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Journal articles on the topic 'Granulomatous cheilitis of Miescher'

Author: Grafiati

Published: 28 May 2022

Last updated: 29 May 2022

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1

Adhikari, Ram Chandra, and Mahesh Shah. "Miescher’s cheilitis: A case report with literature review." Journal of Pathology of Nepal 8, no. 1 (April 3, 2018): 1313–16. http://dx.doi.org/10.3126/jpn.v8i1.19465.

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Miescher’s cheilitis is an inflammatory disorder characterized by chronic lip swelling due to granulomatous inflammation. It is rare disorder first described by Miescher in 1945. It is monosymptomatic form of Melkersson-Rosenthal syndrome. We report a case of Miescher’s cheilitis in a 59-year old lady presented with recurrent swelling and erythema of upper lip and submental area with no features of facial palsy and fissuring of tongue. Laboratory tests including serum complement C3, C4 and C1 esterase inhibitor functional were within normal limits. The biopsy from the upper lip revealed dermal edema, dilated lymphatic channels and multiple granulomas. After exclusion of other causes of orofacial granulomatosis, the diagnosis of Miescher’s cheilitis was made. Patient was treated with oral hydroxychloroquine and topical tacrolimus and mometasone cream with gradual improvement.

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2

Friedrich, W., and J. Timmermann. "Die Cheilitis granulomatosa Miescher." Laryngo-Rhino-Otologie 69, no. 11 (November 1990): 564–68. http://dx.doi.org/10.1055/s-2007-998254.

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3

Kamra, Nidhi, BalwinderKaur Brar, and BB Mahajan. "Cheilitis granulomatosa (Miescher granulomatous macrocheilitis) with Down syndrome: A rare alliance." Indian Journal of Paediatric Dermatology 17, no. 1 (2016): 50. http://dx.doi.org/10.4103/2319-7250.172458.

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4

Ridder, Gerd Jürgen, Milo Fradis, and Erwin Löhle. "Cheilitis Granulomatosa Miescher: Treatment with Clofazimine and Review of the Literature." Annals of Otology, Rhinology & Laryngology 110, no. 10 (October 2001): 964–67. http://dx.doi.org/10.1177/000348940111001013.

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Cheilitis granulomatosa Miescher is a rare condition of unknown cause characterized by intermittent lip swelling that gradually persists and causes cosmetic deformity. We report the case of a young woman with cheilitis granulomatosa as a monosymptomatic manifestation of Melkersson-Rosenthal syndrome successfully treated by the antileprosy agent clofazimine, and propose clofazimine as an alternative treatment in cases refractory to corticosteroids. The differential diagnosis and current methods of treatment are summarized, and the literature is reviewed and discussed.

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5

Oliver, D. W., and M. J. L. Scott. "Lip reduction cheiloplasty for Miescher's granulomatous macrocheilitis (Cheilitis granulomatosa) in childhood." Clinical and Experimental Dermatology 27, no. 2 (March 2002): 129–31. http://dx.doi.org/10.1046/j.1365-2230.2002.00974.x.

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6

Shivaram, Bhumika, AshaGowrappala Shanmukhappa, Leelavathy Budamakuntala, and Archana Samynathan. "Idiopathic granulomatous cheilitis of Miescher in a young patient: A rare entity and its successful treatment." Indian Journal of Paediatric Dermatology 18, no. 3 (2017): 217. http://dx.doi.org/10.4103/2319-7250.188453.

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7

Hernandez, Gonzalo, Francisco Hernandez, and Miguel Lucas. "Miescher's granulomatous cheilitis: Literature review and report of a case." Journal of Oral and Maxillofacial Surgery 44, no. 6 (June 1986): 474–78. http://dx.doi.org/10.1016/s0278-2391(86)80015-5.

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8

Ikonnikova, E. V. Ikonnikova, L. S. Kruglova Kruglova, N. E. Manturova Manturova, and V. A. Shchekochikhin Shchekochikhin. "Miescher’s granulomatous cheilitis or delayed inflammatory edema of the upper lip after filler injection: difficulties in differential diagnosis." Pharmateca 14_2021 (December 24, 2021): 120–23. http://dx.doi.org/10.18565/pharmateca.2021.14.120-123.

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9

Camacho, F., B. Garcia-Bravo, and A. Carrizosa. "Treatment of Miescher's cheilitis granulomatosa in Melkersson-Rosenthal syndrome." Journal of the European Academy of Dermatology and Venereology 15, no. 6 (November 2001): 546–49. http://dx.doi.org/10.1046/j.1468-3083.2001.00270.x.

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10

Baqai, MF, MT Baqai, and T. Kashif. "Granulomatous cheilitis." Journal of the Royal College of Physicians of Edinburgh 43, no. 4 (2013): 312–14. http://dx.doi.org/10.4997/jrcpe.2013.408.

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11

Shaikh, A. B., T. M. Arendorf, M. R. Darling, and V. M. Phillips. "Granulomatous cheilitis." Oral Surgery, Oral Medicine, Oral Pathology 67, no. 5 (May 1989): 527–30. http://dx.doi.org/10.1016/0030-4220(89)90267-3.

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12

Thomas, S. E., and S. S. Bleehen. "(31) Granulomatous cheilitis." British Journal of Dermatology 115, s30 (July 1986): 78–79. http://dx.doi.org/10.1111/j.1365-2133.1986.tb07726.x.

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13

Ahmad, Ishfaq, and David Owens. "Granulomatous Cheilitis and Crohn's Disease." Canadian Journal of Gastroenterology 15, no. 4 (2001): 273–75. http://dx.doi.org/10.1155/2001/602183.

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Granulomatous cheilitis is characterized by recurrent swelling of the labial tissues and granulomatous histology. Granulomatous cheilitis has been recognized as an early manifestation of Crohn's disease. It may follow, coincide with or precede the onset of Crohn's disease. The first case presented involved an extraintestinal manifestation of Crohn's disease, and the second case presented is of development of granulomatous cheilitis a year before the onset of symptomatic Crohn's disease. Although chronic granulomatous cheilitis is a very rare disorder, once it is diagnosed, the patient should be followed up carefully. These patients should be investigated for asymptomatic Crohn's disease either when the diagnosis of granulomatous cheilitis is confirmed or when gastrointestinal symptoms develop.

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14

Charpentier, Chloé, Diane Kottler, Charlotte Fite, Anne-Laure Pelletier, Lydia Deschamps, and Vincent Descamps. "A Surprising Granulomatous Cheilitis." Gastroenterology 154, no. 5 (April 2018): 1239–40. http://dx.doi.org/10.1053/j.gastro.2017.07.005.

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15

Tomov, Georgi, Parvan Voynov, and Svitlana Bachurska. "Granulomatous Cheilitis or Tuberculid?" Antibiotics 11, no. 4 (April 14, 2022): 522. http://dx.doi.org/10.3390/antibiotics11040522.

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The granulomatous cheilitis (GC) presents a heterogeneous group of disorders characterised by a granulomatous inflammation/reaction of the lips to various stimuli. Numerous etiologies have been proposed, including genetic, immunologic, allergic and infectious. Among the secondary causes of GC, an infection by Mycobacterium tuberculosis (MBT) should be considered. In such cases, the GC could be the clinical presentation of a tuberculid resulting from a hypersensitivity reaction to an underlying focus of active (ATBI) or latent tuberculosis infection (LTBI). This communication describes an immunocompetent patient diagnosed with GC resulting from tuberculid, who responded well to Isoniazid monotherapy.

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16

Thiriar, S., E. Deroux, N. Dourov, L. Evrard, M. O. Peny, P. Simon, and D. Parent. "Granulomatous Vulvitis, Granulomatous Cheilitis: A Single Diagnosis?" Dermatology 196, no. 4 (1998): 455–58. http://dx.doi.org/10.1159/000017948.

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17

Bhat, RameshM, Sukumar Dandakeri, Nelee Bisen, and SrinathM Kambil. "Granulomatous cheilitis with granulomatous vulvitis: A rare association." Indian Journal of Dermatology, Venereology, and Leprology 79, no. 6 (2013): 799. http://dx.doi.org/10.4103/0378-6323.120733.

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18

Arora, Pooja, and Arvind Ahuja. "Granulomatous cheilitis with gingival enlargement." Indian Journal of Medical Research 144, no. 6 (2016): 946. http://dx.doi.org/10.4103/ijmr.ijmr_1950_15.

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19

Genece, Jordan, Justin Chu, Stephanie Liu, Nahla Shihab, and Jonathan Ungar. "Granulomatous Cheilitis: A Case Report." SKIN The Journal of Cutaneous Medicine 4, no. 2 (March 8, 2020): 161. http://dx.doi.org/10.25251/skin.4.2.13.

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Introduction: Granulomatous cheilitis is a rare condition, with an unknown etiological pathway, resulting in inflammation of the lips. This case report demonstrates the efficacy of intralesional triamcinolone with this persistent disorder.Case report: A 19-year old man presented with orofacial swelling on the right side for approximately 18 months. Previous treatments of minocycline and metronidazole were unsuccessful. The patient has no other symptoms and an unremarkable family history. A regiment of topical anesthetic and intralesional triamcinolone showed significant improvement.Discussion: This rare condition has many possible contributory factors with very few established treatments. Our patient appeared to present either granulomatous cheilitis or monosymptomatic Melkersson-Rosenthal syndrome. Our primary goal was to abate the patient’s symptoms for their comfort, hence the implication of the benzocaine gel.Conclusion: There are various therapeutic methods described, however, we believe intralesional triamcinolone injections with prior application of topical anesthetic to ease discomfort, could be an alternative treatment.

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20

KANO, Y., T. SHIOHARA, A. YAGITA, and M. NAGASHIMA. "Granulomatous cheilitis and Crohn's disease." British Journal of Dermatology 123, no. 3 (September 1990): 409–12. http://dx.doi.org/10.1111/j.1365-2133.1990.tb06303.x.

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21

Harms, M., I. Masouyé, and J. H. Saurat. "Silica Granuloma Mimicking Granulomatous Cheilitis." Dermatology 181, no. 3 (1990): 246–47. http://dx.doi.org/10.1159/000247945.

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22

Bandla, Pujitha, Bhakti Sarangi, Guruprasad H. Shankar, and Varsha Sharma. "Granulomatous vulvitis and Gullain-Barre syndrome in pediatric Crohn’s disease: a case report." International Journal of Contemporary Pediatrics 8, no. 6 (May 25, 2021): 1121. http://dx.doi.org/10.18203/2349-3291.ijcp20212061.

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Granulomatous vulvitis/cheilitis may occur rarely as an extraintestinal manifestation of Crohn’s disease (CD) and may precede the development of gastrointestinal symptoms. Guillain-Barre syndrome (GBS) is associated with a wide variety of illnesses including inflammatory bowel disease. Though the immunologic abnormalities in inflammatory bowel disease may encompass both granulomatous inflammation as well as autoimmune components, the combination of CD, GBS and granulomatous vulvitis/cheilitis in the same patient has not been described in literature. We hereby reported a 14 year old girl with granulomatous vulvitis/cheilitis for 4 years preceding the development of gastrointestinal manifestations of CD, who also had GBS during the course of hospitalization.

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23

Ghosh, Sarmistha, Somenath Sarkar, and Dipayan Sengupta. "Clinically granulomatous cheilitis with plasma cells." Indian Dermatology Online Journal 7, no. 2 (2016): 96. http://dx.doi.org/10.4103/2229-5178.178094.

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24

Nair, PragyaA, and TrushaM Patel. "Granulomatous cheilitis involving the lower lip." Egyptian Journal of Dermatology and Venerology 37, no. 2 (2017): 85. http://dx.doi.org/10.4103/ejdv.ejdv_8_17.

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25

INUI, Shigeki, Satoshi ITAMI, and Ichiro KATAYAMA. "Granulomatous cheilitis successfully treated with roxithromycin." Journal of Dermatology 35, no. 4 (April 2008): 244–45. http://dx.doi.org/10.1111/j.1346-8138.2008.00455.x.

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26

BUNKER, C. B., and J. J. H. GILKES. "(52) Granulomatous cheilitis and Crohn's disease." British Journal of Dermatology 125, s38 (July 1991): 75a—76. http://dx.doi.org/10.1111/j.1365-2133.1991.tb05521.x.

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27

Oliveira, Ana Maria, Manuela Martins, Alexandra Martins, and João Ramos de Deus. "Granulomatous Cheilitis Associated With Crohnʼs Disease." American Journal of Gastroenterology 111, no. 4 (April 2016): 456. http://dx.doi.org/10.1038/ajg.2015.378.

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28

Kavala, Mukaddes, Sibel Sudogan, Burce Can, and Sukran Sarigul. "Granulomatous cheilitis resulting from a tuberculide." International Journal of Dermatology 43, no. 7 (July 2004): 524–27. http://dx.doi.org/10.1111/j.1365-4632.2004.02211.x.

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29

Barry, Olivia. "Treatment of Granulomatous Cheilitis With Infliximab." Archives of Dermatology 141, no. 9 (September 1, 2005): 1080. http://dx.doi.org/10.1001/archderm.141.9.1080.

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30

Taxonera, Carlos, Cristina Alba, Michel Colmenares, David Olivares, and Enrique Rey. "Recurrent granulomatous cheilitis associated with Crohn’s disease successfully treated with ustekinumab: case report and literature review." Therapeutic Advances in Gastroenterology 13 (January 2020): 175628482093432. http://dx.doi.org/10.1177/1756284820934327.

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Granulomatous cheilitis, characterized by persistent inflammation of the lips and a granulomatous histology, is sometimes associated with Crohn’s disease and is a therapeutic challenge. Reported evidence indicates treatment with an anti-TNF agent (mainly infliximab) is the most recommended therapeutic option after failure of conventional treatments. The clinical case reported the effectiveness of ustekinumab, a monoclonal antibody against interleukins 12/23, to induce the remission of severe and recurrent granulomatous cheilitis in a patient with Crohn’s disease.

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31

Paravina, Mirjana. "Cheilitis Glandularis Apostematosa in a Female Patient – a Case Report." Serbian Journal of Dermatology and Venerology 5, no. 4 (December 1, 2013): 177–82. http://dx.doi.org/10.2478/sjdv-2013-0015.

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Abstract Cheilitis is an inflammatory condition of the vermilion border of the lips, which is the junction between the skin and the mucosa. Cheilitis may arise as a primary disorder of the vermilion zone; the inflammation may extend from the nearby skin, or less often from the oral mucosa. Primary cheilitis lesions are either superficial or deep. Deep types include cheilitis glandularis (inflammatory changes and lip gland swelling), and granulomatous cheilitis (chronic swelling of the lip due to granulomatous inflammation mostly of unknown origin). Cheilitis glandularis is a rare condition that mostly affects the lower lip and it is characterized by nodular enlargement, reduced mobility and lip erosion. Based on clinical presentation, cheilitis glandularis may be classified into three subtypes: simplex (described as Puente and Acevedo), superficial suppurative (described by Baelz-Unna), and the most severe type - deep suppurative, also known as cheilitis glandularis apostematosa (Volkmann’s cheilitis) characterized by deep-seated inflammation forming abscesses and fistulous tracts. This is a case report of a female patient with a deep suppurative type of cheilitis affecting both lips. Treatment with systemic antibiotics (using antibiogram tests), corticosteroids and topical therapy resulted in significant improvement.

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32

THIRIAR, S. "Granulomatous vulvitis, granulomatous cheilitis: Two aspects of the same disease." Journal of the European Academy of Dermatology and Venereology 11 (September 1998): S145. http://dx.doi.org/10.1016/s0926-9959(98)95086-3.

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33

Dusi, Stefano, Giovanni Poli, Giorgio Berton, Paola Catalano, Cleto Veller Fornas, and Andrea Peserico. "Chronic Granulomatous Disease in an Adult Female with Granulomatous Cheilitis." Acta Haematologica 84, no. 1 (1990): 49–56. http://dx.doi.org/10.1159/000205028.

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34

Bouguezzi, Adel, Omar Neji, Chokri Abdellatif, Sameh Sioud, Hajer Hentati, and Jemil Selmi. "Miescher Granulomatous Macrocheilitis and Management with Triamcinolone Acetonide." International Journal of Research Studies in Medical and Health Sciences 5, no. 6 (2020): 12–15. http://dx.doi.org/10.22259/ijrsmhs.0506003.

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35

Gupta, Ambika, and Harneet Singh. "Granulomatous Cheilitis: Successful Treatment of Two Recalcitrant Cases with Combination Drug Therapy." Case Reports in Dermatological Medicine 2014 (2014): 1–4. http://dx.doi.org/10.1155/2014/509262.

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Granulomatous cheilitis is a rare, idiopathic, inflammatory disorder which usually affects young adults. It is characterized by persistent, diffuse, nontender, soft-to-firm swelling of one or both lips. Various treatment modalities have been suggested. In spite of the best treatment, recurrence of the disease is very common. We report two cases of granulomatous cheilitis treated with a combination of steroids, metronidazole, and minocycline with no signs of relapse at one-year follow-up.

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36

ISHIGURO, Emiko, Atsushi HATAMOCHI, Yoichiro HAMASAKI, Satoko ISHIKAWA, and Soji YAMAZAKI. "Successful treatment of granulomatous cheilitis with roxithromycin." Journal of Dermatology 35, no. 9 (September 2008): 598–600. http://dx.doi.org/10.1111/j.1346-8138.2008.00530.x.

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37

Kolokotronis, A., D. Antoniades, G. Trigonidis, and P. Papanagiotou. "Granulomatous cheilitis: a study of six cases." Oral Diseases 3, no. 3 (June 28, 2008): 188–92. http://dx.doi.org/10.1111/j.1601-0825.1997.tb00034.x.

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38

Thomas, Peter. "Successful Treatment of Granulomatous Cheilitis With Thalidomide." Archives of Dermatology 139, no. 2 (February 1, 2003): 136. http://dx.doi.org/10.1001/archderm.139.2.136.

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39

Ruiz Villaverde, Ricardo, and Daniel Sánchez Cano. "Successful treatment of granulomatous cheilitis with adalimumab." International Journal of Dermatology 51, no. 1 (December 20, 2011): 118–20. http://dx.doi.org/10.1111/j.1365-4632.2010.04507.x.

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40

SHEHADE, S. A., and I. S. FOULDS. "Granulomatous cheilitis and a positive Kveim test." British Journal of Dermatology 115, no. 5 (November 1986): 619–22. http://dx.doi.org/10.1111/j.1365-2133.1986.tb05774.x.

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41

Bourgeois-Droin, Chantal, Stephane Havard, Françoise Granier, Marc Vesse, Jean-Louis Salomon, Jean Furioli, and Maggy Grossin. "Granulomatous cheilitis in two children with sarcoidosis." Journal of the American Academy of Dermatology 29, no. 5 (November 1993): 822–24. http://dx.doi.org/10.1016/0190-9622(93)70246-p.

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42

Bhattacharya, M., K. Rajeshwari, K. Sardana, and P. Gupta. "Granulomatous cheilitis secondary to tuberculosis in a child." Journal of Postgraduate Medicine 55, no. 3 (2009): 190. http://dx.doi.org/10.4103/0022-3859.57400.

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43

Sbano, Paolo, Pietro Rubegni, Massimiliano Risulo, Maria Caterina De Nisi, and Michele Fimiani. "A case of idiopathic granulomatous cheilitis and vulvitis." International Journal of Dermatology 46, no. 7 (July 2007): 720–21. http://dx.doi.org/10.1111/j.1365-4632.2007.03173.x.

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44

Veller Fornasa, C., P. Catalano, and A. Peserico. "Minocycline in Granulomatous Cheilitis: Experience with 6 Cases." Dermatology 185, no. 3 (1992): 220. http://dx.doi.org/10.1159/000247454.

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45

Lemasle, Emilie, Fabrice Jardin, Anne Benedicte Duval, Philippe Courville, Gérard Buchonnet, Marie Paule Callat, Aspasia Stamatoullas, and Herve Tilly. "Miescher cheilitis and myelomonocytic leukemia: a fortuitous association or a rare paraneoplastic syndrome?" Leukemia & Lymphoma 51, no. 4 (April 2010): 730–32. http://dx.doi.org/10.3109/10428191003611410.

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46

Tatnall, F. M., H. J. Dodd, and I. Sarkany. "Crohn's disease with metastatic cutaneous involvement and granulomatous cheilitis." Journal of the Royal Society of Medicine 80, no. 1 (January 1987): 49–51. http://dx.doi.org/10.1177/014107688708000119.

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47

Banks, T., and S. Gada. "A comprehensive review of current treatments for granulomatous cheilitis." British Journal of Dermatology 166, no. 5 (April 23, 2012): 934–37. http://dx.doi.org/10.1111/j.1365-2133.2011.10794.x.

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48

Gavioli, Camila FB, Giovanna P. Florezi, Silvia V. Lourenço, and Marcello MS Nico. "Clinical Profile of Melkersson-Rosenthal Syndrome/Orofacial Granulomatosis: A Review of 51 Patients." Journal of Cutaneous Medicine and Surgery 25, no. 4 (February 11, 2021): 390–96. http://dx.doi.org/10.1177/1203475421995132.

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Background Melkersson–Rosenthal syndrome (MRS) is a rare disease characterized by the triad of granulomatous cheilitis, fissured tongue, and facial paralysis. Publications concerning large series are rare in the literature. Objectives To describe the clinical and histopathological characteristics of patients with complete and oligosymptomatic forms of MRS. Methods A retrospective records review was performed for the diagnoses of Melkersson-Rosenthal syndrome, granulomatous cheilitis, and orofacial granulomatosis at oral Diseases Clinic of the Department of Dermatology, University of São Paulo, Brazil (2003, 2017). Results A total of 51 patients were included, mean age at presentation 35.69 years. Four patients were younger than 18 years. The complete triad of was observed in 10 patients. The rare findings of granulomatous blepharitis, gingivitis and palatitis are presented. Comorbidities included Crohn’s disease (5 patients), migraine headaches (1 patient) and convulsions (2 patients). Granulomatous inflammatory infiltrate was detected in 31 biopsies. Medical therapies included included oral and intralesional steroids, thalidomide, dapsone, azathioprine, tetracycline, methotrexate, and surgery, with variable responses. Conclusions Our report meant to draw attention to the clinical spectrum of this rare disorder, mainly to oligosymptomatic forms and rarer presentations.

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49

Nabatian, Adam S., Kara N. Shah, Elizaveta Iofel, Stephen Rosenberg, Parisa Javidian, Amy Pappert, and Sandy S. Milgraum. "Asymptomatic Granulomatous Vulvitis and Granulomatous Cheilitis in Childhood: The Need for Crohn Disease Workup." Journal of Pediatric Gastroenterology and Nutrition 53, no. 1 (July 2011): 100–101. http://dx.doi.org/10.1097/mpg.0b013e31820bcff9.

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50

Nozicka, Z. "Endovasal granulomatous lymphangiitis as a pathogenetic factor in cheilitis granulomatosa." Journal of Oral Pathology and Medicine 14, no. 5 (May 1985): 363–65. http://dx.doi.org/10.1111/j.1600-0714.1985.tb00506.x.

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