Log in

Relevant bibliographies by topics / Granuloma / Journal articles

To see the other types of publications on this topic, follow the link: Granuloma.

Journal articles on the topic 'Granuloma'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Granuloma.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Mattila, Joshua T., Victoria A. Gould, Beth A. Junecko, et al. "Bacteria load and hypoxia contribute to glucose uptake by macrophages and T cells in cynomolgus macaque granulomas." Journal of Immunology 208, no. 1_Supplement (2022): 50.22. http://dx.doi.org/10.4049/jimmunol.208.supp.50.22.

Full text

Abstract:

Abstract Granulomas form during tuberculosis (TB) and restrain bacterial dissemination but are also sites of mycobacterial replication and persistence. The immunometabolic state of cells in granulomas has immunologic and diagnostic relevance and PET-CT with the glucose analog FDG demonstrates that granuloma glucose uptake is dynamic and heterogenous within a host. Basic details on glucose uptake, including the cells responsible for FDG PET signal, have not been resolved and filling these gaps will improve interpretation of PET data in TB. Our objective was to identify relationships between glu

APA, Harvard, Vancouver, ISO, and other styles

2

Cardoso, Marcos S., Tânia M. Silva, Mariana Resende, Rui Appelberg та Margarida Borges. "Lack of the Transcription Factor Hypoxia-Inducible Factor 1α (HIF-1α) in Macrophages Accelerates the Necrosis of Mycobacterium avium-Induced Granulomas". Infection and Immunity 83, № 9 (2015): 3534–44. http://dx.doi.org/10.1128/iai.00144-15.

Full text

Abstract:

The establishment of mycobacterial infection is characterized by the formation of granulomas, which are well-organized aggregates of immune cells, namely, infected macrophages. The granuloma's main function is to constrain and prevent dissemination of the mycobacteria while focusing the immune response to a limited area. In some cases these lesions can grow progressively into large granulomas which can undergo central necrosis, thereby leading to their caseation. Macrophages are the most abundant cells present in the granuloma and are known to adapt under hypoxic conditions in order to avoid c

APA, Harvard, Vancouver, ISO, and other styles

3

Hogan, Laura H., Wes Markofski, Anja Bock, Brittany Barger, James D. Morrissey, and Matyas Sandor. "Mycobacterium bovis BCG-Induced Granuloma Formation Depends on Gamma Interferon and CD40 Ligand but Does Not Require CD28." Infection and Immunity 69, no. 4 (2001): 2596–603. http://dx.doi.org/10.1128/iai.69.4.2596-2603.2001.

Full text

Abstract:

ABSTRACT Progressive granuloma formation is a hallmark of chronic mycobacterial infection. Granulomas are localized, protective inflammatory reactions initiated by CD4+ T cells, which contribute to control of bacterial growth and blockade of bacterial dissemination. In order to understand the costimulatory requirements that allow CD4+ T cells to directly or indirectly induce granulomas, we studied granuloma formation after 6 weeks inMycobacterium bovis BCG-infected CD28- and CD40 ligand (CD40L)-deficient mice and compared it to granuloma formation in infected wild-type inbred mice and infected

APA, Harvard, Vancouver, ISO, and other styles

4

Rumbley, Catherine A., S. Ali Zekavat, Hiroko Sugaya, Peter J. Perrin, Mohamad Ali Ramadan, and S. Michael Phillips. "The Schistosome Granuloma: Characterization of Lymphocyte Migration, Activation, and Cytokine Production." Journal of Immunology 161, no. 8 (1998): 4129–37. http://dx.doi.org/10.4049/jimmunol.161.8.4129.

Full text

Abstract:

Abstract Granuloma formation and its regulation are dependent on lymphocytes. Therefore, we compared the characteristics of lymphocytes derived from the spleens and granulomas of Schistosoma mansoni-infected mice during the course of their disease. We examined lymphocyte cell cycle kinetics, migration, expression of activation Ags (CD69 and IL-2R), cytokine production (IL-2, IL-4, IFN-γ), and apoptosis. Lymphocytes in the G2/M phase of the cell cycle and high levels of lymphocyte intracellular IL-2 were found in the spleen but not in the granuloma. Cell trafficking experiments showed Ag-specif

APA, Harvard, Vancouver, ISO, and other styles

5

Fitzgerald, Liam E., Naiara Abendaño, Ramon A. Juste, and Marta Alonso-Hearn. "Three-DimensionalIn VitroModels of Granuloma to Study Bacteria-Host Interactions, Drug-Susceptibility, and Resuscitation of Dormant Mycobacteria." BioMed Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/623856.

Full text

Abstract:

Mycobacterium tuberculosis,Mycobacterium leprae,Mycobacterium bovis,andMycobacterium aviumsubsp.paratuberculosiscan survive within host macrophages in a dormant state, encased within an organized aggregate of immune host cells called granuloma. Granulomas consist of uninfected macrophages, foamy macrophages, epithelioid cells, and T lymphocytes accumulated around infected macrophages. Within granulomas, activated macrophages can fuse to form multinucleated giant cells, also called giant Langhans cells. A rim of T lymphocytes surrounds the core, and a tight coat of fibroblast closes the structu

APA, Harvard, Vancouver, ISO, and other styles

6

Herbath, Melinda, Jeffrey S. Harding, Sarah Marcus, et al. "Regulators of mycobacterial granuloma formation – CCL2 and VEGF-A." Journal of Immunology 200, no. 1_Supplement (2018): 42.7. http://dx.doi.org/10.4049/jimmunol.200.supp.42.7.

Full text

Abstract:

Abstract Granulomas are macrophage dominated lesions and are a central feature of mycobacterial infections. These cell aggregates are dynamically changing structures as the life span of the granuloma recruited effector cells is relatively short and the cells have to be replaced. CCL2 and VEGF-A are required for granuloma maintenance as blocking the action of these chemokines results in reduction of granuloma size and number after BCG or Mtb infections. We seek to elucidate the relevance of these two cytokines in the timeline of mycobacterial infections and their relative contribution to granul

APA, Harvard, Vancouver, ISO, and other styles

7

Dhakal, Mona, Om Prakash Dhakal, Mingma Sherpa, Amlan Gupta, and Dhurba Bhandari. "Large gastric ulcer: Result of foreign body-induced giant cell reaction." Journal of Digestive Endoscopy 04, no. 03 (2013): 078–81. http://dx.doi.org/10.4103/0976-5042.129974.

Full text

Abstract:

AbstractA granuloma is an organized and compact mass of mature mononuclear phagocytes. Granulomas are reported to form in various organs and sites of the body. Granulomas in stomach are rarely encountered. Foreign body granulomas are formed as a result of reaction of the tissues to a foreign body which is immunologically inert. Food granuloma is type of foreign body granuloma which is formed in response to food particles like vegetable matters or cereals. These granulomas can be distinguished from other types of granulomas with ease because of their characteristic morphologic features. We repo

APA, Harvard, Vancouver, ISO, and other styles

8

Metwali, A., D. Elliott, R. Mathew, A. Blum, and J. V. Weinstock. "IL-2 contributes to the IL-5 response in granulomas from mice infected with Schistosoma mansoni." Journal of Immunology 150, no. 2 (1993): 536–42. http://dx.doi.org/10.4049/jimmunol.150.2.536.

Full text

Abstract:

Abstract Th cells within the granulomas of murine schistosomiasis mansoni produce IL-5, which is essential for granuloma eosinophil growth and development. The mechanisms regulating granuloma IL-5 production are unknown. The granulomas also make IL-2 in small quantities. rIL-2 therapy stimulates eosinophilia and IL-5 synthesis. Therefore, we studied the effect of IL-2 on IL-5 production within the liver granulomas of murine Schistosoma mansoni. Dispersed granuloma cells and intact granulomas cultured in vitro released IL-5. Adding anti-IL-2 or anti-IL-2R to the cultures, to block IL-2 activity

APA, Harvard, Vancouver, ISO, and other styles

9

Patel, Kinari X. "Granulomatous Manifestations Associated with Animals and a Novel Potential Zoonotic Infection from Elephant Washing." Medical & Clinical Research 9, no. 10 (2024): 01–04. http://dx.doi.org/10.33140/mcr.09.10.03.

Full text

Abstract:

Zoonotic infections are group of contagions that are transmitted from animals to humans. These are acquired from domestic and wild animals by different routes. Presentation can vary between systemic and cutaneous manifestation. A granuloma is a skin manifestation, that is named due to its appearance under a microscope. A wide range of skin pathologies exist, where granulomas are a prominent feature of their presentation. We report a case of a patient who presented with a solitary lesion on her hand, reminiscent of granulomata, following a trip to India where she was involved in washing elephan

APA, Harvard, Vancouver, ISO, and other styles

10

Talita Shofa Adestia. "In vitro Tuberculosis Granuloma Model in M. tuberculosis H37Rv." Jurnal Biosains Pascasarjana 25, no. 1 (2023): 66–73. http://dx.doi.org/10.20473/jbp.v25i1.2023.66-73.

Full text

Abstract:

M. tuberculosis is a bacterium that has many evasion mechanisms against the immune system, one of them is the formation of granulomas which is beneficial for the bacteria’s survival. The granuloma structure is useful for limiting the spread of M. tuberculosis and localizing infection, also considered as part of M. tuberculosis life cycle that successful fighting the body's immune system. This study aims to look at the formation of an in vitro tuberculous granuloma model. This study used the True Experiment type which began with blood sampling, PBMC isolation, macrophage isolation, MOI 10 makin

APA, Harvard, Vancouver, ISO, and other styles

11

Rakasz, Eva, Arthur M. Blum, Ahmed Metwali та ін. "Localization and Regulation of IFN-γ Production Within the Granulomas of Murine Schistosomiasis in IL-4-Deficient and Control Mice". Journal of Immunology 160, № 10 (1998): 4994–99. http://dx.doi.org/10.4049/jimmunol.160.10.4994.

Full text

Abstract:

Abstract Schistosome granulomas from normal or IL-4-deficient C57BL/6 mice make little IFN-γ and show no Th1 polarization. This could signify that these granulomas have few cells capable of IFN-γ synthesis or that such cells are under tight control. Granulomas can make IL-10 and TGF-β, which can regulate IFN-γ synthesis. Using FACS analysis and ELISA, we explored the origin and regulation of IFN-γ in schistosome granulomas from both IL-4−/− and IL-4+/+ mice. FACS analysis of intracytoplasmic IFN-γ staining showed that some granuloma Thy1.2+ T cells (CD8+ and CD4+) express IFN-γ. Granulomas had

APA, Harvard, Vancouver, ISO, and other styles

12

Farwell, D. G., P. C. Belafsky, and C. J. Rees. "An endoscopic grading system for vocal process granuloma." Journal of Laryngology & Otology 122, no. 10 (2008): 1092–95. http://dx.doi.org/10.1017/s0022215108001722.

Full text

Abstract:

AbstractBackground:A reliable grading system allows the clinician to classify disease severity, monitor progress and evaluate treatment efficacy. There is no currently accepted grading system for vocal process granuloma of the larynx.Aim:To evaluate the reliability of a new grading system for vocal process granuloma.Methods:All vocal process granuloma images from a digital laryngeal image library were abstracted. Granulomas were graded on a one to four system, as follows: grade one, sessile, non-ulcerative granuloma limited to vocal process; grade two, pedunculated or ulcerated granuloma limit

APA, Harvard, Vancouver, ISO, and other styles

13

Volkman, Hannah E., Tamara Pozos, John Zheng, John F. Rawls, and Lalita Ramakrishnan. "The Mycobacterium marinum RD1 locus promotes virulence and macrophage aggregation into tuberculous granulomas by enhancing induction of host matrix metalloproteinase 9 in proximal epithelial cells (133.19)." Journal of Immunology 182, no. 1_Supplement (2009): 133.19. http://dx.doi.org/10.4049/jimmunol.182.supp.133.19.

Full text

Abstract:

Abstract Granulomas are organized aggregates of differentiated macrophages and other immune cells that form in response to mycobacterial infection and other persistent stimuli. While the tuberculous granuloma has long been considered a host-protective structure, our recent work in the genetically tractable and optically transparent zebrafish embryo-Mycobacterium marinum model of tuberculosis, has suggested that the early granuloma actually benefits mycobacteria. The mycobacterial RD1 virulence locus, a specialized bacterial secretion system, enhances granuloma formation, which in turn, promote

APA, Harvard, Vancouver, ISO, and other styles

14

Herbath, Melinda, Jeffrey S. Harding, György Haskó, András Nagy, Zsuzsanna Fábry, and Mátyás Sándor. "Recruitment of myeloid cells into mycobacterial granulomas." Journal of Immunology 196, no. 1_Supplement (2016): 65.18. http://dx.doi.org/10.4049/jimmunol.196.supp.65.18.

Full text

Abstract:

Abstract Granuloma formation is a hallmark of mycobacterial infection. The dominant cell types in granuloma are the blood monocyte derived macrophages and inflammatory dendritic cells that represent up to 80% of cells in these lesions. Using granuloma transplantation we demonstrated that in a week more than the third of these cells are replaced. Innate and cognate immunity against the bacteria induces a battery of chemokines that are important in this recruitment and MCP1-CCR2 is one of the main representatives of these pathways. We have also shown that cell death and death-induced extracellul

APA, Harvard, Vancouver, ISO, and other styles

15

Metwali, Ahmed, Arthur Blum, David E. Elliott та Joel V. Weinstock. "Interleukin-4 Receptor α Chain and STAT6 Signaling Inhibit Gamma Interferon but Not Th2 Cytokine Expression within Schistosome Granulomas". Infection and Immunity 70, № 10 (2002): 5651–58. http://dx.doi.org/10.1128/iai.70.10.5651-5658.2002.

Full text

Abstract:

ABSTRACT Compared to wild-type (WT) mice, schistosome granulomas in Stat6 knockout (KO) mice lacked eosinophils and had Th1 features. Interleukin-4 (IL-4) acts through Stat6 in assisting Th2 cell development. The importance of Stat6 for Th2-cell development within schistosome granulomas had not been explored. Therefore we studied gamma interferon (IFN-γ), IL-4, and IL-5 production in granulomas from Stat6 KO and WT mice. Dispersed granuloma cells from Stat6 KO and WT mice made similar amounts of IL-4 and IL-5. Only Stat6 KO granuloma cells released IFN-γ. Granuloma T cells contained most of th

APA, Harvard, Vancouver, ISO, and other styles

16

Taniguchi, Kazuto, Kazutaka Mizuta, and Kazuyasu Uemichi. "A Novel Strategy for Umbilical Granuloma Removal: Cutting off with a Nylon Suture Thread." Journal of Nepal Paediatric Society 42, no. 3 (2022): 67–69. http://dx.doi.org/10.3126/jnps.v42i3.45499.

Full text

Abstract:

Umbilical granuloma is a common umbilical problem in infants. Although various modalities are available for the treatment of umbilical granulomas, the best method remains controversial. A 7-week-old infant presented with umbilical granuloma followed by omphalitis. We treated the omphalitis first to prevent local inflammation. On the following day, the umbilical granuloma was successfully cut off with a nylon suture thread. No residue of the granuloma was left behind and no signs of local inflammation appeared. Umbilical granuloma can be successfully removed with a nylon suture thread. Treatmen

APA, Harvard, Vancouver, ISO, and other styles

17

Elliott, D. E., A. Metwali, A. M. Blum, M. Sandor, R. Lynch, and J. V. Weinstock. "T lymphocytes isolated from the hepatic granulomas of schistosome-infected mice express somatostatin receptor subtype II (SSTR2) messenger RNA." Journal of Immunology 153, no. 3 (1994): 1180–86. http://dx.doi.org/10.4049/jimmunol.153.3.1180.

Full text

Abstract:

Abstract Schistosomiasis mansoni is a disease characterized by liver and intestinal granulomas. Previous investigations in our laboratory showed that nylon wool-adherent CD4+ T lymphocytes isolated from murine hepatic schistosome granulomas express receptors for somatostatin 1-14. Moreover, somatostatin 1-14 substantially decreased IFN-gamma and IgG2a, but not IL-5 secretion by dispersed granuloma cells. This paper extends these observations by defining the somatostatin receptor (SSTR) isoform most likely expressed by granuloma inflammatory lymphocytes. Amplification of mRNA by reverse transcr

APA, Harvard, Vancouver, ISO, and other styles

18

Huang, Suyue, Maoying Liu, Hui Zhang, et al. "HIV-MTB Co-Infection Reduces CD4+ T Cells and Affects Granuloma Integrity." Viruses 16, no. 8 (2024): 1335. http://dx.doi.org/10.3390/v16081335.

Full text

Abstract:

Granuloma is a crucial pathological feature of tuberculosis (TB). The relationship between CD4+ T cells in both peripheral blood and granulomatous tissue, and the integrity of granulomas in Human Immunodeficiency Virus (HIV)–MTB co-infection, remains unexplored. This study collected biopsy specimens from 102 TB patients (53 with HIV-MTB co-infection and 49 only with TB). Hematoxylin and eosin (HE) staining and immunohistochemical staining were performed, followed by microscopic examination of the integrity of tuberculous granulomas. Through statistical analysis of peripheral blood CD4+ T cell

APA, Harvard, Vancouver, ISO, and other styles

19

Dykstra, M. J., and E. J. Noga. "A light and electron microscopic examination of novel features of fish granulomas." Proceedings, annual meeting, Electron Microscopy Society of America 45 (August 1987): 862–63. http://dx.doi.org/10.1017/s0424820100128596.

Full text

Abstract:

A typical mammalian granuloma resulting from chronic inflammation is primarily composed of plasma cells, lymphocytes, macrophages, monocytes and giant cells. So-called epithelioid cells are usually found in granulomas of immunological origin and are derived from the mononuclear phagocyte series. Epithelioid cell granulomas are associated with a number of infectious diseases of man such as tuberculosis, schistosomiasis and fungal infections such as coccidioidomycosis.Tissues from Atlantic menhaden and Tilapia fish were fixed in 10% formalin and stained with hematoxylin and eosin (H&E) for l

APA, Harvard, Vancouver, ISO, and other styles

20

Kobayashi, K., C. Allred, and T. Yoshida. "Mechanisms of suppressed cell-mediated immunity and impaired antigen-induced interleukin 2 production in granuloma-bearing mice." Journal of Immunology 135, no. 5 (1985): 2996–3003. http://dx.doi.org/10.4049/jimmunol.135.5.2996.

Full text

Abstract:

Abstract Pulmonary granulomas were induced in BALB/c mice immunized with methylated bovine serum albumin in complete Freund's adjuvant by the intratracheal injection of plain agarose beads or beads conjugated to specific antigen. Large hypersensitivity granulomas developed around antigen-coupled beads in immunized animals. Smaller but still prominent granulomatous reactions developed around plain beads in immunized mice. In nonimmunized animals, both plain and antigen conjugated beads produced very small granulomas. Granuloma formation in sensitized animals was associated with suppressed delay

APA, Harvard, Vancouver, ISO, and other styles

21

Marino, Simeone, Nicholas Cilfone, Joshua Mattila, JoAnne Flynn, Jennifer Linderman, and Denise Kirschner. "Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection (IRC5P.475)." Journal of Immunology 192, no. 1_Supplement (2014): 125.24. http://dx.doi.org/10.4049/jimmunol.192.supp.125.24.

Full text

Abstract:

Abstract Lung granulomas are the pathologic hallmark of tuberculosis (TB), where different immune cell types and bacteria co-localize. Macrophages are the most abundant cells in a granuloma. They are both critical effector and target cells for Mycobacterium tuberculosis (Mtb, the causative agent of TB) infection, and serve as regulators of inflammation and innate immune responses by producing a variety of pro- and anti-inflammatory cytokines. Overall, macrophage function, diversity and location within a granuloma environment are still poorly understood. In this study we used a systems biology

APA, Harvard, Vancouver, ISO, and other styles

22

Lukacs, N. W., S. L. Kunkel, R. M. Strieter, K. Warmington, and S. W. Chensue. "The role of macrophage inflammatory protein 1 alpha in Schistosoma mansoni egg-induced granulomatous inflammation." Journal of Experimental Medicine 177, no. 6 (1993): 1551–59. http://dx.doi.org/10.1084/jem.177.6.1551.

Full text

Abstract:

Macrophage inflammatory protein 1 alpha (MIP-1 alpha) is a 6-8-kD, lipopolysaccharide-inducible monocyte and neutrophil chemotactic protein that may be important in acute and chronic inflammation. The present study determined the sequential production, source, and in vivo contribution of murine MIP-1 alpha in synchronized Schistosoma mansoni egg pulmonary granuloma formation. Granulomas were examined under conditions of primary, secondary vigorous, and secondary immunomodulated immunity. Secreted MIP-1 alpha was measured in 24-h supernatants from intact granulomas (700/ml) cultured with or wit

APA, Harvard, Vancouver, ISO, and other styles

23

Lins, Romero Antunes Barreto, Carmelita Bezerra de Lima Cavalcanti, Jorge Luiz Silva Araújo-Filho, Mário Ribeiro de Melo-Júnior, and Maria Elizabeth Cavalcante Chaves. "A distribuição dos eosinófilos nas diferentes fases de evolução do granuloma hepático em camundongos infectados pelo Schistosoma mansoni." Revista da Sociedade Brasileira de Medicina Tropical 41, no. 2 (2008): 173–78. http://dx.doi.org/10.1590/s0037-86822008000200008.

Full text

Abstract:

No presente estudo, avaliou-se a distribuição dos eosinófilos nas diferentes fases da formação do granuloma hepático de camundongos infectados pelo Schistosoma mansoni. A partir dos resultados obtidos sugerimos uma nova classificação para a evolução do granuloma hepático em camundongos montada a partir de fases descritas por outros autores. Em cada fase há um padrão diferente de distribuição dos eosinófilos. Na fase necrótico-exudativa os eosinófilos encontram-se concentrados na periferia e no centro do granuloma e na área de necrose eles são escassos; na "produtiva" os eosinófilos estão ainda

APA, Harvard, Vancouver, ISO, and other styles

24

Nakamizo, Satoshi, Yuki Sugiura, Yoshihiro Ishida, Gyohei Egawa, and Kenji Kabashima. "Essential Role of the Pentose Phosphate Pathway Activation in Macrophages for Granuloma Formation in Sarcoidosis." Journal of Immunology 212, no. 1_Supplement (2024): 1137_4395. http://dx.doi.org/10.4049/jimmunol.212.supp.1137.4395.

Full text

Abstract:

Abstract Sarcoidosis is a disease of unknown cause that forms granulomas in various organs, has no specific treatment established. Here, we investigated the mechanism of granuloma formation by applying single-cell RNA sequencing to skin biopsy specimens from human patients with sarcoidosis. In cutaneous sarcoidosis granuloma lesions, there was an increase in macrophages expressing angiotensin-converting enzyme (ACE) and lysozyme, which are known to be elevated in the serum of sarcoidosis patients. These macrophages were hypermetabolic, especially in the pentose phosphate pathway (PPP). Immunos

APA, Harvard, Vancouver, ISO, and other styles

25

Evans, Stephanie, J. Russell Butler, Joshua T. Mattila, and Denise E. Kirschner. "Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation." PLOS Computational Biology 16, no. 12 (2020): e1008520. http://dx.doi.org/10.1371/journal.pcbi.1008520.

Full text

Abstract:

Mycobacterium tuberculosis (Mtb) infection causes tuberculosis (TB), a disease characterized by development of granulomas. Granulomas consist of activated immune cells that cluster together to limit bacterial growth and restrict dissemination. Control of the TB epidemic has been limited by lengthy drug regimens, antibiotic resistance, and lack of a robustly efficacious vaccine. Fibrosis commonly occurs during treatment and is associated with both positive and negative disease outcomes in TB but little is known about the processes that initiate fibrosis in granulomas. Human and nonhuman primate

APA, Harvard, Vancouver, ISO, and other styles

26

Penar, Paul L., Jung Kim, Douglas Chyatte, and James K. Sabshin. "Intraventricular cryptococcal granuloma." Journal of Neurosurgery 68, no. 1 (1988): 145–48. http://dx.doi.org/10.3171/jns.1988.68.1.0145.

Full text

Abstract:

✓ Infection by Cryptococcus neoformans, a budding nonmycelial yeast, involves the central nervous system in 70% of patients at the time of diagnosis. Meningitis and meningoencephalitis are common manifestations of infection; solid granulomas occur but are unusual, and intraventricular granulomas are distinctly rare. Two cases of intraventricular cryptococcal granuloma are reported. The diagnosis and treatment of mass lesions due to cryptococcal infection are discussed, with special reference to intraventricular granulomas.

APA, Harvard, Vancouver, ISO, and other styles

27

Ogburn, David, Sophia Bhalla, Nan Leffler, et al. "The M2a Macrophage Phenotype Accompanies Pulmonary Granuloma Resolution in Mmp12 Knock-Out Mice Instilled with Multiwall Carbon Nanotubes." International Journal of Molecular Sciences 22, no. 20 (2021): 11019. http://dx.doi.org/10.3390/ijms222011019.

Full text

Abstract:

Sarcoidosis is a chronic disease with unknown etiology and pathophysiology, characterized by granuloma formation. Matrix Metalloproteinase-12 (MMP12) is an elastase implicated in active granulomatous sarcoidosis. Previously, we reported that oropharyngeal instillation of multiwall carbon nanotubes (MWCNT) into C57Bl/6 mice induced sarcoid-like granulomas and upregulation of MMP12. When Mmp12 knock-out (KO) mice were instilled with MWCNT, granuloma formation occurred 10 days post-instillation but subsequently resolved at 60 days. Thus, we concluded that MMP12 was essential to granuloma persiste

APA, Harvard, Vancouver, ISO, and other styles

28

Blum, Arthur M., Ahmed Metwali, Mindy Kim-Miller, et al. "The Substance P Receptor Is Necessary for a Normal Granulomatous Response in Murine Schistosomiasis Mansoni." Journal of Immunology 162, no. 10 (1999): 6080–85. http://dx.doi.org/10.4049/jimmunol.162.10.6080.

Full text

Abstract:

Abstract Immune cells within the granulomas of murine schistosomiasis mansoni make the neuropeptide substance P (SP) and express neurokine 1 receptor, which is the specific receptor for substance P (SPr). It was determined if mice with deletion of the SPr (SPr−/−) would develop a normal granulomatous response to schistosome ova during the course of natural infection. Mean liver granuloma size was smaller in SPr−/− mice compared with that of wild-type control animals. Although flow analysis revealed little difference in the cellular composition of the granulomas, both splenocytes and granuloma

APA, Harvard, Vancouver, ISO, and other styles

29

Marino, Simeone, Nicholas A. Cilfone, Joshua T. Mattila, Jennifer J. Linderman, JoAnne L. Flynn, and Denise E. Kirschner. "Macrophage Polarization Drives Granuloma Outcome during Mycobacterium tuberculosis Infection." Infection and Immunity 83, no. 1 (2014): 324–38. http://dx.doi.org/10.1128/iai.02494-14.

Full text

Abstract:

Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), induces formation of granulomas, structures in which immune cells and bacteria colocalize. Macrophages are among the most abundant cell types in granulomas and have been shown to serve as both critical bactericidal cells and targets forM. tuberculosisinfection and proliferation throughout the course of infection. Very little is known about how these processes are regulated, what controls macrophage microenvironment-specific polarization and plasticity, or why some granulomas control bacteria and others permit bacterial disse

APA, Harvard, Vancouver, ISO, and other styles

30

Evans, Stephanie, Eileen A. Wong, JoAnne L. Flynn, Joshua T. Mattila, and Denise Kirschner. "Unraveling the role of fibrosis in the TB Granuloma." Journal of Immunology 202, no. 1_Supplement (2019): 182.86. http://dx.doi.org/10.4049/jimmunol.202.supp.182.86.

Full text

Abstract:

Abstract Tuberculosis (TB), a deadly infectious disease caused by the bacterium Mycobacterium tuberculosis (Mtb). The disease is characterized by the development of granulomas consisting of immune cells that form a cluster around the bacteria to limit bacterial growth and disease outcomes. Control of the TB epidemic is limited by a complicated drug regimen, development of antibiotic resistance, and the lack of an effective vaccine against infection and disease. Fibrosis is common in older granulomas, and has been associated with both positive and negative disease outcomes. Little is known abou

APA, Harvard, Vancouver, ISO, and other styles

31

Jusuf Fantoni, Odelia Jovita, Inda Astri Aryani, Yuli Kurniawati, and Raden Pamudji. "Histopathological Features of Cutaneous Tuberculoid Granuloma Disorders." Bioscientia Medicina : Journal of Biomedicine and Translational Research 5, no. 9 (2021): 825–36. http://dx.doi.org/10.32539/bsm.v5i9.347.

Full text

Abstract:

Tuberculoid granulomas consist of epithelioid histiocytes, Langhans giant cells and rarely foreign bodies with lymphocytes, plasma cells and caseous necrosis. The granulomatous reaction pattern is defined as a typical inflammatory pattern that is characterized by granulomas. Various etiologies can lead to granulomatous reactions. The histopathological features of cutaneous disorders with tuberculoid granuloma include cutaneous tuberculosis, tuberculids, Morbus Hansen, syphilis and rosacea. There are various clinical manifestations of tuberculoid granuloma with similar appearances which makes i

APA, Harvard, Vancouver, ISO, and other styles

32

Jusuf Fantoni, Odelia Jovita, Inda Astri Aryani, Yuli Kurniawati, and Raden Pamudji. "Histopathological Features of Cutaneous Tuberculoid Granuloma Disorders." Bioscientia Medicina : Journal of Biomedicine and Translational Research 5, no. 3 (2021): 797–808. http://dx.doi.org/10.32539/bsm.v5i3.347.

Full text

Abstract:

Tuberculoid granulomas consist of epithelioid histiocytes, Langhans giant cells and rarely foreign bodies with lymphocytes, plasma cells and caseous necrosis. The granulomatous reaction pattern is defined as a typical inflammatory pattern that is characterized by granulomas. Various etiologies can lead to granulomatous reactions. The histopathological features of cutaneous disorders with tuberculoid granuloma include cutaneous tuberculosis, tuberculids, Morbus Hansen, syphilis and rosacea. There are various clinical manifestations of tuberculoid granuloma with similar appearances which makes i

APA, Harvard, Vancouver, ISO, and other styles

33

Haering, Moritz, Christian Saleh, Phillip Jaszczuk, Markus Koehler, and Margret Hund-Georgiadis. "Intrathecal pump catheter-tip granuloma recurrence with associated myelomalacia – How safe is intrathecal analgesic infusion therapy? A case report." Surgical Neurology International 10 (April 24, 2019): 62. http://dx.doi.org/10.25259/sni-33-2019.

Full text

Abstract:

Background: A serious complication of intrathecal (IT) infusion therapy for pain management is catheter-tip-associated granuloma. Catheter-tip granulomas can lead to permanent severe neurological sequelae if not promptly detected. Case Description: We report a patient with a recurrence of a catheter-tip granuloma causing a high-grade paresis of the lower extremities and we review briefly the literature. Conclusion: Patients with IT pump therapy presenting new neurological findings need prompt imaging of the spinal axis to rule out a catheter-tip granuloma. In case of catheter-tip granuloma, ea

APA, Harvard, Vancouver, ISO, and other styles

34

Aga, Hitomi, Mitsuyoshi Hirokawa, Ayana Suzuki, et al. "Sonographic Evaluation of Nodules Newly Detected in the Neck After Thyroidectomy: Suture Granuloma Versus Recurrent Carcinoma." Ultrasound International Open 4, no. 04 (2018): E124—E130. http://dx.doi.org/10.1055/a-0749-8688.

Full text

Abstract:

AbstractThis study aimed to clarify the sonographic features of suture granuloma and recurrent carcinoma newly detected after thyroidectomy.We retrospectively analyzed ultrasound reports with images of 25 cases of suture granuloma and 18 cases of recurrent carcinoma that newly appeared in the resected area after thyroidectomy in our institution. Both suture granulomas and recurrent carcinomas more frequently exhibited multiple lesions rather than solitary lesions. Suture granulomas tended to appear in the more superficial areas than the carotid artery, while recurrent carcinomas were more comm

APA, Harvard, Vancouver, ISO, and other styles

35

Ufimtseva, Elena. "Investigation of Functional Activity of Cells in Granulomatous Inflammatory Lesions from Mice with Latent Tuberculous Infection in the NewEx VivoModel." Clinical and Developmental Immunology 2013 (2013): 1–14. http://dx.doi.org/10.1155/2013/371249.

Full text

Abstract:

The newex vivomodel system measuring functional input of individual granuloma cells to formation of granulomatous inflammatory lesions in mice with latent tuberculous infection has been developed and described in the current study. Monolayer cultures of cells that migrated from individual granulomas were established in the proposed culture settings for mouse spleen and lung granulomas induced byin vivoexposure to BCG vaccine. The cellular composition of individual granulomas was analyzed. The expression of the leukocyte surface markers such as phagocytic receptors CD11b, CD11c, CD14, and CD16/

APA, Harvard, Vancouver, ISO, and other styles

36

Rachna, Kumari, and K. Briar N. "Hospital Based Assessment of the Morphology and Etiology of Granulomatous Lesions on Histopathologically Evaluated Biopsies of the Skin and Subcutaneous Tissue." International Journal of Pharmaceutical and Clinical Research 13, no. 6 (2021): 809–12. https://doi.org/10.5281/zenodo.14228250.

Full text

Abstract:

<strong>Background</strong><strong>:</strong> Granulomatous dermatoses are common skin pathology, often need histopathological confirmation for diagnosis. Histologically six sub-types of granulomas found in granulomatous skin diseases- tuberculoid, sarcoidal, necrobiotic, suppurative, foreign body & histoid type. <strong>Objective: </strong>The aim was to study the morphology and find the etiologyof all the granulomatous lesions on histopathologically evaluated biopsies of the skin and subcutaneous tissue. <strong>Materials and methods: </strong>A prospective study

APA, Harvard, Vancouver, ISO, and other styles

37

Sincoff, Eric H., James K. Liu, Laura Matsen, et al. "A novel treatment approach to cholesterol granulomas." Journal of Neurosurgery 107, no. 2 (2007): 446–50. http://dx.doi.org/10.3171/jns-07/08/0446.

Full text

Abstract:

✓ The authors report a novel technique for the treatment of cholesterol granulomas. An extradural middle fossa approach was used to access the granuloma, with drainage through silastic tubes into the sphenoid sinus via the anteromedial triangle between V1 and V2. Cholesterol granulomas occur when the normal aeration and drainage of temporal bone air cells is occluded, resulting in vacuum formation and transudation of blood into the air cells. This process results in anaerobic breakdown of the blood with resulting cholesterol crystal formation and an inflammatory reaction. Traditional treatment

APA, Harvard, Vancouver, ISO, and other styles

38

Al-Dousary, Surayie. "Vocal Process Granuloma." Ear, Nose & Throat Journal 76, no. 6 (1997): 382–87. http://dx.doi.org/10.1177/014556139707600606.

Full text

Abstract:

Vocal process granuloma or contact ulcer is an uncommon disease in which there is chronic irritation and granulation tissue formation at the posterior third of the vocal folds. Thirteen patients (11 men and two women) with vocal process granuloma were enrolled in this study; cases of intubation granuloma were excluded. The most frequent complaints were throat irritation, frequent throat clearing and voice change. Forty-four percent of patients had a recurrence two to four months after surgery. Computed tomography (CT) of the larynx in four patients showed arytenoid sclerosis on the involved si

APA, Harvard, Vancouver, ISO, and other styles

39

Garza, Armandina, David J. Tweardy, Joel Weinstock, Balaji Viswanathan, and Prema Robinson. "Substance P Signaling Contributes to Granuloma Formation inTaenia crassicepsInfection, a Murine Model of Cysticercosis." Journal of Biomedicine and Biotechnology 2010 (2010): 1–6. http://dx.doi.org/10.1155/2010/597086.

Full text

Abstract:

Cysticercosis is an infection with larval cysts of the cestodeTaenia solium. Through pathways that are incompletely understood, dying parasites initiate a granulomatous reaction that, in the brain, causes seizures. Substance P (SP), a neuropeptide involved in pain-transmission, contributes to inflammation and previously was detected in granulomas associated with deadT. crassicepscysts. To determine if SP contributes to granuloma formation, we measured granuloma-size and levels of IL-1β, TNF-α, and IL-6 within granulomas inT. crassiceps-infected wild type (WT) mice and mice deficient in SP-prec

APA, Harvard, Vancouver, ISO, and other styles

40

Miranda, Nadia, and Katrina K. Hoyer. "Coccidioidomycosis Granulomas Informed by Other Diseases: Advancements, Gaps, and Challenges." Journal of Fungi 9, no. 6 (2023): 650. http://dx.doi.org/10.3390/jof9060650.

Full text

Abstract:

Valley fever is a respiratory disease caused by a soil fungus, Coccidioides, that is inhaled upon soil disruption. One mechanism by which the host immune system attempts to control and eliminate Coccidioides is through granuloma formation. However, very little is known about granulomas during Coccidioides infection. Granulomas were first identified in tuberculosis (TB) lungs as early as 1679, and yet many gaps in our understanding of granuloma formation, maintenance, and regulation remain. Granulomas are best defined in TB, providing clues that may be leveraged to understand Coccidioides infec

APA, Harvard, Vancouver, ISO, and other styles

41

Metwali, A., D. Elliott, A. M. Blum, J. Li, M. Sandor, and J. V. Weinstock. "T cell vasoactive intestinal peptide receptor subtype expression differs between granulomas and spleen of schistosome-infected mice." Journal of Immunology 157, no. 1 (1996): 265–70. http://dx.doi.org/10.4049/jimmunol.157.1.265.

Full text

Abstract:

Abstract Granulomas form in the liver and intestines of mice infected with the parasite Schistosoma mansoni. Vasoactive intestinal peptide (VIP) is a neurokine that can modulate aspects of the immune response by acting through receptors within the granuloma. Cloned are two novel VIP receptor (VIPR) mRNAs (VIPR1 and VIPR2) that also bind a second neurokine called pituitary adenylated cyclase-activating polypeptide (PACAP). The objective of this study was to determine if granulomas express either VIPR1 or VIPR2. Using a radioligand-binding assay, it was established that PACAP is as effective as

APA, Harvard, Vancouver, ISO, and other styles

42

Singh, Pradeep Kumar, Alekh Kumar, and Gajendra Nayak. "An unusual presentation of postauricular swelling: cholesterol granuloma." International Journal of Research in Medical Sciences 6, no. 10 (2018): 3468. http://dx.doi.org/10.18203/2320-6012.ijrms20184064.

Full text

Abstract:

Post auricular swellings are not uncommon encounterances in surgical practice. Common differential diagnosis would include dermoid and lymph nodes. Cholesterol granulomas are cystic swellings formed with a multi-nucleated giant cell reaction to red blood cells’ breakdown products, haemosiderin and cholesterol crystals. Any aerated portion of the temporal bone may develop a cholesterol granuloma; the mastoid air cells are the most common location and are the most common cystic lesion of the petrous apex. This is the first, unique and rare case of post auricular presentation of a cholesterol gra

APA, Harvard, Vancouver, ISO, and other styles

43

Lukacs, N. W., S. W. Chensue, R. M. Strieter, K. Warmington, and S. L. Kunkel. "Inflammatory granuloma formation is mediated by TNF-alpha-inducible intercellular adhesion molecule-1." Journal of Immunology 152, no. 12 (1994): 5883–89. http://dx.doi.org/10.4049/jimmunol.152.12.5883.

Full text

Abstract:

Abstract Recent studies have demonstrated a crucial role for TNF during inflammatory granuloma formation. In addition, TNF has been shown to up-regulate adhesion molecules that participate in cellular recruitment and lymphocyte activation. In the present study, we have examined the mechanism of TNF activation during Schistosoma mansoni egg granuloma formation and its relationship to the expression of ICAM-1. Our initial studies showed that high affinity human soluble TNFR coupled to the Fc portion of an Ig (sTNFR:Fc construct) could effectively diminish granuloma formation and lymphocyte activ

APA, Harvard, Vancouver, ISO, and other styles

44

Medlicott, Shaun A. C., Leslie Eidus, and Kiril Trpkov. "Isolated Pulse Granuloma in a Mesenteric Lymph Node: Unusual Nodal Manifestation Associated With Crohn Disease Complicated by Ileal Adenocarcinoma." AJSP: Reviews and Reports 23, no. 6 (2018): 271–73. http://dx.doi.org/10.1097/pcr.0000000000000273.

Full text

Abstract:

Abstract Pulse granuloma is an unusual inflammatory reaction to legumes. Pulse granulomas of the gastrointestinal tract are typically accompanied by significant mural damage due to ulceration, fistula, or perforation. We describe a solitary pulse granuloma in a mesenteric lymph node of a 74-year-old male patient with Crohn disease, who presented with an ileal adenocarcinoma, but without demonstrable fistula or perforation. To our knowledge, this is only the second reported example of Crohn disease associated with a pulse granuloma in a mesenteric node and also only the second example of a noda

APA, Harvard, Vancouver, ISO, and other styles

45

Qadir, Khurram, Ahmed Metwali, Arthur M. Blum, Jie Li, David E. Elliott та Joel V. Weinstock. "TGF-β and IL-10 regulation of IFN-γ produced in Th2-type schistosome granulomas requires IL-12". American Journal of Physiology-Gastrointestinal and Liver Physiology 281, № 4 (2001): G940—G946. http://dx.doi.org/10.1152/ajpgi.2001.281.4.g940.

Full text

Abstract:

Interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) regulate CD4+T cell interferon-γ (IFN-γ) secretion in schistosome granulomas. The role of IL-12 was determined using C57BL/6 and CBA mice. C57BL/6 IL-4 −/− granuloma cells were stimulated to produce IFN-γ when cultured with IL-10 or TGF-β neutralizing monoclonal antibody. In comparison, C57BL/6 wild-type (WT) control granuloma cells produced less IFN-γ. IL-12, IL-18, and soluble egg antigen stimulated IFN-γ release from C57BL/6 IL-4 −/− and WT mice. IFN-γ production in C57 IL-4 −/− and WT granulomas was IL-12 dependent, because IL

APA, Harvard, Vancouver, ISO, and other styles

46

Dhanasekar, G., and N. S. Jones. "Endoscopic trans-sphenoidal removal of cholesterol granuloma of the petrous apex: case report and literature review." Journal of Laryngology & Otology 125, no. 2 (2010): 169–72. http://dx.doi.org/10.1017/s0022215110002227.

Full text

Abstract:

AbstractObjective:We report a case of cholesterol granuloma of the petrous apex which was surgically treated via an endoscopic trans-sphenoidal approach.Methods:Case report and review of the literature concerning cholesterol granulomas of the petrous apex and their management.Results:The lesion was approached endoscopically via a bilateral sphenoidotomy with removal of the vomer. A large cholesterol granuloma was evacuated and marsupialised. The patient made an uneventful recovery.Conclusion:Trans-sphenoidal access to the petrous apex represents an alternative route for the drainage and ventil

APA, Harvard, Vancouver, ISO, and other styles

47

Mendonça, Rodrigo, Cleiton Schweitzer Peron, Marco Antônio Stefani, and Pasquale Gallo. "Cerebral cholesterol granuloma: case report." Arquivos de Neuro-Psiquiatria 65, no. 2b (2007): 540–41. http://dx.doi.org/10.1590/s0004-282x2007000300036.

Full text

Abstract:

Intracranial cholesterol granulomas are rare lesions, and have been registered in petrous apex region. The presence of an intracerebral cholesterol granuloma is an uncommun event. We report the case of a 20-years-old woman who undergone craniotomy for resection of a temporal mass. Pathologic examination show a cholesterol granuloma.

APA, Harvard, Vancouver, ISO, and other styles

48

Srinivas, Teerthanath, and Hariprasad S. "Granulomatous dermatosis: histopathological study in a tertiary care hospital." International Journal of Research in Medical Sciences 5, no. 9 (2017): 3869. http://dx.doi.org/10.18203/2320-6012.ijrms20173659.

Full text

Abstract:

Background: Granulomatous dermatosis shares the histological finding of granuloma formation; it is usually formed because of the persistence of a non-degradable product of active hypersensitivity. The identical histological picture may be produced by several causes, which pose a diagnostic challenge to dermatopathologist, Present study aims at classifying cutaneous granulomatous dermatosis based on the morphology and aetiology of granulomas, and to highlight its significance for specific clinical diagnosis.Methods: A retrospective analysis of skin biopsy was done and cases of cutaneous granulo

APA, Harvard, Vancouver, ISO, and other styles

49

Marcus, Sarah Ann, Melinda Herbath, Zsuzsanna Fabry, and Matyas Sandor. "Dynamic changes in Mycobacterium tuberculosis-induced granulomas: developing new tools." Journal of Immunology 200, no. 1_Supplement (2018): 117.19. http://dx.doi.org/10.4049/jimmunol.200.supp.117.19.

Full text

Abstract:

Abstract Continuous cell replacement has been demonstrated in a transplantation model of BCG infected liver, however, the Mtb lung granuloma has yet to be studied as lung tissue is not amenable to granuloma transplantation. To demonstrate the plasticity of Mtb lung granulomas, we treated mice 6 weeks post infection with chemokine inhibitors for 7 days. Treated lungs showed a strong, significant reduction in granuloma size, which suggests continuous cell replacement and indicates that Mtb granulomas are actively maintained during infection. To examine cell fate in more detail, we utilized STOCK

APA, Harvard, Vancouver, ISO, and other styles

50

Nugroho, Y. Slamet, Reviono Reviono, Suradi Suradi та Diding Heri Prasetyo. "Effect of Andrographolide on The Expression of TNF-α and Pulmonary Tuberculosis in Rats Granulomas are Infected With Mycobacterium tuberculosis". Jurnal Respirologi Indonesia 38, № 2 (2018): 75–82. http://dx.doi.org/10.36497/jri.v38i2.161.

Full text

Abstract:

Background. Andrographolide as an anti-inflammatory inhibit activation of NF-κβ, the production of TNF-α, IL-12, pressing the release inducibele nitic oxide synthase (iNOS), inhibiting the release of COX-2 in human fibroblast cells and also prevents the production of oxygen radicals. TNF- α stimulates the migration of immune cells to get to the site of infection, contribute to the formation of granulomas, and can control the disease progresificity. Methods. The study aims to analyze the effect of andrographolide on the expression of TNF-α and tuberculosis granuloma in mice infected with

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!