Relevant bibliographies by topics / GPCR

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'GPCR'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "GPCR"

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Vidad, Ashley Ryan, Stephen Macaspac, and Ho Leung Ng. "Locating ligand binding sites in G-protein coupled receptors using combined information from docking and sequence conservation." PeerJ 9 (September 24, 2021): e12219. http://dx.doi.org/10.7717/peerj.12219.

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GPCRs (G-protein coupled receptors) are the largest family of drug targets and share a conserved structure. Binding sites are unknown for many important GPCR ligands due to the difficulties of GPCR recombinant expression, biochemistry, and crystallography. We describe our approach, ConDockSite, for predicting ligand binding sites in class A GPCRs using combined information from surface conservation and docking, starting from crystal structures or homology models. We demonstrate the effectiveness of ConDockSite on crystallized class A GPCRs such as the beta2 adrenergic and A2A adenosine recepto
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Lin, Hsi-Hsien. "An Alternative Mode of GPCR Transactivation: Activation of GPCRs by Adhesion GPCRs." International Journal of Molecular Sciences 26, no. 2 (2025): 552. https://doi.org/10.3390/ijms26020552.

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G protein-coupled receptors (GPCRs), critical for cellular communication and signaling, represent the largest cell surface protein family and play important roles in numerous pathophysiological processes. Consequently, GPCRs have become a primary focus in drug discovery efforts. Beyond their traditional G protein-dependent signaling pathways, GPCRs are also capable of activating alternative signaling mechanisms, including G protein-independent signaling, biased signaling, and signaling crosstalk. A particularly novel signaling mode employed by these receptors is GPCR transactivation, which ena
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González-Guede, Irene, María López-Ramos, Luis Rodríguez-Rodríguez, Lydia Abasolo, Arkaitz Mucientes, and Benjamín Fernández-Gutiérrez. "Dysregulation of Glypicans and Notum in Osteoarthritis: Plasma Levels, Bone Marrow Mesenchymal Stromal Cells and Osteoblasts." Cells 13, no. 10 (2024): 852. http://dx.doi.org/10.3390/cells13100852.

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In this study of the alterations of Glypicans 1 to 6 (GPCs) and Notum in plasma, bone marrow mesenchymal stromal cells (BM-MSCs) and osteoblasts in Osteoarthritis (OA), the levels of GPCs and Notum in the plasma of 25 patients and 24 healthy subjects were measured. In addition, BM-MSCs from eight OA patients and eight healthy donors were cultured over a period of 21 days using both a culture medium and an osteogenic medium. Protein and gene expression levels of GPCs and Notum were determined using ELISA and qPCR at 0, 7, 14 and 21 days. GPC5 and Notum levels decreased in the plasma of OA patie
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Tany, Ryosuke, Yuhei Goto, Yohei Kondo, and Kazuhiro Aoki. "Quantitative live-cell imaging of GPCR downstream signaling dynamics." Biochemical Journal 479, no. 8 (2022): 883–900. http://dx.doi.org/10.1042/bcj20220021.

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G-protein-coupled receptors (GPCRs) play an important role in sensing various extracellular stimuli, such as neurotransmitters, hormones, and tastants, and transducing the input information into the cell. While the human genome encodes more than 800 GPCR genes, only four Gα-proteins (Gαs, Gαi/o, Gαq/11, and Gα12/13) are known to couple with GPCRs. It remains unclear how such divergent GPCR information is translated into the downstream G-protein signaling dynamics. To answer this question, we report a live-cell fluorescence imaging system for monitoring GPCR downstream signaling dynamics. Genet
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Baidya, Mithu, Punita Kumari, Hemlata Dwivedi-Agnihotri та ін. "Genetically encoded intrabody sensors report the interaction and trafficking of β-arrestin 1 upon activation of G-protein–coupled receptors". Journal of Biological Chemistry 295, № 30 (2020): 10153–67. http://dx.doi.org/10.1074/jbc.ra120.013470.

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Agonist stimulation of G-protein–coupled receptors (GPCRs) typically leads to phosphorylation of GPCRs and binding to multifunctional proteins called β-arrestins (βarrs). The GPCR–βarr interaction critically contributes to GPCR desensitization, endocytosis, and downstream signaling, and GPCR–βarr complex formation can be used as a generic readout of GPCR and βarr activation. Although several methods are currently available to monitor GPCR–βarr interactions, additional sensors to visualize them may expand the toolbox and complement existing methods. We have previously described antibody fragmen
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Chattopadhyay, Amitabha. "GPCRs: Lipid-Dependent Membrane Receptors That Act as Drug Targets." Advances in Biology 2014 (October 2, 2014): 1–12. http://dx.doi.org/10.1155/2014/143023.

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G protein-coupled receptors (GPCRs) are the largest class of molecules involved in signal transduction across cell membranes and represent major targets in the development of novel drug candidates in all clinical areas. Although there have been some recent leads, structural information on GPCRs is relatively rare due to the difficulty associated with crystallization. A specific reason for this is the intrinsic flexibility displayed by GPCRs, which is necessary for their functional diversity. Since GPCRs are integral membrane proteins, interaction of membrane lipids with them constitutes an imp
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Liu, Samuel, Preston J. Anderson, Sudarshan Rajagopal, Robert J. Lefkowitz, and Howard A. Rockman. "G Protein-Coupled Receptors: A Century of Research and Discovery." Circulation Research 135, no. 1 (2024): 174–97. http://dx.doi.org/10.1161/circresaha.124.323067.

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GPCRs (G protein-coupled receptors), also known as 7 transmembrane domain receptors, are the largest receptor family in the human genome, with ≈800 members. GPCRs regulate nearly every aspect of human physiology and disease, thus serving as important drug targets in cardiovascular disease. Sharing a conserved structure comprised of 7 transmembrane α-helices, GPCRs couple to heterotrimeric G-proteins, GPCR kinases, and β-arrestins, promoting downstream signaling through second messengers and other intracellular signaling pathways. GPCR drug development has led to important cardiovascular therap
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Kapolka, Nicholas J., Jacob B. Rowe, Geoffrey J. Taghon, William M. Morgan, Corin R. O’Shea, and Daniel G. Isom. "Proton-gated coincidence detection is a common feature of GPCR signaling." Proceedings of the National Academy of Sciences 118, no. 28 (2021): e2100171118. http://dx.doi.org/10.1073/pnas.2100171118.

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The evolutionary expansion of G protein-coupled receptors (GPCRs) has produced a rich diversity of transmembrane sensors for many physical and chemical signals. In humans alone, over 800 GPCRs detect stimuli such as light, hormones, and metabolites to guide cellular decision-making primarily using intracellular G protein signaling networks. This diversity is further enriched by GPCRs that function as molecular sensors capable of discerning multiple inputs to transduce cues encoded in complex, context-dependent signals. Here, we show that many GPCRs are coincidence detectors that couple proton
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Southern, Craig, Jennifer M. Cook, Zaynab Neetoo-Isseljee та ін. "Screening β-Arrestin Recruitment for the Identification of Natural Ligands for Orphan G-Protein–Coupled Receptors". Journal of Biomolecular Screening 18, № 5 (2013): 599–609. http://dx.doi.org/10.1177/1087057113475480.

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A variety of G-protein–coupled receptor (GPCR) screening technologies have successfully partnered a number of GPCRs with their cognate ligands. GPCR-mediated β-arrestin recruitment is now recognized as a distinct intracellular signaling pathway, and ligand-receptor interactions may show a bias toward β-arrestin over classical GPCR signaling pathways. We hypothesized that the failure to identify native ligands for the remaining orphan GPCRs may be a consequence of biased β-arrestin signaling. To investigate this, we assembled 10 500 candidate ligands and screened 82 GPCRs using PathHunter β-arr
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Ju, Man-Seok, and Sang Taek Jung. "Antigen Design for Successful Isolation of Highly Challenging Therapeutic Anti-GPCR Antibodies." International Journal of Molecular Sciences 21, no. 21 (2020): 8240. http://dx.doi.org/10.3390/ijms21218240.

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G-protein-coupled receptors (GPCR) transmit extracellular signals into cells to regulate a variety of cellular functions and are closely related to the homeostasis of the human body and the progression of various types of diseases. Great attention has been paid to GPCRs as excellent drug targets, and there are many commercially available small-molecule chemical drugs against GPCRs. Despite this, the development of therapeutic anti-GPCR antibodies has been delayed and is challenging due to the difficulty in preparing active forms of GPCR antigens, resulting from their low cellular expression an
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Dissertations / Theses on the topic "GPCR"

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Blankenship, Elise. "Conserved solvent networks in GPCR activation." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1458221506.

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Poudel, Sagar. "GPCR-Directed Libraries for High Throughput Screening." Thesis, University of Skövde, School of Humanities and Informatics, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-29.

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<p>Guanine nucleotide binding protein (G-protein) coupled receptors (GPCRs), the largest receptor family, is enormously important for the pharmaceutical industry as they are the target of 50-60% of all existing medicines. Discovery of many new GPCR receptors by the “human genome project”, open up new opportunities for developing novel therapeutics. High throughput screening (HTS) of chemical libraries is a well established method for finding new lead compounds in drug discovery. Despite some success this approach has suffered from the near absence of more focused and specific targeted librarie
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Majin, Wodu. "Mathematical modelling of GPCR-mediated calcium signalling." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12451/.

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Ca2+ is an important messenger which mediates several physiological functions, including muscle contraction, fertilisation, heart regulation and gene transcription. One major way its cytosolic level is raised is via a G-protein coupled receptor (GPCR)- mediated release from intracellular stores. GPCR’s are the target of approximately 50% of all drugs in clinical use. Hence, understanding the underlying mechanisms of signalling in this pathway could lead to improved therapy in disease conditions associated with abnornmal Ca2+ signalling, and to the identification of new drug targets. To gain su
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Tang, Lisa Sarah. "GPCR expressions in Saccharomyces cerevisiae : engineering transductions." Thesis, University of Leeds, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423190.

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Mishra, Satyakam. "Frequent Subgraph Mining Analysis of GPCR Activation." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1613575702373053.

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Kiess, Alexandra. "Funktionelle Relevanz intrazellulärer Splicevarianten des Brain-specific Angiogenesis Inhibitor 2 (BAI2)." Doctoral thesis, Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-156171.

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BAI2 gehört zu den Adhesion-G-Protein-gekoppelten Rezeptoren (aGPCR). Diese bisher wenig untersuchte Klasse von ca. 30 GPCR ist charakterisiert durch eine komplexe genomische Struktur, sehr große extrazelluläre Domänen und eine Vielzahl von Splicevarianten. Bisher ist bei den meisten aGPCR, wie auch bei BAI2, wenig über ihre Signaltransduktion und Funktion bekannt. Zum Verständnis der physiologischen Relevanz und zur Suche nach dem endogenen Agonist sind Kenntnisse über Proteinstruktur, Splicevarianten und Signaltransduktion essentiell. Ziel dieser Arbeit war es, mittels verschiedener in
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Sladek, Barbara. "Structural studies of integral membrane GPCR accessory proteins." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:09bf7ada-8e58-49f4-a979-bcd0cec95e8b.

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GPCR accessory proteins regulate the strength, efficiency and specificity of signal transfer upon receptor activation. Due to the inherent difficulties of studying membrane proteins in vitro and in vivo, little is known about the structure and topology of these small accessory proteins. Two examples of GPCR accessory proteins are the Melanocortin-2 receptor accessory protein (MRAP) and the Receptor-activity-modifying protein (RAMP) family. MRAP and RAMP1 are the main focus of this thesis in which they are thoroughly characterised by solution-state NMR and further biophysical techniques. The si
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Richardson, Kathryn. "Mechanisms of GPCR signal regulation in fission yeast." Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/63554/.

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Cells communicate with each other and respond to environmental cues by sending and receiving signals. Many external signals (ligands) are detected through G protein-coupled receptors (GPCRs), a major class of transmembrane proteins. GPCRs transduce these external signals into appropriate intracellular responses, enabling the cell to adapt to its environment. Malfunctions in these signalling pathways can lead to a range of human diseases and hence GPCRs have become attractive candidates for pharmacological design. The activation of a single receptor has the ability to induce numerous intracellu
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Goddard, Alan David. "Functional analysis of GPCR signalling cascades in Schizosaccharomyces pombe." Thesis, University of Warwick, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437696.

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Koyama, Hiroyuki. "Comprehensive Profiling of GPCR Expression in Ghrelin-producing Cells." Kyoto University, 2016. http://hdl.handle.net/2433/215953.

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Books on the topic "GPCR"

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Gilchrist, Annette, ed. GPCR Molecular Pharmacology and Drug Targeting. John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470627327.

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Heifetz, Alexander, ed. Computational Methods for GPCR Drug Discovery. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7465-8.

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Dupré, Denis J., Terence E. Hébert, and Ralf Jockers, eds. GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity. Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-4765-4.

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Annette, Gilchrist, ed. GPCR molecular pharmacology and drug targeting: Shifting paradigms and new directions. Wiley, 2010.

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Yona, Simon, and Martin Stacey, eds. Adhesion-GPCRs. Springer US, 2010. http://dx.doi.org/10.1007/978-1-4419-7913-1.

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Strasser, Andrea, and Hans-Joachim Wittmann. Modelling of GPCRs. Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-4596-4.

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Lebon, Guillaume, ed. Structure and Function of GPCRs. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-24591-7.

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Strasser, Andrea. Modelling of GPCRs: A Practical Handbook. Springer Netherlands, 2013.

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S, Baker Gregory, and Jol H. M, eds. Stratigraphic analyses using GPR. Geological Society of America, 2007.

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Bourne, H., R. Horuk, J. Kuhnke, and H. Michel, eds. GPCRs: From Deorphanization to Lead Structure Identification. Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-48982-5.

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Book chapters on the topic "GPCR"

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Manji, Husseini K., Jorge Quiroz, R. Andrew Chambers, et al. "GPCR." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_1464.

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Jones, Roger D., and Alan M. Jones. "A Proposed Mechanism for in vivo Programming Transmembrane Receptors." In Communications in Computer and Information Science. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-57430-6_11.

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AbstractTransmembrane G-protein coupled receptors (GPCRs) are ideal drug targets because they resemble, in function, molecular microprocessors for which outcomes (e.g. disease pathways) can be controlled by inputs (extracellular ligands). The inputs here are ligands in the extracellular fluid and possibly chemical signals from other sources in the cellular environment that modify the states of molecular switches, such as phosphorylation sites, on the intracellular domains of the receptor. Like in an engineered microprocessor, these inputs control the configuration of output switch states that
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Wu, Yiran, Jiahui Tong, Kang Ding, Qingtong Zhou, and Suwen Zhao. "GPCR Allosteric Modulator Discovery." In Advances in Experimental Medicine and Biology. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8719-7_10.

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Strasser, Andrea, and Hans-Joachim Wittmann. "Special Topics in GPCR Research." In Modelling of GPCRs. Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-4596-4_8.

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Knapp, Barbara, and Uwe Wolfrum. "Adhesion GPCR-Related Protein Networks." In Adhesion G Protein-coupled Receptors. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-41523-9_8.

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Butcher, Adrian J., Andrew B. Tobin, and Kok Choi Kong. "Examining Site-Specific GPCR Phosphorylation." In Methods in Molecular Biology. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-126-0_12.

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Gilchrist, Annette, and Maria R. Mazzoni. "Traditional GPCR Pharmacology and Beyond." In Signal Transduction: Pathways, Mechanisms and Diseases. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-02112-1_1.

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Miljus, Tamara, David A. Sykes, Clare R. Harwood, Ziva Vuckovic, and Dmitry B. Veprintsev. "GPCR Solubilization and Quality Control." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0373-4_8.

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Zhao, Qi, Amanda Chapman, Yan Huang, et al. "Ligand-Directed GPCR Antibody Discovery." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-1811-0_19.

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Grinde, Ellinor, and Katharine Herrick-Davis. "Class A GPCR: Serotonin Receptors." In G-Protein-Coupled Receptor Dimers. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-60174-8_6.

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Conference papers on the topic "GPCR"

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Ivanco, Thomas, Martin Sekula, Robert Thornburgh, and Andrew Kreshock. "Use of Generalized Predictive Control for Flutter Suppression of the Tiltrotor Aeroelastic System Testbed (TRAST)." In Vertical Flight Society 81st Annual Forum and Technology Display. The Vertical Flight Society, 2025. https://doi.org/10.4050/f-0081-2025-350.

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Generalized Predictive Control (GPC) is an advanced form of an adaptive control algorithm that uses experimentally acquired data to determine the input-output relationship of complex systems through a process called system identification. GPC has historically been employed for stability augmentation and vibration reduction of dynamically-scaled tiltrotor aircraft wind-tunnel models since the complex nature of these dynamic systems does not lend itself well to traditional control approaches. The present research expands upon previous analytical and experimental work with wind-tunnel experiments
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Xie, X. "GPCR-targeted drug discovery." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3399677.

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Sadova, A. A., D. A. Dmitrieva, N. A. Safronova, et al. "PREPARATION OF GPCR ANTIBODY COMPLEX SAMPLES FOR CRYO-ELECTRON MICROSCOPY." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-211.

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G-protein-coupled receptors are extremely important therapeutic targets, and their study represents the primary task of modern structural biology. Obtaining GPCR structures is fraught with many difficulties, which can be overcome by the formation of receptor and antibody fragments complexes. In this work, we obtained 4 antibody fragments, previously successfully used for the determination of GPCR structures, which we plan to use in the future to solve structures of the receptors studied in our laboratory.
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Bekhouche, Safia, and Yamina Mohamed Ben Ali. "Optimizing the identification of GPCR function." In SMC '19: The Second Conference of the Moroccan Classification Society. ACM, 2019. http://dx.doi.org/10.1145/3314074.3314082.

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Fang, Ye, Anthony G. Frutos, and Joydeep Lahiri. "G protein-coupled receptor (GPCR) microarrays." In International Symposium on Biomedical Optics, edited by Darryl J. Bornhop, David A. Dunn, Raymond P. Mariella, Jr., et al. SPIE, 2002. http://dx.doi.org/10.1117/12.472073.

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Robleto, Valeria, Ya Zhuo, Joseph Crecelius, and Adriano Marchese. "Regulation of GPCR Signaling by Sorting Nexins." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.276700.

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Franchini, Luca, Lindsay R. Watkins, and Cesare Orlandi. "Enhanced cAMP-based assay for GPCR deorphanization." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.148500.

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Qiu, Wang-Ren, Xuan Xiao, and Zhen-Yu Zhang. "Using AdaboostSVM to Predict the GPCR Functional Classes." In 2010 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2010. http://dx.doi.org/10.1109/icbbe.2010.5515639.

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WÜTHRICH, KURT. "STUDIES OF GPCR CONFORMATIONS IN NON-CRYSTALLINE MILIEUS." In 23rd International Solvay Conference on Chemistry. WORLD SCIENTIFIC, 2014. http://dx.doi.org/10.1142/9789814603836_0026.

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ROTH, BRYAN L. "THE HIDDEN PHARMACOLOGY OF THE HUMAN GPCR-OME." In 23rd International Solvay Conference on Chemistry. WORLD SCIENTIFIC, 2014. http://dx.doi.org/10.1142/9789814603836_0029.

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Reports on the topic "GPCR"

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ฤทธิ์ประจักษ์, พัชรี, та ประสิทธิ์ ภวสันต์. ผลของแรงเชิงกลต่อการเกิดการละลายภายในคลองรากฟันและ การพัฒนาแนวทางในการรักษา : รายงานความก้าวหน้าผลการดำเนินงานปีที่ 1. จุฬาลงกรณ์มหาวิทยาลัย, 2014. https://doi.org/10.58837/chula.res.2014.11.

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การบาดเจ็บจากแรงเชิงกลส่งผลให้เกิดการละลายภายในคลองรากฟัน ซึ่งเป็นปัญหาหนึ่งของการสูญเสียฟัน ดังนั้นการศึกษากลไกการเกิดการละลายภายในคลองรากฟันจึงมีผลต่อการพัฒนาแนวทางในการรักษาผู้ป่วยทางคลินิก ในงานวิจัยนี้คณะผู้วิจัยจึงมีวัตถุประสงค์หลักในการศึกษากลไกการเกิดการละลายภายในคลองรากฟัน โดยคณะผู้วิจัยมีสมมุติฐานเบื้องต้นว่าความเครียดจากแรงเชิงกล ส่งผลให้เกิดการอักเสบของเซลล์โพรงฟัน ทำให้เซลล์โพรงฟันหลั่งสารที่มีผลต่อการแปรสภาพและการทำงานของเซลล์สลายกระดูก/สลายฟัน ซึ่งเซลล์ดังกล่าวนี้จะไปทำลายเนื้อฟันและทำให้เกิดลักษณะทางคลินิกของการละลายภายในคลองรากฟัน จากผลการทดลองพบว่าเมื่อเซลล์โพรงฟันได้รับความเ
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Rafaeli, Ada, Russell Jurenka, and Daniel Segal. Isolation, Purification and Sequence Determination of Pheromonotropic-Receptors. United States Department of Agriculture, 2003. http://dx.doi.org/10.32747/2003.7695850.bard.

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Moths constitute a major group of pest insects in agriculture. Pheromone blends are utilised by a variety of moth species to attract conspecific mates, which is under circadian control by the neurohormone, PBAN (pheromone-biosynthesis-activating neuropeptide). Our working hypothesis was that, since the emission of sex-pheromone is necessary to attract a mate, then failure to produce and emit pheromone is a potential strategy for manipulating adult moth behavior. The project aimed at identifying, characterising and determining the sequence of specific receptors responsible for the interaction w
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O'Brien, Beth A., Chee Soon Tan, and Luca Onnis. Technology-based tools for teaching early literacy skills. National Institute of Education, Nanyang Technological University, Singapore, 2024. https://doi.org/10.32658/10497/27453.

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This project focuses on improving literacy development for young learners who are struggling with learning to read English by investigating the process of learning grapheme-phoneme correspondences (GPCs). Learning GPC is foundational to learning to read alphabetic languages, and is a core problem for struggling readers. In this project, two methods are used in two studies to understand the process of learning English GPCs as the crux of acquiring literacy. First, a machine learning neural network modelling approach is used to study the effect of sound-symbol grain size and consistency and trai
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Campos, D. Ground penetrating radar (GPR) methods. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 2012. http://dx.doi.org/10.4095/291772.

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Karp, Brad, and H. T. Kung. GPSR: Greedy Perimeter Stateless Routing for Wireless Networks. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada440078.

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Dubcovsky, Jorge, Tzion Fahima, and Ann Blechl. Positional cloning of a gene responsible for high grain protein content in tetraploid wheat. United States Department of Agriculture, 2003. http://dx.doi.org/10.32747/2003.7695875.bard.

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High Grain Protein Content (GPC) is a desirable trait in breadmaking and pasta wheat varieties because of its positive effects on quality and nutritional value. However, selection for GPC is limited by our poor understanding of the genes involved in the accumulation of protein in the grain. The long-term goal of this project is to provide a better understanding of the genes controlling GPC in wheat. The specific objectives of this project were: a) to develop a high-density genetic map of the GPC gene in tetraploid wheat, b) to construct a T. turgidum Bacterial Artificial Chromosome (BAC) libra
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Nelson, S. D. EM modeling for GPIR using 3D FDTD modeling codes. Office of Scientific and Technical Information (OSTI), 1994. http://dx.doi.org/10.2172/93462.

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Cook, Samantha, Marissa Torres, Nathan Lamie, Lee Perren, Scott Slone, and Bonnie Jones. Automated ground-penetrating-radar post-processing software in R programming. Engineer Research and Development Center (U.S.), 2022. http://dx.doi.org/10.21079/11681/45621.

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Ground-penetrating radar (GPR) is a nondestructive geophysical technique used to create images of the subsurface. A major limitation of GPR is that a subject matter expert (SME) needs to post-process and interpret the data, limiting the technique’s use. Post-processing is time-intensive and, for detailed processing, requires proprietary software. The goal of this study is to develop automated GPR post-processing software, compatible with Geophysical Survey Systems, Inc. (GSSI) data, in open-source R programming. This would eliminate the need for an SME to process GPR data, remove proprietary s
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Dubcovsky, Jorge, Tzion Fahima, Ann Blechl, and Phillip San Miguel. Validation of a candidate gene for increased grain protein content in wheat. United States Department of Agriculture, 2007. http://dx.doi.org/10.32747/2007.7695857.bard.

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High Grain Protein Content (GPC) of wheat is important for improved nutritional value and industrial quality. However, selection for this trait is limited by our poor understanding of the genes involved in the accumulation of protein in the grain. A gene with a large effect on GPC was detected on the short arm of chromosome 6B in a Triticum turgidum ssp. dicoccoides accession from Israel (DIC, hereafter). During the previous BARD project we constructed a half-million clones Bacterial Artificial Chromosome (BAC) library of tetraploid wheat including the high GPC allele from DIC and mapped the G
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Alonso-Alvarez, Irma, Marina Diakonova, and Javier J. Pérez. Rethinking GPR: The sources of geopolitical risk. Banco de España, 2025. https://doi.org/10.53479/39685.

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Geopolitical risks and tensions are nowadays regularly presented by policymakers and analysts as key conditioning factors of economic activity in both the short and the medium-run. Widely accepted operational measures of geopolitical risks tend to be based on counting the number of newspaper articles related to adverse geopolitical events, in particular following the ground-breaking paper of Caldara and Iacoviello (2022) in which they build their Geopolitical Risk (GPR) indexes. In this paper we propose one avenue to make further progress in the measurement of such risks. We provide a decompos
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