Journal articles on the topic 'Granulation Tissue Horses Granulation tissue Wound healing'

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1

Watts, E., and M. T. Rose. "Equine limb and oral fibroblasts in in vitro models of cell proliferation and wound contraction." Proceedings of the British Society of Animal Science 2009 (April 2009): 19. http://dx.doi.org/10.1017/s1752756200028581.

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Wound healing in horses is particularly problematic compared to other species and limb wounds often exhibit complications such as exuberant granulation tissue, poor wound contraction and unsightly scars. In comparison, oral wounds heal without scar formation. Therefore, in vitro experiments were conducted to investigate the differences between equine oral and limb fibroblasts in terms of proliferation and their ability to contract a collagen matrix, a commonly used in vitro model of wound contraction.
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2

Yang, Guanghui, Glenn D. Prestwich, and Brenda K. Mann. "Thiolated Carboxymethyl-Hyaluronic-Acid-Based Biomaterials Enhance Wound Healing in Rats, Dogs, and Horses." ISRN Veterinary Science 2011 (January 11, 2011): 1–7. http://dx.doi.org/10.5402/2011/851593.

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The progression of wound healing is a complicated but well-known process involving many factors, yet there are few products on the market that enhance and accelerate wound healing. This is particularly problematic in veterinary medicine where multiple species must be treated and large animals heal slower, oftentimes with complicating factors such as the development of exuberant granulation tissue. In this study a crosslinked-hyaluronic-acid (HA-) based biomaterial was used to treat wounds on multiple species: rats, dogs, and horses. The base molecule, thiolated carboxymethyl HA, was first foun
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3

Du Cheyne, Charis, Ann Martens, and Ward De Spiegelaere. "High Numbers of CD163-Positive Macrophages in the Fibrotic Region of Exuberant Granulation Tissue in Horses." Animals 11, no. 9 (2021): 2728. http://dx.doi.org/10.3390/ani11092728.

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Exuberant granulation tissue (EGT) is a frequently encountered complication during second intention healing in equine distal limb wounds. Although it is still unknown what exactly triggers the formation of this tissue, previous research has revealed a persistent inflammatory response in these wounds. In this preliminary study we examined this inflammatory response in EGT-developing wounds as well as in experimental induced wounds. Immunohistological stainings were performed to detect primary inflammatory immune cells (MAC387 staining) as well as pro-resolution immune cells (CD163 staining). Ou
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4

Mund, Suzanne J. K., Eiko Kawamura, Awang Hazmi Awang-Junaidi, et al. "Homing and Engraftment of Intravenously Administered Equine Cord Blood-Derived Multipotent Mesenchymal Stromal Cells to Surgically Created Cutaneous Wound in Horses: A Pilot Project." Cells 9, no. 5 (2020): 1162. http://dx.doi.org/10.3390/cells9051162.

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Limb wounds on horses are often slow to heal and are prone to developing exuberant granulation tissue (EGT) and close primarily through epithelialization, which results in a cosmetically inferior and non-durable repair. In contrast, wounds on the body heal rapidly and primarily through contraction and rarely develop EGT. Intravenous (IV) multipotent mesenchymal stromal cells (MSCs) are promising. They home and engraft to cutaneous wounds and promote healing in laboratory animals, but this has not been demonstrated in horses. Furthermore, the clinical safety of administering >1.00 × 108 allo
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5

Martins, William Del Conte, Denis Steiner, Arthur Borges Neto, et al. "Graft of Small Patch of Partial Thickness in Equine Wound." Acta Scientiae Veterinariae 46 (January 13, 2018): 7. http://dx.doi.org/10.22456/1679-9216.85126.

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Background: Cutaneous wounds in locomotor limbs represent one of the most frequent disorders in equine medicine. Wounds in equines are distinguished from those in other species by unique characteristics, including different healing rates among breeds, wound location and high propensity to formation of exuberant granulation tissue during the healing process. The wound healing process that cannot be sutured can be accelerated by the use of skin grafts, lowering the treatment cost.The objective of this report was to divulgate the success upon treatment of an extensive lacerated wound in the metat
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6

Barroco, Vanessa, Hanna Caroline Prochno, Tânia Mara Becher Ribas, et al. "The use of a hydrocolloid dressing in the facial wound healing process of a horse - case report." Revista Acadêmica Ciência Animal 14 (February 15, 2016): 203. http://dx.doi.org/10.7213/academica.14.2016.22.

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Hydrocolloid dressing is a bioactive product used to improve the healing process of large open wounds. InMarch 2011, a horse was evaluated at the Veterinary Medical Teaching Hospital- UNICENTRO, Guarapuava,Brazil. The animal presented with epistaxis and inspiratory dyspnoea associated with fracture of the orbitalpart of the frontal bone with a comminuted fracture of the zygomatic process and bone loss of the articulartubercle of the temporal bone reaching the zygomatic process, tooth fracture and a partial laceration of theleft cheek with avulsion of the eyeball. After the reconstructive facia
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7

Miragliotta, Vincenzo, Kevin Raphaël, Zoë Ipiña, Jacques G. Lussier, and Christine L. Theoret. "Equine thrombospondin II and secreted protein acidic and cysteine-rich in a model of normal and pathological wound repair." Physiological Genomics 38, no. 2 (2009): 149–57. http://dx.doi.org/10.1152/physiolgenomics.90383.2008.

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Wound healing in horses is complicated, particularly when wounds are on the limb. The objectives of this study were to clone equine thrombospondin II (THBS2) and secreted protein acidic and cysteine-rich (SPARC) cDNAs and to compare the spatiotemporal expression of mRNAs and proteins during repair of body and limb wounds. These molecules were targeted in view of their potential biological contribution to angiogenesis, which is exacerbated during the repair of limb wounds in horses. Cloning was achieved by screening size-selected cDNA libraries previously derived from 7-day-old wounds. Expressi
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8

Busato, Eduarda Maciel, Jéssica Rodrigues Silva-Meirelles, Monalisa Lukascek de Castro, et al. "Trans-endoscopic ventriculocordectomy in horses using monopolar electrocautery." Semina: Ciências Agrárias 38, no. 5 (2017): 3363. http://dx.doi.org/10.5433/1679-0359.2017v38n5p3363.

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Laryngeal hemiplegia is one of the most common upper airway affections in horses. Laringoplasty is indicated in high-performance animals, and when the only complaint is noisy breathing, ventriculectomy and cordectomy can be performed. This study aimed to establish a minimally invasive surgical approach to ventriculocordectomy in horses, through a videoendoscopic procedure. The technique was developed in two stages, the first one was a cadaveric study and the second one was in vivo, both using two flexible endoscopes. A bilateral ventriculocordectomy was performed in two cadavers, totaling the
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9

Berry II, Douglass B., and Kenneth E. Sullins. "Effects of topical application of antimicrobials and bandaging on healing and granulation tissue formation in wounds of the distal aspect of the limbs in horses." American Journal of Veterinary Research 64, no. 1 (2003): 88–92. http://dx.doi.org/10.2460/ajvr.2003.64.88.

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10

Jimi, Shiro, Satoshi Takagi, Francesco De Francesco, Motoyasu Miyazaki, and Arman Saparov. "Acceleration of Skin Wound-Healing Reactions by Autologous Micrograft Tissue Suspension." Medicina 56, no. 7 (2020): 321. http://dx.doi.org/10.3390/medicina56070321.

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Background and objectives: Skin grafting is a method usually used in reconstructive surgery to accelerate skin regeneration. This method results frequently in unexpected scar formations. We previously showed that cutaneous wound-healing in normal mice is accelerated by a micrograft (MG) technique. Presently, clinical trials have been performed utilizing this technology; however, the driving mechanisms behind the beneficial effects of this approach remain unclear. In the present study, we focused on five major tissue reactions in wound-healing, namely, regeneration, migration, granulation, neov
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11

Komelyagina, Elena Yur'evna, Eugenia Alexandrovna Kogan, and Mikhail Borisovich Antsiferov. "Clinical and morphological characteristics of wound healing in diabetic foot syndrome." Diabetes mellitus 20, no. 2 (2017): 135–41. http://dx.doi.org/10.14341/7704.

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Aim. To assess the clinical and morphological characteristics of neuropathic diabetic foot ulcers (DFUn)
 Materials and Methods.Forty-three specimens of DFUn were analysed. Depending on the outcome, samples were divided into 2 groups: group 1healed ulcers (30 samples), group 2unhealed ulcers (13 samples). The following characteristics were analysed: age, sex, glycated haemoglobin (HbA1c), ulcer duration, time of admission to the specialised clinic, severity of neuropathy, presence of late complications, plantar localisation, percentage of necrotic tissue, granulation and fibrotic tissue a
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12

Ramamurthy, N. S., A. J. Kucine, S. A. McClain, T. F. McNamara, and L. M. Golub. "Topically Applied Cmt-2 Enhances Wound Healing in Streptozotocin Diabetic Rat Skin." Advances in Dental Research 12, no. 1 (1998): 144–48. http://dx.doi.org/10.1177/08959374980120011001.

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Delayed wound healing is one of the complications of diabetes mellitus, exhibited by increased wound collagenase and decreased granulation tissues. The current study compared wound healing in normal and diabetic rats, and the effects of topically applied 1 % or 3% concentrations of chemically modified tetracycline-2 (CMT-2) on 6-mm circular full-thickness skin wounds healed by secondary intention. On day 7 after wounding, tissues were removed for biochemical analysis and histology. The wound granulation tissue hydroxyproline was less in the untreated diabetic rat with increased collagenase and
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13

Upadhyay, Aadesh, Pronobesh Chattopadhyay, Danswrang Goyary, Papiya M. Mazumder, and Vijay Veer. "Topical Application ofCleome viscosaIncreases the Expression of Basic Fibroblast Growth Factor and Type III Collagen in Rat Cutaneous Wound." BioMed Research International 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/680879.

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Cleome viscosaL. (Cleomaceae) is an important traditional medicine of the Indian-Ayurvedic and Chinese-medicine system documented for rheumatic arthritis, hypertension, malaria, neurasthenia, and wound healing. The plant is also known as Asian spider flower and is distributed throughout the greater part of India. The present study explored the wound healing property ofC. viscosamethanol extract (CvME) and its related mechanism using Wistar rat cutaneous excision wound model. Wound contraction rate, hydroxyproline quantification, and histopathological examination of wound granulation tissue wer
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14

Bhan, Surya, Rahul Mitra, A. K. Arya, H. P. Pandey, and K. Tripathi. "A Study on Evaluation of Apoptosis and Expression of Bcl-2-Related Marker in Wound Healing of Streptozotocin-Induced Diabetic Rats." ISRN Dermatology 2013 (October 7, 2013): 1–6. http://dx.doi.org/10.1155/2013/739054.

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Uncontrolled blood sugar is a major cause of vascular complications and delayed wound healing in diabetes mellitus. During wound healing process, normally, apoptosis is responsible for events such as removal of inflammatory cells and evolution of granulation tissue into scar which occur during the late phase of wound healing. Early apoptosis can lead to abnormal wound healing by removing granulation tissue including fibroblast, endothelial cell, and small vessels. To determine the role of apoptosis in association with hyperglycemia in diabetic wound healing, apoptosis-related intracellular mar
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15

Krishnaprasad, I. N., V. Soumya, and S. Abdulgafoor. "Management of Over-Granulation in a Diabetic Foot Ulcer: A Clinical Experience." Indian Journal of Physical Medicine and Rehabilitation 24, no. 1 (2013): 19–22. http://dx.doi.org/10.5005/ijopmr-24-1-19.

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Abstract Over-granulation or exuberant granulation tissue is a common problem encountered in the care of chronic wounds, especially that of diabetic foot ulcers. There are several potential options for the treatment of this challenging problem. Some have an immediate short term effect but may have a longer term unfavourable effect, for example, silver nitrate application and surgical excision, which may delay wound healing by reverting the wound back to the inflammatory phase of healing. Other products, such as foams and silver dressings may offer some effect in short term, but their long term
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16

Hakkinen, L., and H. Larjava. "Characterization of Fibroblast Clones from Periodontal Granulation Tissue in vitro." Journal of Dental Research 71, no. 12 (1992): 1901–7. http://dx.doi.org/10.1177/00220345920710120901.

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Connective tissues are known to be composed of heterogeneous fibroblast subpopulations. The significance of this heterogeneity in different physiological and pathological conditions is poorly understood. Granulation tissue is formed in connective tissue during wound healing, chronic inflammation, and certain pathological conditions. In this study, heterogeneity of fibroblasts from granulation tissue was investigated by cell-cloning techniques. Granulation-tissue fibroblasts (GTFs) from both chronically inflamed periodontal lesions and healing wound granulation tissue behaved similarly. GTFs sh
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17

Kaushal, Mandeep, N. Gopalan Kutty, and C. Mallikarjuna Rao. "Nitrooxyethylation Reverses the Healing-Suppressant Effect of Ibuprofen." Mediators of Inflammation 2006 (2006): 1–7. http://dx.doi.org/10.1155/mi/2006/24396.

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Nonsteroidal antiinflammatory drugs like ibuprofen impede tissue repair by virtue of retarding inflammation. The present study was undertaken to explore if linking of nitrooxyethyl ester to ibuprofen reverses its healing-depressant propensity. Nitrooxyethyl ester of ibuprofen (NOE-Ibu) was synthesized in our laboratory through a well-established synthetic pathway. NOE-Ibu was screened for its influence on collagenation, wound contraction and epithelialization phases of healing, and scar size of healed wound in three wound models, namely, incision, dead space, and excision wounds. Besides, its
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18

Maisuria, Rushabh, Jawansing Manza, Devendra Chaudhari, and Divyang Dave. "Observational study of the effects of silver-based dressing materials in 50 cases of diabetic foot ulcers." International Surgery Journal 6, no. 2 (2019): 508. http://dx.doi.org/10.18203/2349-2902.isj20190393.

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Background: Diabetic foot remains the most common chronic medical problem being the most common cause of the hospital visit and/or admission, amongst the diabetic patients. Topical antimicrobial dressings, including those that contain silver are used to prevent or manage infection in a wide range of wounds.Methods: This is the prospective, observational study which included 50 cases of diabetic foot ulcer patients and effects of silver-based dressing materials will be evaluated.Results: After application of silver based dressing materials for two weeks, wound was evaluated on the basis of disc
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19

Younis, Ibby. "Role of oxygen in wound healing." Journal of Wound Care 29, Sup5b (2020): S4—S10. http://dx.doi.org/10.12968/jowc.2020.29.sup5b.s4.

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Not only does oxygen play an essential role in each stage of the wound healing process. It also helps to increases host resistance to infection. Any impairment to the oxygen supply can therefore delay healing. This article explores the affects of oxygen on the wound cells and tissue, and explains how an adequate supply is required for granulation tissue formation and epithelialisation to occur
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20

Amaral, Lívia Gomes, Emily Correna Carlo Reis, Natália Alves Fernandes, Andrea Pacheco Batista Borges, Fabrício Luciani Valente, and Rodrigo Viana Sepulveda. "Biodegradable polymer nanofiber membrane for the repair of cutaneous wounds in dogs - two case reports." Semina: Ciências Agrárias 37, no. 6 (2016): 4171. http://dx.doi.org/10.5433/1679-0359.2016v37n6p4171.

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The study of wound healing and its treatment is extremely important in veterinary medicine due to the high frequency of wounds and the difficulty in treating wounds by second intention. Thus, the objective of this study was to evaluate the use of a nanofiber membrane made of biodegradable polymers as a method of wound treatment in dogs. This study comprised two dogs with bite wounds. Debridement and cleaning was performed followed by the application of the membrane. In one dog, the wound was in the left proximal calcaneal region with clinical signs of infection, necrotic tissue, and muscle and
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21

Liu, Yu, Ningning Tang, Ke Cao, et al. "Negative-Pressure Wound Therapy Promotes Wound Healing by Enhancing Angiogenesis Through Suppression of NLRX1 via miR-195 Upregulation." International Journal of Lower Extremity Wounds 17, no. 3 (2018): 144–50. http://dx.doi.org/10.1177/1534734618794856.

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Negative-pressure wound therapy (NPWT) is one of the most advanced therapeutic methods in the treatment of various hard-to-heal acute and refractory chronic wounds. Recent emerging evidence points to a role of the microRNA-mediated regulation of angiogenesis in ischemic tissues, and a series of microRNAs associated with angiogenesis have been successively identified. In this study, we found that miR-195 expression was significantly upregulated and the microvessel density (MVD) was increased in granulation tissue collected 7 days after NPWT compared with those in the pre-NPWT tissue. Moreover,
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22

Schuster, Rob, Arash Moradzadeh, and Kenneth Waxman. "The Use of Vacuum-Assisted Closure Therapy for the Treatment of a Large Infected Facial Wound." American Surgeon 72, no. 2 (2006): 129–31. http://dx.doi.org/10.1177/000313480607200206.

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Chronic wounds in difficult locations pose constant challenges to health care providers. Negative-pressure wound therapy is a relatively new treatment to promote wound healing. Laboratory and clinical studies have shown that the vacuum-assisted closure (VAC) therapy increases wound blood flow, granulation tissue formation, and decreases accumulation of fluid and bacteria. VAC therapy has been shown to hasten wound closure and formation of granulation tissue in a variety of settings. Accepted indications for VAC therapy include the infected sternum, open abdomen, chronic, nonhealing extremity w
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23

Dash, G. K., and P. N. Murthy. "Studies on Wound Healing Activity of Heliotropium indicum Linn. Leaves on Rats." ISRN Pharmacology 2011 (April 12, 2011): 1–8. http://dx.doi.org/10.5402/2011/847980.

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The petroleum ether, chloroform, methanol, and aqueous extracts of Heliotropium indicum Linn. (Family: Boraginaceae) were separately evaluated for their wound healing activity in rats using excision (normal and infected), incision, and dead space wound models. The effects of test samples on the rate of wound healing were assessed by the rate of wound closure, period of epithelialisation, wound breaking strength, weights of the granulation tissue, determination of hydroxyproline, super oxide dismutase (SOD), catalase, and histopathology of the granulation tissues. Nitrofurazone (0.2% w/w) in si
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Zahid, Muhammad, Maria Lodhi, Zulfiqar Ahmad Rehan, et al. "Sustainable Development of Chitosan/Calotropis procera-Based Hydrogels to Stimulate Formation of Granulation Tissue and Angiogenesis in Wound Healing Applications." Molecules 26, no. 11 (2021): 3284. http://dx.doi.org/10.3390/molecules26113284.

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The formation of new scaffolds to enhance healing magnitude is necessarily required in biomedical applications. Granulation tissue formation is a crucial stage of wound healing in which granulation tissue grows on the surface of a wound by the formation of connective tissue and blood vessels. In the present study, porous hydrogels were synthesized using chitosan incorporating latex of the Calotropis procera plant by using a freeze–thaw cycle to stimulate the formation of granulation tissue and angiogenesis in wound healing applications. Structural analysis through Fourier transform infrared (F
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25

Steenfos, H. H., and J. O. Jansson. "Growth hormone stimulates granulation tissue formation and insulin-like growth factor-I gene expression in wound chambers in the rat." Journal of Endocrinology 132, no. 2 (1992): 293–98. http://dx.doi.org/10.1677/joe.0.1320293.

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ABSTRACT It has been reported that GH stimulates fibroblast growth and wound healing. In the present study we measured the effect of locally applied GH on insulin-like growth factor (IGF-I) mRNA concentrations and granulation tissue formation in wound cylinders, implanted s.c. Four stainless-steel wiremesh cylinders were implanted s.c. in the back of male rats (280 g). Each cylinder was then injected every day with either 0·014 or 0·14 U human GH, or vehicle only. Ingrown granulation tissue and wound fluid was obtained on day 17 after implantation. The wet weight of granulation tissue was dete
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26

Mosti, G. "Wound care in venous ulcers." Phlebology: The Journal of Venous Disease 28, no. 1_suppl (2013): 79–85. http://dx.doi.org/10.1177/0268355513477015.

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Wound dressings: ulcer dressings should create and maintain a moist environment on the ulcer surface. It has been shown that in an ulcer with a hard crust and desiccated bed, the healing process is significantly slowed and sometimes completely blocked so favouring infection, inflammation and pain. In contrast a moist environment promotes autolytic debridement, angiogenesis and the more rapid formation of granulation tissue, favours keratinocytes migration and accelerates healing of wounds. Apart from these common characteristics, wound dressings are completely different in other aspects and mu
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27

Gniadecki, R., and J. Serup. "Enhancement of the granulation tissue formation in hairless mice by a potent vitamin D receptor agonist – KH 1060." Journal of Endocrinology 141, no. 3 (1994): 411–15. http://dx.doi.org/10.1677/joe.0.1410411.

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Abstract KH 1060 is a 20-epi analogue of 1,25-dihydroxyvitamin D3 and a potent agonist of the vitamin D receptor. Our recent finding that it stimulates glycosaminoglycan synthesis and transforming growth factor-β1 (TGF-β1) expression in normal skin provided a rationale for investigating its influence on the process of wound healing. Normal and betamethasone-impaired granulation tissue formation was studied in a polytetrafluoroethylene dead space model in hairless mice. The application of KH 1060 increased the indexes of fibroplasia and cellularity ([3H]thymidine incorporation and DNA concentra
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28

Gimranov, V. V., and I. T. Giniyatullin. "EEFECT OF SUBTILIN OINTMENT ON MORPHOLOGICAL INDICATORS OF WOUND HEALING IN RABBITS." VESTNIK OF THE BASHKIR STATE AGRARIAN UNIVERSITY 54, no. 4 (2019): 80–86. http://dx.doi.org/10.31563/1684-7628-2019-52-4-80-86.

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The paper studies the effect of applying probiotics based Subtilin ointment on morphological indicators of the experimental wound healing in rabbits. The study showed that 3 days after traumatic skin damage and applying Subtilin ointment tissue necrosis was found on the tissue specimen. Marked cell infiltration in interfascicular spaces and swollen collagen fibers were found deep in the skin. The wound surface was covered with a thick fibrin and tissue crust. On day 7 active regeneration of the epithelium proliferating under the crust was observed. Native granulation tissue formed under the ne
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29

Tanideh, Nader, Farideh Keshavarzi, Aida Hemat Zadeh, et al. "Healing Effects of Human Amniotic Membrane and Burned Wool on the Second-degree Burn in Rats." Galen Medical Journal 9 (December 18, 2020): 1759. http://dx.doi.org/10.31661/gmj.v9i0.1759.

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ackground: This study aimed to compare sheep burnt wool and human amniotic membrane (AM) on second-degree burn wound healing in rats. Materials and Methods: Seventy-two adult male rats of Sprague Dawley underwent general anesthesia, and a deep second-degree burn was created on their skin by a hot iron plate. Afterward, human AM, silver sulfadiazine ointment (SSD), and sheep burned wool were used on wound area for burn treatment. On days 7, 14, and 21 of the experiment, the rats were sacrificed, and histopathological assessments were done. Results: Human AM, in comparison with other groups, sig
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Brown, Mark T., and William W. Montgomery. "Microbiology of Tracheal Granulation Tissue Associated with Silicone Airway Prostheses." Annals of Otology, Rhinology & Laryngology 105, no. 8 (1996): 624–27. http://dx.doi.org/10.1177/000348949610500807.

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Granulation tissue formation and contraction is inevitable during the healing of open wounds. The presence of infection and a foreign body, such as a silicone airway prosthesis or other tracheotomy tube, magnifies this response. In airway reconstruction, wound contraction secondary to chronic inflammation is a liability. Cultures of granulation tissue were taken from 12 patients with silicone cannulas of T-Tubes. Polymicrobial colonization predominated, with variable combinations of gram-positive, gram-negative, and anaerobic organisms being present. On the basis of sensitivity data, amoxicill
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31

Gautam, M. K., V. Purohit, M. Agarwal, A. Singh, and R. K. Goel. "In VivoHealing Potential ofAegle marmelosin Excision, Incision, and Dead Space Wound Models." Scientific World Journal 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/740107.

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The study incorporates the wound healing potential ofAegle marmelosfruit pulp extract (AME) on excision, incision, and dead space wound models in rats. AME (200 mg/kg) was administered orally once daily for variable days depending on the type of wound ulcer study. AME was studied for its wound breaking strength (incision wound), rate of contraction, period of epithelization and histology of skin (excision model), and granulation tissue free radicals, antioxidants, acute inflammatory marker, and connective tissue markers and deep connective tissue histology (dead space wound). Complete wound co
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32

Takayama, Yoshiharu, and Reiji Aoki. "Roles of lactoferrin on skin wound healing1This article is part of Special Issue entitled Lactoferrin and has undergone the Journal's usual peer review process." Biochemistry and Cell Biology 90, no. 3 (2012): 497–503. http://dx.doi.org/10.1139/o11-054.

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Skin wound healing is a complex biological process that requires the regulation of different cell types, including immune cells, keratinocytes, fibroblasts, and endothelial cells. It consists of 5 stages: hemostasis, inflammation, granulation tissue formation, re-epithelialization, and wound remodeling. While inflammation is essential for successful wound healing, prolonged or excess inflammation can result in nonhealing chronic wounds. Lactoferrin, an iron-binding glycoprotein secreted from glandular epithelial cells into body fluids, promotes skin wound healing by enhancing the initial infla
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33

M, Sandesh. "A comparative study of phenytoin dressing versus honey dressing in the treatment of cronic ulcers in tertiary care hospital." MedPulse International Journal of Surgery 19, no. 1 (2021): 05–09. http://dx.doi.org/10.26611/1061912.

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Background: Diabetic foot infections are the leading cause of hospitalization morbidity and mortality in diabetics worldwide In India it accounts for 20% of hospitalizations. honey has been investigated to treat ulcers like pressure ulcers, venous ulcers, diabetic ulcers, traumatic wounds and burns. Phenytoin is also now known to promote wound healing and can be an alternative to normal saline specifically in chronic wounds related to diabetes. The present study compares these two modalities in management of diabetic ulcers. Objective: To compare the efficacy of topical phenytoin vs topical ho
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Berlanga-Acosta, Jorge, Gregory S. Schultz, Ernesto López-Mola, Gerardo Guillen-Nieto, Marianela García-Siverio, and Luis Herrera-Martínez. "Glucose Toxic Effects on Granulation Tissue Productive Cells: The Diabetics’ Impaired Healing." BioMed Research International 2013 (2013): 1–15. http://dx.doi.org/10.1155/2013/256043.

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Type 2 diabetes mellitus is a metabolic noncommunicable disease with an expanding pandemic magnitude. Diabetes predisposes to lower extremities ulceration and impairs the healing process leading to wound chronification. Diabetes also dismantles innate immunity favoring wound infection. Amputation is therefore acknowledged as one of the disease’s complications. Hyperglycemia is the proximal detonator of systemic and local toxic effectors including proinflammation, acute-phase proteins elevation, and spillover of reactive oxygen and nitrogen species. Insulin axis deficiency weakens wounds’ anabo
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Chen, Bing-Kun, Kristin M. Leiferman, Mark R. Pittelkow, Michael T. Overgaard, Claus Oxvig, and Cheryl A. Conover. "Localization and Regulation of Pregnancy-Associated Plasma Protein A Expression in Healing Human Skin." Journal of Clinical Endocrinology & Metabolism 88, no. 9 (2003): 4465–71. http://dx.doi.org/10.1210/jc.2003-030193.

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Pregnancy-associated plasma protein A (PAPP-A) is an IGF-binding protein-4 (IGFBP-4) metalloproteinase that cleaves inhibitory IGFBP-4 to amplify local IGF-I bioavailability in vitro. Thus it has functional implications in injury/repair responses. In this study we determined PAPP-A expression in healing human skin. Wounds were induced with a scalpel on the forearms of three normal subjects and were allowed to heal by first intention. Biopsies obtained on d 0, 2, 8, and 14 were processed for immunohistochemical detection of PAPP-A, IGF-I, and IGFBP-4. In uninjured skin (d 0), strong staining fo
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Shaheed, Nusrat, A. S. M. Jahangir Chowdhury, Anadi Ranjan Mondal, et al. "Negative Pressure Wound Therapy (NPWT) in open wound management: A study of 16 Cases in Orthopaedic Department of Faridpur Medical College Hospital." Faridpur Medical College Journal 7, no. 2 (2013): 63–66. http://dx.doi.org/10.3329/fmcj.v7i2.13500.

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Wound management is a major concern in open fracture cases. Negative Pressure Wound Therapy (NPWT) is an advanced method for managing open wounds. It is a topical treatment using sub-atmospheric pressure to increase blood flow, remove bacteria and increase growth of granulation tissue in the wound. The study was performed to evaluate the results of NPWT in patients with open fracture in lower extremity. Using Aquarium pump as an NPWT device, 16 patients were prospectly treated for open fractures in their inferior extremity. Mean patients' age range was 21 to 60 yrs. The patients under study ei
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Kamal, Aqsa, Basheer Salman, Noor Hayati Abdul Razak, Ali Al Qabbani, and A. R. Samsudin. "The Efficacy of Concentrated Growth Factor in the Healing of Alveolar Osteitis: A Clinical Study." International Journal of Dentistry 2020 (May 12, 2020): 1–9. http://dx.doi.org/10.1155/2020/9038629.

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Background. A dry socket also referred to as alveolar osteitis (AO) is a common postoperative complication following tooth extraction, due to the disruption of the clot within the wound. This study aimed to evaluate the efficacy of concentrated growth factor (CGF) in the healing of alveolar osteitis following tooth extraction. Methods. The study was conducted at University Dental Hospital Sharjah, UAE. Patients undergoing tooth extraction at the oral surgery clinic were advised to return immediately if they suffer from pain. Over the following first week after tooth extraction, patients who re
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C, Shengjun, Lingfeng W, Te B, Xue F, Fang L, and Chunguang H. "Effects of allogeneic mouse adipose-derived mesenchymal stem cell-microporous sheep acellular dermal matrix on healing of wound with full-thickness skin defect in mouse and the related mechanism." Discussion of Clinical Cases 6, no. 2 (2019): 26. http://dx.doi.org/10.5430/dcc.v6n2p26.

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Objective: To explore the effects of allogeneic mouse adipose-derived mesenchymal stem cell (ADSC)-microporous sheep acellular dermal matrix (ADM) on wound healing of full-thickness skin defect in mice and the related mechanism.Methods: One Kunming mouse was sacrificed by cervical dislocation to collect adipose tissue from the inguinal region. Mouse ADSCs were isolated from the adipose tissue and cultured in vitro. Cells in the third passage were identified by cell adipogenic and osteogenic differentiation. The expressions of CD34, CD73, CD90, and CD105 were analyzed by flow cytometer. After o
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Haroon, Zishan A., Thung S. Lai, and Charles S. Greenberg. "Tissue Transglutaminase Enhances Fibrin-Dependent Angiogenesis and Extracellular Matrix Formation by Altering Gene Expression during Wound Healing." Blood 104, no. 11 (2004): 2626. http://dx.doi.org/10.1182/blood.v104.11.2626.2626.

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Abstract Fibrin deposition triggers an injury response that involves the migration of inflammatory cells formation of new blood vessels and the synthesis of extracellular matrix (ECM). Tissue transglutaminase (TTG) is a calcium dependent enzyme that covalently crosslinks a wide variety of ECM proteins producing a protease resistant matrix. TTG is secreted by inflammatory and endothelial cells, involved in activating transforming growth factor beta-1 (TGF beta-1) and expressed during wound healing response. In this study, we investigated how TTG modulated fibrin-dependent wound healing and the
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Marty, Gary D. "Wound Healing in Channel Catfish by Epithelialization and Contraction of Granulation Tissue." Transactions of the American Fisheries Society 119, no. 1 (1990): 145–50. http://dx.doi.org/10.1577/1548-8659(1990)119<0145:whiccb>2.3.co;2.

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Medeiros Soares Celani, Livia, Isadora Soares Lopes, and Aldo Cunha Medeiros. "The effect of hyaluronic acid on the skin healing in rats." JOURNAL OF SURGICAL AND CLINICAL RESEARCH 10, no. 2 (2019): 65–75. http://dx.doi.org/10.20398/jscr.v10i2.18824.

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Purpose: The objective of this study was to examine the effect of topical hyaluronic acid (HA) treatment on wound healing in rats. Methods: Wistar rats were randomly selected and allocated into 2 groups, with six rats each, all of them submitted to skin lesions (open wound with 5mm diameter). Group 1 – rats treated with topical 0,9% saline application in skin wounds. Group 2 – rats treated with topical hyaluronic acid 0,4% on skin wounds once a day for 7 days. After anesthesia on the 7th postoperative day, a biopsy of the skin dorsal wound area was performed for histopathological examination.
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FITZGERALD, A. M. P., J. J. R. KIRKPATRICK, and I. L. NAYLOR. "Dupuytren’s Disease." Journal of Hand Surgery 24, no. 4 (1999): 395–99. http://dx.doi.org/10.1054/jhsb.1999.0207.

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Histologically, Dupuytren’s disease has been compared to the process of neoplasia because of fibroblast proliferation, recurrence, chromosomal abnormalities and antigenic profiles. However, a comparison of Dupuytren’s tissue with the granulation tissue formed in wound healing could be more valid. Histology reveals similarities in cell types, proliferation, vascularity and collagen morphology. Pharmacologically, both tissues have a similar range of agonist and antagonist responses. Biochemical analysis reveals new collagen synthesis, an increased ratio of type III to type I collagen, and simila
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Fortuna, Fory, Nandita Melati Putri, and Gentur Sudjatmiko. "Granulation Red Index To Assess Pressure Ulcer Granulation Tissue Quality Treated By Honey Gauze Dressing By Digital Image Analysis." Jurnal Plastik Rekonstruksi 6, no. 2 (2020): 270–75. http://dx.doi.org/10.14228/jpr.v6i2.284.

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Background : Good formation of granulation tissue in the ulcer bed is regarded as one of the indicators of pressure ulcer healing. Granulation red index (GRI) had been published as an objective parameter to assess the quality of granulation tissue. Honey stimulates granulation of tissue and creates a moist healing environment. However, the assessment of granulation tissue quality of pressure ulcers treated by honey has yet to be proven in clinical settings. In this study, we evaluate the granulation tissue quality of pressure ulcers treated by honey using granulation red index by digital image
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Sukarno, Anita, Nur Hidayah, and Musdalifah Musdalifah. "EFFECTIVITY OF INDONESIAN HONEY ON DIABETIC FOOT ULCERS HEALING PROCESS: OBSERVATIONAL CASE STUDY." International Journal of Nursing and Health Services (IJNHS) 2, no. 2 (2019): 20–28. http://dx.doi.org/10.35654/ijnhs.v2i2.88.

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Background: Diabetic foot ulcers were common diabetes complication that progressively growth globally. The effectivity of Manuka honey in wound healing process was huge published currently. Modern dressing and Manuka honey may not affordable and cost effective since these dressings were not produced originally in Indonesia. In addition, the published study of Indonesian honey is still lack. Therefore, we conducted this study to investigate the effectivity of Indonesian honey in diabetic foot ulcers healing process.&#x0D; Method: This study design was observational case study. This study was co
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Zaitseva, Ekaterina L., Alla Y. Tokmakova, Iya A. Voronkova, Vasily M. Petrov, Anatoly N. Tiulpakov, and Marina V. Shestakova. "Genetic parameters of wound healing in patients with neuropatic diabetic foot ulcers." Diabetes mellitus 20, no. 5 (2017): 344–49. http://dx.doi.org/10.14341/dm9291.

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Background. Tissue repair processes are impaired in diabetic foot ulcers (DFUs). Previous research has shown that glycaemic control, cytokines and growth factors play an important role in wound healing. Emerging evidence also suggests that genes play a role via their regulation of cell proliferation, collagen synthesis and granulation tissue formation.&#x0D; Aim. To evaluate collagen genes expression in different stages of wound healing in patients with DFUs.&#x0D; Materials and methods. Prospective study included four patients with neuropathic DFUs after surgical debridement. Tissue samples w
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Serrano, C., A. Ortilles, A. Diaz, and A. Whyte. "Corticoids as a treatment to control complications arising after reconstructive surgery of the skin: a case report." Veterinární Medicína 62, No. 7 (2017): 406–9. http://dx.doi.org/10.17221/154/2016-vetmed.

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Corticosteroids are not indicated in wound healing, but the intralesional and topical administration of these agents has been described to control tissue overgrowth in humans. The aim of the present study was to assess the use of topical corticosteroids to control pre- and post-surgical tissue overgrowth in a 5-year-old male Belgian shepherd weighing 33.5 kg. We report successful use of topical administration of corticosteroids to treat granulation tissue overgrowth before and after skin grafting. Corticosteroids are a safe and easy way to treat this complication and can be used to prepare a h
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Mohd Zubir, Mohd Zurairie, Samantha Holloway, and Norhayati Mohd Noor. "Maggot Therapy in Wound Healing: A Systematic Review." International Journal of Environmental Research and Public Health 17, no. 17 (2020): 6103. http://dx.doi.org/10.3390/ijerph17176103.

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Background: It is estimated that 2% of the population in developing countries suffer from a chronic wound, making it a hidden phenomenon that is increasing as populations age. The ease of access to maggot therapy has made it increasingly attractive for implementation. This study aimed to explore the effectiveness of maggot therapy as compared to hydrogel dressings in the healing of chronic wounds. Methods: An electronic literature search until October 2019 was performed using Medline, Embase, and Cumulative Index of Nursing and Allied Health Literature. The eligibility criteria were chronic wo
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Khurram, Mohammed Fahud, Sheikh Sarfraz Ali, and Mohammad Yaseen. "Vacuum-Assisted Wound Closure Therapy in Pediatric Lower Limb Trauma." International Journal of Lower Extremity Wounds 18, no. 3 (2019): 317–22. http://dx.doi.org/10.1177/1534734619857403.

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Although the importance of vacuum-assisted wound closure therapy has been well established as road to definitive treatment of trauma wound in the adult population, its use in pediatric patients is not well described in the literature. This study was conducted to evaluate the outcome of vacuum-assisted wound closure therapy in pediatric patients. Twenty-two patients were prospectively treated for soft tissue defect in lower limb using vacuum-assisted wound closure device, as these wounds were not amenable for primary closure. After wound evaluation, thorough wound debridement was done. Vacuum-a
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Elenius, K., S. Vainio, M. Laato, M. Salmivirta, I. Thesleff, and M. Jalkanen. "Induced expression of syndecan in healing wounds." Journal of Cell Biology 114, no. 3 (1991): 585–95. http://dx.doi.org/10.1083/jcb.114.3.585.

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We have studied the expression of an integral cell surface proteoglycan, syndecan, during the healing of cutaneous wounds, using immunohistochemical and in situ hybridization methods. In normal mouse skin, both syndecan antigen and mRNA were found to be expressed exclusively by epidermal and hair follicle cells. After incision and subsequent suturing, remarkably increased amounts of syndecan on the cell surfaces of migrating and proliferating epidermal cells and on hair follicle cells adjacent to wound margins were noted. This increased syndecan expression was shown to be a consequence of grea
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Vanscheidt, W., A. Laubert, H. Laaff, J. M. Weiss, and E. Schöpf. "Immunohistochemical Localization of Factor XIIIa in Chronic Venous Insufficiency." Phlebology: The Journal of Venous Disease 9, no. 1 (1994): 41–45. http://dx.doi.org/10.1177/026835559400900112.

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Objective: Factor XIIIa (FXIIIa) of the coagulation cascade (fibrin stabilizing factor) plays a crucial role in wound healing. Its plasma activity is significantly decreased in patients suffering from diseases accompanied with pathologically increased uptake of fibrin. Design: Immunohistochemical localization of FXIIIa and immunofluorescent histological labelling of fibrin in patients' biopsies and in control specimens. Procedure: Twenty-five biopsies were taken from granulation tissue of venous ulcers. Specimens of unimpaired wound healing ( n = 10) served as controls. Concentrations of FXIII
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