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Dissertations / Theses on the topic 'Granules RNP'

Author: Grafiati

Published: 24 June 2021

Last updated: 29 July 2025

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1

Cid, Samper Fernando 1991. "Computational approaches to characterize RNP granules." Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/668449.

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Ribonucleoprotein granules (RNP granules) are liquid-liquid phase separated complexes composed mainly by proteins and RNA. They are responsible of many processes involved in RNA regulation. Alterations in the dynamics of these proteinRNA complexes are associated with the appearance of several neurodegenerative disorders such as Amyotrophic Lateral Sclerosis ALS or Fragile X Tremor Ataxia Syndrome FXTAS. Yet, many aspects of their organization as well as the specific roles of the RNA on the formation and function of these complexes are still unknown. In order to study RNP granules structu

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2

Vijayakumar, Jeshlee Cyril. "Rôle du domaine de type prion de Imp dans la régulation des granules RNP neuronaux." Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4099/document.

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Les ARNms des cellules eucaryotes sont liés à des protéines de liaison aux ARNs (RBPs) et empaquetés au sein d’assemblages macro-moléculaires appelés granules RNP. Dans les cellules neuronales, les granules RNP de transport sont impliqués dans le transport d’ARNms spécifiques jusqu’aux axones et dendrites, ainsi que dans leur traduction locale en réponse à des signaux externes. Bien que peu de choses soient connues sur l’assemblage et la régulation de ces granules in vivo, des résultats récents ont indiqué que la présence de domaines de type prion (PLDs) dans les RBPs facilite les interactions

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3

Pushpalatha, Kavya Vinayan. "Remodelage des condensats RNP neuronaux au cours du vieillissement chez la drosophile." Electronic Thesis or Diss., Université Côte d'Azur, 2021. http://theses.univ-cotedazur.fr/2021COAZ6007.

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Dans la cellule, les molécules d’ARN s’assemblent avec des protéines de liaison aux ARNs pour former des assemblages macromoléculaires très dynamiques appelés granules ribonucléoprotéiques (RNP). Ces assemblages régulent l’expression génique en contrôlant le transport, la stabilité et/ou la traduction des ARNs associés. Des travaux réalisés in vitro ont montré que la formation et la composition des granules RNP reposent sur l’établissement de réseaux denses d’interactions établis entre protéines et ARN, ainsi que sur leur stoechiométrie. Comment les propriétés des granules RNP sont régulées en

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4

Vijayakumar, Jeshlee Cyril. "Rôle du domaine de type prion de Imp dans la régulation des granules RNP neuronaux." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4099.

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Les ARNms des cellules eucaryotes sont liés à des protéines de liaison aux ARNs (RBPs) et empaquetés au sein d’assemblages macro-moléculaires appelés granules RNP. Dans les cellules neuronales, les granules RNP de transport sont impliqués dans le transport d’ARNms spécifiques jusqu’aux axones et dendrites, ainsi que dans leur traduction locale en réponse à des signaux externes. Bien que peu de choses soient connues sur l’assemblage et la régulation de ces granules in vivo, des résultats récents ont indiqué que la présence de domaines de type prion (PLDs) dans les RBPs facilite les interactions

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5

Formicola, Nadia. "Remodelage des granules ARN en réponse à l’activité neuronale." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2019. http://theses.univ-cotedazur.fr/2019AZUR6008.

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Une des questions les plus fascinantes – et les plus ouvertes – en neuroscience est de comprendre comment les cellules neuronales contribuent à la formation, le maintien puis le rappel des souvenirs. Des travaux antérieurs ont montré que la formation de la mémoire à long-terme (MLT) requiert la synthèse de novo de protéines, impliquant non seulement la traduction d’ARNs nouvellement transcrits, mais aussi la traduction locale, induite par l’expérience, d’ARNms latents transportés et stockés dans les synapses. En vue de leur transport et du contrôle de leur traduction, les ARNms sont empaquetés

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6

Shah, Khyati H. "REGULATION, COMPOSITION AND FUNCTIONS OF RNP GRANULES IN QUIESCENT CELLS OF SACCHAROMYCES CEREVISIAE." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1417541239.

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7

Agostini, Federico 1985. "Predictions of RNA-binding ability and aggregation propensity of proteins." Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/318159.

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RNA-binding proteins (RBPs) control the fate of a multitude of coding and non-coding transcripts. Formation of ribonucleoprotein (RNP) complexes fine-tunes regulation of post-transcriptional events and influences gene expression. Recently, it has been observed that non-canonical proteins with RNA-binding ability are enriched in structurally disordered and low-complexity regions that are generally involved in functional and dysfunctional associations. Therefore, it is possible that interactions with RNA protect unstructured protein domains from aberrant associations or aggregation. Nevertheless

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8

Al-Sailawi, Majid. "Investigating RNA granules formation during caliciviruses infection." Thesis, University of Surrey, 2015. http://epubs.surrey.ac.uk/809289/.

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Human norovirus (HuNV) is a member of the calicivirus family and is a major cause of viral gastroenteritis worldwide. Due to the absence of a suitable cell culture system, HuNoV replication mechanisms are poorly understood, but two animal caliciviruses, Feline calicivirus (FCV) and Murine Norovirus (MNV) provide models to increase our understanding of norovirus biology. Unlike cellular mRNAs, the calicivirus RNA genome does not possess a 5' cap structure but instead has a 13–15 kDa viral protein, genome linked (VPg) directing translation, hijacking the host protein synthesis machinery. The vir

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9

Oh, Seong-Wook. "Functional Analysis of RIG-I and RNP Complexes in the Antiviral Interferon System." 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/215973.

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10

Pizzinga, Mariavittoria. "Granules of translation factor mRNAs and their potential role in the localisation of the translation machinery to regions of polarised growth." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/granules-of-translation-factor-mrnas-and-their-potential-role-in-the-localisation-of-the-translation-machinery-to-regions-of-polarised-growth(9cb42e69-3c8c-4f10-b79f-ba8261be4430).html.

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The subcellular localisation of mRNA is a widespread mechanism to determine the fate of mRNAs in eukaryotes. Translationally repressed mRNAs localise to P-bodies and stress granules where their decay and storage, respectively, are directed. In a study from the Ashe lab, specific mRNAs were identified to localise, in actively growing S. cerevisiae, to cytoplasmic granules that do not seem to be related to P-bodies or stress granules but appear to be associated with active translation (Lui et al., 2014).It is possible that this might represent a strategy to co-regulate the expression of proteins

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11

Kuznicki, Kathleen. "The function of the germline rna helicase (GLH) genes in caenorhabditis elegans." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9988682.

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12

Lavrynenko, Kyrylo. "The interaction of Caprin1 and G3BP1, major proteins in stress granule assembly, promotes the messenger RNA recruitment by G3BP1." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL133.

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Les protéines de liaison à l'ARN (RBP) jouent un rôle majeur dans la régulation de la traduction de l'ARN messager et l'adaptation du métabolisme cellulaire à divers signaux environnementaux. La présence dans de nombreuses RBP d'une combinaison unique de domaines fonctionnels structurés et de régions intrinsèquement désordonnées, leur permet de générer des condensats riches en ARN par le processus de séparation de phase liquide-liquide. G3BP1 est une RBP centrale dans le processus de protection de l'ARNm lorsque les cellules sont exposées à des stress environnementaux via la formation des gran

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13

Chitiprolu, Maneka. "Novel Regulatory Mechanisms of Autophagy in Human Disease: Implications for the Development of Therapeutic Strategies." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38441.

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The dysfunction of autophagy pathways has been linked to the development and progression of numerous human diseases, in particular neurological disorders and cancer. Investigating these pathological autophagy mechanisms is essential to gain insights into the underlying disease mechanisms, identify novel biomarkers, and develop targeted therapies. In this thesis, I present three manuscripts that investigate the regulatory mechanisms of autophagy machinery in human diseases. In the first manuscript (Chitiprolu et al., 2018), we investigated the mechanism of p62-mediated selective autophagic cle

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14

Ferrier, Emilie. "Rôle et mode d'action de l'UTP : RNA Uridylyltransférase URT1 dans l'uridylation et la dégradation des ARNm chez Aradopsis thaliana." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ053/document.

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La dégradation des ARN est un mécanisme essentiel à la régulation de l’expression des génomes. L’importance de l’uridylation dans les mécanismes de dégradation des ARN commence juste à être appréciée. Cette thèse présente l’étudede l’UTP :RNA Uridylyltransferase 1 (URT1) et de son rôle dans la dégradation des ARN chez Arabidopsis thaliana. L’étude des propriétés catalytiques de URT1 montre que cette uridylyltransférase est intrinsèquement spécifique des UTP et distributive pour les premières uridines ajoutées. URT1 est responsable in vivo de l’uridylation des ARNm après une étape de déadénylat

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15

Findley, Seth David. "Maelstrom and Drosophila nuage /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/9255.

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16

Schreier, Juliane [Verfasser]. "Role of PKCε in RNA granule formation and protein translation / Juliane Schreier." Berlin : Freie Universität Berlin, 2013. http://d-nb.info/104162090X/34.

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17

Lockwood, Donovan Blair. "TDP-43 Modulation of PABP Positive, RNA Stress Granule Formation during Oxidative Stress." Thesis, The University of Arizona, 2015. http://hdl.handle.net/10150/579304.

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RNA dysregulation is a recently recognized disease mechanism in amyotrophic lateral sclerosis (ALS). ALS is a neurodegenerative disease characterized by muscle atrophy and death of both upper and lower motor neurons. A key feature of the disease is the mislocalization of the RNA binding protein TDP-43 and formation of TDP-43 containing cytoplasmic aggregates in motor neurons and surrounding glia. TDP-43 is known to associate with stress granules, and recent studies in mammalian cell culture have indicated that pathological TDP-43 aggregates may arise from RNA stress granules following prolonge

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18

Bahri, Alia. "Rôle des condensats préexistants dans la modulation de l'agrégation induite par le stress." Electronic Thesis or Diss., Université Côte d'Azur, 2024. http://www.theses.fr/2024COAZ6048.

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Les condensats de ribonucléoprotéines (RNP sont des organelles sans membrane concentrant des protéines et ARN spécifiques, et organisent le transcriptome et le protéome cellulaires. Une mauvaise régulation de ces condensats pourrait entraîner des maladies, lorsque ces condensats « physiologiques », normalement fluides et réversibles, deviennent des agrégats rigides et irréversibles, dits « pathologiques ». Bien que plusieurs recherches aient étudié le rôle du mauvais repliement des protéines dans cette transition, celui de l'ARN est moins exploré. Mon travail comble cette lacune en explorant l

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19

Emara, Mohamed Maged. "Analysis of the Cellular Proteins, TIA-1 and TIAR, and their Interaction with the West Nile Virus (WNV) 3' SL Minus-Strand RNA." Digital Archive @ GSU, 2007. http://digitalarchive.gsu.edu/biology_diss/70.

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The 3' terminal stem loop of the WNV minus-strand [WNV3'(-) SL] RNA was previously shown to bind the cell protein, T-cell intracellular antigen-1 (TIA-1), and the related protein, TIAR. These two proteins are known to bind AU-rich sequences in the 3' UTRs of some cellular mRNAs. AU stretches are located in three single-stranded loops (L1, L2, and L3) of the WNV3'(-) SL RNA. The RNA binding activity of both proteins was reduced when L1 or L2, but not L3, AU sequences were deleted or substituted with Cs. Deletion or substitution with Cs of the entire AU-rich sequence in either L1 or L2 in a WNV

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20

Lin, Sau-wah Selma. "A study of microRNA-132 and -212 in murine granulosa cells during folliculogenesis." Click to view the E-thesis via HKUTO, 2010. http://sunzi.lib.hku.hk/hkuto/record/B43909851.

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21

Lau, Pok, and 劉博. "MicroRNAs associated with granulin-epithelin precursor in hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206753.

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Hepatocellular carcinoma (HCC) is the major type of liver cancer. In Hong Kong, thousands of deaths are related to this disease every year. Hepatitis B virus (HBV) infection is one of the major risk factors of HCC development. The high prevalence of HBV carriers in Southeast Asia including Hong Kong can account for the particularly high HCC cases in these areas. HCC is often asymptomatic. The diagnosis and treatment are often delayed which lead to inapplicable of surgical resection. Meanwhile, conventional treatment regimes such as systemic chemotherapy were found to have limited responses.

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22

Emara, Mohamed Maged. "Analysis of the Cellular Proteins, TIA-1 and TIAR, and their Interaction with the West Nile Virus (WNV) 3' SL Minus-Strand RNA." Digital Archive @ GSU, 2008. http://digitalarchive.gsu.edu/biology_diss/38.

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The 3' terminal stem loop of the WNV minus-strand [WNV3'(-) SL] RNA was previously shown to bind the cell protein, T-cell intracellular antigen-1 (TIA-1), and the related protein, TIAR. These two proteins are known to bind AU-rich sequences in the 3' UTRs of some cellular mRNAs. AU stretches are located in three single-stranded loops (L1, L2, and L3) of the WNV3'(-) SL RNA. The RNA binding activity of both proteins was reduced when L1 or L2, but not L3, AU sequences were deleted or substituted with Cs. Deletion or substitution with Cs of the entire AU-rich sequence in either L1 or L2 in a WNV

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23

Day, Mandy Dowson. "A study of wheat endosperm development : cell and starch granule numbers and amyloplast DNA and RNA." Thesis, University of Bath, 1987. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379338.

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24

Yatsuzuka, Kenji. "Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics." Kyoto University, 2019. http://hdl.handle.net/2433/242400.

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25

Lin, Sau-wah Selma, and 林秀華. "A study of microRNA-132 and -212 in murine granulosa cells during folliculogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B43909851.

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26

Wu, Yuhong. "Structural studies of Human Caprin Protein." OpenSIUC, 2019. https://opensiuc.lib.siu.edu/dissertations/1652.

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Human Caprin-1 and Caprin-2 are prototypic members of the caprin (cytoplasmic activation/proliferation-associated protein) protein family. Vertebrate caprin proteins contain two highly conserved homologous regions (HR1 and HR2) and C-terminal RGG motifs. Drosophila caprin (dCaprin) shares HR1 and RGG motifs but lacks HR2. Caprin-1 and Caprin-2 have important and non-redundant functions. The detailed molecular mechanisms of their actions remain largely unknown.

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27

Soto-Rifo, Ricardo. "Translational control of HIV-1 and HIV-2 genomic RNA." Lyon, Ecole normale supérieure, 2010. http://www.theses.fr/2010ENSL0584.

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Les virus de la immunodéficience humaine de type 1 et 2 (VIH-1 et VIH-2) sont des pathogènes qui ont un grand impact sur la santé car plus de 33 millions de personnes sont infectées dans le monde. Les mécanismes qui contrôlent les étapes post-transcriptionelles de l’ARN génomique pendant les étapes tardives du cycle réplicatif ne sont pas très connu et donc les processus moléculaires qui permettent à l’ARN génomique de s’associer aux machineries cellulaires de traduction, transport ou dégradation restent à être déterminés. Dans ces travaux, nous avons contribué à améliorer notre connaissance s

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28

Chan, On-chim, and 陳安潛. "Characterization of microbial consortia in anaerobic granular sludge: a ribosomal RNA-based molecular approach." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31239924.

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29

De, Leeuw Frédéric. "Etude de la protéine CIRP et sa fonction dans le métabolisme des ARN messagers." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210577.

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La protéine CIRP (Cold Induced RNA binding Protein) est une petite protéine de liaison à l’ARN de 172 acides aminés, qui est constituée du côté amino-terminal d’un domaine de liaison à l’ARN de type RRM (RNA recognition motif), et d’une partie carboxy-terminale riche en glycine et arginine qui comprend plusieurs motifs RGG. Elle a été identifiée comme étant inductible par hypothermie mais aussi par irradiation aux UV et par hypoxie. Nous avons analysé son expression et sa localisation en réponse à différents stress cellulaires. Nous avons montré qu’un traitement à l’arsénite qui induit un stre

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30

Martin, Sophie. "Le composant des granules de stress G3BP : caractérisation phénotypique de souris KO, et identification de son interactome ribonucléoprotéique dans le cerveau de souris." Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20247.

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Les protéines capables de lier des ARNs sont essentielles pour les différentes étapes de maturation de l'ARN messager (ARNm), en dirigeant leur localisation et leur devenir dans la cellule, et en formant avec les ARNs des particules ribonucléoprotéiques (mRNPs). Les mRNPS peuvent former des structures cellulaires dynamiques qui sont adressées vers des fonctions spécifiques. Ces granules, tels que les granules de stress formés suite à un stress cellulaire, contiennent des ARNm dont la traduction est inhibée et qui sont stockés transitoirement. Ma thèse a consisté en la caractérisation fonctionn

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31

Orsborn, April Marie. "Analysis of interactions between the germline RNA helicases (GLHs) and their regulators KGB-1 and CSN-5 in Caenorhabditis elegans." Diss., Columbia, Mo. : University of Missouri-Columbia, 2006. http://hdl.handle.net/10355/4499.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2006.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. Includes bibliographical references.

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32

Bauer, Karl Emory [Verfasser], and Michael [Akademischer Betreuer] Kiebler. "Live microscopy of RNA granule sorting in hippocampal neurons in space and time / Karl Emory Bauer ; Betreuer: Michael Kiebler." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1196529094/34.

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Eckmann, Christian R., Mark Schmid, Adam P. Kupinski, Britta Jedamzik, Martin Harterink, and Agata Rybarska. "GLS-1, a novel P granule component, modulates a network of conserved RNA regulators to influence germ cell fate decisions." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-184095.

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Post-transcriptional regulatory mechanisms are widely used to influence cell fate decisions in germ cells, early embryos, and neurons. Many conserved cytoplasmic RNA regulatory proteins associate with each other and assemble on target mRNAs, forming ribonucleoprotein (RNP) complexes, to control the mRNAs translational output. How these RNA regulatory networks are orchestrated during development to regulate cell fate decisions remains elusive. We addressed this problem by focusing on Caenorhabditis elegans germline development, an exemplar of post-transcriptional control mechanisms. Here, we re

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Eckmann, Christian R., Mark Schmid, Adam P. Kupinski, Britta Jedamzik, Martin Harterink, and Agata Rybarska. "GLS-1, a novel P granule component, modulates a network of conserved RNA regulators to influence germ cell fate decisions." PLOS Genetics, 2009. https://tud.qucosa.de/id/qucosa%3A28993.

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Post-transcriptional regulatory mechanisms are widely used to influence cell fate decisions in germ cells, early embryos, and neurons. Many conserved cytoplasmic RNA regulatory proteins associate with each other and assemble on target mRNAs, forming ribonucleoprotein (RNP) complexes, to control the mRNAs translational output. How these RNA regulatory networks are orchestrated during development to regulate cell fate decisions remains elusive. We addressed this problem by focusing on Caenorhabditis elegans germline development, an exemplar of post-transcriptional control mechanisms. Here, we re

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35

Goulet, Isabelle. "New Roles for Arginine Methylation in RNA Metabolism and Cancer." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20293.

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Because it can expand the range of a protein’s interactions or modulate its activity, post-translational methylation of arginine residues in proteins must be duly coordinated and ‘decoded’ to ensure appropriate cellular interpretation of this biological cue. This can be achieved through modulation of the enzymatic activity/specificity of the protein arginine methyltransferases (PRMTs) and proper recognition of the methylation ‘mark’ by a subset of proteins containing ‘methyl-sensing’ protein modules known as ‘Tudor’ domains. In order to gain a better understanding of these regulatory mechanism

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36

Budkina, Karina. "The role of an mRNA-binding protein YB-1 in formation of stress granules and translation." Thesis, université Paris-Saclay, 2021. http://www.theses.fr/2021UPASL006.

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Au cours de la vie de l'ARNm dans la cellule, l'ARNm existe en complexe avec des protéines et n'est jamais libre. Dans le cytoplasme, l'ARNm actif est associé aux ribosomes pour former les polyribosomes tandis que les ARNm réprimés s’associent avec certaines protéines de liaison à l'ARN (RBP) pour former des mRNP. Les mRNP réprimés sont généralement isolés dans le cytoplasme mais ils peuvent également être trouvés dans des compartiments appelés granules d’ARN, notamment lors d'un stress cellulaire. Ces granules d’ARN sont des organelles non membranaires contenant principalement de l'ARNm inact

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Ko, Hae Kyung. "Exploring the Role of FUS Mutants from Stress Granule Incorporation to Nucleopathy in Amyotrophic Lateral Sclerosis: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/799.

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Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by preferential motor neuron death in the brain and spinal cord. The rapid disease progression results in death due to respiratory failure, typically within 3-5 years after disease onset. While ~90% of cases occur sporadically, remaining 10% of ALS cases show familial inheritance, and the number of genes linked to ALS has increased dramatically over the past decade. FUS/TLS (Fused in Sarcoma/ Translocated to liposarcoma) is a nucleic acid binding protein that may regulate several cellular functions, in

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Ko, Hae Kyung. "Exploring the Role of FUS Mutants from Stress Granule Incorporation to Nucleopathy in Amyotrophic Lateral Sclerosis: A Dissertation." eScholarship@UMMS, 2009. http://escholarship.umassmed.edu/gsbs_diss/799.

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Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by preferential motor neuron death in the brain and spinal cord. The rapid disease progression results in death due to respiratory failure, typically within 3-5 years after disease onset. While ~90% of cases occur sporadically, remaining 10% of ALS cases show familial inheritance, and the number of genes linked to ALS has increased dramatically over the past decade. FUS/TLS (Fused in Sarcoma/ Translocated to liposarcoma) is a nucleic acid binding protein that may regulate several cellular functions, in

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39

Bolinger, Cheryl Giles. "Study of translation control by a RNA helicase A-responsive post-transcriptional control element in Retroviridae." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1226513076.

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40

Palud, Amandine. "Liquid-liquid phase separation mediated by low complexity sequence domains promotes stress granule assembly and drives pathological fibrillization." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066560/document.

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Il a été observé que l’altération des fonctions des granules de stress, entités cytoplasmiques non-membranaires composées d’ARN et de protéines liant l’ARN (RBPs), peut conduire au développement de maladies telles que la sclérose latérale amyotrophique, la démence fronto-temporale, la myopathie à inclusions et la maladie de Paget des os. Ces pathologies sont caractérisées par un dépôt cytoplasmique d’inclusions solides enrichies en RBPs et comprenant des fibrilles. Une connexion génétique a été suggérée entre la persistance des granules de stress et l’accumulation de ces inclusions pathologiqu

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41

Twyffels, Laure. "Nucleo-cytoplasmic transport of TIS11 proteins and stress granule assembly: two potential new roles for Transportins." Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209423.

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The nucleo-cytoplasmic compartmentalization enables eukaryotic cells to develop sophisticated post-transcriptional regulations of gene expression. However, managing the exchanges of macromolecules between the two compartments also represents a formidable challenge for the cells. Nucleo-cytoplasmic exchanges rely on specialized soluble carriers and take place at nuclear pore complexes that span the nuclear envelope. Active nucleo-cytoplasmic transport of proteins, in particular, is performed mainly by a family of carriers called karyopherins, which includes about twenty members in mammals. Some

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Bonnet, Agnès. "Étude de l'expression des gènes au cours des stades précoces de la folliculogenèse ovarienne chez les mammifères de rente (brebis)." Toulouse 3, 2013. http://thesesups.ups-tlse.fr/2306/.

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Le bon déroulement de la folliculogenèse ovarienne basale, est une étape clé qui conditionne la fertilité des femelles à l'âge adulte. Pourtant, les mécanismes moléculaires contrôlant ce processus sont encore mal connus et les études d'expression limitées par la difficulté d'obtention du matériel biologique. Les données actuelles proviennent essentiellement d'études réalisées chez les rongeurs (espèces poly-ovulantes). L'objectif de ce travail est de décrire, pour les deux compartiments folliculaires (ovocytes et cellules de granulosa), les spécificités d'expression et les gènes impliqués dans

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Tréol, Cyriaque. "Vers une modélisation du comportement d'un lit de débris sur le récupérateur de corium d'un RNR-Na." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPAST016.

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Ce sujet de thèse concerne les accidents graves dans un Réacteur à Neutrons Rapides refroidi au Sodium (RNR-Na). Le terme accident grave désigne les accidents nucléaires avec fusion partielle ou totale du cœur, qui forme un mélange de matériaux fondus appelé corium. De tels accidents se sont produits par le passé dans des réacteurs nucléaires de filières différentes : l'accident de Three Mile Island en 1979 sur un Réacteur à Eau Pressurisée, celui de Tchernobyl en 1986 sur un réacteur de type RBMK, et les accidents de Fukushima en 2011 sur des Réacteurs à Eau Bouillante. Ces catastrophes, bien

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Kaushansky, Laura J. "Investigating the Effects of Mutant FUS on Stress Response in Amyotrophic Lateral Sclerosis: A Thesis." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/792.

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During stress, eukaryotes regulate protein synthesis in part through formation of cytoplasmic, non-membrane-bound complexes called stress granules (SGs). SGs transiently store signaling proteins and stalled translational complexes in response to stress stimuli (e.g. oxidative insult, DNA damage, temperature shifts and ER dysfunction). The functional outcome of SGs is proper translational regulation and signaling, allowing cells to overcome stress. The fatal motor neuron disease Amyotrophic Lateral Sclerosis (ALS) develops in an age-related manner and is marked by progressive neuronal death, wi

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Kaushansky, Laura J. "Investigating the Effects of Mutant FUS on Stress Response in Amyotrophic Lateral Sclerosis: A Thesis." eScholarship@UMMS, 2008. http://escholarship.umassmed.edu/gsbs_diss/792.

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During stress, eukaryotes regulate protein synthesis in part through formation of cytoplasmic, non-membrane-bound complexes called stress granules (SGs). SGs transiently store signaling proteins and stalled translational complexes in response to stress stimuli (e.g. oxidative insult, DNA damage, temperature shifts and ER dysfunction). The functional outcome of SGs is proper translational regulation and signaling, allowing cells to overcome stress. The fatal motor neuron disease Amyotrophic Lateral Sclerosis (ALS) develops in an age-related manner and is marked by progressive neuronal death, wi

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Leplus, Alexis. "Study of factors implicated in small ribosomal subunit biogenesis under differents growth conditions." Doctoral thesis, Universite Libre de Bruxelles, 2010. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210189.

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La biogenèse du ribosome est un processus complexe et dynamique qui nécessite de nombreuses étapes de maturation et de modification des ARNr ainsi que l’assemblage et le transport des RNPs précurseurs. Un ribosome mature contient une centaine de pièces, ARN et protéines confondus, mais son assemblage requiert l’intervention de plus de 400 facteurs de synthèse. De part le coût énergétique important de ce processus, plusieurs voies de régulation interviennent pour contrôler la biogenèse des ribosomes en fonction des conditions nutritives. L’une des voies les plus connue est la voie TOR (Target o

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Vautrot, Valentin. "Recherche des mécanismes impliqués dans les dérégulations de l'épissage alternatif à l'origine de la progéria et étude du rôle de l'étape d'épissage dans les changements globaux d'expression des gènes en réaction au choc thermique." Thesis, Université de Lorraine, 2013. http://www.theses.fr/2013LORR0321/document.

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Le syndrome de Hutchinson-Gilford, ou progéria, est une pathologie génétique rare qui se caractérise par des symptômes assimilés à un vieillissement prématuré. Les mutations à l'origine de la progéria affectent le gène LMNA, codant la lamine A, qui joue un rôle majeur dans la formation, la maintenance et la résistance du noyau. Ces mutations activent l'utilisation de sites 5' alternatif ou cryptique d'épissage présents dans l'exon 11 du pré-ARNm LMNA en amont du site normalement utilisé. Nous avons révélé un effet des mutations sur la structure secondaire de l'ARN aux alentours des mutations,

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Pattabiraman, Sundararaghavan. "Vimentin protects differentiating stem cells from stress." Doctoral thesis, 2019. http://hdl.handle.net/21.11130/00-1735-0000-0005-151B-6.

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Hrbková, Pavlína. "Lidské proteiny z rodiny 4E ve stresových granulích a jejich další charakterizace." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-380436.

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Eukaryotic initiation factor 4E (eIF4E) is a key part of initiation and regulation of translation in human cells. Three members of human eIF4E proteins have been characterized: eIF4E1, eIF4E2 and eIF4E3. Cellular stress causes translation initiation inhibition followed by disassembly of the polysomes, those processes are accompanied by the assembly of cytoplasmic RNA granules, called stress granules (SG). Stress granules are dynamic structures whose composition may vary depending on the cell type and the stress stimulus. In this study, human cells were subjected to the following stress conditi

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Chang, Wei-Lun, and 張瑋倫. "Characterization of the role of transportin in cytoplasmic RNA granules." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/40375101175145495591.

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博士<br>國防醫學院<br>生命科學研究所<br>98<br>The distribution of proteins is likely to change in response to cellular stresses triggered signaling pathways. Since importin-beta family members are essential for nucleocytoplasmic transport of macromolecules, we attempted to explore whether importin-beta family proteins change their cellular localization in response to environmental change. Among the importin-beta members we analyzed, only transportin (TRN) was shown to detect in a subset of cytoplasmic processing bodies (P-bodies) under normal cell conditions and apparently translocate to stress granules (SG

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