Journal articles on the topic 'Grant loyiha'

Zamonaviy dunyoni iqtisodiy, ma’naviy, siyosiy va ijtimoiy jihatdan qamrab olgan globallashuv jarayoni ta’lim tizimiga ham o‘z ta’sirini o‘tkazmay qolmadi. Bu o‘zgarishlar butun dunyo ta’lim tizimini yagona yaxlitlikka olib kelishida ham o‘z aksini ko‘rsatdi. Ta’limning globallashuvi alohida katta tizim bo‘lganligi sababli, unga bosqichma-bosqich erishish mumkinligini va shu orqali tizimga o‘zimga xoslik kiritilishi kutilgan. So‘nggi yillarda ta’lim jarayonining deyarli barcha jabhalarini qamrab oluvchi katta o‘zgarishlar ro‘y bermoqda. Oliy taʼlim tizimi jamiyatdagi ijtimoiy talablarini qondirish uchun faoliyat yurituvchi eng muhim ijtimoiy institut boʻlib, u har qanday ijtimoiy oʻzgarishlar va jarayonlarga tez taʼsir koʻrsatadi.

Discussion of a project recently funded by a grant from the Martin Gang Institute for Intergroup Relations, an institute jointly administered by the American Jewish Committee Los Angeles and Loyola Marymount University Extension along with personal reflections.

Abstract Pope Gregory XV raised five holy persons to official sanctity in a grand ceremony in Saint Peter’s basilica in Rome on 12 March 1622. Three of the new saints were sixteenth-century Spanish contemporaries: the Discalced Carmelite Teresa of Ávila and the Jesuits Ignatius of Loyola and Francis Xavier. The saints were celebrated according to personas that were rooted in the framework of sanctity inherent to the processes for official holiness, that is, the official character of their deeds, virtues, and miracles. Setting aside miracles, this paper centers on Teresa’s deeds and virtues, which have been less well understood than those of her Jesuit counterparts. The nature of her holy image emerges from a highly selective comparison with the Jesuits’ deeds and virtues as presented in word and image in Rome in March 1622. On the basis of written and visual documents tied to Teresa’s processes and the canonization ceremony, I reinterpret two aspects of her image as promulgated in 1622: the way in which her active and contemplative lives were inextricably linked to her reform of the Carmelite Order; and the role and character of her virtues.

Abstract The year 2003 for Afghanistan was marred by a declining security situation, as resurgent Taliban and other anti-government forces made large sections of the rural areas too dangerous for sustained reconstruction work, and powerful regional warlords continued to defy the attempts of the Kabul government to strengthen statebuilding. Recognizing the danger to its investment there, late in the year, the U.S. altered its military tactics, announced a major new reconstruction grant, and sent a new ambassador. The year ended on a high note, as Afghanistan's Constitutional Loya Jirga promulgated a new Afghan constitution, modeled on the American document, and ratified it early in the New Year on January 4, 2004.

Jahnavi Barua in her 2020 novel Undertow narrates a family sagawhere the relations are estranged due to the daughter’s decision tomarry outside her caste. The novel can be read as the story of threewoman characters– Usha Goswami, Rukmini Goswami and LoyaAlex. These three women are blood relatives; however, they do notshare a common bond of love amongst them. Usha dies withoutaccepting her daughter Rukmini’s marriage; thus, Rukmini’s daughterLoya does not know her grandmother. Rukmini lives an abandonedlife and does not even know about her mother’s death. It is Loya whogoes to her maternal grand parents’ home and claims her mother’splace in it. All the three women seem to follow their own ideologiesand their thoughts and actions provide a suitable set to explore theirposition as a woman. Therefore, the aim of the paper is to explorewhether their decisions are ignited by patriarchy or not and to studythe novel as a feminist text.

7558 Background: Allogeneic hematopoietic stem cell transplantation (allo-SCT) is the only potential curative treatment option for patients with MCL due to its potent graft-versus-lymphoma (GVL) effect. Survival following allo-SCT for MCL is variable due to high rates of non-relapse mortality (NRM). Methods: We retrospectively identified all patients who were treated with an allo-SCT for MCL at Loyola University Medical Center between January 1, 1999 and January 1, 2016. Probability estimates for overall survival (OS) and non-relapse mortality (NRM) at 5 years were calculated from the date of allo-SCT to the date of patient death or last known follow-up. Significance was determined using a cox proportional hazard (CPH) model. Rates of acute graft-versus-host disease (aGVHD) and relapse were also reported. Results: Patient characteristics (n = 29) are listed in Table. Median follow-up in surviving patients is 10 years (range 5-14 years). A majority of patients (n = 23, 79%) had 3 or more lines of treatment prior to allo-SCT. The 5 year rates of OS and NRM for all patients are 42% and 53%, respectively. Univariate analysis showed a lower risk of death in patients who received TBI-based conditioning (HR: 0.19, 95 CI: 0.04 – 0.81, p = 0.03), and those who had HLA-matched related donor (MRD) transplants (HR: 0.29, 95 CI: 0.11 – 0.79, p = 0.02). Patients who received more than 3 lines of prior treatment had a higher risk of death (HR: 2.77, 95% CI: 1.05-7.34, p = 0.04). Low rates of grade III/IV aGVHD (n = 4) and relapse (n = 4) occurred in our patient population. Two patient deaths were attributable to aGVHD, and the majority of other deaths were due to treatment-related toxicities. Conclusions: In an era of numerous effective non-curative salvage therapies, the optimal timing of allo-SCT for MCL needs further clarification. Our data supports early opposed to delayed allo-SCT for select high-risk patients with MCL who have a MRD. [Table: see text]

Abstract Introduction Adolescence is associated with sleep regulatory changes that prompt sleep and circadian timing to shift later (delay). Poor quality, insufficient sleep, and misaligned sleep-wake schedules increase adolescents’ risk for physical and mental health consequences. Little data exists on potential sleep health risks and sleep-wake environments of juvenile justice facilities. This descriptive study examined the sleep-wake environment and daily schedules at juvenile detention and treatment centers in a Mid-Atlantic state. Methods Using our Sleep Justice Observational Checklist, researchers recorded number of windows in sleep and non-sleep areas, and number of beds in sleeping quarters. Illuminance was measured with a light meter during the daytime (standing, sitting, etc.) and averaged. Facility-level 24-hour schedules were obtained to determine youth’s daily routines during the observation period. Results In comparison to treatment centers, detention centers have earlier lights-on (MDet = 6:07 am, SDDet =:40 vs. MTreat = 6:54 am, SDTreat =:07, p = .04) and lights-off (MDet = 8:42 pm, SDDet =:36 vs. MTreat = 9:06 pm, SDTreat =:19, N.S.) times. Treatment center illuminance levels (M = 296.60 lux, SD = 150.30) were greater (brighter) compared to detention centers (M = 124.00 lux, SD = 60.40, p = .01). Per sleep area, treatment centers had more windows (MTreat = 7.84, SDTreat = 6.70 vs. MDet = 1.73, SDDet = .77, p = .02) and more beds (MTreat = 13.30, SDTreat = 14.00 vs. MDet = 1.46, SDDet = .96, p = .03) than detention centers. Conclusion Preliminary results indicate a variation in the sleep-wake environments and daily schedules in this sample of juvenile justice centers. Early lights-on and lights-off times can impose a higher risk for circadian misalignment in adolescents, though schedule consistency may reduce this risk. Ongoing data collection will help to further understand the sleep environment of adolescents in the juvenile justice system. Support Kolvenbach Research Grant, Loyola University Maryland

The Jesuits or ‘The Society of Jesus’ holds a significant place in the wide area of church history. Mark Noll cites John Olin notes that the founding of the Jesuits was ‘the most powerful instrument of Catholic revival and resurgence in this era of religious crisis’.[1] In histories of Europe to the Reformation of the sixteenth century, the Jesuits appear with notable frequency. The Jesuits were the finest expression of the Catholic Reformation shortly after the Protestant reform began. The Society is attributed to its founder, Ignatius of Loyola. As a layman, Ignatius viewed Christendom in his context as a society under siege. It was Christian duty to therefore defend it. The Society was formed at a time that nationalism was growing and papal prestige was falling. As Christopher Hollis observed: ‘Long before the outbreak of the great Reformation there were signs that the unity of the Catholic Christendom was breaking up.’[2] The Jesuits, as a missionary movement at a critical period in the Roman Catholic Church, used creative strategies that later symbolised the strength of what would become the traditional Roman Catholic Church for a long time in history. The strategies involved included, but were not limited to: reviving and nurturing faith among Catholics, winning back those who had become Protestants, converting those who had not been baptised, training of the members for social service and missionary work and also establishing educational institutions.[1] Mark A. Noll. Turning points: Decisive moments in the history of Christianity. (Grand Rapids, Michigan: Baker Books, 1997), 201.[2] Christopher Hollis. The Jesuits: A history. (New York: The Macmillan Company, 1968), 6.

OBJECTIVES/GOALS: University faculty partner with Community Consultants (CC) to: 1) identify health concerns of Chicagos South Side residents, 2) provide information regarding resources that address community health concerns, and 3) disseminate the model across the Institute for Translational Medicines (ITM) institutional partners. METHODS/STUDY POPULATION: CCs met twice monthly with University faculty and staff to identify CGR topics, delivery format, and audience development strategies. Faculty from the University of Chicago and community experts presented on identified health topics. Traditionally held in a community setting, CGR moved to a virtual format due to the pandemic. Recent topics covered included issues around the impact of COVID-19 on African American and LatinX communities and vaccine hesitancy. Audience members were surveyed at the end of each session and provides information on the quality and impact of the content. Twice during the season, partners debriefed on the effectiveness of the partnership and program. A plan was developed to deploy CGR across the ITM partners. RESULTS/ANTICIPATED RESULTS: Since 2010, there have been 63 CGRs, and over 5370 attendees. To date, 95% of audience members report that the content of CGR is of value and would recommend it to others. Audience members surveyed report knowledge gains about the topics presented, satisfaction with venues and speakers, and support the continuation of the series. Despite having to move to a virtual format due to the COVID-19 pandemic, audience members continue to attend CGR and rate the program as valuable and something that they would recommend to others. CCs report commitment to the partnership and CGR. CGR served as a connector for audience members to COVID-19 resources such as grief support groups and financial assistance. Loyola University, an ITM partner, implemented the CGR model, with more planning to do the same. DISCUSSION/SIGNIFICANCE: CGR is effective at providing health information in a community setting. CGRs success is due to the commitment of its partners and its ability to respond to community needs. During the pandemic, attendance at each virtual CGR remained steady and audience feedback remained positive. CGR continues to serve as a connector to valuable resources.

Abstract Introduction: Steroid-refractory grade IV acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (HSCT) carries a mortality rate of approximately 80%. Trials of novel therapies including antibodies directed against the T-cell immune response have generally failed to improve outcomes although may lead to responses. Infliximab, a chimeric monoclonal antibody to TNF alpha, and alemtuzumab another monoclonal antibody targeting CD52, an antigen expressed on T and B lymphocytes and other antigen presenting cells (APCs) both have produced response rates in the 50-75% range. However, few are long-term survivors as the majority die of opportunistic infections (OI). While steroids are ineffective in many series, they are continued when novel agents are employed. We have approached steroid-refractory aGVHD with a combination of rapid steroid discontinuation, standard doses of infliximab and short course low dose alemtuzumab with the hope for aGVHD control without early deaths from OIs. Methods: We identified all patients who were treated for steroid-refractory aGVHD between January 1, 2014 and March 1, 2016 at Loyola University Medical Center. The diagnosis of aGVHD was made by clinical criteria per the National Institutes of Health guidelines. The diagnosis was confirmed by endoscopic evaluation and biopsy of the affected organ. All patients received methylprednisolone 2 mg/kg/day IV given in twice daily dosing for at least 7 days prior to being considered steroid-refractory. Patients received infliximab 10 mg/kg IV infusion weekly x 2 then every other week until remission and alemtuzumab 3 mg IV test dose on day 1, followed by 10 mg IV daily for 4 days. At the same time steroids were reduced by 50% and further reductions of 50% were made every 4 days. Responses were assessed by daily grading of aGVHD per Glucksberg criteria after dosing of infliximab and alemtuzumab. A complete response (CR) was defined as full resolution of abdominal pain, diarrhea, rectal bleeding, liver function test abnormalities, or skin involvement. A partial response (PR) was defined as a 50% improvement in diarrhea, liver function abnormalities, or skin involvement with a decrease in 1 or more grade levels of aGVHD per Glucksberg criteria. Results: To date 6 patients have been treated for steroid-refractory aGVHD after matched related donor (MRD) or matched unrelated donor (MUD) HSCT. Patient characteristics are shown in Table 1. There were 5 patients who underwent a MRD or MUD HSCT for myelodysplastic syndrome (MDS), and 1 patient who underwent a MUD HSCT for B-cell acute lymphoblastic leukemia (B-ALL). Median age at treatment was 64 years. All patients had Glucksberg grade 4 aGVHD (Table 1). The overall response rate (ORR) was 83% with 4 patients achieving a PR, 1 patient achieving CR, and 1 patient with no response to treatment. Day 100 survival after dosing of alemtuzumab was 50% with deaths due to aGVHD in 2 patients and death due to septic shock in 1 patient. CMV reactivation occurred in 4 patients and EBV reactivation occurred in 1 patient. Conclusion: In our single institution analysis, the combination of infliximab and alemtuzumab with rapid steroid withdrawal achieved a high ORR of 83% in treatment of steroid-refractory aGVHD after MRD or MUD HSCT with an encouraging 50% survival at day 100. This approach will be continued to further define its efficacy and safety for the treatment of steroid-refractory aGVHD. Disclosures No relevant conflicts of interest to declare.

Abstract Introduction Limited research exists regarding the sleep environment and sleep health of youth in juvenile justice facilities. We examined the perspectives of facility night staff on the sleep-living environment and conditions of detained youth using semi-structured interviews. Methods In collaboration with Maryland’s Department of Juvenile Services (DJS) we conducted virtual semi-structured interviews (45 minutes) with superintendents, medical staff, and night staff at all state facilities. We present the data reported by night staff (n=10) here, each representing a different facility. Interview questions focused on facility structure, protocols, and youth healthcare. Inductive qualitative analyses examined high frequency themes with the aim of understanding the sleep environment, sleep patterns, and overall youth wellbeing. After transcription of each interview, coder 1 examined each transcript to identify high frequency themes; coder 2 reviewed these first codes. Few disagreements occurred; in those cases, a third coder helped reach consensus. Theme frequency is expressed as a percentage of the total number of transcriptions (e.g., 4 interviews out of 10=40%). Results Major themes reported by night staff include environmental disruptions, ability to personalize sleep areas, youth well-being, and sleep challenges. Environmental disruptions included moderate noise levels (40%); youth temperature complaints (50%); and youth lighting complaints (60%). More specifically, 50% reported youth reported night lighting complaints (including blue light) within the dorms. While 40% described room personalization is allowed, 40% stated it is also limited. For instance, while youth are allowed to display family pictures, they are not allowed to display any gang-related material as it could cause altercations between youth. Complaints of trouble sleeping is addressed in 50% of facilities by utilizing a weeklong sleeping log (e.g., staff report number of times youth are awake during the night during their safety checks). Seventy percent of staff reported that work affects their sleep and psychological wellbeing and 60% shared that they sleep 3 - 6 hours/night. Conclusion Assessment and modifications of the sleep-living environment in juvenile justice facilities are needed. Ongoing countermeasures in the Maryland system include noise buffering panels, light modifications, and sleep-health staff trainings. Support (if any) Kolvenbach grant, Loyola University Maryland and Maryland Department of Juvenile Services’ supportive collaboration.

Abstract Background: Patients with AML-M2 with t (8;21) generally have a good prognosis. However, the subset who have CD56 expression on their leukemic cells have poor prognosis, with frequent extramedullary involvement, short initial remissions, and high mortality. To date, little is known about the outcomes after allogeneic transplantation for patients with these unique characteristics. Methods: The Loyola transplant registry was searched for patients who underwent allogeneic transplantation at Loyola University Chicago Medical Center, Illinois during the period between June, 1998 and May, 2004 with these features. Patients were included in the analysis if their bone marrow examination at presentation met the FAB criteria for AML-M2; t (8;21) (q22;q22) was present by conventional karyotyping or by fluorescence in-situ hybridization (FISH); and CD56 expression was demonstrated by flow cytometric analysis of the leukemic blasts. Results: Five patients were identified; median age was 40 years (range 26–57 years); three were male. Median time from diagnosis until transplant was 12 months (range 3–93 months). Two patients had extramedullary diseases manifested by paraspinal and orbital granulocytic sarcoma at presentation or at relapse. One patient had 9q- in addition to the t (8;21). Patients had received a median of three prior therapy regimens (range 1–10) before transplant, including one patient who underwent high-dose chemotherapy and autologous stem cell transplant. Despite this, 4/5 patients had relapsed or refractory disease at transplant. Preparative regimens were total body irradiation 12Gy plus cyclophosphamide 120mg/kg in four patients and IV busulfan 14mg/kg plus cyclophosphamide 120 mg/kg in one; graft versus host disease (GVHD) prophylaxis was with tacrolimus and methotrexate. Three patients received grafts from matched unrelated donors; the rest from siblings. Three patients received bone marrow ranging from 2.0–4.4 x108/kg WBC and two received peripheral stem cells 4.0–6.07 x106/kg CD34+. The median time to neutrophil engraftment (the first of three consecutive days with absolute neutrophil count above 500/ml) was 14 days (range 12–17). The median time to platelet engraftment (the first of seven days with platelet count above 20,000/ml without transfusion) was 15 days (range 11–29). At day 100, all assessable patients (N=4) were in remission by bone marrow morphology with undetectable t (8;21) by FISH. As of August 2004, three patients survive at a median follow-up of 21 months (range 2–74 months); all remain in complete remission. Grade IV GVHD of skin occurred in one patient and grade II GI GVHD occurred in two. One patient, who received ten chemotherapy regimens over a 93-month period before transplant, died from pneumonia and venoocclusive disease of the liver; the other died from aspergillosis. Conclusions: Long-term disease free survival is possible with allogeneic transplant among patients with AML-M2 with t (8;21) and CD56 expression despite relapsed or refractory diseases. Clinicians should consider allografts, even from unrelated donors, early in the course of the disease to avoid the likely relapses after conventional therapy and to reduce the morbidity and mortality often seen in heavily pre-treated patients.

Abstract Background Clostridioides difficile infection (CDI) is increasingly common among hematopoietic stem cell transplantation (HSCT) recipients and efforts to define CDI risk have shown variable results. The primary objective of this study was to further characterize CDI incidence and risk factors in HSCT recipients. Methods All allogeneic and autologous HSCT recipients at Loyola University Chicago between January 2011 and May 2017 were retrospectively reviewed for development of CDI within 6 months prior to 2 years following HSCT. Collected data include comorbid conditions, statin or proton pump inhibitor (PPI), and antimicrobial use. HSCT baseline information was also obtained and include underlying malignancy, prior chemotherapy, graft type, conditioning regimen consisting of total body irradiation (TBI) use, and donor source (matched related or unrelated and umbilical cord blood). Among those with diagnosed CDI, data pertaining to CDI severity, treatment, and recurrence was collected. Logistic regression analyses were performed to estimate odds ratios for factors associated with development of CDI. Results Six hundred eighty-nine patients met our inclusion criteria. Of these, 367 (53%) underwent autologous HSCT and 322 (47%) allogeneic HSCT. Among all patients, 132 (19.1%) had CDI of which 26 (19.7%) had recurrence within 60 days. In univariable analysis, any type of leukemia was associated with increased odds of CDI compared with lymphoma (OR = 2.44, 95% CI: 1.49- 4.00, P < 0.01) as was allogeneic HSCT compared with autologous (OR = 2.51, 95% CI: 1.63–3.88, P < 0.01 for matched and OR = 3.96, 95% CI: 2.31–6.79, P < 0.01 for cord blood) and use of TBI (OR = 1.63, 95% CI: 1.10 – 2.40, P < 0.05). Exposure to any cephalosporin or intravenous vancomycin within 100 days of HSCT was associated with CDI (OR = 1.55, 95% CI: 1.03–2.32, P < 0.05 and OR = 1.75, 95% CI: 1.19–2.58, P < 0.01 respectively). No significant differences in the odds of developing CDI were identified by patient comorbidities, statin or PPI use. Conclusion In our population there was a 19% incidence of CDI. Underlying leukemia, TBI exposure, and allogeneic HSCT appear to be risk factors for CDI and further research is needed to evaluate whether exposure to cephalosporin or vancomycin may be modifiable risk factors. Disclosures All authors: No reported disclosures.

Abstract Abstract 3070 Life-threatening cardiac events following allogeneic bone marrow transplants (BMT) are not uncommon at 5–12.5% of patients. While BMT programs perform screening EKGs and ejection fraction measurements, solid organ transplant centers follow a risk stratification screening algorithm to assess for coronary artery disease (CAD) which includes stress tests and as indicated, angiography in those with 2 or more risk factors. It is currently unknown whether this algorithm should be applied in the BMT setting. Methods: We performed a retrospective review of 296 patients who underwent allogeneic BMT at Loyola University Medical Center 2007–2011, to assess cardiac events using the solid organ transplant advanced screening criteria: age over 60 or over 40 with peripheral vascular disease or diabetes and then divided patients into low risk (one CV risk factor) and high risk groups (greater than one CV risk factor). Risk factors included age, hypertension, diabetes, smoking, family history of CAD, and obesity according to the Framingham risk assessment score for CAD. Cardiac events during the first year post-transplant were recorded including CHF, myocardial infarction (MI), and symptomatic arrhythmias. One hundred day and 1-year Kaplan-Meier survival for high and low risk patients were determined and curves compared by log-rank tests. A multivariate analysis of the various prognostic factors was performed using the Cox regression model. Results: Of the 296 total allografts, 116 patients (39%) fit the solid organ transplant criteria for advanced screening; 62% were male (n = 72) and the mean age was 60.6 (range 40–72). Graft source was evenly distributed between siblings (42%), unrelated (39%) and cord blood (28%). Acute myeloid leukemia was the most common indication for BMT at 40%, followed by MDS (21%), non-Hodgkin lymphoma (16%), and CLL (10%). Of the 116, 21 were considered low risk (1 risk factor), while 95 were high risk (2+ risk factors). Low risk and high risk groups did not differ in disease type (p = 0.43), graft source (p = 0.81), or graft type (p = 0.54). Surprisingly, both high and low risk patients had a similar incidence of cardiac events of 36% and 48%, respectively. This correlated to comparable 100-day and 1 year survival rates. To determine the importance of cardiac complications on outcome and whether there were other risk factors for complications we analyzed those with a complication. Forty-four cardiac events occurred in the first year after transplant in 38 (33%) patients. Cardiac events included arrhythmias (n = 33), new onset CHF (n = 6), and MI (n = 5). Median time to event was 16 days post-transplant. Symptomatic arrhythmias included atrial fibrillation (n = 27, 82%), supraventricular tachycardia (n = 5, 15%) and sustained ventricular tachycardia (n =1, 3%). Median age for patients with cardiac events was 62.7 years, compared to 59.6 for patients who experienced no cardiac events (hazard ratio estimate: 1.076; p = 0.02). As compared to patients with no post-transplant cardiac events, both the 100 day and 1 year survival rates of patients with cardiac events were lower with one year survival of 21% vs. 63% (p < 0.0001). Evaluating risk factors, 3 were significant: donor source with MUD donors the highest hazard (p = 0.04); age, with cardiac events occurring at a rate twice as high in patients greater than age 60 (n = 27, 36.5% vs. n = 6, 19.4%), and with all five cases of myocardial infarction and 5/6 new CHF diagnoses occurring in patients aged 60 or greater; and patients with a history of atrial fibrillation demonstrated a higher probability of developing a cardiac event post-transplant (p = 0.02). Conclusions: In this analysis, we saw a much higher incidence of post-BMT cardiac events (33%) than previously reported, although we focused only on at risk patients using the solid organ screening algorithm (pts > 40 with significant risk factors or all pts > 60). As mortality rates at 100 day and 1 year are higher for patients who suffer a post-BMT cardiac event, and only graft source, age and prior atrial fibrillation marked patients at a very high risk, this data indicates that it is appropriate to investigate prospectively the solid organ transplant algorithm in all allogeneic BMT patients > age 40, with low cardiac risk or any patient > 60 with stress tests and as indicated, cardiac catheterization. Whether this will decrease events and thereby improve survival remains to be determined by prospective studies. Disclosures: No relevant conflicts of interest to declare.

e19058 Background: HSCT remains the only curative treatment for high-risk hematologic malignancies. Reduced intensity conditioning (RIC) has increasingly allowed transplant of elderly patients. However, maximizing outcomes in this population remains a challenge. We examine the influence of BMI and weight changes on HSCT outcomes in the elderly. Methods: This was a retrospective review of 216 patients ≥60 years of age who underwent first HSCT at the Loyola University Medical Center between 8/30/2000-6/15/2017. Pearson Chi-square tests for independence evaluated the associations between categorical variables and timing of recurrence. Fisher’s exact test were used where expected frequencies were <5. Independent two-sample t-tests and ANOVA assessed differences in numerical variables. Results: BMI at time of transplant, defined as underweight (BMI<18), normal weight (BMI 18-25), overweight (BMI 25-30), and morbidly obese (BMI>30), did not impact incidence of cardiac dysfunction, pulmonary complications (Cx’s), renal Cx’s, graft versus host disease (GVHD), paraenteral nutrition (TPN) use, changes in albumin, or mortality. However, there was a trend towards increased disease relapse in those who were not normal weight (p=.08). Normal weight (BMI 18-25) at Day 100 was associated with decreased cardiac dysfunction (p=.02), days of hospitalization (p = .03), and mortality (p = .02) compared to non-normal BMI (BMI < 18 or BMI > 25). But there appeared no difference in rates of renal Cx's, GVHD, TPN use, or relapse. Having >10% weight change at discharge from transplant admission was associated with increased renal Cx’s (p = .007), infectious Cx’s (p = .03), use of TPN (p = .006), length of hospital stay (p = .0002), and mortality (p = .009). However, it was not associated with cardiac dysfunction, pulmonary Cx’s, readmissions by 6 months, GVHD, or relapse. Having >10% weight change at Day 100 was associated with increased risk of acute (p = .01) and chronic GVHD (p = .002) and readmissions by 6 months (p = .01), but not with other Cx’s, relapse, or mortality. Conclusions: Patients who were underweight or overweight at key timepoints may impact complications and HSCT outcomes. Furthermore, maintaining a stable weight during transplant admission and the first 100 days was associated with decreased rates of complications and adverse HSCT outcomes. These findings warrant further evaluation into age-related weight and nutritional targets to improve understanding and optimize HSCT outcomes in this vulnerable population. [Table: see text]

Abstract Introduction: Acute graft-versus-host disease (aGVHD) is a leading cause of transplant related mortality following allogeneic hematopoietic stem cell transplantation (HCT). The most widely used aGVHD prophylaxis regimen is a combination of a calcineurin inhibitor and a short course of methotrexate. Results of studies on the optimal blood levels of the calcineurin inhibitor tacrolimus to prevent aGVHD are mixed, with some showing no correlation and others indicating that trough levels between 7-15 ng/mL required to adequately prevent aGVHD. Currently, the established target trough level for this agent is 10 to 20 ng/mL. We retrospectively evaluated the relationship between tacrolimus blood concentration and the incidence of grade II-IV aGVHD in a large cohort of adult patients following allogeneic HCT from either an HLA-matched related or matched unrelated donors. Methods: We evaluated all related/unrelated allografts between January 2004 and December 2012 at the Cardinal Bernardin Cancer Center at Loyola University. Inclusion criteria included age 18 years or older, first allogeneic HCT for a hematological malignancy, and use of tacrolimus and short term methotrexate for aGVHD prophylaxis. Donors included human leukocyte antigen (HLA) identical sibling (Allo-Sib) or unrelated donors (MUD) either fully matched or 1 antigen mismatched (10%). Both myeloablative and non-myeloablative conditioning regimens were included. Disease risk was defined by the ASBMT classification and Co-Morbidity Index by Sorror et al (HCT-CI). Infusional tacrolimus was initiated on day -2 of HCT at dose of 0.03 mg/kg/d and AM trough blood concentrations measured every other day during the entire hospital stay with the goal of maintaining a level of 10-15 ng/ml and then twice weekly after discharge. Dose adjustments or withholds were based primary on serum creatinine and trough levels per a set protocol that withholds for levels greater than 20 ng/ml or creatinine greater than 2.0 mg/dl. Acute GVHD was graded based on the International Bone Marrow Transplant Registry System. Univariate and multivariate analyses exploring all risk factors for aGVHD were performed. Results: A total of 428 patients met the inclusion criteria. Median age was 48.5 years with a male predominance (60.6%). HCT-CI was evenly distributed with 121 (28.2%) low risk, 151 (35.3%) intermediate risk, and 156 (36.4%) high risk. Per ASBMT disease risk classification, more patients had high disease risk (n=211, 49.3%); 64 (15%) with intermediate risk, and 153 (35.7%) with low risk. Acute GVHD II-IV developed in 186 (43%) patients in this largely myeloablative patient population (89%), with donor source split nearly evenly between MUD (45%) and Allo-sib (55%). An extensive univariate analysis for the factors associated with the development of aGVHD was developed (Table 1). The strongest predictor of aGVHD was a level of tacrolimus < 5 ng/ml in weeks 3 and 4 after transplant: of those with no aGVHD only 16.9% had a level < 5 ng/ml during these weeks vs 27.4% with aGVHD (p = .009). Other tacrolimus trough cut points, i.e. 10 ng/ml, 2.5 ng/ml and the mean (13.4 ng/ml in each group) were not associated with a higher rate of aGVHD. In the univariate analysis, AML and allo-sib grafts were noted to be associated with lower risk of aGVHD. In multivariate analysis (Table 2), tacrolimus levels less than 5 ng/ml in weeks 3 or 4 was found to be the most statistically significant factor in predicting aGVHD incidence (Odds ratio 82 95% CI 1.13-2.94; p = .01); other significant factors include HCT-CI (p = .02) and graft source (p = .04). Conclusion: In one of the largest retrospective studies examining the correlation of early tacrolimus blood concentrations and acute GHVD incidence, we show that trough tacrolimus levels less than 5 ng/ml in weeks 3-4 following Allo-Sib or MUD HCT is a strong predictor for an increased risk of aGVHD. We affirm that higher HCT-CI and donor source are risk factors for aGVHD after allografts. This not only helps define more accurately the lower limits of acceptable tacrolimus levels, but appears to emphasize the importance for close monitoring and dose adjustment of these levels at a time when patients are typically discharged to the outpatient setting. Disclosures No relevant conflicts of interest to declare.

Abstract Introduction Non-Hodgkin’s Lymphoma (NHL) is the most common hematologic malignancy in the United States with 69,700 new cases and 19,000 deaths predicted in 2013. The majority of patients diagnosed with NHL respond well to conventional chemotherapy, however, patients with relapsed or refractory NHL usually have poor long-term outcomes. While autologous stem cell transplantation (auto-SCT) is a mainstay for patients with relapsed or refractory disease that are chemotherapy-sensitive, allogeneic stem cell transplantation (allo-SCT) has been used to treat NHL in patients who have relapsed after auto-SCT, are chemotherapy-resistant, or have adverse risk factors. While some evidence has suggested that chemotherapy-resistant disease status prior to allo-SCT is associated with a poor prognosis, limited data exists to guide evidence-based transplant paradigms. We sought to determine if disease status prior to allo-SCT in patients with relapsed or refractory NHL impacts outcomes. Methods A retrospective chart review identified 154 patients diagnosed with relapsed or refractory NHL who underwent an allo-SCT at Loyola University Medical Center between January 1998 and January 2012. Fifteen patients were excluded for lack of data yielding 139 patients over a 14-year period. Of our patients with relapsed or refractory disease, chemotherapy-sensitive patients were defined as patients with partial or complete response to chemotherapy at time of transplant. Chemotherapy-resistant patients were defined as patients that either had progressive disease or were refractory to chemotherapy at time of transplant. Data on age, sex, type of NHL, stage at diagnosis, chemotherapy regiment, previous auto-SCT, disease status prior to allo-SCT, overall survival, and cause of death were collected. Results Of the 139 patients, the median age was 48 years with a male to female ratio of 1.4:1. The majority of patients had stage 3 or 4 disease (74%). Breakdown of NHL subtype revealed 31% diffuse large B-cell (DLBCL), 31% follicular, 13.7% mantle cell, 8% T-cell, 3.6% Burkitt’s, 2.1% marginal cell, and 10.7% other category that included small lymphocytic, anaplastic, natural killer cell, mixed cellularity, and unspecified NHL. A total of 44 patients (31%) underwent auto-SCT prior to allo-SCT. Subtypes of allo-SCT included matched sibling (45.3%), matched unrelated donor (MUD, 39.6%), and cord blood transplant (15.1%). Matched sibling allo-SCT had an improved 2 year overall survival of 57.1% when compared to MUD and cord allo-SCT (33% and 30%, respectively). Overall survival after allo-SCT for all patients was 41% at 3 years and 33.1% at 5 years. Disease status prior to transplant was divided into two categories: (1) chemotherapy-resistant (97 patients, 69.7%) and (2) chemotherapy-sensitive (42 patients, 30.2%). There was no statistical difference in overall survival between the chemotherapy-resistant and chemotherapy-sensitive groups at 6 months (60.8% and 78.5% respectively, p=0.066) and at 3 years (40.2% and 42.8% respectively, p=0.91). In a subgroup analysis, DLBCL patients with chemotherapy-resistant disease had similar 3 year survival as compared to patients with chemotherapy-sensitive disease (22.2% and 23%, respectively, p=0.93). Similar results were observed for both subgroups of patients with follicular lymphoma, with 55.2% survival in the chemotherapy-resistant group as compared to 64.2% in the chemotherapy-sensitive group at 3 years (p=0.81). Conclusion Our data suggest that disease status at the time of transplant does not impact survival outcomes in patients with relapsed or refractory NHL. This finding extended into a sub-group analysis of DLBCL, representative of an aggressive NHL subtype, and follicular cell lymphoma, representative of an indolent NHL subtype. We hypothesize that the comparable survival outcomes between chemotherapy-sensitive and chemotherapy-resistant disease states at transplant may be a result of graft versus lymphoma effect and use of a disease free graft. As no survival advantage was incurred in patients with chemotherapy sensitive disease, these data imply that the lymphoma burden at time of transplant is not prognostic. This potentially highlights the utility of earlier time to transplant in patients with chemotherapy-resistant disease, and perhaps suggest limiting the duration of attempted salvage chemotherapy after disease relapse. Disclosures: No relevant conflicts of interest to declare.

The history of travel is becoming increasingly attractive to cultural historians. Although the number of studies is growing, insufficient attention has so far been paid to travel writings within particular social groups. The aim of the paper is to present insufficiently researched examples of eighteenth-century travel writings by Lithuanian Jesuits, in which they relate of their journeys in Western Europe, and to discuss them against the overall context of travel writing of the Grand Duchy of Lithuania in the Age of Enlightenment. With his aim in mind, in this paper the author compares travel journals of different epochs, social strata, and sexes, assuming that Jesuit travel diaries might reflect the influence of the Jesuitic social status and education on the objects visited and on the prevailing narratives of travel writing.The study is based on the descriptions of three journeys of eighteenth-century Jesuits: the travel journal of Adalbert Bohuszewicz, rector of the Jesuit College of Polotsk, about his journey to Rome and back, a description of European travel by the former Jesuit Franciszek Ksawery Bohusz, and a travel guide to Rome by the former Jesuit Kazimierz Kognowicki. These travel diaries by eighteenth-century Lithuanian Jesuits follow the common trends of travel writing of their time: they display the presence of critical thinking and evaluation as well as a changed relation between the author and the ostensible reader. Although the aims of the three texts differ, it is evident that the authors made efforts not only to preserve information but also to stir the interest of the future travellers.Since urban secular and sacral spaces are often separated in travel descriptions, the article accentuates the descriptions of these spaces and possible shifts in them. The author of the paper expands on the descriptions of the urban space as it is there that the changes of the epoch can best be felt. The descriptions of cities become somewhat more cautious and critical. The examined travel writings show that their authors were acquainted with the latest literature and were aware of travel trends, as demonstrated by their visits to newly-discovered archaeological sites in Rome and southern Italy. The impact of the epochs is best seen in the descriptions of sacral buildings. The travel journals of the eighteenth century no longer contain vivid stories of martyrdom, which flourished and were very descriptive in the travel diaries of the Baroque period.The investigation shows that compared to travel writings by the laity and the representatives of other monastic orders, the travel diaries of the Jesuits tend to focus on ‘Jesuit’ objects: descriptions of colleges and sacral buildings. More emphasis is given to the personalities of Ignatius of Loyola and Stanislaus Kostka. However, speaking in general, the examined sources more reflect the period’s established traditions of travel writing than manifestations of the collective identity of a social group.

Abstract Background: The SWOG 9011 trial of augmented conditioning regimens (12 Gy TBI or BCNU 15mg/kg with both etoposide 60 mg/kg and cyclophosphamide 100 mg/kg) prior to single AHCT for pts with relapsed or refractory HL demonstrated 5-yr PFS and OS of 41% and 54% respectively in 74 treated pts. Among 46 previously irradiated pts with 2-3 high risk features, the 5-yr OS was 38% compared with 60% for pts with 0-1 risk features. Post-AHCT relapse was the major cause of failure (Stiff et al. BBMT 2003; 9:529). The strategy of sequential high-dose (HD) chemotherapy + tandem AHCT for poor prognosis HL patients was investigated in a City of Hope (COH) & Loyola University (LU) pilot trial of tandem AHCT in 46 HL pts with primary progressive or relapsed HL with at least 1 poor-risk feature. Trial results were promising, with 5-yr OS, EFS and FFP of 54%, 49% and 55% respectively and 100-day TRM of 4% (Fung et al. BBMT 2007;13:594). The purpose of the SWOG led trial S0410 was to evaluate the COH/LU regimen in a phase II cooperative group setting, with the primary endpoint of 2-yr PFS. Methods: Pts with refractory/relapsed HL, eligible ages 15 -70, were enrolled after salvage therapy & stem cell collection (minimum 3.5 X 10.6 CD34/kg). Pts with relapse after prior CR received minimum of 2 cycles salvage chemotherapy or minimum of 25 Gy involved field radiation therapy (IFRT) to determine if they had sensitive or resistant HL. Pts with late relapse (> 12 months after 1st CR) responsive to salvage therapy were excluded. Pts with > 5cm bulk disease after salvage had to agree to 18 Gy IFRT pre-AHCT. A designed sample size of 85 pts over 2-yrs with 18 months follow-up was chosen to have 86% power by 0.025 one-sided alpha test to detect a 15% increase in 2-yr PFS as compared to the historical 2-yr PFS of 45% in S9011. After IFRT to bulk disease pre-AHCT, pts were treated with cycle 1 HD-Melphalan (150 mg/m2) + AHCT. If response after cycle 1 AHCT was SD or better, pts had 2nd AHCT with one of the two HD regimens used in SWOG 9011. Interval between day zero of 1st and 2nd AHCT had to be at least 28 days & not greater than 60 days. Results: 98 patients enrolled from 10 institutions including the BMT CTN. Six ineligible pts had inadequate PFTs (1), incomplete baseline testing (3) or failure to confirm pathology by central review (2). Median age was 34 yrs (range 18-60), 45% had refractory disease, 42% had B symptoms, and 24% had extranodal disease at transplant. Of the 92 eligible pts, 89 were treated, 82 completed both cycles of AHCT and 7 pts did not have 2nd AHCT (1 progressed, 1 declined TBI, 4 with > 60 days since 1st AHCT, 1 poor graft after C1.) Of 89 pts assessed for toxicities, 70 had grade 4 AEs, primarily hematologic and 14 of those pts had grade 4 non-hematologic AEs. Treatment-related mortality was 0%. With median follow-up of 5.4 yrs (range 2 -7.6 yrs), the 2-yr PFS was 63% (95% CI: 52%, 72%) and 2-yr OS was 91% (95% CI 83, 95%), as shown in figures 1 and 2 respectively. There were 15 deaths in eligible pts, 2 deaths in ineligible pts, and 3 deaths in inevaluable pts who did not receive protocol therapy. Of the 15 deaths in eligible and evaluable patients, there were 11 deaths due to progressive HL, 1 death due to non-treatment related respiratory failure, 1 death due to disseminated CMV infection and 2 deaths with primary cause not reported. Late malignancies were mylelodysplasia in 2 pts, thyroid cancer in 1 pt, and 2 pts with non-melanoma skin cancer. Conclusions: The 2-yr PFS of 63% in pts treated with tandem AHCT on S0410 met the predicted study endpoint of at least 15% improvement compared with the 2-yr PFS of 45% in the S9011 trial of augmented HCT conditioning prior to single AHCT. The better-than-expected OS of 91% in S0410 is attributed to the current treatment strategies for progressive or relapsed HL after AHCT, including brentuximab vedotin (BV) salvage and allogeneic HCT, which can lead to a significant percentage of long term survivors. Analysis of prognostic features will be conducted to ascertain if a model can be developed to identify a very high-risk group of HL pts who should be considered for early allogeneic HCT. Next steps will need to take into consideration results of the recently completed trial of BV consolidation after single AHCT; however, the S0410 results are very promising considering the patients had poor-risk relapsed and refractory HL. Support: CA32102, CA38926 Figure 1 Figure 1. Figure 2 Figure 2. Disclosures Fisher: Johnson & Johnson : Consultancy; MorphoSys AG: Consultancy.

READING GENESIS WELL: Navigating History, Poetry, Science, and Truth in Genesis 1-11 by C. John Collins. Grand Rapids, MI: Zondervan Academic, 2018. 336 pages. Paperback; $36.99. ISBN: 9780310598572. *C. John Collins makes judicious use of C. S. Lewis throughout his book and offers a reading of the early chapters of Genesis that seeks to avoid both an ahistorical fundamentalist interpretation and a dismissive scientism that views Genesis as bad science by ignorant people. Collins identifies himself as a "religious traditionalist," and he seeks to read Genesis in ways that take seriously the original context of the author and first readers of the text. In doing so, he makes more evident the real meaning of Genesis as a rival creation story to other creation stories circulating at that time in the ancient near East. Collins has a twofold goal. "The first is to provide guidance to those who want to consider how these Bible passages relate to the findings of the sciences. The second is to establish patterns of good theological reading, patterns applicable to other texts" (p. 32). *Collins emphasizes quite rightly that to interpret a text correctly it is important to consider the context. It is context that determines whether the words, "I'm going to kill you" are a lethal threat to life or the joking retort of a friend. Genesis is not trying to do contemporary science, so to read Genesis as opposed to or in support of contemporary science is to rip Genesis from its ancient context in terms of both its literary form and its world view. The story of Genesis is not trying and failing to answer contemporary scientific questions; rather, the story of Genesis is emphasizing that, "all human beings have a common origin, a common predicament, and a common need to know God and have God's image restored in them" (p. 113). *We can understand what Genesis truly means by putting Genesis back into its ancient context. As Collins notes, "I take the purpose of Genesis to begin with opposing the origin stories of other ancient peoples by telling of one true God who made heaven and earth ..." (p. 137). Once Genesis is put back into its context, we can better appreciate the genre of the work. The language of Genesis is not scientific but poetic. Collins notes that we can communicate truths using different kinds of language. In ordinary language, we say, "You are beautiful." In scientific language, we might say, "You exhibit visible signs of youth, health, fertility, and symmetry." In poetic language, we could say, "Shall I compare thee to a summer's day? Thou art more lovely and more temperate: Rough winds do shake the darling buds of May, And summer's lease hath all too short a date." Imagine someone who got out a weather almanac, looked up the speed of winds last May, and replied, "Last May, the winds were unseasonably calm. No rough winds at all. Shakespeare was horrible at correctly noting the weather! What a dunce!" Of course, in writing Sonnet 18, Shakespeare was not trying and failing to compose an accurate weather report. The Bard's purposes, genre, and context are entirely different than meteorology. So, too, Genesis is not trying and failing to provide a scientific account of the origin of sun, moon, and stars--or man. To fault Genesis as a bad science is like faulting Shakespeare as a bad weather man. Collins correctly notes, "To call Genesis 'science,' whether ancient or modern is an enormous literary confusion" (p. 279). *So, if Genesis is not failing to be good science, since it is not even attempting to do science, what is Genesis about? The Genesis account is a correction to the rival stories of the ancient world. Genesis holds, in contrast to the pagan myths, that the sun, moon, and stars are not gods. The heavenly bodies exist to serve humans, to mark time. The idea that nature is not a god is an idea of signal importance, for if the created order is not divine, then the door is open for science to dissect and examine the secrets of nature. Genesis steers a middle course between a radical environmentalism (worshiping nature as divine) and a radical anti-environmentalism (domineering of nature as worthless material). *The role of humankind is also made more plain by contrasting Genesis with rival stories. Collins notes, "In the Mesopotamian stories the gods made humankind to do the work they do not wish to do, but they regret their action and decide to eliminate humanity because people have multiplied and become so noisy that the gods cannot rest (which was their original goal in making man)" (p. 190). *How unlike the God of Abraham who urges human beings to be fruitful and multiply. The Greek poet Hesiod wrote, "Zeus who thunders on high made women to be an evil to mortal men, with a nurture to do evil." By contrast, Genesis proclaims both man and woman to be made in the image and likeness of God. Both man and woman fall to the serpent's temptation. Both man and woman are cared for by God after the Fall. *Reading Genesis Well is a good book, and it could be made even better. At times, there is a great deal of windup before the pitch. At other times, there is needless repetition. For example, Collins writes, "The creation narrative portrays the sun, moon, and stars as makers for the (liturgical) seasons. They are servants to help humankind worship the Maker, not masters themselves worthy of human worship" (p. 293). This is a great point, but the point is made at least three times in the text. *The organization of the text could be improved in places. For example, when Collins quotes Rudolf Bultmann's famous assertion, "It is impossible to use the electric light and the wireless [radio] and to avail ourselves of modern medical and surgical discoveries, and at the same time to believe in the New Testament world of spirits and miracles," he does not respond to this assertion until pages later. *In places, not just form but substance can be improved. Collins quotes with approval James Packer saying, "The church no more created the canon [of scripture] than Newton created the law of gravity; recognition is not creation." But this is not quite right. The New Testament was written by early leaders of the church, such as Paul, Mark, Luke, Matthew, and John. It was the Council of Rome (p. 382) that fixed the biblical canon which was in some state of flux until then. The New Testament arose from the leaders of the early church and was cast into its current form by the leaders of the patristic church. That is much more than a mere recognition. Collins touches on the monogensism-polygenism question but does not address the dispute at sufficient length. *None of these quibbles should deter readers from profiting from Collins's research. Reading Genesis Well can indeed help us better understand one of the most ancient, most important, and most influential texts of all time. *Reviewed by Christopher Kaczor, Professor of Philosophy, Loyola Marymount University, 1 LMU Drive, Los Angeles, CA 90045.

NAVIGATING FAITH AND SCIENCE by Joseph Vukov. Grand Rapids, MI: Eerdmans, 2022. 179 pages. Paperback; $19.99. ISBN: 9780802879615. *Joseph Vukov, Assistant Professor of Philosophy at Loyola University Chicago, takes on the relationship between sciences and Christian faith in his engaging book Navigating Faith and Science. Written for a popular audience, Vukov discusses three models for the sciences-faith relationship: conflict, independence, and dialogue. *Ongoing conversation always takes place in the context of a relationship, and I like to think of the sciences-faith relationship as such an ongoing conversation. Conversation in any relationship can be challenging. Similarly for the sciences-faith relationship. Human conversations are dynamic, full of surprising twists and turns, frustrations, joys, and pains. Similarly for conversations among sciences and faith. *Intellectual arrogance negatively affects sciences-faith conversations. Vukov's helpful starting point in chapter 1 frames intellectual humility as crucial to navigating the sciences-faith relationship. He argues that intellectual humility involves "a cognitive aspect (accurate self-assessment), an emotional aspect (not being caught up in one's own desire to be right), and most importantly, a purposeful aspect (aiming at the truth)" (p. 15). Vukov has insightful things to say about intellectual humility as a human virtue reflecting appropriate appraisal (Rom. 12:3) of our finitude. He rightly points out that a confident faithful Christian "is not intellectually arrogant," but trusts deeply in God's promises and wisdom (p. 25). How does this help with the sciences-faith relationship? Practicing intellectual humility avoids intellectual arrogance in the sciences-faith relationship. *Vukov discusses conflict in chapter 2, following Ian Barbour in christening a conflict model for the sciences-faith relationship. While Vukov identifies intellectual arrogance as an important source of conflict, this does not explain why conflicts arise. Conflict is possible only on concordance models for the relationship. A concordance model presupposes that along with whatever principles of biblical interpretation we adopt, we also demand that there necessarily must be a correspondence or implication between scientific and faith statements. Think of a jigsaw puzzle, in which scientific and faith statements contribute pieces to the puzzle but also function as constraints for what can fit into the puzzle. *For instance, modern young-Earth creationism presupposes that the statements of Genesis 1 constrain or correct any scientific statements about the age of the earth. In contrast, day-age interpretations presuppose a correlation between the days of Genesis 1 and geological ages. When one reads Genesis 1, assuming that its statements necessarily have correspondence to or implications for scientific statements, conflicts between the sciences and faith arise. The above statement explains why conflict models are concordance models. Concordance models almost always pitch a battle between taking sciences or faith as primary in setting the constraints on what goes into the puzzle. But this is a false forced choice. The concordance assumption demands we choose between what God reveals to us through the detailed study of his good creation and what God reveals to us through the study of scripture. *Vukov claims, "According to the Conflict Model, science and religion compete to answer the questions we have about ourselves and the world around us ... science and religion are (more or less) playing the same game" (p. 32). Although he never discusses it, this is the concordance assumption: there is only one puzzle, sciences and faith can contribute pieces to the puzzle, but only one of them can constrain what pieces are acceptable. Every example of conflict Vukov gives turns on interpretation of biblical texts and scientific research and the assumption of necessary concordance between the two. *Note that conflict is a form of relationship and a form of conversation. As the concordance assumption highlights, conflict conversations often take the form of "Our dialogue has to be on my terms, not yours!" or the incessant repetition of "Well, what about this piece of the puzzle ...?" Are these productive relationships or good conversations carried out well among conversation partners? No. *Vukov is right that embracing intellectual humility leads to recognizing that all relationships involve incomplete, limited knowledge. In this context, conversation partners are not always open to hearing what the other has to say because they underestimate how incomplete their own knowledge is. Intellectual arrogance leads to stunted conversation: one partner assumes that faith is the best authority on all questions about the natural world while the other assumes the sciences are. As Vukov notes, both parties insist their approach is "right at all costs," and end up undermining "the pursuit of truth that guides both religion and science" (p. 51). Yet, this only happens because of the concordance assumption. *Maybe the best way to approach the sciences-faith relationship is dropping the concordance assumption. But there are better and worse ways of doing this. An example of the latter is the independence model (chap. 3), in which sciences and faith are separate, nonoverlapping domains. Independence models assume that sciences and faith contribute pieces to separate puzzles. *While Vukov's discussion of independence is helpful and engaging, to think that this model is not a form of sciences-faith conversation is too quick. Think of two people saying they will not talk due to irrelevance, lack of interest, or not seeing the point. Indeed, advocates of independence models cannot stop themselves from reiterating that there is no intersection, no relevance to any ongoing conversation between sciences and faith. Often, such advocates will repeat to each other they are both better off having no substantial conversation, repeating their reasons why (e.g., Michael Ruse). *A third way for understanding sciences-faith relationship is allowing that sometimes scientific and religious statements have an overlap. Nevertheless, we never force these connections; instead, we let them arise organically as we continue the work of exploring nature and plumbing the depths of faith. What do we do when overlap is found? We talk it through, hashing out the nature of the overlap and its meanings. This is Vukov's dialogue model (chap. 4). His emphasis on intellectual humility as a Christian virtue pays off most in this chapter because genuine conversation, in which we honestly seek to learn from each other and build relationship, is hard work! But it is necessary work if we are to honor Christ in the sciences-faith relationship aiming to exhibit how everything coheres in Christ (Col. 1:17). It is much easier to invoke the hubris of "I'm right; you have to agree with me"--concordance; or to tell each other, "Look, we're better off if we stay out of each other's hair"--independence. *These latter approaches assume that the sciences-faith relationship is fixed and settled once for all. Yet, like any human relationship, the sciences-faith relationship is always ongoing and dynamic, involving navigation and renegotiation. Try treating your relationship with your spouse or best friend as fixed and unchanging and see where that leads! The sciences-faith relationship cannot be healthy and growing unless we take the multiple perspectives involved seriously, as contributors to the ongoing conversation of how to do life together. PSCF readers interested in pursuing that adventure will be rewarded by a close reading of chapter 4 and its examples. *In chapter 5, Vukov attempts to show that we need the conflict, independence, and dialogue models to do different jobs at different times. But this leads to an incoherence in his discussion. I think taking the ideas of relationship and conversation more seriously could remedy the incoherence. For instance, Vukov critiques the dialogue model by pointing out that some proponents only have dialogue as a goal. But this is a failure to grasp that the sciences-faith conversation is always in service of learning more about each other and growing in how to get along as partners coming to understand God's world. In a marriage, little gets accomplished if partners simply focus on dialogue for the sake of dialogue. Likewise, little gets accomplished if partners engage in conflict or independence. Understanding the relationship, when we can mutually help each other, when it is appropriate to encourage the other to "do your thing!," and how to productively engage those times when we find ourselves in a conflict are all part of working out healthy ongoing relationship. Similarly for the sciences-faith relationship. *If sciences and faith are aiming at truth, as Vukov correctly argues, then the focus should be on developing the healthiest relationship enabling sciences and faith to pursue that aim. Arguing that the relationship is best modeled sometimes as conflict, sometimes as independence, or sometimes as dialogue, undercuts the aim for truth. A marriage or a family would not work well if partners are constantly shifting their relationships among these options. Instead, one always needs to understand how conflicts arise and how to address them within the ongoing relationship of a marriage. One always needs to understand what appropriate forms of independence are in the ongoing relationship of the family. And these understandings always need to take place in the context of humble, open conversation. *Good dialogue is central to any healthy human relationship. The same is true for the sciences-faith relationship. *Reviewed by Robert C. Bishop, Department of Physics and Engineering, Wheaton College, Wheaton, IL 60187.

A gene regulatory network (GRN) consists of genes, transcription factors, and the regulatory connections between them that govern the level of expression of mRNA and proteins from those genes. Our group has developed a MATLAB software package, called GRNmap, that uses ordinary differential equations to model the dynamics of medium‐scale GRNs. The program uses a penalized least squares approach (Dahlquist et al. 2015, DOI: 10.1007/s11538‐015‐0092‐6) to estimate production rates, expression thresholds, and regulatory weights for each transcription factor in the network based on gene expression data, and then performs a forward simulation of the dynamics of the network. GRNmap has options for using a sigmoidal or Michaelis‐Menten production function. Parameters for a series of related networks, ranging in size from 15 to 35 genes, were optimized against DNA microarray data measuring the transcriptional response to cold shock in wild type and five strains individually deleted for the transcription factors, Cin5, Gln3, Hap4, Hmo1, Zap1, of budding yeast, Saccharomyces cerevisiae BY4741. Model predictions fit the experimental data well, within the 95% confidence interval. Open source code and a compiled executable that can run without a MATLAB license are available from <http://kdahlquist.github.io/GRNmap/>. GRNsight is an open source web application for visualizing such models of gene regulatory networks. GRNsight accepts GRNmap‐ or user‐generated spreadsheets containing an adjacency matrix representation of the GRN and automatically lays out the graph of the GRN model. The application colors the edges and adjusts their thicknesses based on the sign (activation or repression) and the strength (magnitude) of the regulatory relationship, respectively. Users can then modify the graph to define the best visual layout for the network. The GRNsight open source code and application are available from <http://dondi.github.io/GRNsight/index.html>.Support or Funding InformationThis work was partially supported by NSF award 0921038 (K.D.D., B.G.F.), the Kadner‐Pitts Research Grant (K.D.D., M.V.H., K.G.J., N.E.W.) the Loyola Marymount University Summer Undergraduate Research Program 2015 (K.W.W., A.V.), the Loyola Marymount University Rains Research Assistant Program (N.A.A., T.A.M.), and an Loyola Marymount University Honors Summer Research Fellowship (M.V.H., K.G.J., N.E.W.).

To evaluate the use of commercially available allogenic dural graft materials made of fetal bovine collagen, we present an analysis of our case series with use of autologous and allogenic graft materials. Patients who underwent surgical repair of a tegmen tympani defect associated with ipsilateral conductive hearing loss and cerebrospinal fluid (CSF) otorrhea using a middle cranial fossa (MCF) approach from 2004 to 2018 at Loyola University Medical Center were included. Resolution of CSF otorrhea, audiologic outcomes, facial nerve preservation, and surgical complications was analyzed. Thirty-three patients with an average age of 55.3 years (range: 21-78, standard deviation [SD]: 12.9) and body mass index of 34.4 (range: 22-51, SD: 7.4) underwent an MCF repair of a tegmen and dural defect. All patients presented with CSF otorrhea and conductive hearing loss ipsilateral to the defect. Repairs were made with combinations of allograft and autograft in 17 cases, allograft only in 15 cases, and autograft only in 5 cases. Improvement in hearing was noted in 33 cases, and resolution of CSF otorrhea was noted in 36 cases; one patient required repeat surgery which resolved CSF otorrhea. Three patients had minor complications; all these were in the autograft group. The MCF approach coupled with the use of fetal bovine collagen grafts is a safe and viable method to repair tegmen tympani and associated dural defects with salutary outcomes and low morbidity.

GRNsight is a web application and service for visualizing models of gene regulatory networks (GRNs). A gene regulatory network consists of genes, transcription factors, and the regulatory connections between them which govern the level of expression of mRNA and protein from genes. GRNmap, a MATLAB program that performs parameter estimation and forward simulation of a differential equations model of a GRN, can mathematically model the dynamics of GRNs. GRNsight automatically lays out the network graph based on GRNmap output spreadsheets. GRNsight uses pointed and blunt arrowheads, and colors the edges and adjusts their thicknesses based on the sign (activation or repression) and magnitude of the GRNmap weight parameter. Visualizations can be modified through manual node dragging and sliders that adjust the force graph parameters. We have now implemented an exhaustive unit testing framework using Mocha and the Chai assertion library to perform test‐driven development where unit tests are written before new functionality is coded. This framework consists of over 135 automated unit tests that examine about 450 test files to ensure that the program is running as expected. Error and warning messages have a three‐part framework that informs the user what happened, the source of the problem, and possible solutions. For example, GRNsight returns an error when the spreadsheet is formatted incorrectly or the maximum number of nodes or edges is exceeded. The completion of the testing framework marks the close of development for version 1 (the current release stands at version 1.12). In version 2.0 of GRNsight, a new feature will be implemented that colors the nodes (genes) based on the expression data. The user will have the choice to display the experimental data or the data produced by the forward simulation feature in GRNmap. GRNsight is available at http://dondi.github.io/GRNsight/.Support or Funding InformationThis work was partially supported by NSF award 0921038 (B.G.F., K.D.D.), a Kadner‐Pitts Research Grant (K.D.D.), the Loyola Marymount University Summer Undergraduate Research Program (A.V.) and the Loyola Marymount University Rains Research Assistant Program (N.A.A.).

Background. Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) are acute, significant respiratory deteriorations in patients with IPF and can lead to increased morbidity and mortality. It remains unclear how AE-IPF impacts lung transplant (LTX) outcomes. Methods. All adult patients who were listed for LTX between July 2005 and October 2020 at the Loyola University Medical Center with a diagnosis of IPF were included. Pretransplant characteristics and posttransplant outcomes were gathered via retrospective chart review. The primary outcome was short- and long-term survival for patients transplanted during stable IPF versus those with AE-IPF. Results. One hundred fifty-nine patients were included in this study, 17.6% of whom were transplanted during AE-IPF. AE-IPF patients were more likely to have higher oxygen needs pretransplant, have higher lung allocation score, and were more likely to be intubated or be on extracorporeal membrane oxygenation as compared with stable IPF patients. Survival by AE status at transplant did not differ at 90 d or 1 y posttransplantation. There were also no significant differences in rates of severe primary graft dysfunction or acute rejection within 1 y. Conclusions. Patients with AE-IPF were more likely to have higher oxygenation requirements and higher lung allocation score at the time of LTX than those with stable IPF. Despite this, there were no differences in survival at 90 d, 1 y, or 3 y, or differences in incidence of severe primary graft dysfunction or acute cellular rejection. Transplantation of patients with AE-IPF has clinical outcomes comparable with transplantation of patients with stable IPF. This contrasts with previous studies examining LTX in patients with AE-IPF.

Ms Fatima Gailani was appointed as the President of the Afghan Red Crescent Society in 2005. She was born in 1954 in Kabul and is the daughter of Pir Sayed Ahmed Gailani, the leader of the National Islamic Front of Afghanistan, who fought against the Soviet occupation of Afghanistan in the 1980s. She lived in exile during the Soviet invasion of Afghanistan and acted as spokesperson in London for the Afghan Mujahideen. After her return to Afghanistan she was chosen as a delegate to the Emergency Loya Jirga (Grand Council) of June 2002 and was appointed as a constitution-drafting and -ratifying commissioner. Ms Gailani is the author of two books (The Mosques of London and a biography of Mohammad Musa Shafiq).

In this research paper, What the informal system (Jirga) is?, The problems in formal courts system, Judges education and their attitudes and Corruption and individual abuses are discussed. The purpose of the research is to identify The Role of Informal Legal Institutions (Jirga) in the State Building Process in Afghanistan of using descriptive-qualitative methods as well as library resources (documents, books, as well as credible internet sites and articles) This study concludes below: Many times over the past century, Afghan political eliteshave utilized a loya jirga, or grand national assembly, when they have needed to demonstrate national consensus.Based on traditional village jirgas convened to resolve local disputes, loya jirgas have been used to debate and ratify constitutions, endorse the country's position and alliances in times of war, and discuss how and when to engage the afghan government armed opposition groups in peace talks.Currently, three systems regulate disputes in Afghanistan such as State’s laws, Islamic law (Sharia) and informal legal system (Jirga System). But 80% of population exists in local areas with isolated from state; they have turned to Jirga system and rejected state’s system because they perceive it to be corrupt, slow and culturally different Even in many occasions when formal courts fail to solve dispute, according to Doing Justice; they “regularly refer cases to the informal system and accept, record their decision for pending cases.

AbstractFatima Gailani has been serving as the president of the Afghan Red Crescent Society since 2004. She is the daughter of Pir Sayed Ahmed Gailani, the leader of the National Islamic Front of Afghanistan who fought against the Soviet occupation of Afghanistan in the 1980s. After graduating from Malalai High School in Kabul, Ms Gailani obtained a BA and subsequently an MA in Persian Literature and Sufism in 1978 from the National University of Iran. She also earned an MA in Islamic Studies from the Muslim College in London in 1994. She lived in exile during the Soviet invasion of Afghanistan and acted as spokesperson in London for the Afghan Mujahideen. She attended the Bonne Conference on Afghanistan in 2001. After her return to Afghanistan she was chosen as a delegate to the Emergency Loya Jirga – Grand Council – of June 2002 and was appointed as a constitution drafting and ratifying commissioner. Ms Gailani is the author of two books (Mosques of London and a biography of Mohammed Mosa Shafi).

Cold shock treatment of budding yeast, Saccharomyces cerevisiae, causes changes in gene expression, but which transcription factors regulate this response is still unknown. We have observed that strains individually deleted for the Swi4 and Hap4 transcription factors are impaired for growth at cold temperatures. Thus, the purpose of this study was to determine how the transcription factors Swi4 and Hap4 regulate the transcriptional response to cold shock in yeast. BY4741 yeast cells deleted for each transcription factor were subjected to cold shock at 13°C, followed by recovery at 30°C. Samples were collected before cold shock (t0), after 30 and 60 minutes of cold shock (t30, t60), and after 30 and 60 minutes (t90, t120) of recovery at 30°C. Then, total RNA from these cell samples was isolated and aRNA was synthesized and indirectly labeled with the Cy3 and Cy5 dyes, followed by hybridization to DNA microarrays. Four independent replicates of this experiment were performed for each deletion strain, swapping the dye orientation for two of the replicates. An ANOVA test was used to determine which genes had a log2 fold change significantly different than zero at any of the timepoints studied. The results showed that the Δswi4 strain had 2233 out of 6189 (36%) genes with a Benjamini and Hochberg adjusted p value < 0.05. The expression profiles of this set of genes was clustered using the Short Time Series Expression Miner (stem) software. The two most significant expression profiles were up‐regulation during cold shock followed by down‐regulation during recovery, and vice versa. Gene Ontology categories enriched in these profiles included ribosome biogenesis and glycogen metabolic processing, respectively. The ANOVA test performed on the data from the Δhap4 strain showed that 1749 out of 6189 genes (28%) had a Benjamini and Hochberg adjusted p value < 0.05. When this set of genes was subjected to clustering with the stem software, the two most significant expression profiles were up‐regulation followed by a steeper, over‐compensatory down‐regulation which then went back to baseline expression, and a brief period of down‐regulation which also returned to baseline expression. Examples of Gene Ontology categories enriched in these two profiles are carbohydrate transport, and apoptotic processes, respectively. We are in the process of comparing these data to the wild type strain. We have also screened additional transcription factor deletion strains for impaired growth at different temperatures (15°C, 20°C, 30°C, and 37°C). We observed that the Δphd1 strain was impaired for growth at all temperatures, while the Δnrg1 strain was impaired for growth at 30°C and 37°C, but grew more quickly than the wild type strain at 15°C and 20°C, which suggests that these strains may be worthy of future investigation as to cold shock and recovery.Support or Funding InformationThis work was partially supported by NSF award 0921038 (K.D.D.), a Kadner‐Pitts Research Grant (K.D.D., M.V.H.), the Loyola Marymount University Summer Undergraduate Research Program 2015 (K.P.M., K.W.W.), and a Loyola Marymount University Honors Summer Research Fellowship (M.V.H.).

Abstract Disclosure: L.A. Gonzalez-Rodriguez: Research Investigator; Self; Eli Lilly & Company. I.C. Arroyo: None. B. Diaz-Rios: None. L. González-Sepúlveda: None. C.M. Casas-Loyola: None. J. Bermúdez-Santos: None. C. Pérez-Cardona: None. J. Romaguera: None. R. Azziz, MD, MBA, MPH: Advisory Board Member; Self; Arora Forge. Consulting Fee; Self; Rani Therapeutics, Spruce Biosciences, Fortress Biotech, Core Access Surgical Technologies. Grant Recipient; Self; Ferring Pharmaceuticals. Stock Owner; Self; Martin Imaging. PURPOSE: Polycystic Ovary Syndrome (PCOS), a common endocrinopathy affecting women in their reproductive years, is associated with an increased risk for cardiometabolic comorbidities. Even though PCOS is a common condition, there is often a delay in diagnosis and treatment due to several proposed diagnostic criteria. Due to the complexity of this syndrome and different clinical manifestations, it has been recommended to identify their 4 phenotypes. This study aimed to compare the clinical and metabolic characteristics among PCOS-phenotypes in a sample of Hispanic patients. METHODS: This is a cross-sectional study of females between 21-45 years of age with confirmed PCOS using the Rotterdam criteria. Patients were classified according to phenotypes: A, hyperandrogenism (HA), oligoovulation/menstrual dysfunction (OA/MD), and polycystic ovarian morphology (PCOM); B, HA + OA/MD; C, HA + PCOM; D, OA/MD + PCOM. Metabolic Syndrome (MetS) was diagnosed using ATP III criteria. Metabolic characteristics were compared between groups. RESULTS: Sixty-three patients with PCOS were evaluated with phenotypes A (60%), B (21%), C (5%), and D (14%). Only 26 patients (41%) had a previous diagnosis of PCOS. The prevalence of MetS in this sample was 52.4%. Among the phenotypes, phenotype B had the higher prevalence of MetS (61.5%) followed by phenotype D (55.6%) and phenotype A (52.6%). Significant differences in obesity, waist, and hip circumference were found, with phenotype-C having lower parameters (p ≤ 0.05). A tendency for lower BMI, waist-to-hip-ratio, HOMA-IR, and hs-CRP levels was also observed in phenotype-C. CONCLUSION: Our study found a high prevalence of MetS in this sample of patients with PCOS; phenotypes affected by menstrual dysregulation having a higher prevalence. Less than half of patients with PCOS were previously diagnosed despite multiple medical evaluations for symptoms, which emphasizes the importance of an early diagnosis to avoid cardiometabolic complications. Presentation: Thursday, June 15, 2023

IntroductionHeart failure affects over 5 million people in the US. Its rising prevalence coupled with a lack of donor hearts has led to an increase in the use of continuous flow left ventricular assist devices (CF‐VAD). However, patients with CF‐VAD implants are at risk for complications such as non‐surgical bleeding and thrombosis, which significantly increase the risk of patient morbidity and mortality. Identification of novel biomarkers for these events could improve current risk assessment models, treatment, and thus, quality of life for VAD implanted patients.Materials and Methods71 blood samples were collected peri‐operatively and at varying time points post‐operatively from 16 patients implanted with a Thoratec HeartMate II CF‐VAD. Plasma was prepared and stored at −70°C until analysis. Plasma samples collected from normal individuals were used as controls. Samples were analyzed for annexin V‐positive microparticles and microparticles exposing tissue factor, as well as plasma levels of annexin V and C‐reactive protein (CRP) by ELISA. Additionally, surface‐enhanced laser desorption ionization ‐ mass spectrometry (SELDI‐MS) analysis was used to identify changes in biomarker expression. The occurrence of adverse clinical events was determined using an internal RedCap database. CF‐VAD thrombosis was characterized as: cerebrovascular accident/transient ischemic attack diagnosed by a neurologist, rise in LDH or plasma free hemoglobin, hemolysis, evidence of pump dysfunction consistent with thrombus identified by pump parameters, echocardiographic or computed tomographic evidence of clot, or surgical pump exchange for thrombus. CF‐VAD bleeding events were characterized as: anemia and bleeding determined by a cardiologist.ResultsAnnexin V plasma levels were increased approximately 3‐fold compared to normal plasma (9.23 ± 0.85 vs. 2.76 ± 0.2 nM). CRP plasma levels were significantly elevated in CF‐VAD patients compared to normals (14.5 ± 2.7 vs. 2.2 ± 0.6 μg/ml; p=0.034). Although the level of annexin V‐positive microparticles were the same in CF‐VAD patients and normals, the amount of microparticles exposing tissue factor was significantly higher in CF‐VAD patients (3.7 ± 1.1 vs. 0.5 ± 0.1 pg/ml; p=0.038). SELDI‐MS analysis indicated three distinct peaks that were present in CF‐VAD patients, but absent from normals (8.1, 11.7 and 15.2/16.2 kDa). During the follow‐up period, patients experienced 12 CF‐VAD‐related thrombotic events, 8 hemorrhagic events and 2 septic events. The 8.1 kDa biomarker was present in 10/12 patients with a thrombotic event, 2/6 patients with a hemorrhagic event, 0/2 patients experiencing sepsis and 0/2 patients without an adverse event. Positive correlations with the SELDI‐MS peaks and measured parameters were identified: the 8.1 kDa peak was associated with elevated plasma levels of annexin V (p=0.01) and the presence of annexin V‐positive microparticles (p=0.005); the 11.7 kDa peak was associated with elevated plasma levels of CRP (p=0.01); the 15.2/16.2 kDa peaks were associated with the presence of microparticle exposing tissue factor (p=0.002), annexin V‐positive microparticles (p<0.001) and elevated plasma levels of annexin V (p=0.03).ConclusionsDespite treatment with low‐dose aspirin and warfarin, CF‐VAD patients exhibit signs of hemostatic activation. SELDI‐MS may be useful in the identification of novel biomarkers of CF‐VAD‐associated adverse events. This data justifies further evaluation of the utility of the SELDI‐MS to readily identify biomarkers related to adverse clinical events in a larger CF‐VAD population.Support or Funding InformationNational Institutes of Health T35 Trainee Grant. Loyola University Chicago: Dr. Jeske, Dr. Walenga, Dr. Hoppenstaedt, Dr. Fareed and the Department of Thoracic and Cardiovascular Surgery, Heart Failure section of Cardiology and the Department of Medicine and Department of Pathology. National Institutes of Health for funding my work with the T35 trainee grant.

Ushbu maqolada O‘zbekiston Respublikasining Jahon banki, xususan Xalqaro tiklanish va taraqqiyot banki, Xalqaro rivojlanish assotsiatsiyasi va Osiyo taraqqiyot banki bilan hamkorlik aloqalarining amaldagi holati va uni rivojlantirish yo‘llari ko‘rib chiqilgan.  

Editorial Caracterización de especies leñosas en la versión artificial del Bosque de Galería, zona sur del Gran Parque Metropolitano de La Habana / Characterization of woody species in version artificial Forest Gallery, south Park Grand Metropolitan Havana M.Sc. Hilda Quesada-Font, Dr. Yudel García-Quintana, M.Sc. Dulce Almonte-Corzo y Dra. Katia Manzanares-Ayala Determinación de la capacidad antioxidante en extractos de hojas de Tamarindus indica L. en dos estados fisiológicos Determination of the antioxidant capacity in leaf extracts Tamarindus indica L. on two physiological states M.Sc. Adolfo Ramos-Marzán, Dr.C. Julio C. Escalona-Arranz y Dr.C. Jesús Rodríguez-Amado 11 3 Estimación del carbono retenido en el fuste en plantaciones de Pinus cubensis Griseb en la Empresa Forestal Integral Baracoa, Guantánamo, Cuba Estimation of carbon retained in the shaft on Pinus cubensis Griseb on the Integral Forest Enterprise Baracoa, Guantánamo, Cuba Ing. Yosniel Peña-Hernández, Dr.C. José A. Bravo-Iglesias, Dra.C. Juana T. Suárez Sarría, Lic. Lourdes Rodríguez- Shade, Dr.C. Wilmer Toirac-Argüelles, Esp. Víctor M. Fuentes-Utría e Ing. Pedro Rodríguez-Cuevas 17 4 Estimación de variables dasométricas de las plantaciones de Bambusa vulgaris Schrader ex Wendland en áreas del Bosque Modelo Sabanas de Manacas, Villa Clara, Cuba Estimate of dasometric variable plantations of Bambusa vulgaris Schrader ex Wendland in Model Forest Manacas’s Savanna, Villa Clara, Cuba M.Sc. Armando Solano-Cabrera, Dr.C. José A. Bravo-Iglesias y Dr.C. Cristóbal Ríos-Albuerne 23 5 Uso artesanal de la fibra de corteza de Sterculia apetala (Jacq.) Karst The handmade use of the bark fiber of Sterculia apetala (Jacq.) Karst Dr. Adolfo Núñez-Barrizonte y Téc. Antonio Delgado-León 29 6 Comportamiento hidrológico de la regeneración natural de pinares naturales en Alturas de Pizarras, Pinar del Río, Cuba Hidrologic behavior of the natural regeneration of pine plantation in Alturas de Pizarras, Pinar del Río province, Cuba M.Sc. Yolanis Rodríguez-Gil, Ing. Arsenio Renda-Sayoux, Dr.C. Tomás Plasencia-Puentes y Dr.C. Juan A. Herrero-Echavarría 37 7 Evaluación de Moringa oleifera Lam. en cercas vivas en condiciones edafoclimáticas del municipio de Camagüey Evaluation of Moringa oleifera Lam. in alive fences in conditions of climate and floor of the Camagüey municipality Ing. Isael Pérez-Cabrera y Dr.C. Oscar Loyola-Hernández 43 8 Efecto de quemas prescritas sobre las concentraciones de los aniones y cationes en las aguas superficiales Prescribed burns effect over anion and cations concentration in superficial waters M.Sc. Beatriz Rodríguez-Alfaro, Dr.C. Isyoel Urrutia-Hernández, M.Sc. Yaumara Miñoso-Bonilla, Ing. José A. Hernández-Abreu, Dr.C. José G. Flores-Garnica, Dr.C. José A. Bravo-Iglesias, Ing. Arsenio Renda-Sayouz, Ing. Lorenza Martínez-González y Dr.C. Luis W. Martínez-Becerra5 49 9 Flora amenazada de la península de Guanahacabibes, Pinar del Río, Cuba Threatened flora of península de Guanahacabibes, Pinar del Río, Cuba Dra.C. Nancy E. Ricardo-Nápoles, Dr.C. Pedro P. Herrera-Oliver, Dr.C. Francisco Cejas-Rodríguez, M.Sc. Reina Echevarría-Cruz, Dra.C. Sonia Rosete-Blandariz, Téc. Arturo Hernández-Marrero y Téc. Ángel Daniel-Álvarez 55 10 Modelación del carbono retenido en plantaciones de Pinus caribaea Morelet var. caribaea Barret y Golfari en la Unidad Empresarial de Base Silvícola San Vicente, Viñales, provincia de Pinar del Río, Cuba Modeling of retained carbon on plantations of Pinus caribaea Morelet var caribaea Barret and Golfari at the San Vicente Silvicultural Entrepreneurial Unit Base, Viñales, Pinar del Río province, Cuba Ing. Isnaudy García-Rodríguez, Dr.C. José A. Bravo-Iglesias, Dr.C. Juana T. Suárez-Sarría, Ing. Yosniel Peña- Hernández, Esp. Manuel Valle-López e Ing. Roberto Valdés-Roja 65 11 Repetibilidad de parámetros genéticos del banco clonal de Cedrela odorata L. en Guisa, Granma Repetitive of genetic parameters of the clonal bank of Cedrela odorata L. in Guisa, Granma Ing. Wilden Lahera-Fernández, Ing. José L. Rodríguez-Fonseca, Ing. Elier C. Riquenes-Valdés y Luis M. Álvarez-Céspedes 71 12 Usos potenciales de la flora del bosque semideciduo de la Estación Experimental Agroforestal Guisa Flora uses of the forest to the Guisa Agro Forestry Experimental Station M.Sc. William Santos-Chacón Características reproductivas y primeros estadios de plántulas de ratán (Calamus tetradactylus Hance) en las condiciones de Topes de Collantes, Sancti Spíritus, Cuba Reproductive characteristic and first stadiums of sedlings of rattán (Calamus tetradactylus Hance) under the conditions of Topes de Collantes, Sancti Spíritus, Cuba Ing. Jorge León-Acosta, Ing. Miguel Álvarez-González y Esp. Miguel Betancourt- Riquelme 87

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