.18411/trnio-12-2022-650.

Full text

Abstract:

Селекция картофеля в СКНИИГПСХ ведется в направлении создания столового сорта устойчивого к болезням и вредителям, с хозяйственно ценными качествами для региона Северного Кавказа с резко континентальным климатом. Ежегодно ведется поиск доноров устойчивых к основным опасным болезням: фитофторозу, альтернариозу, вирусным болезням, вироидам и к цистообразующим нематодам. В результате изучения выделена группа устойчивых форм к альтернариозу: Зорачка, Мисс Бланш, Колобок, 15.160/560, 87.759/3. Определена группа с полевой устойчивостью к вирусным болезням: Арсенал, Осетинский, Фарн, Терский. Диагнос

APA, Harvard, Vancouver, ISO, and other styles

48

Rocco, David A., Doo Hyun Kim, and Jean-Paul V. Paluzzi. "Immunohistochemical mapping and transcript expression of the GPA2/GPB5 receptor in tissues of the adult mosquito, Aedes aegypti." Cell and Tissue Research 369, no. 2 (2017): 313–30. http://dx.doi.org/10.1007/s00441-017-2610-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

van der Voort, J. Rouppe, P. Wolters, R. Folkertsma, et al. "Mapping of the cyst nematode resistance locus Gpa2 in potato using a strategy based on comigrating AFLP markers." Theoretical and Applied Genetics 95, no. 5-6 (1997): 874–80. http://dx.doi.org/10.1007/s001220050638.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Paluzzi, Jean-Paul, Mark Vanderveken, and Michael J. O’Donnell. "The Heterodimeric Glycoprotein Hormone, GPA2/GPB5, Regulates Ion Transport across the Hindgut of the Adult Mosquito, Aedes aegypti." PLoS ONE 9, no. 1 (2014): e86386. http://dx.doi.org/10.1371/journal.pone.0086386.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!