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Dissertations / Theses on the topic 'GPC-3'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Camargo, Luciana Amade [UNESP]. "Glicerol-3-Fosfato oxidase em levedura de panificação." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/88352.

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Made available in DSpace on 2014-06-11T19:23:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-05-04Bitstream added on 2014-06-13T20:30:10Z : No. of bitstreams: 1 camargo_la_me_arafcf.pdf: 458749 bytes, checksum: e566ad21072ed4474151776ec23f5806 (MD5)<br>Universidade Estadual Paulista (UNESP)<br>A presente dissertação permitiu quantificar a presença de glicerol-3-fosfato oxidase (GPO, sn-glicerol-3-fosfato: oxigênio 2-oxidorredutase, EC 1.1.3.21) em extratos de levedura seca de panificação por dois métodos: polarográfico e colorimétrico. A melhor metodologia de purificação da GPO foi

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Camargo, Luciana Amade. "Glicerol-3-Fosfato oxidase em levedura de panificação /." Araraquara : [s.n.], 2007. http://hdl.handle.net/11449/88352.

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Resumo: A presente dissertação permitiu quantificar a presença de glicerol-3-fosfato oxidase (GPO, sn-glicerol-3-fosfato: oxigênio 2-oxidorredutase, EC 1.1.3.21) em extratos de levedura seca de panificação por dois métodos: polarográfico e colorimétrico. A melhor metodologia de purificação da GPO foi obtida por rompimento celular com esferas de vidro, em homogenizador do tipo Bead Beater (Biospec products, USA), por 15 minutos, com 27,6% de eficiência de lise celular. O extrato celular bruto foi tratado com 1% de sulfato de estreptomicina antes da precipitação com igual volume de solução 30% (

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Faber, Antonia [Verfasser]. "Gravity wave analysis with GPS radio occultation data from FORMOSAT-3 / COSMIC / Antonia Faber. Deutsches GeoForschungsZentrum GFZ." Potsdam : Deutsches GeoForschungsZentrum GFZ, 2013. http://d-nb.info/1038685354/34.

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Zhang, Minze [Verfasser]. "Membrane Topology and Processing of Glycoprotein 3 (GP3) of Porcine Respiratory and Reproductive Syndrome Virus / Minze Zhang." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1170814689/34.

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5

Muñoz, Vergara Marcelo Alejandro. "Diseño e Implementación de un Visualizador de Equipos GPS en Mapas de 3 Dimensiones Utilizando Sistemas de Información Geográfica." Tesis, Universidad de Chile, 2008. http://repositorio.uchile.cl/handle/2250/103258.

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El objetivo general del presente trabajo de título es diseñar e implementar un visualizador de equipos GPS, que realice el rendering de un mapa (superficie) de 3 dimensiones utilizando un Sistema de Información Geográfica (GIS) como fuente de datos. Esta herramienta debe simplificar y optimizar la interacción entre el usuario y el servidor. Al momento de realizar este trabajo, no existían muchas aplicaciones que representen la información geográfica en 3 dimensiones, sin embargo se está presenciando un constante crecimiento de los GIS 3D y su interacción con los CAD (herramientas de di

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Bakari, Sana. "Expression de 3 protéines membranaires, CYP3A4, MGST1 et P-gp, impliquées dans la détoxication cellulaire." Paris 6, 2013. http://www.theses.fr/2013PA066717.

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Les xénobiotiques présents dans l’environnement peuvent être toxiques pour les organismes, et leurs effets restent difficiles à évaluer, en particulier à cause de synergies possibles entre eux. La voie cellulaire qui aboutit à l’élimination de ces xénobiotiques est un processus de détoxication mettant en place 3 systèmes enzymatiques spécialisés et complémentaires, principalement au niveau du foie. Il s’agit des monooxygénases, principalement des cytochromes P450 (phase I), des enzymes de conjugaison, ou transférases (phase II), et des protéines d'efflux actif (phase III). Les gènes codant pou

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Mohd, Suldi Azman Bin. "Investigations into un-mitigated troposphere and multipath effects on kinematic GPS for 3-dimensional monitoring of high rise buiding movements." Thesis, University of Nottingham, 2006. http://eprints.nottingham.ac.uk/13005/.

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Monitoring is a process of observing any changes on a monitored subject. Deformation monitoring is a process which consists of four stages: specification, design, implementation and analysis [Kennie et al., 1990], with the structure being monitored on a daily, hourly or continuous basis for any changes in position, size and shape. With the Global Positioning System (GPS), a 24-hour all weather monitoring system can be established. However, for kinematic GPS, un-mitigated troposphere and multipath remain as the main source of errors in the position residuals. These were investigated in detail u

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Grifi, Daniele. "Studio ed implementazione di algoritmi per la navigazione inerziale di velivoli autonomi ad ala rotante." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amslaurea.unibo.it/7528/.

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I sistemi di navigazione inerziale, denominati INS, e quelli di navigazione inerziale assistita, ovvero che sfruttano anche sensori di tipo non inerziale come ad esempio il GPS, denominati in questo caso INS/GPS, hanno visto un forte incremento del loro utilizzo soprattutto negli ultimi anni. I filtri complementari sfruttano segnali in ingresso che presentano caratteristiche complementari in termine di banda. Con questo lavoro di tesi mi sono inserito nel contesto del progetto SHERPA (Smart collaboration between Humans and ground-aErial Robots for imProving rescuing activities in Alpine enviro

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Gastebois, Amandine. "Protéines ancrées à la membrane plasmique par l'intermédiaire d'un Glycosylphosphatidylinositol (GPI) et modification des β(1-3)glucanes chez Aspergillus fumigatus". Paris 6, 2009. http://www.theses.fr/2009PA066431.

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La biosynthèse de la paroi cellulaire est un événement essentiel pour la croissance et le développement d’Aspergillus fumigatus. Les composants majoritaires de cette paroi sont les β(1-3)glucanes. Ceux-ci sont synthétisés au niveau de la membrane plasmique par un complexe transmembranaire puis modifiés dans l’espace pariétal. Des études antérieures ont montré que des transglycosidases pariétales, ancrées à la membrane plasmique par l’intermédiaire d’une ancre Glysosylphosphatidylinositol (GPI), jouent un rôle important dans l’organisation des polysaccharides de la paroi. Des analyses in silico

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Caldeira, Dany Roberta Marques. "Avaliação multiregional do modelo 3-GP e simulação de produtividade de eucalipto para o estado de Rondônia /." Botucatu, 2019. http://hdl.handle.net/11449/192620.

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Orientador: José Luiz Stape<br>Resumo: O Brasil é um dos líderes mundiais na produção de celulose, papel e painéis de madeira. Este sucesso se deve a diversos fatores, tais como: às condições edafoclimáticas favoráveis ao desenvolvimento de espécies de alto rendimento; aos investimentos nos setores de pesquisa e inovação; ao estabelecimento de parcerias entre empresas e instituições de pesquisa e ensino. Desde a chegada das primeiras árvores de eucalipto, no início do século XX, a produtividade da espécie e a quantidade de área plantada cresceram no país, por outro lado, a busca por melhorias

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Konkel, Anne. "Einfluss von Omega-3 Fettsäuren auf die Bildung physiologisch aktiver CYP-Eicosanoide." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2016. http://dx.doi.org/10.18452/17520.

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Mehrfach ungesättigte omega-3 Fettsäuren (n-3 PUFAs), wie Eicosapentaensäure (EPA) und Docosahexaensäure (DHA), schützen vor kardiovaskulären Erkrankungen, wie tödlichen Arrhythmien. In vitro Untersuchungen belegen, dass rekombinante Cytochrom P450 (CYP) Enzyme nicht nur die n-6 PUFA Arachidonsäure (AA), sondern auch die n-3 PUFAs EPA und DHA als alternative Substrate verwenden. Dabei entstehen bioaktive regio- und stereoisomere Epoxy- und Hydroxymetaboliten, CYP-Eicosanoide, die als sekundäre Botenstoffe bei der Regulation von Gefäß-, Nieren- und Herzfunktionen fungieren. Die genauen molekula

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Vignon, Christine. "Contrôle du métabolisme oxydatif des cellules leucémiques par le microenvironnement médullaire." Thesis, Tours, 2011. http://www.theses.fr/2011TOUR3315.

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Des études menées sur des modèles animaux ont montré que le métabolisme oxydatif joue un rôle important dans l’hématopoïèse normale et leucémique via le contrôle de l’activation de p38 MAPK. Nous avons établi que les cellules CD34+CD38- médullaires humaines ont un très faible niveau d’H2O2 et une forte expression de GPX3, le gène codant l’enzyme antioxydante glutathion peroxydase-3 (GPx-3), un déterminant majeur du potentiel souche des cellules hématopoïétiques. De plus, la niche leucémique étant essentielle pour l’auto-renouvellement des cellules souches leucémiques, nous avons étudié, chez l

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Arras, Christina [Verfasser]. "A global survey of sporadic E layers based on GPS radio occultations by CHAMP, GRACE and FORMOSAT–3 / COSMIC / Christina Arras. Deutsches GeoForschungsZentrum GFZ." Potsdam : Deutsches GeoForschungsZentrum GFZ, 2010. http://d-nb.info/1008996548/34.

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Ouellet, Stéphane. "Études des mécanismes de régulation de la transcription des gènes humains P21CIP1/WAF1, GPC3 (GLYPICAN 3) et A-beta-PP (AMYLOID beta-PRECURSOR PROTEIN)." Thesis, Université Laval, 2010. http://www.theses.ulaval.ca/2010/27537/27537.pdf.

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La connaissance des mécanismes qui contrôlent la transcription des gènes, comme l’interaction de facteurs protéiques au niveau des promoteurs, est essentielle pour comprendre plusieurs fonctions biologiques et espérer traiter certaines pathologies. Nous nous sommes attardés à mieux comprendre les mécanismes qui régulent trois gènes humains dont les patrons d’expression sont différents et qui sont impliqués dans diverses pathologies en tentant de mettre en parallèle les différences structurales et fonctionnelles entre ceux-ci. Les gènes AβPP et p21 sont exprimés chez l’adulte alors que GPC3 est

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Qiao, Wenbao. "GPU component-based neighborhood search for Euclidean graph minimization problems." Thesis, Bourgogne Franche-Comté, 2018. http://www.theses.fr/2018UBFCA020.

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Dans cette thèse, nous proposons des solutions parrallèles basées sur le systèmes actuel GPU (graphics processing unit) pour deux problèmes de minimisation de graphe Euclidien, à savoir le problème de forêt/arbre couvrant minimum Euclidien (EMSF / EMST) et le problème du voyageur commerce (TSP). Les solutions proposées résolvent également aussi le problème d'une paire bichromatique la plus proche (BCP), et suivent la technique de ``contrôle décentralisé, du parallélisme des données et des mémoires partagées par GPU".Nous proposons une technique de recherche dans le voisinage le plus proche de

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Aragón, Àngel Angela. "Contributions to ionospheric electron density retrieval." Doctoral thesis, Universitat Politècnica de Catalunya, 2010. http://hdl.handle.net/10803/77897.

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La transformada de Abel es una técnica de inversión usada frecuentemente en radio ocultaciones (RO) que, en el contexto ionosférico, permite deducir densidades electrónicas a partir de datos de STEC (Slant Total Electron Content) derivados a partir de observaciones de la fase portadora. Esta técnica está basada en medidas precisas en doble frecuencia de fase portadora ( banda L) de un receptor GPS a bordo de un satélite de órbita baja (Low Earth Orbit -LEO-) rastreando un satélite GPS detrás del limbo de la tierra. Al combinar tales medidas con la información de posiciones y velocidades de lo

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Akturk, Ozgur. "Assessment Of Tunnel Induced Deformation Field Through 3-dimensional Numerical Models (necatibey Subway Station, Ankara, Turkey)." Phd thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12612539/index.pdf.

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In heavily settled areas, deformations induced by the tunnel excavation may cause serious damage to nearby structures. In this study it is aimed to model ground deformations induced by main tunnels and connection tunnels excavations as well as groundwater drainage. Therefore, it is necessary to study effective means of controlling tunnel induced deformations. The main parameters affecting the failure and deformation state of the soil around a circular underground opening are the physical characteristics of the soil, the diameter of the opening, and the support pressure. During the construction

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Senate, University of Arizona Faculty. "Faculty Senate Minutes December 3, 2012." University of Arizona Faculty Senate (Tucson, AZ), 2012. http://hdl.handle.net/10150/269272.

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Balestri, Roberto. "Intelligenza artificiale e industrie culturali storia, tecnologie e potenzialità dell’ia nella produzione cinematografica." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2022. http://amslaurea.unibo.it/25176/.

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Negli ultimi anni stiamo assistendo, in svariati campi, a un sempre più vasto utilizzo di tecnologie che utilizzano quella che viene comunemente chiamata “intelligenza artificiale”. Anche il settore audiovisivo, da sempre recettore di novità e incline a evolversi continuamente, sta già vivendo quei processi che lo porteranno a essere rivoluzionato da questo tipo di tecnologie. In un periodo di frenetico progresso scientifico è difficile riuscire a fissare nel tempo e su carta lo stato attuale dello sviluppo tecnologico, dato che ciò che oggi viene considerato come novità domani potrebbe già

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Tsai, Yu-Ying, and 蔡玉嫈. "Equatorial waves observed using FORMOSAT-3 GPS Occultation." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/8d2n48.

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碩士<br>國立中央大學<br>太空科學研究所<br>96<br>Structure and propagation of equatorial atmospheric Kelvin waves and the latitudinal migration of intertropical convergence zone （ITCZ） during August 2006 and February 2008 are observed using FORMOSAT-3/COSMIC data. Zonal Kelvin wave derived from temperature fluctuations at 19 km characterize eastward phase propagation with the phase speed 2680 km/day, the wave periods are 12-17 days for zonal wave number 1 and 8-12 days for wave number 2. The vertical structure of Kelvin wave tilts eastward with height between 18-30 km, the phase propagates downward with the p

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Yeh, Hsiu-Pang, and 葉秀邦. "Using GPU to speed up 3-DES Computing." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/01864404055159069504.

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碩士<br>國立交通大學<br>資訊科學與工程研究所<br>97<br>Various cryptography algorithms have been developed to date to provide different levels of data security for application domains, such as storage security, personal identification, and secure web browsing. Although these algorithms do a very good job of protecting your privacy, they consume massive amount of resource on the server-side while processing encrypting and decrypting requests from clients. Generally speaking, a web server supporting transport security (TLS/SSL) could spend up to 60%~70% of its computing resource in encrypting and decrypting data a

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Lin, Ting-Jung, and 林廷融. "Temporal Gravity Changes from FORMOSAT-3 and GRACE GPS Tracking Data." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/98725633081021016379.

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博士<br>國立交通大學<br>土木工程學系<br>98<br>This dissertation is aimed at temporal gravity field recovery from the analyses of the high-low satellite-to-satellite tracking (hl-SST) data from the COSMIC and GRACE satellite missions. In order to estimate the time-varying geopotential coefficients, two efficient methodologies, the analytical orbital perturbation (AOP) approach and the residual acceleration (ACC) approach, are developed in the research. With the reference orbits removed, orbital perturbations (difference between kinematic and reference orbits) and residual accelerations (difference between ob

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Patlolla, Dilip Reddy. "A GPU-based Implementation for Improved Online Rebinning Performance in Clinical 3-D PET." 2009. http://trace.tennessee.edu/utk_gradthes/550.

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Online rebinning is an important and well-established technique for reducing the time required to process Positron Emission Tomography data. However, the need for efficient data processing in a clinical setting is growing rapidly and is beginning to exceed the capability of traditional online processing methods. High-count rate applications such as Rubidium 3-D PET studies can easily saturate current online rebinning technology. Realtime processing at these high-count rates is essential to avoid significant data loss. In addition, the emergence of time-of-flight (TOF) scanners is producing ver

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Luo, Wen-Quan, and 羅文泉. "The optimal path-planning for mobile vehicles with GPS on 3-D electronic maps." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/67236127886683944547.

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碩士<br>國立臺灣海洋大學<br>資訊工程學系<br>92<br>A novel path-planning method for mobile vehicles or stations among obstacles of arbitrary shape is presented. This method includes three parts. In the first part, a linear-interpolation scheme is introduced to create a database of three-dimensional electronic map based on a military map. In the second part, a Euclidean geometry scheme is applied to determine the light of sight that defines the relation of any pair of voxels. The last part, a higher geometry maze routing algorithm is introduced to conduct an optimal path-planning method in the workspace. The ob

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Lin, Jen-Chih, and 林荏志. "Tagging single-Nucleotide Polymorphisms in GPX-3 gene and susceptibility to Differentiated Thyroid Cancer." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/00458343512506935649.

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碩士<br>高雄醫學大學<br>醫學研究所碩士班<br>96<br>Introduction: Although the exact etiology of differentiated thyroid cancer (DTC) is not well understood, exposure to radiation is considered as a risk factor. Radiation can cause direct DNA damage and the generation of reactive oxygen species (ROS). In the thyroid, ROS and free radicals can participate in physiological and pathological processes. The antioxidant enzymes such as glutathione peroxidase (GPX), especially GPX3, can lower down the oxidative stress in thyrocyte. We want to find the relationship between the genetic variants of GPX3 and differentiated

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曾子榜. "Quantification of attitude error and signal propagation error in the GPS orbit determinatin of FORMOSAT-3/COSMIC." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/73633444649827132297.

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博士<br>國立交通大學<br>土木工程學系<br>98<br>The joint Taiwan-US mission FORMOSAT-3/COSMIC (F3/C) was launched on April 15, 2006. Each of the six satellites is equipped with two precise orbit determination (POD) antennas. The POD antennas of F3/C and GRACE-A satellites are from the same manufacturer, but are installed in different configurations. The LEO satellites are determined from GPS data using undifference carrier-phase measurements by the reduced dynamic and kinematic methods. This study compares the qualities of GPS observables from F3/C and GRACE. Using selected satellites and time spans, the foll

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Chiang, Chen-Ching, and 江振慶. "A simulation study on the use of GPS signals to infer 3-D atmospheric wet refractivity structure." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/62767323653526711969.

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碩士<br>國立中央大學<br>太空科學研究所<br>91<br>Atmospheric water vapor is a key variable in numerical weather prediction (NWP) models. On the other hand, it is a crucial factor to limit the accuracy of high-precision GPS positioning technique. For both issues, knowledge about the amount of water vapor is extremely important. In this study, we perform a simulation study to employ GPS signals through a developed tomographic scheme to retrieve 3D structure of atmospheric wet refractivity, which may be assimilated into NWP models for advancing forecasting or position calculation for improving GPS positioning ac

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Ching, Liaw Huang, and 廖凰卿. "GPS/GIS Applied on the Establishment of Potential Disaster Model for Tai-3 Highway in Southern Taiwan." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/79969759382158184322.

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碩士<br>國立屏東科技大學<br>土木工程系碩士班<br>92<br>The southern Tai-3 highway with 180 kilometers in length starts from PingTung City and runs north to the Meishan Xian in Jiayi county. It is one of the important traffic network in southern Taiwan. The studied section passes Meishanxian, Yujingxian, Nanhuaxian, Chishanxian, and Jiuzuxian where cover 12 township. The total length in the investigated section is approximately 165 kilometers. It runs through Terrace Deposits, Gutingkeng, Beiliao shale, Zhonglun, Toukoshan Hsiangshan Sandstone stratum and some other soft rock region in southern Taiwan. Weathering

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Rodriguez, Angel E. "Characterization of CAL 27 and HSC-3 cell lines. DPAGT1 gene expression and association with oral squamous cell carcinoma genesis and metastasis." Thesis, 2016. https://hdl.handle.net/2144/18669.

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Cancer, a disease of an uncontrolled cell division, growth and metastasis as a result of genetic mutations, environmental factors and host response, is affecting populations worldwide. Etiology, pathogenicity, and genetics related to cancer are not well understood, and treatment has not been as effective as scientists have expected. Continual research is being done to improve current understanding and treatments. Oral squamous cell carcinoma (OSCC) is one of the most common head and neck cancers (representing >90 % of all head and neck cancers) involving neoplasms of the oral cavity and or

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Jacobi, Ch, C. Arras, and J. Wickert. "Semidiurnal tidal signature over Collm (51.3N, 13E) in sporadic E layer frequency obtained from FORMOSAT-3/COSMIC GPS radio occultation measurements." 2008. https://ul.qucosa.de/id/qucosa%3A16103.

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We present measurements of sporadic E (Es) layer occurrence frequency from FORMOSAT-3/COSMIC GPS radio occultation measurements at 50°-55°N and compare these with zonal wind shears measured by meteor radar at Collm. Both parameters are, on a diurnal time scale, dominated by a semidiurnal oscillation. According to theory, maximum Es occurrence is expected when the zonal wind shear is negative. This is confirmed by our measurements and analyses.<br>Es werden Messungen sporadischer E-Schichten (Es) mit Hilfe von FORMOSAT- 3/COSMIC GPS-Radiookkultationsmessungen bei 50°-55°N vorgestellt und mit An

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Campion, Janine Margaret. "Climatic and nutritional controls on the growth of Eucalyptus grandis in South Africa." Thesis, 2006. http://hdl.handle.net/10539/1874.

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Student Number : 9402386H - PhD thesis - School of Animal, Plant and Environmental Sciences - Faculty of Science<br>The upper limit of forest production is constrained by the efficiency of radiation interception and the conversion of carbon dioxide into harvestable products, These processes are limited by water availability and nutrient supply. This study forms part of an international network of experiments aimed at demonstrating the potential yield of a forest species by eliminating water and nutrients as growth-limiting factors. The main aim of this study was to deter

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Ribeiro, Bruno Miguel Freitas. "Otimização do código de remoção de imagem fantasma utilizado na missão espacial Proba-3." Master's thesis, 2020. http://hdl.handle.net/1822/74437.

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Dissertação de mestrado integrado em Engenharia Eletrónica Industrial e Computadores<br>Esta dissertação surgiu no âmbito da missão espacial PROBA-3 da ESA. Esta missão tem como objetivo estudar em maior profundidade a coroa solar, com o intuito de obter dados importantes sobre o sol e os raios solares. Para realizar esta observação irão ser lançados dois satélites que irão realizar um trajeto em formação. Estes dois satélites irão formar um coronagraph, um instrumento utilizado para observar a coroa solar. Apesar deste instrumento já eliminar parte do ruído luminoso originado por outras

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Piccinotti, Jonas. "Fast GO/PO RCS calculation: A GO/PO parallel algorithm implemented on GPU and accelerated using a BVH data structure and the Type 3 Non-Uniform FFT." Tesi di dottorato, 2017. http://www.fedoa.unina.it/11888/1/Thesis.pdf.

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The purpose of this PhD research was to develop and optimize a fast numeric algorithm able to compute monostatic and bistatic RCS predictions obtaining an accuracy comparable to what commercially available from well-known electromagnetic CADs, but requiring unprecedented computational times. This was realized employing asymptotic approximated methods to solve the scattering problem, namely the Geometrical Optics (GO) and the Physical Optics (PO) theories, and exploiting advanced algorithmical concepts and cutting-edge computing technology to drastically speed-up the computation. The First C

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Khosravian, Alireza. "State Estimation for Systems on Lie Groups with Nonideal Measurements." Phd thesis, 2016. http://hdl.handle.net/1885/109348.

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This thesis considers the state estimation problem for invariant systems on Lie groups with inputs in its associated Lie algebra and outputs in homogeneous spaces of the Lie group. A particular focus of this thesis is the development of state estimation methodologies for systems with nonideal measurements, especially systems with additive input measurement bias, output measurement delay, and sampled outputs. The main contribution of the thesis is to effectively employ the symmetries of the system dynamics and to benefit from the Lie group structure of th

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Das, Mahua Rani. "Molecular characterization of glyceraldehyde-3-phosphate dehydrogenase from normal and malignant cells." Thesis, 2019. http://hdl.handle.net/10821/8236.

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Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key enzyme of glycolysis and increased glycolysis is a hallmark of malignancy. Previously we showed that methylglyoxal (MG), a normal metabolite, inhibits glycolysis. Moreover GAPDH, purified exclusively from different malignant cells, is a heterodimer (~90 kDa) containing two subunits of 33±2 and 55±3 kDa and is strongly inactivated by MG suggesting a distinct alteration of GAPDH in malignant cells, whereas GAPDH from normal sources is a homotetramer (~144 kDa), each subunit of 36 kDa. Here, by MALDI-TOF analysis, we report that the 55 kDa

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