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Journal articles on the topic 'Graft rejection; Tumours; Autoimmune diseases'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Lee, Gap Ryol. "Phenotypic and Functional Properties of Tumor-Infiltrating Regulatory T Cells." Mediators of Inflammation 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/5458178.

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Regulatory T (Treg) cells maintain immune homeostasis by suppressing excessive immune responses. Treg cells induce tolerance against self- and foreign antigens, thus preventing autoimmunity, allergy, graft rejection, and fetus rejection during pregnancy. However, Treg cells also infiltrate into tumors and inhibit antitumor immune responses, thus inhibiting anticancer therapy. Depleting whole Treg cell populations in the body to enhance anticancer treatments will produce deleterious autoimmune diseases. Therefore, understanding the precise nature of tumor-infiltrating Treg cells is essential fo

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2

Storb, Rainer F., Guido Lucarelli, Peter A. McSweeney, and Richard W. Childs. "Hematopoietic Cell Transplantation for Benign Hematological Disorders and Solid Tumors." Hematology 2003, no. 1 (2003): 372–97. http://dx.doi.org/10.1182/asheducation.v2003.1.372.0010372.

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Allogeneic hematopoietic cell transplantation (HCT) has been successfully used as replacement therapy for patients with aplastic anemia and hemoglobinopathies. Both autologous and allogeneic HCT following high-dose chemotherapy can correct manifestations of autoimmune diseases. The impressive allogeneic graft-versus-tumor effects seen in patients given HCT for hematological malignancies have stimulated trials of allogeneic immunotherapy in patients with otherwise refractory metastatic solid tumors. This session will update the status of HCT in the treatment of benign hematological diseases and

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Storb, Rainer F., Guido Lucarelli, Peter A. McSweeney, and Richard W. Childs. "Hematopoietic Cell Transplantation for Benign Hematological Disorders and Solid Tumors." Hematology 2003, no. 1 (2003): 372–97. http://dx.doi.org/10.1182/asheducation-2003.1.372.

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Abstract Allogeneic hematopoietic cell transplantation (HCT) has been successfully used as replacement therapy for patients with aplastic anemia and hemoglobinopathies. Both autologous and allogeneic HCT following high-dose chemotherapy can correct manifestations of autoimmune diseases. The impressive allogeneic graft-versus-tumor effects seen in patients given HCT for hematological malignancies have stimulated trials of allogeneic immunotherapy in patients with otherwise refractory metastatic solid tumors. This session will update the status of HCT in the treatment of benign hematological dis

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4

Im, Ho Joon, Kyung Nam Koh, Jin Kyung Suh, et al. "Haploidentical Hematopoietic Stem Cell Transplantation in Pediatric Patients: Comparison of Early Post-Transplant Outcome According to in Vitro Depletion Method." Blood 124, no. 21 (2014): 1229. http://dx.doi.org/10.1182/blood.v124.21.1229.1229.

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Abstract Currently, haploidentical hematopoietic cell transplantation (HHCT) is considered an established option for patients who have diseases curable with HCT but who lack a suitable donor. We compared the early post-transplant outcomes of the two transplant groups using different in vitro depletion method. Between July 2008 and June 2014, 49 pediatric patients underwent in vitro T cell-depleted HHCT. Of 49 patients, 28 received CD3-depleted stem cells (CD3-HHCT) and 21 received TCRαβ-depleted grafts (TCRαβ-HHCT). Among 28 patients of CD3-HHCT, nine had hematologic malignancy [HM, one with A

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Emerson, Amy E., Emily M. Slaby, Shivani C. Hiremath, and Jessica D. Weaver. "Biomaterial-based approaches to engineering immune tolerance." Biomaterials Science 8, no. 24 (2020): 7014–32. http://dx.doi.org/10.1039/d0bm01171a.

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6

Bordron, A., A. Mankaï, B. Bendaoud, et al. "B Cell-Ablative Therapy: Where are We Now?" International Journal of Immunopathology and Pharmacology 20, no. 4 (2007): 655–59. http://dx.doi.org/10.1177/039463200702000401.

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Based on their multifaceted functions, B cells participate in several pathological settings such as lymphoproliferative disorders, autoimmune diseases and graft rejection. B cell-ablative therapy has thus emerged as a mainstay in these diseases. A number of anti-B cell antibodies (Abs) have been generated, among which anti-CD20 Abs appear to be efficient. Rituximab (RTX) is one of these anti-CD20 monoclonal Abs. Originally approved for the treatment of non-Hodgkin lymphoma, RTX is now being administered in other malignant proliferations, applied to an increasing number of autoimmune diseases a

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Niemand, Claudia, Carina Conrads, Ramona Siemer, and Mario Assenmacher. "Rapid Clinical Scale Isolation of CD25hiCD4+ Regulatory T Cells." Blood 104, no. 11 (2004): 4969. http://dx.doi.org/10.1182/blood.v104.11.4969.4969.

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Abstract Several publications during the last few years have reported CD25hiCD4+ regulatory T cells (Tregs) to prevent or to reverse disease in different mouse models of experimental autoimmune encephalomyelitis (EAE), colitis, graft rejection and graft-versus-host-disease (GvHD). As mouse and human Tregs share many phenotypical and functional characteristics, Tregs could provide a promising therapeutic approach for various human autoimmune diseases and pathological alloresponses. Here we have shown that Tregs can be isolated from leukapheresis harvests by CD25 enrichment using the CliniMACS t

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8

Jenh, Chung-Her, Mary Ann Cox, Long Cui, et al. "A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection." BMC Immunology 13, no. 1 (2012): 2. http://dx.doi.org/10.1186/1471-2172-13-2.

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9

Kaouther, Mnasria, and Oueslati Ridha. "Dendritic Cell-Based Graft Tolerance." ISRN Pharmacology 2011 (April 10, 2011): 1–4. http://dx.doi.org/10.5402/2011/347134.

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It has recently been demonstrated that mouse and human dendritic cells (DCs) can produce IL-2 after activation. However the role of the IL2/IL2R pathway in DC functions has not yet been fully elucidated. The results presented in this study provide several new insights into the role of this pathway in DCs. We report that stimulation of human monocyte-derived DCs with LPS strongly upregulated CD25 (α chain of the IL2R) expression. In additon, by using a humanized monoclonal antibody against CD25, we demonstrated that the IL2 signalling in DC upregulated both IL-12 and γIFN production but decreas

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Zulpaite, Ruta, Povilas Miknevicius, Bettina Leber, Kestutis Strupas, Philipp Stiegler, and Peter Schemmer. "Tryptophan Metabolism via Kynurenine Pathway: Role in Solid Organ Transplantation." International Journal of Molecular Sciences 22, no. 4 (2021): 1921. http://dx.doi.org/10.3390/ijms22041921.

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Solid organ transplantation is a gold standard treatment for patients suffering from an end-stage organ disease. Patient and graft survival have vastly improved during the last couple of decades; however, the field of transplantation still encounters several unique challenges, such as a shortage of transplantable organs and increasing pool of extended criteria donor (ECD) organs, which are extremely prone to ischemia-reperfusion injury (IRI), risk of graft rejection and challenges in immune regulation. Moreover, accurate and specific biomarkers, which can timely predict allograft dysfunction a

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11

Normanton, Marília, and Luciana Cavalheiro Marti. "Current data on IL-17 and Th17 cells and implications for graft versus host disease." Einstein (São Paulo) 11, no. 2 (2013): 237–46. http://dx.doi.org/10.1590/s1679-45082013000200019.

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Human interleukin 17 was first described in 1995 as a new cytokine produced primarily by activated T CD4+ cells that stimulate the secretion of IL-6 and IL-8 by human fibroblasts, besides increasing the expression of ICAM-1. Various authors have reported that IL-17A has a role in the protection of organisms against extracellular bacteria and fungi due to the capacity of IL-17A to recruit neutrophils to the areas of infection, evidencing a pathological role in various models of autoimmune diseases, such as experimental autoimmune encephalitis and arthritis. The participation of IL-17A has also

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12

Ostermann, D., N. Perico, O. Imberti, C. Barbui, M. Bontempelli, and G. Remuzzi. "Colchicine allows prolonged survival of highly reactive renal allograft in the rat." Journal of the American Society of Nephrology 4, no. 6 (1993): 1294–99. http://dx.doi.org/10.1681/asn.v461294.

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Colchicine, with its immunosuppressive properties, has been used with beneficial effects in autoimmune diseases. Whether colchicine, by virtue of the above properties, could attenuate the process of kidney allograft rejection in the rat is investigated in this report. Untreated Lewis rats (N = 6) given an incompatible kidney allograft from Brown-Norway rats rejected the graft within 12 days. Colchicine at a daily ip dose of 40 (N = 6) or 10 (N = 4) micrograms/kg promoted long-term survival (> 170 days) of major histocompatibility complex-incompatible kidney grafts. Animals (N = 4) given 4 m

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Jovanovic, Dijana. "Serum amyloid a in clinical practice." Srpski arhiv za celokupno lekarstvo 132, no. 7-8 (2004): 267–71. http://dx.doi.org/10.2298/sarh0408267j.

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Serum amyloid A (SAA) is an acute phase first class protein discovered a quarter of the century ago. Its concentration depends on clinical findings of the patient, illness activity and the therapy applied. SAA increases moderately to markedly (100-1000 mg/l) in bacterial and fungal infections, invasive malignant diseases, tissue injuries in the acute myocardial infarction and autoimmune diseases such as rheumatoid arthritis and vasculitis. Mild elevation (10-100 mg/l) is often seen in viral infections, systemic lupus erythematosus and localized inflammation or tissue injuries in cystitis and c

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14

Kappel, Lucy W., Gabrielle L. Goldberg, Christopher G. King, et al. "IL-17 contributes to CD4-mediated graft-versus-host disease." Blood 113, no. 4 (2009): 945–52. http://dx.doi.org/10.1182/blood-2008-08-172155.

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Abstract CD4+ interleukin-17 (IL-17)+ T cells (Th17 cells) have been implicated in allograft rejection of solid organs and several autoimmune diseases. However, the functional role of Th17 cells in the development of acute graft-versus-host disease (GVHD) has not been well-characterized. We detected significant numbers of alloreactive CD4+ donor T cells expressing IL-17, IL-17F, or IL-22 in the lymphoid organs of recipients of an allogeneic bone marrow transplant. We found no differences in GVHD mortality or graft-versus-tumor (GVT) activity between wild type (WT) and IL-17−/− T-cell recipient

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15

Baeke, Femke, Evelyne Van Etten, Lut Overbergh, and Chantal Mathieu. "Vitamin D3and the immune system: maintaining the balance in health and disease." Nutrition Research Reviews 20, no. 1 (2007): 106–18. http://dx.doi.org/10.1017/s0954422407742713.

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1,25-Dihydroxyvitamin D3(1,25(OH)2D3), the active form of vitamin D3, is a central player in Ca and bone metabolism. More recently, important immunomodulatory effects have been attributed to this hormone. By binding to its receptor, the vitamin D receptor, 1,25(OH)2D3regulates the expression of various genes and consequently affects the behaviour of different cell types within the immune system. 1,25(OH)2D3can potently inhibit pathogenic T cells and gives rise to elevated numbers of regulatory T cells via the induction of tolerogenic dendritic cells. These immunomodulatory activities of 1,25(O

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16

Geraud, Arthur, Paul Gougis, Aurore Vozy, et al. "Clinical Pharmacology and Interplay of Immune Checkpoint Agents: A Yin-Yang Balance." Annual Review of Pharmacology and Toxicology 61, no. 1 (2021): 85–112. http://dx.doi.org/10.1146/annurev-pharmtox-022820-093805.

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T cells have a central role in immune system balance. When activated, they may lead to autoimmune diseases. When too anergic, they contribute to infection spread and cancer proliferation. Immune checkpoint proteins regulate T cell function, including cytotoxic T lymphocyte antigen-4 (CTLA-4) and programmed cell death-1 (PD-1) and its ligand (PD-L1). These nodes of self-tolerance may be exploited pharmacologically to downregulate (CTLA-4 agonists) and activate [CTLA-4 and PD-1/PD-L1 antagonists, also called immune checkpoint inhibitors (ICIs)] the immune system.CTLA-4 agonists are used to treat

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17

Perseghin, Paolo. "Extracorporeal Photochemotherapy as a Challenging Treatment for Cutaneous T-Cell Lymphoma, Acute and Chronic Graft-versus-Host Disease, Organ Rejection and T-Lymphocyte-Mediated Autoimmune Diseases." Transfusion Medicine and Hemotherapy 35, no. 1 (2007): 8–17. http://dx.doi.org/10.1159/000111755.

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18

Oliveira, Régis Linhares, Pedro Cesar Chagastelles, Patrícia Sesterheim, and Patricia Pranke. "In Vivo Immunogenic Response to Allogeneic Mesenchymal Stem Cells and the Role of Preactivated Mesenchymal Stem Cells Cotransplanted with Allogeneic Islets." Stem Cells International 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/9824698.

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Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into cells from the mesenchymal lineage. The hypoimmunogenic characteristic of MSCs has encouraged studies using allogeneic MSCs for the treatment of autoimmune diseases and inflammatory conditions. Promising preclinical results and the safety of allogeneic MSC transplantation have created the possibility of “off-the-shelf” clinical application of allogeneic cells. This study has aimed to evaluate the survival of untreated and IFN-γ- and TNF-α-treated (preactivated) allogeneic MSCs transplanted under the kidney caps

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19

Kizhakayil, Dhanya, Abbirami Sathappan, Giusy Gentilcore, et al. "B-T Cell Interactions in GRAFT-Versus-Host Disease." Blood 136, Supplement 1 (2020): 38. http://dx.doi.org/10.1182/blood-2020-141277.

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Cytotoxic T cells (CTLs) and B cells engage distinct interactions in GVHD patients' blood and tissues, detectable in regular flow-cytometry screenings, by size and by double positive CD19-CD8 antibody markers (Deola, BMT 2017). B-CTL couplets are formed by alpha-betaTCR+ CD8+ CTLs preferentially targeting CD27+ CD19+ cells displaying an activated CD80 and CD86 phenotype. Interactions may last from 5 minutes to roughly 1 hour, and release a pattern of T cell attracting chemokines, as IP10, MIG, ITAC, which are also known GVHD biomarkers. To further unravel the mechanism of this cell interaction

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20

Gao, Wenda, Kenichiro Yamashita, Jennifer Sullivan, Abraham Scaria, Terry B. Strom, and Xian C. Li. "Adenovirus-Mediated PD-L1 Over-Expression Has Differential Effects on Allograft Survival in Murine Islet and Heart Transplant Models." Blood 104, no. 11 (2004): 4960. http://dx.doi.org/10.1182/blood.v104.11.4960.4960.

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Abstract Program death-1 (PD-1) is a negative regulator of the immune system. Blocking PD-1-mediated negative signaling accelerates autoimmune diseases, while engaging PD-1 with recombinant PD-L1Ig fusion protein potentiates the efficacy of co-stimulation blockade in prolonging allograft survival. However, soluble PD-L1Ig itself showed no graft-protecting effect, in contrast to its strong inhibition of T and B cell activation in vitro when applied in a plate-bound form. In this study, we tested the hypothesis that membrane-bound PD-L1 should prolong allograft survival due to its increased abil

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Vassiliadis, S., A. Ranella, L. Papadimitriou, A. Makrygiannakis, and I. Athanassakis. "Serum levels of pro- and anti-inflammatory cytokines in non-pregnant women, during pregnancy, labour and abortion." Mediators of Inflammation 7, no. 2 (1998): 69–72. http://dx.doi.org/10.1080/09629359891199.

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Disturbance of the cytokine equilibrium has been accused for many pathological disorders. Microbial infections, autoimmune diseases, graft rejection have been correlated to over- or under-production of specific cytokines which are produced as responder molecules to the various immune stimuli. The sole naturally occurring immune reaction in the organism is developed during the gestational period where, despite the presence of a semi-allogeneic graft, maternal immunoreactivity is driven to support fetal growth. The successful embryo development has been attributed to the important intervention o

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Taylor, Andrew W., and Darren J. Lee. "The Alpha-Melanocyte Stimulating Hormone Induces Conversion of Effector T Cells into Treg Cells." Journal of Transplantation 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/246856.

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The neuropeptide alpha-melanocyte stimulating hormone (α-MSH) has an important role in modulating immunity and homeostasis. The production of IFN-γby effector T cells is suppressed byα-MSH, while TGF-βproduction is promoted in the same cells. Suchα-MSH-treated T cells have immune regulatory activity and suppress hypersensitivity, autoimmune diseases, and graft rejection. Previous characterizations of theα-MSH-induced Treg cells showed that the cells areCD4+T cells expressing the same levels of CD25 as effector T cells. Therefore, we further analyzed theα-MSH-induced Treg cells for expression o

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BILOUS, V. L. "PRODUCTION AND APPLICATION OF ANGIOSTATINS FOR THE TREATMENT OF OCULAR NEOVASCULAR DISEASES." Biotechnologia Acta 14, no. 1 (2021): 5–24. http://dx.doi.org/10.15407/biotech14.01.005.

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Angiostatins comprise a group of kringle-containing proteolytically-derived fragments of plasminogen/plasmin, which act as potent inhibitory mediators of endothelial cells proliferation and migration. Angiostatins are involved in modulation of vessel growth in healthy tissues and various pathological conditions associated with aberrant neovascularization. The aim of the present paper was to summarize available information, including our own experimental data, on prospects of angiostatin application for treatment of ocular neovascular diseases (OND), focusing on retinal pathologies and corneal

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Feng, Xingmin, Elena E. Solomou, Keyvan Keyvanfar, et al. "Rabbit ATG but Not Horse ATG Promotes Expansion of Functional CD4+CD25highFoxP3 Regulatory T Cells In Vitro." Blood 110, no. 11 (2007): 2312. http://dx.doi.org/10.1182/blood.v110.11.2312.2312.

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Abstract CD4+CD25+ regulatory T cells (Treg) are believed to play important roles in suppressing immune responses and maintaining tolerance. Treg have the ability to prevent the development of autoimmune diseases, graft rejection and graft versus host disease (GVHD) in mice and perhaps also in humans. Immunosuppressive drugs such as rabbit ATG (rATG), horse ATG (hATG) and cyclosporine A (CsA) are widely used in conditioning for transplantation and for the treatment of autoimmune diseases and GVHD, but their effects on Treg remain to be fully elucidated. Lopez et al. (J Am Soc Nephrol. 2006;17:

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Luo, Xiaofeng, Jing Li, Juan Chen, Jocelyn A. Schroeder, Jianda Hu, and Qizhen Shi. "Platelet-Targeted Gene Transfer Prevents Graft Rejection and Induces Immune Tolerance Even in a Primed Model." Blood 128, no. 22 (2016): 2315. http://dx.doi.org/10.1182/blood.v128.22.2315.2315.

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Abstract Induction of antigen-specific immune tolerance is desirable in autoimmune diseases, transplantation, gene therapy, and some protein therapies in order to prevent or reverse adverse immune responses. Our previous studies have demonstrated that targeting FVIII or FIX expression to platelets under control of the platelet-specific aIIb promoter can restore hemostasis and induce immune tolerance in hemophilia mice. Here we explored if this approach can be applied to prevent graft rejection and induce immune tolerance to a non-coagulant protein even with pre-existing immunity. We used ovalb

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Maruf, Abdullah Al, Luke Wan, and Peter J. O’Brien. "Evaluation of Azathioprine-Induced Cytotoxicity in anIn VitroRat Hepatocyte System." BioMed Research International 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/379748.

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Azathioprine (AZA) is widely used in clinical practice for preventing graft rejection in organ transplantations and various autoimmune and dermatological diseases with documented unpredictable hepatotoxicity. The potential molecular cytotoxic mechanisms of AZA towards isolated rat hepatocytes were investigated in this study using “Accelerated Cytotoxicity Mechanism Screening” techniques. The concentration of AZA required to cause 50% cytotoxicity in 2 hrs at 37°C was found to be 400 μM. A significant increase in AZA-induced cytotoxicity and reactive oxygen species (ROS) formation was observed

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Ratnasingam, Sumita, Patricia A. Walker, Huy Tran, et al. "Bortezomib Yields High Response Rates in Antibody-Mediated Autoimmune Hematological Diseases Refractory to Conventional Immunosuppression." Blood 126, no. 23 (2015): 3457. http://dx.doi.org/10.1182/blood.v126.23.3457.3457.

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Abstract Introduction Certain patients with antibody-mediated autoimmune disease exhibit poor responses to conventional immunosuppression. Proteasome inhibitors (PI) have been prospectively evaluated in humoral graft rejection, where rapid alloantibody depletion occurs in the context of combined immunosuppression. In addition to killing antibody-producing cells, PIs deplete autoreactive T-cells, suppress inflammatory NFkB signaling and modulate MHC class I antigen presentation. The durability of rituximab-based B-cell depletion may be abrogated by promotion of long-lived autoreactive (CD20 neg

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Sun, Li, Naqvi, et al. "Succinate Coenzyme A Ligase Beta-Like Protein from Trichinella spiralis Suppresses the Immune Functions of Rat PBMCs in Vitro and Inhibits the Secretions of Interleukin-17 in Vivo." Vaccines 7, no. 4 (2019): 167. http://dx.doi.org/10.3390/vaccines7040167.

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: Succinate Coenzyme A ligase beta-like protein (SUCLA-β) is a subunit of Succinyl-coenzyme A synthetase, which is involved in substrate synergism, unusual kinetic reaction in which the presence of SUCLA-β for one partial reaction stimulates another partial reaction. Trichinella spiralis is a parasitic nematode, which may hinder the development of autoimmune diseases. Immunomodulatory effects of SUCLA-β from Trichinella spiralis in the parasite-host interaction are unidentified. In this study the gene encoding T. spiralis SUCLA-β was cloned and expressed. Binding activities of recombinant T. s

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Bar, Haim, and Seojin Bang. "A mixture model to detect edges in sparse co-expression graphs with an application for comparing breast cancer subtypes." PLOS ONE 16, no. 2 (2021): e0246945. http://dx.doi.org/10.1371/journal.pone.0246945.

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We develop a method to recover a gene network’s structure from co-expression data, measured in terms of normalized Pearson’s correlation coefficients between gene pairs. We treat these co-expression measurements as weights in the complete graph in which nodes correspond to genes. To decide which edges exist in the gene network, we fit a three-component mixture model such that the observed weights of ‘null edges’ follow a normal distribution with mean 0, and the non-null edges follow a mixture of two lognormal distributions, one for positively- and one for negatively-correlated pairs. We show t

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Massa, Margherita, Stefania Croce, Rita Campanelli, et al. "Clinical Applications of Mesenchymal Stem/Stromal Cell Derived Extracellular Vesicles: Therapeutic Potential of an Acellular Product." Diagnostics 10, no. 12 (2020): 999. http://dx.doi.org/10.3390/diagnostics10120999.

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In the last decade, the secreting activity of mesenchymal stem/stromal cells (MSCs) has been widely investigated, due to its possible therapeutic role. In fact, MSCs release extracellular vesicles (EVs) containing relevant biomolecules such as mRNAs, microRNAs, bioactive lipids, and signaling receptors, able to restore physiological conditions where regenerative or anti-inflammatory actions are needed. An actual advantage would come from the therapeutic use of EVs with respect to MSCs, avoiding the possible immune rejection, the lung entrapment, improving the safety, and allowing the crossing

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Palomar, Amaya Pérez del, Alberto Montolío, José Cegoñino, Sandeep Kumar Dhanda, Chit Tong Lio, and Tanima Bose. "The Innate Immune Cell Profile of the Cornea Predicts the Onset of Ocular Surface Inflammatory Disorders." Journal of Clinical Medicine 8, no. 12 (2019): 2110. http://dx.doi.org/10.3390/jcm8122110.

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Ocular surface inflammatory disorder (OSID) is a spectrum of disorders that have features of several etiologies whilst displaying similar phenotypic signs of ocular inflammation. They are complicated disorders with underlying mechanisms related to several autoimmune disorders, such as rheumatoid arthritis (RA), Sjögren’s syndrome, and systemic lupus erythematosus (SLE). Current literature shows the involvement of both innate and adaptive arms of the immune system in ocular surface inflammation. The ocular surface contains distinct components of the immune system in the conjunctiva and the corn

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Peritt, David, Kim Campbell, Amy Krutsick, et al. "Generation of Regulatory T Cells through Intravenous Delivery of Autologous Apoptotic Cells." Blood 104, no. 11 (2004): 2390. http://dx.doi.org/10.1182/blood.v104.11.2390.2390.

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Abstract Extracorporeal photopheresis (ECP) is approved for the palliative treatment of skin manifestations associated with cutaneous T cell lymphoma. As reported in the literature, ECP has shown promise as a treatment for such immune-mediated inflammatory disorders as graft versus host disease, transplantation rejection, and autoimmune diseases. ECP involves the reinfusion of autologous, apoptotic peripheral blood leukocytes treated ex vivo with 8-methoxypsoralen (8-MOP) and UVA light. The biological mechanism of action of ECP, however, remains unresolved. We have evidence to suggest that del

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Knobler, Robert M., Ulrike Just, Gabriele Klosner, et al. "Analysis of the Effect On the Expression of Global Gene Expression Profiles in Lymphocyte Subpopulations Treated by Extracorporeal Photopheresis." Blood 120, no. 21 (2012): 4841. http://dx.doi.org/10.1182/blood.v120.21.4841.4841.

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Abstract Abstract 4841 Introduction After the initial introduction of extracorporeal photopheresis (ECP) for the therapy of Sezary syndrome (CTCL) it has been found to have significant clinical effect on other T-cell mediated diseases including graft-versus-host disease (GvHD), organ transplant rejection, systemic sclerosis and other autoimmune disorders. To obtain information about modifications in gene expression patterns before and after ECP and to define gene sets with important changes in expression we analysed gene expression profiles in major lymphocyte subsets of patients before and af

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Djordjevic, Vidosava, Tatjana Cvetkovic, Ivana Stojanovic, et al. "Inter-dependence between cytokines and NO/NOS system in resting and activated endothelial cells." Jugoslovenska medicinska biohemija 23, no. 3 (2004): 241–47. http://dx.doi.org/10.2298/jmh0403241d.

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Cytokines are a heterogeneous and multifunctional group of molecules synthetized in various human cells. Structurally they are peptides (often glycosylated) used by cells for intercellular communication and control the inner environment of the cells in which they operate. Cytokines are produced by the cells involved in the immune response, inflammation, hemopoiesis, healing and systemic response to injury. Immunity, inflammatory reactions and haemostasis involve close interactions between immunocompetent cells and vascular endothelium. Vascular cells are both a target for cytokines and their s

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Fan, Huahua, Xiaona Huo, Juan Sun, Yiming Yang, and Xiao Li. "Efficient Induction and Expansion Of CD8+CD28+Foxp3+ Regulatory T Cells By TGF-beta1 and Rapamycin." Blood 122, no. 21 (2013): 190. http://dx.doi.org/10.1182/blood.v122.21.190.190.

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Abstract Background Although extensive studies have focused on the CD4+CD25+Foxp3+Tregs in recent years, CD8+Tregs have also been reported to play important roles in maintenance of immune tolerance. Adoptive transfer of CD8+Tregs in rodents can prevent or treat autoimmune diseases, allograft rejection or graft-versus-host disease. Objective Several approaches for induction of Ag-specific CD8+Tregs have been reported, but there is currently no reliable protocol for the ex vivo induction and large-scale expansion of human polyclonal CD8+CD28+Foxp3+Tregs. Our research was designed to investigate

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Sun, Zhengda, Haval Shirwan, Narendra Singh, Nadir Askenasy, and Esma S. Yolcu. "A Novel Approach to Prevent GvHD: Donor Cells Engineered to Display on Their Surface a Recombinant Form of FasL Protein Effectively Prevent Lethal GvHD in a Mouse Model." Blood 112, no. 11 (2008): 3519. http://dx.doi.org/10.1182/blood.v112.11.3519.3519.

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Abstract Allogeneic bone marrow transplantation (BMT) has the potential to cure a series of inherited and acquired hematological disorders and malignancies. BMT can also be used as a cell-based immunomodulatory approach to induce tolerance to foreign and auto-antigens for the prevention and/or treatment of foreign graft rejection and autoimmune disorders. The routine application of allogeneic BMT as a therapeutic intervention in the clinic, however, is complicated by graft-versus-host (GVH) reaction, which is the major cause of graft-versus-host disease (GVHD) with potential life-threatening c

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Hoebe, Kasper, Edith Janssen, and Bruce Beutler. "Identification of a Novel Toll-Like Receptor-Independent Immunoadjuvant Pathway That Depends upon Programmed Cell Death." Blood 104, no. 11 (2004): 775. http://dx.doi.org/10.1182/blood.v104.11.775.775.

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Abstract Molecules of microbial origin, and synthetic derivatives of these molecules, have long been used for their immuno-adjuvant effect, and as the key sensors of microbial infection, Toll-like receptors (TLRs) are thought to be essential for adjuvanticity. To the contrary, we now demonstrate the existence of a robust, TLR-independent pathway for adjuvant effect: one that is actually far stronger than the TLR-dependent pathway. Activation of Toll-like receptors (TLRs) and the subsequent production of cytokines such as type I interferon leads to the maturation of dendritic cells (DCs) with u

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Awada, Hassan, Reda Z. Mahfouz, Jibran Durrani, et al. "Long-Term Experience with Large Granular Lymphocytic Leukemia Evolving after Solid Organ and Hematopoietic Stem Cell Transplantation." Blood 134, Supplement_1 (2019): 1226. http://dx.doi.org/10.1182/blood-2019-130167.

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T-cell large granular lymphocyte leukemia (T-LGLL) is a clonal proliferation of cytotoxic T lymphocytes (CTL). T-LGLL mainly manifest in elderly and is associated with autoimmune diseases including rheumatoid arthritis (RA), B cell dyscrasias, non-hematologic cancers and immunodeficiency (e.g., hypogammaglobulinemia). LGL manifestations often resemble reactive immune processes leading to the dilemmas that LGLs act like CTL expansion during viral infections (for example EBV associated infectious mononucleosis). While studying a cohort of 246 adult patients with T-LGLL seen at Cleveland Clinic o

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Afzal, Amber, Maryna Tarbunova, George Despotis, and Brenda J. Grossman. "Comparison of Outcomes between the Cellex and Uvar-Xts Closed-System Extracorporeal Photopheresis (ECP) Devices When Used for Graft-Versus-Host Disease; A Single Center Experience." Blood 132, Supplement 1 (2018): 4686. http://dx.doi.org/10.1182/blood-2018-99-115122.

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Abstract BACKGROUND: Graft versus host disease (GVHD) is a significant contributor to non-relapse mortality after allogeneic stem cell transplant (SCT). Steroids are first line therapy and extracorporeal photopheresis (ECP) is used as second line therapy for steroid refractory or intolerant patients. ECP has immunomodulatory effects rather than immunosuppressive effect which decreases the risk of infection, and may decreases the risk of disease relapse. There are two ECP instruments approved in the US for the treatment of Cutaneous T Cell Lymphoma (CTLC), however both have been used "off-label

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Logan, Aaron C., Agnieszka Czechowicz, Benjamin V. Kelley та ін. "Anti-CD117 (c-Kit) Monoclonal Antibodies Deplete Human Hematopoietic Stem Cells and Facilitate Their Replacement in Humanized NOD/SCID/IL2Rγ−/− Mice: A Non-Toxic Conditioning Regimen for Allotransplantation". Blood 120, № 21 (2012): 4099. http://dx.doi.org/10.1182/blood.v120.21.4099.4099.

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Abstract Abstract 4099 Engraftment of allogeneic hematopoietic stem cells (HSC) requires conditioning to overcome immunologic and anatomic barriers preventing access to the marrow niche. Most patients who undergo allogeneic hematopoietic cell transplantation (allo-HCT) are prepared with cytotoxic chemotherapy and/or radiation to eliminate these barriers, and to facilitate eradication of malignant cells, if present. Many non-malignant conditions, such as primary immunodeficiencies, hemoglobinopathies, and autoimmune diseases may be successfully treated by transplantation of allogeneic HSC, but

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Marinelli Busilacchi, Elena, Andrea Costantini, Nadia Viola, et al. "In Vitro Comparison of Different TKI Activity in T-Cell Populations: Selective Sparing of Treg By Nilotinib." Blood 128, no. 22 (2016): 5774. http://dx.doi.org/10.1182/blood.v128.22.5774.5774.

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Abstract Introduction Chronic Graft Versus Host Disease (cGVHD) is a major complication of allogeneic stem-cell transplantation and is characterized by frequent multi-organ involvement that resembles the autoimmune diseases. Donor-derived CD4+ and CD8+ T lymphocytes have classically been considered to be the main effector cells mediating GVHD pathogenesis. Indeed, removal of T cells from transplant inocula almost completely prevents GVHD developing, at the price of increased incidences of graft rejection and disease recurrence. However recent studies suggest that B cells might also play an imp

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He, Shan, Fang Xie, Qing Tong, et al. "Histone Methyltransferase Ezh2 Controls T-Cell Immunity by Regulating Bioenergetic Metabolism." Blood 120, no. 21 (2012): 953. http://dx.doi.org/10.1182/blood.v120.21.953.953.

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Abstract Abstract 953 Adoptive T cell therapy has the potential to enhance antitumor immunity and improve vaccine efficacy, of which a key challenge is to generate sufficient numbers of T cells that can persist in vivo after transfer. Cellular metabolism plays important roles in regulating T cell proliferation and survival. T cells responding to antigen activation dramatically upregulate both glycolysis and oxidative phosphorylation (OXPHOS), leading to increased production of adenosine triphosphate (ATP) and metabolic intermediates that are required for cell growth and proliferation. Without

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Reich-Zeliger, Shlomit, Esther Bachar-Lustig, and Yair Reisner. "Effective Deletion of Anti-Donor Host Memory Effector Cells by Anti-3rd Party Veto CTLs: Implications to Tolerance Induction in Presensitized Bone Marrow Recipients." Blood 104, no. 11 (2004): 44. http://dx.doi.org/10.1182/blood.v104.11.44.44.

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Abstract Recently we demonstrated that veto CTLs enhance engraftment of mismatched T cell depleted BM in recipient mice following reduced intensity conditioning. This desirable tolerance induction can be further enhanced by combining veto CTLs with CD4+CD25+ cells and Rapamycin. While these results are encouraging, they were largely based on models in which the resistant effector T cells mediating the allorejection are naive CTLp. However, considering that many patients undergoing BMT are presensitized by transfusions of different blood products, memory T cells could play an important role in

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Garcia-Bernal, David, Miguel Blanquer, Jose Antonio del Rio, et al. "In Vitro Study of New Photochemotherapeutic Compounds for Extracorporeal Photopheresis." Blood 120, no. 21 (2012): 2144. http://dx.doi.org/10.1182/blood.v120.21.2144.2144.

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Abstract Abstract 2144 Introduction: Extracorporeal photopheresis (ECP) is a cell-based immunomodulatory therapy involving the separation of autologous mononuclear cell fraction followed by ex-vivo administration of 8-methoxypsoralen (8-MOP) and UVA irradiation before reinfusion. ECP is efficient for the treatment of cutaneous T-cell lymphomas, multiple skin disorders, autoimmune diseases, solid organ transplant rejection and graft versus host disease (GVDH). During UVA irradiation phase, 8-MOP binds covalently to leukocytes' DNA leading to cell cycle arrest and apoptosis. These pre-apoptotic

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Meng, Lijun, Zhenjiang Bai, Shan He, et al. "The Notch Ligand DLL4 Derived from Human Dendritic Cells Is Critical for Promoting T Helper (Th)1 and Th17 Cell Differentiation." Blood 126, no. 23 (2015): 3431. http://dx.doi.org/10.1182/blood.v126.23.3431.3431.

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Abstract Dendritic cells (DCs) are important for primary T cell responses, and cytokines produced by DCs are thought to be essential for promoting T helper (Th)1 and Th17 differentiation. However, DCs can drive effector differentiation independent of cytokines. In mouse models of graft-versus-host-disease (GVHD), which is a life-threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT), we found that DC-derived Notch ligand Dll4 was important for CD4+ Th1 and Th17 cell differentiation. Blocking Dll4 led to decreased production of IFN-g and IL-17 in mice receiving al

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Zaimoku, Yoshitaka, Bhavisha A. Patel, Sachiko Kajigaya, et al. "Deficit of Circulating CD19+CD24hiCD38hi Regulatory B Cells in Severe Aplastic Anemia." Blood 134, Supplement_1 (2019): 1219. http://dx.doi.org/10.1182/blood-2019-127053.

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Background: Immune aplastic anemia (AA) is caused by cytotoxic T cells (CTLs) that destroy hematopoietic stem and progenitor cells. Regulatory T cells (Tregs) are reduced in AA and increase in response to immunosuppressive therapy (IST; Solomou E et al, Blood 2007). Recent studies suggested an immune regulatory role of regulatory B cells (Bregs). Human CD19+CD24hiCD38hi Bregs suppress Th1 response of CD4+ T cells as well as IFN-γ production by CD8+ CTLs (Mauri C, Menon M, J Clin Invest 2017). The quantity and/or function of Bregs are impaired in autoimmune diseases, malignancies, chronic graft

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Hu, Yongxian, Yanjun Gu, Lixia Sheng та ін. "Decitabine Facilitates the Generation of Functional Regulatory γδT Cells Via Foxp3 Gene Demethylation and NF-κB up-Regulation". Blood 120, № 21 (2012): 3281. http://dx.doi.org/10.1182/blood.v120.21.3281.3281.

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Abstract Abstract 3281 Regulatory γδT cells (γδTregs) are capable of suppressing T-cell activation and proliferation (Rita et al Journal of immunology 2009). Our previous studies demonstrated the immunosuppressive features of γδTregs and further supported the use of γδTregs as a promising therapeutic strategy for the adoptive immunotherapy of allograft rejection, post-transplantation graft-versus-host disease (GVHD) and autoimmune diseases (Hu et al ASH abstract 2011). To this end, large-scale, efficient expansion of γδTregs represents a fundamentally important prerequisite for their clinical

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Miller, Weston, Caleb E. Wheeler, Angela Panoskaltsis-Mortari, et al. "Prevention of Acute GvHD During MHC Haploidentical BMT: Evaluating the Efficacy of T-Cell Costimulation Blockade Using a Novel Rhesus Macaque Transplant Model." Blood 114, no. 22 (2009): 2455. http://dx.doi.org/10.1182/blood.v114.22.2455.2455.

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Abstract Abstract 2455 Poster Board II-432 Introduction: While hematopoietic stem cell transplantation (HSCT) offers a cure for many hematologic diseases, it remains plagued by often fatal graft-versus-host disease (GvHD). Despite the inadequacy of current GvHD prevention strategies, especially for MHC-mismatched HSCT, the pace of the clinical introduction of novel therapeutics has been slow, likely due to the lack of a suitable translational model to rigorously test the immunologic and clinical impact of novel biologic therapies. Among the most promising of these therapies include those that

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Matos, Tiago R., Hongye Liu, Masahiro Hirakawa, Ana Cristina Alho, and Jerome Ritz. "Maturation and Phenotypic Diversity of Human CD4+ Regulatory T Cells in Umbilical Cord Blood and Peripheral Blood from Healthy Donors." Blood 126, no. 23 (2015): 2357. http://dx.doi.org/10.1182/blood.v126.23.2357.2357.

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Abstract Introduction: CD4+ FoxP3+ CD25+ regulatory T cells (Treg) are required for maintenance of immune tolerance and immune homeostasis. Quantitative or functional Treg deficiency has been correlated with autoimmune disease, allergy, allograft rejection and graft versus host disease. Conversely, increased Treg can suppress tumor immunity resulting in tumor progression. Treg express a large number of cellular markers that reflect their level of maturation, functionality, activation and migratory capacity. Nevertheless, it has not previously been possible to integrate the expression of these

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Sarkar, Debalina, Gongxian Liao, Cox Terhorst, and Roland W. Herzog. "Synergistic Effect of Flt3L and Rapamycin On Immune Tolerance Induction Via Plasmacytoid Dendritic Cells and Treg." Blood 120, no. 21 (2012): 2209. http://dx.doi.org/10.1182/blood.v120.21.2209.2209.

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Abstract Abstract 2209 In vivo induction and expansion of Treg is a powerful tool to limit unwanted immune responses and promote tolerance. For example, we have been successful inducing tolerance to factors VIII and FIX in hemophilic mice when the coagulation factor antigen was administered with the mTOR inhibitor rapamycin (J Thromb Haemost 7:1523 and 9:1524, Front Microbiol 2:244). Rapamycin, a macrocyclic triene antibiotic, is an immunosuppressant used to avoid transplant rejection. It suppresses the mTOR1 (and upon prolonged exposure also mTOR2) signaling pathway. Importantly, while mTOR b

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