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Journal articles on the topic 'Gravid mice'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Maki, Jun, and Toshio Yanagisawa. "Infectivity of Hymenolepis nana eggs from faecal pellets in the rectum of mice." Journal of Helminthology 61, no. 4 (1987): 341–45. http://dx.doi.org/10.1017/s0022149x00010270.

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ABSTRACTThe infectivity of Hymenolepis nana eggs from faecal pellets in the rectum of mice was compared with that of the eggs in gravid proglottids of adult H. nana and with that of the eggs in excreted faecal pellets to find out a simple method for collecting H. nana eggs of high infectivity to mice. Eggs from faecal pellets in the rectum showed higher infectivity than those from gravid proglottids and as high infectivity as those from gravid proglottids selected by a watch-glass rotation technique. Eggs in faecal pellets in the rectum did not lose infectivity until 4 h after they were excret

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2

Dettman, C. D., and S. B. Higgins-Opitz. "The infection characteristics of the antelope schistosomes, Schistosoma margrebowiei and S. leiperi, in inbred BALB/c mice and in Mastomys coucha." Journal of Helminthology 68, no. 1 (1994): 19–33. http://dx.doi.org/10.1017/s0022149x00013420.

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AbstractDetailed studies were carried out to assess the infection characteristics of the antelope schistosomes in BALB/c mice and Mastomys coucha. Both schistosome species reached sexual maturity in these hosts. However, they differed markedly in terms of egg production rates and preferred sites of tissue egg deposition. Tissue egg deposition commenced between 4 and 5 weeks in the case of Schistosoma margrebowiei and between 6 and 7 weeks in the case of S. leiperi. Tissue egg accumulation rates of S. leiperi were calculated to be 334 and 311 eggs/gravid worm pair/day in mice and M. coucha, res

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3

Ratajczak, Christine K., Erik D. Herzog, and Louis J. Muglia. "Clock gene expression in gravid uterus and extra-embryonic tissues during late gestation in the mouse." Reproduction, Fertility and Development 22, no. 5 (2010): 743. http://dx.doi.org/10.1071/rd09243.

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Evidence in humans and rodents suggests the importance of circadian rhythmicity in parturition. A molecular clock underlies the generation of circadian rhythmicity. While this molecular clock has been identified in numerous tissues, the expression and regulation of clock genes in tissues relevant to parturition is largely undefined. Here, the expression and regulation of the clock genes Bmal1, Clock, cryptochrome (Cry1/2) and period (Per1/2) was examined in the murine gravid uterus, placenta and fetal membranes during late gestation. All clock genes examined were expressed in the tissues of in

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Al-Olayan, Ebtsam, Maha Elamin, Eman Alshehri, et al. "Morphological, Molecular, and Pathological Appraisal of Hymenolepis nana (Hymenolepididae) Infecting Laboratory Mice (Mus musculus)." Microscopy and Microanalysis 26, no. 2 (2020): 348–62. http://dx.doi.org/10.1017/s1431927620000161.

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AbstractHymenolepis nana, typically a parasite found in conventionally established mouse colonies, has zoonotic potential characterized by autoinfection and direct life cycle. The objective of this study was to determine the rate of parasite infection in laboratory mice. The hymenolepidide cestode infected 40% of the 50 mice sampled. The rate of infection in males (52%) was higher than in females (28%). Morphological studies on the cestode parasite showed that worms had a globular scolex with four suckers, a retractable rostellum with 20–30 hooks, and a short unsegmented neck. In addition, the

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Hamrick, Terri S., John R. Horton, Patricia A. Spears, Edward A. Havell, Ida W. Smoak, and Paul E. Orndorff. "Influence of Pregnancy on the Pathogenesis of Listeriosis in Mice Inoculated Intragastrically." Infection and Immunity 71, no. 9 (2003): 5202–9. http://dx.doi.org/10.1128/iai.71.9.5202-5209.2003.

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ABSTRACT Pregnancy increases the risk of listeriosis, a systemic disease caused by Listeria monocytogenes. However, there is incomplete agreement on the reasons for this increased risk. We examined two features of listeriosis in gravid and nongravid female mice following intragastric (gavage) inoculation, namely, (i) disease severity (measured by lethality) and (ii) listerial infectivity (measured by liver and spleen colonization levels up to 120 h postinoculation). Two listerial strains of differing serotype (1/2a and 4nonb) were initially employed. Neither strain produced a lethal infection

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Sato, Hiroshi, and Masao Kamiya. "Establishment, development and fecundity of Taenia crassiceps in the intestine of prednisolone-treated Mongolian gerbils and inbred mice." Journal of Helminthology 64, no. 3 (1990): 217–22. http://dx.doi.org/10.1017/s0022149x00012190.

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ABSTRACTWorm establishment, development and fecundity of Taenia crassiceps in the intestine of prednisolone (PTBA)-treated, 15- and 4-week-old Mongolian gerbils and 9-week-old inbred mice of 4 strains (AKR/J, BALB/cAn, B10D2/oSn and C57BL/KsJ) were investigated following oral administration of metacestodes. Gerbils were divided into 5 groups of 4 animals each according to the host age and commencement day of PTBA-treatment (day −13, −7 or 0 relative to infection). Worm recovery from the intestine on day 35 postinfection was not affected by host age, but fewer worms were recovered the earlier t

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Ostlind, D. A., M. A. Nartowicz, and W. G. Mickle. "Efficacy of ivermectin against Syphacia obvelata (Nematoda) in mice." Journal of Helminthology 59, no. 3 (1985): 257–61. http://dx.doi.org/10.1017/s0022149x00008051.

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ABSTRACTIvermectin was evaluated against natural and artificial pinworm (Syphacia) infections in mice. Ivermectin given in the diet for 6 days at 0·0005% was 99% effective against both immature and adult worms. A diet level of 0·0004% reduced immature and mature pinworm by 99 and 75%, respectively but 0·0001% was inactive. One oral dose of 2·0mg/kg was 100 and 97% effective against gravid females and immature worms, respectively. A dose of 1·0 mg/kg was 96 and 66% effective against the same parasitic stages. A similar effect was observed against adult male worms where 94 and 86% were removed b

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8

Hemmeryckx, Bianca, Rita van Bree, Berthe Van Hoef, Lisbeth Vercruysse, H. Roger Lijnen, and Johan Verhaeghe. "Adverse Adipose Phenotype and Hyperinsulinemia in Gravid Mice Deficient in Placental Growth Factor." Endocrinology 149, no. 5 (2008): 2176–83. http://dx.doi.org/10.1210/en.2007-1272.

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Pregnancy-induced metabolic changes are regulated by signals from an expanded adipose organ. Placental growth factor (PlGF), acting through vascular endothelial growth factor receptor-1, may be among those signals. There is a steep rise in circulating PlGF during normal pregnancy, which is repressed in gravidas who develop preeclampsia. PlGF-deficiency in mice impairs adipose vascularization and development. Here we studied young-adult PlGF-deficient (PlGF−/−) and wild-type mice on a high-fat diet in the nongravid state and at embryonic day (E) 13.5 or E18.5 of gestation. Litter size and weigh

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Marston, Lindsay A., Gerad A. Fox, Kim Y. Hung, Shannon J. Delo, and William K. Hayes. "A Sting Operation: Risk Assessment and Venom Expenditure by Arizona Bark Scorpions (Centruroides sculpturatus) in a Defensive Context." Toxins 17, no. 4 (2025): 198. https://doi.org/10.3390/toxins17040198.

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Scorpion antipredator behavior incorporates risk assessment that informs decision-making and venom usage. We quantified antipredator behaviors of the clinically significant Arizona bark scorpion (Centruroides sculpturatus) in their natural environment using exposure to two stimuli: a freshly thawed laboratory mouse (Mus musculus) and a membrane-covered glass beaker. We videotaped and compared envenomation behaviors between sexes (females, gravid females, and males), across sizes, and between animal orientations (on vertical or horizontal substrates). Results failed to show consistent support f

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10

Achmad, Agung Budianto, Sri Pantja Madyawati, and Widjiati Widjiati. "STEM CELL THERAPY ON ANIMAL MODEL (Rattus norvegicus) END GESTATIONAL TIME EXPOSED TO CARBON BLACK AS OBSERVED FROM CASPASE-3 EXPRESSION." Journal Of Vocational Health Studies 1, no. 3 (2018): 102. http://dx.doi.org/10.20473/jvhs.v1.i3.2018.102-106.

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Background: Air pollution in the form of Diesel Exhaust Particles emerging from motor vehicles are harmful to health that have adverse reproductive health impacts, especially during pregnancy. The use of stem cells in treating white mice (Rattus norvegicus) exposed to carbon black can reveal the potential for treatment of placental impairment during pregnancy. Purpose: to demonstrate the effectivity of Rat Bone Marrow Mesenchymal Stem Cell therapy on rats (Rattus norvegicus) exposed to carbon black as observed from caspase-3 expression. Methods: This research uses a completely randomized desig

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Wabai, Yvonne W., Charles G. Githinji, Joseph N. Ngeranwa, and John K. Mwonjoria. "Teratogenic Effects of Carissa spinarum and Azadirachta indica Aqueous Extracts in Mice." Journal of Phytopharmacology 12, no. 1 (2023): 20–26. http://dx.doi.org/10.31254/phyto.2023.12103.

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Carissa spinarum (mũkawa in Kikuyu, lamuriak in Maasai) and Azadirachta indica (neem, mwarubaini in Kiswahili) are widely used in African communities. C. spinarum is used as food and as treatment for gonorrhoea, cancer, and abnormal pain in pregnancy. A. indica is used as a mosquito-repellent and as treatment for malaria and dental carries. Both plants have broad biological activities including anticancer, hypoglycaemic, antinociceptive, and anti-inflammatory activity. However, data on their safety for use during pregnancy is scarce. This study aimed to determine the teratogenic effects of C.

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Davis, N. E. "Endemic echinostome infections of candidate hosts." Journal of Helminthology 79, no. 2 (2005): 127–32. http://dx.doi.org/10.1079/joh2005284.

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AbstractWild Lymnaea tomentosa snails, recovered from Lake Wanaka, New Zealand, were established in the laboratory. Wild snails, naturally infected with echinostomes, provided metacercariae for infection of laboratory maintained snails. Metacercarial cysts from wild and laboratory snails were then used to attempt infection of definitive host candidates. Laboratory snails provided convenient packaging of known numbers of cysts. Metacercariae excysted in the small intestines of ducklings to mature in 6 days. Worms were expelled as they became gravid. Attempts to establish infections in experimen

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13

Niedermeyer, J., M. Kriz, F. Hilberg, et al. "Targeted Disruption of Mouse Fibroblast Activation Protein." Molecular and Cellular Biology 20, no. 3 (2000): 1089–94. http://dx.doi.org/10.1128/mcb.20.3.1089-1094.2000.

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ABSTRACT Human fibroblast activation protein (FAP), a member of the serine prolyl oligopeptidase family, is a type II cell surface glycoprotein selectively expressed by fibroblastic cells in areas of active tissue remodeling, such as the embryonic mesenchyme, areas of wound healing, the gravid uterus, and the reactive stroma of epithelial cancers. Homologues of FAP have been identified in the mouse and Xenopus laevis. FAP is a dual-specificity enzyme that acts as a dipeptidyl peptidase and collagenase in vitro. To explore the role of FAP in vivo, Fap −/− mice were generated by homologous recom

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14

Walter, Christine, Chloé Rafael, Samia Lasaad, Stéphanie Baron, Amel Salhi, and Gilles Crambert. "H,K-ATPase type 2 regulates gestational extracellular compartment expansion and blood pressure in mice." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 318, no. 2 (2020): R320—R328. http://dx.doi.org/10.1152/ajpregu.00067.2019.

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The modifications of the hemodynamic system and hydromineral metabolism are physiological features characterizing a normal gestation. Thus, the ability to expand plasma volume without increasing the level of blood pressure is necessary for the correct perfusion of the placenta. The kidney is essential in this adaptation by reabsorbing avidly sodium and fluid. In this study, we observed that the H,K-ATPase type 2 (HKA2), an ion pump expressed in kidney and colon and already involved in the control of the K+ balance during gestation, is also required for the correct plasma volume expansion and t

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15

Yvonne, Wabai W., Mwonjoria J. K. Maina, and Njagi E. Mwaniki. "Teratogenic potential of Urtica massaica (Mildbr.) and Croton megalocarpus (Hutch) in mice." Journal of Phytopharmacology 7, no. 6 (2018): 460–63. http://dx.doi.org/10.31254/phyto.2018.7601.

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Urtica massaica (Urticaceae) and Croton megalocarpus are used either as vegetables or as food additives and as medicine in traditional African societies. However, in spite of the widespread consumption of these plants as folklore remedies and for diet, there is a scarcity of scientific data on their teratogenicity. Hence this study sought to assess the teratogenic effects of these plant extracts in an animal model. The study was conducted using Swiss albino mice. The extracts of these plants were administered orally in mice which were then euthanized. The weights of the gravid uterus and pups,

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Uchendu, Adaeze, and Enitome Bafor. "Pepper fruit (Dennettia tripetala [annonaceae]) seed inhibits uterine contractions via blockade of intracellular calcium release and extracellular calcium influx in ex vivo studies." Journal of Current Biomedical Research 3, no. 3, May-June (2023): 1031–47. http://dx.doi.org/10.54117/jcbr.v3i3.6.

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Dennettia tripetala (DT) is a tree found in rain forest belt of Nigeria, Cameroon and Ivory Coast. The seed is commonly used in preparing food for mothers after delivery because it is believed to play a role in postpartum uterine contraction. There is however no scientific evidence validating this claim. Hence, the study aimed to investigate the effects of DT seed on non-pregnant and pregnant uterus using mouse model. The dried seeds of DT were macerated in methanol and the effects of DT extract were investigated on uterus tissues isolated from non-pregnant and pregnant mice. DT extract was ex

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Joseph, Gichuru M., Mwonjoria JK Maina, Mburu N. David, and Menza C. Nelson. "Toxicity of Toddalia asiatica is associated with microcephaly and hypochondroplasia in mice." Journal of Phytopharmacology 11, no. 6 (2022): 386–90. http://dx.doi.org/10.31254/phyto.2022.11602.

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In Kenya various plant extracts are widely used as folklore remedies for various ailments including malaria etc. However, use of these traditional remedies poses a risk to the users due to the scarcity of data on their safety including their teratogenic potential. Hence this study evaluated the teratogenic and sub-acute toxic effects of methanol: dichloromethane extract of Toddalia asiatica in animal mice. In the study, young female mice aged between 6-7weeks were mated with mature males and conception confirmed using vaginal plug, maternal weight and breast enlargement. Administration of the

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McCallum, Melissa L., Cindy A. Pru, Andrea R. Smith, et al. "A functional role for AMPK in female fertility and endometrial regeneration." Reproduction 156, no. 6 (2018): 501–13. http://dx.doi.org/10.1530/rep-18-0372.

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Adenosine monophosphate-activated protein kinase (AMPK) is a highly conserved heterotrimeric complex that acts as an intracellular energy sensor. Based on recent observations of AMPK expression in all structures of the female reproductive system, we hypothesized that AMPK is functionally required for maintaining fertility in the female. This hypothesis was tested by conditionally ablating the two catalytic alpha subunits of AMPK, Prkaa1 and Prkaa2, using Pgr-cre mice. After confirming the presence of PRKAA1, PRKAA2 and the active phospho-PRKAA1/2 in the gravid uterus by immunohistochemistry, c

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Mahalik, Michael P., Henry W. Hitner, and Walter C. Prozialeck. "Teratogenic effects and distribution of cadmium (Cd2+) administered via osmotic minipumps to gravid CF-1 mice." Toxicology Letters 76, no. 3 (1995): 195–202. http://dx.doi.org/10.1016/0378-4274(95)80003-v.

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Varian, Bernard J., Katherine T. Weber, Lily J. Kim, et al. "Maternal Microbiota Modulate a Fragile X-like Syndrome in Offspring Mice." Genes 13, no. 8 (2022): 1409. http://dx.doi.org/10.3390/genes13081409.

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Maternal microbial dysbiosis has been implicated in adverse postnatal health conditions in offspring, such as obesity, cancer, and neurological disorders. We observed that the progeny of mice fed a Westernized diet (WD) with low fiber and extra fat exhibited higher frequencies of stereotypy, hyperactivity, cranial features and lower FMRP protein expression, similar to what is typically observed in Fragile X Syndrome (FXS) in humans. We hypothesized that gut dysbiosis and inflammation during pregnancy influenced the prenatal uterine environment, leading to abnormal phenotypes in offspring. We f

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Moreira, C. Q., M. JSS Faria, J. E. Baroneza, R. J. Oliveira, and E. G. Moreira. "Developmental exposure to fenproporex: reproductive and morphological evaluation." Human & Experimental Toxicology 24, no. 8 (2005): 397–402. http://dx.doi.org/10.1191/0960327105ht545oa.

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This study was designed to evaluate the maternal toxicity and teratogenicity of fenproporex, one of the most widelyused anorectic drugs in many countries, including Brazil. Three periods of exposure were evaluated: (a) 30 days before mating; (b) from gestational day (GD) 0 to 14; and (c) 30 days before mating and during pregnancy, until GD 14. Female mice from experimental groups received, by gavage, 15 mg/kg of fenproporex. Treatment with fenproporex increased ambulation of dams in the open field test and did not influence the mobility in the forcedswimming test. There was no significant diff

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Tang, CT, YC Quian, YM Kang, et al. "Study on the ecological distribution of alveolar echinococcus in Hulunbeier pasture of inner Mongolia, China." Parasitology 128 (June 7, 2004): 187–94. https://doi.org/10.1017/S0031182003004438.

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A study on the ecological distribution of alveolar Echinococcus was carried out in the Hulunbeier Pasture of Inner Mongolia, China during 1998 and 1999. Animals examined included wolves (Canis lupus), red foxes (Vulpes vulpes), sand foxes (Vulpes corsac), domestic dogs (Canis familiaris), Microtus brandti, Meriones unguiculatus, Citellus dauricus, Allactaga sibirica, Phodopus sungorus and Ochotona daurica. Three wolves were found to be infected with E. granulosus. Two sand foxes were infected with E. multilocularis. The majority of infections of alveolar echinococcus was found in M. brandti. B

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Zhou, Yiran, Christine Neyt, Nicola J. Batchelor, et al. "Fetal resorption coincides with dysregulated LH secretion in AMH-overexpressing mice." Journal of Endocrinology 253, no. 2 (2022): 53–62. http://dx.doi.org/10.1530/joe-21-0430.

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Female anti-Müllerian hormone (AMH) overexpressing (Thy1.2-AMHTg/0) mice experience fetal resorption (miscarriage) by mid-gestation. This study examined whether the ovary, uterine implantation sites and hypothalamus are potential sites of AMH action, as AMH type-2 receptor (AMHR2) expression is reported in each tissue. Pregnancy in Thy1.2-AMHTg/0 mice was compared to wild-type (WT) mice via histological examination of implantation sites, hormone assays, embryo culture and embryo transfer. Uterine AMH and AMHR2 expression was examined by RT-qPCR and immunohistochemistry. The first signs of feta

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Lambin, Suzan, Rita van Bree,, Ignace Vergote та Johan Verhaeghe. "Chronic Tumor Necrosis Factor-α Infusion in Gravid C57BL6/J Mice Accelerates Adipose Tissue Development in Female Offspring". Journal of the Society for Gynecologic Investigation 13, № 8 (2006): 558–65. http://dx.doi.org/10.1016/j.jsgi.2006.09.001.

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Qureshi, Fariha, and Muhammad Tahir. "Arsenic Induced Vascular Endothelial Dysfunction Prevented by Antioxidants in Fetal kidneys of Albino Mice." Pakistan Postgraduate Medical Journal 31, no. 01 (2021): 18–23. http://dx.doi.org/10.51642/ppmj.v31i01.358.

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Background &Objectives: Cardiovascular diseases and hypertension has a significant correlation with chronic arsenic exposure through drinking water. This study was designed to investigate the prevention of sodium arsenate induced vascular disorders by Vitamins C& E in fetal renal blood vessels of albino mice. Materials & Methods: Gravid albino mice of BALB/c strain (twenty four) were randomly divided into 4 groups having 6 animals each. Control group A was inoculated with 0.1ml/kg/day distilled water I/P for 18 days. Animals of groups B, C & D were given a single I/P inje

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Snyder, SE, B. Peng, JE Pintar, and SR Salton. "Expression of VGF mRNA in developing neuroendocrine and endocrine tissues." Journal of Endocrinology 179, no. 2 (2003): 227–35. http://dx.doi.org/10.1677/joe.0.1790227.

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Analysis of knockout mice suggests that the neurotropin-inducible secreted polypeptide VGF (non-acronymic) plays an important role in the regulation of energy balance. VGF is synthesized by neurons in the central and peripheral nervous systems (CNS, PNS), as well as in the adult pituitary, adrenal medulla, endocrine cells of the stomach and pancreatic beta cells. Thus VGF, like cholecystokinin, leptin, ghrelin and other peptide hormones that have been shown to regulate feeding and energy expenditure, is synthesized in both the gut and the brain. Although detailed developmental studies of VGF l

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Garnier, Vanessa, Wael Traboulsi, Aude Salomon та ін. "PPARγ controls pregnancy outcome through activation of EG-VEGF: new insights into the mechanism of placental development". American Journal of Physiology-Endocrinology and Metabolism 309, № 4 (2015): E357—E369. http://dx.doi.org/10.1152/ajpendo.00093.2015.

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PPARγ-deficient mice die at E9.5 due to placental abnormalities. The mechanism by which this occurs is unknown. We demonstrated that the new endocrine factor EG-VEGF controls the same processes as those described for PPARγ, suggesting potential regulation of EG-VEGF by PPARγ. EG-VEGF exerts its functions via prokineticin receptor 1 (PROKR1) and 2 (PROKR2). This study sought to investigate whether EG-VEGF mediates part of PPARγ effects on placental development. Three approaches were used: 1) in vitro, using human primary isolated cytotrophoblasts and the extravillous trophoblast cell line (HTR-

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Keramidas, M., J. Lavaud, F. Sergent, et al. "Noninvasive and Quantitative Assessment ofIn VivoFetomaternal Interface Angiogenesis Using RGD-Based Fluorescence." BioMed Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/309082.

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Angiogenesis is a key process for proper placental development and for the success of pregnancy. Although numerousin vitromethods have been developed for the assessment of this process, relatively few reliablein vivomethods are available to evaluate this activity throughout gestation. Here we report anin vivotechnique that specifically measures placental neovascularization. The technique is based on the measurement of a fluorescent alphavbeta 3 (αvβ3) integrin-targeting molecule called Angiolone-Alexa-Fluor 700. Theαvβ3integrin is highly expressed by endothelial cells during the neovasculariza

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Wekhe-Emenike, Aruchi,, Adetutu Olubunmi Obulor, Jane Ominini West, and Regina Chike Orlu. "Investigation on the Effect of Sacoglottis gabonensis on Blood Glucose, Body Weight and Behavioural Changes of Mice Exposed to Non-nutritive Sweeteners during Gestation Period." Asian Journal of Research in Zoology 7, no. 4 (2024): 65–70. http://dx.doi.org/10.9734/ajriz/2024/v7i4170.

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Aim: Aim of this research was to investigate the role of Sacoglotts gabonensis on blood sugar, body weight and behavioural changes of mice exposed to artificial sweeteners. Study Design: A total of 16 female mice (mean weight 18.6±2.32g) divided into four groups were used in this study. Methodology: Group A received no sweeteners or S. gabonensis, B received 50mg of sweeteners only, C received 50mg of sweeteners and 250mg/kg/bw of S. gabonensis, D received 250mg/kg/bw of S. gabonensis only for 8weeks. Results: show that group A and D had significant (p<0.05) decrease in blood glucose concen

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OBARO-ONEZEYI, O. E., and P. O. OBARO. "ACUTE TOXICITY AND PREGNANCY ASSESSMENT OF N-HEXANE EXTRACT OF Peperomia pellucida LEAVES (PIPERACEAE) ON FEMALE ALBINO WISTAR RATS." African Journal of Health, Safety and Environment 6, no. 1 (2025): 78–88. https://doi.org/10.52417/ajhse.v6i1.579.

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Peperomia pellucida is used traditionally for the treatment of infertility. Although the effects of the leave extract of P. pellucida on male infertility have been reported, there is no scientific research on female infertility and miscarriages in females in spite of its usefulness in folk medicine. In this research, outcome of the n-hexane extract of Peperomia pellucida leaves was studied on the three (3) stages of pregnancy, delivery and pups delivered. The aim of this study was to investigate the acute toxicity study in mice and determine the effect of the n-hexane extract of Peperomia pell

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Reynaud, Deborah, Roland Abi Nahed, Nicolas Lemaitre, et al. "NLRP7 Promotes Choriocarcinoma Growth and Progression through the Establishment of an Immunosuppressive Microenvironment." Cancers 13, no. 12 (2021): 2999. http://dx.doi.org/10.3390/cancers13122999.

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The inflammatory gene NLRP7 is the major gene responsible for recurrent complete hydatidiform moles (CHM), an abnormal pregnancy that can develop into gestational choriocarcinoma (CC). However, the role of NLRP7 in the development and immune tolerance of CC has not been investigated. Three approaches were employed to define the role of NLRP7 in CC development: (i) a clinical study that analyzed human placenta and sera collected from women with normal pregnancies, CHM or CC; (ii) an in vitro study that investigated the impact of NLRP7 knockdown on tumor growth and organization; and (iii) an in

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Arinola, O. G., S. O. Badmos, and O. G. Ademowo. "Trace Elements and Anti - Oxidant Status in Gravid BALB/c Mice Infected with Plasmodium yoelii Malaria Parasites at Different Gestational Periods." Pakistan Journal of Nutrition 7, no. 6 (2008): 757–62. http://dx.doi.org/10.3923/pjn.2008.757.762.

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Shi, Yijun, Xiuqi Bao, Xiaolin Huo, Zheng Shen, and Tao Song. "50-Hz magnetic field (0.1-mT) altersc-fos mRNA expression of early post implantation mouse embryos and serum estradiol levels of gravid mice." Birth Defects Research Part B: Developmental and Reproductive Toxicology 74, no. 2 (2005): 196–200. http://dx.doi.org/10.1002/bdrb.20036.

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Stoitsova, S. R., L. N. Gorchilova, and J. Daněk. "Effects of three anthelmintics on the tegument ofHymenolepis fraterna(Cestoda)." Parasitology 104, no. 1 (1992): 143–52. http://dx.doi.org/10.1017/s0031182000060881.

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SUMMARYThein vivoeffects of the anthelmintics taenifugin, VÚFB 14170 and VÚFB 15269 on the tegument ofHymenolepis fraternahave been examined by SEM, TEM and cytochemistry. The drugs were given toH. fraterna-infected mice on the 14th day post-infection in a single oral dose of 150, 200 and 200 mg/kg, respectively. By 72 h post-treatment, the drug-induced pathomorphological changes in the tegument indicated that all three drugs had a significant effect. Changes were most pronounced on the brush border and in the intercellular material. On the apical surface, there was blebbing as well as accumul

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Haddad, E. K., A. J. Duclos, and M. G. Baines. "Early embryo loss is associated with local production of nitric oxide by decidual mononuclear cells." Journal of Experimental Medicine 182, no. 4 (1995): 1143–51. http://dx.doi.org/10.1084/jem.182.4.1143.

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In early embryo loss, the fetus may be considered to be an allograft and, therefore, may be rejected by maternal immunocytes. However, the cytotoxic mechanisms involved are still poorly understood. We have previously shown the involvement of natural killer (NK) cells and mononuclear cells expressing Mac-1 (CD11b) and F4/80 in resorbing compared to nonresorbing embryos. In this study, the role of nitric oxide (NO) in the mechanism of early embryo loss was studied. Pregnant CBA/J females mated with DBA/2 males (20-30% early embryo loss) and CD1 females mated with CD1 males (5-10% early embryo lo

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Spooner, Madelyn K., Yasser Y. Lenis, Rachel Watson, Daniela Jaimes, and Amanda L. Patterson. "The role of stem cells in uterine involution." Reproduction 161, no. 3 (2021): R61—R77. http://dx.doi.org/10.1530/rep-20-0425.

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Uterine remodeling during pregnancy and repair postpartum are fundamental to the successful propagation of eutherian species. The most drastic remodeling occurs in species with invasively implanting embryos, including humans and mice. During embryo implantation, embryonic trophoblasts breach the epithelium, penetrating into the stroma. Stromal cell decidualization, which is critical for the establishment and maintenance of early pregnancy, occurs throughout the implantation site. Trophoblasts further invade into and remodel uterine spiral arteries, which is necessary for placental formation. T

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Shymanovich, Tatsiana, Nima Hajhashemi, and Gideon Wasserberg. "Quantitative and Qualitative Costs of Autogeny in Phlebotomus papatasi (Diptera: Psychodidae) Sand Flies." Journal of Medical Entomology 57, no. 3 (2019): 852–61. http://dx.doi.org/10.1093/jme/tjz223.

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Abstract Most sand flies and mosquitoes require a bloodmeal for egg production, but when blood-sources are scarce, some of them can reproduce without it, so called facultative autogeny. The evolution of autogenous reproduction is thought to involve a trade-off between the benefit of reproducing in the absence of bloodmeal hosts versus the quantitative cost of reduced fecundity and/or or qualitative effect on reduced offspring development and survivorship. We blood-fed (BF) some Phlebotomous papatasi (Scopoli) sand fly females on mice while keeping others (from the same cohort) not BF. We then

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Sutton, Jessica A., Lisa M. Rogers, Ryan Steven Doster, Jennifer Angeline Gaddy, and David M. Aronoff. "Group B Streptococcus infection induces M1-like activation in human placental and mouse decidual macrophages." Journal of Immunology 198, no. 1_Supplement (2017): 208.9. http://dx.doi.org/10.4049/jimmunol.198.supp.208.9.

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Abstract Group B Streptococcus (GBS), a vaginal colonizing gram-positive bacterium, is a leading cause of neonatal death and sepsis. How GBS evades macrophage defenses in the gravid uterus is not yet known. In response to stimuli, macrophages are activated along a spectrum known as polarization ranging from classically-activated, pro-inflammatory “M1” to alternatively-activated anti-inflammatory “M2” macrophages. These activation states can contribute to disease pathogenesis. This study aims to define changes in macrophage activation in response to GBS infection. Human monocyte derived macroph

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Fan, Qiying, Xing Yin, Abeer Rababa’h, et al. "Absence of gravin-mediated signaling inhibits development of high-fat diet-induced hyperlipidemia and atherosclerosis." American Journal of Physiology-Heart and Circulatory Physiology 317, no. 4 (2019): H793—H810. http://dx.doi.org/10.1152/ajpheart.00215.2019.

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Gravin, an A-kinase anchoring protein, is known to play a role in regulating key processes that lead to inflammation and atherosclerosis development, namely, cell migration, proliferation, and apoptosis. We investigated the role of gravin in the development of high-fat diet (HFD)-induced atherosclerosis and hyperlipidemia. Five-week-old male wild-type (WT) and gravin-t/t mice were fed a normal diet or an HFD for 16 wk. Gravin-t/t mice showed significantly lower liver-to-body-weight ratio, cholesterol, triglyceride, and very low-density lipoprotein levels in serum as compared with WT mice on HF

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Clifton, Lauryn, Amber Petty, Morgan Burns, and Amy T. Desaulniers. "177 Early Weaning Impairs Reproductive Development and Fertility of the Male." Journal of Animal Science 100, Supplement_2 (2022): 86. http://dx.doi.org/10.1093/jas/skac064.139.

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Abstract Reproductive failure remains a major limitation to the efficiency of livestock production. Early weaning has been linked with reduced male fertility; however, the biological mechanisms mediating this effect are largely undefined. The objective of this study was to develop a murine model to examine the effects of early weaning on testis development and function. Neonatal CD-1 mice were reared with their dams and littermates; pups were randomly assigned to either conventional (21 d; n = 12) or early (18 d; n = 12) weaning. At maturity, males were paired with a primiparous, non-littermat

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Zhang, Qi, Shuang Xie, Qiu Zhong, Xinyue Zhang, Liufang Luo, and Qian Yang. "Bacillus subtilis-Derived Surfactin Alleviates Offspring Intestinal Inflammatory Injuries Through Breast Milk." Nutrients 17, no. 6 (2025): 1009. https://doi.org/10.3390/nu17061009.

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Background: Enteric and diarrheal diseases pose a significant threat to infant health, highlighting the importance of immune defenses in early life, especially maternal protection, in establishing a robust gastrointestinal environment. Surfactin, a bioactive peptide from Bacillus subtilis, has immunomodulatory properties, yet its influence on offspring via maternal gut interference is not fully understood. This study examines the effects of maternal surfactin consumption on breast milk’s immunological properties and its consequent effects on neonatal intestinal health. Methods: Twenty-eight gr

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Sheng, JianRong, and Betty Soliven. "IL-10 is critical in the regulatory function of CD1dhiCD5+ B cells in Experimental Autoimmune Myasthenia Gravis (THER2P.964)." Journal of Immunology 194, no. 1_Supplement (2015): 67.15. http://dx.doi.org/10.4049/jimmunol.194.supp.67.15.

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Abstract Autoimmune Myasthenia Gravis (MG) is a T cell-dependent, B cell-mediated autoimmune disorder in which autoantibodies is produced targeting the skeletal muscle acetylcholine receptor (AChR). IL-10-competent subset within CD1dhiCD5+ B cells, also known as B10 cells, has been shown to regulate autoimmune diseases. In our previous study, adoptive transfer of CD1dhiCD5+ B cells expanded in vivo by GM-CSF prevented and suppressed Experimental Autoimmune Myasthenia Gravis (EAMG), which was associated with downregulation of mature dendritic cell marker and expansion of regulatory T cell resul

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Brown, Paul M., та Katherine A. Wall. "Role of IFN-γ in passive experimental autoimmune myasthenia gravis (99.4)". Journal of Immunology 182, № 1_Supplement (2009): 99.4. http://dx.doi.org/10.4049/jimmunol.182.supp.99.4.

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Abstract In myasthenia gravis, anti-acetylcholine receptor (AChR) antibody is thought to cause damage through the activation of complement, via the classical complement pathway, in addition to causing internalization of AChRs. Previous research has shown that interleukin 12 (IL-12), the major inducer of IFN-γ production in the immune system, enhances clinical experimental myasthenia gravis (EAMG) in C57BL/6 (B6) mice. We performed passive transfer experiments with mAb399, a mouse anti-AChR monoclonal antibody recognizing the immunodominant mouse AChR epitope, using both B6 and IFN-γ-/- mice. T

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Zhang, Guang-Xian, Bao-Guo Xiao, Xue-Feng Bai, Peter H. van der Meide, Anders Örn та Hans Link. "Mice with IFN-γ Receptor Deficiency Are Less Susceptible to Experimental Autoimmune Myasthenia Gravis". Journal of Immunology 162, № 7 (1999): 3775–81. http://dx.doi.org/10.4049/jimmunol.162.7.3775.

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Abstract IFN-γ can either adversely or beneficially affect certain experimental autoimmune diseases. To study the role of IFN-γ in the autoantibody-mediated experimental autoimmune myasthenia gravis (EAMG), an animal model of myasthenia gravis in humans, IFN-γR-deficient (IFN-γR−/−) mutant C57BL/6 mice and congenic wild-type mice were immunized with Torpedo acetylcholine receptor (AChR) plus CFA. IFN-γR−/− mice exhibited significantly lower incidence and severity of muscle weakness, lower anti-AChR IgG Ab levels, and lower Ab affinity to AChR compared with wild-type mice. Passive transfer of s

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Zeng, Yuanfeng, Haihua Zeng, Xinghua Liu, and Tingting Fan. "Buzhong Yiqi decoction attenuates acquired myasthenia by regulating the JAK2/STAT3/AKT signaling pathway, inhibiting inflammation, and improving mitochondrial function." Allergologia et Immunopathologia 52, no. 5 (2024): 59–64. http://dx.doi.org/10.15586/aei.v52i5.1147.

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Acquired myasthenia (AM), a debilitating autoimmune disease, is typically characterized by skeletal muscle fatigue and weakness. Despite advances in myasthenia gravis treatment, current approaches remain unsatisfactory and many result in unexpected side effects. Traditional Chinese medicine has shown great potential in the treatment of myasthenia gravis, including relieving myasthenic symptoms, improving patients' quality of life, and reducing Western medicine side effects. This study investigates the protective effects and mechanism of BZYQD in mice with acquired myasthenia. BZYQD alleviates

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Raju, Raghavan, Wen-Zhi Zhan, Peter Karachunski, Bianca Conti-Fine, Gary C. Sieck, and Chella David. "Polymorphism at the HLA-DQ Locus Determines Susceptibility to Experimental Autoimmune Myasthenia Gravis." Journal of Immunology 160, no. 9 (1998): 4169–74. http://dx.doi.org/10.4049/jimmunol.160.9.4169.

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Abstract Studies in myasthenia gravis (MG) patients demonstrate that polymorphism at the HLA-DQ locus influences the development of MG. Several studies using the mouse models also demonstrate the influence of class II molecules, especially the H2-A, which is the mouse homologue of HLA-DQ, in experimental autoimmune myasthenia gravis (EAMG). We used transgenic mice expressing two different DQ molecules, DQ8 (DQA1*0301/B1*0302) and DQ6 (DQA1*0103/B1*0601), to evaluate the role of HLA-DQ genes in MG. These mice do not express endogenous mouse class II molecules since they contain the mutant H2-Aβ

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Shi, Fu-Dong, Hulun Li, Huabing Wang, et al. "Mechanisms of Nasal Tolerance Induction in Experimental Autoimmune Myasthenia Gravis: Identification of Regulatory Cells." Journal of Immunology 162, no. 10 (1999): 5757–63. http://dx.doi.org/10.4049/jimmunol.162.10.5757.

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Abstract Autoantigen administration via nasal mucosal tissue can induce systemic tolerance more effectively than oral administration in a number of experimental autoimmune diseases, including Ab-mediated experimental autoimmune myasthenia gravis, a murine model of myasthenia gravis. The mechanisms underlying nasal tolerance induction are not clear. In this study, we show that nasal administration of acetylcholine receptor (AChR) in C57BL/6 mice, before immunizations with AChR in adjuvant, results in delayed onset and reduced muscle weakness compared with control mice. The delayed onset and red

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Christadoss, P., J. M. Lindstrom, N. Talal, C. R. Duvic, A. Kalantri, and M. Shenoy. "Immune response gene control of lymphocyte proliferation induced by acetylcholine receptor-specific helper factor derived from lymphocytes of myasthenic mice." Journal of Immunology 137, no. 6 (1986): 1845–49. http://dx.doi.org/10.4049/jimmunol.137.6.1845.

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Abstract The role of lymphokines secreted by acetylcholine receptor (AChR)-reactive lymphocytes in the regulation of an autoimmune response to AChR has not been studied in the human or murine model of myasthenia gravis. We investigated whether AChR-immune lymphocytes derived from mice with experimental autoimmune myasthenia gravis (EAMG) can produce an AChR-specific, genetically controlled soluble factor with biologic activity. AChR-reactive lymphocytes of mice with EAMG secreted an AChR-specific helper factor in vitro, which induced proliferation of AChR-immune but not Mycobacterium tuberculo

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Infante, A. J., P. A. Thompson, K. A. Krolick, and K. A. Wall. "Determinant selection in murine experimental autoimmune myasthenia gravis. Effect of the bm12 mutation on T cell recognition of acetylcholine receptor epitopes." Journal of Immunology 146, no. 9 (1991): 2977–82. http://dx.doi.org/10.4049/jimmunol.146.9.2977.

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Abstract C57BL/6 (B6) mice respond to immunization with acetylcholine receptor (AChR) from Torpedo californica as measured by T cell proliferation, antibody production, and the development of muscle weakness resembling human myasthenia gravis. The congenic strain B6.C-H-2bm12 (bm12), which differs from B6 by three amino acid substitutions in the beta-chain of the MHC class II molecule I-A, develops a T cell proliferative response but does not produce antibody or develop muscle weakness. By examining the fine specificity of the B6 and bm12 T cell responses to AChR by using T cell clones and syn

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Balasa, Balaji, Caishu Deng, Jae Lee та ін. "Interferon γ (IFN-γ) Is Necessary for the Genesis of Acetylcholine Receptor–induced Clinical Experimental Autoimmune Myasthenia gravis in Mice". Journal of Experimental Medicine 186, № 3 (1997): 385–91. http://dx.doi.org/10.1084/jem.186.3.385.

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Experimental autoimmune myasthenia gravis (EAMG) is an animal model of human myasthenia gravis (MG). In mice, EAMG is induced by immunization with Torpedo californica acetylcholine receptor (AChR) in complete Freund's adjuvant (CFA). However, the role of cytokines in the pathogenesis of EAMG is not clear. Because EAMG is an antibody-mediated disease, it is of the prevailing notion that Th2 but not Th1 cytokines play a role in the pathogenesis of this disease. To test the hypothesis that the Th1 cytokine, interferon (IFN)-γ, plays a role in the development of EAMG, we immunized IFN-γ knockout (

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