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Relevant bibliographies by topics / GPC1

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Journal articles

Academic literature on the topic 'GPC1'

Author: Grafiati

Published: 1 April 2023

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Journal articles on the topic "GPC1"

1

Mucientes, A., E. Herranz, P. Lois, et al. "AB0077 CONTRIBUTION OF NOTUM TO THE DEVELOPMENT OF OSTEOARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1338.1–1339. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4569.

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Background:Osteoarthritis (OA) is a degenerative disease characterized by altered homeostasis of joint cartilage and bone, the functionality of which relies on chondrocytes and osteoblasts, that leads to the formation of a defective extracellular matrix (ECM). The ECM plays an essential role in bone biology as it provides the structure of cartilage which serves as a template for bone formation. Collagen X, main component of the ECM, has been described by our group as down-regulated in OA [1]. Our data also points to an important role of the Wnt pathway in OA [1,2]. Furthermore, Wnt proteins ha

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2

Wang, Shiqing, Zhenzhen Wu, Minyu Zhou, and Wangjun Liao. "Effect of GPC1 on epithelial-to-mesenchymal transition and stemness and interaction with ITGB1 in gastric cancer." Journal of Clinical Oncology 35, no. 15_suppl (2017): e15580-e15580. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e15580.

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e15580 Background: Gastric cancer is the fourth frequently diagnosed cancer worldwide and tumor metastasis plays an important role in its poor prognosis. EMT, which occurs during embryonic development and carcinoma progression, contributes to metastasis and regulates stemness. GPC1, a member of the heparan sulfate proteoglycans family, is overexpressed in many types of cancer, and associates with metastasis and tumor progression. However, it is unknown that the functions of GPC1 and its underlying mechanism in gastric cancer. Methods: Immunohistochemistry analysis was performed in 245 GC tissu

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3

Lu, Fei, Shuran Chen, Weijun Shi, Xu Su, Huazhang Wu та Mulin Liu. "GPC1 promotes the growth and migration of colorectal cancer cells through regulating the TGF-β1/SMAD2 signaling pathway". PLOS ONE 17, № 6 (2022): e0269094. http://dx.doi.org/10.1371/journal.pone.0269094.

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In this study, we analyzed GPC family genes in colorectal cancer (CRC) and the possible mechanism of action of GPC1 in CRC. CRC patient data were extracted from The Cancer Genome Atlas, and the prognostic significance of GPC1 expression and its association with clinicopathological features were identified by Kolmogorov–Smirnov test. CRC patients with high GPC1 expression had poor overall survival compared with patients with low GPC1 expression. In vitro experiments demonstrated that knockdown of GPC1 significantly inhibited the proliferation and migration and promoted cell apoptosis in CRC cel

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4

Qiao, Dianhua, Xinhai Yang, Kristy Meyer, and Andreas Friedl. "Glypican-1 Regulates Anaphase Promoting Complex/Cyclosome Substrates and Cell Cycle Progression in Endothelial Cells." Molecular Biology of the Cell 19, no. 7 (2008): 2789–801. http://dx.doi.org/10.1091/mbc.e07-10-1025.

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Glypican-1 (GPC1), a member of the mammalian glypican family of heparan sulfate proteoglycans, is highly expressed in glioma blood vessel endothelial cells (ECs). In this study, we investigated the role of GPC1 in EC replication by manipulating GPC1 expression in cultured mouse brain ECs. Moderate GPC1 overexpression stimulates EC growth, but proliferation is significantly suppressed when GPC1 expression is either knocked down or the molecule is highly overexpressed. Flow cytometric and biochemical analyses show that high or low expression of GPC1 causes cell cycle arrest at mitosis or the G2

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5

Qiao, Dianhua, Kristy Meyer, and Andreas Friedl. "Glypican 1 Stimulates S Phase Entry and DNA Replication in Human Glioma Cells and Normal Astrocytes." Molecular and Cellular Biology 33, no. 22 (2013): 4408–21. http://dx.doi.org/10.1128/mcb.00238-13.

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Malignant gliomas are highly lethal neoplasms with limited treatment options. We previously found that the heparan sulfate proteoglycan glypican 1 (GPC1) is universally and highly expressed in human gliomas. In this study, we investigated the biological activity of GPC1 expression in both human glioma cells and normal astrocytesin vitro. Expression of GPC1 inactivates the G1/S checkpoint and strongly stimulates DNA replication. Constitutive expression of GPC1 causes DNA rereplication and DNA damage, suggesting a mutagenic activity for GPC1. GPC1 expression leads to a significant downregulation

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6

Liu, Ying, Hui Ren, Mu-qing Yang, and Ji-yu Li. "GPC1 Is Associated with Poor Prognosis and Treg Infiltration in Colon Adenocarcinoma." Computational and Mathematical Methods in Medicine 2022 (September 14, 2022): 1–15. http://dx.doi.org/10.1155/2022/8209700.

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Glypican-1 (GPC1) is a glycosylated protein recognized as a promising biomarker for cancer. Nonetheless, there have been few systematic studies on GPC1 in colon adenocarcinoma (COAD). We conducted bioinformatic analysis based on The Cancer Genome Atlas (TCGA) and used clinical samples to verify that GPC1 is overexpressed in colon adenocarcinoma. Kaplan-Meier analysis showed that higher GPC1 expression was associated with poor overall survival (OS). The Cox regression model further showed that GPC1 expression is an independent negative prognostic factor for COAD. Gene set enrichment analysis de

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7

Schlaepfer Sales, Caroline B., Vanessa S. N. Guimarães, Ludmila F. Valverde, et al. "Glypican-1, -3, -5 (GPC1, GPC3, GPC5) and Hedgehog Pathway Expression in Oral Squamous Cell Carcinoma." Applied Immunohistochemistry & Molecular Morphology 29, no. 5 (2021): 345–51. http://dx.doi.org/10.1097/pai.0000000000000907.

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8

Whipple, Chery A., Arthur D. Lander, and Murray Korc. "Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis." Scientific World JOURNAL 8 (2008): 1250–53. http://dx.doi.org/10.1100/tsw.2008.152.

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The heparan sulfate proteoglycan, Glypican-1 (GPC1), significantly impacts the growth of pancreatic cancer cellsin vivoand markedly attenuates tumor angiogenesis and metastasis in athymic mice. Interestingly, both cancer cell–derived and host-derived GPC1 play an important role in tumor development and spread. These data suggest that GPC1 may be a valid therapeutic target for pancreatic cancer.

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9

Khurana, Satish, Chacko Joseph, Lia Margamuljana, Shannon Buckley, Sarah Scouteden, and Catherine M. Verfaillie. "Tissue Factor Pathway Inhibitor Increases Hematopoietic Stem Cell Homing and Engraftment by Glypican-3 Mediated Inhibition of CD26 Activity." Blood 118, no. 21 (2011): 725. http://dx.doi.org/10.1182/blood.v118.21.725.725.

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Abstract Abstract 725 Directional migration is an important factor that determines homing of transplanted hematopoietic stem cells (HSC). The SDF-1α-CXCR4 axis is one of the most important determinants of this process. CD26, expressed on various cell types, leads to proteolytic cleavage of SDF-1α, which leads to the inactivation of its chemokine activity. We identified tissue factor pathway inhibitor (TFPI) as an inhibitor of CD26. Culture of murine bone marrow derived c-kit+Lin−Sca-1+ (KLS) cells or human umbilical cord blood derived Lin−CD34+ cells with TFPI significantly inhibited CD26 acti

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10

Qiu, Wenli, Huifeng Zhang, Xiao Chen, et al. "A GPC1-targeted and gemcitabine-loaded biocompatible nanoplatform for pancreatic cancer multimodal imaging and therapy." Nanomedicine 14, no. 17 (2019): 2339–53. http://dx.doi.org/10.2217/nnm-2019-0063.

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Aim: Biomarker-targeted nanocarrier holds promise for early diagnosis and effective therapy of cancer. Materials & methods: This work successfully designs and evaluates GPC1-targeted, gemcitabine (GEM)-loaded multifunctional gold nanocarrier for near-infrared fluorescence (NIRF)/MRI and targeted chemotherapy against pancreatic cancer in vitro and in vivo. Results: Blood biochemical and histological analyses show that the in vivo toxicity of GPC1-GEM-nanoparticles (NPs) was negligible. Both in vitro and in vivo studies demonstrate that GPC1-GEM-NPs can be used as NIRF/MR contrast agent for

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