Academic literature on the topic 'Gr. 12'

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Journal articles on the topic "Gr. 12"

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Quax, R. A. M., J. A. M. van Laar, R. van Heerebeek, K. Greiner, E. Ben-Chetrit, M. Stanford, G. R. Wallace, et al. "Glucocorticoid sensitivity in Behçet's disease." Endocrine Connections 1, no. 2 (November 2012): 103–11. http://dx.doi.org/10.1530/ec-12-0056.

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ObjectiveGlucocorticoid (GC) sensitivity is highly variable among individuals and has been associated with susceptibility to develop (auto-)inflammatory disorders. The purpose of the study was to assess GC sensitivity in Behçet's disease (BD) by studying the distribution of four GC receptor (GR) gene polymorphisms and by measuring in vitro cellular GC sensitivity.MethodsHealthy controls and patients with BD in three independent cohorts were genotyped for four functional GR gene polymorphisms. To gain insight into functional differences in in vitro GC sensitivity, 19 patients with BD were studied using two bioassays and a whole-cell dexamethasone-binding assay. Finally, mRNA expression levels of GR splice variants (GR-α and GR-β) were measured.ResultsHealthy controls and BD patients in the three separate cohorts had similar distributions of the four GR polymorphisms. The Bcll and 9β minor alleles frequency differed significantly between Caucasians and Mideast and Turkish individuals.At the functional level, a decreased in vitro cellular GC sensitivity was observed. GR number in peripheral blood mononuclear cells was higher in BD compared with controls. The ratio of GR-α/GR-β mRNA expression levels was significantly lower in BD.ConclusionsPolymorphisms in the GR gene are not associated with susceptibility to BD. However, in vitro cellular GC sensitivity is decreased in BD, possibly mediated by a relative higher expression of the dominant negative GR-β splice variant. This decreased in vitro GC sensitivity might play an as yet unidentified role in the pathophysiology of BD.
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Vardy, Janette L., Haryana M. Dhillon, Gregory Russell Pond, Sean Rourke, Wei Xu, Corrinne Renton, Anna Dodd, Philip James Beale, Stephen John Clarke, and Ian Tannock. "Cognitive function and fatigue in colorectal cancer (CRC) patients: A prospective longitudinal controlled study." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 9021. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.9021.

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9021 Background: A subset of cancer patients has cognitive impairment and fatigue after chemotherapy (CTh). We evaluated these symptoms and potential mechanisms in CRC patients and healthy controls (HC). Methods: Cognitive function was evaluated in CRC patients and HC at baseline (pre-CTh), 6 and 12 months. Group 1A (Stage II/III) received CTh and Gr 1B (Stage I/II) no CTh. Gr 2 had limited metastatic CRC. All subjects completed cognitive assessment and questionnaires for fatigue, QOL, anxiety/depression, and perceived cognitive function. Blood tests evaluated: 10 cytokines, clotting factors, sex hormones, CEA, CBC and apolipoprotein genotyping as potential causal factors. Primary endpoints: cognitive function and fatigue (Gr. 1A & 1B) at 12 months. Associations between results and demographic and disease-related factors were sought. Results: 359 CRC patients (173 Gr 1A, 116 Gr 1B, 70 Gr. 2) and 72 HC were assessed. Median age 58 (23-75 years); 58% male. Cognitive impairment: baseline Gr 1A 34% vs 1B 32.5% (p=.9), Gr 1 33% vs HC 10% (p<0.001); 12 months Gr 1A 21% vs 1B 16% (p=0.43), Gr 1 19% vs HC 2% (p=0.001). Cognitive domains most affected: verbal & visual memory, processing speed. Men had greater impairment than women (p<0.009). Cognitive decline from 0-12 months: Gr 1A 30%, Gr 1B 19%, Gr 2 24%, and HC 16%. Perceived cognitive impairment at 12 months: Gr 1A 19% vs 1B 7% (p=.04), Gr 1 14% vs HC 0% (p=.009). Fatigue was greatest in Gr 1A (70%) at 6 months; at 12 months Gr. 1A 46% vs 1B 31% (p=0.056), Gr 2 60%, HC 36%. Cytokines were elevated in CRC patients compared to HC. No association was found with cognitive function and: fatigue, QOL, anxiety/depression, cytokines, sex hormones, clotting factors, CEA or apoE genotype. Objective cognitive function was associated with perceived cognitive function at baseline only. Fatigue at baseline was associated with hemoglobin and at 12 months with neutrophil count. Conclusions: Compared to HC, CRC patients had more cognitive impairment at baseline, 6 and 12 months; but impairment was not significantly different between those who did and did not receive CTh. The mechanisms of cognitive impairment remain unknown. Fatigue improved with time.
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Hooker, P. "12 The conferences." Greece and Rome 50, Supplement 1 (October 1, 2003): 169–82. http://dx.doi.org/10.1093/gr/50.suppl_1.169.

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Ramamoorthy, Sivapriya, and John A. Cidlowski. "Ligand-Induced Repression of the Glucocorticoid Receptor Gene Is Mediated by an NCoR1 Repression Complex Formed by Long-Range Chromatin Interactions with Intragenic Glucocorticoid Response Elements." Molecular and Cellular Biology 33, no. 9 (February 19, 2013): 1711–22. http://dx.doi.org/10.1128/mcb.01151-12.

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Glucocorticoids are among the most potent and effective agents for treating inflammatory diseases and hematological cancers. However, subpopulations of patients are often resistant to steroid therapy, and determining the molecular mechanisms that contribute to glucocorticoid resistance is thus critical to addressing this clinical problem affecting patients with chronic inflammatory disorders. Since the cellular level of the glucocorticoid receptor (GR) is a critical determinant of glucocorticoid sensitivity and resistance, we investigated the molecular mechanisms mediating repression of glucocorticoid receptor gene expression. We show here that glucocorticoid-induced repression of GR gene expression is mediated by inhibition of transcription initiation. This process is orchestrated by the recruitment of agonist-bound GR to exon 6, followed by the assembly of a GR-NCoR1-histone deacetylase 3-containing repression complex at the transcriptional start site of the GR gene. A functional negative glucocorticoid response element (nGRE) in exon 6 of the GR gene and a long-range interaction occurring between this intragenic response element and the transcription start site appear to be instrumental in this repression. This autoregulatory mechanism of repression implies that the GR concentration can coordinate repression with excess ligand, regardless of the combinatorial associations of tissue-specific transcription factors. Consequently, the chronic nature of inflammatory conditions involving long-term glucocorticoid administration may lead to constitutive repression of GR gene transcription and thus to glucocorticoid resistance.
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Young, Bryan G., David J. Gibson, Karla L. Gage, Joseph L. Matthews, David L. Jordan, Micheal D. K. Owen, David R. Shaw, Stephen C. Weller, and Robert G. Wilson. "Agricultural Weeds in Glyphosate-Resistant Cropping Systems in the United States." Weed Science 61, no. 1 (March 2013): 85–97. http://dx.doi.org/10.1614/ws-d-12-00001.1.

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A segment of the debate surrounding the commercialization of genetically engineered (GE) crops, such as glyphosate-resistant (GR) crops, focuses on the theory that implementation of these traits is an extension of the intensification of agriculture that will further erode the biodiversity of agricultural landscapes. A large field-scale study was conducted in 2006 in the United States on 156 different field sites with a minimum 3-yr history of GR corn, cotton, or soybean in the cropping system. The impact of cropping system, crop rotation, frequency of using the GR crop trait, and several categorical variables on emerged weed density and diversity was analyzed. Species richness, evenness, Shannon's H′, proportion of forbs, erect growth habit, and C3species diversity were all greater in agricultural sites that lacked crop rotation or were in a continuous GR crop system. Rotating between two GR crops (e.g., corn and soybean) or rotating to a non-GR crop resulted in less weed diversity than a continuous GR crop. The composition of the weed flora was more strongly related to location (geography) than any other parameter. The diversity of weed flora in agricultural sites with a history of GR crop production can be influenced by several factors relating to the specific method in which the GR trait is integrated (cropping system, crop rotation, GR trait rotation), the specific weed species, and the geographical location. The finding that fields with continuous GR crops demonstrated greater weed diversity is contrary to arguments opposing the use of GE crops. These results justify further research to clarify the complexities of crops grown with herbicide-resistance traits, or more broadly, GE crops, to provide a more complete characterization of their culture and local adaptation.
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Garini, Ardiya. "KADAR HEMOGLOBIN PADA PASIEN GAGAL GINJAL KRONIK YANG MENJALANI HEMODIALISIS." JPP (Jurnal Kesehatan Poltekkes Palembang) 13, no. 2 (December 23, 2019): 111–16. http://dx.doi.org/10.36086/jpp.v13i2.234.

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Latar belakang : Gagal ginjal merupakan kondisi yang mengakibatkan ginjal kehilangan kemampuannya untuk mempertahankan volume dan komposisi cairan tubuh dalam keadaan asupan makan normal. Faktor utama penyebab anemia pada gagal ginjal kronik disebabkan berkurangnya sel darah merah akibat turunnya kadar hormon eritropoetin (EPO). Salah satu terapi pada pasien gagal ginjal kronik adalah dengan hemodialisis, tetapi cara ini dapat menimbulkan komplikasi diantaranya anemia yang semakin parah. Tujuan : untuk mengetahui gambaran kadar hemoglobin pada pasien gagal ginjal kronik yang menjalani hemodialisis berdasarkan umur, jenis kelamin, lama sakit dan lama hemodialisis. Jenis penelitian yang digunakan adalah survey deskriftif dengan pendekatan cross sectional. Tempat penelitian di RSI Siti Khodijah Palembang dengan jumlah 48 sampel. Hasil : Rata-rata kadar hemoglobin = 8,065 gr/dl. Rata-rata kadar hemoglobin perempuan = 7,794 gr/dl, laki-laki = 8,213 gr/dl Rata-rata kadar hemoglobin remaja = 6,150 gr/dl, dewasa = 7,831 gr/dl, lansia 8,273 gr/dl. Rata-rata kadar hemoglobin dengan lama sakit ≤ 3 bulan = 6,750 gr/dl dan > 3 bulan = 8,122 gr/dl. Rata-rata kadar hemoglobin dengan lama hemodialisis ≤ 12 bulan = 7,600 gr/dl, > 12 bulan = 8,186 gr/dl. Kesimpulan : Kadar hemoglobin yang rendah didapat pada pasien jenis kelamin perempuan, berumur remaja, lama sakit ≤ 3 bulan dan lama hemodialisis ≤ 12 bulan.
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Li, Mao, John F. Leatherland, Matt M. Vijayan, W. Allan King, and Pavneesh Madan. "Glucocorticoid receptor activation following elevated oocyte cortisol content is associated with zygote activation, early embryo cell division, and IGF system gene responses in rainbow trout." Journal of Endocrinology 215, no. 1 (July 10, 2012): 137–49. http://dx.doi.org/10.1530/joe-12-0030.

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Increasedin ovocortisol content of rainbow trout oocytes from ∼3.5 to ∼5.0 ng.oocyte−1before fertilization enhances the growth of embryos and juveniles and changes the long-term expression pattern of IGF-related genes. This study used embryos reared from oocytes enriched with cortisol and the glucocorticoid receptor (GR) antagonist, RU486, to determine whether the growth-promoting actions of cortisol involve GR protein activation and modulation ofgrexpression. Whole-mountin situimmunohistofluorescence studies of zygotes showed that enhanced oocyte cortisol increased the immunofluorescent GR signal and activated the relocation of GR from a general distribution throughout the cytoplasm to an accumulation in the peri-nuclear cytoplasm.In ovocortisol treatment increased the number of embryonic cells within 48-h post-fertilization, and RU486 partially suppressed this cortisol stimulation of cell duplication. In addition, there was complex interplay between the expression ofgrandigfsystem-related genes spatiotemporally in the different treatment groups, suggesting a role for GR in the regulation of the expression of development. Taken together, these findings indicate an essential role for GR in the regulation of epigenomic events in very early embryos that promoted the long-term growth effects of the embryos and juvenile fish. Moreover, the pretreatment of the oocyte with RU486 had a significant suppressive effect on the maternal mRNA transcript number ofgrandigfsystem-related genes in oocytes and very early stage embryos, suggesting an action of antagonist on the stability of the maternal transcriptome.
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Nandula, Vijay K., Jeffery D. Ray, Daniela N. Ribeiro, Z. Pan, and Krishna N. Reddy. "Glyphosate Resistance in Tall Waterhemp (Amaranthus tuberculatus) from Mississippi is due to both Altered Target-Site and Nontarget-Site Mechanisms." Weed Science 61, no. 3 (September 2013): 374–83. http://dx.doi.org/10.1614/ws-d-12-00155.1.

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A tall waterhemp population from Missisippi was suspected to be resistant to glyphosate. Glyphosate dose response experiments resulted in GR50(dose required to reduce plant growth by 50%) values of 1.28 and 0.28 kg ae ha−1glyphosate for the glyphosate-resistant (GR) and -susceptible (GS) populations, respectively, indicating a five-fold resistance. The absorption pattern of14C-glyphosate between the GR and GS populations was similar up to 24 h after treatment (HAT). Thereafter, the susceptible population absorbed more glyphosate (55 and 49% of applied) compared to the resistant population (41 and 40% of applied) by 48 and 72 HAT, respectively. Treatment of a single leaf in individual plants with glyphosate at 0.84 kg ha−1, in the form of 10 1-µl droplets, provided greater control (85 vs. 29%) and shoot fresh weight reduction (73 vs. 34% of nontreated control) of the GS plants compared to the GR plants, possibly indicating a reduced movement of glyphosate in the GR plants. The amount of14C-glyphosate that translocated out of the treated leaves of GR plants (20% of absorbed at 24 HAT and 23% of absorbed at 48 HAT) was significantly lower than the GS plants (31% of absorbed at 24 HAT and 32% of absorbed at 48 HAT). A potential difference in shikimate accumulation between GR and GS populations at different concentrations of glyphosate was also studied in vitro. The IC50(glyphosate concentration required to cause shikimate accumulation at 50% of peak levels measured) values for the GR and GS populations were 480 and 140 µM of glyphosate, respectively, resulting in more shikimate accumulation in the GS than the GR population. Sequence analysis of 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), the target site of glyphosate, from GR and GS plants identified a consistent single nucleotide polymorphism (T/C, thymine/cytosine) between GR/GS plants, resulting in a proline to serine amino acid substitution at position 106 in the GR population. The GR and GS plants contained equal genomic copy number ofEPSPS, which was positively correlated withEPSPSgene expression. Thus, glyphosate resistance in the tall waterhemp population from Mississippi is due to both altered target site and nontarget site mechanisms. This is the first report of an alteredEPSPS-based resistance in a dicot weed species that has evolved resistance to glyphosate.
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Kheradpour, P., A. Stark, S. Roy, and M. Kellis. "Reliable prediction of regulator targets using 12 Drosophila genomes." Genome Research 17, no. 12 (December 1, 2007): 1919–31. http://dx.doi.org/10.1101/gr.7090407.

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Chandi, Aman, David L. Jordan, Alan C. York, Susana R. Milla-Lewis, James D. Burton, A. Stanley Culpepper, and Jared R. Whitaker. "Interference and Control of Glyphosate-Resistant and -Susceptible Palmer Amaranth (Amaranthus palmeri) Populations under Greenhouse Conditions." Weed Science 61, no. 2 (June 2013): 259–66. http://dx.doi.org/10.1614/ws-d-12-00063.1.

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Interference for 40 d after emergence (DAE) of corn, cotton, peanut, and snap bean by four glyphosate-resistant (GR) and four glyphosate-susceptible (GS) Palmer amaranth populations from Georgia and North Carolina was compared in the greenhouse. Greater interference from Palmer amaranth, measured as crop height and fresh weight reduction, was noted in cotton and peanut compared with corn or snap bean. Crop height 15 to 40 DAE was reduced similarly by GR and GS populations. Crop fresh weight, however, was reduced 25 and 19% in the presence of GS and GR populations, respectively. Measured as percent reduction in fresh weight, GR and GS populations of Palmer amaranth were controlled similarly by glufosinate, lactofen, paraquat, and trifloxysulfuron applied POST. Atrazine and dicamba controlled GR populations more effectively than GS populations.
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Books on the topic "Gr. 12"

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Polette, Nancy. Novel thinking (gr 6-12). 2nd ed. O'Fallon, Mo: Book Lures, 1987.

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Chesneau, Roger. Harrier GR 5 & GR 7: British Aerospace Harrier GR Mk5/Mk7. Ongar, Essex: Linewrights Ltd., 1990.

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David, Cox. Success in book-keeping and accounts. London: John Murray, 1987.

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David, Cox. Success in book-keeping and accounts. London: Murray, 1985.

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David, Cox. Success in book-keeping and accounts. London: John Murray, 1991.

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Jurḥ wa-milḥ. al-Dawḥah: al-Majlis al-Waṭanī lil-Thaqāfah wa-al-Funūn wa-al-Turāth, Idārat al-Thaqāfah wa-al-Funūn, Qism al-Dirāsāt wa-al-Buḥūth, 2002.

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El amigo oculto y los espíritus de la tarde. Barcelona: Editorial Noguer, 1985.

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Marta, Serrano, and Muñoz Tenllado Antonio ill, eds. The repiratory system, the breath of life. New York: Chelsea House Publishers, 1995.

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Teer, Crumpler Kathy, and Prothrow-Stith Deborah 1954-, eds. Prentice Hall health: Skills for wellness. Needham, Mass: Prentice Hall, 1994.

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1952-, Allegrante John P., Prothrow-Stith Deborah 1954-, and Pearson/Prentice Hall, eds. Prentice Hall health. Boston, Mass: Pearson/Prentice Hall, 2007.

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Book chapters on the topic "Gr. 12"

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"The Fortunes of War: An Eleventh-Century Greek Liturgical Manuscript (Sinai gr 512) and Its History." In Crusades, 185–96. Routledge, 2016. http://dx.doi.org/10.4324/9781315271583-12.

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"C. DIE SOSIADESSAMMLUNG BEI STOB., ZWEI INSCHRIFTLICHE QUELLEN UND DER CODEX RHEDIGERANUS GR. 12." In Die Sprüche der sieben Weisen, 5–11. B. G. Teubner, 1994. http://dx.doi.org/10.1515/9783110959321.5.

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"12 Der Scor. Υ.III.22 und seine Deszendenz: der Vat. gr. 313 und seine Abschriften." In Nikephoros Blemmydes, ›Epitome physica‹, 86–89. De Gruyter, 2021. http://dx.doi.org/10.1515/9783110731576-012.

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Sharma, Ravinder, Rupinder Singh, Ajay Batish, and Nishant Ranjan. "Investigations on Chemical Assisted Mechanically Blended 3D Printed Functional Prototypes of PVDF-BaTiO3-Gr Composite." In Reference Module in Materials Science and Materials Engineering. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-12-820352-1.00144-9.

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Sharma, Ravinder, Rupinder Singh, Ajay Batish, and Nishant Ranjan. "On Dynamic Mechanical Analysis of Mechanically Blended 3D Printed Functional Prototypes of PVDF-BaTiO3-Gr Composite." In Reference Module in Materials Science and Materials Engineering. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-12-820352-1.00145-0.

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"1 Diplomatische Transkription des Textes der Sprüche der sieben Weisen aus dem Codex Vrat. Rhed. Gr. 12 ff . 138r 1. 7- 138v 1. 11." In Die Sprüche der sieben Weisen, 447–48. B. G. Teubner, 1994. http://dx.doi.org/10.1515/9783110959321.447.

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Conference papers on the topic "Gr. 12"

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Cohn, Marvin J., Michael T. Cronin, and Fatma Faham. "Fitness-for-Service Evaluation of a Gr 91 to Gr 22 Dissimilar Metal Weldment Subject to Creep." In ASME 2018 Symposium on Elevated Temperature Application of Materials for Fossil, Nuclear, and Petrochemical Industries. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/etam2018-6721.

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A fitness-for-service (FFS) evaluation was performed on a cogeneration power plant high pressure steam line. The piping system included a Gr 91 to Gr 22 dissimilar metal weld (DMW) between an SA-335 Gr P91 pipe and an SA-335 Gr P22 reducer. This unit had accumulated more than 100,000 service hours. The FFS project included as-built and as-found piping stress analyses, redistribution of creep stresses, weld residual stress estimates, review of the nondestructive examination (NDE) results, evaluation of the plant information data, and a fracture mechanics evaluation. Due to tapering of the Gr P22 pipe to match the wall thickness of the Gr P91 pipe at the DMW interface, the Gr P22 pipe wall thickness was not in compliance with the ASME B31.1-2000 Code minimum wall thickness (MWT). In addition, an inspection of the single groove girth DMW revealed ultrasonic indications along the fusion face of the weld. The lack of side wall fusion (LSWF) can be considered as a planar and crack-like indication, so a fracture mechanics evaluation was performed. The piping stress analysis revealed that the DMW was subject to low axial stresses. A creep life fraction evaluation was performed for the material that does not have the LSWF indication, considering conservative creep rupture data, weld performance degradation, redistributed creep stresses, and multiaxial stresses in the DMW. Due to the low stresses, the life fraction analysis estimated more than 50 years of remaining creep life. Failure Assessment Diagrams (FADs) were developed to evaluate the component integrity for various combinations of crack depths and lengths. The reported indications should not compromise the integrity of the component subject to the typical plant operation during the next 12 years and the component is fit for continued operation. The crack propagation evaluation determined that the DMW has a predicted minimum safe operating life of at least 12 years if operated as in the past. Because the wall thickness of the tapered reducer is below the ASME B31.1 Code allowable MWT, it was recommended that the DMW be examined during a scheduled outage within 5 years and the component be replaced with Gr P91 material during a major outage within 8 years.
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Yanuarta, Daniar Eki, Mochamat Bintoro, and Nantil Bambang Eko Sulistyono. "Efektifitas Beberapa Paket Pupuk dan Umur Panen Buah Terhadap Produksi dan Mutu Benih Melon (Cucumis melo L.)." In Seminar, Expo dan Diskusi (SEEDs) Perbenihan Nasional 2017. Jember: AGROPROSS, National Conference Proceedings of Agriculture, 2017. http://dx.doi.org/10.25047/agropross.2017.26.

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Pada tahun 2013 produksi melon nasional mengalami penurunan hasil. Salah satu upaya untuk meningkatkan produksi benih melon adalah dengan memperhatikan kultur teknisnya. Penelitian ini dilaksanakan pada bulan Agustus sampai November 2016 di Desa Suco, Kecamatan Mumbulsari dan laboratorium PT Benih Citra Asia, Jl. Akmaludin 26, Kecamatan Ajung, Kabupaten Jember dengan menggunakan Rancangan Acak Kelompok (RAK) faktorial. Faktor pertama adalah Paket Pupuk Pertama (Organik 1000 gr, ZA 15 gr, SP-36 30 gr, KCL 15 gr, NPK 20 gr) per tanaman dan Paket Pupuk Kedua (Organik 1000 gr, ZA 40 gr, SP-36 60 gr, KCL 38 gr, NPK 12 gr) per tanaman. Faktor kedua adalah Umur panen (30,35,40) hari setelah polinasi. Hasil yang didapat menunjukkan bahwa paket pupuk kedua memberikan pengaruh sangat nyata (**)Â terhadap pertambahan tinggi tanaman umur 14-28 HST, yaitu 89,80 cm, umur 28-42 HST, yaitu 174,31 cm dan jumlah buah dengan rerata tertinggi, yaitu 3,56 kg. Faktor kedua menunjukkan bahwa perlakuan umur panen 30 hari setelah polinasi memberikan pengaruh berbeda sangat nyata (**) terhadap jumlah benih bernas dengan rerata tertinggi, yaitu 876,52 gr dan berat benih bernas dengan rerata tertinggi, yaitu 13,11 gr. Interaksi antara perlakuan paket pupuk dan umur panen tidak memberikan pengaruh terhadap semua semua parameter.
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Han, HS, S. Wilks, E. Paplomata, MR Modiano, C. Becerra, FS Braiteh, AI Spira, et al. "Abstract P6-12-15: Efficacy results of a phase 1/2 study of glucocorticoid receptor (GR) antagonist mifepristone (MIFE) in combination with eribulin in GR-positive triple-negative breast cancer (TNBC)." In Abstracts: 2016 San Antonio Breast Cancer Symposium; December 6-10, 2016; San Antonio, Texas. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.sabcs16-p6-12-15.

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Wilks, S., M. Modiano, A. Spira, C. Becerra, J. Walling, D. Nguyen, G. Baker, SD Conzen, and R. Nanda. "Abstract P6-13-21: Phase 1 study of GR antagonist mifepristone (M) in combination with eribulin (E) in advanced solid tumors, with dose expansion in patients (pts) with GR-positive triple-negative breast cancer (TNBC)." In Abstracts: Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 8-12, 2015; San Antonio, TX. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.sabcs15-p6-13-21.

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Wong, Lana L., John C. Estill, David V. Fix, and Rau´l B. Rebak. "Corrosion Characteristics of Titanium Alloys in Multi-Ionic Environments." In ASME 2003 Pressure Vessels and Piping Conference. ASMEDC, 2003. http://dx.doi.org/10.1115/pvp2003-2141.

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Yucca Mountain (Nevada) is designated as a high-level nuclear waste repository. The nuclear waste will be isolated by a series of engineered barriers. The metallic engineered barriers will consist of a double-wall container with a detached drip shield. The material for the external wall of the container is Alloy 22, a corrosion-resistant Ni-Cr-Mo alloy. Titanium grade 7 has been proposed for the drip shield. Ti alloys are highly resistant to all forms of corrosion due to the formation of a stable, protective and strongly adherent oxide film. The aim of this research was to characterize the general and localized corrosion behavior of Ti Gr 7, 16 and 12 in simulated concentrated ground waters. Welded and non-welded coupons were exposed for up to 5 years to the vapor and liquid phases of acidic and alkaline multi-ionic solutions at 60°C and 90°C. This paper describes the results obtained after approximately 2-1/2- to 5-1/2-year exposure to the testing electrolyte solutions. In general, the highest corrosion rate was obtained for Ti Gr 12; however, in all of the tested conditions, the corrosion rate was generally lower than 100 nm/yr. For all alloys, the highest corrosion rate was obtained in the concentrated alkaline solution.
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Mattson, C. J., and W. D. Estry. "EFFECTS OF 12-O-TETRADECANOYL PH0RB0L-13-ACETATE (TPA) ON PLATELET ADHESION-INDUCED SHAPE CHANGE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643552.

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Adherent platelets undergo changes in shape which involve conversion of the resting discoid platelet to a sphered or dentritic/pseudopodial form followed by cytoplasmic spreading to produce a fully spread cell with centralized organelles. Platelets from donors who have taken 10 gr aspirin (ASA) 4 hr prior to venipuncture show adequate pseudopod formation but defective spreading. Addition of 0.5 uM ADP is sufficient to reconstitute normal spreading suggesting that shape change is a two step process and that formation of spread platelets may require release of dense granule ADP. Since activation of platelets in suspension by ADP is associated with degradation of phosphoinositides and phosphorylation of a 40 KD protein, the potential role of this pathway in the formation of spread platelets was examined. Citrated platelets formed large aggregates when stimulated by TPA interfering with evaluation of adhesion and contact-activated shape change. When EGTA treated platelets were stimulated with TPA, aggregation was blocked but adhesion and spreading were unaffected by calcium chelation in the presence of magnesium. Therefore ASA-inhibited, EGTA-treated platelets were stimulated with 100 ng/ml TPA to activate protein kinase C, and platelet morphology was evaluated by whole mount transmission electron microscopy. TPA stimulated platelets underwent normal shape change to the fully spread stage despite endoperoxide inhibition by ASA. This data supports a role for ADP-trigqered phosphoinositide degradation in the spreading phase of adhesion induced shape change.
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Saha, P., A. Turk, K. Lurain, G. Baker, S. Conzen, and R. Nanda. "Abstract P3-07-24: The role of glucocorticoid receptor (GR) expression in predicting pathological complete response (pCR) to neoadjuvant chemotherapy in triple-negative breast cancer (TNBC)." In Abstracts: Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 8-12, 2015; San Antonio, TX. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.sabcs15-p3-07-24.

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Lutfiasari, Dessy, and Galuh Pradian Yanuaringsih. "The Effect of Soybean-Palm Date Milk Consumption on Hemoglobin Level among Adolescent." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.61.

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Background: Anemia is a problem that affects reproductive health among adolescent. High incidence of anemia among adolescents still needs an attention. One of which is the consumption of foods containing iron (Fe). The purpose of this study was to examine the effect of soybean-date palm (kurma) milk consumption on hemoglobin (Hb) levels among adolescent girls. Subjects and Method: A quasi experiment was conducted at the Al Ma’ruf Islamic Boarding School in Kediri, East Java, from March to July 2020. The samples obtained were 28 people who had Hb below 12 g% and were not menstruating. The sample was divided into 4 treatment groups i.e. A group (100 g soybean and 100 g date palm), B group (100 g soybean and 50 gr date palm), C group (100 g soybean and 60 g date palm), D group (50 g soybean and 60 gr date palm). The dependent variable was hemoglobin level. The independent variable was the consumption of soy- date palm milk. Data of hemoglobin levels were taken before and after the consumption of soybean- date palm milk with a ratio data scale. The other data were collected using observational sheet. The data were analyzed using t-test. Results: Hemoglobin levels was increased from 10.24 to 12.03 (p= 0.021) in A group, and it was statistically significant. While groups B, C, and D had no effect on the consumption of soybean-date palm milk on hemoglobin levels among adolescent girls. Conclusion: Soybean-date palm milk consumption with ratio of 1:1 increasing hemoglobin level among adolescent girls. Keywords: hemoglobin levels, soybean, date palm, adolescent girl Correspondence: Dessy Lutfiasari. Kadiri University, East Java, Indonesia. Email: dessylutfiasari@unik-kediri.ac.id. Mobile: +62 813-3622-9675 DOI: https://doi.org/10.26911/the7thicph.05.61
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Hadinata, Dwie, Yuliawan Mulia, Theodore Rudyanto, Adi Laharan, Poultje Haurissa, Hedriawan Soemantri, Borman Subroto, Rangga Suradilaga, and Rudi Sugianto. "A Success of Modified Water Based Mud as Drilling Fluid Optimization to Drill Shale Formation at South-S Wells." In International Petroleum Technology Conference. IPTC, 2021. http://dx.doi.org/10.2523/iptc-21379-ms.

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Abstract This paper is to explain the optimization of using Modified Shale Inhibitor Water Based Mud (WBM) to drill up to 5,500 ft interval of K-formation reactive shale on South-S Gas Wells. By combining a comprehensive method consists of drilling fluid laboratory test and lessons learned in S area, the optimization was done by determining the amount or concentration of Polyamine & KCl combination, pure Polyamine, Polyamine & NaCl combination, and Pure KCl-Polymer in WBM system as a shale inhibitor. The comparison of shale inhibitor compositions were made by comparing the achieved optimization of drilling fluid program such as drilling time, cost economic, and environment aspect. The basic idea of the WBM optimization was to improve drilling time during drill 5,000 ft footage in 12-1/4" hole section in reactive shale formation as per drilling program. Laboratory test consists of Linear swelling meter with various parameter concentration of Polyamine & KCl combination, pure Polyamine, Polyamine & NACl combination, and Pure KCl-Polymer in WBM system as a shale inhibitor and cation exchange capacity test (CEC or MBT) was done using composite of offset well shale cutting. Experience showed that on 12-1/4" hole section, while facing reactive shale (CEC 18 - 24 meq/100 gr) from K-formation on South-S, modified WBM was proven to eliminate reactive shale issues and lead to budget saving without environmental issues.
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Martinez-Vega, Pamela, Araceli Lopez-Badillo, J. Luis Luviano-Ortiz, Abel Hernandez-Guerrero, and Jaime G. Cervantes. "Low Cost Cooling Device for High Power LED Lamps." In ASME 2020 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/imece2020-24630.

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Abstract The modern world progressively demands more energy; according to forecasts energy consumption will grow at an average annual rate of 3 percent. Therefore, it is necessary to purchase products or devices that are efficient and environmentally friendly. Technology in LED (Light Emitting Diode) lighting is presented as an alternative to energy saving, since LEDs have proven to be extremely efficient, have a long service life and their cost-effective ratio is very good. However, the heat emitted by the LED chip must be dissipated effectively, since the overheating of the chip reduces the efficiency and lifetime of the lamp. Therefore, heat sinks that are reliable, efficient and inexpensive should be designed and built. The present work proposes new designs for heat sinks in LED lamps, some of the models in the design of the fins refer to the Fibonacci series. The models proposed in the present work that have a significant advantage are the Type 1E Model (5.2% mass savings and better thermal efficiency of 8.33%), GR Type 1 Model (3.12% lighter and 3.33% more efficient) and the GRL Type Model (4. 51% mass savings and 5.55% thermally more efficient) compared to the Type 2 Reference Model proposed by Jang et al. [12].
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