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Dissertations / Theses on the topic 'Graft from'
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1
Kee, R. Andrew. "Synthesis and characterization of arborescent graft copolymers." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ60542.pdf.
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Khadir, Abderrahim. "Applications and novel syntheses of arborescent graft copolymers." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0004/NQ44768.pdf.
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Koh, Mickey Boon Chai. "Alloantigen specific T cell depletion from stem cell grafts for the prevention of graft versus host disease." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392696.
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Isarov, Sergey A. "Protein-Polymer Conjugates via Graft-From Ring-Opening Metathesis Polymerization." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1427750335.
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Sendorek, Jerzy George. "Rheological properties of long-chain branched chlorinated poly(isobutylene-co-isoprene)-graft-polybutadiene terpolymers (CIIR-g-BR)." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0008/NQ30643.pdf.
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Goudie, Beth Ann. "The transition from hospital to home following coronary artery bypass graft surgery." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq22742.pdf.
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Wang, Tiffany. "Local delivery of FTY720 from tissue derived matrices for bone graft integration." Thesis, Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/52944.
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Despite advances in bone grafting technology for musculoskeletal injury, re-injury or incomplete healing persists. Efforts to modify bone allografts sing proteins and growth factors show improvement in wound healing outcomes. We use FTY720, an agonist of S1P receptors 1 and 3, to improve bone graft integration through bone regeneration and vascularization. Four methods of delivering FTY720 into a bone defect are described: 1) FTY720 loaded onto a PLAGA-coated bone allograft and implanted in a critical size rat cranial defect; 2) FTY720 loaded onto a PLAGA-coated bone allograft and implanted in a rat tibial defect; 3) FTY720 loaded into a Matrigel plug and injected into a mouse tibial fracture; and 4) FTY720 directly adsorbed to human bone xenografts and implanted in a critical size rat cranial defect. In each of these models, FTY720 release was characterized, and bone regeneration and vascularization was monitored within the defect. Additionally, local tissue composition and immune response was evaluated. The results presented here indicate that FTY720 released locally into the bone defect improved new bone formation and vascularization, promoting improved graft integration.
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Herns, Mary V. "Psychological and social aspects of recovery from coronary artery vein graft surgery." Thesis, University of Surrey, 1988. http://epubs.surrey.ac.uk/844315/.
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The present study sought to improve on previous studies of open-heart surgery patients by taking a broad view of outcome/recovery. A group of male coronary artery vein graft ('CAVG') patients were followed through from time of referral to six months post-surgery and changes in physical, psychological and social functioning were monitored. The relationships between the different areas of functioning were also examined. Two aspects of psychological function, namely intellectual performance and mood, and three aspects of social function, namely social/leisure, family and work activities, were assessed. Additionally, the beliefs and experiences of the subjects and their spouses relating to the development of heart disease and to recovery from surgery were explored. A single-case research design was used in order to examine and, where possible, explain individual differences in terms of specific patterns of functioning before and after surgery. For the group as a whole, pre- to post-surgery improvements were found in physical functioning and in mood, whereas social/leisure, family and work functioning were apparently unaffected. Post-operative intellectual performance, as measured with a battery of standardised neuropsychological tests, was unimpaired in most cases. There was scare variation in outcome, however, and close examination of the individual cases revealed the importance of such factors as family relationships, social 'buffers', denial and 'hopelessness' in determining the reaction of the individual to the surgery. The findings of the present study were considered to have implications for both further research and for pre- and post-operative interventions with this patient group.
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Maclaine, Sarah Elizabeth. "The production of living, tissue engineered, bone graft from progenitor cells using nanotechnology." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4558/.
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The principal aim of this research was the development of a technique (based upon the effects of nanoscale topography) that facilitates the in vitro expansion of bone graft for subsequent implantation. Nanoscale topography increases the bioactivity of a material and stimulates specific responses at the molecular level (third generation biomaterial properties). Nanoscale topography thus confers these third generation properties upon biomaterials that are otherwise first generation (bioinert) or second generation (bioresorbable or bioactive) in nature. Two topographies (nanopits and nanoislands) were embossed into the clinically licensed bioresorbable polymer Polycaprolactone (PCL). A protocol was developed which enabled three dimensional cell culture using double-sided embossing of substrates, seeding of both sides, and vertical positioning of the substrates during cell culture. Human bone marrow was harvested and the mononuclear cell fraction culture expanded. These human bone marrow cells (HBMCs) were used for cellular analysis of substrate bioactivity. In addition, acellular analysis of substrate patterning and degradation was also performed. The osteogenic behaviour (and cell line specificity) was demonstrated using alizarin red staining, immunohistochemistry, real-time polymerase chain reaction (rtPCR), and quantitative PCR (qPCR). The osteogenicity of PCL was increased by the presence of nanotopography, and by the incorporation of hydroxyapatite (HA) into the PCL forming a hydroxyapatite-PCL composite (HAPCL). The performance of these substrates was compared to exposure to bone morphogenic protein 2 (BMP2), and the use of osteogenic media. The protocol from shim production to bone marrow harvesting and vertical cell culture on nanoembossed PCL has been shown to be reproducible and potentially applicable to economical larger scale production.
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Kent, Niall William. "Development of a novel in-vivo setting bone graft substitute from bioactive glass." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8442.
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Calcium phosphate cements are in-vivo setting, injectable calcium phosphate based biomaterials. They are made of calcium phosphate salts which when mixed with water react to form apatite, the mineral phase of bones and teeth. This study investigates a novel way of forming calcium phosphate cements using bioactive glasses. The aim of the work was to discover a novel route of synthesis using a silicate bioactive glass. Fifteen glass compositions were produced designed to investigate P2O5 content, CaF2 content and calcium to sodium ratio within the glass. Glasses were produced via a melt-quench route before being milled and sieved to below 38 μm. The bioactive glass and Ca(H2PO4)2 powders were mixed in an overall calcium to phosphate ratio of 1.67. The cement powder was then reacted with a 2.5 % solution of Na2HPO4. The paste was then mixed and then placed into cylindrical moulds. Eight samples were immersed into Tris buffer solution for 1 hour, 1 day, 7 days or 28 days. The compressive strength was measured for each specimen as well as SEM performed and the setting times for each composition was studied using the Gilmore needle test. The cement phase was analysed using 31P & 19F MAS-NMR, FTIR and XRD. The results showed that both compressive strength and setting time was dependent upon glass composition. As sodium content was increased both the initial and final setting times decreased. Increased fluoride addition caused a decrease in the setting time. In the fluoride free compositions octacalcium phosphate was identified in all compositions. The cement setting reaction for these compositions followed a similar reaction of first forming dicalcium phosphate dihydrate which transformed to octacalcium phosphate then eventually hydrolysing to hydroxyapatite. When fluoride was incorporated into the cement the phases formed were fluoridated-apatite and DCPD. In conclusion a novel method of producing calcium phosphate cements was discovered using a bioactive glass as a reactive precursor. It was shown that the cement phase, setting time and compressive strength could all be altered by changing the glass composition.
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Kageyama, Shoichi. "Graft Reconditioning With Nitric Oxide Gas in Rat Liver Transplantation From Cardiac Death Donors." Kyoto University, 2014. http://hdl.handle.net/2433/193570.
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Xiao, Shengdong. "Transient Crosslinks from Oligo(ß-alanine) Segments Grafted to Butyl Rubber." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1493733109328128.
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Piaoran, Ye. "Synthesis of Polymers and Polymer Brushes through RAFT Polymerization via Flow Chemistry." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1491229581133419.
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Cai, Liang. "GRAFT COPOLYMER AEROGELS FROM SULFONATED SYNDIOTACTIC POLYSTYRENE FUNCTIONALIZED WITH A QUATERNARY PHOSPHONIUM-CONTAINING RAFT AGENT." University of Akron / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1468851884.
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Seifried, Andrea Ursula. "FoxP3 positive T cells in graft biopsies from living donor kidney transplantants after donor-specific transfusions /." [S.l.] : [s.n.], 2009. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
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Liu, Yu. "Immunosuppressant-free allotrasplantation of the trachea : The antigenicity of tracheal grafts can be reduced by removing the epithelium and mixed glands from the graft by detergent treatment." Kyoto University, 2000. http://hdl.handle.net/2433/151405.
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Morishima, Manabu. "Sustained release of vancomycin from a new biodegradable glue to prevent methicillin-resistant Staphylococcus aureus graft infection." Kyoto University, 2013. http://hdl.handle.net/2433/180460.
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Manabu Morishima, Akira Marui, Shigeki Yanagi, Takamasa Nomura, Naoki Nakajima, Suong-Hyu Hyon, Tadashi Ikeda, and Ryuzo Sakata. Sustained release of vancomycin from a new biodegradable glue to prevent methicillin-resistant Staphylococcus aureus graft infection. Interact CardioVasc Thorac Surg (2010) 11(1): 52-55 doi:10.1510/icvts.2010.232447<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第17856号<br>医博第3825号<br>新制||医||1000(附属図書館)<br>30676<br>京都大学大学院医学研究科医学専攻<br>(主査)教授 一山 智, 教授 伊達 洋至, 教授 鈴木 茂彦<br>学位規則第4条第1項該当
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Nguyen, Duc Anh. "Cycloalkenyl macromonomers from new multifunctional inimers : a platform for graft, bottle-brush and mikto-arm star copolymers." Thesis, Le Mans, 2016. http://www.theses.fr/2016LEMA1001/document.
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Le sujet de cette thèse concerne l'élaboration de macromonomères, de copolymères greffés et de polymères étoiles de type 'mikto-arm'. De telles architectures macromoléculaires ont été synthétisées par la combinaison de techniques de polymérisation contrôlées/vivantes telles que la polymérisation par ouverture de cycle (par métathèse) (RO(M)P) etde chimie 'click' orthogonales : cycloaddition 1,3-dipolaireazoturealcyne catalysée au cuivre (CuAAC) et thiol-ène.Dans un premier temps, des macromonomères originaux à fonctionnalité polymérisable (oxa)norbornène portant deux chaînes macromoléculaires poly(e-caprolactone) (PCL) et/ou poly(oxyde d'éthylène) (POE) ont été synthétisés par combinaison ROP/CuAAC. Les macromonomères à fonctionnalité (oxa)norbornène avec deux chaînes PCL de masse molaire moyenne en nombre (Mn) compris entre 1400 et 5000 g/mol ont été obtenus par ROP organocatalysée. La synthèse des macromonomères POE44-b-PCLn à fonctionnalité norbornène avec un bloc PCL de longueur variable (1100 g/mol <br>The objective of the present thesis was the preparation of complex macromolecules by the combination of controlled/livingpolymerization methods such as ring-opening (metathesis) polymerization (RO(M)P) and highly efficient orthogonal chemistries: copper-catalyzed azide-alkyne coupling (CuAAC) and thiol-ene reactions.In the first part of this work, a series of well-defined structural (co)polymers containing a cycloolefin (norbornene (NB) oroxanorbornene (ONB)) functionality bearing two polymer chains including poly(ε-caprolactone) (PCL) and/or poly(ethylene oxide) (PEO) have been successfully prepared using the combination of ring-opening polymerization (ROP) and CuAAC ‘click’ chemistry. Well-defined (oxa)norbornenyl-functionalized bis-PCL polymers with PCL chain ranging from 1400 to 5000 g/mol were obtained by organocatalyst-mediated ROP. Norbornenyl-functionalized PEO-b-PCL block copolymers with PCL block in the range 1100 to 4100 g/mol were synthesized from commercially available PEO 2000 g/mol by CuAAC followed by ROP of CL. The presence of a hydrophilic PEO chain and a hydrophobic PCL chain in norbornenylfunctionalizedPEO-b-PCL copolymers gives rise to self-assembling properties in water solution. Critical micellar concentrations (CMC)are in the range of 0.08 – 0.006 g/L for copolymers with PCL chain length ranging from 10 to 36 CL units, respectively. Thecorresponding micelles show hydrodynamic diameters in range of 10 – 23 nm with low polydispersities.In the second part of this work, well-defined copolymers were used to prepare bottle-brush and (mikto-arm) star copolymersthrough reactions involving the cycloolefin functionality. On the one hand, high density grafting bottle-brush copolymerspoly(oxa)norbornene-g-bisPCL, polynorbornene-g-PEO/PCL (PNB-g-(PEO/PCL)) and PNB-b-(PNB-g-(PEO/PCL)) were achieved by ROMP according to the ‘grafting through’ strategy using Grubbs’ catalysts. On the other hand, PCL, PEO, PNIPAM-based 3-arms star, 4-arms star copolymers were obtained via radical thiol-ene reactions as demonstrated by 1H NMR, SEC and MALDI-ToF MS analysis.The high reactivity of these copolymers toward ROMP and thiol-ene reactions makes them interesting candidates in order toprepare new well-defined copolymers with controlled structures and properties through highly efficient synthetic strategies
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Tinajero, Díaz Ernesto. "Hybrid block and graft copolymers made from macrolactones and α-amino acids for applications as drug delivery nanosystems". Doctoral thesis, Universitat Politècnica de Catalunya, 2019. http://hdl.handle.net/10803/667299.
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Naturally produced peptides or proteins can be regarded as highly refined polymers. When synthetic polymers are married to proteins or peptides, the resulting bioconjugates can synergistically combine the properties of the individual components and overcome their separate limitations. This Thesis is focused on the study of hybrid copolymers based on polypeptides and polymacrolactones. Block and graft copolymers have been synthesized by making use of the ring opening polymerization method (ROP) mainly and extensively characterized including both their chemical structure and their structure in the solid state. The self-assembly properties of the new copolymers have been preliminary examined regarding their potential application as nanocarriers for pharmaceutical compounds.
This Thesis initially reports the ROP of w-pentadecalactone (PDL) using different amino-ended initiators and assisted by either organic or enzymatic catalysts. This method was then extended for the ROP of PDL using bisamino-ended poly(ethylene glycol) (PEG) for the preparation of poly(w-pentadecalactone)-b-poly(ethylene glycol)-b-poly(wpentadecalactone) [PPDLx-PEG-PPDLx] triblock copolymers. These amphiphilic ABA-type copolymers were able to selfassemble in water to form nanoparticles with diameters between 100 and 200 nm.
Hybrid copolymers of poly(ester-peptide) or poly(ether-ester-peptide) type exhibiting different architectures (e.g. diblock, triblock, graft or triblock/grafted) respectively, were then synthesized using as building blocks: poly(w-pentadecalactone), poly(globalide) (PGl), PEG as well as polypeptides derived from the L-glutamic acid (Glu), L-lysine (Lys), L-alanine (Ala) and L-phenylalanine (Phe) a-amino acids. The hybrid copolymers were synthesized through several stages depending on the desired architecture. The first stage in the preparation of these copolymers was the synthesis of macroinitiators from PDL or PGl containing either an amino group at the end of the chain or multiple amine groups along their polymeric chain. In the second stage, such macroinitiators were used to trigger the polymerization of the a-amino acid N-carboxyanhyrides (NCA) with the COOH group of L-glutamic acid and NH2 of L-lysine duly protected as g-benzyl-L-glutamate (BLG) and eNcarbobenzoxy-L-lysine (ZLL) respectively. Some copolymers containing BLG or ZLL units were treated with acids to render copolymers bearing the amino acids residues with their COOH or NH2 functionalities in the free form.
All of the synthesized copolymers were fully characterized through GPC and NMR spectroscopy. The thermal properties were studied by TGA and DSC techniques. The conformation adopted by the peptide-based copolymers in the solid-state was assessed by FTIR, and their crystalline structure was examined by X-ray diffraction using synchrotron radiation in most cases. The conformation in aqueous solution of water-soluble copolymers containing Glu or Lys residues in the free form was explored by circular dichroism.
The self-assembly behavior in aqueous medium of all the amphiphilic copolymers was investigated with the purpose of obtaining nanoparticles with the appropriated diameters required for their application as biomedical nanocarriers. The nanoparticles were duly characterized by light scattering and SEM and TEM microscopies. Block and graft copolymers were able to load doxorubicin and release it under pH control. Copolymers containing L-lysine were shown to be able of condensing DNA. The potential of these copolymers as DDS of anticancer drugs and vectors for transfection have been evidenced.<br>Los polipéptidos o proteínas obtenidos de manera natural son considerados como polímeros altamente refinados. Cuando los polímeros sintéticos se unen a proteínas o polipéptidos, los sistemas bioconjugados que se obtienen pueden sinérgicamente combinar las propiedades de sus componentes individuales y mejorar las propias limitaciones que tienen por separado. La proteína o el elemento polipeptídico puede impartir propiedades bifuncionales al bioconjugado, mientras que el polímero sintético puede mejorar la estabilidad proteica, la solubilidad y la biocompatibilidad. Esta tesis está enfocada en el estudio de copolímeros híbridos basados en polipeptidos y polimacrolactonas. Copolímeros tipo bloque e injerto fueron sintetizados utilizando principalmente la polimerización por apertura de anillo y extensamente caracterizados tanto su estructura química, como su estructura en estado sólido. Las propiedades de auto-agregación de los nuevos copolímeros han sido anteriomente examinadas respecto a su potencial aplicación como nanotransportadores de compuestos farmacéuticos. Esta Tesis inicialmente reporta la homopolimerización de w-pentadecalactona (PDL) usando diferentes iniciadores aminoterminados mediante el uso de catalizadores tanto orgánicos como enzimáticos. Este se extiende a la ROP de PDL usando poli(etilén glicol) bisamino-terminado (PEG) para la preparar copolímeros tribloque poli(w-pentadecalactona)-b-poli(etilén glicol)-b-poli(w-pentadecalactona) [PPDLx-PEG-PPDLx]. Estos copolímeros de tipo ABA fueron capaces de auto-agregarse en agua para formar nanopartículas con diámetros entre 100 y 200 nm. Por otra parte, sistemas híbridos de tipo poli(éster-péptido) o poli(éter-éster-péptido) que presentan distintas arquitecturas (por ejemplo dibloque, tribloque, injerto, o tribloque-injertado) respectivamente, se sintetizaron utilizando como bloques de construcción derivados de macrolactonas (w-pentadecalactona), globalida) y a-amino ácidos (ácido L-glutámico (Glu), Llisina (Lys), L-alanina (Ala) y L-fenilalanina (Phe) así como poli(etien glicol) telequélico. Los copolímeros híbridos fueron sintetizados en varias etapas dependiendo de cuál fuese la arquitectura deseada. La primera etapa fue la preparación de los macroiniciadores a partir de PDL o PGl conteniendo en su estructura ya sea un grupo amino en el extremo de la cadena, o múltiples grupos aminos a lo largo de la cadena polimérica. En la segunda etapa, los macroiniciadores fueron utilizados en la polimerización de a-amino ácidos N-carboxianhídridos (NCA), con los grupos COOH del ácido L-glutámico y el grupo NH2 de la L-lisina apropiadamente protegidos como g-bencil-L-glutamato (BLG) y eN-carbobenzoxi-L-lisina (ZLL) respectivamente. Para los copolímeros que contienen bloques peptídicos de BLG o ZLL, las funcionalidades COOH o NH2 fueron regeneradas bajo condiciones ácidas, para producir así los copolímeros conteniendo el amino ácido en su forma libre. Todos los copolímeros sintetizados fueron completamente caracterizados mediante GPC y espectroscopia de RMN. Las propiedades térmicas fueron estudiadas por las técnicas de TGA y DSC. La conformación adoptada por los copolímeros en el estado sólido fue estudiada por FTIR, y su estructura cristalina fue analizada mediante difracción de rayos X usando radiación sincrotrón en la mayoría de los casos. La conformación en solución acuosa de los copolímeros solubles en agua, que contienen residuos de Glu o Lys, fue analizada por dicroísmo circular. Se estudió el comportamiento de todos los copolímeros para auto-agregarse en agua obteniéndose partículas con diámetros del orden nanométrico, como se demostró por DLS así como también por SEM y TEM, las cuales son apropiadas para ser aplicadas en biomedicina. Las nanopartículas de copolímeros dibloque y de injerto conteniendo ácido L-glutámico fueron capaces de incorporar doxorubicina y efectuar su liberación bajo control por medio del pH. Por otro lado, los copolímeros dibloque y de injerto con bloques conteniendo L-lisina mostraron la habilidad de condensar el ADN, demostrando así su potencial uso como vectores en transfección.
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Zolten, Avram J. (Avram Jeffery). "Construct Use and Self-Aspect Change in Recovery From Coronary Artery Bypass Graft Surgery: a Personal Construct Analysis." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc278306/.
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Cognitive ratings that use bipolar constructs based upon similarity and contrast have been shown to be biased towards the similarity pole in approximately a 62/38 ratio. This bias has also been known to shift in the contrastive direction for individuals who have psychiatric problems. This quantitative measure of cognitive change has a potential for characterizing cognitive changes that occur during the disease process, including recovery from disease. The present study investigated changes in self-aspect ratings and bipolar construct use in adult male veterans who had undergone coronary artery bypass graft surgery. Results indicated that treatment
subjects' self-aspect and construct ratings were more negative than controls'. Results also indicated that all subjects rated core interpersonal self-aspects closest to the expected bias, while self-aspects related to cardiac recovery problems were rated in the most contrastive direction. The results finally suggested that the greatest degree of change for the treatment subjects were in emotionally generated constructs. The results suggested a preliminary validation for characterizing cognitive changes in the disease process by measuring shifts in bipolar construct ratings.
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Masano, Yuki. "Auxiliary xenotransplantation as an in vivo bioreactor － Development of a transplantable liver graft from a tiny partial liver." Kyoto University, 2020. http://hdl.handle.net/2433/252980.
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Lui, Sing-leung, and 雷聲亮. "The in vivo mechanism of actions of mycophenolate mofetil: insights from murine models of allograft rejection,endotoxemia, ischemia reperfusion injury and lupus nephritis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B26625374.
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Maggs, Luke. "The role of stem cell graft derived natural killer cells in regulating patient outcomes from allogeneic haematopoietic stem cell transplantation." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8633/.
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Myeloid and lymphoid malignancies are potentially curable through a graft versus leukaemia (GvL) effect following allogeneic haematopoietic stem cell transplantation. Whilst donor T cell are thought to be the main mediators of GvL, the effect of donor NK cells within HLA matched T cell depleted transplant setting is more unclear. Patient blood samples were analysed during the first month post-transplant, with higher reconstitution of NK cells at two weeks conferring a relapse protection association. Donor stem cell graft samples, from which NK cells within the patient at two weeks are thought to be derived, similarly displayed a strong association between high NK cell dose and protection from disease relapse. CD56dimDNAM+ NK cells were found to be the population with the most significant association. The ability of NK cells to kill AML blasts in a DNAM dependent manner was shown indicating that direct killing of residual tumour cells may be a valid mechanism of GvL. These findings suggest that optimising the number of NK cells within stem cell grafts should be considered as a means to prevent disease relapse.
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Kendel, Friederike [Verfasser]. "Gender Differences in Mortality and Physical Functioning After Coronary Artery Bypass Graft Surgery : An Analysis from a Psychosocial Perspective / Friederike Kendel." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2007. http://d-nb.info/1021938408/34.
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Bradshaw, Terence L. "Comprehensive Assessment of Organic Apple Production in Vermont: Experience from Two Orchard Systems, 2006-2013." ScholarWorks @ UVM, 2015. http://scholarworks.uvm.edu/graddis/327.
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Despite substantial consumer demand and willingness to pay premium prices for organically grown fruit, apple growers in Vermont and other New England states have been slow to adopt certified organic practices. Barriers cited in the past to increased adoption of organic apple production in the region include susceptibility of traditionally grown cultivars to apple scab, lack of effective insect pest management materials, and few available effective options for fruit thinning. Recent changes in apple cultivar plantings in the region, introduction of new insect pest management materials, and advances in crop thinning justified an evaluation of organic apple production systems containing cultivars identified as important to the future of the apple industry. In 2006, two apple orchards were established at the University of Vermont Horticulture Research and Education Center in South Burlington, VT to comprehensively evaluate the five commercially-important apple cultivars of `Ginger Gold', `Honeycrisp', `Liberty', `Macoun', and `Zestar!' over eight growing seasons in two organically-managed orchard production systems, including a newly-planted high-density orchard (Orchard 1) and in an existing, medium-density orchard which was top-grafted to the new cultivars (Orchard 2). Parameters for tree growth and survival, crop yield, disease and arthropod pest incidence on foliage and fruit, and long-term economic return, including a twenty-year projection of net present value (NPV) of each cultivar in the two systems were evaluated in this study.
`Ginger Gold', despite high incidence of some diseases on foliage and fruit, performed the best in both orchard systems overall. The cultivar was among the cultivars with the highest measurements of tree growth. `Ginger Gold', along with `Honeycrisp', had the highest cumulative net crop yield per tree in Orchard 1 and the highest in Orchard 2. Notably, apple scab on `Honeycrisp' foliage and fruit and `Zestar!' fruit in both orchards was at a level that was not significantly different from `Liberty', a scab-resistant cultivar on which no scab was observed. However, `Honeycrisp' had the highest incidence of fruit rots in both orchards, but it was not significantly different than `Zestar!' in Orchard 1. Management of lepidopteran pests of fruit was a major challenge on all cultivars over the years of the study. For most of the tree growth parameters and cumulative net crop yield, `Liberty' was among the lowest group of cultivars in both orchards. Cumulative net crop yield of both `Macoun' and `Zestar!' were also among the lowest in both orchards with the top-grafted `Macoun' and `Zestar!' trees having significant tree death compared to the other cultivars in Orchard 2.
Harvested fruit were graded to commercial standards and cumulative gross and net income calculated from grade distribution, crop yield, and fruit price data. In Orchard 1, `Ginger Gold' and `Liberty' had greater cumulative gross income per hectare from 2006-2013, in excess of US$40,000, compared to `Liberty'. However, after management costs were deducted, all cultivars in Orchard 1 had negative cumulative net income of $-77,892 or less. In Orchard 2, all cultivars had positive cumulative net income for 2006-2013, and `Ginger Gold' had the highest at $109,717/ha. The twenty-year projected NPV was negative for all cultivars in Orchard 1, but in Orchard 2, all cultivars had positive NPV with `Ginger Gold' having the highest among the cultivars.
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Con, Andrea Helen. "Depression and social support as predictors of functional impairment and pain in men and women recovering from coronary artery bypass graft (CABG) surgery." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq24110.pdf.
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Keeping, Lisa. "Bridging the transition from hospital-to-home: Effects of the VITAL telehealth program on recovery in coronary artery bypass graft surgery patients and their caregivers." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86505.
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This randomized controlled trial determined whether the delivery of a telehealth program after discharge from hospital for coronary artery bypass graft (CABG) surgery made a difference in the post-surgical adjustment and health service use of patients and caregivers. Patients and caregivers (n=182) consented to be randomly assigned to receive one week of daily home audio-video visits from a nurse or routine cardiac instruction only in-hospital. Participants completed individual telephone interviews the day before surgery and 5 days and 3 weeks after discharge..<br>The primary outcomes were changes in anxiety between entry into the program and 3 weeks after discharge for patients and caregivers. Exploratory outcomes included changes in participants' depression symptoms, perceived uncertainty, illness control, support, and conflict with the caregiver, as well as use of health services over the same time period. The potential moderating effects of sex and coping style were also explored..<br>Data were analyzed using 2x2 analyses of covariance assessing the main effects of telehealth and patient sex and their interaction on changes in the dependent variables, including baseline scores as covariates. Results showed no difference between changes in anxiety for patients in telehealth versus usual care. However, patients in telehealth showed greater decreases in perceived uncertainty (p=.03) and increases in perceptions of treatment control (p=.09) than the comparison group. Also, fewer telehealth patients contacted their physicians (p=.04). For caregivers of male patients in telehealth there was a greater change in anxiety than for caregivers of male patients in usual care (p=.0003). While greater decreases in uncertainty (p=.002) and increases in perceived personal control (p=.10) were also realized for caregivers of male patients, greater reductions in depression symptoms (p=.03) and perceptions of conflict (p=.04) were experienced by caregivers in telehealth compared to usual care, regardless of the sex of the caregiver. The coping styles of neither patients nor caregivers influenced their responses to telehealth. Finally, changes in caregivers of male patients' uncertainty were associated with reductions in anxiety, and accounted for more than one third of the observed changes in anxiety. These results can help guide the recruitment of patients into telehealth with knowledge that male and female CABG surgery patients and caregivers can benefit from the service, though in different ways. Future research that examines caregiver and patient outcomes needs to include enough participants of both sexes in order to achieve adequate power to detect clinically meaningful results for women and men.<br>Cet essai clinique randomisé (ECR) servait à déterminer si la prestation d'un programme de Télésanté après un congé de l'hôpital à la suite d'une intervention de pontage aortocoronarien a eu un impact positif sur l'adaptation postopératoire et l'utilisation de services de santé chez les patients et les aidants naturels. Les patients et les aidants naturels (n=182) ont consenti à être répartis de façon aléatoire en deux groupes : l'un recevant des visites audio vidéo quotidiennes à la maison et l'autre, des instructions de routine suivant une intervention cardiaque seulement à l'hôpital. Les participants ont pris part à des entrevues téléphoniques individuelles la journée précédant l'intervention, puis 5 jours et trois semaines après le congé de l'hôpital.<br>Les mesures de résultats primaires incluaient les changements au niveau de l'anxiété chez les patients et les aidants naturels entre la date d'entrée dans le programme et trois semaines après le congé de l'hôpital. Les mesures de résultats exploratoires, incluaient les changements au niveau des symptômes de dépression des participants, de l'incertitude perçue, du contrôle de la maladie, du soutien/des conflits avec l'aidant naturel et de l'utilisation des services de santé au cours de la même période. Les effets modérateurs potentiels du sexe et du style d'adaptation ont également été explorés.<br>Les données ont été examinées selon des analyses de covariance 2x2 évaluant les effets principaux du programme de Télésanté et du sexe des patients, et de leur interaction sur les changements dans les variables dépendantes, incluant les pointages de bases comme covariables. Les résultats n'ont révélé aucune différence entre les changements au niveau de l'anxiété chez les patients qui ont bénéficié du programme de Télésanté versus ceux qui ont disposé des soins habituels. Toutefois, les patients qui ont bénéficié du programme de Télésanté ont présenté des baisses plus importantes au niveau de l'incertitude perçue (p=.03) et des hausses au niveau des perceptions quant au contrôle du traitement. De plus, on a constaté que moins de patients qui ont bénéficié du programme de Télésanté ont contacté leurs médecins (p=.04). Les aidants naturels des patients de sexe masculins ont connu de plus importants changements au niveau de l'anxiété que les aidants naturels des patients de sexe masculins qui ont bénéficié de soins habituels (p=.0003). Tandis qu'il y a eu d'importantes baisses au niveau de l'incertitude (p=.002) et des hausses au niveau de la perception du contrôle personnel (p=.10) auprès des aidants naturels des patients de sexe masculins, tous les aidants naturels du programme de Télésanté ont connu de plus importantes baisses au niveau des symptômes de la dépression (p=.03) et des perceptions au niveau des conflits (p=.04) que les aidants naturels de soins de santé habituels et ce, indépendamment du sexe des patients . Ni le style d'adaptation des patients ou des aidants naturels n'ont eu d'influence sur leurs réponses au programme de Télésanté. Enfin, les changements au niveau de l'incertitude chez les aidants naturels des patients de sexe masculins ont été associés à la baisse de l'anxiété, et représentaient plus du tiers des changements observés au niveau de l'anxiété. Ces résultats pe
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Burrough, Michelle Geraldine. "Can postoperative length of stay or discharge within five days of first time isolated coronary artery bypass graft surgery be predicted from preoperative patient variables?" Thesis, City University London, 2010. http://openaccess.city.ac.uk/12135/.
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In recent years there has been a steady increase in the number of patients being discharged within five days of coronary artery bypass graft surgery. The ability to be able to predict those patients likely to be discharged within five days of surgery is important to improve the individual patient pathway, plan resources and surgical activity, and also to achieve current policy objectives. Guided by the theory of Stress, Appraisal and Coping (Lazarus and Folkman, 1984), the aim of this observational study was to develop and validate local multivariate models from preoperative patient variables for the purpose of predicting postoperative length of stay and discharge within five days of surgery. The study also investigated the influence of previously neglected psychological variables on these outcomes. The study was conducted in two phases: Phase I A cross-sectional survey design was used for univariate and multivariate analyses of thirty one empirically or theoretically derived variables. Previously collected data was retrospectively analysed for 1043 consecutive patients undergoing first time isolated coronary artery bypass graft surgery at a single National Health Service trust during 2005. By univariate analysis twenty variables were found to be associated with postoperative length of stay as a continuous variable, and as a categorical dichotomy of either less than or equal to five days or more than five days. Multivariate analysis of these variables showed that both postoperative length of stay and discharge within five days of surgery were poorly predicted. However, the models developed were much better at predicting postoperative lengths of stay greater than five days. Phase II Another cohort of 503 patients was used to prospectively validate the models. The potential influence of perceived stress and health locus of control was also investigated. These variables were not associated with either outcome. This study identified areas for further research, including the potential of other psychosocial variables to improve the predictive ability of the models. This would increase the utility of the models in practice and contribute to improvements in both the quality of the patient journey and the business objectives of healthcare organisations.
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Rojo, Xicart Ernest. "Soft tissue volume gain around dental implants after abutment connection surgery using autogenous subepithelial connective tissue grafts harvested from the palate or tuberosity. A randomized prospective clinical study." Doctoral thesis, Universitat Internacional de Catalunya, 2017. http://hdl.handle.net/10803/586354.
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The aim of the present study is to compare the volume gain around dental implants when a subepithelial connective tissue graft (SCTG) from palate or tuberosity is used randomly. The most studied donor area for soft tissue augmentation has been the autogenous connective tissue from the palate. However recent studies has affirmed that tuberosity tissue may possess better tissue qualities for soft tissue volume augmentation.
It has been shown that tuberosity connective tissue is more dense with less fat and glandular tissue. Therefore, it could be speculated that this firmer tissue will have less shrinkage and achieve more soft tissue gain.
In the present study 32 patients with 36 implants with localized volume deficiency has been included and received randomly a SCTG from palate or tuberosity. Measurements using an intraoral optical scan has been done at baseline and 3 months. Also 20 samples were obtained at baseline for immunohistochemistry and descriptive histological analysis.
In conclusion both groups obtained volume gain at 3 months. No statistical significant differences were found. Even though a tendency of better results was observed for patients who received SCTG from tuberosity.<br>L’objectiu del present estudi es comparar el guany de volum al voltant d’implants dentals després d’haver utilitzat aleatoriament injert de teixit conectiu subepitelial de paladar o de tuberositat. L’àrea donant més utilitzada per realitzat procediments d’augment gingival ha estat sempre la zona del paladar. Tot i que estudis recents han demostrat que la zona de la tuberositat pot ser una bona alternativa degut a que pot tenir millors propietats per l’augment gingival.
S’ha demostrat darrerament que el teixit conectiu de la tuberositat és més dens i conté menys teixit gras i glandular. Això pot comportar que aquest teixit no es contraigui tant i que per tant pugui aconseguir millors resultats en quant a guany de volum.
En aquesta investigació 32 pacients portadors de 35 implants amb defecte de volum vestibular han rebut cirugía d’augment de teixit tou utilitzant injert de teixit conectiu de paladar o tuberositat. S’han realitzat mesures utilitzant un escáner intraoral a l’inici de l’estudi i 3 mesos després. També s’ha realitzat estudi histològic i d’immunohistoquímica de 20 mostres.
Com a conclusió, els dos grups de l’estudi han aconseguit guanyar volum de teixit tou als 3 mesos. No s’han detectat diferencies estadísticament significatives entre els grups. Tot i així s’ha observat una tendencia a millors resultats en el grup de pacients que han rebut injert de teixit tou de la tuberositat.
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Stuewe, Paul. "Britishers at home and overseas, imperial and colonial identity in the work of Grant Allen, Robert Barr and Sir Gilbert Parker." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ51230.pdf.
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Grant, Brenna Beth. "US and Canadian cattle markets: integration, the law of one price, and impacts from increased Canadian slaughter capacity." Thesis, Montana State University, 2007. http://etd.lib.montana.edu/etd/2007/grant/GrantB0507.pdf.
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The objectives of this study are to econometrically determine if the US and Canadian fed steer, feeder steer, and slaughter cow markets were integrated from 1985 to 2006. The law of one price was tested for individually defined policy regimes. Price transmission and exchange rate pass-through are tested in each regime to determine the degree of market integration for each cattle market. Regimes are tested for changes in market structure to determine if the policy change had been significant. The increase in Canadian slaughter capacity is then quantified on cattle prices in Canada and the US. All cattle markets were integrated from 1985 to 2006. However, while the markets were found to be integrated they are not perfectly integrated because of imperfect price transmission and incomplete exchange rate pass-through. The LOP held pre-CUSTA for all markets, and post-1995 for the fed steer and feeder steer markets. The LOP is rejected in the post-CUSTA regime for all markets. LOP results are indeterminate for post-2003 and are rejected for the post-2005 period, as expected because of limited trade. The Wald test indicated that all policy changes were significant. The fed steer market was the most responsive to policy changes and have the most animals traded. Expansion of Canadian slaughter capacity resulted in a small increase in Canadian prices for all cattle markets. The largest increase was in the fed steer market and the smallest in the feeder steer market. These increases are very small economically even though they are statistically significant. There was no initial impact on US cattle prices from increasing Canadian slaughter capacity and this may be because of the Canadian packing plants operating at less than full capacity. In the long-run the US slaughter cow market saw a very small increase in price, but the fed and feeder steer markets remained unaffected. And that is probably because they are much larger then the Canadian market.
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Densmore, Emily Jane. "Recovery from depression through mindfulness| A grant proposal." Thesis, California State University, Long Beach, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10099854.
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<p> Depression affects over 16 million adults in the United States every year. Furthermore, depression is a chronic and reoccurring disorder for more than half of the individuals who experience it. There are various treatment options for depression; however, many people are unable to achieve long-term recovery from the disorder. Mindfulness-based cognitive therapy (MBCT) is an evidence-based intervention that significantly reduces the rates of depression relapse. The purpose of this project was to obtain funding to implement an on-going MBCT group at Hoag Memorial Hospital Presbyterian’s Mental Health Center in Orange County, California. The goals of the group are to prevent depression relapse by helping participants develop and maintain positive coping skills, learn to be accepting of their thoughts and feelings, and become more compassionate towards their experiences. Included in this project is a literature review, suggested funder, staffing pattern, implementation timeline, evaluation strategy, and budget. Submission of the grant was not a requirement for this project.</p>
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Fluck, Nicholas C. "Immunological events resulting from intrathymic delivery of alloantigen." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312492.
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Hall, Katherine C. "Patient Perspectives of Bed Bathing: From Idea to Grant Proposal." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/8296.
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El-Sheemy, Mohamed Adbo. "The effects of extracts from the human dermis on the ability of the human fibroblasts to cause contraction in vitro." Thesis, University of Aberdeen, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323397.
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The starting point of this investigation was the clinical observation that raw areas of the body resurfaced by split-thickness skin grafts contract markedly, whereas those covered by thick grafts (e.g. Wolfe grafts) contract little or not at all. The reason for this behaviour is unknown. The present work was an attempt to investigate this behaviour using fibroblasts cultured in a hydrated collagen lattice (FHCL) as a laboratory model for wound contraction in vivo. Sequential extracts of normal human dermis were prepared in water, 0.15M sodium chloride, 1M sodium chloride, 0.15M citrate buffer (pH 3.5) and 6M urea, and their effects on FHCL contraction were examined. Only citrate buffer dermal extract had a marked inhibitory effect on FHCL contraction. The effect was reversible, concentration-dependent and lasted throughout the course of the 96 hours' experiments. There was no toxic effect on the cells although their proliferation within the lattices was also inhibited. Furthermore the extracts from the deeper parts of the dermis have more inhibitory effect on the FHCL contraction than those from the more superficial layers. Preliminary attempts to characterise the citrate buffer dermal extract biochemically showed the presence of protein and proteoglycans or glycosaminoglycans with a range of molecular weights showed by gel electrophoresis, and the presence of collagen was excluded by amino acid analysis. This study shows that there is a biochemical factor (factors) present in the dermis which inhibits the ability of fibroblasts to cause lattice contraction. This factor (s) can be extracted by citrate buffer. The inhibitory effect of the citrate buffer dermal extract on lattice contraction is due to inhibition of both fibroblasts proliferation and migration.
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Giordana, Sergio. "Geometrical reconstruction from medical images, classification and modelling of arterial by-pass grafts." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411719.
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Rose, Carolyn June. "Quantitative analyses of plant remains from the NAN Ranch Ruin, Grant County, New Mexico." Thesis, Texas A&M University, 2004. http://hdl.handle.net/1969.1/1262.
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The general architectural transition from semi-subterranean pithouses to surface pueblos that occurred across the prehistoric North American Southwest has been attributed to increased agricultural dependence. In this study macrobotanical ubiquity scores, percentages, diversity, and richness were compared between pithouse and pueblo assemblages from the NAN Ranch Ruin, Grant County, New Mexico, to assess whether or not the macrobotanical evidence supported a link between increased agricultural dependence and the pithouse to pueblo transition at the site. Rarely were differences between values of relative macrobotanical abundance from the two periods found to be significant. Ubiquity analyses provided some evidence for greater agricultural dependence in the pueblo period. Ubiquity scores declined between the pithouse and pueblo periods for all taxa recovered from both periods, except maize (Zea mays L.) and goosefoot (Chenopodium spp.), an aggressive agricultural weed, probably because the puebloan occupants of the NAN Ranch Ruin relied more on maize agriculture than did the pithouse occupants at the site. Cotton (Gossypium hirsutum L.) was recovered only from pueblo deposits, perhaps indicating that this crop was not grown during the earlier pithouse period. Significant differences that were detected between pithouse and pueblo values of relative macrobotanical abundance were most likely due to the effect of variable sample sizes, when all samples were combined for analysis, regardless of their recovery contexts. Although the effect of variable sample volume was controlled by analysis of sub-samples representing five liters of excavated soil, the sub-samples varied in the number of specimens present. This finding illustrates the effect of variable numbers of specimens per sample on measures of relative abundance and the importance of comparing similar contexts in quantitative studies.
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Gava, Renato Jacob. "Análise de campo médio para um modelo epidêmico via passeios aleatórios em um grafo." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/45/45133/tde-12092014-120618/.
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Estudamos sistemas de passeios aleatórios sobre os vértices de um grafo completo. Inicialmente há uma partícula em cada vértice do grafo das quais somente uma está ativa, as outras estão inativas. A partícula ativa realiza um passeio aleatório simples a tempo discreto com tempo de vida que depende do passado do processo, movendo-se ao longo de elos. Quando uma partícula ativa encontra uma inativa, esta se ativa; quando salta sobre um vértice já visitado, morre. O objetivo desta dissertação é estudar a cobertura do grafo completo, ou seja, a proporção de vértices visitados ao fim do processo, quando o número $n$ de vértices tende ao infinito. Analisamos as equações de campo médio para o processo descrito acima, comparando os seus resultados com os do modelo aleatório. Aqui, os resultados do campo médio parecem reproduzir os do modelo aleatório. Depois, apresentamos um estudo similar entre o modelo estocástico e as equações de campo médio para o caso em que cada partícula possui 2 vidas. Finalmente, observamos a cobertura do grafo completo para as equações de campo médio quando o número de vidas por partículas é maior que dois.<br>We study random walks systems on complete graphs. Initially there is a particle at each vertex of the graph; only one is active and the other are inactive. An active particle performs a discrete-time simple random walk with lifetime depending on the past of the process moving along edges. When an active particle hits an inactive one, the latter is activated. When it jumps on a vertex which has been visited before it dies. The goal of this work is to study the coverage of the complete graph, that is, the proportion of visited vertices at the end of the process, when the number of vertices goes to infinity. We analyze the mean field equations to the process cited above, comparing their results with the ones of the random model. Here the results of the mean field approach seem to reproduce the ones of the random model. After we present a similar study between the stochastic model and mean field approximation to the case that each particle has 2 lifes. Finally we observe the coverage of the complete graph to the mean-field equations when the number of lifes by particle is bigger than two.
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Dooley, John E. "Defining the Mission of Virginia Cooperative Extension: An Interpretative Analysis From a Historical Perspective." Diss., Virginia Tech, 1998. http://hdl.handle.net/10919/30431.
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The study is an interpretative analysis of Virginia Cooperative Extension that examined the mission of the agency, as defined through its history and enabling acts of legislation. The study investigated how the mission has evolved during the eighty-four years of its existence. The study used the intent and context of the federal Smith-Lever legislation of 1914 as its benchmark to discover what the desired and anticipated outcomes were for Cooperative Extension by the original patrons of the legislation. Subsequent legislative acts at both the state and federal levels, as well as actions by the executive branch of government, were studied to discover if and when the mission of cooperative extension has changed and to identify the political, economic, and social factors that influenced the changes.
The study incorporated accepted methods of historical research and included the review and analysis of both primary and secondary sources of information. Interviews of key leaders who have influenced the policy position of Virginia Cooperative Extension over the past thirty years were conducted.
The data gathered by the study were analyzed and presented to highlight major themes that could have influenced critical policy issues that have confronted Virginia Cooperative Extension. The conclusion is that the mission of extension is two fold: (1) to provide education that could lead to increased economic opportunity and, (2) to enhance the quality of life enjoyed by Virginia’s citizens.
Three critical attributes are identified that relate to the ability of Virginia Cooperative Extension to fulfill its mission: (1) access to research-based information, (2) a strong presence in local communities, and (3) a capacity to provide timely responses to emerging issues.<br>Ph. D.
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Renteria, Yadira. "Respite services for post-adoption families transitioning from the child welfare system| A grant proposal." Thesis, California State University, Long Beach, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10004148.
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<p> The purpose of the grant proposal was to collaborate with a host agency to incorporate respite care as an additional support for post-adoption families adopting from the Los Angeles child welfare system. A literature review was conducted to examine the needs and challenges of post adoptive families as well as the benefits of respite care within other populations faced with similar needs and challenges. The respite care program will be implemented at Olive Crest in Los Angeles County as part of the Adoption Promotion and Support Services Program (APSS). The goal of this program is to provide additional supportive services to parents caring for children with special needs and prevent adoption disruption or dissolution. Submission and funding of this grant was not a requirement for the completion of the project.</p>
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Sciantarelli, Jennifer Ann. "The NEA and the dance field an analysis of grant recipients from 1991 to 2000 /." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1230571780.
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Hurley, D., Ryan Andrew Nivens, Rosemary Geiken, and Renée Rice Moran. "How to Write a Successful RDC Grant for Funding: Lessons from a Panel of Awardees." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/241.
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Sciantarelli, Jennifer Ann. "The NEA and the Dance Field: An Analysis of Grant Recipients from 1991 to 2000." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1230571780.
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Xiang, Lina. "The development of artificial artery and artificial uterus from the peritoneal-derived tissue capsule /." [St. Lucia, Qld], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18118.pdf.
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Dudley, Eric. "From Capitol Hill and West Point: an examination of Ulysses S. Grant’s subordinate generals." Thesis, Kansas State University, 2012. http://hdl.handle.net/2097/13619.
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Master of Arts<br>Department of History<br>Charles Sanders<br>This thesis examines the relationships of Ulysses S. Grant and four of his subordinate generals. Ultimately, it is a command study of General Grant that analyzes how he managed his subordinates. The four individuals that this thesis examines are John Alexander McClernand, John Alexander Logan, James Birdseye McPherson, and Gouverneur Kemble Warren. These individuals provide an excellent balance between professional generals from West Point and volunteer generals with political backgrounds. The survey also balances the degrees of success experience by the four subordinates. The thesis traces each subordinate general during the Civil War, their relationship with Grant, and evaluates Grant’s management of each individual. Finally, the thesis identifies certain characteristics that Grant sought in a subordinate general. Taken as a whole, the thesis provides several lessons on the politics of the Union Army’s command structure during the Civil War, thoroughly covers the experiences of each individual subordinate while serving under Grant, and offers valuable insight on the overall generalship of Ulysses S. Grant. The thesis concludes that Grant was an effective manager of his subordinate generals and that his management also transcended his personal preference of West Point graduates. The thesis also identifies proper subordination, aggressive command style, the ability to effectively and efficiently carry out his orders, and trustworthiness as the qualities that Grant sought in his subordinates.
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Zwane, Dudu Elizabeth. "Caregivers' views on the contributing factors of malnutrition among children benefiting from the Child Support Grant." Diss., University of Pretoria, 2015. http://hdl.handle.net/2263/53479.
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The scourge of malnutrition in children under the age of five remains a worldwide problem resulting in deaths that could have been prevented with a proper paediatric diet.
Despite various national nutrition and primary health care programmes in South Africa over the last 10 years, recent studies show that child malnutrition has contributed to the deteriorating health of children below the age of five. At national level, stunting and underweight remain the common nutritional disorders affecting one out of five children in South Africa.
Very limited research has been done on the role of caregivers in reducing the scourge of malnutrition. The study focused on exploring and describing the views of caregivers on the contributing factors of malnutrition among children who are under the age of five benefiting from the Child Support Grant.
A qualitative, explorative study was conducted, with the following objectives:
· To conceptualise malnutrition as a social phenomenon and to explore strategies of alleviating malnutrition with specific emphasis on the Child Support Grant.
· To determine caregivers understanding of malnutrition among children<br>Mini Dissertation (MSW)--University of Pretoria, 2015.<br>Social Work and Criminology<br>MSW<br>Unrestricted
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Miranda, Eduardo de Paula 1984. "Linked biology = from phenotypes towards phylogenetic trees." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/275498.
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Orientador: André Santanchè<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Computação<br>Made available in DSpace on 2018-08-24T12:38:30Z (GMT). No. of bitstreams: 1
Miranda_EduardodePaula_M.pdf: 3021722 bytes, checksum: 93a67943f673753c003a021060a55b6c (MD5)
Previous issue date: 2013<br>Resumo: Um grande número de estudos em biologia, incluindo os que envolvem a reconstrução de árvores filogenéticas, resultam na produção de uma enorme quantidade de dados -- por exemplo, descrições fenotípicas , matrizes de dados morfológicos , árvores filogenéticas, etc. Biólogos enfrentam cada vez mais o desafio e a oportunidade de efetivamente descobrir conhecimento a partir do cruzamento e comparação de vários conjuntos de dados, nem sempre conectados e integrados. Neste trabalho, estamos interessados em um contexto específico da biologia em que biólogos aplicam ferramentas computacionais para construir e compartilhar descrições digitais dos seres vivos. Nós propomos um processo que parte de fontes de dados fragmentadas, que nós mapeamos para grafos, em direção a uma plena integração das descrições através de ontologias. Os bancos de dados de grafos intermediam o processo de evolução. Eles são menos dependentes de esquema e, uma vez que ontologias também são grafos, o processo de mapeamento do grafo inicial para uma ontologia torna-se uma sequência de transformações no grafo. Nossa motivação parte da ideia de que a conversão de descrições fenotípicas em uma rede de relações e a busca de conexões entre elementos relacionados irá aumentar a capacidade de resolver problemas mais complexos suportados por computadores. Este trabalho detalha os princípios de concepção por trás do nosso processo e duas implementações práticas como prova de conceito<br>Abstract: A large number of studies in biology, including those involving phylogenetic trees reconstruction, result in the production of a huge amount of data -- e.g., phenotype descriptions, morphological data matrices, phylogenetic trees, etc. Biologists increasingly face a challenge and opportunity of effectively discovering useful knowledge crossing and comparing several pieces of information, not always linked and integrated. In this work, we are interested in a specific biology context, in which biologists apply computational tools to build and share digital descriptions of living beings. We propose a process that departs from fragmentary data sources, which we map to graphs, towards a full integration of descriptions through ontologies. Graph databases mediate this evolvement process. They are less schema dependent and, since an ontology is also a graph, the mapping process from the initial graph towards an ontology becomes a sequence of graph transformations. Our motivation stems from the idea that transforming phenotypical descriptions in a network of relationships and looking for links among related elements will enhance the ability of solving more complex problems supported by machines. This work details the design principles behind our process and two practical implementations as proof of concept<br>Mestrado<br>Ciência da Computação<br>Mestre em Ciência da Computação
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Peltier, Linda. "Development of third party grafts from pooled CD34- selected cryopreserved cord blood units for stem cell transplantation." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123051.
Full textAbstract:
Umbilical cord blood (CB) is a valuable alternative source of stem cells for patients who do not have a compatible donor for allogeneic stem cell transplantation. Unfortunately, few banked cord blood units contain sufficient hematopoietic stem cells to transplant adult patients. Different approaches have been used to increase the number of infused HSC including the use of two or three HLA compatible CBUs, co-transplantation with related HLA haploidentical grafts to provide "third party" support, and cell expansion. These alternative approaches have the disadvantage of increasing the cost of graft procurement or relying on a related haploidentical donor that may not be available. I developed a method that aimed to increase the number of HSC available for transplantation by creating a third-party graft from pooled HLA-blind cryopreserved CBUs enriched for CD34+ cells. By using only CBUs rejected by the public cord blood bank, the cost of developing this mixed CBUs graft has been minimized. Over 60% of all collected CBUs do not qualify for public banking and could potentially be salvaged to create third-party grafts for clinical use. To pursue this project, it was necessary to establish a clinical grade research cord blood bank to ensure the availability of CBUs for experimental graft development. This project covered all aspects of cord blood banking from screening potential mothers, to CBU collection, processing, cryopreservation, and release of CBUs for transplantation. From October 2007 to December 2012, 2313 CBUs have been collected. Approximately 38% of the collected CBUs qualified for the Québec public cord blood bank and 1418 CBUs were retained. A small volume of CBUs did not qualified for any banking mainly due to a volume of less than 20 mL, CBUs being more than 96 hours post collection or positive bacteriology/serology testing. Some of the key accomplishments that permitted the successful creation of mixed cord blood grafts were the development of pooling methods to minimize the toxicity of the cryopreservative DMSO while simultaneously thawing and combining multiple CBUs. I also observed that passive transfer of anti-A and anti-B immunoglobulin-gamma could bind ABO-incompatible fetal leukocytes and potentially interfere with cell yields and function. The quality of mixed cord blood grafts was optimized by dilution of thawed CBUs to reduce DMSO concentration from 10% to 1% and selecting CBUs that had maternal-fetal ABO compatibility. Mixed cord blood grafts using from 12 to 45 CBUs were pooled with a mean nucleated cell recovery of 87% post-thawing and 73% post-centrifugation with a yield of CD34+ cells, sufficient for third party support in allogeneic cord blood transplantation. The safety and utility of using mixed cord blood grafts for allogeneic stem cell transplantation has been demonstrated in a clinical trial developed and conducted at the MUHC. Seven recipients with hematological cancers received, after myeloablative conditioning, a ≥ 4/6 HLA compatible CBU, followed by infusion of the third-party graft containing on average 2.5 x 105 CD34+ cell/kg. The median neutrophil engraftment time was 19.5 days. One patient had primary graft failure. All engrafted patients showed a 100% HLA-matched donor chimerism at first assessment on day +14. Six patients were alive at day +100 while one patient died at day +28 of disease relapse. All engrafted recipients developed grade I-III acute graft-versus-host-disease that responded promptly to treatment and no patients developed chronic GVHD.These results demonstrate that increasing the number of HSCs by using third-party cells from pooled HLA-blind CBUs to support a ≥ 4/6 HLA compatible CBU is safe, feasible, and results in rapid engraftment. Future studies are warranted to better understand the role of pooled third party units and factors involved in the homing of stem cells to their natural niche to facilitate the selection of units for engraftment.<br>Le sang du cordon ombilical (SC) est une précieuse source de cellules souches (CS) pour les patients n'ayant pas de donneur allogénique. Une unité de SC contenant suffisamment de CS hématopoïétiques (CSH) pour transplanter des patients de taille adulte est limitée. Différentes approches ont été utilisées pour augmenter le nombre de CS transplantées, y compris l'utilisation de deux SCs HLA-compatible, la co-transplantation d'un SC avec une unité HLA haplo-compatible nommée « tierce partie » et l'expansion de SC. Ces approches augmentent le coût d'acquisition du greffon ou nécessitent la disponibilité d'un donneur apparenté limitant ainsi leur application.J'ai développé une méthode qui vise à augmenter le nombre de CSH par la création d'une unité nommée « tierce partie » composée de cellules CD34+ provenant du regroupement d'USCs cryopréservées dont la compatibilité HLA est inconnue. En utilisant uniquement les USCs rejetées par la banque publique de sang de cordon, le coût de développement de ce type de greffon est minimal tout en réduisant le gaspillage des dons de sang de cordon. Le développement d'un tel projet a exigé l'établissement d'une banque de sang de cordon afin d'assurer la disponibilité d'USCs. Tous les aspects de la banque de sang de cordon ont été mis en place incluant l'approche des futures mères, la collecte des USCs, la manipulation, la congélation, et la libération d'USCs pour la transplantation. Entre octobre 2007 et décembre 2012, 2313 USCs ont été prélevées. Environ 38% de ces SC se sont qualifiées pour la banque publique et 1418 USCs sont demeurées pour la recherche. Une infime quantité d'USCs (8.6%) n'ont pu se qualifier pour aucune des deux banques, principalement dû aux raisons suivantes : un volume de moins de 20 mL, des USCs collectées de plus de 96 heures ou le résultat positif de bactériologie/sérologie.Parmi les principales réalisations, j'ai développé une méthode regroupant de multiples USCs tout en minimisant la toxicité du DMSO après la décongélation. Le transfert passif d'immunoglobuline-gamma anti-A/B pouvant se fixer aux leucocytes ABO-incompatibles a également été observé, ce qui peut potentiellement interférer avec la récupération des cellules regroupées ainsi qu'avec leurs fonctions. La qualité des greffons d'USCs regroupées a été optimisée par la dilution des USCs décongelées réduisant la concentration du DMSO de 10% à 1% et par la sélection d'USCs ayant une compatibilité ABO materno-fœtale. Les greffons ont requis le regroupement de 12 à 45 USCs, dont la récupération moyenne de cellules nucléées a été de 87% après la décongélation et de 73% après la centrifugation. Cette méthode a permis d'obtenir un nombre suffisant de cellules CD34+ en tant que « tierce partie » pour soutenir la transplantation allogénique d'USC. Sept receveurs ont reçu, après conditionnement myéloablatif, une USC 4/6 ou 5/6 HLA-compatible, suivie d'une infusion d'une unité « tierce partie » contenant en moyenne 2.5 x 105 cellules CD34+/kg. Le temps moyen de prise de la greffe des neutrophiles était de 19.5 jours. Un seul patient a rejeté le greffon. Tous les patients greffés ont démontré un chimérisme de 100% du donneur HLA-compatible lors de la première évaluation faite au jour +14. Six patients étaient vivants au 100e jour, alors qu'un patient est décédé au 28e jour, d'une rechute aigüe de sa leucémie. Tous les receveurs greffés ont développé une maladie aigüe de la greffe contre l'hôte de grade I à III et aucun patient n'a développé une GVHD chronique.Ces résultats démontrent que l'augmentation du nombre de CSH par l'utilisation d'une unité « tierce partie » provenant du regroupement d'USCs HLA-inconnus pour soutenir une USC ≥ 4/6 HLA compatible est sécuritaire, faisable. Des études futures sont requises afin de mieux comprendre le rôle de l'unité « tierce partie » ainsi que les facteurs impliqués dans la domiciliation des CS afin de faciliter la sélection des unités pour une greffe.
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Barrera, Campo Jos e. Fernando. "Multimodal Stereo from Thermal Infrared and Visible Spectrum." Doctoral thesis, Universitat Autònoma de Barcelona, 2012. http://hdl.handle.net/10803/117596.
Full textAbstract:
Recientes avances en im agenes t ermicas (LWIR) han permitido su uso en aplicaciones
m as all a del ambito militar. Actualmente, esta nueva familia de sensor esta
siendo incluida en diversas aplicaciones tanto t ecnicas como cient cas. Este tipo
de sensores facilitan tareas tales como: detecci on de peatones, puntos calientes, detecci
on de cambios de temperatura, entre otros. Caracter sticas que pueden mejorar
signi cativamente el desempeo de un sistema, especialmente cuando hay interacci on
con humanos. Por ejemplo, aplicaciones de v deo vigilancia, detecci on de peatones,
an alisis de postura.
En esta tesis se plantea entre otras la siguiente pregunta de investigaci on: Podr a
un par de sensores operando en diferentes bandas del espectro electromagn etico, como
el visible e infrarrojo t ermico, proporciona informaci on de profundidad? Si bien es
una cuesti on compleja, nosotros demostramos que un sistema de estas caracter sticas
es posible. Adem as, de discutir sus posibles ventajas, desventajas y oportunidades
potenciales.
La fusi on y correspondencia de los datos procedentes de diferentes sensores, como
las emisiones registradas en la banda visible e infrarroja, representa un reto atractivo,
ya que se ha demostrado que aquellas se~nales est an d ebilmente correlacionadas. Por
lo tanto, muchas t ecnicas tradicionales de procesamiento de im agenes y visi on por
computadora son inadecuadas, requiriendo ajustes para su correcto funcionamiento.
En esta investigaci on se realizo un estudio experimental comparando diferentes
funciones de costos multimodal, y t ecnicas de correspondencia, a n de construir un
sistema est ereo multimodal. Tambi en, se identi c o el problema com un entre est ereo
visible/ visible y infrarrojo/visible, particularmente en ambientes al aire libre. Entre
las contribuciones de esta tesis se encuentra; el aislamiento de las diferentes etapas
que componen un sistema est ereo multimodal. Esta arquitectura es gen erica a diferentes
niveles, tanto computacional, funcional y estructural, permitiendo su extensi on
a esquemas mas complejos tales como fusi on de alto nivel (sem antica) y de orden
superior (supuestos).
El enfoque propuesto est a destinado a explorar nuevos m etodos de correspondencia
est ereo, pasando de una soluci on escasa a una densas (tanto en disparidad como en
mapas de profundidad). Adem as, se ha incluido informaci on de contexto en forma
de asunciones y restricciones. Finalmente, esta disertaci on muestra un promisorio camino hacia la integraci on de m ultiples sensores.<br>Recent advances in thermal infrared imaging (LWIR) has allowed its use in applications
beyond of military domain. Nowadays, this new sensor family is included in
diverse technical and scienti c applications. They o er features that facilitate tasks,
such as detection of pedestrians, hot spots, di erences in temperature, among others,
which can signi cantly improve the performance of a system where the persons
are expected to play the principal role. For instance, video surveillance applications,
monitoring, and pedestrian detection.
During this dissertation is stated the next question: Could a couple of sensors
measuring di erent bands of the electromagnetic spectrum, as the visible and thermal
infrared, provides depth information? Although is a complex question, we shows that
a system of those characteristics is possible as well as their advantages, drawbacks,
and potential opportunities.
The fusion and matching of data coming from di erent sensors, as the emissions
registered at visible and infrared band, represents a special challenge, because it has
been showed that theses signals are weak correlated. Indeed, they are uncorrelated.
Therefore, many traditional techniques of image processing and computer vision are
not helpful, requiring adjustments for their correct performs in every modality.
In this research is performed a experimental study that compares di erent cost
functions and matching approaches, in order to build a multimodal stereo system. Furthermore,
are identi ed the common problem between visible/visible and infrared/visible
stereo, special in the outdoor scenes. A contribution of this dissertation is the isolation
achieved, between the di erent stage that compose a multimodal stereo system.
Our framework summarizes the architecture of a generic stereo algorithm, at di erent
levels: computational, functional, and structural, which is successful because this can
be extended toward high-level fusion (semantic) and high-order (prior).
The proposed framework is intended to explore novel multimodal stereo matching
approaches, going from sparse to dense representation (both disparity and depth
maps). Moreover, context information is added in form of priors and assumptions.
Finally, this dissertation shows a promissory way toward the integration of multiple
sensors for recovering three-dimensional information.
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Wang, Renhang, and Jialun Wu. "Patent use in Swedish small companies : Empirical evidence from a survey." Thesis, Uppsala universitet, Företagsekonomiska institutionen, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-418103.
Full textAbstract:
This thesis studies how small Swedish firms used their patents between 1998 to 2016. We also examine the association between used and unused patents and their characteristics such as technological class, family size, inventors, claims, grant and authority. Research data are collected from both databases (PATLINK, Serrano, and PATSTAT) and survey. We found that 79% of patents are used in small Swedish companies and family size is associated with patent use. In small Swedish companies, the increase in patent family size will decrease the frequency of use.